Author: "Sibio, A" / Topic: business.industry - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Sibio, A"' showing total 110 results

Start Over Author "Sibio, A" Topic business.industry

110 results on '"Sibio, A"'

1. Airway and Alveoli Organoids as Valuable Research Tools in COVID-19

Author: Marna Eliana Sakalem, Miriane de Oliveira, Maria Teresa De Sibio, and Felipe Allan da Silva da Costa
Subjects: Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Biomedical Engineering, Review, medicine.disease_cause, Bioinformatics, Biomaterials, In vivo, Organoid, Humans, Medicine, Respiratory system, 3D cell models, Lung, Coronavirus, SARS-CoV-2, business.industry, respiratory disorders, COVID-19, Organoids, Pulmonary Alveoli, medicine.anatomical_structure, virions, coculture, business, Airway
Abstract: The coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, SARS-CoV-2, affects tissues from different body systems but mostly the respiratory system, and the damage evoked in the lungs may occasionally result in severe respiratory complications and eventually lead to death. Studies of human respiratory infections have been limited by the scarcity of functional models that mimic in vivo physiology and pathophysiology. In the last decades, organoid models have emerged as potential research tools due to the possibility of reproducing in vivo tissue in culture. Despite being studied for over one year, there is still no effective treatment against COVID-19, and investigations using pulmonary tissue and possible therapeutics are still very limited. Thus, human lung organoids can provide robust support to simulate SARS-CoV-2 infection and replication and aid in a better understanding of their effects in human tissue. The present review describes methodological aspects of different protocols to develop airway and alveoli organoids, which have a promising perspective to further investigate COVID-19.
Published: 2021

2. Argentina’s National Program for Control of Breast Cancer: Time 1, Patient Navigation, and Patient Cancer Education Experience

Author: Dora Valencia, Amr S. Soliman, Patricia Gallardo, Veronica Pesce, Alejandro Di Sibio, Irma N. Ramos, Jorge Gomez, and Paula Granda
Subjects: medicine.medical_specialty, Latin Americans, Control (management), Argentina, Early detection, Breast Neoplasms, Article, 03 medical and health sciences, Breast cancer, 0302 clinical medicine, Patient navigation, Cancer education, medicine, Humans, 030212 general & internal medicine, business.industry, Incidence, Mortality rate, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Cancer, Survey research, medicine.disease, Time 1, Latin America, Oncology, 030220 oncology & carcinogenesis, Family medicine, Income, Female, business, Barriers
Abstract: Argentina has the second highest mortality rate for breast cancer (BC) in South America. The age-standardized incidence of BC in Argentina is 73 per 100,000. Despite the availability of early detection services, 30% of BCs are diagnosed at advanced disease stages. The National Cancer Institute (NCI) of Argentina and the National Program for Control of Breast Cancer (NPCBC) focus on two main objectives: guaranteeing adequate and timely BC treatment and reducing BC mortality in Argentina. These objectives are addressed by maintaining three core concepts: quality control, disease monitoring, and wide coverage of available early detection and treatment services. The NPCBC is currently implementing the "Time 1 Survey Study." Time 1 is defined as the time from the first appearance of BC signs or symptoms to the first consult within the public healthcare system. This timeframe is important in Argentina because it is outside of the health timeframes and data parameters monitored by the national cancer data registry system. The Time 1 Survey study has the potential to serve as an informational tool for BC patient navigation efforts in Argentina because it can be used to identify and characterize the barriers and delays that women face during Time 1. Lessons and experiences included in this study could be translated to other Latin American and middle-income countries for developing cancer control programs that can lead to improving treatment and reducing mortality through patient navigation and cancer education efforts for the public, health professionals, and patients.
Published: 2021

3. Evaluating the multivisceral involvement on adult-onset Still’s disease to retrieve imaging-based differences in patients with and without macrophage activation syndrome: results from a single-centre observational study

Author: Alessandra Di Sibio, Onorina Berardicurti, Riccardo Monti, Antonio Barile, Piero Ruscitti, Viktoriya Pavlych, Carlo Masciocchi, Paola Cipriani, Alessandro Conforti, Ilenia Di Cola, and Federico Bruno
Subjects: Adult, medicine.medical_specialty, Adult-onset Still's disease, business.industry, Macrophage Activation Syndrome, General Medicine, Disease, Prognosis, medicine.disease, Gastroenterology, Rheumatology, medicine.anatomical_structure, Internal medicine, Macrophage activation syndrome, Ferritins, medicine, Humans, Observational study, In patient, business, Complication, Still's Disease, Adult-Onset, Lymph node, Retrospective Studies
Abstract: In this study, we aimed at describing the multivisceral involvement on adult-onset Still's disease (AOSD) to retrieve imaging-based differences in patients with and without macrophage activation syndrome (MAS). From our historical cohort, patients were assessed among those who underwent a total body CT scan. Clinical and CT scan characteristics of AOSD patients with and without MAS were compared. Out of 39 AOSD patients evaluated, 14 were complicated by MAS. These patients showed higher values of ferritin and systemic score. AOSD patients with MAS presented a higher prevalence of lung disease, hepatomegaly, splenomegaly, abdominal effusions, and lymph node enlargement than others without this complication. In addition, the presence of these manifestations significantly correlated with the systemic score, furtherly reinforcing its prognostic value. Due to the specific design of our study, our findings could be burdened by a selection bias since assessing those patients underwent a total body CT scan. Thus, these data should be prudently generalised suggesting the need of further studies to fully elucidate this issue. Our findings showed a higher prevalence of multiorgan involvement in AOSD patients with MAS, suggesting imaging-based differences, although other studies are needed to fully assess this issue. Pulmonary disease, hepatomegaly, splenomegaly, lymph node enlargement, and abdominal effusions were associated with a more aggressive subset of AOSD. Key Points •The importance of an accurate assessment AOSD multivisceral involvement is suggested since it is associated with life-threatening complications. •A higher prevalence of multiorgan involvement in AOSD patients with MAS could be recognised, than others without this complication, suggesting imaging-based differences. •AOSD multivisceral involvement may correlate with the systemic score, furtherly reinforcing its prognostic value.
Published: 2021

4. DElayed COloRectal cancer care during COVID-19 Pandemic (DECOR-19): Global perspective from an international survey

Author: Santoro, Giulio A., Grossi, Ugo, Murad-Regadas, Sthela, Nunoo-Mensah, Joseph W., Mellgren, Anders, Di Tanna, Gian Luca, Gallo, Gaetano, Tsang, Charles, Wexner, Steven D, LA TORRE, Filippo, Abary Ryan Rainiel, A, Philippines, Abdelwahab Khaled M, Egypt, Abellán Antonio M, Spain, Abraham Ned, Australia, Achkasov Sergey I, Russia, Adamina Michel, Switzerland, Adamo Vincenzo, Italy, Agapov Mikhail, Russia, Agarwal Amit, Usa, Aguado López Héctor, Spain, Aguilar Werner, Chile, AguilarMartínez María Del Mar AM, Spain, Aguilera Asuncion, Spain, Ahmed Jamil, Uk, Aiello Domenico, Italy, Akagi Tomonori, Japan, Akcakaya Adem, Turkey, Akhtar Khalid I, Pakistan, Akiba Ricardo, Brazil, Akrami Majid, Iran, Akyol Cihangir, Turkey, Alaamer Ohood H, Saudi Arabia, Alapati Kishore, India, Alasari Sami, Saudi Arabia, Albastaki Sara, Uae, Albergaria Diogo, Portugal, Alconchel Felipe, Spain, Alerta-Torre Andrea J, Philippines, Alex Ochsner, Switzerland, Alexander Herold, Germany, Alfaro Samuel, El Salvador, Ali Jehangir F, Pakistan, Aliyazicioglu Tolga, Turkey, Almgla Naser, South Africa, Alonsopoza Alfredo, Spain, Al-Radjid Jamiri, Philippines, Alselaim Nahar A, Saudi Arabia, Altaf Kiran K, Uk, Althebaity Rasha, Saudi Arabia, Altinel Yuksel, Turkey, Altiparmak Basak, Turkey, Altomare Donato F, Italy, Alvandipour Mina, Iran, Alvarez-Gallego Mario, Spain, Alyami Mohammad, Saudi Arabia, Amado Sandra, Portugal, Amato Antonio, Italy, Amodio Pietro M, Italy, Ana-Maria Mușină, Romania, Andrade Luis, Chile, Andreas Kohler, Switzerland, Angelini Giulio, Italy, Angenete Eva, Sweden, Annicchiarico Alfredo, Italy, Antelo Galarza Renan, Bolivia, Anwer Mariyah, Pakistan, Aparício David J, Portugal, Arciniega Jose A, Mexico, Arezzo Alberto, Italy, Argenio Giulio, Italy, Arenas Mara, Belgium, Arnaud Alves AA, France, Arredondo Jorge, Spain, Arslan Baha, Turkey, Arya Shobhit, Uk, Aselmann Heiko, Germany, Aumann Georg, Germany, Avanzolini Andrea, Italy, Avendano Rodolfo, Chile, Awedew Atalel F, Ethiopia, Ayantunde Abraham, Uk, Aycan Ilker, Turkey, Aytac Erman, Turkey, Azevedo Constança TM, Portugal, Ba Am, Iraq, Bader Fg, Germany, Baehrle Markus, Germany, Bagaglini Giulia, Italy, Balaban Vladimir, Russia, Balciscueta Zutoia, Spain, Balciscueta Izaskun, Spain, Baldazzi Gianandrea, Italy, Balik Emre, Turkey, Bandolon Robert, Philippines, Barberis Andrea, Italy, Barisic Goran I, Serbia, Barrera Alejandro, Chile, Barros Inês MSF, Portugal, Basaran Betul, Turkey, Basilio Pedro C, Brazil, Bech Flemming, Denmark, Behboo Roubik, Iran, Behboudi Behnam, Iran, Beitia Ivan E, Panama, Bellato Vittoria, Italy, Bellolio Felipe, Chile, Benli Sami, Turkey, Bernal Jc, Spain, Bernante Paolo, Italy, Berrospi Francisco E, Peru, Bertelson Noelle, Usa, Bevan Katharine, Uk, Bhama Anuradha, Usa, Bianco Francesco, Italy, Bievel Radulescu Raluca, Romania, Bintraiki Thamer, Saudi Arabia, Bisgin Tayfun, Turkey, Bislenghi Gabriele, Belgium, Blaslaina Juanluis, Spain, Bloom Itm, Uk, Boehm Gabriele, Germany, Bogoni Selene, Italy, Bohlooli Mehrdad, Iran, Bondurri Andrea, Italy, Boni Luigi, Italy, Bonomi Alessandro Michele, Italy, Booning Nitikun, Thailand, Boonpipattanapong Teeranut, Thailand, Bordeianou Liliana, Usa, Bossard Kerrie, Usa, Botelho Maria, Portugal, Boto Carlos, Portugal, Bottini Corrado, Italy, Bouchagier Konstantinos, Greece, Boutall Adam, South Africa, Bowers Dan, Usa, Bozbiyik Osman, Turkey, Brambilla Eduardo, Brazil, Brisinda Giuseppe, Italy, Brizzi Maria Pia, Italy, Brizzolari Marco, Italy, Brusciano Luigi, Italy, Bucci Luigi, Italy, Buchwald Pam, Sweden, Bugra Dursun, Turkey, Bui Andrew, Australia, Buldanlı Mehmet Zeki, Turkey, Bulut Orhan, Denmark, Cagigas Fernandez Carmen, Spain, Cai Yuankun, China, Calcerrada Alises Enrique, Spain, Caldes Pedro, Portugal, Calussi Marco, Italy, Calvo Espino Pablo, Spain, Campanelli Michela, Italy, Campbell Ken, Uk, Campennì Paola, Italy, Canda Arasemre, Turkey, Capolupo Gabriella T, Italy, Caravana Jorge, Portugal, Carballo Federico HE, Argentina, Carbone Fabio, Italy, Carcamo Leonardo C, Chile, Cardoso Paulo, Portugal, Cariati Maria, Italy, Caricato Marco, Italy, Carmona Maria, Spain, Carpelan Holmstrom Monika, Finland, Carrié Augusto J, Argentina, Carrino Francesco, Italy, Cartucho Daniel DF, Portugal, Carvalho Marcia, Portugal, Carvas João M, Portugal, Casagranda Biagio, Italy, Casimiro Carlos, Portugal, Castro Anyely, Dominican Republic, Catiwala-An Michael T, Philippines, Caushaj Philip F, Usa, Cavallo Debora, Italy, Cedermas Mariela, Argentina, Celayir Fevzi, Turkey, Celentano Valerio, Uk, Cengiz Fevzi, Turkey, Chaisomboon Nopdanai, Thailand, Chenghua Luo, China, Cherepenin Mikhail, Russia, Chessa Antonella, Italy, Chierici Andrea, France, Chok Aikyong, Singapore, Chouliaras Christos, Greece, Chowchankit Irin, Thailand, Christou Niki, France, Chun Hokyung, South Korea, Cillara Nicola, Italy, Cinza Margarida, Portugal, Cione Gianpiero, Italy, Cipe Gokhan, Turkey, Ciprian Duta, Romania, Cirocco William, Usa, Citgez Bulent, Turkey, Clark Jill E, Usa, Clementi Ilaria IC, Italy, Clerc Daniel, Switzerland, Clermonts Journal Pre-proof 39 Stefan HEM, Netherlands, Cobellis Luigi, Italy, Colak Tahsin, Turkey, Colao Garcia Laura, Spain, Colombo Francesco, Italy, Comba Andrea, Italy, Coret Franco Alba CFA, Spain, Correa Bonito Alba, Spain, Cosman Bard, Usa, Costa Susana GS, Portugal, Costa Marta RP, Portugal, Costa Pereira Joaquim, Portugal, Cózar Lozano Coral, Spain, Cravero Francesca, Italy, Creavin Ben, Ireland, Cross Katie LR, Uk, Cruz Arturo, Spain, Cui Junhui, China, Cunha Miguel F, Portugal, Curado Antonio, Portugal, D'Ugo Stefano, Italy, Dajti Irida, Albania, Dalessandro Antonio, France, Dal Monte Giorgio, Italy, Danelli Piergiorgio, Italy, Daniels Ian R, Uk, Dar Asif M, India, Davies Richard J, Uk, De Andrés Beatriz, Spain, De Angelis Marsilio, Italy, De Falco Nadia, Italy, De Luca Maurizio, Italy, De Luca Raffaele, Italy, De Nardi Paola, Italy, De Rosa Michele, Italy, De Silva Kaluthanthiri Patabanadi VR, Sri Lanka, De Simone Veronica, Italy, De Wilt Johannes HW, Netherlands, De-León-Rendón Jorge Luis, Mexico, Dean Phillip, Usa, Deangelis Nicola, France, Dedemadi Georgia, Greece, Delgadillo Xavier, Switzerland, Delgadillo Edgar, Switzerland, D’Elia Antonio, Italy, Delibegovic Samir, Bosnia and Herzegovina, Delis S, Greece, Della Porta Massimiliano, Italy, Del Rio Paolo, Italy, De Marano Gaetano, Italy, Demey Karel, Belgium, Demirli Atıcı Semra, Turkey, Denoya Paula I, Usa, Derebey Murat, Turkey, De Santis Mariangela, France, Devezas Vítor BS, Portugal, Dhaif Ali, Bahrain, Diaconescu Bogdan, Romania, Di Candido Francesca, Italy, Die Javier, Spain, Dieguez Beatriz, Spain, Dieter Hahnloser, Switzerland, Diez Alonso Manuel, Spain, Dimaren Ishmael, Philippines, Disimone Massimo, Italy, Doerner Johannes, Germany, Domingos Hugo VG, Portugal, Dominguez Rubén RD, Paraguay, Dorenbusch Michael, Usa, Doulias Triantafyllos A, Uk, Duff Sarah, Uk, Dulskas Audrius, Lithuania, Dunn Gary, Usa, Duque-Mallén Victoria, Spain, Dusek Tomas, Czech Republic, Dusitanond Navara, Thailand, Dzulkarnaen Zakaria Andee, Malaysia, Dworkin Michael, United Kingdom, Dybau Aleh, Belarus, Dziakova Jana, Spain, Dziki Lukasz, Poland, Dziki Adam, Poland, Efetov Sergey K, Russia, Eisa Mohamed, Egypt, Eisenstat Ted, Usa, El Sorogy Mohamed, Egypt, El-Hussuna Alaa, Denmark, Elfeki Hossam, Egypt, Elhussuna Alaa, Denmark, Eliasrabelo Fernanda, Brazil, Ellis Tyler, Usa, Elzalabany Tamer, Egypt, Emile Sameh H, Egypt, Emiroglu Mustafa, Turkey, Emmanuel Odet, France, Enomoto Masanobu, Japan, Epifani Angelo Gabriele, Italy, Erenler Ilknur, Turkey, Erkan Arman, Usa, Erol Timuçin, Turkey, Erturk Suphan, Turkey, Escalante Ricardo, Venezuela, Escartin Jorg, Spain, Escrevente Ricardo, Portugal, Espin-Basany Eloy, Spain, Estaire-Gomez Mercedes, Spain, Falaschi Federica, Italy, Falken Ylva, Sweden, Fantini Corrado, Italy, Fantozzi Mauricio, Argentina, Farid Asim, Usa, Farina Pablo, Argentina, Farmer Russ, Usa, Farmer Martin, Uk, Faul Eleanor M, Ireland, Favara Andrea, Italy, Febra Pedro, Portugal, Fenner Lyra Junior Humberto, Brazil, Fermani Claudio, Argentina, Fernandes Fábio FN, Portugal, Fernandes Miguel, Portugal, Ferracci Federica, Italy, Ferrara Francesco, Italy, Ferrari Giovanni, Italy, Ferrario Luca, Italy, Ferreira Rita, Portugal, Ferreira Carlos, Portugal, Ferris Jeff, Usa, Ferronetti Antonio, Italy, Fialho Guilherme L, Portugal, Fichera Alessandro, Usa, Figueiredo Odete, Portugal, Filipe Vieira Pedro JG, Portugal, Fiore Felicia, Italy, Folliero Cristina, Italy, Folstad Torbjorn, Norway, Forerotorres Alexander, Spain, Forgan Timothy R, South Africa, Franceschilli Marzia, Italy, Frizelle Frank, New Zealand, Froehner Junior Ilario, Brazil, Frois Miguel, Portugal, Frontali Alice, France, Fu Chuangang, China, Fulginiti Serena, Italy, Galiffa Giampaolo, Italy, Gallagher Hugh J, Uk, Gallardo Cristian, Chile, Galleano Raffaele, Italy, Gama Barbara, Portugal, Garcia Conde Maria, Spain, Garcia Granero Alvaro, Spain, Garcia Esther, Spain, García Sánchez Felipe, Spain, Garcia Septiem Javier, Spain, Garcia Walter, Argentina, Garcia-Urena Miguel Angel, Spain, Garmanova Tatiana N, Russia, Garofalo Thomas, Usa, Garoufalia Zoe, Greece, Garulli Gianluca, Italy, Gatti Matteo, Italy, Gecim Ethem, Turkey, Gellona Jose, Chile, Gercek Yuksel, Uk, Ghignone Federico, Italy, Gianchandani Moorjani Rajesh, Spain, Gianfrancisco James A, Usa, Giani Iacopo, Italy, Gibert Juan, Spain, Gilles Manceau, France, Gilmore Andrew, Australia, Gilsanz Carlos, Spain, Gilshtein Hayim, Usa, Girgin Behic, Turkey, Giria Joao, Portugal, Giuffrida Maria Carmela, Italy, Giuliani Antonio, Italy, Goi Gloria, Italy, Golovina Anastasiya, Russia, Gomez Rosado Juan Carlos, Spain, González Enrique, Spain, Granada Nemesio, Philippines, Grimme Frederike, Netherlands, Grobler Stephen, South Africa, Guaitoli Eleonora, Italy, Guerci Claudio, Italy, Guerra Daniel, Mexico, Guerreiro José MM, Portugal, Guido Jutten, Belgium, Gulcu Baris, Turkey, Gunay Emre, Turkey, Gundes Ebubekir, Turkey, Gurbuz Bulent, Turkey, Gurjar Shashank, Uk, Hainsworth Alison J, Uk, Hall Nigel, Uk, Hamed Hosam H, Egypt, Hammer Clare, Uk, Hannon Rob, Ireland, Harmston Christopher, New Zealand, Harran Nadine, South Africa, Hartendorp Paul, Usa, Hassan Iyad, Uae, Hassan Imran, Usa, Hawkins Alexander T, Usa, Hayssen Theresa, Usa, Hendren Samantha, Usa, Hernandez Garcia Miguel, Spain, Hershman Michael, Journal Pre-proof 40 UK, Hild Stefanie, Germany, Hilton Joanna, Uk, Hiranyakas Art, Thailand, Ho Ming, Australia, Hollington Paul, Australia, Holubar Stefan, Usa, Hompes Roel, Netherlands, Houcine Maghrebi, Tunisia, Hovsepyan Vardges, Armenia, Hul Rene, Netherlands, Hunt Louise E, Uk, Hyder Zargham, Uk, Ibrahim Aini F, Malaysia, Iglesias Gustavo, Brazil, Iesalnieks Igors, Germany, Ilkanich Andrei, Russia, Imanova Nargiz, Azerbaijan, Isik Arda, Turkey, Jayathilaka Buddika, Uk, Jimenez Virginia, Spain, Jimenez-Gomez Luis Miguel, Spain, Jitmungngan Romyen, Thailand, Joelsson Magnus, Sweden, Joshi Heman, Uk, Juloski Jovan T, Serbia, Juwid Abdallah E, Libya, Kanjanasilp Prapon, Thailand, Kannappa Lava, Uk, Kanno Danilo, Brazil, Kaplan Esin, Turkey, Kara Yasin, Turkey, Kartal Abdulcabbar, Turkey, Kawamura Junichiro, Japan, Kaya Tayfun, Turkey, Kazemi Nava Andrea, Italy, Kazachenko Ekaterina A, Russia, Kelkar Ashish, Uk, Kelly Michael E, Ireland, Keramati Mohammad Reza, Iran, Kerawala Asad, Pakistan, Khalil Mohammad I, Bangladesh, Khan Jim S, Uk, Khan Rbn, Uk, Khitaryan Alexander, Russia, Kinjo Tatsuya, Japan, Kirilova Tanya N, Bulgaria, Kirmizi Yasemin, Turkey, Klaristenfeld Daniel, Usa, Knapp Jens, Norway, Koc Mehmet A, Turkey, Kocián Petr, Czechia, Konishi Tsuyoshi, Japan, Konstantoudakis Georgios, Cyprus, Konsten Joop, Netherlands, Kontovounisios Christos, Uk, Korkmaztoker Melike, Turkey, Kørner, Hartwig, Norway, Krdzic Igor, D, Serbia, Krivokapic Zoran, Serbia, Kumar Sanjeev, India, Kumar Sandip, Malaysia, Kushtrim Shala, Germany, Kynaston James, Uk, Langmayr Johannes, Austria, La Torre Marco, Italy, La Torre Filippo, Italy, Labalde Maria, Spain, Lagopoulos Vasileios, Greece, Lal Roshan, Uk, Landaluce- Olavarria Aitor, Spain, Langone Antonio, Italy, Lapolla Pierfrancesco, Italy, Larach Sergio, Usa, Larach, Andres, Chile, Larsson, Peranders, Sweden, Lasala Alfred, Philippines, Lauretta Andrea, Italy, Leao Pedro, Portugal, Lee Pamela C, Usa, Lee Suk-Hwan, South Korea, Lee Wooyong, South Korea, Lefevre Jeremie H, France, Leite Julio, Portugal, Lemaire Julien, Belgium, Lemma Maria, Italy, Lemme Gustavo Nestor, Argentina, Lenna Giovanni, Italy, Leo Cosimo Alex, Uk, Leventoglu Sezai, Turkey, Licardie Eugenio, Spain, Lienert Mark, Germany, Lima Sergio, Brazil, Limbert Manuel CSB, Portugal, Lisi Giorgio, Italy, Litta Francesco, Italy, Littaua Dennis, Philippines, Liu Fanlong, China, Liyanage Chris, New Zealand, Llovera Antony, Cuba, Lo Oswens, China, Lo Dico Rea, France, Lobascio Pierluigi, Italy, Lohsiriwat Varut, Thailand, Lombana Luis, Colombia, Lopez Marc, Philippines, Lopez Jose, Mexico, Lopez Francisco, Chile, Lorber Julie, Usa, Losada Manuel, Spain, Lowenfeld Lea, Usa, Lucci Enrico, Italy, Luglio Gaetano, Italy, Lynch Craig, Australia, Luqman, Pakistan, Machairas Nikolaos, Uk, Maciel João MRP, Portugal, Madbouly Khaled, Egypt, Madhoun, Nisreen, Usa, Maffioli, Anna, Italy, Magbojos Christian Raymond S, Philippines, Magistro Carmelo CM, Italy, Magrino Thomas, Usa, Makhoul Rami, Usa, Mallmann Karen DP, Brazil, Manatakis Dimitrios K, Greece, Mancini Stefano, Italy, Manfredelli Simone, France, Mangione John, Usa, Manso Antonio, Portugal, Marakutsa Eugen V, Moldova, Marano Alessandra, Italy, Marchesi Federico, Italy, Marchiori Mauro, Brazil, Marfan Michael, Australia, Marianelli Raphael, Brazil, Mariani Nicolò M, Italy, Marimuthu Kalimuthu, Uk, Marinello Franco, Spain, Marinis Athanasios, Greece, Marino Marco V, Italy, Markides Georgios, Cyprus, Marquez Lucila, Spain, Marra Angelo A, Italy, Martín Navarro Fabian, Mexico, Martin-Martin Gonzalo P, Spain, Martinez Javier, Spain, Martinez-Iglesias Marta A, Uk, Martins Ruben AFP, Portugal, Martins Ana RG, Portugal, Mascali Davide DM, Italy, Massucco Paolo, Italy, Matas Fernando, Spain, Mathew Alexander, Usa, Matzel Klaus E, Germany, Maun Dipen, Usa, Maurus Christine F, Switzerland, McCormick Jim, Usa, McIntyre Robert, Uk, McKinley Aileen, Uk, McLemore Lisa, Usa, McNeil Jennifer, Usa, McNevin Shane, Usa, Medich David, Usa, Medina Cesar, Mexico, Medina Quintana Rita E, Spain, Melo Ingrid, Paraguay, Melstrom Kurt A, Usa, Mendoza-Moreno Fernando, Spain, Menna Maria Paola, Italy, Mentz Ricardo, Argentina, Merlini David A, Italy, Mihmanli Mehmet, Turkey, Mike Spencer, Usa, Millan Monica, Spain, Miller Jerad, Usa, Milone Marco, Italy, Minahi Ilyas, Uk, Minaya-Bravo Ana María, Spain, Mingoli Andrea, Italy, Minicozzi Annamaria, Uk, Miranda Pedro, Portugal, Miro Antonio, Italy, Miskovic Danilo, Uk, Mistrangelo Massimiliano, Italy, Mitra Rajarshi, Uae, Mittal Rohin, India, Mladenovikj Dragoslav P, North Macedonia, Moctezuma Velázquez Paulina, Mexico, Mohamed Kamil Nil Amri, Malaysia, Mohammed Mohammed MH, Egypt, Mohsen Yasser MA, Uk, Monami Benoit N, Belgium, Monroe Justin, Usa, Monroy Hermogenes DJ, Philippines, Montori Giulia, Italy, Montuori Mauro, Italy, Mora-Guzmán Ismael, Spain, Moraes Ana, Brazil, Morales Carlos, Usa, Morelli Luca, Italy, Moreno Almudena, Spain, Moretto Gianluigi, Italy, Morici Riccardo, Italy, Morini Andrea, Italy, Moro-Valdezate David, Spain, Moroni Eliana, Italy, Morton Dion, Uk, Moura Catarina, Portugal, Moysidis Moysis M, Greece, Mozo Ana S, Spain, Nacion Aeris Jane D, Philippines, Nada Mohamed, Journal Pre-proof 41 Egypt, Nagasaki Toshiya, Japan, Nakamoto Yoshihiko, Japan, Neary Peter, Ireland, Negoi Ionut, Romania, Neijenhuis Peter A, Niger, Ng Simon SM, China, Niazi Samiullah, Pakistan, Nikoupour Hamed, Iran, Nogueiro Jorge PM, Portugal, Noguera Jose, Spain, Nova Carlos, Portugal, Nunes Amadeu, Portugal, O'Riordain Micheal G, Ireland, Oke Olatunbosun A, Nigeria, Okkabaz Nuri, Turkey, Oliva Cristiano, Italy, Oliveira Olga, Portugal, Oliveira Manuel, Portugal, Oliveira Antonio, Portugal, Oliveira Lucia CC, Brazil, Olivier James B, Uk, Olivier Pittet, Switzerland, Omejc Mirko, Slovenia, Ong Loreto B, Philippines, Ong David, Malaysia, Onglao Mark, Philippines, Onody Peter, Hungary, Orefice Raffaele, Italy, Ortega David, Peru, Ozben Volkan, Turkey, Ozcan Onder, Turkey, Ozturk Ersin, Turkey, Pacheco Andre, Portugal, Paci Marco, France, Paczosa Marcin, Poland, Padmanabhan Anantha, Usa, Pai Ajit, India, Palmer Gabriella, Sweden, Pandey Diwakar, India, Panis Yves, France, Pantel, Haddon, Paonariang Krisada, Thailand, Papa Mario V, Italy, Papadopoulos Aristeidis, Greece, Papagni Vincenzo, Italy, Papp Andras, Sweden, Parello Angelo, Italy, Parente Alessandro, Uk, Parra Pedro, Spain, PascualMigueláñez Isabel, Spain, Pata Francesco, Italy, Patel Nikhil, Usa, Patel Reeya, Uk, Pattyn Paul RL, Belgium, Paul Bikram, Usa, Pavanello Maurizio, Italy, Pedro Luis E, Argentina, Pellino Gianluca, Spain, Peltrini Roberto, Italy, Peña Ros Emilio, Spain, Pennacchi Luca UC, Italy, Pereira André, A Portugal, Pereira Bela, Portugal, Perez Guillermo, Ecuador, Perez Horacio, Portugal, Perez Natalia, Spain, Perez Flecha Marina, Spain, Perinotti Roberto, Italy, Pernazza Graziano, Italy, Perra Teresa, Italy, Pertile Davide, Italy, Pessia Beatrice, Italy, Pessoa Joana, Brazil, Petagna Lorenzo, Italy, Peters Walter, Usa, Petit Mindy, Usa, Petracca Gabriele Luciano, Italy, Pezzolla Francesco, Italy, Philp Matthew, Usa, Pianim Nana, Usa, Picciariello Arcangelo, Italy, Piccinini Pablo E, Argentina, Piccinni Giuseppe, Italy, Piccolo Davide, Italy, Pigalarga, Rodolfo, Pikarsky Alon J, Israel, Pimentel Alice, Portugal, Pinchot Scott, Usa, Pinotti Enrico, Italy, Pinto Diogo, Portugal, Pirozzi Felice, Italy, Plastiras Aris, Greece, Platto Marco, Italy, Plerhoples Tim, Usa, Podda Mauro, Italy, Poggi Luis, Peru, Polastri Roberto, Italy, Porcu Alberto, Italy, Porter Michael, Usa, Poskus Eligijus, Lithuania, Potolicchio Analia I, Argentina, Poylin Vitaliy, Usa, Pozzo Mauro, Italy, Pramateftakis Manos, Greece, Pravosudov Igor V, Russia, Praxedes Vanessa P, Portugal, Primoromaguera Vicent, Spain, Progno Valerio C, Italy, Proud David M, Australia, Pucciarelli Salvatore, Italy, Qadir Abdul, Uk, Qayoom Hina, Pakistan, Quindos Patricia, Spain, Quintanilha Rui, Portugal, Quinteros Francisco A, Usa, Qureshi Nafees, Uk, Rachadell Juan J, Portugal, Ralf Schmidt, Germany, Raman Shankar, Usa, Ramos Diego, Spain, Ramos Jose, Portugal, Ramwell, Andrew, Randazzo, Valentina, Rattanarpichart Patsaporn, Thailand, Ratto Carlo, Italy, Rautio Tero, Finland, Raviolo Carla, Italy, Read Thomas, Usa, Real Joao, Portugal, Rega Daniela, Italy, Regadas Francisco, Brazil, Regenbogen Scott, Usa, Reia Marta, Portugal, Reina Angel, Spain, Rems Miran, Slovenia, Rencuzogullari Ahmet, Turkey, Renwick Andrew A, Uk, Reyes Juan C, Colombia, Reyes Jeryl Anne Silvia R, Philippines, Ribeiro Jr Ulysses, Brazil, Ridzuan Farouk, Singapore, Ripetti Valter, Italy, Ripoll Cristina, Mexico, Ripollés-Melchor Javier, Spain, Rizal Rizal, Indonesia, Rizk Mariam, Uk, Rizvi Irfan, Usa, Robinson Jonathan, Uk, Rodimov Sergei, Russia, Rodrigues João VL, Brazil, Rodriguez Javier, Mexico, Rodriguez Cristian, Argentina, Rodriguez Homero, Panama, Rodriguez Garcia Jaime, Mexico, Roig Jose, Spain, Rojanasakul Arun, Thailand, Rojas Julio, Chile, Romanelli Elena, France, Rosa Fausto, Italy, Rosato Guillermo, Argentina, Rosenberg Robert, Switzerland, Rosete Manuel, Portugal, Roslani April C, Malaysia, Rottoli Matteo, Italy, Roxas Manuel Francisco Roxas T, Philippines, Roxburgh Campbell S, Uk, Ruan Joseph, Usa, Rubbini Michele M, Italy, Rubio Eduardo, Spain, Ruddy Theresa, Usa, Rueda Camilo, Spain, Ruiztovar Jaime, Spain, Rusconi Andrea, Italy, Rutegård Martin, Sweden, Sá Milene RRM, Portugal, Saad Luiz Henrique Cury, Brazil, Sadien Iannish D, Uk, Sadowski Brian M, Usa, Saeed Mirza Faraz, Bahrain, Safiyeva Aynur K, Azerbaijan, Sagap Ismail, Malaysia, Sahnan Kapil, Uk, Sairafi Rami, Saudi Arabia, Saklami Avanish P, India, Salgado-Nesme Noel NSN, Mexico, Salman Nevriye, Turkey, Samalavicius Narimantas E, Lithuania, Sambucci Daniele, Italy, Sanchez Noel, Usa, Sanchez Robles Juan Carlos, Mexico, Sanmiguel Carlos, Spain, Santacruz Eduardo, Paraguay, Santoni Simone, Italy, Santos Pedro MD, Portugal, Santos Brian U, Argentina, Santos Carlos, Portugal, Sapienza Paolo, Italy, Saracoglu Ayten, Turkey, Saracoglu Kemal T, Turkey, Sardinas Carlos, Venezuela, Sari Ramazan, Turkey, Sarma Diwakar, Uk, Sartori Alberto A, Italy, Sasia Diego, Italy, Sbaih Mohammed H, Saudi Arabia, Scabini Stefano, Italy, Scaringi Stefano, Italy, Scheinin Tom M, Finland, Schiavo Marcello, Italy, Schizas Alexis, Uk, Sciaudone Guido, Italy, Scognamillo Fabrizio, Italy, Scott Kelley, Usa, Scow Jeffrey S, Usa, Sechi Raffaele, Italy, Seehra Harkiran, Uk, Segering Joerg, Germany, Selcuk Mehtap, Turkey, Journal Pre-proof 42 Selemane Carlos, Mozambique, Seltman Ann, Usa, Selvaggi Francesco, Italy, Sensi Bruno, Italy, SeowChoen Francis, Singapore, Sernagiotto Carlo, Italy, Serralta De Colsa Daniel, Spain, Serrano González Javier, Spain, Sert Ismail, Turkey, Serventi Alberto, Italy, Sforza Sergio, Italy, Shabbir Jamshed, Uk, Shabeeb Fadel, Uae, Shafik Ali, Egypt, Shalaby Mostafa, Egypt, Shanker Bethann, Usa, Shanmugam Venkatesh, Uk, Shariff Umar, Uk, Shehta Ahmed, Egypt, Shelton Andrew, Usa, Shintaro Akamoto, Japan, Shlyk Daria, Russia, Shukla Amit, Uk, Sibio Simone, Italy, Sietze Koopal, Netherlands, Sigurdardottir Johanna, Sweden, Silva Jorge, Mexico, Silva Anaisa, Portugal, Simianu Val, Usa, Singh Baljit, Uk, Siragusa Leandro, Italy, Sirikurnpiboon Siripong, Thailand, Sivrikoz Emre, Turkey, Sizonenko Nikolay, Russia, Slavchev Mihail T, Bulgaria, Sniuolis Pranas, Lithuania, Soares Duarte, Qatar, Sojar Valentin, Slovenia, Sokmen Selman, Turkey, Sokol Thomas, Usa, Soldatov Denis, Russia, Soncini Stefania, Italy, Sordo Ricardo, Mexico, Sosa María V, Spain, Sousa Xavier, Portugal, Sozutek Alper, Turkey, Spiezio Giovanni, Italy, Spinelli Antonino, Italy, Stahl Etienne, Mexico, Stanojevic Goran Z, Serbia, Steckel Brian, Usa, Stefan Neagu, Romania, Stefanescu Victor, Romania, Steinhagen Randolph, Usa, Stella Marco, Italy, Stephensen Bree D, Australia, Stevenson Andrew RL, Australia, Stitzenberg Karyn, Usa, Strombom Paul, Usa, Sturiale Alessandro, Italy, Suhail Anjum, Pakistan, Sungurtekin Ugur, Turkey, Sutton Jeffrey M, Usa, Suwannakij Chanchai, Thailand, Szczepkowski Marek, Poland, Sztipits Tamas, Hungary, Takashi Akiyoshi, Japan, Takkenberg Marijn, Netherlands, Tallon-Aguilar Luis, Spain, Tam Michael, Usa, Tamburini Andrea M, Italy, Tamini Nicolò, Italy, Tammaro Pasquale, Italy, Tan Kerkan, Singapore, Tan Teerasan, Thailand, Tanal Mert, Turkey, Tanda Cinzia, Italy, Tang Jinghua, China, Tapiolas Ingrid, Uk, Täreby Magnus, Sweden, Tariverdiev Andrey, Russia, Tayar Serkan, Turkey, Tejedor Patricia, Spain, Terrosu Giovanni, Italy, Testa Alessandro, Italy, Tewari Shirish, Uk, Thabet Waleed, Egypt, Thakur Sukesh, India, Thomas Ehmann, Germany, Thomas Kuruc, Germany, Tiesi Vincenzo, Italy, Tin Moemoetin, Myanmar, Tita Agustin C, Argentina, Titu Liviu V, Uk, Tkachenko Fedot, Ukraine, Tonello Paolo, Italy, Tooley Richard, Usa, Torres Juan, Spain, Troci Albert, Italy, Trompetto Mario, Italy, Troncoso Pereira Paula, Spain, Tropeano Francesca Paola FP, Italy, Trostchansky Ivan, Uruguay, Tsujinaka Shingo, Japan, Tufo Andrea, Italy, Tulina Inna, Russia, Turati Luca, Italy, Turchina Catalin, Sweden, Turina Matthias, Switzerland, Tutino Roberta, Italy, Tyler Km, Usa, Uemura Mamoru, Japan, Unal Ayse G, Turkey, Uraiqat Ahmad, Jordan, Uribe Sebastián, Chile, V Duke, Usa, Vailati Bruna, Brazil, Vaingurt Mariano, Argentina, Valente Michael, Usa, Van Dellen Jonathan, Uk, Van Ramshorst Gabrielle H, Belgium, Vannelli Alberto, Italy, Vanriel W, Belgium, Varabei Aliaksandr, Belarus, Varcada Massimo, Uk, Varela Cristopher L, Venezuela, Varma Madhulika G, Usa, Vasapollo Leoluca F, Italy, Venn Mary L, Uk, Vercillo Kristin, Usa, Vergara-Fernandez Omar, Mexico, Veronesi Paolo, Italy, Vicente Aline, Brazil, Victor Tomulescu, Romania, Vieiradesousa Paulo, Portugal, Vignali Andrea, Italy, Vigorita Vincenzo, Spain, Vilchis Jose, Mexico, Villaverde Kathia, Peru, Vindevoghel Koen, Belgium, Violante Tommaso, Italy, Vitoopinyoparb Kasidin, Thailand, Voutsarakis Athanasios, Uk, Wainstein Ricardo, Argentina, Wakefield Simon, Uk, Wallon Conny, Sweden, Wang Yongbing, China, Wang Xiaodong, China, Wang Xiaofeng, China, Warden Claire, South Africa, Wei Rockson, China, Wheeler Matthew, Usa, Willem Bemelman, Netherlands, Wilson Matthew, Usa, Winter Des C, Ireland, Wongwiwatseree Yongsun, Thailand, Woon Kyung Jeong, South Korea, Wright Danette B, Australia, Wu Jiong, China, Wuraola Funmilola O, Nigeria, Xenaki Sofia A, Greece, Xiaohua Jiang, China, Xiaoqiang Jia, China, Xue Yahong, China, Xynos Evangelos, Greece, Yamada Kazunosuke, Japan, Yanar Hakan, Turkey, Yang Bolin, China, Yanishev Alexey, Russia, Yildirim Ali C, Turkey, Yildiz Ufukmete, Turkey, Yildiz Alp, Turkey, Yilmaz Mehmet, Turkey, Younis Muhammad Umar MUY, Uae, Yousef Zeyad, Saudi Arabia, Yu Dongsheng, China, Zalucki James, Usa, Zaman Ahamaduz, Bangladesh, Zamora Aída T, Spain, Zampitis Nikolaos, Cyprus, Zanus Giacomo, Italy, Zapata Gonzalo H, Argentina, Zelic Marko, Croatia, Zenger Serkan, Turkey, Zheng Jianyong, China, Zigiotto Daniele, Italy, Zmora Oded, Israel, Zoikas Athanasios, Greece, Zorcolo Luigi, Italy, Zucchella Martino, Italy, Zuhdy, Mohammad, Santoro G.A., Grossi U., Murad-Regadas S., Nunoo-Mensah J.W., Mellgren A., Di Tanna G.L., Gallo G., Tsang C., Rottoli M., and Wexner S.D.
Subjects: Male, medicine.medical_specialty, Delayed Diagnosis, Internationality, Colorectal cancer, colorectal surgery - COVID-19 - delay - treatment - outcomes, MEDLINE, colorectal cancer, 030230 surgery, medicine.disease_cause, Article, Time-to-Treatment, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Pandemic, medicine, Humans, Practice Patterns, Physicians', Elective surgery, Personal protective equipment, SARS-CoV-2, COVID-19, delayed surgery, Coronavirus, Infection Control, business.industry, Outbreak, medicine.disease, 030220 oncology & carcinogenesis, Preparedness, Emergency medicine, Female, Surgery, Colorectal Neoplasms, business, Colorectal Surgery
Abstract: Background The widespread nature of coronavirus disease 2019 (COVID-19) has been unprecedented. We sought to analyze its global impact with a survey on colorectal cancer (CRC) care during the pandemic. Methods The impact of COVID-19 on preoperative assessment, elective surgery, and postoperative management of CRC patients was explored by a 35-item survey, which was distributed worldwide to members of surgical societies with an interest in CRC care. Respondents were divided into two comparator groups: 1) ‘delay’ group: CRC care affected by the pandemic; 2) ‘no delay’ group: unaltered CRC practice. Results A total of 1,051 respondents from 84 countries completed the survey. No substantial differences in demographics were found between the ‘delay’ (745, 70.9%) and ‘no delay’ (306, 29.1%) groups. Suspension of multidisciplinary team meetings, staff members quarantined or relocated to COVID-19 units, units fully dedicated to COVID-19 care, personal protective equipment not readily available were factors significantly associated to delays in endoscopy, radiology, surgery, histopathology and prolonged chemoradiation therapy-to-surgery intervals. In the ‘delay’ group, 48.9% of respondents reported a change in the initial surgical plan and 26.3% reported a shift from elective to urgent operations. Recovery of CRC care was associated with the status of the outbreak. Practicing in COVID-free units, no change in operative slots and staff members not relocated to COVID-19 units were statistically associated with unaltered CRC care in the ‘no delay’ group, while the geographical distribution was not. Conclusions Global changes in diagnostic and therapeutic CRC practices were evident. Changes were associated with differences in health-care delivery systems, hospital’s preparedness, resources availability, and local COVID-19 prevalence rather than geographical factors. Strategic planning is required to optimize CRC care., Global changes in both diagnostic and therapeutic practices in colorectal cancer care were evident in this survey conducted to analyze the impact of COVID-19 outbreak. The importance of this finding is that changes were associated with differences in health care delivery systems, hospital’s preparedness, resources availability, and local COVID-19 prevalence rather than geographical variations.
Published: 2021

