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5 results on '"University of Memphis (U of M)"'

1. Oromandibular Dystonia: A Clinical Examination of 2,020 Cases

Author

Laura M. Scorr, Stewart A. Factor, Sahyli Perez Parra, Rachel Kaye, Randal C. Paniello, Scott A. Norris, Joel S. Perlmutter, Tobias Bäumer, Tatiana Usnich, Brian D. Berman, Marie Mailly, Emmanuel Roze, Marie Vidailhet, Joseph Jankovic, Mark S. LeDoux, Richard Barbano, Florence C. F. Chang, Victor S. C. Fung, Sarah Pirio Richardson, Andrew Blitzer, H. A. Jinnah, Emory University [Atlanta, GA], Rutgers University [Newark], Rutgers University System (Rutgers), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), Lübeck University of Applied Sciences, University of Colorado Anschutz [Aurora], Hôpital de la Fondation Ophtalmologique Adolphe de Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Baylor College of Medecine, University of Memphis (U of M), University of Rochester Medical Center (URMC), The University of Sydney, and The University of New Mexico [Albuquerque]

Subjects
Pediatrics, medicine.medical_specialty, Physical examination, 03 medical and health sciences, jaw, 0302 clinical medicine, Quality of life, tongue, 030225 pediatrics, medicine, RC346-429, Depression (differential diagnoses), Original Research, Dystonia, treatment, medicine.diagnostic_test, business.industry, medicine.disease, Oromandibular dystonia, botulinum (neuro)toxin, Botulinum toxin, 3. Good health, Neurology, Cohort, Etiology, dystonia, Neurology. Diseases of the nervous system, Neurology (clinical), business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, 030217 neurology & neurosurgery, medicine.drug
Abstract

Objective: The goal of this study is to better characterize the phenotypic heterogeneity of oromandibular dystonia (OMD) for the purpose of facilitating early diagnosis.Methods: First, we provide a comprehensive summary of the literature encompassing 1,121 cases. Next, we describe the clinical features of 727 OMD subjects enrolled by the Dystonia Coalition (DC), an international multicenter cohort. Finally, we summarize clinical features and treatment outcomes from cross-sectional analysis of 172 OMD subjects from two expert centers.Results: In all cohorts, typical age at onset was in the 50s and 70% of cases were female. The Dystonia Coalition cohort revealed perioral musculature was involved most commonly (85%), followed by jaw (61%) and tongue (17%). OMD more commonly appeared as part of a segmental dystonia (43%), and less commonly focal (39%) or generalized (10%). OMD was found to be associated with impaired quality of life, independent of disease severity. On average, social anxiety (LSA score: 33 ± 28) was more common than depression (BDI II score: 9.7 ± 7.8). In the expert center cohorts, botulinum toxin injections improved symptom severity by more than 50% in ~80% of subjects, regardless of etiology.Conclusions: This comprehensive description of OMD cases has revealed novel insights into the most common OMD phenotypes, pattern of dystonia distribution, associated psychiatric disturbances, and effect on QoL. We hope these findings will improve clinical recognition to aid in timely diagnosis and inform treatment strategies.

Published
2021
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2. DNA methylation and body mass index from birth to adolescence : meta-analyses of epigenome-wide association studies

