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Importance Geographic atrophy (GA) secondary to age-related macular degeneration is a leading cause of visual disability in older individuals. A phase 2 trial suggested that lampalizumab, a selective complement factor D inhibitor, reduced the rate of GA enlargement, warranting phase 3 trials. Objective To assess the safety and efficacy of lampalizumab vs sham procedure on enlargement of GA. Design, Setting, and Participants Two identically designed phase 3 double-masked, randomized, sham-controlled clinical trials, Chroma and Spectri, enrolled participants from August 28, 2014, to October 6, 2016, at 275 sites in 23 countries. Participants were aged 50 years or older, with bilateral GA and no prior or active choroidal neovascularization in either eye and GA lesions in the study eye measuring 2.54 to 17.78 mm 2 with diffuse or banded fundus autofluorescence patterns. Interventions Participants were randomized 2:1:2:1 to receive 10 mg of intravitreous lampalizumab every 4 weeks, sham procedure every 4 weeks, 10 mg of lampalizumab every 6 weeks, or sham procedure every 6 weeks, through 96 weeks. Main Outcomes and Measures Safety and efficacy assessed as mean change from baseline in GA lesion area at week 48 from centrally read fundus autofluorescence images of the lampalizumab arms vs pooled sham arms, in the intent-to-treat population and by complement factor I–profile genetic biomarker. Results A total of 906 participants (553 women and 353 men; mean [SD] age, 78.1 [8.1] years) were enrolled in Chroma and 975 participants (578 women and 397 men; mean [SD] age, 77.9 [8.1] years) were enrolled in Spectri; 1733 of the 1881 participants (92.1%) completed the studies through 48 weeks. The adjusted mean increases in GA lesion area from baseline at week 48 were 1.93 to 2.09 mm 2 across all groups in both studies. Differences in adjusted mean change in GA lesion area (lampalizumab minus sham) were −0.02 mm 2 (95% CI, −0.21 to 0.16 mm 2 ; P = .80) for lampalizumab every 4 weeks in Chroma, 0.16 mm 2 (95% CI, 0.00-0.31 mm 2 ; P = .048) for lampalizumab every 4 weeks in Spectri, 0.05 mm 2 (95% CI, −0.13 to 0.24 mm 2 ; P = .59) for lampalizumab every 6 weeks in Chroma, and 0.09 mm 2 (95% CI, −0.07 to 0.24 mm 2 ; P = .27) for lampalizumab every 6 weeks in Spectri. No benefit of lampalizumab was observed across prespecified subgroups, including by complement factor I–profile biomarker. Endophthalmitis occurred after 5 of 12 447 injections (0.04%) or in 5 of 1252 treated participants (0.4%) through week 48. Conclusions and Relevance In Chroma and Spectri, the largest studies of GA conducted to date, lampalizumab did not reduce GA enlargement vs sham during 48 weeks of treatment. Results highlight the substantial and consistent enlargement of GA, at a mean of approximately 2 mm 2 per year. Trial Registration ClinicalTrials.gov Identifier:NCT02247479andNCT02247531

Dexamethasone intravitreal implant 0.7 mg (DEX 0.7) was approved for treatment of diabetic macular edema (DME) after demonstration of its efficacy and safety in the MEAD registration trials. We performed subgroup analysis of MEAD study results to evaluate the efficacy and safety of DEX 0.7 treatment in patients with previously treated DME. Three-year, randomized, sham-controlled phase 3 study in patients with DME, best-corrected visual acuity (BCVA) of 34–68 Early Treatment Diabetic Retinopathy Study letters (20/200–20/50 Snellen equivalent), and central retinal thickness (CRT) ≥300 μm measured by time-domain optical coherence tomography. Patients were randomized to 1 of 2 doses of DEX (0.7 mg or 0.35 mg), or to sham procedure, with retreatment no more than every 6 months. The primary endpoint was ≥15-letter gain in BCVA at study end. Average change in BCVA and CRT from baseline during the study (area-under-the-curve approach) and adverse events were also evaluated. The present subgroup analysis evaluated outcomes in patients randomized to DEX 0.7 (marketed dose) or sham based on prior treatment for DME at study entry. Baseline characteristics of previously treated DEX 0.7 (n = 247) and sham (n = 261) patients were similar. In the previously treated subgroup, mean number of treatments over 3 years was 4.1 for DEX 0.7 and 3.2 for sham, 21.5 % of DEX 0.7 patients versus 11.1 % of sham had ≥15-letter BCVA gain from baseline at study end (P = 0.002), mean average BCVA change from baseline was +3.2 letters with DEX 0.7 versus +1.5 letters with sham (P = 0.024), and mean average CRT change from baseline was −126.1 μm with DEX 0.7 versus −39.0 μm with sham (P