5. MRI only in a patient with prostate cancer with bilateral metal hip prostheses: case study

Author: Mauro Palazzi, Mohammed Abujami, Alberto Torresin, Chiara Carsana, Roberto Giuseppe Pellegrini, Angelo Filippo Monti, Domenico Lizio, S. Nici, M. Felisi, Maria Brambilla, C. Carbonini, D. Sibio, Stefano Riga, Carmelina Potente, Angelo Vanzulli, and Barbara Bortolato
Subjects: Male, Organs at Risk, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Heavy Ion Radiotherapy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Image Processing, Computer-Assisted, medicine, Humans, In patient, General hospital, Aged, medicine.diagnostic_test, business.industry, Radiotherapy Planning, Computer-Assisted, Prostatic Neoplasms, Magnetic resonance imaging, General Medicine, medicine.disease, Magnetic Resonance Imaging, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, Metal-on-Metal Joint Prostheses, Hip Prosthesis, Radiology, Artifacts, business, Radiotherapy, Image-Guided
Abstract: Objective: To outline a practical method of performing prostate cancer radiotherapy in patients with bilateral metal hip prostheses with the standard resources available in a modern general hospital. The proposed workflow is based exclusively on magnetic resonance imaging (MRI) to avoid computed tomography (CT) artifacts. Case description: This study concerns a 73-year-old man with bilateral hip prostheses with an elevated risk prostate cancer. Magnetic resonance images with assigned electron densities were used for planning purposes, generating a synthetic CT (sCT). Imaging acquisition was performed with an optimized Dixon sequence on a 1.5T MRI scanner. The images were contoured by autosegmentation software, based on an MRI database of 20 patients. The sCT was generated assigning averaged electron densities to each contour. Two volumetric modulated arc therapy plans, a complete arc and a partial one, where the beam entrances through the prostheses were avoided for about 50° on both sides, were compared. The feasibility of matching daily cone beam CT (CBCT) with MRI reference images was also tested by visual evaluations of different radiation oncologists. Conclusions: The use of magnetic resonance images improved accuracy in targets and organs at risk (OARs) contouring. The complete arc plan was chosen because of 10% lower mean and maximum doses to prostheses with the same planning target volume coverage and OAR sparing. The image quality of the match between performed CBCTs and MRI was considered acceptable. The proposed method seems promising to improve radiotherapy treatments for this complex category of patients.
Published: 2021

6. The Role of Active Inflammation and Surgical Therapy in Crohn’s Disease Recurrence

Author: L. Petagna, Andrea Divizia, Vittoria Bellato, A. Antonelli, Giuseppe S. Sica, Leandro Siragusa, Simone Sibio, S. Ingallinella, Michela Campanelli, Bruno Sensi, Marzia Franceschilli, and C. Arcudi
Subjects: medicine.medical_specialty, medicine.medical_treatment, MEDLINE, crohn's disease, inflammation, surgical therapy, recurrence, Inflammation, RC799-869, Review Article, Disease, Cochrane Library, Inflammatory bowel disease, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Immune system, Internal medicine, medicine, Crohn's disease, Hepatology, business.industry, Bowel resection, Diseases of the digestive system. Gastroenterology, medicine.disease, digestive system diseases, Settore MED/18, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract: An altered balance between effector and regulatory factors is supposed to sustain the tissue-damaging immune response in inflammatory bowel disease (IBD). Several studies demonstrate that severe active inflammation is a strong predictor for surgical complications and recurrence. Indeed, bowel resection in Crohn’s disease (CD) patients has a high surgical recurrence rate. In this review, we examined the IBD inflammatory pathways, the current surgical treatments, and the almost inevitable recurrence. The question that might arise is if the cure of intestinal CD is to be found in the surgical approach. A selective search of two databases (PubMed and the Cochrane Library) has been carried out without considering a specific time horizon as inclusion criteria. The scope of this literature review was investigating on the role of inflammation in the management of CD. The following key words have been used to develop the query string: (i) inflammation; (ii) Crohn’s disease; (iii) surgery; and (iv) postsurgical recurrence.
Published: 2020

7. Endoscopic Double-Pigtail Catheter (EDPC) Internal Drainage as First-Line Treatment of Gastric Leak: A Case Series during Laparoscopic Sleeve Gastrectomy Learning Curve for Morbid Obesity

Author: Gianni Lazzarin, Alessandra Di Sibio, Beatrice Pessia, Francesco Carlei, Michele Marchese, Antonio Giuliani, Marino Di Furia, Carla Di Giacomo, Loreto Lombardi, Mario Schietroma, and Lucia Romano
Subjects: Leak, medicine.medical_specialty, Sleeve gastrectomy, Laparoscopic sleeve gastrectomy, RD1-811, Article Subject, business.industry, medicine.medical_treatment, 030209 endocrinology & metabolism, Retrospective cohort study, Gastric leak, Surgery, Morbid obesity, 03 medical and health sciences, Catheter, 0302 clinical medicine, medicine, 030211 gastroenterology & hepatology, Complication, business, Research Article
Abstract: Objectives. The prevalence of morbid obesity has dramatically increased over the last several decades worldwide, currently reaching epidemic proportions. Gastric leak (GL) remains the potentially fatal main complication after sleeve gastrectomy (SG) for morbid obesity. To our knowledge, there are no standardized guidelines for GL treatment after laparoscopic sleeve gastrectomy (LSG) yet. The aim of this study was to represent our institutional preliminary experience using the endoscopic double-pigtail catheter (EDPC) as the method of internal drainage and propose it as first-line treatment in case of GL after LSG. Methods. One hundred and seventeen patients were admitted to our surgical department and underwent laparoscopic sleeve gastrectomy (LSG) for morbid obesity from March 2014 to June 2019. In 5 patients (4.3%) of our series, GL occurred as a complication of LSG. EPDC was the stand-alone procedure of internal drainage and GL first-line treatment. The internal pig tail was endoscopically removed from 30th to 40th POD in all cases. Results. Present data (clinical, biochemical, and instrumental tests) showed a complete resolution of GL, with promotion of a pseudodiverticula and complete re-epithelialization of leak. Follow-up was more strict than usual (clinical visit and biochemical test on 7th, 14th, and 21st day after discharge; a CT scan with gastrografin on 30th day from discharge if clinical visit and exams were normal). Conclusion. This was a preliminary retrospective observational study, conducted on 5 patients affected by GL as a complication of LSG for morbid obesity. EDPC maintains the safety, efficacy, and nonexpensive characteristic and may be proposed as better first-line treatment in case of GL after bariatric surgery.
Published: 2020

