1. Neuroimaging Features of Tuberous Sclerosis Complex and Chiari Type I Malformation: A Rare Association
- Author
-
Luciano Zizzo, Francesco Perfetto, Roberta Vinci, Angelo Pio Moffa, Luca Macarini, Gianpaolo Grilli, and Leonardo P Specchiulli
- Subjects
Computed tomography ,Case Report ,tuberous sclerosis complex ,030218 nuclear medicine & medical imaging ,White matter ,03 medical and health sciences ,Tuberous sclerosis ,0302 clinical medicine ,Neuroimaging ,Subependymal nodules ,hamartomatous lesions ,Medicine ,Chiari malformation I ,magnetic resonance imaging ,Foramen magnum ,neuroimaging ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Magnetic resonance imaging ,computed tomography ,Chiari type i malformation ,medicine.disease ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,business ,Nuclear medicine ,030217 neurology & neurosurgery - Abstract
An 8-year-old girl was admitted during the night in our emergency department for an acute episode of seizures. The patient underwent computed-tomography (CT) brain scan (Toshiba ® Aquilion 64-TSX-101A/HC) and magnetic resonance imaging (MRI) brain scan (Philips® Achieva 1.5T). CT scan showed left frontal calcified nodules and calcified periventricular subependymal nodules. Subsequently, MRI evaluation revealed cortical and subcortical nodules that showed low signal with respect to the white matter on T1-weighted imaging sequences and high signal both in T2-weighted imaging sequences and in fluid-attenuated inversion recovery sequences. We also showed a herniation of cerebellar tonsils through the foramen magnum (Chiari malformation Type I [CMI]) with the associated hydrosyringomyelic cavity. Our report showed a rare association between tuberous sclerosis complex and CMI.
- Published
- 2018