Background Preclinical testing of potential therapies for Duchenne muscular dystrophy (DMD) is conducted predominantly of the mdx mouse. But lack of a detailed quantitative description of the pathology of this animal limits our ability to evaluate the effectiveness of putative therapies or their relevance to DMD. Methods Accordingly, we have measured the main cellular components of muscle growth and regeneration over the period of postnatal growth and early pathology in mdx and wild-type (WT) mice; phalloidin binding is used as a measure of fibre size, myonuclear counts and BrdU labelling as records of myogenic activity. Results We confirm a two-phase postnatal growth pattern in WT muscle: first, increase in myonuclear number over weeks 1 to 3, then expansion of myonuclear domain. Mdx muscle growth lags behind that of WT prior to overt signs of pathology. Fibres are smaller, with fewer myonuclei and smaller myonuclear domains. Moreover, satellite cells are more readily detached from mdx than WT muscle fibres. At 3 weeks, mdx muscles enter a phase of florid myonecrosis, accompanied by concurrent regeneration of an intensity that results in complete replacement of pre-existing muscle over the succeeding 3 to 4 weeks. Both WT and mdx muscles attain maximum size by 12 to 14 weeks, mdx muscle fibres being up to 50% larger than those of WT as they become increasingly branched. Mdx muscle fibres also become hypernucleated, containing twice as many myonuclei per sarcoplasmic volume, as those of WT, the excess corresponding to the number of centrally placed myonuclei. Conclusions The best-known consequence of lack of dystrophin that is common to DMD and the mdx mouse is the conspicuous necrosis and regeneration of muscle fibres. We present protocols for measuring this in terms both of loss of muscle nuclei previously labelled with BrdU and of the intensity of myonuclear labelling with BrdU administered during the regeneration period. Both measurements can be used to assess the efficacy of putative antinecrotic agents. We also show that lack of dystrophin is associated with a number of previously unsuspected abnormalities of muscle fibre structure and function that do not appear to be directly associated with myonecrosis.

Aims Oral glucose-lowering medications are associated with excess risk of heart failure (HF). Given the absence of comparative data among drug classes, we performed a retrospective study in 32 Health Services of 16 Italian regions accounting for a population of 18 million individuals, to assess the association between HF risk and use of sulphonylureas, DPP-4i, and glitazones. Methods and results We extracted data on patients with type 2 diabetes who initiated treatment with DPP-4i, thiazolidinediones, or sulphonylureas alone or in combination with metformin during an accrual time of 2 years. The endpoint was hospitalization for HF (HHF) occurring after the first 6 months of therapy, and the observation was extended for up to 4 years. A total of 127 555 patients were included, of whom 14.3% were on DPP-4i, 72.5% on sulphonylurea, 13.2% on thiazolidinediones, with average 70.7% being on metformin as combination therapy. Patients in the three groups differed significantly for baseline characteristics: age, sex, Charlson index, concurrent medications, and previous cardiovascular events. During an average 2.6-year follow-up, after adjusting for measured confounders, use of DPP-4i was associated with a reduced risk of HHF compared with sulphonylureas [hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.62–0.97; P = 0.026]. After propensity matching, the analysis was restricted to 39 465 patients, and the use of DPP-4i was still associated with a lower risk of HHF (HR 0.70; 95% CI 0.52–0.94; P = 0.018). Conclusion In a very large observational study, the use of DPP-4i was associated with a reduced risk of HHF when compared with sulphonylureas.

Atypical hemolytic uremic syndrome (aHUS), is mainly present in children, who have high risks of end-stage kidney disease (ESKD), post-transplant recurrence and death. aHUS is linked to defective regulation of the complement alternative pathway (AP), with a prominent cause being mutation/inhibition of the negative regulator complement factor H (CFH). CFH function can be restored via infusion of fresh frozen plasma (FFP), a treatment that was effective for several years in a patient heterozygous for a cfh mutation, before the patient progressed to ESKD. While on dialysis, FFP was replaced with eculizumab, which blocks C5 cleavage and thus halts progression of the terminal complement pathway. Patient plasma samples collected during FFP and eculizumab treatment phases were assessed for AP activity (via erythrocyte lysis assays) and for overall complement activity (via ELISA-based screen). Assay results indicated that FFP partially restored AP regulation, an observation supported by in vitro modeling of FFP treatment using purified CFH, while eculizumab completely blocked complement activity. The same approach was used to model in vitro a potential aHUS treatment approach based on blocking the AP effector properdin (complement factor P; CFP) with an anti-properdin antibody. These results provide insights into the efficacy of aHUS treatment and highlight the usefulness of in vitro assays in monitoring and predicting therapeutic responses and testing new treatment possibilities.

