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'Yotsuboshi', a seed propagating type F1 hybrid strawberry cultivar adaptable for year-round production, was developed from the collaborative breeding program including four institutes of Mie, Kagawa and Chiba prefectures and National Agriculture and Food Research Organization (NARO) in Japan. The behavior of flower initiation is quite unique. 'otuboshi' exhibits stable extra earliness under natural condition with a lower temperature and shorter day-length, while it possesses the ever-bearing gene which results in the induction of flower initiation under long-day condition. Thus 'Yotsuboshi' is adaptable for year-round production including both forcing culture in autumn to spring and summer-autumn cultivation across Japan. 'Yotsuboshi' has several attractive traits such as a clear red fruit color, excellent fruit shape and size, high yielding ability, and superior taste with a high content of sugar and moderate acidity. The practical production system of F1 hybrid seeds and the DNA marker system for certifying the uniformity of seeds have already been established. The seeds and/or plug tray seedlings will be commercially provided from this summer for the member of the 'Research society for seed propagating type strawberries in Japan'.

In today's highly globalised world, protecting human security is a core challenge for political leaders who are simultaneously dealing with terrorism, refugee and migration crises, disease epidemics, and climate change. Promoting universal health coverage (UHC) will help prevent another disease outbreak similar to the recent Ebola outbreak in west Africa, and create robust health systems, capable of withstanding future shocks. Robust health systems, in turn, are the prerequisites for achieving UHC. We propose three areas for global health action by the G7 countries at their meeting in Japan in May, 2016, to protect human security around the world: restructuring of the global health architecture so that it enables preparedness and responses to health emergencies; development of platforms to share best practices and harness shared learning about the resilience and sustainability of health systems; and strengthening of coordination and financing for research and development and system innovations for global health security. Rather than creating new funding or organisations, global leaders should reorganise current financing structures and institutions so that they work more effectively and efficiently. By making smart investments, countries will improve their capacity to monitor, track, review, and assess health system performance and accountability, and thereby be better prepared for future global health shocks.

An arbitrary pattern exposure system has been developed by employing a liquid crystal display (LCD) with 1600 /spl times/ 1200 pixels for the formation of projection images in place of a conventional reticle. The minimum pattern size becomes 11.5 /spl mu/m, which corresponds to the aperture size of each pixel on the LCD. For the purpose of quick turnaround time (TAT), the exposure system was directly connected to the circuit design system with the transmission control protocol/internet protocol network. From the experimental results on patterning of a typical electronic circuit data with the area of 46/spl times/ 46 mm, it was confirmed that the TAT from the output of design data to the finish of the exposure becomes less than 28 min. By using this system, reduction of the production cost in the printed wiring boards fabrication is expected.

A reduction of depth variation in a shallow trench isolation process is desired for obtaining more stable electrical performances of silicon devices. By applying an optimized run-to-run control system to a silicon trench etching process, trench depth variation of the process was reduced. Cp/Cpk of the trench depth of product wafers were improved from 1.10/0.83 to 1.39/1.34 by the control.

This paper describes the 32-Mb and the 64-Mb embedded DRAM core with high efficient redundancy, which is fabricated using 0.13-/spl mu/m triple-well 4-level Cu embedded DRAM technology. Core size of 18.9 mm/sup 2/ and cell efficiency of 51.3% for the 32-Mb capacity, and core size of 33.4 mm/sup 2/ and cell efficiency of 58.1% for the 64-Mb capacity are realized. This core can achieve 230-MHz burst access at 1.0-V power-supply condition by adopting a new data bus architecture: merged shift column redundancy. We implemented four test functions to improve the testability of the embedded DRAM core. It realizes the DRAM core test in a logic test environment.

This paper describes a 32-Mb embedded DRAM macro fabricated using 0.13-/spl mu/m triple-well 4-level Cu embedded DRAM technology, which is suitable for portable equipment of MPEG applications. This macro can operate 230-MHz random column access even at 1.0-V power supply condition. The peak power consumption is suppressed to 198 mW in burst operation. The power-down standby mode, which suppresses the leakage current consumption of peripheral circuitry, is also prepared for portable equipment. With the collaboration of array circuit design and the fine Cu metallization technology, macro size of 18.9 mm/sup 2/ and cell efficiency of 51.3% are realized even with dual interface and triple test functions implemented.

This paper describes the reconstruction of mandibular defects in four oral cancer patients using iliac crest bone grafts and osseointegrated implants. In three patients, reconstructive surgery using a reconstruction plate and free forearm skin flap was performed following tumour and segmental mandibular resection. After 7-9 months, mandibular reconstruction with a free iliac bone graft was carried out. In one patient, reconstructive surgery was performed with vascularized iliac bone grafting with an anterolateral thigh flap at the same time as the tumour resection. Fixtures were placed in the transplanted bone, and abutments were connected 6-9 months later together with vestibuloplasty. Gingival grafts were used to replace the skin flap around abutments. All implants survived throughout the approximately 4-6 years observation time. Marginal bone loss of the graft was originally several millimetres but less than 1.5 mm. Bone loss as well as management of peri-implant soft tissue was also discussed.

