1. Selective aortic arch perfusion versus open cardiac massage in exsanguination cardiac arrest: A comparison of coronary pressure dynamics in swine
- Author
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Marta J. Madurska, Todd E. Rasmussen, David Poliner, Joseph Edwards, Neerav Patel, Joseph M. White, Hossam Abdou, Michael J Richmond, Jonathan J. Morrison, and Thomas M. Scalea
- Subjects
Aortic arch ,medicine.medical_specialty ,Resuscitation ,business.industry ,medicine.medical_treatment ,Atrial Pressure ,Hemodynamics ,030208 emergency & critical care medicine ,030204 cardiovascular system & hematology ,Emergency Nursing ,03 medical and health sciences ,0302 clinical medicine ,Blood pressure ,medicine.artery ,Internal medicine ,Emergency Medicine ,medicine ,Cardiology ,Coronary perfusion pressure ,Thoracotomy ,Cardiology and Cardiovascular Medicine ,business ,Perfusion - Abstract
To evaluate the mean aortic-right atrial pressure (AoP-RAP) gradients and mean coronary perfusion pressures (CPPs) observed during open cardiac massage (OCM) versus those obtained with selective aortic arch perfusion (SAAP) in post-mortem hypovolemic swine.Post-mortum, male swine, utilized in prior studies of hemorrhage, were included in the study. Animals were bled ∼25-50% of circulating volume prior to death. Animals either underwent clamshell thoracotomy and OCM immediately after death was confirmed (n = 6) or underwent SAAP within 5-15 min of death (n = 6). Aortic root and right atrial pressures were recorded continuously during each method of resuscitation using solid state blood pressure catheters. Representative five beat samples were extracted; short, similarly timed segments of SAAP were also extracted. Mean AoP-RAP gradient and CPPs were calculated and compared.Mean AoP-RAP gradient and CPP were significantly higher in SAAP animals compared to OCM animals (mean ± SD; 29.1 ± 8.4 vs. 24.5 ± 5.0, p 0.001; 28.9 ± 8.5 vs. 9.9 ± 6.0, p 0.001). Mean CPP was not significantly different from mean AoP-RAP gradient in SAAP animals (p = 0.92); mean CPP was significantly lower than mean AoP-RAP gradient in OCM animals (p 0.001). While 97% of SAAP segments had a CPP 15 mmHg, only 17% of OCM segments had a CPP 15 mmHg (p 0.001).SAAP appears to create a more favorable and efficient hemodynamic profile for obtaining ROSC when compared to OCM in this preclinical porcine study.
- Published
- 2021