Objective To assess the overall effectiveness of anti-vascular endothelial growth factor (VEGF) therapy in treatment-naïve patients with neovascular age-related macular degeneration (nAMD) in a clinical practice setting. Study design EAGLE was a retrospective, 2-year, cohort observational, multicenter study conducted in Italy that analyzed secondary data of treatment-naïve patients with nAMD. The primary endpoint evaluated the mean annualized number of anti-VEGF injections at Years 1 and 2. The main secondary endpoints analyzed the mean change in visual acuity (VA) from baseline and variables associated with visual outcomes at Years 1 and 2. Results Of the 752 patients enrolled, 745 (99.07%) received the first dose of anti-VEGF in 2016. Overall, 429 (57.05%) and 335 (44.5%) patients completed the 1- and 2-year follow-ups, respectively. At baseline, mean (standard deviation, SD) age was 75.6 (8.8) years and the mean (SD) VA was 53.43 (22.8) letters. The mean (SD) number of injections performed over the 2 years was 8.2 (4.1) resulting in a mean (SD) change in VA of 2.45 (19.36) (P = 0.0005) letters at Year 1 and −1.34 (20.85) (P = 0.3984) letters at Year 2. Linear regression models showed that age, baseline VA, number of injections, and early fluid resolution were the variables independently associated with visual outcomes at Years 1 and 2. Conclusions The EAGLE study analyzed the routine clinical practice management of patients with nAMD in Italy. The study suggested that visual outcomes in clinical practice may be improved with earlier diagnosis, higher number of injections, and accurate fluid resolution targeting during treatment induction.

The decarbonizing process of the transportation system and the spread of unplanned renewables energy source, such as photovoltaic and wind energies, brought the constant need of ever more efficient energy storage technologies. Among these technologies, batteries, particularly the li-ion chemistry, are widely used in automotive and energy storage applications. For an optimized management of the cell it is advisable to have models that can accurately describe cell behaviour. In this paper a battery model for performance simulation in automotive application is identified. The main shapes of battery cells with their own advantages and disadvantages are shown, and a roundup of the best available 18650 cells is given. Finally, a test-bench for the parameter estimation of the cells is implemented.

Partial discharge (PD) activity in the insulation system of an electrical equipment can determine the failure of the whole apparatus. PD sensors are widely used in high-voltage electrical systems as the main elements of a detecting system oriented to real time monitoring. Recently, non-invasive sensors have been proposed in industrial applications for cable and other sensitive electrical parts: they are based both on capacitive and on the electromagnetic radiating coupling. In order to assess the real performance of a new sensor produced by a high voltage AC cables manufacturer, the paper proposes electromagnetic fullwave simulation results.

This chapter focuses on the evaluation of the performances of different antenna sensors suitable for Partial Discharge (PD) measurements. Monopole, triangular and spherical antennas were simulated by means of the surface method of moments. The transmitting system is modeled by a power electronic device with a fault current between two metal plates. The shape of the simulated, transmitted and received signals, has been compared to verify the sensor that provides the best fidelity among the three. The auto-correlation function and the Pearson correlation index are adopted here for the comparison. A discussion on the dynamic characteristic of the different antenna probes and their use in different application is proposed.

This work analyses the state of water resources in six Mediterranean islands: Corsica, Crete, Cyprus, Mallorca, Malta and Sicily. The analysis is focused on the prevailing social, economic and hydroclimatological characteristics of these islands in order to identify the main common features affecting water availability, demand and use. A detailed analysis of the state of water resources in all the considered islands has been carried out. A background of current conditions relating to freshwater availability, quality and use has been established. Different strategies to face water scarcity and enhance water quality in theislands have been assessed in a context of climate change which is a common threat. The identification of similar problems for all the islands highlights the importance of strengthening inter-islands co-operation in the field of sustainable water resources management. © 2014, Pleiades Publishing, Ltd.