8. Impact of asymptomatic COVID-19 patients in global surgical practice during the COVID-19 pandemic

Author: Bellato, V., Konishi, T., Pellino, G., An, Y., Piciocchi, A., Khanna, K., Campanelli, M., Efetov, S., Sica, G. S., Kefleyesus, A., Hoofwijk, A. G. M., Eldaly, A. S., Gonzalez, A., Jawad, A., Jooma, A., Hafez, A. M., Rubio, A. V., Landaluce-Olavarria, A., Wu, A., Nagatsu, A., Inoue, A., Kanamoto, A., Ouchi, A., El-Hussuna, A., Vazquez-Melero, A., Wolthuis, A. M., Peral, A. M., Lozano, A. C., Efremov, A., Ryasantsev, A. V., Giorgio, A. D., Parente, A., Tamburrini, A., Alo, A., Forero-Torres, A., Vahrmeijer, A. L., Varabei, A., Hinojosa, S., Balkan, A. Z. A., Frontali, A., Oleg, A., Soler-Silva, A., Makni, A., Andre, A., Cabrera, A. M. G., Fernandez, A. M. G., Minaya-Bravo, A. M., Rodriguez-Sanchez, A., Musina, A. -M., Pangeni, A., Zolotko, A., Tonoyan, A., Balla, A., Belli, A., Cavallaro, A., Chierici, A., Divizia, A., Bucci, A. F., Salido, A. J., Morini, A., Muratore, A., Vignali, A., Chitul, A., Sebastian, D. A., Pcolkins, A., Shchegolev, A., Hollenbeck, A., Wisneski, A., Iossa, A., D'Amore, A., Hunter, A., Hesketh, A. J., Brocca, A. L., Spinelli, A., Caires, A., D'Alessandro, A., Correo, A. F. S. L., Macri, A., Navarro-Sanchez, A., Pronk, A., Akunc, A., Mehri, A., Pelta, A., Papadopoulos, A., Kechagias, A., Rashid, A., Ramazanov, A., Chandio, A., Kohyama, A., Nishimura, A., Ohkawa, A., Dulskas, A., Jamal, A., Mariani, A., Unal, A. G., Karagoz, A., Ozkan, B. B., Salih, B., Gulcu, B., Pessia, B., Martin-Perez, B., Ielpo, B., Tulelli, B., Yang, B., Mhamed, B., Murphy, B., Pirozzi, B. M., Sensi, B., Langenhoff, B., Belevi, B., Guney, B., Ng, C., Rueda, C., Roxburgh, C. S., Feo, C. V., Ferrari, C., Gazia, C., Pratesi, C., Ratto, C., Santacruz, C. C., Arroyave, C. R. M., Macias, C., Fernandez, C. G., Fernandez, C. C., Curtis-Martinez, C., Fortmann, C., Kim, C., Galeano, C. U., Barroso, C., Baldi, C., Foppa, C., Formisano, C., Li, C., Ding, C., Wang, C., Iacusso, C., Yang, C., Pizzera, C., Skias, C., Chouliras, C., Liakos, C., Matsuda, C., C. -Y., Wu, Ozaslan, C., Tanda, C., Tommaso, C. M., Dagorno, C., Ramos, C. P. A., Arcudi, C., Coco, C., Morales, C. M., Ali, M. Z., De Azevedo, C. T. M., Lozano, C. C., Sala, C., Leo, C. A., Scarpa, C. R., Ferro, C. V., Fernandez, C. M., Morales-Garcia, D., Nakano, D., Cristian, D., Hechtl, D., Canovas, D. T., Calabrese, D., Rega, D., Ferraro, D., Morezzi, D., Sommacale, D., Brogden, D., Miskovic, D., Merlini, D., Pertile, D., Coniglio, D., Zhu, D., Wu, D., Coletta, D., Rubio, D. R., Sasia, D., Fillipov, D., Russiello, D., Dardanov, D., Consten, E. C. J., Smolskas, E., Muttillo, E. M., Jones, E., Sunami, E., Etienne, E. -H., Chalkiadaki, E., Giacomelli, E., Karbovnichaya, E., Ruiz-Ucar, E., Guaitoli, E., Samadov, E., Jovine, E., Treppiedi, E., Vaterlini, E. M., Zambaiti, E., Moggia, E., Coetzee, E., Chisari, E., D'Errico, E., Ciofic, E., Pena, E., Kurt, E., Balik, E., Gunay, E., Sivrikoz, E., Andolfi, E., Araimo, E., Lucci, E., Opocher, E., Pinotti, E., Rubino, E., Reyhan, E., Mazzotta, E., Navarro, E. B., El-Helou, E., Licardie-Bolanos, E., Porto, E. I., Contreras, E., Boerma, E. -J., Cianchi, F., Marino, F., Uggeri, F., Han, F., Calculli, F., Falaschi, F., Ghignone, F., Perrone, F., Borghi, F., Garcia, F., Agresta, F., Cananzi, F. C. M., Mendoza-Moreno, F., Cengiz, F., Almeida, F. M., Baracchi, F., Carannante, F., Torre, F. L., Fernandes, F., Friedmacher, F., Grama, F., Carissimi, F., Pecchini, F., Bianco, F., Colombo, F., Ferrara, F., Litta, F., Carrano, F. M., Martignoni, F., Tasselli, F. M., Milone, F., Pata, F., Sammartino, F., Zambianchi, F., Barragan, F., Herrero, F., Schlottmann, F., Den Boer, F. C., Pfeffer, F., Fujita, F., Navarra, G., Herrera-Almario, G., Pozzo, G., Capolupo, G. T., Van Ramshorst, G. H., Liscia, G., Gallo, G., Asawa, G., Wang, G., Raiyani, G., Beets, G., Naval, G. S., Jin, G., Chang, G. J., Saakian, G., Kahane, G., Borroni, G., Secco, G. L., Baiocchi, G. L., Baronio, G., Pagano, G., Pattacini, G. C., Lisi, G., Milito, G., Sinibaldi, G., Serrao, G., Bagaglini, G., Sarro, G., Brisinda, G., Candilio, G., Mangiameli, G., Giuliani, G., Martin-Martin, G. P., Bodzin, G., Leon, G., Mackay, G., Vasil, G., Palmisano, G., Giovanna, G. M., Fernandez, G. C., Steingel, G. B., Zhang, G., Choi, G. S., Chen, H., Hirose, H., Kayano, H., Ulgur, H. S., Impellizzeri, H., Ariola, H., Liu, H., Medina, H., Miyauchi, H., Takahashi, H., Hayashi, H., Ishikawa, H., Ishida, H., De Vries, H., Ulman, H., Kon, H., Ota, H., Akamatsu, H., Tamagawa, H., Shoji, H., Egi, H., Matsubara, H., Miki, H., Elfeki, H., Lin, H. -H., Giani, I., Caravaca-Garcia, I., Takemasa, I., Angriman, I., Negoi, I., Volkova, I., Russo, I., Kronberger, I. E., Shageev, I., Aydin, I., Guzman, I. M., Novak, I., Giuliano, I., Rachmuth, J., Ngu, J. C. -Y., Glasbey, J., Stoot, J., Zatecky, J., Melenhorst, J., Van Der Wal, J. B. C., Leijtens, J., Bogach, J., Elliott, J., De Wilt, J. H. W., Han, J., Cui, J., Liu, J., Khan, J., Wirawan, J. P., Zhang, J., Manyari, J. D. O., Doerner, J., Bock, J., Konsten, J., Castro, J. M., Grobas, J. P., Pinto, J. P., Juloski, J., Laina, J. L. B., Solorzano, J. J., Lopez, J. R. G., Li, J., Watanabe, J., Kwak, J. -M., Hasegawa, J., Hiro, J., Sergey, K., Zhang, K., Nagahori, K., Martinez, K., Tokuhara, K., Danno, K., Uehara, K., Yoshimatsu, K., Ehara, K., Ueda, K., Suda, K., Yamamoto, K., Ishimaru, K., Kimura, K., Hirata, K., Deen, K., Imaizumi, K., Yamada, J., Tanakura, K., Rida, K., Sugimoto, K., Kotaro, K., Shi, K., Okabayashi, K., Hida, K., Kataoka, K., Hongo, K., Xia, K., Tseng, L., Reime, L., Lorenzon, L., Ruano, L. M., Siragusa, L., Zhou, L., De Nes, L., Brandariz, L., Morini, L., Petagna, L., Ripamonti, L., Martinez, L. H., Pio, L., Sacco, L., Carvalho, L., Zorcolo, L., Perez-Sanchez, L. E., Esparza, L. H. R., Aguilar, L. T., Garner, M., Sugimoto, M., Nagashima, M., Shiozawa, M., Simone, M., Ferrer-Marquez, M., Carvalho, M., Alifano, M., Arganini, M., Calussi, M., Catarci, M., Allaix, M. E., Forlin, M., Milone, M., Paci, M., Franceschilli, M., Fodor, M., Antipova, M., Martos, M. B., Giuffrida, M. C., Tabernilla, M. D., Quiros, M. J. A., Lemma, M., Correo, M. L. R. D., Malowiecka, M., Bellomo, M. P., Fernandez, M. R., Socias, M., Rizk, M., Aurora, M., Antolinez, M. A., Ninkovic, M., Giuffrida, M., Leeuwenburgh, M. M. N., De Roos, M. A. J., Lara, M. C., Agustin, M. C., Cuadrado, M., Pascual, M., Lemmerer, M., Carlos, R., Okamoto, M., Miyo, M., Inomata, M., Ikenaga, M., Tsujie, M., Yasuno, M., Kotake, M., Sato, M., Yasui, M., Lavazza, M., Rottoli, M., Zuin, M., Zuluaga, M., Cervellera, M., Cesari, M., Zizzo, M., Garino, M., Ghirardi, M., Montuori, M., Podda, M., Santarelli, M., Koc, M. A., Baini, M., De Cillia, M., De Rosa, M., Manigrasso, M., Zuolo, M., Cunha, M. F., Misca, M., Slavchev, M., Danilov, M., Shigaev, M., Martens, M., Kobayashi, M., Ren, M., Ishizuka, M., Hassan, M. M., Siblini, M., Sahloul, M., Keramati, M. R., Karunakaran, M., Markel, M., Majeed, M., Younis, M. U., Akin, M. I., Laraibe, M., Derebey, M., Kendirci, M., Fukunaga, M., Matsubara, N., Ordaz, N. E. C., Samalavicius, N. E., Keeratibharat, N., De Angelis, N., Gica, N., Mariani, N. M., Ramino, N., Falco, N., Smart, N., De Korte, N., Kok, N. F. M., Jamieson, N. B., Aberyasev, N., Bruklich, N., Ichikawa, N., Miyoshi, N., De Palma, N., Figueiredo, N., Torrecilla, N. O., Dybov, O. G., Yudin, O., Crepin, O., Gomez, O., Sert, O. Z., Lominchar, P. L., Menendez, P., De Nardi, P., Tejedor, P., Jordan, P., Tan, P., Marsanic, P., Natalya, P., Banos, P. P., Rebasa, P., Neary, P. M., Tanis, P., Giustacchini, P., Anoldo, P., Concejo, P., Cao, P., Chandrasinghe, P., Abeyratne, P., Wang, Q., Klicks, R. J., Mukai, R., Riquelme, R. F., De Luca, R., Galli, R., Gianesini, R., Moorjani, R. G., Deshpande, R. K., Gorter, R., Ledesma, R. L., Ruslan, R., Chhabra, R., Talreja-Pelaez, R., Suzuki, R., Balestri, R., Rosati, R., Kiblawi, R., Martins, R., Angelico, R., Tutino, R., Persiani, R., Pollastri, R., Lopez, R. G., Perez, R. O., Hompes, R., Lukanin, R., Roser Termes Serra, R., Brunaccino, R., Nakanishi, R., Stefan, S., Hernandez, S. P. S., Carlo, S. D., Ingallinella, S., Domoto, S., Ikeda, S., Mikalauskas, S., Kim, S. H., Mantova, S., Barbuta, S., Li, S., Yamaguchi, S., Yamagishi, S., Homma, S., Tsujinaka, S., Yoshioka, S., Mori, S., Tewari, S., Rayman, S., Horiuchi, S., Matoba, S., Morita, S., Yaman, S., Vigna, S., Testa, S., Ng, S., Deidda, S., Cicconi, S., Maria, S. D., Sibio, S., Ersoz, S., Pejkova, S., Altarifi, S., He, S., Malakorn, S., Meindert, S., Sumikawa, S., Parmar, S., Uranitsch, S., D'Ugo, S., Giuliani, S., Breukink, S., Lee, S. -H., Hata, T., Ishikawa, T., Akiyoshi, T., Azuma, T., Kobatake, T., Fukuzaki, T., Aiyama, T., Yamada, T., Garmanova, T., Gomez-Sanchez, T., Yamaguchi, T., De Jesus Flores, T., Usub, T., Tsuruma, T., Shimizu, T., Hristov, T. G., Van Loon, T., Funakoshi, T., Manzia, T. M., Kiyomatsu, T., Katayama, T., Akagi, T., Mizushima, T., Kazuhito, U., Elmore, U., Grossi, U., Truchalev, V. A., Rodriguez, V. S., Testa, V., Tonini, V., Celentano, V., Nekoval, V. M., Bettencourt, V., Mammadov, V., Leyva, V. A. G., Mariscal, V. G. O., Seid, V. E., Klemann, V., Turrado-Rodriguez, V., Papagni, V., Vento, V., Frering, V., Vigorita, V., Petrove, V. V., Lyadov, V., Fu, W., Mi, W., Jeong, W. K., Leclercq, W. K. G., De Sousa, X., Zhao, X., Li, X., Wang, X., Yang, X., Zhang, X., Zhen, Y., Dong, Y., Erushevich, Y., Takii, Y., Sumi, Y., Loli, Y. T., Yifat, Y. L., Shimada, Y., Nabeya, Y., Ide, Y., Wu, Y., Tsukada, Y., Miyamoto, Y., Toiyama, Y., Fujie, Y., Kaneko, Y., Mokutani, Y., Fujii, Y., Kanemitsu, Y., Medkova, Y., Chen, Y., Ruiz, Y. G., Kinugasa, Y., Sow, Z., Razzaq, Z., Wang, Z., Liu, Z., Han, Z., Tai, Z., Lai, Z., Z. Q., Ng, Dambrauskas, Z., Center of Experimental and Molecular Medicine, Graduate School, ACS - Pulmonary hypertension & thrombosis, AII - Infectious diseases, Surgery, Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Surgery, Amsterdam Reproduction & Development (AR&D), Bellato V., Konishi T., Pellino G., An Y., Piciocchi A., Sensi B., Siragusa L., Khanna K., Pirozzi B.M., Franceschilli M., Campanelli M., Efetov S., Sica G.S., Kefleyesus A., Hoofwijk A.G.M., Eldaly A.S., Gonzalez A., Jawad A., Jooma A., Hafez A.M., Rubio A.V., Landaluce-Olavarria A., Wu A., Nagatsu A., Inoue A., Kanamoto A., Ouchi A., El-Hussuna A., Vazquez-Melero A., Wolthuis A.M., Peral A.M., Lozano A.C., Efremov A., Ryasantsev A.V., Di Giorgio A., Parente A., Tamburrini A., Alo A., Forero-Torres A., Vahrmeijer A.L., Varabei A., Hinojosa S., Balkan A.Z.A., Frontali A., Oleg A., Soler-Silva A., Makni A., Andre A., Cabrera A.M.G., Fernandez A.M.G., Minaya-Bravo A.M., Rodriguez-Sanchez A., Musina A.-M., Pangeni A., Zolotko A., Tonoyan A., Balla A., Belli A., Cavallaro A., Chierici A., Divizia A., Bucci A.F., Salido A.J., Morini A., Muratore A., Vignali A., Chitul A., Sebastian D.A., Pcolkins A., Shchegolev A., Hollenbeck A., Wisneski A., Iossa A., D'Amore A., Hunter A., Hesketh A.J., La Brocca A., Spinelli A., Caires A., D'Alessandro A., Correo A.F.S.L., Macri A., Navarro-Sanchez A., Pronk A., Akunc A., Mehri A., Pelta A., Papadopoulos A., Kechagias A., Rashid A., Ramazanov A., Chandio A., Kohyama A., Nishimura A., Ohkawa A., Dulskas A., Jamal A., Mariani A., Unal A.G., Karagoz A., Ozkan B.B., Salih B., Gulcu B., Pessia B., Martin-Perez B., Ielpo B., Tulelli B., Yang B., Mhamed B., Murphy B., Langenhoff B., Belevi B., Guney B., Ng C., Rueda C., Roxburgh C.S., Feo C.V., Ferrari C., Gazia C., Pratesi C., Ratto C., Santacruz C.C., Arroyave C.R.M., Macias C., Fernandez C.G., Fernandez C.C., Curtis-Martinez C., Fortmann C., Kim C., Galeano C.U., Barroso C., Baldi C., Foppa C., Formisano C., Li C., Ding C., Wang C., Iacusso C., Yang C., Pizzera C., Skias C., Chouliras C., Liakos C., Matsuda C., Wu C.-Y., Ozaslan C., Tanda C., Tommaso C.M., Dagorno C., Ramos C.P.A., Arcudi C., Coco C., Morales C.M., Ali M.Z., Lozano C.C., Sala C., Leo C.A., Scarpa C.R., Ferro C.V., Fernandez C.M., Morales-Garcia D., Nakano D., Cristian D., Hechtl D., Canovas D.T., Calabrese D., Rega D., Ferraro D., Morezzi D., Sommacale D., Brogden D., Miskovic D., Merlini D., Pertile D., Coniglio D., Zhu D., Wu D., Coletta D., Rubio D.R., Sasia D., Fillipov D., Russiello D., Dardanov D., Consten E.C.J., Smolskas E., Muttillo E.M., Jones E., Sunami E., Etienne E.-H., Chalkiadaki E., Giacomelli E., Karbovnichaya E., Ruiz-Ucar E., Guaitoli E., Samadov E., Jovine E., Treppiedi E., Vaterlini E.M., Zambaiti E., Moggia E., Coetzee E., Chisari E., D'Errico E., Ciofic E., Pena E., Kurt E., Balik E., Gunay E., Sivrikoz E., Andolfi E., Araimo E., Lucci E., Opocher E., Pinotti E., Rubino E., Reyhan E., Mazzotta E., Navarro E.B., El-Helou E., Licardie-Bolanos E., Porto E.I., Contreras E., Boerma E.-J., Cianchi F., Marino F., Uggeri F., Han F., Calculli F., Falaschi F., Ghignone F., Perrone F., Borghi F., Garcia F., Agresta F., Cananzi F.C.M., Mendoza-Moreno F., Cengiz F., Almeida F.M., Baracchi F., Carannante F., La Torre F., Fernandes F., Friedmacher F., Grama F., Carissimi F., Pecchini F., Bianco F., Colombo F., Ferrara F., Litta F., Carrano F.M., Martignoni F., Tasselli F.M., Milone F., Pata F., Sammartino F., Zambianchi F., Barragan F., Herrero F., Schlottmann F., Den Boer F.C., Pfeffer F., Fujita F., Navarra G., Herrera-Almario G., Pozzo G., Capolupo G.T., Van Ramshorst G.H., Liscia G., Gallo G., Asawa G., Wang G., Raiyani G., Beets G., Naval G.S., Jin G., Chang G.J., Saakian G., Kahane G., Borroni G., Secco G.L., Baiocchi G.L., Baronio G., Pagano G., Pattacini G.C., Lisi G., Milito G., Sinibaldi G., Serrao G., Bagaglini G., Sarro G., Brisinda G., Candilio G., Mangiameli G., Giuliani G., Martin-Martin G.P., Bodzin G., Leon G., Mackay G., Vasil G., Palmisano G., Giovanna G.M., Fernandez G.C., Steingel G.B., Zhang G., Choi G.S., Chen H., Hirose H., Kayano H., Ulgur H.S., Impellizzeri H., Ariola H., Liu H., Medina H., Miyauchi H., Takahashi H., Hayashi H., Ishikawa H., Ishida H., De Vries H., Ulman H., Kon H., Ota H., Akamatsu H., Tamagawa H., Shoji H., Egi H., Matsubara H., Miki H., Elfeki H., Lin H.-H., Giani I., Caravaca-Garcia I., Takemasa I., Angriman I., Negoi I., Volkova I., Russo I., Kronberger I.E., Shageev I., Aydin I., Mora Guzman I., Novak I., Giuliano I., Rachmuth J., Ngu J.C.-Y., Glasbey J., Stoot J., Zatecky J., Melenhorst J., Van Der Wal J.B.C., Leijtens J., Bogach J., Elliott J., De Wilt J.H.W., Han J., Cui J., Liu J., Khan J., Wirawan J.P., Zhang J., Manyari J.D.O., Doerner J., Bock J., Konsten J., Castro J.M., Grobas J.P., Pereira J., Juloski J., Laina J.L.B., Solorzano J.J., Lopez J.R.G., Li J., Watanabe J., Kwak J.-M., Hasegawa J., Hiro J., Sergey K., Zhang K., Nagahori K., Martinez K., Tokuhara K., Danno K., Uehara K., Yoshimatsu K., Ehara K., Ueda K., Suda K., Yamamoto K., Ishimaru K., Kimura K., Hirata K., Deen K., Imaizumi K., Yamada J., Tanakura K., Rida K., Sugimoto K., Kotaro K., Shi K., Okabayashi K., Hida K., Kataoka K., Hongo K., Xia K., Tseng L., Reime L., Lorenzon L., Ruano L.M., Zhou L., De Nes L., Brandariz L., Morini L., Petagna L., Ripamonti L., Martinez L.H., Pio L., Sacco L., Carvalho L., Zorcolo L., Perez-Sanchez L.E., Esparza L.H.R., Aguilar L.T., Garner M., Sugimoto M., Nagashima M., Shiozawa M., Simone M., Ferrer-Marquez M., Carvalho M., Alifano M., Arganini M., Calussi M., Catarci M., Allaix M.E., Forlin M., Milone M., Paci M., Fodor M., Antipova M., Martos M.B., Giuffrida M.C., Tabernilla M.D., Quiros M.J.A., Lemma M., Correo M.L.R.D., Malowiecka M., Bellomo M.P., Fernandez M.R., Socias M., Rizk M., Aurora M., Antolinez M.A., Ninkovic M., Giuffrida M., De Roos M.A.J., Lara M.C., Agustin M.C., Cuadrado M., Pascual M., Lemmerer M., Carlos R., Okamoto M., Miyo M., Inomata M., Ikenaga M., Tsujie M., Yasuno M., Kotake M., Sato M., Yasui M., Lavazza M., Rottoli M., Zuin M., Zuluaga M., Cervellera M., Cesari M., Zizzo M., Garino M., Ghirardi M., Montuori M., Podda M., Santarelli M., Koc M.A., Baini M., Manigrasso M., Zuolo M., Cunha M.F., Misca M., Slavchev M., Danilov M., Shigaev M., Martens M., Kobayashi M., Ren M., Ishizuka M., Hassan M.M., Siblini M., Sahloul M., Keramati M.R., Karunakaran M., Markel M., Majeed M., Younis M.U., Akin M.I., Laraibe M., Derebey M., Kendirci M., Fukunaga M., Matsubara N., Ordaz N.E.C., Samalavicius N.E., Keeratibharat N., de Angelis N., Gica N., Mariani N.M., Ramino N., Falco N., Smart N., De Korte N., Kok N.F.M., Jamieson N.B., Aberyasev N., Bruklich N., Ichikawa N., Miyoshi N., De Palma N., Figueiredo N., Torrecilla N.O., Dybov O.G., Yudin O., Crepin O., Gomez O., Sert O.Z., Lominchar P.L., Menendez P., De Nardi P., Tejedor P., Jordan P., Tan P., Marsanic P., Natalya P., Banos P.P., Rebasa P., Neary P.M., Tanis P., Giustacchini P., Anoldo P., Concejo P., Cao P., Chandrasinghe P., Abeyratne P., Wang Q., Klicks R.J., Riquelme R.F., Galli R., Gianesini R., Moorjani R.G., Deshpande R.K., Gorter R., Ledesma R.L., Ruslan R., Chhabra R., Talreja-Pelaez R., Suzuki R., Balestri R., Rosati R., Kiblawi R., Martins R., Angelico R., Tutino R., Persiani R., Pollastri R., Lopez R.G., Perez R.O., Hompes R., Lukanin R., Roser Termes Serra R., Brunaccino R., Nakanishi R., Stefan S., Hernandez S.P.S., Di Carlo S., Ingallinella S., Domoto S., Ikeda S., Mikalauskas S., Kim S.H., Mantova S., Barbuta S., Li S., Yamaguchi S., Yamagishi S., Homma S., Tsujinaka S., Yoshioka S., Mori S., Tewari S., Rayman S., Horiuchi S., Matoba S., Morita S., Yaman S., Vigna S., Testa S., Ng S., Deidda S., Cicconi S., Di Maria S., Sibio S., Ersoz S., Pejkova S., Altarifi S., He S., Malakorn S., Meindert S., Sumikawa S., Parmar S., Uranitsch S., D'ugo S., Giuliani S., Breukink S., Lee S.