Author

Anni Heiskala, Gwen Tindula, Samuli Tuominen, Anne P. Starling, Vincent W. V. Jaddoe, Samantha Lent, Katri Räikkönen, Carlos Ruiz-Arenas, Thorkild I. A. Sørensen, Dariusz Gruszfeld, Cathrine Hoyo, Johanna Lepeule, Tong Gong, Erik Melén, Ellen A. Nohr, Ivana V. Yang, John W. Holloway, Jari Lahti, Susan Ewart, Mariona Bustamante, Veit Grote, Marjo-Riitta Järvelin, Brenda Eskenazi, Philip E. Melton, Catarina Almqvist, Robert Karlsson, Elisabeth B. Binder, Weiming Zhang, Dereje D. Jima, Dana Dabelea, Maria C. Magnus, Lucas A. Salas, Jean-Paul Langhendries, Trevor A. Mori, Syed Hasan Arshad, Peter Rzehak, Florianne O L Vehmeijer, Leanne K. Küpers, Inger Kull, Caroline L Relton, Judith M. Vonk, Emily Oken, Vilhelmina Ullemar, Cancan Qi, Wilfried Karmaus, Martine Vrijheid, Darina Czamara, Peter L. Molloy, Anna Bergström, Olena Gruzieva, Hongmei Zhang, Wenche Nystad, Lu Gao, Marie-France Hivert, Beverly S. Muhlhausler, Rachel L. Maguire, Lawrence J. Beilin, Jason P. Ross, Eva Corpeleijn, Faisal I. Rezwan, Sylvain Sebert, Siri E. Håberg, Gemma C Sharp, Cheng-Jian Xu, Natalia Ferre, Gerard H. Koppelman, Leda Chatzi, Nina Holland, Janine F. Felix, Berthold Koletzko, Stephanie J. London, Christian M. Page, Harold Snieder, Carrie V. Breton, Susan K. Murphy, Rae-Chi Huang, Claire Monnereau, Elvira Verduci, Karen Huen, Geòrgia Escaramís, Gunn Marit Aasvang, Andrea A. Baccarelli, Paul Yousefi, Sarah E. Reese, Sheryl L. Rifas-Shiman, Department of Psychology and Logopedics, Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Bristol [Bristol], University of Groningen [Groningen], Geisel School of Medicine at Dartmouth, Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Boston University School of Medicine (BUSM), Boston University [Boston] (BU), North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC), University of California [Berkeley], University of California, National Institutes of Health [Bethesda] (NIH), University Medical Center Groningen [Groningen] (UMCG), Groningen Research Institute for Asthma and COPD (GRIAC), Karolinska Institutet [Stockholm], Centre for Occupational and Environmental Medicine [Stockholm, Sweden] (Region Stockholm), Norwegian Institute of Public Health [Oslo] (NIPH), Oslo University Hospital [Oslo], Cranfield University, University of Southampton, Curtin University [Perth], Planning and Transport Research Centre (PATREC), The University of Western Australia (UWA), University of South-Eastern Norway (USN), University of Southern Denmark (SDU), University of Barcelona, Universitat de Girona [Girona], Universitat de Girona (UdG), Dr von Hauner Children's Hospital [Munich, Germany], Ludwig-Maximilians-Universität München (LMU), University of Oulu, University of Helsinki, University of Southern California (USC), CSIRO - North Ryde Site [New SouthWales, Australia], Colorado School of Public Health [Aurora, CO, USA] (CSPH), University of Colorado Anschutz [Aurora], Max Planck Institute of Psychiatry, Max-Planck-Gesellschaft, Emory University School of Medicine, Emory University [Atlanta, GA], Keck School of Medicine [Los Angeles], Michigan State University [East Lansing], Michigan State University System, Universitat Rovira i Virgili, Children’s Memorial Health Institute [Warsaw, Poland] (CMHI), Sachs’ Children and Youth Hospital [Stockholm, Sweden], Clinique Saint-Vincent [Liège-Rocourt,Belgium] (Groupe santé CHC), Université Grenoble Alpes (UGA), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Duke University Medical Center, Harvard Medical School [Boston] (HMS), University of Milan, Helmholtz Centre for Infection Research (HZI), Centre for Experimental and Clinical Infection Research [Hanover] (TWINCORE), University of Colorado [Colorado Springs] (UCCS), Jewish General Hospital, University of Memphis (U of M), CSIRO ADELAIDE AUS, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), University of Turku, Karolinska University Hospital [Stockholm], Imperial College London, Brunel University London [Uxbridge], Oulu University Hospital [Oulu], University of Copenhagen = Københavns Universitet (KU), The David Hide Asthma and Allergy Research Centre [Southampton, UK], St Mary's Hospital-University Hospital Southampton NHS Foundation Trust, Beatrix Children's Hospital [Groningen, Pays-Bas], Massachusetts General Hospital [Boston], Université de Sherbrooke (UdeS), Mailman School of Public Health Columbia University [New-York], European Project: 733206,H2020,H2020-SC1-2016-RTD,LIFECYCLE(2017), Epidemiology, Pediatrics, Life Course Epidemiology (LCE), HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany., University of California [Berkeley] (UC Berkeley), University of California (UC), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Università degli Studi di Milano = University of Milan (UNIMI), University of Copenhagen = Københavns Universitet (UCPH), BARBAGALLO, Maïlys, and Early-life stressors and LifeCycle health - LIFECYCLE - - H20202017-01-01 - 2021-12-31 - 733206 - VALID