Background/objectives: To compare the number of eye surgical procedures performed in Italy in the 2 months following the beginning of lockdown (study period) because of COVID-19 epidemic with those performed in the two earlier months of the same year (intra-year control) and in the period of 2019 corresponding to the lockdown (inter-year control). Methods: Retrospective analysis of surgical procedures carried out at 39 Academic hospitals. A distinction was made between elective and urgent procedures. Intravitreal injections were also considered. Percentages for all surgical procedures and incidence rate ratios (IRR) for rhegmatogenous retinal detachment (RRD) events were calculated. A p value Results: A total of 20,886 versus 55,259 and 56,640 patients underwent surgery during the lockdown versus intra-and inter-year control periods, respectively. During the lockdown, only 70% of patients for whom an operation/intravitreal injection was recommended, finally underwent surgery; the remaining patients did not attend because afraid of getting infected at the hospital (23%), taking public transportation (6.5%), or unavailable swabs (0.5%). Elective surgeries were reduced by 96.2% and 96.4%, urgent surgeries by 49.7% and 50.2%, and intravitreal injections by 48.5% and 48.6% in the lockdown period in comparison to intra-year and inter-year control periods, respectively. IRRs for RRDs during lockdown dropped significantly in comparison with intra- and inter-year control periods (CI: 0.65–0.80 and 0.61–0.75, respectively, p Conclusion: This study provides a quantitative analysis of the reduction of eye surgical procedures performed in Italy because of the COVID-19 epidemic.

BackgroundTo evaluate the safety and tolerability of ranibizumab 0.5 mg in patients with uni/bilateral neovascular age-related macular degeneration (nAMD) and best-corrected visual acuity (BCVA)MethodsIn this 12-month, prospective, multicentre, open-label, single arm, pragmatic interventional study, patients (N=941) aged ≥ 50 years were to receive ranibizumab as per approved label, monthly until maximum stable visual acuity (VA) was achieved (initially, three or more injections may be required). Thereafter, patients were to be monitored monthly for VA and treatment was to be resumed if VA was reduced due to disease activity.ResultsOf the 936 patients treated with ranibizumab at least once during the study, 823/113 were unilaterally/bilaterally (not simultaneously) treated . The mean (SD) number of ranibizumab injections during the study was 5.4 (2.9)/10.6 (5.0) injections in uni/bilaterally treated patients. Three systemic drug-related adverse events (AEs) (all serious, all in unilaterally treated patients) and 18 systemic AE of special interest (AESIs) (11 serious, 16/2 in unilaterally/bilaterally treated patients) occurred during the study. The annual incidence rate (AIR) (events/1000 person-years) for systemic drug-related AEs, considering a 15-day/30-day risk period, 11.0/8.5 for unilaterally treated patients. Considering the same risk period, the AIR (events/1000 person-years) for systemic AESIs for unilaterally treated patients was 22.1/19.9. Considering a 30-day risk period, the AIR (events/1000 treated eye-years) of ocular drug-related AEs was 23 and AESIs was 11.5.ConclusionsThe low incidence of AEs and AESIs demonstrated the good safety and tolerability of ranibizumab in unilaterally/bilaterally treated patients with nAMD in this real-world setting.

The high diffusion of electric vehicles is evidenced by every sector magazine or by the catalog of all the manufacturers inserting incessantly new models. But what are the user's most hidden reactions to the new world of vehicles? Is the user ready for the fifth level of automation (fully automatic driving and absence of the driving position)? The purpose of this paper is to present and discuss the psychological aspects that influence the adoption of electric vehicles by users and beyond. Topics such as the egg and chicken paradox (electric vehicles and charging stations, who was born first) but also performance anxiety (range anxiety) will be addressed. Contradictions and irony will characterize this paper.

The popularity of electric vehicles is evidenced by the broad range of manufacturers presenting new models of plug-in hybrid and battery vehicles. However, the success of the revolution or, rather, the rebirth of electric vehicles, is hanging by a thread, as it lacks the involvement of a large number of users, and many psychological mechanisms hinder it. What are users’ true feelings about this new world of vehicles? Are people ready for the fifth level of automation, i.e., fully automatic driving and the absence of the driving position? The purpose of this paper is to present and discuss the psychological aspects that influence the adoption of electric vehicles. Topics such as the chicken and egg paradox (electric vehicles and charging stations) and performance anxiety (regarding, e.g., range) are addressed. This review is characterized by contradictions and irony.