-H., Hata T., Ishikawa T., Akiyoshi T., Azuma T., Kobatake T., Fukuzaki T., Aiyama T., Yamada T., Garmanova T., Gomez-Sanchez T., Yamaguchi T., Flores T.D.J., Usub T., Tsuruma T., Shimizu T., Hristov T.G., Van Loon T., Funakoshi T., Manzia T.M., Kiyomatsu T., Katayama T., Kazuhito U., Elmore U., Grossi U., Truchalev V.A., Rodriguez V.S., Testa V., Tonini V., Celentano V., Bettencourt V., Mammadov V., Leyva V.A.G., Mariscal V.G.O., Seid V.E., Klemann V., Turrado-Rodriguez V., Papagni V., Vento V., Frering V., Vigorita V., Petrove V.V., Lyadov V., Fu W., Mi W., Jeong W.K., Leclercq W.K.G., De Sousa X., Zhao X., Li X., Wang X., Yang X., Zhang X., Dong Y., Erushevich Y., Takii Y., Sumi Y., Loli Y.T., Yifat Y.L., Shimada Y., Nabeya Y., Ide Y., Wu Y., Tsukada Y., Miyamoto Y., Toiyama Y., Fujie Y., Kaneko Y., Mokutani Y., Fujii Y., Kanemitsu Y., Medkova Y., Chen Y., Ruiz Y.G., Kinugasa Y., Sow Z., Razzaq Z., Wang Z., Liu Z., Han Z., Tai Z., Lai Z., Ng Z.Q., Dambrauskas Z., Bellato, V., Konishi, T., Pellino, G., An, Y., Piciocchi, A., Sensi, B., Siragusa, L., Khanna, K., Pirozzi, B. M., Franceschilli, M., Campanelli, M., Efetov, S., Sica, G. S., Kefleyesus, A., Hoofwijk, A. G. M., Eldaly, A. S., Gonzalez, A., Jawad, A., Jooma, A., Hafez, A. M., Rubio, A. V., Landaluce-Olavarria, A., Wu, A., Nagatsu, A., Inoue, A., Kanamoto, A., Ouchi, A., El-Hussuna, A., Vazquez-Melero, A., Wolthuis, A. M., Peral, A. M., Lozano, A. C., Efremov, A., Ryasantsev, A. V., Di Giorgio, A., Parente, A., Tamburrini, A., Alo, A., Forero-Torres, A., Vahrmeijer, A. L., Varabei, A., Hinojosa, S., Balkan, A. Z. A., Frontali, A., Oleg, A., Soler-Silva, A., Makni, A., Andre, A., Cabrera, A. M. G., Fernandez, A. M. G., Minaya-Bravo, A. M., Rodriguez-Sanchez, A., Musina, A. -M., Pangeni, A., Zolotko, A., Tonoyan, A., Balla, A., Belli, A., Cavallaro, A., Chierici, A., Divizia, A., Bucci, A. F., Salido, A. J., Morini, A., Muratore, A., Vignali, A., Chitul, A., Sebastian, D. A., Pcolkins, A., Shchegolev, A., Hollenbeck, A., Wisneski, A., Iossa, A., D'Amore, A., Hunter, A., Hesketh, A. J., La Brocca, A., Spinelli, A., Caires, A., D'Alessandro, A., Correo, A. F. S. L., Macri, A., Navarro-Sanchez, A., Pronk, A., Akunc, A., Mehri, A., Pelta, A., Papadopoulos, A., Kechagias, A., Rashid, A., Ramazanov, A., Chandio, A., Kohyama, A., Nishimura, A., Ohkawa, A., Dulskas, A., Jamal, A., Mariani, A., Unal, A. G., Karagoz, A., Ozkan, B. B., Salih, B., Gulcu, B., Pessia, B., Martin-Perez, B., Ielpo, B., Tulelli, B., Yang, B., Mhamed, B., Murphy, B., Langenhoff, B., Belevi, B., Guney, B., Ng, C., Rueda, C., Roxburgh, C. S., Feo, C. V., Ferrari, C., Gazia, C., Pratesi, C., Ratto, C., Santacruz, C. C., Arroyave, C. R. M., Macias, C., Fernandez, C. G., Fernandez, C. C., Curtis-Martinez, C., Fortmann, C., Kim, C., Galeano, C. U., Barroso, C., Baldi, C., Foppa, C., Formisano, C., Li, C., Ding, C., Wang, C., Iacusso, C., Yang, C., Pizzera, C., Skias, C., Chouliras, C., Liakos, C., Matsuda, C., Wu, C. -Y., Ozaslan, C., Tanda, C., Tommaso, C. M., Dagorno, C., Ramos, C. P. A., Arcudi, C., Coco, C., Morales, C. M., Ali, M. Z., Lozano, C. C., Sala, C., Leo, C. A., Scarpa, C. R., Ferro, C. V., Fernandez, C. M., Morales-Garcia, D., Nakano, D., Cristian, D., Hechtl, D., Canovas, D. T., Calabrese, D., Rega, D., Ferraro, D., Morezzi, D., Sommacale, D., Brogden, D., Miskovic, D., Merlini, D., Pertile, D., Coniglio, D., Zhu, D., Wu, D., Coletta, D., Rubio, D. R., Sasia, D., Fillipov, D., Russiello, D., Dardanov, D., Consten, E. C. J., Smolskas, E., Muttillo, E. M., Jones, E., Sunami, E., Etienne, E. -H., Chalkiadaki, E., Giacomelli, E., Karbovnichaya, E., Ruiz-Ucar, E., Guaitoli, E., Samadov, E., Jovine, E., Treppiedi, E., Vaterlini, E. M., Zambaiti, E., Moggia, E., Coetzee, E., Chisari, E., D'Errico, E., Ciofic, E., Pena, E., Kurt, E., Balik, E., Gunay, E., Sivrikoz, E., Andolfi, E., Araimo, E., Lucci, E., Opocher, E., Pinotti, E., Rubino, E., Reyhan, E., Mazzotta, E., Navarro, E. B., El-Helou, E., Licardie-Bolanos, E., Porto, E. I., Contreras, E., Boerma, E. -J., Cianchi, F., Marino, F., Uggeri, F., Han, F., Calculli, F., Falaschi, F., Ghignone, F., Perrone, F., Borghi, F., Garcia, F., Agresta, F., Cananzi, F. C. M., Mendoza-Moreno, F., Cengiz, F., Almeida, F. M., Baracchi, F., Carannante, F., La Torre, F., Fernandes, F., Friedmacher, F., Grama, F., Carissimi, F., Pecchini, F., Bianco, F., Colombo, F., Ferrara, F., Litta, F., Carrano, F. M., Martignoni, F., Tasselli, F. M., Milone, F., Pata, F., Sammartino, F., Zambianchi, F., Barragan, F., Herrero, F., Schlottmann, F., Den Boer, F. C., Pfeffer, F., Fujita, F., Navarra, G., Herrera-Almario, G., Pozzo, G., Capolupo, G. T., Van Ramshorst, G. H., Liscia, G., Gallo, G., Asawa, G., Wang, G., Raiyani, G., Beets, G., Naval, G. S., Jin, G., Chang, G. J., Saakian, G., Kahane, G., Borroni, G., Secco, G. L., Baiocchi, G. L., Baronio, G., Pagano, G., Pattacini, G. C., Lisi, G., Milito, G., Sinibaldi, G., Serrao, G., Bagaglini, G., Sarro, G., Brisinda, G., Candilio, G., Mangiameli, G., Giuliani, G., Martin-Martin, G. P., Bodzin, G., Leon, G., Mackay, G., Vasil, G., Palmisano, G., Giovanna, G. M., Fernandez, G. C., Steingel, G. B., Zhang, G., Choi, G. S., Chen, H., Hirose, H., Kayano, H., Ulgur, H. S., Impellizzeri, H., Ariola, H., Liu, H., Medina, H., Miyauchi, H., Takahashi, H., Hayashi, H., Ishikawa, H., Ishida, H., De Vries, H., Ulman, H., Kon, H., Ota, H., Akamatsu, H., Tamagawa, H., Shoji, H., Egi, H., Matsubara, H., Miki, H., Elfeki, H., Lin, H. -H., Giani, I., Caravaca-Garcia, I., Takemasa, I., Angriman, I., Negoi, I., Volkova, I., Russo, I., Kronberger, I. E., Shageev, I., Aydin, I., Guzman, I. M., Novak, I., Giuliano, I., Rachmuth, J., Ngu, J. C. -Y., Glasbey, J., Stoot, J., Zatecky, J., Melenhorst, J., Van Der Wal, J. B. C., Leijtens, J., Bogach, J., Elliott, J., De Wilt, J. H. W., Han, J., Cui, J., Liu, J., Khan, J., Wirawan, J. P., Zhang, J., Manyari, J. D. O., Doerner, J., Bock, J., Konsten, J., Castro, J. M., Grobas, J. P., Pereira, J., Juloski, J., Laina, J. L. B., Solorzano, J. J., Lopez, J. R. G., Li, J., Watanabe, J., Kwak, J. -M., Hasegawa, J., Hiro, J., Sergey, K., Zhang, K., Nagahori, K., Martinez, K., Tokuhara, K., Danno, K., Uehara, K., Yoshimatsu, K., Ehara, K., Ueda, K., Suda, K., Yamamoto, K., Ishimaru, K., Kimura, K., Hirata, K., Deen, K., Imaizumi, K., Yamada, J., Tanakura, K., Rida, K., Sugimoto, K., Kotaro, K., Shi, K., Okabayashi, K., Hida, K., Kataoka, K., Hongo, K., Xia, K., Tseng, L., Reime, L., Lorenzon, L., Ruano, L. M., Zhou, L., De Nes, L., Brandariz, L., Morini, L., Petagna, L., Ripamonti, L., Martinez, L. H., Pio, L., Sacco, L., Carvalho, L., Zorcolo, L., Perez-Sanchez, L. E., Esparza, L. H. R., Aguilar, L. T., Garner, M., Sugimoto, M., Nagashima, M., Shiozawa, M., Simone, M., Ferrer-Marquez, M., Carvalho, M., Alifano, M., Arganini, M., Calussi, M., Catarci, M., Allaix, M. E., Forlin, M., Milone, M., Paci, M., Fodor, M., Antipova, M., Martos, M. B., Giuffrida, M. C., Tabernilla, M. D., Quiros, M. J. A., Lemma, M., Correo, M. L. R. D., Malowiecka, M., Bellomo, M. P., Fernandez, M. R., Socias, M., Rizk, M., Aurora, M., Antolinez, M. A., Ninkovic, M., Giuffrida, M., De Roos, M. A. J., Lara, M. C., Agustin, M. C., Cuadrado, M., Pascual, M., Lemmerer, M., Carlos, R., Okamoto, M., Miyo, M., Inomata, M., Ikenaga, M., Tsujie, M., Yasuno, M., Kotake, M., Sato, M., Yasui, M., Lavazza, M., Rottoli, M., Zuin, M., Zuluaga, M., Cervellera, M., Cesari, M., Zizzo, M., Garino, M., Ghirardi, M., Montuori, M., Podda, M., Santarelli, M., Koc, M. A., Baini, M., Manigrasso, M., Zuolo, M., Cunha, M. F., Misca, M., Slavchev, M., Danilov, M., Shigaev, M., Martens, M., Kobayashi, M., Ren, M., Ishizuka, M., Hassan, M. M., Siblini, M., Sahloul, M., Keramati, M. R., Karunakaran, M., Markel, M., Majeed, M., Younis, M. U., Akin, M. I., Laraibe, M., Derebey, M., Kendirci, M., Fukunaga, M., Matsubara, N., Ordaz, N. E. C., Samalavicius, N. E., Keeratibharat, N., de Angelis, N., Gica, N., Mariani, N. M., Ramino, N., Falco, N., Smart, N., De Korte, N., Kok, N. F. M., Jamieson, N. B., Aberyasev, N., Bruklich, N., Ichikawa, N., Miyoshi, N., De Palma, N., Figueiredo, N., Torrecilla, N. O., Dybov, O. G., Yudin, O., Crepin, O., Gomez, O., Sert, O. Z., Lominchar, P. L., Menendez, P., De Nardi, P., Tejedor, P., Jordan, P., Tan, P., Marsanic, P., Natalya, P., Banos, P. P., Rebasa, P., Neary, P. M., Tanis, P., Giustacchini, P., Anoldo, P., Concejo, P., Cao, P., Chandrasinghe, P., Abeyratne, P., Wang, Q., Klicks, R. J., Riquelme, R. F., Galli, R., Gianesini, R., Moorjani, R. G., Deshpande, R. K., Gorter, R., Ledesma, R. L., Ruslan, R., Chhabra, R., Talreja-Pelaez, R., Suzuki, R., Balestri, R., Rosati, R., Kiblawi, R., Martins, R., Angelico, R., Tutino, R., Persiani, R., Pollastri, R., Lopez, R. G., Perez, R. O., Hompes, R., Lukanin, R., Roser Termes Serra, R., Brunaccino, R., Nakanishi, R., Stefan, S., Hernandez, S. P. S., Di Carlo, S., Ingallinella, S., Domoto, S., Ikeda, S., Mikalauskas, S., Kim, S. H., Mantova, S., Barbuta, S., Li, S., Yamaguchi, S., Yamagishi, S., Homma, S., Tsujinaka, S., Yoshioka, S., Mori, S., Tewari, S., Rayman, S., Horiuchi, S., Matoba, S., Morita, S., Yaman, S., Vigna, S., Testa, S., Ng, S., Deidda, S., Cicconi, S., Di Maria, S., Sibio, S., Ersoz, S., Pejkova, S., Altarifi, S., He, S., Malakorn, S., Meindert, S., Sumikawa, S., Parmar, S., Uranitsch, S., D'Ugo, S., Giuliani, S., Breukink, S., Lee, S. -H., Hata, T., Ishikawa, T., Akiyoshi, T., Azuma, T., Kobatake, T., Fukuzaki, T., Aiyama, T., Yamada, T., Garmanova, T., Gomez-Sanchez, T., Yamaguchi, T., Flores, T. D. J., Usub, T., Tsuruma, T., Shimizu, T., Hristov, T. G., Van Loon, T., Funakoshi, T., Manzia, T. M., Kiyomatsu, T., Katayama, T., Kazuhito, U., Elmore, U., Grossi, U., Truchalev, V. A., Rodriguez, V. S., Testa, V., Tonini, V., Celentano, V., Bettencourt, V., Mammadov, V., Leyva, V. A. G., Mariscal, V. G. O., Seid, V. E., Klemann, V., Turrado-Rodriguez, V., Papagni, V., Vento, V., Frering, V., Vigorita, V., Petrove, V. V., Lyadov, V., Fu, W., Mi, W., Jeong, W. K., Leclercq, W. K. G., De Sousa, X., Zhao, X., Li, X., Wang, X., Yang, X., Zhang, X., Dong, Y., Erushevich, Y., Takii, Y., Sumi, Y., Loli, Y. T., Yifat, Y. L., Shimada, Y., Nabeya, Y., Ide, Y., Wu, Y., Tsukada, Y., Miyamoto, Y., Toiyama, Y., Fujie, Y., Kaneko, Y., Mokutani, Y., Fujii, Y., Kanemitsu, Y., Medkova, Y., Chen, Y., Ruiz, Y. G., Kinugasa, Y., Sow, Z., Razzaq, Z., Wang, Z., Liu, Z., Han, Z., Tai, Z., Lai, Z., Ng, Z. Q., Dambrauskas, Z., Mora Guzman, I., Rinha, R., Robotics and image-guided minimally-invasive surgery (ROBOTICS), Bellato, V, Konishi, T, Pellino, G, An, Y, Piciocchi, A, Sensi, B, Siragusa, L, Khanna, K, Pirozzi, B, Franceschilli, M, Campanelli, M, Efetov, S, Sica, G, Kefleyesus, A, Hoofwijk, A, Eldaly, A, Gonzalez, A, Jawad, A, Jooma, A, Hafez, A, Rubio, A, Landaluce-Olavarria, A, Wu, A, Nagatsu, A, Inoue, A, Kanamoto, A, Ouchi, A, El-Hussuna, A, Vazquez-Melero, A, Wolthuis, A, Peral, A, Lozano, A, Efremov, A, Ryasantsev, A, Di Giorgio, A, Parente, A, Tamburrini, A, Alo, A, Forero-Torres, A, Vahrmeijer, A, Varabei, A, Hinojosa, S, Balkan, A, Frontali, A, Oleg, A, Soler-Silva, A, Makni, A, Andre, A, Cabrera, A, Fernandez, A, Minaya-Bravo, A, Rodriguez-Sanchez, A, Musina, A, Pangeni, A, Zolotko, A, Tonoyan, A, Balla, A, Belli, A, Cavallaro, A, Chierici, A, Divizia, A, Bucci, A, Salido, A, Morini, A, Muratore, A, Vignali, A, Chitul, A, Sebastian, D, Pcolkins, A, Shchegolev, A, Hollenbeck, A, Wisneski, A, Iossa, A, D'Amore, A, Hunter, A, Hesketh, A, La Brocca, A, Spinelli, A, Caires, A, D'Alessandro, A, Correo, A, Macri, A, Navarro-Sanchez, A, Pronk, A, Akunc, A, Mehri, A, Pelta, A, Papadopoulos, A, Kechagias, A, Rashid, A, Ramazanov, A, Chandio, A, Kohyama, A, Nishimura, A, Ohkawa, A, Dulskas, A, Jamal, A, Mariani, A, Unal, A, Karagoz, A, Ozkan, B, Salih, B, Gulcu, B, Pessia, B, Martin-Perez, B, Ielpo, B, Tulelli, B, Yang, B, Mhamed, B, Murphy, B, Langenhoff, B, Belevi, B, Guney, B, Ng, C, Rueda, C, Roxburgh, C, Feo, C, Ferrari, C, Gazia, C, Pratesi, C, Ratto, C, Santacruz, C, Arroyave, C, Macias, C, Fernandez, C, Curtis-Martinez, C, Fortmann, C, Kim, C, Galeano, C, Barroso, C, Baldi, C, Foppa, C, Formisano, C, Li, C, Ding, C, Wang, C, Iacusso, C, Yang, C, Pizzera, C, Skias, C, Chouliras, C, Liakos, C, Matsuda, C, Wu, C, Ozaslan, C, Tanda, C, Tommaso, C, Dagorno, C, Ramos, C, Arcudi, C, Coco, C, Morales, C, Ali, M, Lozano, C, Sala, C, Leo, C, Scarpa, C, Ferro, C, Morales-Garcia, D, Nakano, D, Cristian, D, Hechtl, D, Canovas, D, Calabrese, D, Rega, D, Ferraro, D, Morezzi, D, Sommacale, D, Brogden, D, Miskovic, D, Merlini, D, Pertile, D, Coniglio, D, Zhu, D, Wu, D, Coletta, D, Rubio, D, Sasia, D, Fillipov, D, Russiello, D, Dardanov, D, Consten, E, Smolskas, E, Muttillo, E, Jones, E, Sunami, E, Etienne, E, Chalkiadaki, E, Giacomelli, E, Karbovnichaya, E, Ruiz-Ucar, E, Guaitoli, E, Samadov, E, Jovine, E, Treppiedi, E, Vaterlini, E, Zambaiti, E, Moggia, E, Coetzee, E, Chisari, E, D'Errico, E, Ciofic, E, Pena, E, Kurt, E, Balik, E, Gunay, E, Sivrikoz, E, Andolfi, E, Araimo, E, Lucci, E, Opocher, E, Pinotti, E, Rubino, E, Reyhan, E, Mazzotta, E, Navarro, E, El-Helou, E, Licardie-Bolanos, E, Porto, E, Contreras, E, Boerma, E, Cianchi, F, Marino, F, Uggeri, F, Han, F, Calculli, F, Falaschi, F, Ghignone, F, Perrone, F, Borghi, F, Garcia, F, Agresta, F, Cananzi, F, Mendoza-Moreno, F, Cengiz, F, Almeida, F, Baracchi, F, Carannante, F, La Torre, F, Fernandes, F, Friedmacher, F, Grama, F, Carissimi, F, Pecchini, F, Bianco, F, Colombo, F, Ferrara, F, Litta, F, Carrano, F, Martignoni, F, Tasselli, F, Milone, F, Pata, F, Sammartino, F, Zambianchi, F, Barragan, F, Herrero, F, Schlottmann, F, Den Boer, F, Pfeffer, F, Fujita, F, Navarra, G, Herrera-Almario, G, Pozzo, G, Capolupo, G, Van Ramshorst, G, Liscia, G, Gallo, G, Asawa, G, Wang, G, Raiyani, G, Beets, G, Naval, G, Jin, G, Chang, G, Saakian, G, Kahane, G, Borroni, G, Secco, G, Baiocchi, G, Baronio, G, Pagano, G, Pattacini, G, Lisi, G, Milito, G, Sinibaldi, G, Serrao, G, Bagaglini, G, Sarro, G, Brisinda, G, Candilio, G, Mangiameli, G, Giuliani, G, Martin-Martin, G, Bodzin, G, Leon, G, Mackay, G, Vasil, G, Palmisano, G, Giovanna, G, Fernandez, G, Steingel, G, Zhang, G, Choi, G, Chen, H, Hirose, H, Kayano, H, Ulgur, H, Impellizzeri, H, Ariola, H, Liu, H, Medina, H, Miyauchi, H, Takahashi, H, Hayashi, H, Ishikawa, H, Ishida, H, De Vries, H, Ulman, H, Kon, H, Ota, H, Akamatsu, H, Tamagawa, H, Shoji, H, Egi, H, Matsubara, H, Miki, H, Elfeki, H, Lin, H, Giani, I, Caravaca-Garcia, I, Takemasa, I, Angriman, I, Negoi, I, Volkova, I, Russo, I, Kronberger, I, Shageev, I, Aydin, I, Mora Guzman, I, Novak, I, Giuliano, I, Rachmuth, J, Ngu, J, Glasbey, J, Stoot, J, Zatecky, J, Melenhorst, J, Van Der Wal, J, Leijtens, J, Bogach, J, Elliott, J, De Wilt, J, Han, J, Cui, J, Liu, J, Khan, J, Wirawan, J, Zhang, J, Manyari, J, Doerner, J, Bock, J, Konsten, J, Castro, J, Grobas, J, Pereira, J, Juloski, J, Laina, J, Solorzano, J, Lopez, J, Li, J, Watanabe, J, Kwak, J, Hasegawa, J, Hiro, J, Sergey, K, Zhang, K, Nagahori, K, Martinez, K, Tokuhara, K, Danno, K, Uehara, K, Yoshimatsu, K, Ehara, K, Ueda, K, Suda, K, Yamamoto, K, Ishimaru, K, Kimura, K, Hirata, K, Deen, K, Imaizumi, K, Yamada, J, Tanakura, K, Rida, K, Sugimoto, K, Kotaro, K, Shi, K, Okabayashi, K, Hida, K, Kataoka, K, Hongo, K, Xia, K, Tseng, L, Reime, L, Lorenzon, L, Ruano, L, Zhou, L, De Nes, L, Brandariz, L, Morini, L, Petagna, L, Ripamonti, L, Martinez, L, Pio, L, Sacco, L, Carvalho, L, Zorcolo, L, Perez-Sanchez, L, Esparza, L, Aguilar, L, Garner, M, Sugimoto, M, Nagashima, M, Shiozawa, M, Simone, M, Ferrer-Marquez, M, Carvalho, M, Alifano, M, Arganini, M, Calussi, M, Catarci, M, Allaix, M, Forlin, M, Milone, M, Paci, M, Fodor, M, Antipova, M, Martos, M, Giuffrida, M, Tabernilla, M, Quiros, M, Lemma, M, Correo, M, Malowiecka, M, Bellomo, M, Fernandez, M, Socias, M, Rizk, M, Aurora, M, Antolinez, M, Ninkovic, M, De Roos, M, Lara, M, Agustin, M, Cuadrado, M, Pascual, M, Lemmerer, M, Carlos, R, Okamoto, M, Miyo, M, Inomata, M, Ikenaga, M, Tsujie, M, Yasuno, M, Kotake, M, Sato, M, Yasui, M, Lavazza, M, Rottoli, M, Zuin, M, Zuluaga, M, Cervellera, M, Cesari, M, Zizzo, M, Garino, M, Ghirardi, M, Montuori, M, Podda, M, Santarelli, M, Koc, M, Baini, M, Manigrasso, M, Zuolo, M, Cunha, M, Misca, M, Slavchev, M, Danilov, M, Shigaev, M, Martens, M, Kobayashi, M, Ren, M, Ishizuka, M, Hassan, M, Siblini, M, Sahloul, M, Keramati, M, Karunakaran, M, Markel, M, Majeed, M, Younis, M, Akin, M, Laraibe, M, Derebey, M, Kendirci, M, Fukunaga, M, Matsubara, N, Ordaz, N, Samalavicius, N, Keeratibharat, N, de Angelis, N, Gica, N, Mariani, N, Ramino, N, Falco, N, Smart, N, De Korte, N, Kok, N, Jamieson, N, Aberyasev, N, Bruklich, N, Ichikawa, N, Miyoshi, N, De Palma, N, Figueiredo, N, Torrecilla, N, Dybov, O, Yudin, O, Crepin, O, Gomez, O, Sert, O, Lominchar, P, Menendez, P, De Nardi, P, Tejedor, P, Jordan, P, Tan, P, Marsanic, P, Natalya, P, Banos, P, Rebasa, P, Neary, P, Tanis, P, Giustacchini, P, Anoldo, P, Concejo, P, Cao, P, Chandrasinghe, P, Abeyratne, P, Wang, Q, Klicks, R, Riquelme, R, Galli, R, Gianesini, R, Moorjani, R, Deshpande, R, Gorter, R, Ledesma, R, Ruslan, R, Chhabra, R, Talreja-Pelaez, R, Suzuki, R, Balestri, R, Rosati, R, Kiblawi, R, Martins, R, Angelico, R, Tutino, R, Persiani, R, Pollastri, R, Lopez, R, Perez, R, Hompes, R, Lukanin, R, Roser Termes Serra, R, Brunaccino, R, Nakanishi, R, Stefan, S, Hernandez, S, Di Carlo, S, Ingallinella, S, Domoto, S, Ikeda, S, Mikalauskas, S, Kim, S, Mantova, S, Barbuta, S, Li, S, Yamaguchi, S, Yamagishi, S, Homma, S, Tsujinaka, S, Yoshioka, S, Mori, S, Tewari, S, Rayman, S, Horiuchi, S, Matoba, S, Morita, S, Yaman, S, Vigna, S, Testa, S, Ng, S, Deidda, S, Cicconi, S, Di Maria, S, Sibio, S, Ersoz, S, Pejkova, S, Altarifi, S, He, S, Malakorn, S, Meindert, S, Sumikawa, S, Parmar, S, Uranitsch, S, D'Ugo, S, Giuliani, S, Breukink, S, Lee, S, Hata, T, Ishikawa, T, Akiyoshi, T, Azuma, T, Kobatake, T, Fukuzaki, T, Aiyama, T, Yamada, T, Garmanova, T, Gomez-Sanchez, T, Yamaguchi, T, Flores, T, Usub, T, Tsuruma, T, Shimizu, T, Hristov, T, Van Loon, T, Funakoshi, T, Manzia, T, Kiyomatsu, T, Katayama, T, Kazuhito, U, Elmore, U, Grossi, U, Truchalev, V, Rodriguez, V, Testa, V, Tonini, V, Celentano, V, Bettencourt, V, Mammadov, V, Leyva, V, Mariscal, V, Seid, V, Klemann, V, Turrado-Rodriguez, V, Papagni, V, Vento, V, Frering, V, Vigorita, V, Petrove, V, Lyadov, V, Fu, W, Mi, W, Jeong, W, Leclercq, W, De Sousa, X, Zhao, X, Li, X, Wang, X, Yang, X, Zhang, X, Dong, Y, Erushevich, Y, Takii, Y, Sumi, Y, Loli, Y, Yifat, Y, Shimada, Y, Nabeya, Y, Ide, Y, Wu, Y, Tsukada, Y, Miyamoto, Y, Toiyama, Y, Fujie, Y, Kaneko, Y, Mokutani, Y, Fujii, Y, Kanemitsu, Y, Medkova, Y, Chen, Y, Ruiz, Y, Kinugasa, Y, Sow, Z, Razzaq, Z, Wang, Z, Liu, Z, Han, Z, Tai, Z, Lai, Z, Ng, Z, and Dambrauskas, Z
Subjects: 2019-20 coronavirus outbreak, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), covid-19, pandemic, surgery, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Settore MED/18 - CHIRURGIA GENERALE, MEDLINE, COVID-19. Global surgery, Asymptomatic, COVID-19, Critical Pathways, Cross Infection, Cross-Sectional Studies, Health Care Surveys, Humans, Pandemics, Postoperative Complications, SARS-CoV-2, Surgical Procedures, Operative, Asymptomatic Infections, COVID-19, Critical Pathways, Cross Infection, Cross-Sectional Studies, Health Care Surveys, Humans, Pandemics, Postoperative Complications, SARS-CoV-2, Surgical Procedures, Operative, Asymptomatic Infections, NO, surgery, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Pandemic, Correspondence, medicine, LS7_4, COVID, Surgical Procedures, Critical pathways, business.industry, pandemic, Surgical procedures, Operative, Settore MED/18, covid 19, surgical practice, COVID-19 - surgery, Emergency medicine, medicine.symptom, business
Abstract: The rapid spread of COVID-19 has changed the global surgical care. Patients infected with COVID-19 may present without typical symptoms, and such asymptomatic patients may potentially trigger in-hospital outbreaks by transmitting the disease to health care providers and other hospitalized patients. Further, asymptomatic COVID-19 patients have worse postop- erative outcomes with an unexpectedly high morbidity and mortality, reaching 20⋅5 per cent deaths. However, we do not have objective global data on this issue. In an attempt to clarify the current global surgical practice under the COVID-19 pandemic particularly focusing on the preoperative screening of asymptomatic COVID-19 patients, we conducted a cross-sectional online survey on surgical practice. The survey was administered to surgeons worldwide through international surgical societies, social media and personal contacts dur- ing 2 April to 8 April. The results were analyzed by country’s cumulative deaths number by 8 April, 2020 (high risk, >5000; intermediate risk, 100-5000; low risk
Published: 2020