Subjects
Male, 0301 basic medicine, Pediatric Obesity, [SDV]Life Sciences [q-bio], CHILDHOOD, LOCI, Physiology, CHILDREN, Cardiovascular, Oral and gastrointestinal, Epigenesis, Genetic, Epigenome, 0302 clinical medicine, Pregnancy, 2.1 Biological and endogenous factors, Medicine, PROMOTER METHYLATION, Childhood obesity, CORD BLOOD, Aetiology, Child, Genetics (clinical), Body mass index, Cancer, Genetics & Heredity, Pediatric, 2. Zero hunger, DNA methylation, 1184 Genetics, developmental biology, physiology, Methylation, Fetal Blood, [SDV] Life Sciences [q-bio], Stroke, Child, Preschool, 030220 oncology & carcinogenesis, OBESITY, Molecular Medicine, Female, Epigenetics, ADIPOSITY, social and economic factors, Life Sciences & Biomedicine, Adolescent, Clinical Sciences, 03 medical and health sciences, BMI, Genetic, 2.3 Psychological, Genetics, Humans, LMS METHOD, Obesity, Preschool, Molecular Biology, Metabolic and endocrine, Nutrition, Genetic association, 0604 Genetics, Science & Technology, business.industry, Research, Prevention, Human Genome, Parturition, 1103 Clinical Sciences, medicine.disease, Cross-Sectional Studies, 030104 developmental biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, DISCOVERY, CpG Islands, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Epigenesis
Abstract

Background DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unknown. More insight into this relationship at younger ages may have implications for future prevention of obesity and its related traits. Methods We examined whether DNA methylation in cord blood and whole blood in childhood and adolescence was associated with BMI in the age range from 2 to 18 years using both cross-sectional and longitudinal models. We performed meta-analyses of epigenome-wide association studies including up to 4133 children from 23 studies. We examined the overlap of findings reported in previous studies in children and adults with those in our analyses and calculated enrichment. Results DNA methylation at three CpGs (cg05937453, cg25212453, and cg10040131), each in a different age range, was associated with BMI at Bonferroni significance, P −7, with a 0.96 standard deviation score (SDS) (standard error (SE) 0.17), 0.32 SDS (SE 0.06), and 0.32 BMI SDS (SE 0.06) higher BMI per 10% increase in methylation, respectively. DNA methylation at nine additional CpGs in the cross-sectional childhood model was associated with BMI at false discovery rate significance. The strength of the associations of DNA methylation at the 187 CpGs previously identified to be associated with adult BMI, increased with advancing age across childhood and adolescence in our analyses. In addition, correlation coefficients between effect estimates for those CpGs in adults and in children and adolescents also increased. Among the top findings for each age range, we observed increasing enrichment for the CpGs that were previously identified in adults (birth Penrichment = 1; childhood Penrichment = 2.00 × 10−4; adolescence Penrichment = 2.10 × 10−7). Conclusions There were only minimal associations of DNA methylation with childhood and adolescent BMI. With the advancing age of the participants across childhood and adolescence, we observed increasing overlap with altered DNA methylation loci reported in association with adult BMI. These findings may be compatible with the hypothesis that DNA methylation differences are mostly a consequence rather than a cause of obesity.