In Portugal, the transition to new forms of mobility has begun in recent years, but there are still obstacles to overcome. Currently, hybrid vehicles (PHEVs) are the most widespread and accepted by the community and that is probably due to range anxiety, having in fact the possibility of double charging (both through the thermal engine and the electric battery). Furthermore, it must be considered that in addition to electric vehicles, another valid alternative to mobility in the near future is the hydrogen vehicles one. These appear to be even more sustainable from the point of view of air emissions, but on the other hand the costs for the production of hydrogen are still too high. Then, the aim of this study, is to understand if the use of Fuel Cell can find place in Portugal and which cities are most ready to implement this technology. After an analysis of the actual e-mobility scenario in Portugal and based on the history of EV data of the last years, this paper predicts the cities in which a hydrogen refuelling infrastructure should expected to be more profitable, presenting the probable market trend of the same.

The energy storage is one of the most discussed topics among Electrical Vehicles (EVs) research. Currently, supercapacitors (SCs) are collecting even more attention due to their unique features such as high-power density, high life cycle and lack of maintenance. In this paper, a supercapacitor model suitable for the simulation in automotive applications is identified. The model parameters are estimated and used to simulate the behaviour of a commercial SCs bank in different operating conditions. The model is finally validated considering experimental results.

The expansion of electric vehicles in Italy, has already started a few years ago, but some aspects prevent its expansion. Currently users prefer hybrid technology, mainly due to socio-economic factors related to initial investment and anxiety about autonomy. The aim of the document is to understand if the adoption of Fuel Cell technology can be a solution to overcome the problems of environmental pollution. The possibility to be able to use fuel cells to store electricity is very advantageous, especially on charging times that are significantly reduced. Based on the current situation and analyzing the available data, this work reports the current state of electric mobility in Italy and tries to provide forecasts to understand in which cities the Fuel Cell charging infrastructure should be more favorable.

Our existence is immersed in a solution of energy, which is often left to degrade because we perceive this energy as expendable [...]

In modern HV apparatuses the wide use of electronic converters, increase the stress on the involved insulation systems and thus affect the reliability of the whole power grid. Additionally, such non-sinusoidal voltage shapes contain high gradient flanks that create problems in the detection of partial discharge (PD) activity. The aim of this paper is to discuss the methodology on how to suitably approach PD detection in insulation systems exposed to various voltage waveshapes in general by comparing two different measuring systems. The first one, equipped with a resonant PD decoupler, designed specifically for detection at typical power electronic waveshapes and the other one, based on an antenna sensor with flat frequency response, a general-purpose AC system. It was found that not so much the acquisition principles as the features are important for effective detection of PD signals appearing at rapidly changing test voltages from power electronic devices.

This paper presents the performances of rainfall energy harvesting through the use of a piezoelectric transducer and an Arduino-based measuring system. Different studies agree on the possibility of generating electricity from rainfall, but to date, a study on measuring the quantity of energy produced during rainfall is still missing. The present study begins with results obtained from laboratory researchers using piezoelectric transducers and oscilloscopes, finalized to measure the energy produced from a single raindrop, and concludes with an ad hoc Arduino-based measuring system, aimed to measure the actual amount of electrical energy produced by a piezoelectric transducer that is exposed to rainfall of variable durations.

The paper provides the results of a detailed experimental study on the variations of the characteristics of an interior permanent magnet synchronous motor, when load, speed and/or magnetization conditions vary. In particular, the characterization is carried out by assessing, for several working conditions, the motor parameters that influence its efficiency. From the knowledge of the variability of these parameters, it is possible to develop a dynamic model of the motor, which accurately describes its behaviour and allows estimating the power losses for whatever speed and load. In order to validate the model, the values of the power losses obtained by using the model are compared with the values measured with experimental tests. The study shows that it is possible to maximize the motor efficiency just acting on the direct axis current component and, therefore, it can be considered a first step towards the definition of a loss model algorithm for a control drive system able to minimize in real-time the power losses of the motor.

The aim of this work is the characterization of a dynamic wireless charging system low power prototype and the validation of a simplified mathematical model of the employed double D coils. The difference between a single receiver and a dual receiver system is also shown, highlighting how the last one can significantly reduce the costs of the charging infrastructure.

In the last decade, the issue of air pollution or the reduction of CO2 emissions has become of extreme interest both for civil society and then for the industrial and scientific research world. For this reason, the scientific research on automotive is called to answer with increasingly innovative solutions. One of the principal subjects are the storage and the utilization of the electric energy for electrical and hybrid vehicles. Nowadays, supercapacitors are getting more and more attention because of their characteristics that allow them to be a bridge between electrolytic capacitors and batteries in several application such as bust-mode energy delivery, regenerative breaks and so on. The aim of this work is the modelling, simulation and characterization of a supercapacitor for the seen automotive applications.