9. Surgeons' fear of getting infected by COVID19: A global survey

Author: An, Y., Bellato, V., Konishi, T., Pellino, G., Sensi, B., Siragusa, L., Franceschilli, M., Sica, G. S., Kefleyesus, A., Hoofwijk, A. G. M., Eldaly, A. S., Gonzalez, A., Jawad, A., Jooma, A., Hafez, A. M., Rubio, A. V., Landaluce-Olavarria, A., Wu, A., Nagatsu, A., Inoue, A., Kanamoto, A., Ouchi, A., El-Hussuna, A., Vazquez-Melero, A., Wolthuis, A. M., Peral, A. M., Lozano, A. C., Efremov, A., Ryasantsev, A. V., Giorgio, A. D., Parente, A., Tamburrini, A., Alo, A., Forero-Torres, A., Vahrmeijer, A. L., Varabei, A., Hinojosa, S., Balkan, A. Z. A., Frontali, A., Oleg, A., Soler-Silva, A., Makni, A., Andre, A., Cabrera, A. M. G., Fernandez, A. M. G., Minaya-Bravo, A. M., Rodriguez-Sanchez, A., Musina, A. -M., Pangeni, A., Zolotko, A., Tonoyan, A., Balla, A., Belli, A., Cavallaro, A., Chierici, A., Divizia, A., Bucci, A. F., Salido, A. J., Morini, A., Muratore, A., Vignali, A., Chitul, A., Sebastian, D. A., Pcolkins, A., Shchegolev, A., Hollenbeck, A., Wisneski, A., Iossa, A., D'Amore, A., Hunter, A., Hesketh, A. J., Brocca, A. L., Spinelli, A., Caires, A., D'Alessandro, A., Correo, A. F. S. L., Macri, A., Navarro-Sanchez, A., Pronk, A., Akunc, A., Mehri, A., Pelta, A., Papadopoulos, A., Kechagias, A., Rashid, A., Ramazanov, A., Chandio, A., Kohyama, A., Nishimura, A., Ohkawa, A., Dulskas, A., Jamal, A., Mariani, A., Unal, A. G., Karagoz, A., Ozkan, B. B., Salih, B., Gulcu, B., Pessia, B., Martin-Perez, B., Ielpo, B., Tulelli, B., Yang, B., Mhamed, B., Murphy, B., Pirozzi, B. M., Langenhoff, B., Belevi, B., Guney, B., Ng, C., Rueda, C., Roxburgh, C. S., Feo, C. V., Ferrari, C., Gazia, C., Pratesi, C., Ratto, C., Santacruz, C. C., Arroyave, C. R. M., Macias, C., Fernandez, C. G., Fernandez, C. C., Curtis-Martinez, C., Fortmann, C., Kim, C., Galeano, C. U., Barroso, C., Baldi, C., Foppa, C., Formisano, C., Li, C., Ding, C., Wang, C., Iacusso, C., Yang, C., Pizzera, C., Skias, C., Chouliras, C., Liakos, C., Matsuda, C., C. -Y., Wu, Ozaslan, C., Tanda, C., Tommaso, C. M., Dagorno, C., Ramos, C. P. A., Arcudi, C., Coco, C., Morales, C. M., Ali, M. Z., De Azevedo, C. T. M., Lozano, C. C., Sala, C., Leo, C. A., Scarpa, C. R., Ferro, C. V., Fernandez, C. M., Morales-Garcia, D., Nakano, D., Cristian, D., Hechtl, D., Canovas, D. T., Calabrese, D., Rega, D., Ferraro, D., Morezzi, D., Sommacale, D., Brogden, D., Miskovic, D., Merlini, D., Pertile, D., Coniglio, D., Zhu, D., Wu, D., Coletta, D., Rubio, D. R., Sasia, D., Fillipov, D., Russiello, D., Dardanov, D., Consten, E. C. J., Smolskas, E., Muttillo, E. M., Jones, E., Sunami, E., Etienne, E. -H., Chalkiadaki, E., Giacomelli, E., Karbovnichaya, E., Ruiz-Ucar, E., Guaitoli, E., Samadov, E., Jovine, E., Treppiedi, E., Vaterlini, E. M., Zambaiti, E., Moggia, E., Coetzee, E., Chisari, E., D'Errico, E., Ciofic, E., Pena, E., Kurt, E., Balik, E., Gunay, E., Sivrikoz, E., Andolfi, E., Araimo, E., Lucci, E., Opocher, E., Pinotti, E., Rubino, E., Reyhan, E., Mazzotta, E., Navarro, E. B., El-Helou, E., Licardie-Bolanos, E., Porto, E. I., Contreras, E., Boerma, E. -J., Cianchi, F., Marino, F., Uggeri, F., Han, F., Calculli, F., Falaschi, F., Ghignone, F., Perrone, F., Borghi, F., Garcia, F., Agresta, F., Cananzi, F. C. M., Mendoza-Moreno, F., Cengiz, F., Almeida, F. M., Baracchi, F., Carannante, F., Torre, F. L., Fernandes, F., Friedmacher, F., Grama, F., Carissimi, F., Pecchini, F., Bianco, F., Colombo, F., Ferrara, F., Litta, F., Carrano, F. M., Martignoni, F., Tasselli, F. M., Milone, F., Pata, F., Sammartino, F., Zambianchi, F., Barragan, F., Herrero, F., Schlottmann, F., Den Boer, F. C., Pfeffer, F., Fujita, F., Navarra, G., Herrera-Almario, G., Pozzo, G., Capolupo, G. T., Van Ramshorst, G. H., Liscia, G., Gallo, G., Asawa, G., Wang, G., Raiyani, G., Beets, G., Naval, G. S., Jin, G., Chang, G. J., Saakian, G., Kahane, G., Borroni, G., Secco, G. L., Baiocchi, G. L., Baronio, G., Pagano, G., Pattacini, G. C., Lisi, G., Milito, G., Sinibaldi, G., Serrao, G., Bagaglini, G., Sarro, G., Brisinda, G., Candilio, G., Mangiameli, G., Giuliani, G., Martin-Martin, G. P., Bodzin, G., Leon, G., Mackay, G., Vasil, G., Palmisano, G., Giovanna, G. M., Fernandez, G. C., Steingel, G. B., Zhang, G., Choi, G. S., Chen, H., Hirose, H., Kayano, H., Ulgur, H. S., Impellizzeri, H., Ariola, H., Liu, H., Medina, H., Miyauchi, H., Takahashi, H., Hayashi, H., Ishikawa, H., Ishida, H., De Vries, H., Ulman, H., Kon, H., Ota, H., Akamatsu, H., Tamagawa, H., Shoji, H., Egi, H., Matsubara, H., Miki, H., Elfeki, H., Lin, H. -H., Giani, I., Caravaca-Garcia, I., Takemasa, I., Angriman, I., Negoi, I., Volkova, I., Russo, I., Kronberger, I. E., Shageev, I., Aydin, I., Guzman, I. M., Novak, I., Giuliano, I., Rachmuth, J., Ngu, J. C. -Y., Glasbey, J., Stoot, J., Zatecky, J., Melenhorst, J., Van Der Wal, J. B. C., Leijtens, J., Bogach, J., Elliott, J., De Wilt, J. H. W., Han, J., Cui, J., Liu, J., Khan, J., Wirawan, J. P., Zhang, J., Manyari, J. D. O., Doerner, J., Bock, J., Konsten, J., Castro, J. M., Grobas, J. P., Pinto, J. P., Juloski, J., Laina, J. L. B., Solorzano, J. J., Lopez, J. R. G., Li, J., Watanabe, J., Kwak, J. -M., Hasegawa, J., Hiro, J., Sergey, K., Zhang, K., Nagahori, K., Martinez, K., Tokuhara, K., Danno, K., Uehara, K., Yoshimatsu, K., Ehara, K., Ueda, K., Suda, K., Yamamoto, K., Ishimaru, K., Kimura, K., Hirata, K., Deen, K., Imaizumi, K., Yamada, J., Tanakura, K., Rida, K., Sugimoto, K., Kotaro, K., Shi, K., Okabayashi, K., Hida, K., Kataoka, K., Hongo, K., Xia, K., Tseng, L., Reime, L., Lorenzon, L., Ruano, L. M., Zhou, L., De Nes, L., Brandariz, L., Morini, L., Petagna, L., Ripamonti, L., Martinez, L. H., Pio, L., Sacco, L., Carvalho, L., Zorcolo, L., Perez-Sanchez, L. E., Esparza, L. H. R., Aguilar, L. T., Garner, M., Sugimoto, M., Nagashima, M., Shiozawa, M., Simone, M., Ferrer-Marquez, M., Carvalho, M., Alifano, M., Arganini, M., Calussi, M., Catarci, M., Allaix, M. E., Forlin, M., Milone, M., Paci, M., Fodor, M., Antipova, M., Martos, M. B., Giuffrida, M. C., Tabernilla, M. D., Quiros, M. J. A., Lemma, M., Correo, M. L. R. D., Malowiecka, M., Bellomo, M. P., Fernandez, M. R., Socias, M., Rizk, M., Aurora, M., Antolinez, M. A., Ninkovic, M., Giuffrida, M., Leeuwenburgh, M. M. N., De Roos, M. A. J., Lara, M. C., Agustin, M. C., Cuadrado, M., Pascual, M., Lemmerer, M., Carlos, R., Okamoto, M., Miyo, M., Inomata, M., Ikenaga, M., Tsujie, M., Yasuno, M., Kotake, M., Sato, M., Yasui, M., Lavazza, M., Rottoli, M., Zuin, M., Zuluaga, M., Cervellera, M., Cesari, M., Zizzo, M., Garino, M., Ghirardi, M., Montuori, M., Podda, M., Santarelli, M., Koc, M. A., Baini, M., De Cillia, M., Campanelli, M., De Rosa, M., Manigrasso, M., Zuolo, M., Cunha, M. F., Misca, M., Slavchev, M., Danilov, M., Shigaev, M., Martens, M., Kobayashi, M., Ren, M., Ishizuka, M., Hassan, M. M., Siblini, M., Sahloul, M., Keramati, M. R., Karunakaran, M., Markel, M., Majeed, M., Younis, M. U., Akin, M. I., Laraibe, M., Derebey, M., Kendirci, M., Fukunaga, M., Matsubara, N., Ordaz, N. E. C., Samalavicius, N. E., Keeratibharat, N., De Angelis, N., Gica, N., Mariani, N. M., Ramino, N., Falco, N., Smart, N., De Korte, N., Kok, N. F. M., Jamieson, N. B., Aberyasev, N., Bruklich, N., Ichikawa, N., Miyoshi, N., De Palma, N., Figueiredo, N., Torrecilla, N. O., Dybov, O. G., Yudin, O., Crepin, O., Gomez, O., Sert, O. Z., Lominchar, P. L., Menendez, P., De Nardi, P., Tejedor, P., Jordan, P., Tan, P., Marsanic, P., Natalya, P., Banos, P. P., Rebasa, P., Neary, P. M., Tanis, P., Giustacchini, P., Anoldo, P., Concejo, P., Cao, P., Chandrasinghe, P., Abeyratne, P., Wang, Q., Klicks, R. J., Mukai, R., Riquelme, R. F., De Luca, R., Galli, R., Gianesini, R., Moorjani, R. G., Deshpande, R. K., Gorter, R., Ledesma, R. L., Ruslan, R., Chhabra, R., Talreja-Pelaez, R., Suzuki, R., Balestri, R., Rosati, R., Kiblawi, R., Martins, R., Angelico, R., Tutino, R., Persiani, R., Pollastri, R., Lopez, R. G., Perez, R. O., Hompes, R., Lukanin, R., Roser Termes Serra, R., Brunaccino, R., Nakanishi, R., Stefan, S., Hernandez, S. P. S., Carlo, S. D., Ingallinella, S., Domoto, S., Ikeda, S., Mikalauskas, S., Kim, S. H., Mantova, S., Barbuta, S., Li, S., Yamaguchi, S., Yamagishi, S., Homma, S., Tsujinaka, S., Yoshioka, S., Mori, S., Tewari, S., Rayman, S., Horiuchi, S., Matoba, S., Morita, S., Yaman, S., Vigna, S., Testa, S., Ng, S., Deidda, S., Cicconi, S., Maria, S. D., Sibio, S., Ersoz, S., Pejkova, S., Altarifi, S., He, S., Malakorn, S., Meindert, S., Sumikawa, S., Parmar, S., Uranitsch, S., D'Ugo, S., Giuliani, S., Breukink, S., Lee, S. -H., Hata, T., Ishikawa, T., Akiyoshi, T., Azuma, T., Kobatake, T., Fukuzaki, T., Aiyama, T., Yamada, T., Garmanova, T., Gomez-Sanchez, T., Yamaguchi, T., De Jesus Flores, T., Usub, T., Tsuruma, T., Shimizu, T., Hristov, T. G., Van Loon, T., Funakoshi, T., Manzia, T. M., Kiyomatsu, T., Katayama, T., Akagi, T., Mizushima, T., Kazuhito, U., Elmore, U., Grossi, U., Truchalev, V. A., Rodriguez, V. S., Testa, V., Tonini, V., Celentano, V., Nekoval, V. M., Bettencourt, V., Mammadov, V., Leyva, V. A. G., Mariscal, V. G. O., Seid, V. E., Klemann, V., Turrado-Rodriguez, V., Papagni, V., Vento, V., Frering, V., Vigorita, V., Petrove, V. V., Lyadov, V., Fu, W., Mi, W., Jeong, W. K., Leclercq, W. K. G., De Sousa, X., Zhao, X., Li, X., Wang, X., Yang, X., Zhang, X., Zhen, Y., Dong, Y., Erushevich, Y., Takii, Y., Sumi, Y., Loli, Y. T., Yifat, Y. L., Shimada, Y., Nabeya, Y., Ide, Y., Wu, Y., Tsukada, Y., Miyamoto, Y., Toiyama, Y., Fujie, Y., Kaneko, Y., Mokutani, Y., Fujii, Y., Kanemitsu, Y., Medkova, Y., Chen, Y., Ruiz, Y. G., Kinugasa, Y., Sow, Z., Razzaq, Z., Wang, Z., Liu, Z., Han, Z., Tai, Z., Lai, Z., Z. Q., Ng, Dambrauskas, Z., An Y., Bellato V., Konishi T., Pellino G., Sensi B., Siragusa L., Franceschilli M., Sica G.S., Kefleyesus A., Hoofwijk A.G.M., Eldaly A.S., Gonzalez A., Jawad A., Jooma A., Hafez A.M., Rubio A.V., Landaluce-Olavarria A., Wu A., Nagatsu A., Inoue A., Kanamoto A., Ouchi A., El-Hussuna A., Vazquez-Melero A., Wolthuis A.M., Peral A.M., Lozano A.C., Efremov A., Ryasantsev A.V., Di Giorgio A., Parente A., Tamburrini A., Alo A., Forero-Torres A., Vahrmeijer A.L., Varabei A., Hinojosa S., Balkan A.Z.A., Frontali A., Oleg A., Soler-Silva A., Makni A., Andre A., Cabrera A.M.G., Fernandez A.M.G., Minaya-Bravo A.M., Rodriguez-Sanchez A., Musina A.-M., Pangeni A., Zolotko A., Tonoyan A., Balla A., Belli A., Cavallaro A., Chierici A., Divizia A., Bucci A.F., Salido A.J., Morini A., Muratore A., Vignali A., Chitul A., Sebastian D.A., Pcolkins A., Shchegolev A., Hollenbeck A., Wisneski A., Iossa A., D'Amore A., Hunter A., Hesketh A.J., La Brocca A., Spinelli A., Caires A., D'Alessandro A., Correo A.F.S.L., Macri A., Navarro-Sanchez A., Pronk A., Akunc A., Mehri A., Pelta A., Papadopoulos A., Kechagias A., Rashid A., Ramazanov A., Chandio A., Kohyama A., Nishimura A., Ohkawa A., Dulskas A., Jamal A., Mariani A., Unal A.G., Karagoz A., Ozkan B.B., Salih B., Gulcu B., Pessia B., Martin-Perez B., Ielpo B., Tulelli B., Yang B., Mhamed B., Murphy B., Pirozzi B.M., Langenhoff B., Belevi B., Guney B., Ng C., Rueda C., Roxburgh C.S., Feo C.V., Ferrari C., Gazia C., Pratesi C., Ratto C., Santacruz C.C., Arroyave C.R.M., Macias C., Fernandez C.G., Fernandez C.C., Curtis-Martinez C., Fortmann C., Kim C., Galeano C.U., Barroso C., Baldi C., Foppa C., Formisano C., Li C., Ding C., Wang C., Iacusso C., Yang C., Pizzera C., Skias C., Chouliras C., Liakos C., Matsuda C., Wu C.-Y., Ozaslan C., Tanda C., Tommaso C.M., Dagorno C., Ramos C.P.A., Arcudi C., Coco C., Morales C.M., Ali M.Z., Lozano C.C., Sala C., Leo C.A., Scarpa C.R., Ferro C.V., Fernandez C.M., Morales-Garcia D., Nakano D., Cristian D., Hechtl D., Canovas D.T., Calabrese D., Rega D., Ferraro D., Morezzi D., Sommacale D., Brogden D., Miskovic D., Merlini D., Pertile D., Coniglio D., Zhu D., Wu D., Coletta D., Rubio D.R., Sasia D., Fillipov D., Russiello D., Dardanov D., Consten E.C.J., Smolskas E., Muttillo E.M., Jones E., Sunami E., Etienne E.-H., Chalkiadaki E., Giacomelli E., Karbovnichaya E., Ruiz-Ucar E., Guaitoli E., Samadov E., Jovine E., Treppiedi E., Vaterlini E.M., Zambaiti E., Moggia E., Coetzee E., Chisari E., D'Errico E., Ciofic E., Pena E., Kurt E., Balik E., Gunay E., Sivrikoz E., Andolfi E., Araimo E., Lucci E., Opocher E., Pinotti E., Rubino E., Reyhan E., Mazzotta E., Navarro E.B., El-Helou E., Licardie-Bolanos E., Porto E.I., Contreras E., Boerma E.-J., Cianchi F., Marino F., Uggeri F., Han F., Calculli F., Falaschi F., Ghignone F., Perrone F., Borghi F., Garcia F., Agresta F., Cananzi F.C.M., Mendoza-Moreno F., Cengiz F., Almeida F.M., Baracchi F., Carannante F., La Torre F., Fernandes F., Friedmacher F., Grama F., Carissimi F., Pecchini F., Bianco F., Colombo F., Ferrara F., Litta F., Carrano F.M., Martignoni F., Tasselli F.M., Milone F., Pata F., Sammartino F., Zambianchi F., Barragan F., Herrero F., Schlottmann F., Den Boer F.C., Pfeffer F., Fujita F., Navarra G., Herrera-Almario G., Pozzo G., Capolupo G.T., Van Ramshorst G.H., Liscia G., Gallo G., Asawa G., Wang G., Raiyani G., Beets G., Naval G.S., Jin G., Chang G.J., Saakian G., Kahane G., Borroni G., Secco G.L., Baiocchi G.L., Baronio G., Pagano G., Pattacini G.C., Lisi G., Milito G., Sinibaldi G., Serrao G., Bagaglini G., Sarro G., Brisinda G., Candilio G., Mangiameli G., Giuliani G., Martin-Martin G.P., Bodzin G., Leon G., Mackay G., Vasil G., Palmisano G., Giovanna G.M., Fernandez G.C., Steingel G.B., Zhang G., Choi G.S., Chen H., Hirose H., Kayano H., Ulgur H.S., Impellizzeri H., Ariola H., Liu H., Medina H., Miyauchi H., Takahashi H., Hayashi H., Ishikawa H., Ishida H., De Vries H., Ulman H., Kon H., Ota H., Akamatsu H., Tamagawa H., Shoji H., Egi H., Matsubara H., Miki H., Elfeki H., Lin H.-H., Giani I., Caravaca-Garcia I., Takemasa I., Angriman I., Negoi I., Volkova I., Russo I., Kronberger I.E., Shageev I., Aydin I., Mora Guzman I., Novak I., Giuliano I., Rachmuth J., Ngu J.C.-Y., Glasbey J., Stoot J., Zatecky J., Melenhorst J., Van Der Wal J.B.C., Leijtens J., Bogach J., Elliott J., De Wilt J.H.W., Han J., Cui J., Liu J., Khan J., Wirawan J.P., Zhang J., Manyari J.D.O., Doerner J., Bock J., Konsten J., Castro J.M., Grobas J.P., Pereira J., Juloski J., Laina J.L.B., Solorzano J.J., Lopez J.R.G., Li J., Watanabe J., Kwak J.-M., Hasegawa J., Hiro J., Sergey K., Zhang K., Nagahori K., Martinez K., Tokuhara K., Danno K., Uehara K., Yoshimatsu K., Ehara K., Ueda K., Suda K., Yamamoto K., Ishimaru K., Kimura K., Hirata K., Deen K., Imaizumi K., Yamada J., Tanakura K., Rida K., Sugimoto K., Kotaro K., Shi K., Okabayashi K., Hida K., Kataoka K., Hongo K., Xia K., Tseng L., Reime L., Lorenzon L., Ruano L.M., Zhou L., De Nes L., Brandariz L., Morini L., Petagna L., Ripamonti L., Martinez L.H., Pio L., Sacco L., Carvalho L., Zorcolo L., Perez-Sanchez L.E., Esparza L.H.R., Aguilar L.T., Garner M., Sugimoto M., Nagashima M., Shiozawa M., Simone M., Ferrer-Marquez M., Carvalho M., Alifano M., Arganini M., Calussi M., Catarci M., Allaix M.E., Forlin M., Milone M., Paci M., Fodor M., Antipova M., Martos M.B., Giuffrida M.C., Tabernilla M.D., Quiros M.J.A., Lemma M., Correo M.L.R.D., Malowiecka M., Bellomo M.P., Fernandez M.R., Socias M., Rizk M., Aurora M., Antolinez M.A., Ninkovic M., Giuffrida M., De Roos M.A.J., Lara M.C., Agustin M.C., Cuadrado M., Pascual M., Lemmerer M., Carlos R., Okamoto M., Miyo M., Inomata M., Ikenaga M., Tsujie M., Yasuno M., Kotake M., Sato M., Yasui M., Lavazza M., Rottoli M., Zuin M., Zuluaga M., Cervellera M., Cesari M., Zizzo M., Garino M., Ghirardi M., Montuori M., Podda M., Santarelli M., Koc M.A., Baini M., Campanelli M., Manigrasso M., Zuolo M., Cunha M.F., Misca M., Slavchev M., Danilov M., Shigaev M., Martens M., Kobayashi M., Ren M., Ishizuka M., Hassan M.M., Siblini M., Sahloul M., Keramati M.R., Karunakaran M., Markel M., Majeed M., Younis M.U., Akin M.I., Laraibe M., Derebey M., Kendirci M., Fukunaga M., Matsubara N., Ordaz N.E.C., Samalavicius N.E., Keeratibharat N., de Angelis N., Gica N., Mariani N.M., Ramino N., Falco N., Smart N., De Korte N., Kok N.F.M., Jamieson N.B., Aberyasev N., Bruklich N., Ichikawa N., Miyoshi N., De Palma N., Figueiredo N., Torrecilla N.O., Dybov O.G., Yudin O., Crepin O., Gomez O., Sert O.Z., Lominchar P.L., Menendez P., De Nardi P., Tejedor P., Jordan P., Tan P., Marsanic P., Natalya P., Banos P.P., Rebasa P., Neary P.M., Tanis P., Giustacchini P., Anoldo P., Concejo P., Cao P., Chandrasinghe P., Abeyratne P., Wang Q., Klicks R.J., Riquelme R.F., Galli R., Gianesini R., Moorjani R.G., Deshpande R.K., Gorter R., Ledesma R.L., Ruslan R., Chhabra R., Talreja-Pelaez R., Suzuki R., Balestri R., Rosati R., Kiblawi R., Martins R., Angelico R., Tutino R., Persiani R., Pollastri R., Lopez R.G., Perez R.O., Hompes R., Lukanin R., Roser Termes Serra R., Brunaccino R., Nakanishi R., Stefan S., Hernandez S.P.S., Di Carlo S., Ingallinella S., Domoto S., Ikeda S., Mikalauskas S., Kim S.H., Mantova S., Barbuta S., Li S., Yamaguchi S., Yamagishi S., Homma S., Tsujinaka S., Yoshioka S., Mori S., Tewari S., Rayman S., Horiuchi S., Matoba S., Morita S., Yaman S., Vigna S., Testa S., Ng S., Deidda S., Cicconi S., Di Maria S., Sibio S., Ersoz S., Pejkova S., Altarifi S., He S., Malakorn S., Meindert S., Sumikawa S., Parmar S., Uranitsch S., D'ugo S., Giuliani S., Breukink S., Lee S.-H., Hata T., Ishikawa T., Akiyoshi T., Azuma T., Kobatake T., Fukuzaki T., Aiyama T., Yamada T., Garmanova T., Gomez-Sanchez T., Yamaguchi T., Flores T.D.J., Usub T., Tsuruma T., Shimizu T., Hristov T.G., Van Loon T., Funakoshi T., Manzia T.M., Kiyomatsu T., Katayama T., Kazuhito U., Elmore U., Grossi U., Truchalev V.A., Rodriguez V.S., Testa V., Tonini V., Celentano V., Bettencourt V., Mammadov V., Leyva V.A.G., Mariscal V.G.O., Seid V.E., Klemann V., Turrado-Rodriguez V., Papagni V., Vento V., Frering V., Vigorita V., Petrove V.V., Lyadov V., Fu W., Mi W., Jeong W.K., Leclercq W.K.G., De Sousa X., Zhao X., Li X., Wang X., Yang X., Zhang X., Dong Y., Erushevich Y., Takii Y., Sumi Y., Loli Y.T., Yifat Y.L., Shimada Y., Nabeya Y., Ide Y., Wu Y., Tsukada Y., Miyamoto Y., Toiyama Y., Fujie Y., Kaneko Y., Mokutani Y., Fujii Y., Kanemitsu Y., Medkova Y., Chen Y., Ruiz Y.G., Kinugasa Y., Sow Z., Razzaq Z., Wang Z., Liu Z., Han Z., Tai Z., Lai Z., Ng Z.Q., Dambrauskas Z., Robotics and image-guided minimally-invasive surgery (ROBOTICS), Center of Experimental and Molecular Medicine, Graduate School, ACS - Pulmonary hypertension & thrombosis, AII - Infectious diseases, Surgery, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Surgery, ARD - Amsterdam Reproduction and Development, An, Y., Bellato, V., Konishi, T., Pellino, G., Sensi, B., Siragusa, L., Franceschilli, M., Sica, G. S., Kefleyesus, A., Hoofwijk, A. G. M., Eldaly, A. S., Gonzalez, A., Jawad, A., Jooma, A., Hafez, A. M., Rubio, A. V., Landaluce-Olavarria, A., Wu, A., Nagatsu, A., Inoue, A., Kanamoto, A., Ouchi, A., El-Hussuna, A., Vazquez-Melero, A., Wolthuis, A. M., Peral, A. M., Lozano, A. C., Efremov, A., Ryasantsev, A. V., Di Giorgio, A., Parente, A., Tamburrini, A., Alo, A., Forero-Torres, A., Vahrmeijer, A. L., Varabei, A., Hinojosa, S., Balkan, A. Z. A., Frontali, A., Oleg, A., Soler-Silva, A., Makni, A., Andre, A., Cabrera, A. M. G., Fernandez, A. M. G., Minaya-Bravo, A. M., Rodriguez-Sanchez, A., Musina, A. -M., Pangeni, A., Zolotko, A., Tonoyan, A., Balla, A., Belli, A., Cavallaro, A., Chierici, A., Divizia, A., Bucci, A. F., Salido, A. J., Morini, A., Muratore, A., Vignali, A., Chitul, A., Sebastian, D. A., Pcolkins, A., Shchegolev, A., Hollenbeck, A., Wisneski, A., Iossa, A., D'Amore, A., Hunter, A., Hesketh, A. J., La Brocca, A., Spinelli, A., Caires, A., D'Alessandro, A., Correo, A. F. S. L., Macri, A., Navarro-Sanchez, A., Pronk, A., Akunc, A., Mehri, A., Pelta, A., Papadopoulos, A., Kechagias, A., Rashid, A., Ramazanov, A., Chandio, A., Kohyama, A., Nishimura, A., Ohkawa, A., Dulskas, A., Jamal, A., Mariani, A., Unal, A. G., Karagoz, A., Ozkan, B. B., Salih, B., Gulcu, B., Pessia, B., Martin-Perez, B., Ielpo, B., Tulelli, B., Yang, B., Mhamed, B., Murphy, B., Pirozzi, B. M., Langenhoff, B., Belevi, B., Guney, B., Ng, C., Rueda, C., Roxburgh, C. S., Feo, C. V., Ferrari, C., Gazia, C., Pratesi, C., Ratto, C., Santacruz, C. C., Arroyave, C. R. M., Macias, C., Fernandez, C. G., Fernandez, C. C., Curtis-Martinez, C., Fortmann, C., Kim, C., Galeano, C. U., Barroso, C., Baldi, C., Foppa, C., Formisano, C., Li, C., Ding, C., Wang, C., Iacusso, C., Yang, C., Pizzera, C., Skias, C., Chouliras, C., Liakos, C., Matsuda, C., Wu, C. -Y., Ozaslan, C., Tanda, C., Tommaso, C. M., Dagorno, C., Ramos, C. P. A., Arcudi, C., Coco, C., Morales, C. M., Ali, M. Z., Lozano, C. C., Sala, C., Leo, C. A., Scarpa, C. R., Ferro, C. V., Fernandez, C. M., Morales-Garcia, D., Nakano, D., Cristian, D., Hechtl, D., Canovas, D. T., Calabrese, D., Rega, D., Ferraro, D., Morezzi, D., Sommacale, D., Brogden, D., Miskovic, D., Merlini, D., Pertile, D., Coniglio, D., Zhu, D., Wu, D., Coletta, D., Rubio, D. R., Sasia, D., Fillipov, D., Russiello, D., Dardanov, D., Consten, E. C. J., Smolskas, E., Muttillo, E. M., Jones, E., Sunami, E., Etienne, E. -H., Chalkiadaki, E., Giacomelli, E., Karbovnichaya, E., Ruiz-Ucar, E., Guaitoli, E., Samadov, E., Jovine, E., Treppiedi, E., Vaterlini, E. M., Zambaiti, E., Moggia, E., Coetzee, E., Chisari, E., D'Errico, E., Ciofic, E., Pena, E., Kurt, E., Balik, E., Gunay, E., Sivrikoz, E., Andolfi, E., Araimo, E., Lucci, E., Opocher, E., Pinotti, E., Rubino, E., Reyhan, E., Mazzotta, E., Navarro, E. B., El-Helou, E., Licardie-Bolanos, E., Porto, E. I., Contreras, E., Boerma, E. -J., Cianchi, F., Marino, F., Uggeri, F., Han, F., Calculli, F., Falaschi, F., Ghignone, F., Perrone, F., Borghi, F., Garcia, F., Agresta, F., Cananzi, F. C. M., Mendoza-Moreno, F., Cengiz, F., Almeida, F. M., Baracchi, F., Carannante, F., La Torre, F., Fernandes, F., Friedmacher, F., Grama, F., Carissimi, F., Pecchini, F., Bianco, F., Colombo, F., Ferrara, F., Litta, F., Carrano, F. M., Martignoni, F., Tasselli, F. M., Milone, F., Pata, F., Sammartino, F., Zambianchi, F., Barragan, F., Herrero, F., Schlottmann, F., Den Boer, F. C., Pfeffer, F., Fujita, F., Navarra, G., Herrera-Almario, G., Pozzo, G., Capolupo, G. T., Van Ramshorst, G. H., Liscia, G., Gallo, G., Asawa, G., Wang, G., Raiyani, G., Beets, G., Naval, G. S., Jin, G., Chang, G. J., Saakian, G., Kahane, G., Borroni, G., Secco, G. L., Baiocchi, G. L., Baronio, G., Pagano, G., Pattacini, G. C., Lisi, G., Milito, G., Sinibaldi, G., Serrao, G., Bagaglini, G., Sarro, G., Brisinda, G., Candilio, G., Mangiameli, G., Giuliani, G., Martin-Martin, G. P., Bodzin, G., Leon, G., Mackay, G., Vasil, G., Palmisano, G., Giovanna, G. M., Fernandez, G. C., Steingel, G. B., Zhang, G., Choi, G. S., Chen, H., Hirose, H., Kayano, H., Ulgur, H. S., Impellizzeri, H., Ariola, H., Liu, H., Medina, H., Miyauchi, H., Takahashi, H., Hayashi, H., Ishikawa, H., Ishida, H., De Vries, H., Ulman, H., Kon, H., Ota, H., Akamatsu, H., Tamagawa, H., Shoji, H., Egi, H., Matsubara, H., Miki, H., Elfeki, H., Lin, H. -H., Giani, I., Caravaca-Garcia, I., Takemasa, I., Angriman, I., Negoi, I., Volkova, I., Russo, I., Kronberger, I. E., Shageev, I., Aydin, I., Mora Guzman, I., Novak, I., Giuliano, I., Rachmuth, J., Ngu, J. C. -Y., Glasbey, J., Stoot, J., Zatecky, J., Melenhorst, J., Van Der Wal, J. B. C., Leijtens, J., Bogach, J., Elliott, J., De Wilt, J. H. W., Han, J., Cui, J., Liu, J., Khan, J., Wirawan, J. P., Zhang, J., Manyari, J. D. O., Doerner, J., Bock, J., Konsten, J., Castro, J. M., Grobas, J. P., Pereira, J., Juloski, J., Laina, J. L. B., Solorzano, J. J., Lopez, J. R. G., Li, J., Watanabe, J., Kwak, J. -M., Hasegawa, J., Hiro, J., Sergey, K., Zhang, K., Nagahori, K., Martinez, K., Tokuhara, K., Danno, K., Uehara, K., Yoshimatsu, K., Ehara, K., Ueda, K., Suda, K., Yamamoto, K., Ishimaru, K., Kimura, K., Hirata, K., Deen, K., Imaizumi, K., Yamada, J., Tanakura, K., Rida, K., Sugimoto, K., Kotaro, K., Shi, K., Okabayashi, K., Hida, K., Kataoka, K., Hongo, K., Xia, K., Tseng, L., Reime, L., Lorenzon, L., Ruano, L. M., Zhou, L., De Nes, L., Brandariz, L., Morini, L., Petagna, L., Ripamonti, L., Martinez, L. H., Pio, L., Sacco, L., Carvalho, L., Zorcolo, L., Perez-Sanchez, L. E., Esparza, L. H. R., Aguilar, L. T., Garner, M., Sugimoto, M., Nagashima, M., Shiozawa, M., Simone, M., Ferrer-Marquez, M., Carvalho, M., Alifano, M., Arganini, M., Calussi, M., Catarci, M., Allaix, M. E., Forlin, M., Milone, M., Paci, M., Fodor, M., Antipova, M., Martos, M. B., Giuffrida, M. C., Tabernilla, M. D., Quiros, M. J. A., Lemma, M., Correo, M. L. R. D., Malowiecka, M., Bellomo, M. P., Fernandez, M. R., Socias, M., Rizk, M., Aurora, M., Antolinez, M. A., Ninkovic, M., Giuffrida, M., De Roos, M. A. J., Lara, M. C., Agustin, M. C., Cuadrado, M., Pascual, M., Lemmerer, M., Carlos, R., Okamoto, M., Miyo, M., Inomata, M., Ikenaga, M., Tsujie, M., Yasuno, M., Kotake, M., Sato, M., Yasui, M., Lavazza, M., Rottoli, M., Zuin, M., Zuluaga, M., Cervellera, M., Cesari, M., Zizzo, M., Garino, M., Ghirardi, M., Montuori, M., Podda, M., Santarelli, M., Koc, M. A., Baini, M., Campanelli, M., Manigrasso, M., Zuolo, M., Cunha, M. F., Misca, M., Slavchev, M., Danilov, M., Shigaev, M., Martens, M., Kobayashi, M., Ren, M., Ishizuka, M., Hassan, M. M., Siblini, M., Sahloul, M., Keramati, M. R., Karunakaran, M., Markel, M., Majeed, M., Younis, M. U., Akin, M. I., Laraibe, M., Derebey, M., Kendirci, M., Fukunaga, M., Matsubara, N., Ordaz, N. E. C., Samalavicius, N. E., Keeratibharat, N., de Angelis, N., Gica, N., Mariani, N. M., Ramino, N., Falco, N., Smart, N., De Korte, N., Kok, N. F. M., Jamieson, N. B., Aberyasev, N., Bruklich, N., Ichikawa, N., Miyoshi, N., De Palma, N., Figueiredo, N., Torrecilla, N. O., Dybov, O. G., Yudin, O., Crepin, O., Gomez, O., Sert, O. Z., Lominchar, P. L., Menendez, P., De Nardi, P., Tejedor, P., Jordan, P., Tan, P., Marsanic, P., Natalya, P., Banos, P. P., Rebasa, P., Neary, P. M., Tanis, P., Giustacchini, P., Anoldo, P., Concejo, P., Cao, P., Chandrasinghe, P., Abeyratne, P., Wang, Q., Klicks, R. J., Riquelme, R. F., Galli, R., Gianesini, R., Moorjani, R. G., Deshpande, R. K., Gorter, R., Ledesma, R. L., Ruslan, R., Chhabra, R., Talreja-Pelaez, R., Suzuki, R., Balestri, R., Rosati, R., Kiblawi, R., Martins, R., Angelico, R., Tutino, R., Persiani, R., Pollastri, R., Lopez, R. G., Perez, R. O., Hompes, R., Lukanin, R., Roser Termes Serra, R., Brunaccino, R., Nakanishi, R., Stefan, S., Hernandez, S. P. S., Di Carlo, S., Ingallinella, S., Domoto, S., Ikeda, S., Mikalauskas, S., Kim, S. H., Mantova, S., Barbuta, S., Li, S., Yamaguchi, S., Yamagishi, S., Homma, S., Tsujinaka, S., Yoshioka, S., Mori, S., Tewari, S., Rayman, S., Horiuchi, S., Matoba, S., Morita, S., Yaman, S., Vigna, S., Testa, S., Ng, S., Deidda, S., Cicconi, S., Di Maria, S., Sibio, S., Ersoz, S., Pejkova, S., Altarifi, S., He, S., Malakorn, S., Meindert, S., Sumikawa, S., Parmar, S., Uranitsch, S., D'Ugo, S., Giuliani, S., Breukink, S., Lee, S. -H., Hata, T., Ishikawa, T., Akiyoshi, T., Azuma, T., Kobatake, T., Fukuzaki, T., Aiyama, T., Yamada, T., Garmanova, T., Gomez-Sanchez, T., Yamaguchi, T., Flores, T. D. J., Usub, T., Tsuruma, T., Shimizu, T., Hristov, T. G., Van Loon, T., Funakoshi, T., Manzia, T. M., Kiyomatsu, T., Katayama, T., Kazuhito, U., Elmore, U., Grossi, U., Truchalev, V. A., Rodriguez, V. S., Testa, V., Tonini, V., Celentano, V., Bettencourt, V., Mammadov, V., Leyva, V. A. G., Mariscal, V. G. O., Seid, V. E., Klemann, V., Turrado-Rodriguez, V., Papagni, V., Vento, V., Frering, V., Vigorita, V., Petrove, V. V., Lyadov, V., Fu, W., Mi, W., Jeong, W. K., Leclercq, W. K. G., De Sousa, X., Zhao, X., Li, X., Wang, X., Yang, X., Zhang, X., Dong, Y., Erushevich, Y., Takii, Y., Sumi, Y., Loli, Y. T., Yifat, Y. L., Shimada, Y., Nabeya, Y., Ide, Y., Wu, Y., Tsukada, Y., Miyamoto, Y., Toiyama, Y., Fujie, Y., Kaneko, Y., Mokutani, Y., Fujii, Y., Kanemitsu, Y., Medkova, Y., Chen, Y., Ruiz, Y. G., Kinugasa, Y., Sow, Z., Razzaq, Z., Wang, Z., Liu, Z., Han, Z., Tai, Z., Lai, Z., Ng, Z. Q., Dambrauskas, Z., An, Y, Bellato, V, Konishi, T, Pellino, G, Sensi, B, Siragusa, L, Franceschilli, M, Sica, G, Kefleyesus, A, Hoofwijk, A, Eldaly, A, Gonzalez, A, Jawad, A, Jooma, A, Hafez, A, Rubio, A, Landaluce-Olavarria, A, Wu, A, Nagatsu, A, Inoue, A, Kanamoto, A, Ouchi, A, El-Hussuna, A, Vazquez-Melero, A, Wolthuis, A, Peral, A, Lozano, A, Efremov, A, Ryasantsev, A, Di Giorgio, A, Parente, A, Tamburrini, A, Alo, A, Forero-Torres, A, Vahrmeijer, A, Varabei, A, Hinojosa, S, Balkan, A, Frontali, A, Oleg, A, Soler-Silva, A, Makni, A, Andre, A, Cabrera, A, Fernandez, A, Minaya-Bravo, A, Rodriguez-Sanchez, A, Musina, A, Pangeni, A, Zolotko, A, Tonoyan, A, Balla, A, Belli, A, Cavallaro, A, Chierici, A, Divizia, A, Bucci, A, Salido, A, Morini, A, Muratore, A, Vignali, A, Chitul, A, Sebastian, D, Pcolkins, A, Shchegolev, A, Hollenbeck, A, Wisneski, A, Iossa, A, D'Amore, A, Hunter, A, Hesketh, A, La Brocca, A, Spinelli, A, Caires, A, D'Alessandro, A, Correo, A, Macri, A, Navarro-Sanchez, A, Pronk, A, Akunc, A, Mehri, A, Pelta, A, Papadopoulos, A, Kechagias, A, Rashid, A, Ramazanov, A, Chandio, A, Kohyama, A, Nishimura, A, Ohkawa, A, Dulskas, A, Jamal, A, Mariani, A, Unal, A, Karagoz, A, Ozkan, B, Salih, B, Gulcu, B, Pessia, B, Martin-Perez, B, Ielpo, B, Tulelli, B, Yang, B, Mhamed, B, Murphy, B, Pirozzi, B, Langenhoff, B, Belevi, B, Guney, B, Ng, C, Rueda, C, Roxburgh, C, Feo, C, Ferrari, C, Gazia, C, Pratesi, C, Ratto, C, Santacruz, C, Arroyave, C, Macias, C, Fernandez, C, Curtis-Martinez, C, Fortmann, C, Kim, C, Galeano, C, Barroso, C, Baldi, C, Foppa, C, Formisano, C, Li, C, Ding, C, Wang, C, Iacusso, C, Yang, C, Pizzera, C, Skias, C, Chouliras, C, Liakos, C, Matsuda, C, Wu, C, Ozaslan, C, Tanda, C, Tommaso, C, Dagorno, C, Ramos, C, Arcudi, C, Coco, C, Morales, C, Ali, M, Lozano, C, Sala, C, Leo, C, Scarpa, C, Ferro, C, Morales-Garcia, D, Nakano, D, Cristian, D, Hechtl, D, Canovas, D, Calabrese, D, Rega, D, Ferraro, D, Morezzi, D, Sommacale, D, Brogden, D, Miskovic, D, Merlini, D, Pertile, D, Coniglio, D, Zhu, D, Wu, D, Coletta, D, Rubio, D, Sasia, D, Fillipov, D, Russiello, D, Dardanov, D, Consten, E, Smolskas, E, Muttillo, E, Jones, E, Sunami, E, Etienne, E, Chalkiadaki, E, Giacomelli, E, Karbovnichaya, E, Ruiz-Ucar, E, Guaitoli, E, Samadov, E, Jovine, E, Treppiedi, E, Vaterlini, E, Zambaiti, E, Moggia, E, Coetzee, E, Chisari, E, D'Errico, E, Ciofic, E, Pena, E, Kurt, E, Balik, E, Gunay, E, Sivrikoz, E, Andolfi, E, Araimo, E, Lucci, E, Opocher, E, Pinotti, E, Rubino, E, Reyhan, E, Mazzotta, E, Navarro, E, El-Helou, E, Licardie-Bolanos, E, Porto, E, Contreras, E, Boerma, E, Cianchi, F, Marino, F, Uggeri, F, Han, F, Calculli, F, Falaschi, F, Ghignone, F, Perrone, F, Borghi, F, Garcia, F, Agresta, F, Cananzi, F, Mendoza-Moreno, F, Cengiz, F, Almeida, F, Baracchi, F, Carannante, F, La Torre, F, Fernandes, F, Friedmacher, F, Grama, F, Carissimi, F, Pecchini, F, Bianco, F, Colombo, F, Ferrara, F, Litta, F, Carrano, F, Martignoni, F, Tasselli, F, Milone, F, Pata, F, Sammartino, F, Zambianchi, F, Barragan, F, Herrero, F, Schlottmann, F, Den Boer, F, Pfeffer, F, Fujita, F, Navarra, G, Herrera-Almario, G, Pozzo, G, Capolupo, G, Van Ramshorst, G, Liscia, G, Gallo, G, Asawa, G, Wang, G, Raiyani, G, Beets, G, Naval, G, Jin, G, Chang, G, Saakian, G, Kahane, G, Borroni, G, Secco, G, Baiocchi, G, Baronio, G, Pagano, G, Pattacini, G, Lisi, G, Milito, G, Sinibaldi, G, Serrao, G, Bagaglini, G, Sarro, G, Brisinda, G, Candilio, G, Mangiameli, G, Giuliani, G, Martin-Martin, G, Bodzin, G, Leon, G, Mackay, G, Vasil, G, Palmisano, G, Giovanna, G, Fernandez, G, Steingel, G, Zhang, G, Choi, G, Chen, H, Hirose, H, Kayano, H, Ulgur, H, Impellizzeri, H, Ariola, H, Liu, H, Medina, H, Miyauchi, H, Takahashi, H, Hayashi, H, Ishikawa, H, Ishida, H, De Vries, H, Ulman, H, Kon, H, Ota, H, Akamatsu, H, Tamagawa, H, Shoji, H, Egi, H, Matsubara, H, Miki, H, Elfeki, H, Lin, H, Giani, I, Caravaca-Garcia, I, Takemasa, I, Angriman, I, Negoi, I, Volkova, I, Russo, I, Kronberger, I, Shageev, I, Aydin, I, Mora Guzman, I, Novak, I, Giuliano, I, Rachmuth, J, Ngu, J, Glasbey, J, Stoot, J, Zatecky, J, Melenhorst, J, Van Der Wal, J, Leijtens, J, Bogach, J, Elliott, J, De Wilt, J, Han, J, Cui, J, Liu, J, Khan, J, Wirawan, J, Zhang, J, Manyari, J, Doerner, J, Bock, J, Konsten, J, Castro, J, Grobas, J, Pereira, J, Juloski, J, Laina, J, Solorzano, J, Lopez, J, Li, J, Watanabe, J, Kwak, J, Hasegawa, J, Hiro, J, Sergey, K, Zhang, K, Nagahori, K, Martinez, K, Tokuhara, K, Danno, K, Uehara, K, Yoshimatsu, K, Ehara, K, Ueda, K, Suda, K, Yamamoto, K, Ishimaru, K, Kimura, K, Hirata, K, Deen, K, Imaizumi, K, Yamada, J, Tanakura, K, Rida, K, Sugimoto, K, Kotaro, K, Shi, K, Okabayashi, K, Hida, K, Kataoka, K, Hongo, K, Xia, K, Tseng, L, Reime, L, Lorenzon, L, Ruano, L, Zhou, L, De Nes, L, Brandariz, L, Morini, L, Petagna, L, Ripamonti, L, Martinez, L, Pio, L, Sacco, L, Carvalho, L, Zorcolo, L, Perez-Sanchez, L, Esparza, L, Aguilar, L, Garner, M, Sugimoto, M, Nagashima, M, Shiozawa, M, Simone, M, Ferrer-Marquez, M, Carvalho, M, Alifano, M, Arganini, M, Calussi, M, Catarci, M, Allaix, M, Forlin, M, Milone, M, Paci, M, Fodor, M, Antipova, M, Martos, M, Giuffrida, M, Tabernilla, M, Quiros, M, Lemma, M, Correo, M, Malowiecka, M, Bellomo, M, Fernandez, M, Socias, M, Rizk, M, Aurora, M, Antolinez, M, Ninkovic, M, De Roos, M, Lara, M, Agustin, M, Cuadrado, M, Pascual, M, Lemmerer, M, Carlos, R, Okamoto, M, Miyo, M, Inomata, M, Ikenaga, M, Tsujie, M, Yasuno, M, Kotake, M, Sato, M, Yasui, M, Lavazza, M, Rottoli, M, Zuin, M, Zuluaga, M, Cervellera, M, Cesari, M, Zizzo, M, Garino, M, Ghirardi, M, Montuori, M, Podda, M, Santarelli, M, Koc, M, Baini, M, Campanelli, M, Manigrasso, M, Zuolo, M, Cunha, M, Misca, M, Slavchev, M, Danilov, M, Shigaev, M, Martens, M, Kobayashi, M, Ren, M, Ishizuka, M, Hassan, M, Siblini, M, Sahloul, M, Keramati, M, Karunakaran, M, Markel, M, Majeed, M, Younis, M, Akin, M, Laraibe, M, Derebey, M, Kendirci, M, Fukunaga, M, Matsubara, N, Ordaz, N, Samalavicius, N, Keeratibharat, N, de Angelis, N, Gica, N, Mariani, N, Ramino, N, Falco, N, Smart, N, De Korte, N, Kok, N, Jamieson, N, Aberyasev, N, Bruklich, N, Ichikawa, N, Miyoshi, N, De Palma, N, Figueiredo, N, Torrecilla, N, Dybov, O, Yudin, O, Crepin, O, Gomez, O, Sert, O, Lominchar, P, Menendez, P, De Nardi, P, Tejedor, P, Jordan, P, Tan, P, Marsanic, P, Natalya, P, Banos, P, Rebasa, P, Neary, P, Tanis, P, Giustacchini, P, Anoldo, P, Concejo, P, Cao, P, Chandrasinghe, P, Abeyratne, P, Wang, Q, Klicks, R, Riquelme, R, Galli, R, Gianesini, R, Moorjani, R, Deshpande, R, Gorter, R, Ledesma, R, Ruslan, R, Chhabra, R, Talreja-Pelaez, R, Suzuki, R, Balestri, R, Rosati, R, Kiblawi, R, Martins, R, Angelico, R, Tutino, R, Persiani, R, Pollastri, R, Lopez, R, Perez, R, Hompes, R, Lukanin, R, Roser Termes Serra, R, Brunaccino, R, Nakanishi, R, Stefan, S, Hernandez, S, Di Carlo, S, Ingallinella, S, Domoto, S, Ikeda, S, Mikalauskas, S, Kim, S, Mantova, S, Barbuta, S, Li, S, Yamaguchi, S, Yamagishi, S, Homma, S, Tsujinaka, S, Yoshioka, S, Mori, S, Tewari, S, Rayman, S, Horiuchi, S, Matoba, S, Morita, S, Yaman, S, Vigna, S, Testa, S, Ng, S, Deidda, S, Cicconi, S, Di Maria, S, Sibio, S, Ersoz, S, Pejkova, S, Altarifi, S, He, S, Malakorn, S, Meindert, S, Sumikawa, S, Parmar, S, Uranitsch, S, D'Ugo, S, Giuliani, S, Breukink, S, Lee, S, Hata, T, Ishikawa, T, Akiyoshi, T, Azuma, T, Kobatake, T, Fukuzaki, T, Aiyama, T, Yamada, T, Garmanova, T, Gomez-Sanchez, T, Yamaguchi, T, Flores, T, Usub, T, Tsuruma, T, Shimizu, T, Hristov, T, Van Loon, T, Funakoshi, T, Manzia, T, Kiyomatsu, T, Katayama, T, Kazuhito, U, Elmore, U, Grossi, U, Truchalev, V, Rodriguez, V, Testa, V, Tonini, V, Celentano, V, Bettencourt, V, Mammadov, V, Leyva, V, Mariscal, V, Seid, V, Klemann, V, Turrado-Rodriguez, V, Papagni, V, Vento, V, Frering, V, Vigorita, V, Petrove, V, Lyadov, V, Fu, W, Mi, W, Jeong, W, Leclercq, W, De Sousa, X, Zhao, X, Li, X, Wang, X, Yang, X, Zhang, X, Dong, Y, Erushevich, Y, Takii, Y, Sumi, Y, Loli, Y, Yifat, Y, Shimada, Y, Nabeya, Y, Ide, Y, Wu, Y, Tsukada, Y, Miyamoto, Y, Toiyama, Y, Fujie, Y, Kaneko, Y, Mokutani, Y, Fujii, Y, Kanemitsu, Y, Medkova, Y, Chen, Y, Ruiz, Y, Kinugasa, Y, Sow, Z, Razzaq, Z, Wang, Z, Liu, Z, Han, Z, Tai, Z, Lai, Z, Ng, Z, and Dambrauskas, Z
Subjects: Surgery, COVID-19, medicine.medical_specialty, 2019-20 coronavirus outbreak, Infectious Disease Transmission, Patient-to-Professional, survey, covid19, Coronavirus disease 2019 (COVID-19), Attitude of Health Personnel, Settore MED/18 - CHIRURGIA GENERALE, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Infectious Disease Transmission, COVID-19. Global surgery, MEDLINE, Global Health, NO, Patient-to-Professional, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], Surveys and Questionnaires, Correspondence, medicine, Global health, Infection control, Humans, General, Personal protective equipment, Personal Protective Equipment, LS7_4, Surgeons, Infection Control, covid-19, pandemic, surgery, SARS-CoV-2, business.industry, Vaccination, COVID-19, covid, Fear, Settore MED/18, Occupational Diseases, Surgeon - infection - COVID19 - survey, Family medicine, Surgery, business
Abstract: During the last three months, COVID- 19 pandemic had led to a serious backlog of operations globally, and plans for restarting operation are imperative. Recommendations for surgical activities were studied, aiming to protect the surgical staff from being infected. In the meantime, it is also important to give attention to the surgeon’s personal feeling during work. We conducted a survey to investigate global surgi- cal practices during the COVID-19 pandemic, and the surgeon’s personal feeling was also investigated in the sur- vey. In this special letter, we performed multivariate analysis to explore factors that associated with surgeon’s fear of getting infected by COVID-19.
Published: 2020