Published
2020
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3. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Author

Marjo-Riitta Järvelin, Catherine Allard, Andres Cardenas, Olivia Solomon, Barbara Heude, Vincent W. V. Jaddoe, Wilfried Karmaus, Terence Dwyer, Katri Räikkönen, Darina Czamara, Olena Gruzieva, Isabella Annesi-Maesano, Manolis Kogevinas, Simon Kebede Merid, Hongmei Zhang, Wenche Nystad, Florianne O L Vehmeijer, Erik Melén, Susan Ewart, Lu Gao, Michelle Plusquin, Sarah E. Reese, Munawar Hussain Soomro, Marie-France Hivert, Zdenko Herceg, Andrea A. Baccarelli, Janine F. Felix, Luigi Bouchard, Göran Pershagen, Jordi Sunyer, Alexei Novoloaca, Joseph L. Wiemels, Elisabeth B. Binder, John P. Newnham, Thorkild I. A. Sørensen, Sheryl L. Rifas-Shiman, Ellen A. Nohr, Nabila Kazmi, Carrie V. Breton, Ashok Kumar, Juha Kere, Nina Holland, Josep M. Antó, Debbie A Lawlor, Karen Huen, Rae-Chi Huang, Inger Kull, Brenda Eskenazi, Paolo Vineis, Matthias Wielscher, Monica Cheng Munthe-Kaas, Catarina Almqvist, Cilla Söderhäll, Lucas A. Salas, Jean Bousquet, Alvin T. Kho, Patrice Perron, Petter Brodin, Martine Vrijheid, Kelan G. Tantisira, Per Magnus, Scott T. Weiss, Faisal I. Rezwan, Nour Baïz, Stephanie J. London, Gemma C Sharp, Phillip E. Melton, Emily Oken, Luigi Gagliardi, John W. Holloway, Gerard H. Koppelman, Siri E. Håberg, Caroline L Relton, Leanne K. Küpers, Denise Anderson, Jari Lahti, Tim S. Nawrot, Mariona Bustamante, Priyadarshini Kachroo, S. Hasan Arshad, Dawn L. DeMeo, Liesbeth Duijts, Sylvain Sebert, Shanshan Zhao, Eva Corpeleijn, Judith M. Vonk, Christian M. Page, Harold Snieder, Pooja Jain, Akram Ghantous, Anna Bergström, Cheng-Jian Xu, Ritu Roy, Rezwan, Faisal Ibne/0000-0001-9921-222X, Holloway, John/0000-0001-9998-0464, Lawlor, Debbie A/0000-0002-6793-2262, Salas, Lucas A/0000-0002-2279-4097, Cardenas, Andres/0000-0003-2284-3298, Sharp, Gemma/0000-0003-2906-4035, Lifestyle Medicine (LM), Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Doctoral Programme in Cognition, Learning, Instruction and Communication, Department of Psychology and Logopedics, Developmental Psychology Research Group, Faculty of Medicine, University of Helsinki, STEMM - Stem Cells and Metabolism Research Program, Juha Kere / Principal Investigator, Research Programs Unit, HUS Helsinki and Uusimaa Hospital District, UNIVERSITY OF OULU, Salvy-Córdoba, Nathalie, Karolinska Institutet [Stockholm], Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, International Agency for Cancer Research (IACR), MRC Integrative Epidemiology Unit [Bristol, Royaume-Uni] (MRC IEU), University of Bristol [Bristol], Bristol Medical School, Wageningen University and Research [Wageningen] (WUR), University of Groningen [Groningen], Boston Children's Hospital, Harvard Medical School [Boston] (HMS), University of California [San Francisco] (UC San Francisco), University of California (UC), Helen Diller Family Comprehensive Cancer Center [San Francisco], Southern California University of Health Sciences (SCU), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), NIHR Biomedical Research Centre [London], Guy's and St Thomas' NHS Foundation Trust-King‘s College London, Imperial College London, Hasselt University (UHasselt), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Faculté de médecine et des sciences de la santé [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Geisel School of Medicine at Dartmouth, Cranfield University, University of Memphis (U of M), University of Oulu, Department of Biology and Biocenter Oulu, Max Planck Institute of Psychiatry, Max-Planck-Gesellschaft, Harvard Pilgrim Health Care Institute, Curtin University [Bentley, WA, Australie], The University of Western Australia (UWA), NIHR Bristol Biomedical Research Centre, Centre for Occupational and Environmental Medicine [Stockholm, Sweden] (Region Stockholm), University of Southern California (USC), University of California [Berkeley] (UC Berkeley), USL Tuscany Northwest, NIHR Health Protection Research Unit, Partenaires INRAE, University Hospitals Leuven [Leuven], University Medical Center Groningen [Groningen] (UMCG), CHUS – Centre Hospitalier Universitaire de Sherbrooke [Sherbrooke, QC, Canada], University of Southern Denmark (SDU), Michigan State University [East Lansing], Michigan State University System, National Institute of Environmental Health Sciences [Durham] (NIEHS-NIH), National Institutes of Health [Bethesda] (NIH), Norwegian Institute of Public Health [Oslo] (NIPH), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Turku Institute for Advanced Studies, Columbia Mailman School of Public Health, Columbia University [New York], Telethon KIDS Institute, Brigham and Women’s Hospital [Boston, MA], Département des Sciences Fondamentales [Saguenay, QC, Canada], Université du Québec à Chicoutimi (UQAC), Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), University of Copenhagen = Københavns Universitet (UCPH), University of Southampton, The David Hide Asthma and Allergy Research Centre, St Mary's Hospital-University Hospital Southampton NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, Nuffield Department of Women's and Reproductive Health (NDWRH), University of Oxford- John Radcliffe Hospital [Oxford University Hospital], Murdoch Children's Research Institute (MCRI), Emory University School of Medicine, Emory University [Atlanta, GA], Brigham and Women's Hospital [Boston], Karolinska Institutet Science Park, Sachs' Children's Hospital, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Research Team on Early life Origins of Health (EarOH), Oslo University Hospital [Oslo], Brigham & Women’s Hospital [Boston] (BWH), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Basel (Unibas), Swiss Tropical and Public Health Institute [Basel], Astrid Lindgren Children's Hospital, Karolinska University Hospital [Stockholm], School of Public Health [Berkeley], University of California (UC)-University of California (UC), Beatrix Children's Hospital, Folkhälsan Research Center, Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-17165 Sweden., Massachusetts General Hospital [Boston], Erasmus MC other, and Pediatrics