The aim of this study was to assess the importance of immunohistochemical thymidylate synthase (TS) expression level as a prognostic marker in tongue cancer patients. In 140 patients with primary squamous cell carcinoma (SCC) of the tongue, intratumoural TS expression was evaluated by immunohistochemistry. The level of TS expression was determined by a semiquantitative scoring system, ranging from 1+ to 3+ according to the ratio of TS-positive cells. Of 140 patients, 64 (45.7%), 49 (35.0%) and 27 (19.3%) were assessed as 1+, 2+ and 3+, respectively. Univariate analyses demonstrated that both disease-free survival (DFS) and overall survival (OS) were significantly lower in patients with a TS 3+ tumour than in those with a TS 1+/2+ tumour (DFS: P = 0.0082, OS: P = 0.0100). In a multivariate analysis using the Cox regression model, cervical lymph-node status and TS expression level were selected as independent factors for DFS and OS. Maintenance adjuvant chemotherapy by oral 5-fluorouracil (5-FU) significantly improved DFS and OS in patients with a TS 1+/2+ tumour (DFS: P = 0.0027, OS: P = 0.0398). These data suggest that the level of immunohistochemical TS expression is an independent prognosticator in patients with tongue SCC, and may be useful in the selection of patients who would benefit from oral 5-FU adjuvant chemotherapy.

Previous embedded DRAMs (eDRAMs) have the dual ports on the sense amplifier and wide I/O buses on memory arrays for high data rate in graphic controller chips. This causes decreased cell efficiency and increased power consumption in burst operation compared to commodity DRAM. This eDRAM macro provides the low power consumption and small die needed in portable multi media equipment with MPEG logic, such as video phone, video camera, and personal digital assistant (PDA). To incorporate 0.13 μm logic technology for low power, the power supply is reduced to 1.0 V for logic and 2.5 V for other circuitry. This paper describes realizing fast memory access even at such low voltage.

The prenatal therapy is described of a patient with vitamin B12-responsive methylmalonic acidaemia during the last 10 days of gestation with oral administration of vitamin B12 (20 mg/day) given to a mother did not normalize her urinary excretion of methylmalonic acid (MMA), which was 14.5 mmol/mol creatinine at 32 weeks of gestation. Before delivery, the mother was excreting 18.9 +/- 3.3 mmol MMA/mol creatinine (mean value at 7 days after vitamin B12 therapy), as well as at 32-37 weeks of gestation with no therapy. After birth, the level of MMA in the infant's urine was remarkably elevated (500-700 mmol/mol creatinine); the level of MMA in maternal urine decreased dramatically after delivery. Compared with two previous reports, the length of administration was not sufficient to reduce maternal MMA excretion. In future, the length of the therapy, route of administration and total dose of vitamin B12 to maintain an efficient level of vitamin B12 in an affected fetus should be considered.

A 14 year old boy was diagnosed as suffering from type 1 muscle fibre hypotrophy with internal nuclei. On histological examination of a biopsied muscle, there was selective hypotrophy of type 1 muscle fibre with internal nuclei, and focal degenerative changes were seen in a few type 1 fibres. The small type 1 fibres were arranged in small or large groups in one bundle. An EMG study of moderately weak muscles revealed low amplitude and short duration motor unit potentials as well as normal potentials and no spontaneous discharges. The H reflexes were abnormally low in amplitude comapred with the M response. The histological and electrophysiological findings suggested that the type 1 fibre involvement in the present case may have a neurogenic basis. It is likely that the clinical features of the reported cases are too variable for a single clinical entity.

Femoral arteriovenous fistula (AVF) was performed and closed after a month in the dogs.Follow up studies were carried out on blood flow, blood pressure, angiogram, diameter of blood vessel and cardio-thoracic rate (CTR).The results obtained were mainly as follows:1. Increased blood flow of femoral artery decreased considerably and blood pressure increased after closure of AVF.2. Dilated proximal femoral artery recovered during three or four weeks after closure of AVF.3. Increased CTR recovered within four weeks after closure of AVF.4. Increased collateral vessels decreased after closure of AVF.

A Japanese family with progressive spinal muscular atrophy is presented. Seven members in two generations were affected and the mode of inheritance was probably an autosomal recessive trait. A characteristic feature of this family was the presence of oculopharyngeal involvement in some of the affected members, in addition to the variable distribution of muscular atrophy among each of the affected members, such as mainly proximal or distal atrophies in the limbs. In one case the oculopharyngeal weakness appeared without limb involvement. The changes in the extremities were thought to be of neurogenic origin, and so was the progressive external ophthalmoplegia seen characteristically in these cases, although the latter was similar to ocular myopathy.