10. A rare case of cardiac tamponade masquerading as acute abdomen

Author: Lucia Romano, Alessandra Di Sibio, Francesco Carlei, Mario Schietroma, Francesco Maffione, Antonio Giuliani, and Denise Brandolin
Subjects: Abdominal pain, medicine.medical_specialty, Electrical alternans, medicine.medical_treatment, Peritonitis, Pericardial effusion, Acute abdomen, 03 medical and health sciences, 0302 clinical medicine, Cardiac tamponade, Case report, medicine, business.industry, medicine.disease, Surgery, medicine.anatomical_structure, Pericardiocentesis, 030220 oncology & carcinogenesis, Abdomen, 030211 gastroenterology & hepatology, medicine.symptom, business
Abstract: Highlights • Acute abdomen is any acute abdominal condition requiring a quick response. • The abdominal discomfort associated with extra-abdominal pathologies could mimic acute abdomen. • Cardiac tamponade is a medical emergency. • The differential diagnosis could be kept in mind to avoid a delayed treatment., Introduction Acute abdomen is any acute abdominal condition requiring a quick response. The incidence varies according to age and disease aetiology. The abdominal discomfort associated with extra-abdominal pathophysiology and thoracic conditions could mimic acute abdomen. In this case we report a rare case of a young patient with cardiac tamponade masquerading as acute abdomen. Presentation of case A 25-years-old African man presented to the Emergency Department with abdominal pain. An EKG was performed, which revealed sinus tachycardia, with electrical alternans and borderline reduced voltage. At the time of the admission to our unit, he had a clinical worsening and a CT scan of abdomen was performed, which demonstrated hepatomegaly, abundant pericardial effusion and thin right pleural effusion at the lung bases. An echocardiogram confirmed a circumferential pericardial effusion with initial collapse of the right ventricular free wall. It was decided to immediately transport the patient to the Cardiosurgery Unit of another hospital to undergo pericardiocentesis. Discussion Our experience with this case underlines the important point that patients with a large pericardial effusion may present with the clinical features of acute abdomen and peritonitis. Abdominal pain was the primary symptom that prompted this patient to seek medical attention. Conclusion Acute abdomen is any acute abdominal condition requiring a rapid, often surgical, treatment. Cardiac tamponade is a medical emergency. The differential diagnosis could be kept in mind by any emergency physician, surgeon and anaesthesiologist, because an incorrect diagnosis and therefore an incorrect treatment or a delay in pericardial evacuation can be life-threatening.
Published: 2020

11. Lung optimized treatment with CyberKnife® in inoperable lung cancer patients: feasibility analysis of a mono-institutional 115 patient series

Author: C. Francia, S. Arculeo, Lorenzo Spaggiari, F. De Marinis, S. Vigorito, Matteo Pepa, Elena Rondi, Annamaria Ferrari, Gaia Piperno, Sara Trivellato, Federica Cattani, Maria Alessia Zerella, Giulia Marvaso, Cristiana Fodor, D. Sibio, Delia Ciardo, Barbara Alicja Jereczek-Fossa, Sara Gandini, and Roberto Orecchia
Subjects: Adult, Cancer Research, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Treatment of lung cancer, Radiosurgery, 03 medical and health sciences, 0302 clinical medicine, Cyberknife, Concomitant Therapy, medicine, Humans, Lung cancer, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Dose fractionation, Middle Aged, medicine.disease, Survival Rate, Radiation therapy, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Concomitant, Feasibility Studies, Dose Fractionation, Radiation, Radiology, business
Abstract: CyberKnife® Lung Optimized Treatment (LOT) allows the treatment of lung cancer without invasive fiducial implantation. The aim of this retrospective analysis was to evaluate the feasibility, toxicity and clinical outcome. One hundred fifteen patients (124 lesions) were treated with CyberKnife® using LOT. The median age was 72.6 years (range 31.8-90.3). From 124 treated lesions, 52 were with histopathological confirmation (41 primitive pulmonary cancers, 8 pulmonary metastases) and 72 as untyped tumors. For 5 patients (6 lesions) treatment was an in-field re-irradiation. Concomitant therapy was administered in 7 patients. Zero-View tracking was applied in 69 patients, 1-View in 33 patients, 2-View in 22 patients. The median total dose was 45 Gy (range 18-54), median dose/fraction was 15 Gy (range 4-18) with a median prescription isodose of 80% (range 68-85). The median planning target volume (PTV) was 25 cm3 (range 3-195). The median follow-up was 20 months (range 7-47). Thirty-seven patients (32%) were alive with no evidence of disease, 39 patients (34%) were alive with clinically evident disease, and 38 patients (33%) died of the disease. The 1- and 2-year overall survival (OS) rate was 83% and 61%. The median time to progression was 19 months (95% confidence interval: 11-19 months), 1- and 2-year progression-free survival (PFS) rates were 62% and 41%, respectively. Smaller PTV was significantly associated with better OS, PFS and in-field PFS in univariate and multivariate analyses. Acute toxicity was observed in 36 patients (41%). Late toxicity was registered in 25 patients (29%). G3 late toxicity was observed in one patient (1.1%). Our data suggest that fiducial less-stereotactic body radiation therapy (SBRT) is a feasible, well-tolerated and potentially effective treatment with high compliance in the setting of inoperable patients due to concomitant disease or previous treatments.
Published: 2020

12. CVD diamond detectors for fast VUV and SX-ray diagnostics on FTU

Author: E. Milani, Silvia Palomba, A. Romano, B. Tilia, G. Rocchi, A. Sibio, Claudio Verona, V. Piergotti, Gianluca Verona-Rinati, Gerarda Apruzzese, Maurizio Angelone, F. Bombarda, Silvia Cesaroni, Marco Marinelli, L. Gabellieri, A. Grosso, Cristina Centioli, G. Pucella, Bombarda, F., Angelone, M., Apruzzese, G., Centioli, C., Cesaroni, S., Gabellieri, L., Grosso, A., Marinelli, M., Milani, E., Palomba, S., Piergotti, V., Pucella, G., Rocchi, G., Romano, A., Sibio, A., Tilia, B., Verona, C., and Verona-Rinati, G.
Subjects: Nuclear and High Energy Physics, Materials science, Tokamak, business.industry, Divertor, Settore FIS/04, Bolometer, Diamond, Photodetector, Plasma, engineering.material, Condensed Matter Physics, law.invention, Photodiode, Polychromator, laboratory plasma, Optics, law, engineering, diagnostics, business, chemical vapor deposition diamonds
Abstract: The diagnostic performances of photodetectors based on Chemical Vapor Deposition (CVD) single crystal diamonds that were installed on one of the equatorial ports of the FTU tokamak during the last six months of operation of the machine are reported. Examples of plasma fast events have been collected in several different plasma conditions, confirming the fast response capabilities of diamond detectors and the high S/N ratio. During the Runaway Control and Mitigation experiments, for example, the so-called Anomalous Doppler Instabilities were observed as sharp peaks of Ly-α emission caused by fast electrons hitting the wall, as a result of RE beam instabilities, perfectly correlated in time with other magnetic diagnostics and fast EC polychromator signals. Fast oscillations in the plasma emission are also observed in the presence of tearing modes, while other interesting observations relate to pellet ablation processes. The CVD diamond detectors were installed on FTU in view of their possible use for replacement of the Si photodiodes currently adopted for Soft X-Ray tomography (SXT) on future devices with harsher radiation environments. In fact, it was realized that the relatively flat response of the UV diamond sensor opened the possibility of using these detectors as bolometers. The first encouraging results have prompted launching an R&D program for the development of full-fledged diamond bolometers, which will be especially well suited for the coverage of the divertor and edge regions in high performance devices, in the energy range from 10 eV to about 20 keV.
Published: 2021

13. Central vascular ligation and mesentery based abdominal surgery

Author: Piero Rossi, Danilo Vinci, S. Di Carlo, Roberto Caronna, Bruno Sensi, Simone Sibio, Andrea Martina Guida, Marzia Franceschilli, Vittoria Bellato, and Leandro Siragusa
Subjects: Laparoscopic surgery, Cancer Research, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Complete mesenteric excision, central vascular ligation, colorectal cancer, gastric cancer, pancreatic head cancer, lymphadenectomy, laparoscopy, minimally invasive approach, Review, Endocrinology, Surgical oncology, Pancreatic cancer, medicine, RC254-282, Pancreatic head cancer, Endocrine and Autonomic Systems, business.industry, Minimally invasive approach, General surgery, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Multimodal therapy, Lymphadenectomy, medicine.disease, Colorectal cancer, Central vascular ligation, Radiation therapy, Oncology, Laparoscopy, business, Gastric cancer, Abdominal surgery
Abstract: In the nineteenth century the idea of a correct surgical approach in oncologic surgery moved towards a good lymphadenectomy. In colon cancer the segment is removed with adjacent mesentery, in gastric cancer or pancreatic cancer a good oncologic resection is obtained with adequate lymphadenectomy. Many guidelines propose a minimal lymph node count that the surgeon must obtain. Therefore, it is essential to understand the adequate extent of lymphadenectomy to be performed in cancer surgery. In this review of the current literature, the focus is on “central vascular ligation”, understood as radical lymphadenectomy in upper and lower gastrointestinal cancer, the evolution of this approach during the years and the improvement of laparoscopic techniques. For what concerns laparoscopic surgery, the main goal is to minimize post-operative trauma introducing the “less is more” concept whilst preserving attention for oncological outcomes. This review will demonstrate the importance of a scientifically based standardization of oncologic gastrointestinal surgery, especially in relation to the expansion of minimally invasive surgery and underlines the importance to further investigate through new randomized trials the role of extended lymphadenectomy in the new era of a multimodal approach, and most importantly, an era where minimally invasive techniques and the idea of “less is more” are becoming the standard thought for the surgical approach.
Published: 2021

14. Clinical characteristics and outcomes of invasively ventilated patients with COVID-19 in Argentina (SATICOVID): a prospective, multicentre cohort study

Author: Cecilia I Loudet, V S Kanoore Edul, F Kurban, G Fernández, S Barrios, B Lattanzio, A Turano, A Kovac, M Cini, E Cornú, C Servin, C I Loudet, A Dubin, T Huanca, C Garay, S Eiguren, Paolo N Rubatto Birri, Fernando G Ríos, F Maicol, P Casteluccio, Arnaldo Dubin, Cristina Orlandi, Rosa Reina, L Kumar, N Nihany, V Mendiluce, S Torres, G C Izzo, C Villavicencio, C Marchena, M Guaymas, V Leiva, F Pugliese, A M Mazzola, G Badariotti, M Ferriccioni, D Piezny, A Risso Vazquez, H Nuñez, Elisa Estenssoro, M G Quintana, F Larocca, E Díaz Rousseaux, N Rosales, I Romero, Eleonora Cunto, F Sacco, M Falcone, A J Herrera, J P Sottile, D Villalba, Vanina S Kanoore Edul, J C Pendino, M Deheza Lonardi, A Zavattieri, Vanina Aphalo, E Estenssoro, J M Pintos, M Andrian, G Echevarría, M Mugno, P Helca Regis, Gustavo Plotnikow, P N Rubatto Birri, M Lugaro, R Luna, María G Sáenz, Y Saad, N Tornatore, D Chiacchiara, M G Sáenz, L Talamonti, J C Medina, M Chamadoira, J Bergesio, Damián Piezny, A Oholeguy, R Reina, C Cesio, J Sagardía, C Pellegrini, R Hernández, M L Campassi, C Orlandi, M Esperatti, María F Valenti, H Cabrera, E Cunto, R A Gómez, F Villarejo, O Hamada, C Tascón, Norberto Tiribelli, V Mandich, S Sac, C González, P Machare, C Marazzi, J Carnero Echegaray, G Genovese, H Alul, M F Valenti, P Rodríguez, C García Almirón, J Sakugawa, A Di Sibio, D Vázquez, F Rópolo, N Tiribelli, H Collazos, Macarena Andrian, C Giuggia, F Pálizas, M Bezzi, V Aphalo, J Ivacachi, F Skrzypiec, V Vilaseca, G Domeniconi, F Iglesias, Ignacio Romero, Marco Bezzi, C Villafañe, M Búsico, Verónica Mandich, N Aramayo, C Groer, S Fredes, A Bobadilla, P Maskin, M J Zec Baskarad, A Barrientos, G Zakalik, M Mogadouro, Carla Groer, M O Pozo, V Thomas, G Plotnikow, N Dargains, N Funes Nelson, D Noval, S Borello, Sebastián Torres, M Quinteros, D Sánchez, V Chediack, D Banegas, V Mezzina, C Balasini, and F Ríos
Subjects: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, Argentina, law.invention, Young Adult, Risk Factors, law, Intubation, Intratracheal, Tidal Volume, Humans, Medicine, Hospital Mortality, Prospective Studies, Prospective cohort study, Tidal volume, Aged, Mechanical ventilation, SARS-CoV-2, business.industry, Septic shock, Hazard ratio, COVID-19, Articles, Middle Aged, medicine.disease, Respiration, Artificial, Intensive care unit, Intensive Care Units, Treatment Outcome, COVID-19 Nucleic Acid Testing, Emergency medicine, Breathing, Female, Respiratory Insufficiency, business, Cohort study
Abstract: Summary Background Although COVID-19 has greatly affected many low-income and middle-income countries, detailed information about patients admitted to the intensive care unit (ICU) is still scarce. Our aim was to examine ventilation characteristics and outcomes in invasively ventilated patients with COVID-19 in Argentina, an upper middle-income country. Methods In this prospective, multicentre cohort study (SATICOVID), we enrolled patients aged 18 years or older with RT-PCR-confirmed COVID-19 who were on invasive mechanical ventilation and admitted to one of 63 ICUs in Argentina. Patient demographics and clinical, laboratory, and general management variables were collected on day 1 (ICU admission); physiological respiratory and ventilation variables were collected on days 1, 3, and 7. The primary outcome was all-cause in-hospital mortality. All patients were followed until death in hospital or hospital discharge, whichever occurred first. Secondary outcomes were ICU mortality, identification of independent predictors of mortality, duration of invasive mechanical ventilation, and patterns of change in physiological respiratory and mechanical ventilation variables. The study is registered with ClinicalTrials.gov, NCT04611269, and is complete. Findings Between March 20, 2020, and Oct 31, 2020, we enrolled 1909 invasively ventilated patients with COVID-19, with a median age of 62 years [IQR 52–70]. 1294 (67·8%) were men, hypertension and obesity were the main comorbidities, and 939 (49·2%) patients required vasopressors. Lung-protective ventilation was widely used and median duration of ventilation was 13 days (IQR 7–22). Median tidal volume was 6·1 mL/kg predicted bodyweight (IQR 6·0–7·0) on day 1, and the value increased significantly up to day 7; positive end-expiratory pressure was 10 cm H2O (8–12) on day 1, with a slight but significant decrease to day 7. Ratio of partial pressure of arterial oxygen (PaO2) to fractional inspired oxygen (FiO2) was 160 (IQR 111–218), respiratory system compliance 36 mL/cm H2O (29–44), driving pressure 12 cm H2O (10–14), and FiO2 0·60 (0·45–0·80) on day 1. Acute respiratory distress syndrome developed in 1672 (87·6%) of patients; 1176 (61·6%) received prone positioning. In-hospital mortality was 57·7% (1101/1909 patients) and ICU mortality was 57·0% (1088/1909 patients); 462 (43·8%) patients died of refractory hypoxaemia, frequently overlapping with septic shock (n=174). Cox regression identified age (hazard ratio 1·02 [95% CI 1·01–1·03]), Charlson score (1·16 [1·11–1·23]), endotracheal intubation outside of the ICU (ie, before ICU admission; 1·37 [1·10–1·71]), vasopressor use on day 1 (1·29 [1·07–1·55]), D-dimer concentration (1·02 [1·01–1·03]), PaO2/FiO2 on day 1 (0·998 [0·997–0·999]), arterial pH on day 1 (1·01 [1·00–1·01]), driving pressure on day 1 (1·05 [1·03–1·08]), acute kidney injury (1·66 [1·36–2·03]), and month of admission (1·10 [1·03–1·18]) as independent predictors of mortality. Interpretation In patients with COVID-19 who required invasive mechanical ventilation, lung-protective ventilation was widely used but mortality was high. Predictors of mortality in our study broadly agreed with those identified in studies of invasively ventilated patients in high-income countries. The sustained burden of COVID-19 on scarce health-care personnel might have contributed to high mortality over the course of our study in Argentina. These data might help to identify points for improvement in the management of patients in middle-income countries and elsewhere. Funding None. Translation For the Spanish translation of the Summary see Supplementary Materials section.
Published: 2021

15. Poorly differentiated neuroendocrine rectal carcinoma with uncommon immune-histochemical features and clinical presentation with a subcutaneous metastasis, treated with first line intensive triplet chemotherapy plus bevacizumab FIr-B/FOx regimen: an experience of multidisciplinary management in clinical practice

Author: Gemma Bruera, Antonio Giuliani, Lucia Romano, Alessandro Chiominto, Alessandra Di Sibio, Stefania Mastropietro, Pierluigi Cosenza, Enrico Ricevuto, Mario Schietroma, Francesco Carlei, and on behalf of Oncology Network ASL1 Abruzzo
Subjects: Male, Cancer Research, medicine.medical_specialty, Bevacizumab, Biopsy, FIr-B/FOx, NEC, Neuroendocrine carcinoma, Subcutaneous metastasis, Thyroid transcription factor-1, Triplet chemotherapy plus bevacizumab, Thyroid Nuclear Factor 1, Synaptophysin, Rectum, Case Report, Neuroendocrine tumors, Irinotecan, lcsh:RC254-282, Antineoplastic Agents, Immunological, Surgical oncology, Antineoplastic Combined Chemotherapy Protocols, Genetics, Carcinoma, Medicine, Humans, Aged, biology, business.industry, Rectal Neoplasms, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Carcinoma, Neuroendocrine, Oxaliplatin, Regimen, medicine.anatomical_structure, Treatment Outcome, Oncology, Subcutaneous nodule, biology.protein, Radiology, Fluorouracil, business, medicine.drug
Abstract: Background Neuroendocrine tumors (NETs) are heterogeneous, widely distributed tumors arising from neuroendocrine cells. Gastrointestinal (GI)-NETs are the most common and NETs of the rectum represent 15, 2% of gastrointestinal malignancies. Poorly differentiated neuroendocrine carcinomas of the GI tract are uncommon. We report a rare case of poorly differentiated locally advanced rectal neuroendocrine carcinoma with nodal and a subcutaneous metastasis, with a cytoplasmic staining positive for Synaptophysin and Thyroid Transcription Factor-1. Case presentation A 72-year-old male presented to hospital, due to lumbar, abdominal, perineal pain, and severe constipation. A whole-body computed tomography scan showed a mass of the right lateral wall of the rectum, determining significant reduction of lumen caliber. It also showed a subcutaneous metastasis of the posterior abdominal wall. Patient underwent a multidisciplinary evaluation, diagnostic and therapeutic plan was shared and defined. The pathological examination of rectal biopsy and subcutaneous nodule revealed features consistent with small-cell poorly differentiated neuroendocrine carcinoma. First line medical treatment with triplet chemotherapy and bevacizumab, according to FIr-B/FOx intensive regimen, administered for the first time in this young elderly patient affected by metastatic rectal NEC was highly active and tolerable, as previously reported in metastatic colo-rectal carcinoma (MCRC). A consistent rapid improvement in clinical conditions were observed during treatment. After 6 cycles of treatment, CT scan and endoscopic evaluation showed clinical complete response of rectal mass and lymph nodes; patient underwent curative surgery confirming the pathologic complete response at PFS 9 months. Discussion and conclusions This case report of a locally advanced rectal NEC with an unusual subcutaneous metastasis deserves further investigation of triplet chemotherapy-based intensive regimens in metastatic GEP NEC.
Published: 2019

16. Nerve root metastasis of gastric adenocarcinoma: A case report and review of the literature

Author: Mario Schietroma, Antonio Giuliani, Marco Varrassi, Marco Perri, Francesco Carlei, Antonio Iacopino, Carlo Masciocchi, Maria Carmela De Donato, Lucia Romano, Ernesto Di Cesare, and Alessandra Di Sibio
Subjects: Pathology, medicine.medical_specialty, Nerve root, Malignancy, Article, Metastasis, Thyroid carcinoma, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, medicine, business.industry, Spinal nerve root ganglion neoplasm, medicine.disease, Ganglion, Ductal Breast Carcinoma, Radiation therapy, medicine.anatomical_structure, Metastatic gastric cancer, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, Sarcoma, business
Abstract: Highlights • Metastatic involvement of peripheral nerves by perineural invasion from an adjacent cancer is not uncommon. • Nerve root metastasis without extension from an adjacent process has been seldom reported in case of solid tumors. • No cases of gastric adenocarcinoma metastasis to the nerves have been reported to date. • In case of known malignancy and refractory pain, the possibility of a nerve root metastasis should be considered., Introduction Nerve root metastasis without extension from an adjacent process has been seldom reported in case of solid tumors. We describe a case of solitary nerve root metastasis of gastric adenocarcinoma, likely due to hematogenous spread. Case presentation A 75-year-old man presented with radiculopathy refractory to medical treatment. MRI and CT demonstrated a right-sided S1 nerve root mass involving the spinal ganglion in its intra-foraminal region with avid enhancement, initial erosive bone changes on sacral foramina and focal hyperaccumulation on 18F – FDG CT-PET, suspicious for metastasis. The histopathological examination confirmed a metastasis of gastric adenocarcinoma. Discussion A review of the current literature revealed only ten cases of hematogenous metastases to spinal nerve root ganglia; the primary lesions in those cases were an oat cell carcinoma of the lung, two cases of colonic adenocarcinoma, a case of uterine adenocarcinoma, a ductal breast carcinoma, a Ewing’s sarcoma, a Renal Cell Carcinoma, a gastro-intestinal stromal tumor, a follicular thyroid carcinoma, a pulmonary adenocarcinoma. Conclusion In the setting of a known malignancy, a nerve root metastasis should be considered in the differential diagnosis of a nerve root mass, although it occurs very rarely.
Published: 2019

17. Prognostic Factors Influencing Infectious Complications after Cytoreductive Surgery and HIPEC: Results from a Tertiary Referral Center

Author: Simone Sibio, Francesco Lefoche, Giuseppe La Torre, Paolo Sammartino, Francesco Di Marzo, Claudia D'Agostino, Ludovica Carbonari, Maurizio Cardi, and Giovanni Battista Fonsi
Subjects: medicine.medical_specialty, Multivariate analysis, Article Subject, HIPEC, Hepatology, Performance status, business.industry, Gastroenterology, prognostic factors, Postoperative complication, Perioperative, Surgery, peritoneal metastases, infectious complications, peritoneal metastases, cytoreductive surgery, HIPEC, infectious complications, prognostic factors, Conventional PCI, medicine, cytoreductive surgery, Referral center, lcsh:Diseases of the digestive system. Gastroenterology, Hyperthermic intraperitoneal chemotherapy, lcsh:RC799-869, business, Cytoreductive surgery, Research Article
Abstract: Background. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) showed promising results in selected patients. High morbidity restrains its wide application. The aim of this study was to report postoperative infectious complications and investigate possible correlations with the preoperative nutritional status and other prognostic factors in patients with peritoneal metastases treated with CRS and HIPEC. Methods. For the study, we reviewed the clinical records of all patients with peritoneal metastases from different primary cancers treated with CRS and HIPEC in our Institution from November 2000 to December 2017. Patients were divided according to their nutritional status (SGA) into groups A (well-nourished) and B/C (mild or severely malnourished, respectively). Possible statistical correlations between risk factors and postoperative complication rates have been investigated by univariate and multivariate analysis. Results. Two hundred patients were selected and underwent CRS and HIPEC during the study period. Postoperative complications occurred in 44% of the patients, 35.3% in SGA-A patients, and 53% in SGA-B/C patients. Cause of complications was infective in 42, noninfective in 37, and HIPEC related in 9 patients. Infectious complications occurred more frequently in SGA-B/C patients (32.6% vs. 9.8% of SGA-A patients). The most frequent sites of infection were surgical site infections (SSI, 35.7%) and central line-associated bloodstream infections (CLABSI, 26.2%). The most frequent isolated species was Candida (22.8%). ASA score, blood loss, performance status, PCI, large bowel resection, postoperative serum albumin levels, and nutritional status correlated with higher risk for postoperative infectious complications. Conclusions. Malnourished patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy are more prone to postoperative infectious complications, and adequate perioperative nutritional support should be considered, including immune-enhancing nutrition. Sequential monitoring of common sites of infection, antifungal prevention of candidiasis, and careful patient selection should be implemented to reduce the complication rate.
Published: 2019