In the last decade, remarkable developments have concerned the methods of space charge measurement in the field of insulation systems diagnostic. In particular, methods based on acoustic and thermal phenomena have been largely used. The present review provides a broad overview on the different techniques used describing, for each of them, the working principle, the main features and the most relevant applications. Further details are provided for the Pulsed Electro-Acoustic (PEA) method, as it seems to be the most used. This article provides more details on its historical evolution, showing evidence for its technological limits and taking into consideration the advantages and drawn from the different configurations of the measuring cell. A similar approach has been used for the group of thermal methods, whereas for the optical methods only the basic working principle and latest applications are reported.

Hybrid Energy Storage Systems (HESS) have been very popular in recent years in different applications, from electric vehicles (EVs) to smart grids and renewable energies, due to the growing need to accumulate electricity. The concept of hybridization arises from the requirement of both high energy and specific power. The battery/supercapacitor (SC) system offers great advantages in a DC bus, giving the opportunity to provide high amounts of power to the loads. In this paper, a system composed of two bidirectional DC-DC converters, one connected to a battery pack and one to a stack of supercapacitors, is presented for a DC bus in electrical mobility (E-Mobility) applications. The proposed control technique is based on the concept of power sharing, so that the high-power spikes are mainly provided by supercapacitors, while the battery is responsible for providing the average power and recharging the supercapacitors when necessary.

The power quality requirements are increasingly stringent, due to the continuous growth of devices connected to the grid that introduce harmonics. These devices include DC to AC energy conversion systems, i.e. grid connected inverters. The design, control and operation of these systems must take into account the rules of interconnection to the electricity grid. To improve the quality of the output waveform of the grid-connected inverter, Multilevel Converters (MC) with selective harmonic elimination modulation technique can be used. This paper presents a single-phase nine level grid-connected inverter with DC/DC input stages. The obtained switching angles for THD minimization are independent of the modulation index. The proposed control technique is able to regulate both the active and the reactive power, acting respectively on the control of the DC/DC and the inverter stages.

This work explores the influence of climate changes on the proper selection of asphalt binder for pavement construction purposes, according to the Performance Grade (PG) defined in the SUPERPAVE specifications. Based on temperature data at national level, it is possible to obtain thematic maps for the whole Italian territory, which is extremely useful for technicians and pavement engineers for selection of asphalt binder for road construction purposes. Furthermore, the statistical significant temperature trends’ knowledge enables deriving thematic maps which allows to include the effects of climate change in the asphalt binder design. It is argued that, due to climate change, the binders to be selected may be different from those commonly selected at the design stage of the infrastructure, since likely higher temperature determine more demanding constraints. The comparison among the PG grades necessary for covering the needs for construction in the different regions of Italy also call for highly performing binders, such as those obtained via specific modification with polymers. This will also imply the need for even more performing materials, in terms of mechanical properties and durability, to be used for modification of neat asphalt as well as the need for defining new specification and testing methods, specifically valid for these modified materials.

Runoff data knowledge is of fundamental importance for a wide range of hydrological, ecological, and socioeconomic applications. The reconstruction of annual runoff is a fundamental task for several activities related to water resources management, especially for ungauged basins. At catchment scales, the Budyko's framework provides an extremely useful and, in some cases, accurate estimation of the long-term partitioning of precipitation into evapotranspiration and runoff as a function of the prevailing climatic conditions. Recently the same long-term partitioning rules have been successfully used to describe water partitioning also at the annual scale and calculate the annual runoff distribution within a simple analytic framework in arid and semi-arid basins. One of the main advantages of the latter method is that only annual precipitation and potential evapotranspiration statistics, and the Fu's equation parameter omega are required to obtain the annual runoff probability distribution. The aim of this study is to test the limit and potentialities of the aforementioned method under different climatic conditions. To this aim, the model is applied to more than four hundred basins located in the United States. Catchments were grouped into five different samples, following the subdivision of the continental region in five homogeneous climatic zones according to Koppen-Geiger classification. The theoretical probability distribution of annual runoff at each basin has been compared with that derived from historical observations. The results confirm the capability of the tested technique to reproduce the empirical annual runoff distributions with similar and satisfactory performances across different areas, revealing a good option also in cases characterized by climate and hydrological conditions very different from those hypothesized during the original analytical model design, thus extending the geographical and conceptual limits of applicability of the framework.