Subjects
Male, Physiology, MESH: Epigenome, Fetal Development, Epigenome, 0302 clinical medicine, MESH: Child, MATERNAL SMOKING, CORD BLOOD, Aetiology, Child, Lung, Genetics & Heredity, 1184 Genetics, developmental biology, physiology, ASSOCIATION, ALSPAC, 3. Good health, Child, Preschool, 030220 oncology & carcinogenesis, Epigenetics, Infant, Premature, Clinical Sciences, Development, 03 medical and health sciences, Clinical Research, Genetics, Humans, Transcriptomics, Premature, Molecular Biology, MESH: Adolescent, 0604 Genetics, Pregnancy, MESH: Humans, Science & Technology, MESH: Child, Preschool, lcsh:R, PRENATAL ARSENIC EXPOSURE, Infant, DNA, DNA Methylation, medicine.disease, 030104 developmental biology, Genetic Loci, COHORT PROFILE, MESH: Female, 0301 basic medicine, MESH: Premature Birth, Nutrition and Disease, lcsh:Medicine, Reproductive health and childbirth, MESH: DNA Methylation, Voeding en Ziekte, 2.1 Biological and endogenous factors, RUNX3 GENE, Genetics (clinical), RISK, Pediatric, MESH: Infant, Newborn, MESH: DNA, Gestational age, Premature birth, Cord blood, DNA methylation, Premature Birth, Molecular Medicine, Female, Life Sciences & Biomedicine, MESH: Fetal Development, MESH: Infant, Premature, lcsh:QH426-470, Adolescent, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, MESH: Genetic Loci, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, medicine, Preschool, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Fetus, business.industry, Research, Human Genome, Infant, Newborn, CHILDHOOD ASTHMA, 1103 Clinical Sciences, Preterm birth, Perinatal Period - Conditions Originating in Perinatal Period, Newborn, MESH: Male, lcsh:Genetics, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, 3111 Biomedicine, WEIGHT, business
Abstract