18. Intracranial ependymomas: The role of advanced neuroimaging in diagnosis and management

Author: Carlo Masciocchi, Flavia Cobianchi Bellisari, Federico Bruno, Emanuele Tommasino, Alessandra Splendiani, Hambra Di Vitantonio, Marco Varrassi, Maria Carmela De Donato, Alessandra Di Sibio, and Ernesto Di Cesare
Subjects: Ependymoma, medicine.medical_specialty, Magnetic Resonance Spectroscopy, Adolescent, supratentorial ependymoma, Neuroimaging, Diagnosis, Differential, Anaplastic Ependymoma, 03 medical and health sciences, ependymoma CT, 0302 clinical medicine, Diagnosis, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Review Articles, Tomography, business.industry, anaplastic ependymoma, ependymoma MRI, intracranial ependymoma, Brain Neoplasms, Female, Magnetic Resonance Imaging, Tomography, X-Ray Computed, General Medicine, medicine.disease, X-Ray Computed, 030220 oncology & carcinogenesis, Differential, Intracranial ependymoma, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery
Abstract: Intracranial ependymomas represent a rare subgroup of glial tumours, showing a wide variety of imaging characteristics, often representing a challenging diagnosis for neuroradiologists. Here, we review the most recent scientific Literature on intracranial ependymomas, highlighting the most characteristic computed tomography and magnetic resonance imaging features of these neoplasms, along with epidemiologic data, recent classification aspects, clinical presentation and conventional therapeutic strategies. In addition, we report an illustrative case of an 18-year-old girl presenting with an intracranial supratentorial, anaplastic ependymoma, with the aim of contributing to the existing knowledge and comprehension of this rare tumour.
Published: 2021

19. Surgical management of adrenocortical carcinoma: current highlights

Author: Daniele Crocetti, Andrea Polistena, Mariarita Tarallo, Simone Sibio, Ambra Chiappini, Claudio Letizia, Giuseppe Cavallaro, Giorgio De Toma, Enrico Fiori, and Luigi Petramala
Subjects: medicine.medical_specialty, Adrenocortical carcinoma, robotic adrenalectomy, QH301-705.5, medicine.medical_treatment, Medicine (miscellaneous), 030209 endocrinology & metabolism, Review, Cochrane Library, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, current methods of treatment, laparoscopic adrenalectomy, Medicine, Biology (General), Stage (cooking), Adrenal tumors, Laparoscopic adrenalectomy, business.industry, General surgery, Adrenalectomy, Gold standard, medicine.disease, Time to recurrence, 030220 oncology & carcinogenesis, business
Abstract: Introduction: Adrenocortical carcinoma (ACC) is a rare tumor, often discovered at an advanced stage and associated with poor prognosis. Treatment is guided by staging according to the European Network for the Study of Adrenal Tumors (ENSAT) classification. Surgery is the treatment of choice for ACC. The aim of this review is to provide a complete overview on surgical approaches and management of adrenocortical carcinoma. Methods: This comprehensive review has been carried out according to the PRISMA statement. The literature sources were the databases PubMed, Scopus and Cochrane Library. The search thread was: ((surgery) OR (adrenalectomy)) AND (adrenocortical carcinoma). Results: Among all studies identified, 17 were selected for the review. All of them were retrospective. A total of 2498 patients were included in the studies, of whom 734 were treated by mini-invasive approaches and 1764 patients were treated by open surgery. Conclusions: Surgery is the treatment of choice for ACC. Open adrenalectomy (OA) is defined as the gold standard. In recent years laparoscopic adrenalectomy (LA) has gained more popularity. No significant differences were reported for overall recurrence rate, time to recurrence, and cancer-specific mortality between LA and OA, in particular for Stage I-II. Robotic adrenalectomy (RA) has several advantages compared to LA, but there is still a lack of specific documentation on RA use in ACC.
Published: 2021

20. Perforated gastric cancer. A critical appraisal

Author: Piero Rossi, Simone Sibio, Giuseppe Cavallaro, Sara Di Carlo, Marzia Franceschilli, Danilo Vinci, and Maurizio Cardi
Subjects: Cancer Research, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Perforation (oil well), MEDLINE, Peritonitis, Review, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Perforated gastric tumor, Surgical oncology, Gastrectomy, medicine, Perforation, Endocrine and Autonomic Systems, business.industry, Gastric cancer · Perforated gastric tumor · Perforation · Peritonitis · Gastrectomym, General surgery, Mortality rate, Cancer, medicine.disease, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Lymphadenectomy, business, Gastric cancer
Abstract: Gastric cancer perforation is a life-threatening condition that accounts for less than 5% of all gastric cancer patients and typically requires emergency surgery. However, preoperative diagnosis is difficult and management has a dual purpose: to treat peritonitis and to achieve a curative resection. The optimal surgical strategy is still unclear and prognosis remains poor. A search of the literature was performed using MEDLINE databases (Pubmed, EMBASE, Web of Science and Cochrane) using terms such as “perforated gastric cancer”, “perforated gastric cancer and surgery”, “perforated gastric tumour” and “gastric cancer perforated”. Case reports, other reviews, non-english written papers and papers written before 2010 were excluded. Eight articles published between 2010 and 2020 matched the inclusion criteria for this review. Perforated gastric cancer was more prevalent in elderly males. Distal stomach was most frequently involved. Preoperative diagnosis was uncommon. Mortality rates ranged from 2 to 46%. Patients able to receive an R0 resection demonstrated better long-term survival compared with patients who had simple closure procedures. Laparoscopic procedure was mentioned only in one study. In an emergency situation, curative RO resection should always be offered in patients without multiple adverse factors. A surgical strategy using laparoscopic local repair as first step of surgery to resolve the peritonitis followed by a radical open or laparoscopic gastrectomy with lymphadenectomy could be considered. A balance between emergency and oncological needs should drive the surgical choice on a case by case basis.
Published: 2021

21. Prehospital Hemorrhage Assessment Criteria: A Concise Review

Author: Sara Di Carlo, Maurizio Cardi, Giuseppe Cavallaro, Piero Rossi, Simone Sibio, Giuseppe S. Sica, and Kenia Palomeque
Subjects: Adult, medicine.medical_specialty, Emergency Medical Services, quantitative measures, Vital signs, Hemorrhage, Emergency Nursing, Shock, Hemorrhagic, Critical Care Nursing, Blood loss, emergency, exsanguination, hemorrhagic shock, prehospital care, trauma, medicine, Humans, Glasgow Coma Scale, Intensive care medicine, Monitoring, Physiologic, Advanced and Specialized Nursing, business.industry, Data synthesis, Settore MED/18, Blood pressure, Data extraction, Shock (circulatory), Hemorrhagic shock, Wounds and Injuries, medicine.symptom, business
Abstract: OBJECTIVE Early assessment of the clinical status of trauma patients is crucial for guiding the treatment strategy, and it requires a rapid and systematic approach. The aim of this report is to critically review the assessment parameters currently used in the prehospital setting to quantify blood loss in trauma. DATA SOURCES Studies regarding hemorrhagic shock in trauma were pooled from PubMed, EMBASE, and Cochrane databases using key words such as "hemorrhagic shock," "vital signs evaluation," "trauma," "blood loss," and "emergency medical service," alone or combined. STUDY SELECTION Articles published since 2009 in English and Italian were considered eligible if containing data on assessment parameters in blood loss in adults. DATA EXTRACTION Sixteen articles matching the inclusion criteria were considered in our study. DATA SYNTHESIS Current prehospital assessment measures lack precise correlation with blood loss. CONCLUSIONS Traditional assessment parameters such as heart rate, systolic blood pressure, shock index, and Glasgow Coma Scale score often lag in providing accurate blood loss assessment. The current literature supports the need for a noninvasive, continuously monitored assessment parameter to identify early shock in the prehospital setting.
Published: 2021

22. Complete mesocolic excision and central vascular ligation in colorectal cancer in the era of minimally invasive surgery

Author: Simone Sibio, Piero Rossi, Sara Di Carlo, Giuseppe Cavallaro, Andrea Martina Guida, Leandro Siragusa, Marzia Franceschilli, Danilo Vinci, Vittoria Bellato, Bruno Sensi, and Roberto Caronna
Subjects: Opinion Review, medicine.medical_specialty, Colorectal cancer, medicine.medical_treatment, laparoscopy, Context (language use), colorectal cancer, Complete mesenteric excision, central vascular ligation, lymphadenectomy, minimally invasive surgery, medicine, Gastrointestinal cancer, Laparoscopy, medicine.diagnostic_test, business.industry, Cancer, General Medicine, Fascia, medicine.disease, Surgery, medicine.anatomical_structure, Lymphadenectomy, business, Ligation
Abstract: Since the 19th century, appropriate lymphadenectomy has been considered a cornerstone of oncologic surgery and one of the most important prognostic factors. This approach can be applied to any surgery for gastrointestinal cancer. During surgery for colon and rectal cancer, an adequate portion of the mesentery is removed together with the segment of bowel affected by the disease. The adequate number of lymph nodes to be removed is standardized and reported by several guidelines. It is mandatory to determine the appropriate extent of lymphadenectomy and to balance its oncological benefits with the increased morbidity associated with its execution in cancer patients. Our review focuses on the concept of "complete mesenteric excision (CME) with central vascular ligation (CVL)," a radical lymphadenectomy for colorectal cancer that has gained increasing interest in recent years. The aim of this study was to evaluate the evolution of this approach over the years, its potential oncologic benefits and potential risks, and the improvements offered by laparoscopic techniques. Theoretical advantages of CME are improved local-relapse rates due to complete removal of the intact mesocolic fascia and improved distance recurrence rates due to ligation of vessels at their origin (CVL) which guarantees removal of a larger number of lymph nodes. The development and worldwide diffusion of laparoscopic techniques minimized postoperative trauma in oncologic surgery, providing the same oncologic results as open surgery. This has been widely applied to colorectal cancer surgery; however, CME entails a technical complexity that can limit its wide minimally-invasive application. This review analyzes results of these procedures in terms of oncological outcomes, technical feasibility and complexity, especially within the context of minimally invasive surgery.
Published: 2021

23. PO-1670 Clinical implementation of MRI-only radiotherapy workflow for prostate cancer with a standard linac

Author: Angelo Vanzulli, S. Nici, C. Carbonini, A.F. Monti, Stefano Riga, C. Carsana, C. Potente, M.G. Brambilla, D. Sibio, B. Bortolato, M.M.J. Felisi, R.G. Pellegrini, Domenico Lizio, Alberto Torresin, and Mauro Palazzi
Subjects: Radiation therapy, medicine.medical_specialty, Prostate cancer, Workflow, Oncology, business.industry, medicine.medical_treatment, medicine, Radiology, Nuclear Medicine and imaging, Hematology, Radiology, medicine.disease, business
Published: 2021

24. A two colour interferometer for PROTO-SPHERA experiment

Author: V. Piergotti, G. Galatola Teka, C. Mazzotta, B. Tilia, A. Sibio, G. Rocchi, P. Micozzi, F. Alladio, A. Grosso, O. Tudisco, Mazzotta, C., Tudisco, O., Galatola Teka, G., Alladio, F., Grosso, A., Micozzi, P., Rocchi, G., Piergotti, V., Sibio, A., and Tilia, B.
Subjects: Physics, Electron density, Interferometer, Plasma diagnostics, Spherical tokamak, Plasma diagnostic, Plane (geometry), business.industry, Mechanical Engineering, Torus, Plasma, Interferometry, Optics, Nuclear Energy and Engineering, Pinch, General Materials Science, business, Civil and Structural Engineering
Abstract: PROTO-SPHERA (Spherical Plasma for Helicity Relaxation Assessment) is a new concept of torus that aims to produce a spherical torus with closed flux surfaces and a force-free Screw Pinch with open flux surfaces, fed by electrodes. In order to verify the stability of the configuration and the technical components of the PROTO-SPHERA initial arc, the initial Phase-1 experiment was built, and its plasma, in the year 2108, has reached both the total current (10 kA) and total duration (1 s) targets. A two colour interferometer is one of the diagnostic system proposed to provide PROTO-SPHERA with the measurement of its electron density, which is currently of the order of ∼1020 m−3. It will allow to obtain line density, necessary to characterize this uncommon plasma, as integrate measurement along the equatorial plane. The design and the interferometer characteristics are described in this paper.
Published: 2019

25. Impact of surgery on quality of life in Crohn's disease: short- and mid-term follow-up

Author: Simone Sibio, G Bagaglini, Francesca Romano, Bruno Sensi, Stefano D’Ugo, Giovanni Monteleone, Livia Biancone, and Giuseppe S. Sica
Subjects: Laparoscopic surgery, Crohn’s disease, Quality of life, Adult, Male, medicine.medical_specialty, Time Factors, media_common.quotation_subject, medicine.medical_treatment, Happiness, Disease, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Crohn Disease, medicine, Humans, Laparoscopy, media_common, Crohn's disease, Medical treatment, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, humanities, Surgery, Settore MED/18, Mid term follow up, Treatment Outcome, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Female, business, Follow-Up Studies
Abstract: Active Crohn’s disease has a substantial impact on Quality of Life (QoL). Medical management could be associated to side effects, hospitalization, long treatment period and requires patient's compliance, impacting QoL. Ileocecal resection (ICR) is often required, open or laparoscopic. Aim of the study was to assess Health-Related (HR) QoL changes following ICR, and to identify factors impacting on QoL in the short and mid-term. From a single institution, we created a prospective database of patients undergoing ICR from 01/2009 to 12/2015. HRQoL was analysed with Cleveland Global Quality of Life (CGQL) score, Overall Quality of Happiness (OQH), and asking patients if they would have surgery again. QoL scores were recorded at 30 days, 6, 12 and 36 months postoperatively and compared according to follow-up timing, technique, medical treatment and demographics. Statistical analysis included 187 patients. Mean follow-up was 3.8 ± 2.9 years. Both at 30 days and 6 months postoperatively, CGQL, its items and OQH increased significantly (p
Published: 2020

26. Minimal open access ileocolic resection in complicated Crohn’s disease of the terminal ileum

Author: Livia Biancone, L Fazzolari, Giuseppe S. Sica, C. Arcudi, Maurizio Cardi, Giovanni Monteleone, Simone Sibio, Stefano D’Ugo, Sara Di Carlo, and Leandro Siragusa
Subjects: Laparoscopic surgery, medicine.medical_specialty, Article Subject, medicine.medical_treatment, RC799-869, Resection, 03 medical and health sciences, 0302 clinical medicine, Blood loss, medicine, Terminal ileum, Crohn's disease, Hepatology, business.industry, Gastroenterology, Diseases of the digestive system. Gastroenterology, medicine.disease, ileocolic resection, Surgery, Settore MED/18, Minimal open access surgery, Ileocolic resection, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Minimal open access surgery, Crohn's disease, ileocolic resection, Operative time, 030211 gastroenterology & hepatology, business, Research Article
Abstract: The objective of this study was to evaluate the possibility to undertake an ileocolic resection in complex Crohn’s disease using a minimal open abdominal access using standard laparoscopic instruments. The incision was carried out over the previous McBurney scar, with a mean length of 6 cm. Seventy-two patients with complicated Crohn’s disease underwent IC resection in the considered period; 12 patients had a McBurney scar due to a previous appendectomy and represented the group of study. Feasibility and safety of the procedure were evaluated. Clinical data and outcome were compared with a control arm of 15 patients who had a standard laparoscopic IC resection, pooled out from our database among those who had a McBurney incision as service incision. Mean operative time and postoperative stay were significantly shorter in the study group. Blood loss and operative costs were also lower in the study group but did not reach statistical significance. Minimal open access ileocolic resection (MOAIR) through a small McBurney incision seems safe and feasible in complex Crohn’s disease. Some advantages over standard laparoscopic surgery could be found in surgical outcomes and costs.
Published: 2020

27. Apparent diffusion coefficient magnetic resonance imaging (ADC-MRI) in the axillary breast cancer lymph node metastasis detection: a narrative review

Author: Alessandra Splendiani, Alfredo Clemente, Federico Bruno, Salvatore Cappabianca, Ernesto Di Cesare, Alessandra Di Sibio, Pierpaolo Palumbo, Alberto Bafile, Francesco Arrigoni, Camilla De Cataldo, Antonio Barile, Giovanni Luca Gravina, and Carlo Masciocchi
Subjects: medicine.medical_specialty, medicine.diagnostic_test, Axillary lymph nodes, business.industry, Sentinel lymph node, Magnetic resonance imaging, medicine.disease, Occult, 030218 nuclear medicine & medical imaging, Review Article on Multimodality Advanced Imaging and Intervention in Gland Disease, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Breast cancer, 030220 oncology & carcinogenesis, Biopsy, medicine, Breast MRI, Surgery, Radiology, business, Lymph node
Abstract: The presence of axillary lymph nodes metastases in breast cancer is the most significant prognostic factor, with a great impact on morbidity, disease-related survival and management of oncological therapies; for this reason, adequate imaging evaluation is strictly necessary. Physical examination is not enough sensitive to assess breast cancer nodal status; axillary ultrasonography (US) is commonly used to detect suspected or occult nodal metastasis, providing exclusively morphological evaluation, with low sensitivity and positive predictive value. Currently, sentinel lymph node biopsy (SLNB) and/or axillary dissection are the milestone for the diagnostic assessment of axillary lymph node metastases, although its related morbidity. The impact of magnetic resonance imaging (MRI) in the detection of nodal metastases has been widely investigated, as it continues to represent the most promising imaging modality in the breast cancer management. In particular, diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) values represent additional reliable non-contrast sequences, able to improve the diagnostic accuracy of breast cancer MRI evaluation. Several studies largely demonstrated the usefulness of implementing DWI/ADC MRI in the characterization of breast lesions. Herein, in the light of our clinical experience, we perform a review of the literature regarding the diagnostic performance and accuracy of ADC value as potential pre-operative tool to define metastatic involvement of nodal structures in breast cancer patients. For the purpose of this review, PubMed, Web of Science, and SCOPUS electronic databases were searched with different combinations of "axillary lymph node", "breast cancer", "MRI/ADC", "breast MRI" keywords. All original articles, reviews and metanalyses were included.
Published: 2020

28. Pharmacological stress, rest perfusion and delayed enhancement cardiac magnetic resonance identifies very early cardiac involvement in systemic sclerosis patients of recent onset

Author: Antonio Gennarelli, Roberto Giacomelli, Alessandra Splendiani, Francesco Carubbi, Carlo Masciocchi, Paola Di Benedetto, Vasiliki Liakouli, Paola Cipriani, Giuliana Guggino, Ganna D. Radchenko, Francesco Ciccia, Ernesto Di Cesare, Piero Ruscitti, Giovanni Triolo, Alessandra Di Sibio, Onorina Berardicurti, Giacomelli, R., Di Cesare, E., Cipriani, P., Ruscitti, P., Di Sibio, A., Liakouli, V., Gennarelli, A., Carubbi, F., Splendiani, A., Berardicurti, O., Di Benedetto, P., Ciccia, F., Guggino, G., Radchenko, G., Triolo, G., Masciocchi, C., Giacomelli, Roberto, Di Cesare, Ernesto, Cipriani, Paola, Ruscitti, Piero, Di Sibio, Alessandra, Liakouli, Vasiliki, Gennarelli, Antonio, Carubbi, Francesco, Splendiani, Alessandra, Berardicurti, Onorina, Di Benedetto, Paola, Ciccia, Francesco, Guggino, Giuliana, Radchenko, Ganna, Triolo, Giovanni, and Masciocchi, Carlo
Subjects: Adult, Male, medicine.medical_specialty, Adenosine, Heart disease, Heart Diseases, Vasodilator Agents, Contrast Media, Magnetic Resonance Imaging, Cine, Asymptomatic, Cardiac magnetic resonance imaging with pharmacological stress, Myocardial perfusion defect, Systemic sclerosis, Systemic sclerosis heart involvement, Rheumatology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Myocardial perfusion imaging, Coronary circulation, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, Coronary Circulation, Multidetector Computed Tomography, medicine, Humans, 030203 arthritis & rheumatology, Scleroderma, Systemic, medicine.diagnostic_test, business.industry, Microcirculation, Myocardial Perfusion Imaging, medicine.disease, myocardial perfusion defect, Settore MED/16 - Reumatologia, medicine.anatomical_structure, Early Diagnosis, Ventricle, cardiac magnetic resonance imaging with pharmacological stre, Asymptomatic Diseases, systemic sclerosis heart involvement, Female, Radiology, medicine.symptom, business, Perfusion, systemic sclerosi, Rheumatism
Abstract: Objective To evaluate occult cardiac involvement in asymptomatic systemic sclerosis (SSc) patients by pharmacological stress, rest perfusion and delayed enhancement cardiac magnetic resonance (CMR), for a very early identification of patients at higher risk of cardiac-related mortality. Methods Sixteen consecutive patients with definite SSc, fulfilling the American College of Rheumatology/European League Against Rheumatism 2013 classification criteria in less than 1 year from the onset of Raynaud's phenomenon, underwent pharmacological stress, rest perfusion and delayed enhancement CMR. At enrollment, no patient showed signs and/or symptoms suggestive for cardiac involvement. No patient showed traditional cardiovascular risk factors. Both the 12-lead electrocardiogram examination and echocardiographic evaluation did not show any alterations in our cohort. Results Stress perfusion defects of left ventricle were detected in six out of 16 (37.5%) patients and these defects did not match with the coronary flow distribution. The results showed the presence of two different patterns of stress perfusion defects: sub-endocardial and/or a midmyocardial. The presence of stress perfusion defects did not correlate with any clinical feature of enrolled patients. Conclusion Myocardial stress perfusion defects may be detected early by pharmacological stress perfusion CMR, a reliable and sensitive technique for the noninvasive evaluation of SSc heart disease, in patients with SSc of recent onset. These defects seem to be independent from traditional risk factors and associated comorbidities, suggesting they are a specific hallmark of the disease.
Published: 2017

29. A new electronic system prototype for bolometric diagnostic based on metal foils on FTU device

Author: A. Sibio, G. Apruzzese, V. Piergotti, A. Grosso, G. Rocchi, Chiara Monti, Carlo Neri, B. Tilia, F. Pollastrone, Apruzzese, G., Neri, C., Monti, C., Pollastrone, F., Grosso, A., Piergotti, V., Rocchi, G., Sibio, A., and Tilia, B.
Subjects: architecture, Materials science, Detector control systems (detector and experiment monitoring and slow-control systems, architecture, hardware, algorithms, databases), business.industry, Nuclear instruments and methods for hot plasma diagnostics, Detector control systems (detector and experiment monitoring and slow-control systems, Bolometer, algorithms, law.invention, Metal, law, Front-end electronics for detector readout, visual_art, visual_art.visual_art_medium, hardware, Optoelectronics, databases), business, Instrumentation, Electronic systems, Mathematical Physics
Abstract: Measurements of total radiated power are very important in tokamak plasmas, especially in the divertor region where they are required for heat flux active control. Bolometric detectors based on metal foils are used as sensors. The signal readout is provided by an electronic system which drives processes and acquires the signals from the resistive bridge-based bolometer. A project for a new electronic system is being carried on at ENEA Frascati Laboratories, aimed to develop an architecture and a system sufficiently flexible in order to be applied to large fusion devices, such as DTT and ITER. The project, conceived for high reliability and lasting time levels, is based on FPGA boards and a completely digital lock-in. A prototype has been recently tested both in the laboratory and on FTU plasma. A key point of the project is the capability of on-line calibration. The paper describes the architecture of the project for the bolometric diagnostic and the analysis of the first results on FTU plasma.
Published: 2020

30. Advanced neuroimaging of carbon monoxide poisoning

Author: Giorgia Saltelli, Marco Varrassi, Carlo Masciocchi, Alessandra Di Sibio, Alessandra Splendiani, Marco Perri, and Camilla Gianneramo
Subjects: Male, leukoencephalopathy, medicine.medical_specialty, Brain CO poisoning, Neuroimaging, Diagnosis, Differential, White matter, Leukoencephalopathy, Carbon Monoxide Poisoning, 03 medical and health sciences, 0302 clinical medicine, Late phase, Internal medicine, medicine, Medical imaging, Humans, Radiology, Nuclear Medicine and imaging, diffusion magnetic resonance imaging, Brain Imaging, medicine.diagnostic_test, business.industry, Carbon monoxide poisoning, 030208 emergency & critical care medicine, Magnetic resonance imaging, magnetic resonance spectroscopy, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Tissue oxygenation, Cardiology, Neurology (clinical), Tomography, X-Ray Computed, business, 030217 neurology & neurosurgery
Abstract: Carbon monoxide (CO) inhalation is nowadays the most common cause of fatal poisoning worldwide. CO binds to haemoglobin 230–270 times more avidly than oxygen, thus leading to formation of carboxyhaemoglobin with subsequent reduction of tissue oxygenation. Brain is mainly affected due to its high oxygen requirement. Up to two-thirds of patients who survive the acute phase of this pathology present a delayed leukoencephalopathy, usually in a period ranging from two to 40 days. White matter damage closely relates to long-term prognosis of these patients. On the other hand CO seems to play a fundamental role as a possible neuro-protective agent in ischaemic stroke. Diagnostic imaging, with computed tomography and magnetic resonance imaging, especially magnetic resonance spectroscopy, is very useful to depict the presence and extension of this pathology, in both acute and late phase. Nevertheless, a correlation of imaging studies with clinical history and laboratory data is fundamental to perform the correct diagnosis. The purpose of this article is to highlight the imaging features of brain CO poisoning in acute and late phase, describing a case report of a 56-year-old man found unconscious at home.
Published: 2017

31. Injury patterns and causes of death in 953 patients with penetrating abdominal war wounds in a civilian independent non-governmental organization hospital in Lashkargah, Afghanistan

Author: Maurizio Cardi, Antonio Rainone, Simone Sibio, Shah Wali Alizai, Giuseppe La Torre, Giuseppe S. Sica, Michela Paschetto, Ludovica Carbonari, Valentina Mingarelli, Marco Garatti, Andrea Mingoli, Hamayoun Mohammad, Khushal Ibrahim, and Francesco Di Marzo
Subjects: Male, War damage control, Poison control, Wounds, Penetrating, Abdominal Injuries, Occupational safety and health, Injury Severity Score, 0302 clinical medicine, Cause of Death, Abdomen, Epidemiology, Odds Ratio, Medicine, 030212 general & internal medicine, Child, education.field_of_study, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Gastrointestinal war injuries, Penetrating abdominal injuries, Middle Aged, Child, Preschool, Emergency Medicine, Female, Research Article, Adult, Warfare, medicine.medical_specialty, Abdominal war wounds, Adolescent, Population, lcsh:Surgery, Statistics, Nonparametric, 03 medical and health sciences, Injury prevention, Humans, Stab wound, education, Aged, Retrospective Studies, Organizations, business.industry, Afghanistan, 030208 emergency & critical care medicine, lcsh:RD1-811, lcsh:RC86-88.9, medicine.disease, Triage, Settore MED/18, ROC Curve, Emergency medicine, Surgery, business, penetrating abdominal injuries, abdominal war wounds, war damage control, gastrointestinal war injuries
Abstract: BackgroundManagement of penetrating abdominal war injuries centers upon triage, echeloned care, and damage control. A civilian hospital based in a war zone can rarely rely upon these principles because it normally has limited resources and lacks rapid medical evacuation. We designed this study to describe organ injury patterns and factors related to mortality in patients with penetrating abdominal war injuries in a civilian hospital in an active war zone in Afghanistan, examine how these findings differ from those in a typical military setting, and evaluate how they might improve patients’ care.MethodsWe reviewed the records of all patients admitted at the Lashkargah “Emergency” hospital with penetrating abdominal injuries treated from January 2006 to December 2016. Demographic and clinical data were recorded; univariate and multivariate analyses were used to identify variables significantly associated with death.ResultsWe treated 953 patients for penetrating abdominal injury. The population was mainly civilian (12.1% women and 21% under 14). Mean age was 23 years, and patients with blast injuries were younger than in the other groups. The mechanism of injury was bullet injury in 589 patients, shell injury in 246, stab wound in 97, and mine injury in 21. The most frequent abdominal lesion was small bowel injury (46.3%). Small and large bowel injuries were the most frequent in the blast groups, stomach injury in stab wounds. Overall mortality was 12.8%. Variables significantly associated with death were age > 34 years, mine and bullet injury, length of stay, time since injury > 5 h, injury severity score > 17, and associated injuries.ConclusionsEpidemiology and patterns of injury in a civilian hospital differ from those reported in a typical military setting. Our population is mainly civilian with a significant number of women and patients under 14 years. BI are more frequent than blast injuries, and gastrointestinal injuries are more common than injuries to solid organs. In this austere setting, surgeons need to acquire a wide range of skills from multiple surgical specialties. These findings might guide trauma and general surgeons treating penetrating abdominal war wounds to achieve better care and outcome.
Published: 2019

32. MR imaging of cerebral involvement of Rosai-Dorfman disease: a single-centre experience with review of the literature

Author: Carlo Masciocchi, Emanuele Tommasino, Federico Bruno, Marco Varrassi, Giorgia Saltelli, Antonella Corridore, Alessandra Splendiani, Alessandra Di Sibio, and Ernesto Di Cesare
Subjects: Adult, Male, medicine.medical_specialty, Contrast Media, Disease, RDD, 030218 nuclear medicine & medical imaging, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Imaging, Three-Dimensional, Cervical lymphadenopathy, medicine, Humans, Radiology, Nuclear Medicine and imaging, Rosai–Dorfman disease, Spectroscopy, Neuroradiology, Aged, Retrospective Studies, medicine.diagnostic_test, business.industry, Interventional radiology, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Iopamidol, Histiocytosis, 030220 oncology & carcinogenesis, Etiology, Radiology, MRI, Differential diagnosis, medicine.symptom, Histiocytosis, Sinus, business, Tomography, X-Ray Computed
Abstract: Rosai-Dorfman disease (RDD) is a rare, benign, non-Langerhans cells histiocytosis with massive lymphadenopathy of uncertain aetiology. It is commonly characterized by massive, painless, non-tender, bilateral cervical lymphadenopathy. Extra-nodal involvement is usually seen in 50% of patients, with the brain being affected in only 5% of cases, usually as dural-based lesions. Clinical presentation is heterogeneous and strongly dependent on the localization of the lesions. Although the histopathological findings are essential for the final diagnosis, brain magnetic resonance imaging (MRI) currently represents the first-line strategy for the detection of the lesions across the central nervous system (CNS); moreover, it may provide additional elements for the differential diagnosis versus other more common lesions. We performed a case-based literature review to highlight possible aetiologic and pathogenetic theories of this disease, along with imaging features of RDD, with a particular focus on the MRI characteristics of the CNS involvement (CNS-RDD). Finally, we provided a novel insight on the current therapeutic approaches, either surgical or medical.
Published: 2019