In the last years different partial discharge (PD) measuring techniques have been developed because PD diagnostic is the most widely tool to evaluate the insulation condition of a power cable. Recently non-conventional methods and sensors have been used in order to reach improved results in PD measurements. The purpose of this work is to perform measurements that allow to study the variation of pulses when they travel along a MV cable and to locate the pulse source through the time arrival difference of the pulses obtained from two sensors installed separately.

Based on the inductive power transfer (IPT), the contactless approach allows safe and comfortable operations of battery charging for Electric Vehicles (EVs). In this paper, a contactless system particularly suitable for E-bike battery charging is proposed. A practical realization of the system has been carried out, aiming at the system evaluation in terms of working and efficiency. Through a phase shift modulation, a power regulation has been implemented. The target power level is 100 W.

This work describes the electrical characterization of CIG(S,Se) 2 sub-modules in order to compare the related performances with those obtained from traditional silicon photovoltaic modules. This characterization has been performed through means of a test bench, mainly composed by a solar simulator equipment, allowing the determination of the parameters of the prototypes under test at different irradiances and temperatures.

Multilevel Power Inverters are now often used to convert DC to AC voltage waveform. This kind of converter allows high power quality with low output harmonics and lower commutation losses with respect to the traditional ones in order to optimize this aspect. This paper presents a novel simulation analysis of the Multicarrier Sinusoidal Pulse Width Modulation (MC SPWM) techniques B-Spline functions based to control the switches of five-level single-phase cascaded H-bridge inverter. In order to verify the performance of the converter, the harmonic content of the voltage due to modulation techniques has been taken into account. Results highlight the comparison between different B-Spline functions.

The contactless solution is increasingly spreading as method of battery charging for Electric Vehicles (EVs). The standard technology of contactless EV battery charging is based on the Inductive Power Transfer (IPT) between two coupled coils, one connected to the electrical grid and the other one connected to the rechargeable battery. The IPT provides benefits in terms of safety and comfort, due to the absence of a plug-in operation. In this paper, an overview on the IPT applied to the battery charging of electric bicycles is provided, with some general considerations on the technical implications. Moreover, a prototype of contactless battery charging for E-bikes is proposed and described.

This paper presents a comparison of the performances between IPMSMs (Interior Permanent Magnet Synchronous Machine) with a symmetrical and with two different types of unsymmetrical windings. The aim is to demonstrate that the adoption of slightly unsymmetrical windings does not significantly affect the performances of the machines, both in terms of cogging torque and torque/load angle characteristics, providing also the advantage of a higher possibility of choice in terms of slot number/poles ratio. More in particular, an IPMSM model (named IPMSM-1) derived from a commercial geometry equipped with a symmetrical winding is analyzed by using a Finite Element Method (FEM) approach. The simulation results regarding the cogging torque trend, the static characteristics and the related harmonic analysis are shown and discussed. Afterwards, two other IPMSM models with unsymmetrical windings are obtained by modifying the IPMSM-1 stator structure, but maintaining the same rotor configuration. FEM analysis are carried out also for these geometries and the related simulation results are compared with those obtained for the IPMSM-1 model. From this comparison it can be stated that the equipment of slightly unsymmetrical windings can be a viable choice during the design process of rotating electrical machines.

This paper presents the comparison between the cogging torques produced by four IPMSGs (Interior Permanent Magnet Synchronous Generators) with different stator winding configurations. More in detail, an IPMSG model, which is derived from a commercial geometry, is analyzed through means of a FEM (Finite Element Method) approach. Then, three more structures are determined and analyzed by adequately changing the number of stator slots of the basic IPMSG stator structure and by maintaining the same rotor configuration. From the obtained simulation results, the cogging torque components for each structure are determined and compared. From this comparison, it can be stated that the use of dissymmetric windings does not affect significantly the generated cogging torque.

The goal of this work is to predict e-mobility trends which are essential for understanding the market and the infrastructure development over the next years. Nowadays among the many and different standards and rules there are two charging categories for electric vehicles: High power DC and AC charging modes. It will be interesting to see which technology will prevail in the next few years and if the charging mode option on a given EV affects its sales performance. This study presents the current e-mobility scenario in Norway and Italy, in particular analyzing: EV technical and commercial features, electric vehicle market related national incentive policies, technical and diffusion connector type and charging mode. In conclusion, on the basis of the existing history and analysis of the data available, this work will present a considered opinion on the probable development of this expanding niche market.

