1. Ultraviolet A rush hardening for chronic actinic dermatitis: Pilot treatment outcomes
- Author
-
Wei Rong, Hui-Zhong Li, Tianjing Wang, Jialin Zhang, Li Li, and Yang-Yang Gong
- Subjects
medicine.medical_specialty ,Ultraviolet Rays ,Treatment outcome ,Solar urticaria ,Photodermatosis ,Pilot Projects ,Extent of disease ,Dermatology ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Chronic actinic dermatitis ,Photosensitivity Disorders ,Prospective Studies ,Prospective cohort study ,business.industry ,General Medicine ,Ultraviolet a ,medicine.disease ,Treatment Outcome ,030220 oncology & carcinogenesis ,Quality of Life ,Phototesting ,business - Abstract
Chronic actinic dermatitis (CAD) is a common debilitating photodermatosis. Patients often have to completely avoid outdoor activities, which severely impacts their quality of life. Phototherapy is effective for CAD and seems to increase patients' tolerance towards sunlight and consequently decrease the extent of disease. Unfortunately, the slower onset and time-consuming nature of phototherapy limits the clinical application. Considering the effectiveness and time-saving nature of ultraviolet (UV)-A rush hardening in solar urticaria, we performed a pilot study to determine whether UV-A rush hardening is effective in CAD. Six patients with CAD were exposed to multiple sessions of UV-A for 4-5 days at 1-h intervals/day. Subsequently, maintenance UV-A exposure was performed at 1-2-week intervals. Phototesting at baseline showed that three patients were sensitive to both UV-A and -B, and the other three patients only showed UV-A sensitivity. All of the patients responded well to UV-A rush hardening and four (67%) maintained a good remission status after 1 year. The results of this pilot study suggest that UV-A rush hardening phototherapy is effective and well tolerated in the treatment of CAD, while future larger prospective studies using objective scores of disease activity and quality of life are needed.
- Published
- 2020