Background Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods We performed meta-analysis of Illumina’s HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4–18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results We identified 8899 CpGs in cord blood that were associated with gestational age (range 27–42 weeks), at Bonferroni significance, P − 7, of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects.

Published
2020
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4. Biologically plausible trends suggesting that a <scp>low‐protein</scp> diet may enhance the effect of flozination caused by the sodium‐glucose cotransporter‐2 inhibitor dapagliflozin on albuminuria

Author

Denis Fouque, Kamyar Kalantar-Zadeh, Srinivasan Beddhu, Csaba P. Kovesdy, Holly Kramer, CarMeN, laboratoire, University of California [Irvine] (UC Irvine), University of California (UC), Long Beach Medical Center [Long Beach, California, USA] (LBMC), University of Utah, University of Memphis (U of M), Loyola University [Chicago], Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
[SDV]Life Sciences [q-bio], Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Protein-Restricted, Pharmacology, Sodium-Glucose Transporter 2 Inhibitors/therapeutic use, chemistry.chemical_compound, Endocrinology, Glucosides, Low-protein diet, Internal Medicine, medicine, Albuminuria, Humans, Sodium-Glucose Cotransporter 2 Inhibitor, Benzhydryl Compounds, Dapagliflozin, ComputingMilieux_MISCELLANEOUS, Diabetes Mellitus, business.industry, Sodium, Diet, [SDV] Life Sciences [q-bio], Glucose, Type 2/drug therapy, chemistry, medicine.symptom, business
Abstract

International audience; No abstract available

Published
2021
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5. NICE: Network-oriented Information-centric Centrality for Efficiency in Cache Management

Author

Junaid Ahmed Khan, J.J. Garcia-Luna-Aceves, Yacine Ghamri-Doudane, Cedric Westphal, University of Memphis (U of M), Huawei Technologies [Santa Clara], University of California [Santa Cruz] (UCSC), University of California, Laboratoire Informatique, Image et Interaction - EA 2118 (L3I), and Université de La Rochelle (ULR)

Subjects
Computer science, Graph centrality, business.industry, Nice, Graph Centrality, 020302 automobile design & engineering, 020206 networking & telecommunications, Context (language use), 02 engineering and technology, Network connectivity, Cache management, ICN, Cache Management, [INFO.INFO-NI]Computer Science [cs]/Networking and Internet Architecture [cs.NI], 0203 mechanical engineering, Content Offload-ing, Server, Metric (mathematics), 0202 electrical engineering, electronic engineering, information engineering, Centrality, business, computer, Content Offloading, Computer network, computer.programming_language
Abstract

International audience; All Information-Centric Networking (ICN) architectures proposed to date aim at connecting users to content directly , rather than connecting clients to servers. Surprisingly , however, although content caching is an integral of any information-Centric Network, limited work has been reported on information-centric management of caches in the context of an ICN. Indeed, approaches to cache management in networks of caches have focused on network connectivity rather than proximity to content. We introduce the Network-oriented Information-centric Centrality for Efficiency (NICE) as a new metric for cache management in information-centric networks. We propose a method to compute information-centric centrality that scales with the number of caches in a network rather than the number of content objects, which is many orders of magnitude larger. Furthermore, it can be pre-processed offline and ahead of time. We apply the NICE metric to a content replacement policy in caches, and show that a content replacement based on NICE exhibits better performances than LRU and other policies based on topology-oriented definitions of centrality.

Published
2018
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