This paper presents an innovative lead acid battery, based on nanostructured active materials. Both charging time and specific energy are greatly enhanced in comparison with commercial lead acid battery. Starting from the extremely valuable performances of the nanostructured battery, also a circuital model, for application in electric vehicle traction, has been specifically developed. The circuital model has demonstrated that an enhanced nanostructured battery allows an increase of traveled distance by electric vehicles.

This article addresses the problem of the choice of a generation system to be implemented to reduce the impact of charging electric vehicles at University. Based on the behaviour of the student population, it is identified the electrical load. Two possible solutions are evaluated in order to manage the peak load: an orientation of the panels in order to increase the power at defined time and the use of storage system. The main strength and weakness points of two systems are investigated by taking into account the Levelized Cost of Energy.

The main objective of this paper is to study and analyse the voltage output waveform of a multilevel inverter, to suggest a new approach for harmonic mitigation improving the converter performance. These last type of converters represent a new technology in the field of DC/AC electrical energy conversion, presenting advantages respect to the traditional converters. In fact, the multilevel power converters present a low harmonic content and a high voltage level. The paper considers a five-level single-phase cascaded H-bridge inverter and fundamental frequency modulation techniques. The voltage waveform analysis has allowed to identify a working area of the converter where there are lowest values of the considered harmonic amplitude. The simulated behaviour of the model of the converter, with the logic piloting gate signals, has been obtained in Matlab-Simulink environment.

This paper shows the technical and economical evaluation of the application of a reconfiguration system for photovoltaic (PV) plants, considering the incentives system in some European Union countries. The reconfiguration system is an alternative to the distributed maximum power point tracking technique which used to increase the power production in the PV plants under the mismatch phenomenon. The reconfiguration techniques employ a microprocessor-based or field-programmable gate array-based system that modifies the layout of the PV plant through the change of the connections among modules. After having presented the main features working of the PV reconfiguration system allowing the improvement of the efficiency of the same plant and the relevant installation, the main strength and weakness points of the investment are evidenced in relation to different incentives policies in some country of UE.

Solar photovoltaic plants power output forecasting using machine learning techniques can be of a great advantage to energy producers when they are implemented with day-ahead energy market data. In this work a model was developed using a supervised learning algorithm of multilayer perceptron feedforward artificial neural network to predict the next twenty-four hours (day-ahead) power of a solar facility using fetched weather forecast of the following day. Each set of tested network configuration was trained by the historical power output of the plant as a target. For each configuration, one hundred networks ensembles was averaged to give the ability to generalize a better forecast. The trained ensembles performances were analyzed using statistical indicators. The best-performing model ensembles were eventually used to predict power from the automatically fetched weather data.

This paper presents the performance comparison of PV windows with the purpose of tracing the behavior of next-generation systems, which could favor architectonical integration. More in detail, a dye sensitized solar cell (DSSC) and blue and grey thin film silicon panels have been analyzed. The systems can be placed behind a window or behind a wall of glass blocks. The three generation systems are then compared in terms of both efficiency and Fill Factor.

The FPGA represents a valid solution for the design of control systems for inverters adopted in the field of PV systems because of their high flexibility of use. This paper presents an experimental analysis of the MC SPWM techniques for a three-phase, five-level, cascaded H-Bridge inverter with FPGA controller-based. Several control algorithms are implemented by means of the VHDL programming language and the output voltage waveforms obtained from the main PWM techniques are compared in terms of THD%. Simulation and experimental results are analysed, compared and discussed.

Performances and duration of the new generation of high voltage power electronic components are dependent on dielectric materials aim to insulating their internal terminals. The presence of defects, some due to faults generated during the manufacturing process, but also due to the internal design of layers and connections, can cause local enhancements of electric field and consequently possible activity of partial discharges phenomena or other effects (aging, tracking) that may result in reduction of device reliability. Furthermore, the usage of unconventional voltage waveforms, like square waves or pulse width modulated waves, additionally increases the electrical aging of the insulation system as compared to conventional sinusoidal waves.

This paper presents an economic analysis of the effectiveness of Dynamic Reconfiguration Systems (DRS) for PV plants in dependence of the incentive policies offered by several countries of the European Community. This evaluation has been achieved by means of the NPV (Net Present Value) and through the comparison between Bulgaria, Romania, Greece and Croatia. From the obtained results, it can be stated that the adoption of reconfiguration systems, in certain cases, can be a convenient solution.