33. Histotype influences emergency presentation and prognosis in colon cancer surgery

Author: Simone Sibio, L Cinelli, V Bellato, Vincenzo Formica, G Bagaglini, S. Di Carlo, A. Di Giorgio, Giampiero Palmieri, Stefano D’Ugo, Bruno Sensi, and Giuseppe S. Sica
Subjects: Male, medicine.medical_specialty, Emergency Medical Services, Colorectal cancer, Colon, medicine.medical_treatment, 030230 surgery, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Colon cancer, Elective, Emergency, Mucinous cancer, Surgery, Internal medicine, medicine, Humans, Prospective Studies, Stage (cooking), Laparoscopy, colon cancer, emergency, elective, surgery, mucinous cancer, Lymph node, Colectomy, Aged, Neoplasm Staging, Retrospective Studies, medicine.diagnostic_test, business.industry, Signet ring cell, Cancer, medicine.disease, Prognosis, Adenocarcinoma, Mucinous, Settore MED/18, Survival Rate, medicine.anatomical_structure, Elective Surgical Procedures, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Colonic Neoplasms, Female, business, Carcinoma, Signet Ring Cell, Abdominal surgery
Abstract: To investigate whether differences in histotype in colon cancer correlate with clinical presentation and if they might influence oncological outcomes and survival. Data regarding colon cancer patients operated both electively or in emergency between 2009 and 2014 were retrospectively collected from a prospectively maintained database and analyzed for the purpose of this study. Rectal cancer was excluded from this analysis. Statistical univariate and multivariate analyses were performed to investigate possible significant variables influencing clinical presentation, as well as oncological outcomes and survival. Data from 219 patients undergoing colorectal resection for cancer of the colon only were retrieved. One hundred seventy-four patients had an elective procedure and forty-five had an emergency colectomy. Emergency presentation was more likely to occur in mucinous (p < 0.05) and signet ring cell (p < 0.01) tumors. No definitive differences in 5-year overall (44.7% vs. 60.6%, p = 0.078) and disease-free (51.2% vs. 64.4%, p = 0.09) survival were found between the two groups as a whole, but the T3 emergency patients showed worse prognosis than the elective (p < 0.03). Lymph node invasion, laparoscopy, histology, and blood transfusions were independent variables found to influence survival. Distribution assessed for pTNM stage showed T3 cancers were more common in emergency (p < 0.01). Mucinous and signet ring cell tumors are related to emergency presentation, pT3 stage, poorest outcomes, and survival. Disease-free survival in patients who had emergency surgery for T3 colon cancer seems related to the histotype.
Published: 2019

34. Triiodothyronine (T3) upregulates the expression of proto-oncogene TGFA independent of MAPK/ERK pathway activation in the human breast adenocarcinoma cell line, MCF7

Author: Vickeline Namba, Sarah M. B. Costa, Maria Tereza Nunes, Diego A. M. Oliveira, Miriane de Oliveira, Fernanda Cristina Fontes Moretto, Maria Teresa De Sibio, Bianca Mariani Gonçalves, Célia Regina Nogueira, Tabata Marinda da Silva, Regiane Marques Castro Olimpio, Igor Carvalho Deprá, Universidade Estadual Paulista (Unesp), and Universidade de São Paulo (USP)
Subjects: MAPK/ERK pathway, TGF alpha, MAP Kinase Signaling System, Endocrinology, Diabetes and Metabolism, lcsh:Medicine, Breast Neoplasms, 030209 endocrinology & metabolism, RNA polymerase II, Adenocarcinoma, Proto-Oncogene Mas, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Cell Line, Tumor, Proto-Oncogenes, Gene expression, Humans, Medicine, RNA, Messenger, Regulation of gene expression, Messenger RNA, lcsh:RC648-665, biology, Oncogene, business.industry, lcsh:R, RNA, Transforming Growth Factor alpha, Molecular biology, Gene Expression Regulation, Neoplastic, Thyroid hormone, stomatognathic diseases, 030220 oncology & carcinogenesis, MCF-7 Cells, nongenomic actions, gene expression, biology.protein, Triiodothyronine, Female, business
Abstract: Made available in DSpace on 2019-10-06T15:44:33Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-05-01. Added 1 bitstream(s) on 2019-10-09T18:34:54Z : No. of bitstreams: 1 S2359-39972019000200142.pdf: 239355 bytes, checksum: bb698bc40f032f4356658ecb11d9c169 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objective: To verify the physiological action of triiodothyronine T3 on the expression of transforming growth factor α (TGFA) mRNA in MCF7 cells by inhibition of RNA Polymerase II and the MAPK/ERK pathway. Materials and methods: The cell line was treated with T3 at a physiological dose (10-9M) for 10 minutes, 1 and 4 hour (h) in the presence or absence of the inhibitors, α-amanitin (RNA polymerase II inhibitor) and PD98059 (MAPK/ERK pathway inhibitor). TGFA mRNA expression was analyzed by RT-PCR. For data analysis, we used ANOVA, complemented with the Tukey test and Student t-test, with a minimum significance of 5%. Results: T3 increases the expression of TGFA mRNA in MCF7 cells in 4 h of treatment. Inhibition of RNA polymerase II modulates the effect of T3 treatment on the expression of TGFA in MCF7 cells. Activation of the MAPK/ERK pathway is not required for T3 to affect the expression of TGFA mRNA. Conclusion: Treatment with a physiological concentration of T3 after RNA polymerase II inhibition altered the expression of TGFA. Inhibition of the MAPK/ERK pathway after T3 treatment does not interfere with the TGFA gene expression in a breast adenocarcinoma cell line. Departamento de Medicina Interna Faculdade de Medicina de Botucatu Universidade Estadual Paulista (UNESP) Universidade Estadual Paulista (UNESP) Departamento de Fisiologia e Biofísica Instituto de Ciencias Biomédicas Universidade de São Paulo (USP) Departamento de Medicina Interna Faculdade de Medicina de Botucatu Universidade Estadual Paulista (UNESP) Universidade Estadual Paulista (UNESP) FAPESP: 2013/05629-4 FAPESP: 2014/15209-5 FAPESP: 2015/09686-8
Published: 2019

35. Disruptive Effect of Organotin on Thyroid Gland Function Might Contribute to Hypothyroidism

Author: Bianca Mariani Gonçalves, Regiane Marques Castro Olimpio, Lucas Solla Mathias, Dariane Beatriz Marino Cardoso, Bruna Moretto Rodrigues, Jones Bernardes Graceli, Helena Paim Tilli, Leandro Ceotto Freitas-Lima, Célia Regina Nogueira, Maria Teresa De Sibio, Sarah M. B. Costa, Tabata Marinda da Silva, Miriane de Oliveira, and Fernanda Cristina Fontes Moretto
Subjects: 0301 basic medicine, lcsh:RC648-665, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, Thyroid, Physiology, Review Article, 010501 environmental sciences, 01 natural sciences, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Hypothalamic–pituitary–thyroid axis, Toxicology studies, 03 medical and health sciences, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Medicine, Endocrine system, Thyroid function, business, Homeostasis, Function (biology), 0105 earth and related environmental sciences, Hormone
Abstract: A considerable increase in endocrine abnormalities has been reported over the last few decades worldwide. A growing exposure to endocrine-disrupting chemicals (EDCs) can be one of the causes of endocrine disorders in populations, and these disorders are not only restricted to the metabolic hormone system but can also cause abnormal functions. Thyroid hormone (TH) disruption is defined as an abnormal change in TH production, transport, function, or metabolism, which results in some degree of impairment in body homeostasis. Many EDCs, including organotin compounds (OTCs), are environmental contaminants that are commonly found in antifouling paints used on ships and in several other industrial procedures. OTCs are obesogenic and can disrupt TH metabolism; however, abnormalities in thyroid function resulting from OTC exposure are less well understood. OTCs, one of the most prevalent EDCs that are encountered on a daily basis, modulate the thyroid axis. In most toxicology studies, it has been reported that OTCs might contribute to hypothyroidism.
Published: 2019

36. Surgical treatment of intraperitoneal metastases from lung cancer. Two case reports and a review of the literature

Author: Simone Sibio, Alessandra Di Giorgio, Bianca Maria Sollazzo, Sara Di Carlo, Maurizio Cardi, Paolo Sammartino, and Giuseppe S. Sica
Subjects: Adult, Male, medicine.medical_specialty, Poor prognosis, Lung Neoplasms, lcsh:Medicine, Case Report, 030204 cardiovascular system & hematology, Cytoreductive surgery, Lung cancer, Peritoneal metastases, Carcinoma, Non-Small-Cell Lung, Humans, Intestinal Obstruction, Middle Aged, Peritoneal Neoplasms, Tomography, X-Ray Computed, Cytoreduction Surgical Procedures, 03 medical and health sciences, 0302 clinical medicine, Peritoneum, Surgical oncology, Medicine, Non-Small-Cell Lung, Surgical treatment, Tomography, business.industry, lcsh:R, Carcinoma, General Medicine, medicine.disease, X-Ray Computed, Settore MED/18, Bowel obstruction, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Good prognosis, Radiology, business
Abstract: Background Peritoneal metastases are often reported in several abdominal tumors. Peritoneal diffusion from extra-abdominal tumors is thought to be rare. Lung cancer is one of the most common cancers in the world with early metastases and it is associated with poor prognosis in advanced stages. Peritoneal metastases from lung cancer are uncommon and the real mechanism of its diffusion to the peritoneum is unknown. However, its clinical behavior is similar to any other peritoneal metastasis from abdominal tumors. Case presentation We present two Caucasian patients (a 44-year-old man and a 59-year-old man) with bowel obstruction from peritoneal metastases from non-small cell lung cancer who successfully underwent emergency cytoreductive surgery and had a good prognosis and survival. Conclusions In our patients with isolated peritoneal metastases from lung cancer, cytoreduction showed good prognosis with acceptable morbidity. This treatment option might be considered in highly selected cases to improve survival. Strict follow-up is mandatory to allow early diagnosis of peritoneal diffusion.
Published: 2019

37. 3D Laparoscopy: A Potential Cutting Edge in Minimal Invasive Digestive Surgery

Author: Giuseppe S. Sica, Simone Sibio, and Sara Di Carlo
Subjects: Laparoscopic surgery, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Digestive surgery, medicine.medical_treatment, laparoscopy, Edge (geometry), Surgery, 3d, laparoscopy, digestive surgery, medicine, digestive surgery, Laparoscopy, business, 3d
Published: 2018

38. POS1344 EVALUATING THE MULTIVISCERAL INVOLVEMENT ON ADULT-ONSET STILL’S DISEASE TO RETRIEVE IMAGING-BASED DIFFERENCES IN PATIENTS WITH AND WITHOUT MACROPHAGE ACTIVATION SYNDROME; RESULTS FROM A SINGLE-CENTRE OBSERVATIONAL STUDY

Author: Federico Bruno, Riccardo Monti, Viktoriya Pavlych, I. Di Cola, Piero Ruscitti, Alessandro Conforti, A. Di Sibio, Antonio Barile, Onorina Berardicurti, Carlo Masciocchi, F. Sensini, and Paola Cipriani
Subjects: medicine.medical_specialty, Adult-onset Still's disease, business.industry, Immunology, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Single centre, Rheumatology, Macrophage activation syndrome, Internal medicine, Immunology and Allergy, Medicine, Observational study, In patient, business
Abstract: Background:Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disorder usually affecting young adults, burdened by life-threatening complications, mainly macrophage activation syndrome (MAS), a secondary form of hemophagocytic lymphohistiocytosis [1]. In this context, the importance of an accurate assessment of AOSD is suggested to promptly recognise the multivisceral involvement of the disease which is associated with life-threatening complications. The assessment of the most aggressive subsets of the disease could guide the clinicians when to apply additional resources but avoiding unnecessary expenditures in patients with a less severe clinical picture.Objectives:In this study, we aimed at describing the multivisceral involvement of the disease to retrieve imaging-based differences in AOSD patients with and without MAS.Methods:The present evaluation has been designed as a cross-sectional study to descriptively compare the multivisceral involvement in AOSD patients with and without MAS. Patients admitted to our Institution, who underwent a total body CT scan, were selected from our historical cohort and assessed. Clinical and CT scan characteristics of AOSD patients with and without MAS were compared. Clinical and CT scan characteristics of AOSD patients with and without MAS were analysed by parametric or non-parametric t tests for all continuous variables, and chi squared test was used for categorical ones, as appropriate. Furthermore, possible correlations among radiological outcomes with laboratory markers and systemic score were estimated by using a point-biserial coefficient correlation.Results:This study evaluated 39 AOSD patients (men 64.1%), mean age of 48.8±16.6 years). Out of those, 14 patients (35.9%) were complicated by MAS. These patients showed higher values of ferritin [AOSD: 770.0 (1306.5) ng/mL vs MAS: 2926.3 (4918.5) ng/mL p=0.003] and systemic score (AOSD: 4.6±1.4 vs MAS: 6.9±1.7, pConclusion:Our findings showed a higher prevalence of multiorgan involvement in AOSD patients with MAS, suggesting imaging-based differences, although other studies are needed to fully assess this issue. Pulmonary disease, hepatomegaly, splenomegaly, lymph nodes enlargement, and abdominal effusions were associated with these more aggressive patients.References:[1]Giacomelli R, Ruscitti P, Shoenfeld Y. A comprehensive review on adult onset Still’s disease. J Autoimmun. 2018 Sep;93:24-36.Disclosure of Interests:None declared
Published: 2021

39. Pitfalls and challenges of the purinergic signaling cascade in obesity

Author: Lucas Solla Mathias, José Bernardo Noronha-Matos, Paulo Correia-de-Sá, Maria Teresa De Sibio, Célia Regina Nogueira, Maria Adelina Costa, and Miriane de Oliveira
Subjects: 0301 basic medicine, Adipose Tissue, White, Population, Adipose tissue, Bioinformatics, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, Adipose Tissue, Brown, Adenine nucleotide, Adipocyte, Animals, Humans, Medicine, Obesity, education, Pharmacology, education.field_of_study, Adipogenesis, business.industry, Purinergic receptor, Receptors, Purinergic, Receptors, Purinergic P1, Purinergic signalling, medicine.disease, 030104 developmental biology, chemistry, Purines, 030220 oncology & carcinogenesis, business, Signal Transduction
Abstract: Obesity is a worldwide health problem which have reached pandemic proportions, now also including low and middle-income countries. Excessive or abnormal fat deposition in the abdomen especially in the visceral compartment is tightly associated with a high metabolic risk for arterial hypertension, type II diabetes, cardiovascular diseases, musculoskeletal disorders (especially articular degeneration) and some cancers. Contrariwise, accumulation of fat in the subcutaneous compartment has been associated with a neutral metabolic impact, favoring a lower risk of insulin resistance. Obesity results more often from an avoidable imbalance between food consumption and energy expenditure. There are several recommended strategies for dealing with obesity, including pharmacological therapies, but their success remains incomplete and may not compensate the associated adverse effects. Purinergic signaling operated by ATP and its metabolite, adenosine, has attracted increasing attention in obesity. The extracellular levels of purines often reflect the energy status of a given cell population. Adenine nucleotides and nucleosides fine tuning control adipogenesis and mature adipocytes function via the activation of P2 and P1 purinoceptors, respectively. These features make the purinergic signaling cascade a putative target for therapeutic intervention in obesity and related metabolic syndromes. There are, however, gaps in our knowledge regarding the role of purines in adipocyte precursors differentiation and mature adipocytes functions, as well as their impact among distinct adipose tissue deposits (e.g. white vs. brown, visceral vs. subcutaneous), which warrants further investigations before translation to clinical trials can be made.
Published: 2020

40. Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome

Author: Regiane Marques Castro Olimpio, Gláucia Maria Ferreira da Silva Mazeto, Maria Teresa De Sibio, Antonio Carlos Cicogna, Miriane de Oliveira, Renata de Azevedo Melo Luvizotto, Dijon Henrique Salomé de Campos, Denise Perone, Célia Regina Nogueira, Carlos Roberto Padovani, Fábio V. G. Campanha, Fernanda Cristina Fontes Moretto, Universidade Estadual Paulista (Unesp), and Universidade Federal de Mato Grosso (UFMT)
Subjects: Male, 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Gene Expression, heart failure, lcsh:Medicine, Heart failure, 030204 cardiovascular system & hematology, Ryanodine receptor 2, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Sarcoplasmic Reticulum Calcium-Transporting ATPases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine.artery, calcium channels, triiodothyronine, medicine, Animals, Thoracic aorta, RNA, Messenger, Thoracotomy, Rats, Wistar, Triiodothyronine, lcsh:RC648-665, business.industry, lcsh:R, Therapeutic use, Ryanodine Receptor Calcium Release Channel, Reverse triiodothyronine, Aortic Valve Stenosis, medicine.disease, Euthyroid Sick Syndromes, Thyroxine, Calcium channels, 030104 developmental biology, Endocrinology, chemistry, Aortic valve stenosis, therapeutic use, Models, Animal, business, Euthyroid sick syndrome
Abstract: Made available in DSpace on 2018-12-11T17:08:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-01. Added 1 bitstream(s) on 2019-10-09T18:30:42Z : No. of bitstreams: 1 S2359-39972016000600582.pdf: 208346 bytes, checksum: d4024e8a967f9479c5370d43b346a841 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objective: The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological doses. Materials and methods: HF was induced in 18 male Wistar rats by clipping the ascending thoracic aorta to generate aortic stenosis (HFS group), while the control group (9-sham) underwent thoracotomy. After 21 weeks, the HFS group was subdivided into two subgroups. One group (9 Wistar rats) with HF received 1.0 µg of T4/100 g of body weight for five consecutive days (HFS/T4); the other group (9 Wistar rats) received isotonic saline solution (HFS/S). The animals were sacrificed after this treatment and examined for signs of HF. Samples from the left ventricles of these animals were analyzed by RT-qPCR for the expression of Serca2 and Ryr2 genes. Results: Rats with HF developed euthyroid sick syndrome (ESS) and treatment with T4 restored the T3 values to the Sham level and increased Serca2 and Ryr2 gene expression, thereby demonstrating a possible benefit of T4 treatment for heart function in ESS associated with HF. Conclusion: The T4 treatment can potentially normalize the levels of T3 as well elevated Serca2 and Ryr2 gene expression in the myocardium in heart failure rats with euthyroid sick syndrome. Departamento de Clínica Médica Unidade de Pesquisa Experimental (Unipex) Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp) Instituto de Ciências da Saúde Universidade Federal de Mato Grosso (UFMT) Departamento de Bioestatística Instituto de Biociências Universidade Estadual Paulista (Unesp) Departamento de Clínica Médica Unidade de Pesquisa Experimental (Unipex) Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp) Departamento de Bioestatística Instituto de Biociências Universidade Estadual Paulista (Unesp) FAPESP: 2007/55902-8
Published: 2016

41. 320-row coronary computed tomography angiography (CCTA) with automatic exposure control (AEC): effect of 100 kV versus 120 kV on image quality and dose exposure

Author: Giovanni Luca Gravina, Carlo Masciocchi, Alessandra Splendiani, Antonio Gennarelli, Valentina Felli, Ernesto Di Cesare, Marco Perri, Alessandra Di Sibio, and Antonio Barile
Subjects: Male, medicine.medical_specialty, Computed Tomography Angiography, Image quality, Cardiac-Gated Imaging Techniques, Contrast Media, Coronary Disease, Signal-To-Noise Ratio, Radiation Dosage, Effective dose (radiation), Noise (electronics), 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Contrast-to-noise ratio, Nuclear Medicine and Imaging, Triiodobenzoic Acids, medicine, Humans, Radiology, Nuclear Medicine and imaging, Automatic exposure control, Computed tomography angiography, medicine.diagnostic_test, business.industry, Radiation dose, Ultrasound, General Medicine, Middle Aged, 320-row coronary computed tomography angiography (CCTA), Signal-to-noise ratio (imaging), Tube voltage, Radiology, Nuclear Medicine and Imaging, 030220 oncology & carcinogenesis, Radiographic Image Interpretation, Computer-Assisted, Female, Radiology, business, Nuclear medicine
Abstract: To compare the impact of a 100 kV tube voltage protocol to 120 kV in terms of image quality and radiation dose by a 320 row coronary computed tomography angiography (CCTA) with automatic exposure control (AEC). Using a propensity matched analysis we compared a group of 135 patients scanned using a 100 kV tube voltage protocol with a group of 135 subjects scanned employing a 120 kV tube voltage setting. In all subjects the heart rate (HR) was
Published: 2016

42. Ileo-ileal Intussusception Caused by Primary Monophasic Synovial Sarcoma (SS) of the Ileum

Author: Claudia Marsecano, V. Vellucci, Antonio Gennarelli, Carlo Masciocchi, Marco Perri, Valentina Felli, Alessandra Splendiani, G. F. Sanzà, A. Di Sibio, E. Di Cesare, Irene Amicarelli, and Giulia Michelini
Subjects: Leiomyosarcoma, medicine.medical_specialty, Gastrointestinal tract, Environmental Engineering, business.industry, medicine.disease, Malignancy, Gastroenterology, Industrial and Manufacturing Engineering, Synovial sarcoma, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Intussusception (medical disorder), Monophasic Synovial Sarcoma, medicine, 030211 gastroenterology & hepatology, Sarcoma, Differential diagnosis, business
Abstract: Synovial Sarcoma (SS) is an uncommon neoplasm, very rare in gastrointestinal tract. We report a case of 57 years old man who reported a previous diagnosis of primary left atrial leiomyosarcoma referred for a follow-up CT, that showed findings compatible with ileo-ileal intussusception. The patient underwent surgical resection and pathological analysis showed that the lead point of intussusception were two polypoid lesions referable to SS. The present case report suggests that, although the incidence of SS is rare, it should be considered in the differential diagnosis of any gastrointestinal non-epithelial malignancy. Case Study Cesare et al.; BJMMR, 11(7): 1-7, 2016; Article no.BJMMR.21438 2
Published: 2016

43. Correction to: MR imaging of cerebral involvement of Rosai–Dorfman disease: a single-centre experience with review of the literature

Author: Marco Varrassi, Giorgia Saltelli, Antonella Corridore, Carlo Masciocchi, Emanuele Tommasino, Ernesto Di Cesare, Federico Bruno, Alessandra Di Sibio, and Alessandra Splendiani
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Interventional radiology, General Medicine, medicine.disease, Mr imaging, Single centre, medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Rosai–Dorfman disease, Neuroradiology
Abstract: In the original publication, the first and last name of the Author “Giorgia Saltelli” was inadvertently swapped. The correct Author group has been provided below.
Published: 2020

44. Graves’ ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-alpha gene expression in orbital fibroblasts

Author: Sueli A. Clara, Vania dos Santos Nunes, Sandro José Conde, Maria Teresa De Sibio, Célia Regina Nogueira, Edson Nacib Jorge, Renata de Azevedo Melo Luvizotto, Gláucia Maria Ferreira da Silva Mazeto, Miriane de Oliveira, Sarah Santiloni Cury, Universidade Estadual Paulista (Unesp), and Ciência e Tecnologia do Estado de São Paulo (IFSP)
Subjects: medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Retinoic acid, lcsh:Medicine, Inflammation, Severity of Illness Index, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Dexamethasone, Graves' ophthalmopathy, chemistry.chemical_compound, Adipocyte, Internal medicine, Receptors, retinoic acid, Humans, Medicine, Retinoid, Fibroblast, Glucocorticoids, lcsh:RC648-665, business.industry, Retinoic Acid Receptor alpha, lcsh:R, graves ophthalmopathy, Graves ophthalmopathy, Fibroblasts, medicine.disease, eye diseases, Endocrinology, medicine.anatomical_structure, chemistry, gene expression, Gene expression, medicine.symptom, business, Orbit, hormones, hormone substitutes, and hormone antagonists, Glucocorticoid, medicine.drug
Abstract: Made available in DSpace on 2018-12-11T17:21:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-01. Added 1 bitstream(s) on 2019-10-09T18:31:56Z : No. of bitstreams: 1 S2359-39972018000300366.pdf: 123932 bytes, checksum: 884f7b3ea5771ca0dc08ec15ac8f5036 (MD5) Made available in DSpace on 2018-12-11T17:21:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-01. Added 1 bitstream(s) on 2019-10-09T18:31:56Z : No. of bitstreams: 1 S2359-39972018000300366.pdf: 123932 bytes, checksum: 884f7b3ea5771ca0dc08ec15ac8f5036 (MD5) Made available in DSpace on 2018-12-11T17:21:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-01. Added 1 bitstream(s) on 2019-10-09T18:31:56Z : No. of bitstreams: 1 S2359-39972018000300366.pdf: 123932 bytes, checksum: 884f7b3ea5771ca0dc08ec15ac8f5036 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objective: Graves’ ophthalmopathy (GO) is an autoimmune disease that leads to ocular proptosis caused by fat accumulation and inflammation, and the main treatment is corticosteroid therapy. Retinoid acid receptor-alpha (RARα) seems to be associated with inflammation and adipocyte differentiation. This study aimed to assess the effect of glucocorticoid treatment on orbital fibroblasts of GO patient treated or not with different glucocorticoid doses. Materials and methods: Orbital fibroblasts collected during orbital decompression of a female patient with moderately severe/severe GO were cultivated and treated with 10 nM and 100 nM dexamethasone (Dex). RARα gene expression in the treated and untreated cells was then compared. Results: Fibroblast RARα expression was not affected by 100 nM Dex. On the other hand, RARα expression was 24% lower in cells treated with 10 nM Dex (p < 0.05). Conclusions: Orbital fibroblasts from a GO patient expressed the RARα gene, which was unaffected by higher, but decreased with lower doses of glucocorticoid. Divisão de Endocrinologia Departamento de Medicina Interna Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo (Unesp) Instituto Federal de Educação Ciência e Tecnologia do Estado de São Paulo (IFSP) Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo (Unesp) Divisão de Endocrinologia Departamento de Medicina Interna Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo (Unesp) Departamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeça e Pescoço Faculdade de Medicina de Botucatu Universidade Estadual de São Paulo (Unesp) FAPESP: #:03/03651-0 FAPESP: 2011/18464-8
Published: 2018

45. A case of intrasplenic displacement of an endoscopic double-pigtail stent as a treatment for laparoscopic sleeve gastrectomy leak

Author: Michele, Marchese, Lucia, Romano, Antonio, Giuliani, Giovanni, Cianca, Alessandra, Di Sibio, Francesco, Carlei, Gianfranco, Amicucci, and Mario, Schietroma
Subjects: medicine.medical_specialty, Leak, Gastric leak, medicine.medical_treatment, Pigtail, 030209 endocrinology & metabolism, Abdominal cavity, Article, 03 medical and health sciences, 0302 clinical medicine, Case report, medicine, Double pigtail stent, Internal drainage, Displacement (orthopedic surgery), Abscess, Laparoscopic sleeve gastrectomy, business.industry, Stent, medicine.disease, Surgery, medicine.anatomical_structure, Intrasplenic migration, 030211 gastroenterology & hepatology, Complication, business
Abstract: Highlights • The most frequent and severe complication after laparoscopic sleeve gastrectomy is gastric leak. • The endoscopic placement of a double-pigtail drain across the leak has been proven to be effective and minimally invasive. • Drain’s migration into the abdominal cavity is not common and its intrasplenic displacement is even more rare. • Pigtail drain migration involving the spleen may expose the patient to the risk of parenchymal abscess or haemorrhage., Introduction The most frequent and severe complication after laparoscopic sleeve gastrectomy is gastric leak. Nowadays, there is no specific standard recommendation for its management, but the endoscopic placement of a double-pigtail drain across the leak has been proven to be effective and minimally invasive. Stent displacement into the abdominal cavity is not common and intrasplenic migration is even more rare. Case presentation We report a case of a 49-year-old woman with intrasplenic displacement of an endoscopic double-pigtail stent as a treatment for laparoscopic sleeve gastrectomy leak. Discussion Pigtail drain migration involving the spleen is rare but may potentially expose the patient to the risk of parenchymal abscess or haemorrhage. Often the clinic does not indicate early this complication. Conclusion We underline the need for a close radiologic follow-up, regardless of clinical conditions, in all patients treated with double-pigtail drain and its early removal in case of migration.
Published: 2018

46. Progressive Multifocal Leukoencephalopathy following Treatment with Rituximab in an HIV-Negative Patient with Non-Hodgkin Lymphoma

Author: Alessandra Di Sibio, Monica Anselmi, Alessandra Splendiani, Alessia Catalucci, Patrizia Sucapane, Carmine Marini, Antonio Gennarelli, Valentina Felli, and Massimo Gallucci
Subjects: Pathology, medicine.medical_specialty, Cyclophosphamide, medicine.medical_treatment, JC virus, Antineoplastic Agents, medicine.disease_cause, Antineoplastic Combined Chemotherapy Protocols, medicine, Demyelinating disease, Humans, Radiology, Nuclear Medicine and imaging, business.industry, Lymphoma, Non-Hodgkin, Progressive multifocal leukoencephalopathy, Leukoencephalopathy, Progressive Multifocal, Brain, Immunosuppression, Original Articles, General Medicine, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Lymphoma, Doxorubicin, Vincristine, Prednisolone, Prednisone, Female, Rituximab, Neurology (clinical), Tomography, X-Ray Computed, business, medicine.drug
Abstract: Progressive multifocal leukoencephalopathy (PML) is a rare rapidly progressive demyelinating disease of the central nervous system caused by reactivation of latent John Cunningham (JC) polyomavirus (JCV) infection. We describe an unusual case of PML in a 54-year-old patient with follicular non-Hodgkin lymphoma who received rituximab plus cyclophosphamide, hydroxydaunorubicin, oncovicin and prednisolone (R-CHOP) therapy. She started to notice gradual progressive neurological symptoms about two months after completion of rituximab treatment and was therefore admitted to hospital. On admission, brain CT and MRI showed widespread lesions consistent with a demyelinating process involving the subcortical and deep white matter of the cerebral and cerebellar hemispheres. CT and MRI findings were suggestive of PML, and JC virus DNA was detected by polymerase chain reaction assay of the cerebrospinal fluid and serum. The patient was treated supportively but reported a progressive worsening of the clinical and radiological findings. Our report emphasizes the role of CT and MRI findings in the diagnosis of PML and suggests that PML should be considered in patients with progressive neurological disorders involving the entire nervous system and mainly the white matter, especially in the presence of previous immunomodulatory treatment or immunosuppression.
Published: 2014

47. Evaluation of target coverage and margins adequacy during CyberKnife Lung Optimized Treatment

Author: Marco Riboldi, S. Vigorito, Elena Rondi, Annamaria Ferrari, Filippo de Marinis, Lorenzo Spaggiari, S. Arculeo, C. Francia, Delia Ciardo, Federica Cattani, Gaia Piperno, Matteo Seregni, Maria Alessia Zerella, Rosalinda Ricotti, Barbara Alicja Jereczek-Fossa, Guido Baroni, D. Sibio, and Roberto Orecchia
Subjects: Modality (human–computer interaction), Lung Neoplasms, Middle Lobe, business.industry, Movement, Radiotherapy Planning, Computer-Assisted, Planning target volume, General Medicine, computer.software_genre, Radiosurgery, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Match moving, Voxel, Cyberknife, 030220 oncology & carcinogenesis, Histogram, X ray image, Humans, Four-Dimensional Computed Tomography, Nuclear medicine, business, computer, Mathematics
Abstract: PURPOSE Evaluation of target coverage and verification of safety margins, in motion management strategies implemented by Lung Optimized Treatment (LOT) module in CyberKnife system. METHODS Three fiducial-less motion management strategies provided by LOT can be selected according to tumor visibility in the X ray images acquired during treatment. In 2-view modality the tumor is visible in both X ray images and full motion tracking is performed. In 1-view modality the tumor is visible in a single X ray image, therefore, motion tracking is combined with an internal target volume (ITV)-based margin expansion. In 0-view modality the lesion is not visible, consequently the treatment relies entirely on an ITV-based approach. Data from 30 patients treated in 2-view modality were selected providing information on the three-dimensional tumor motion in correspondence to each X ray image. Treatments in 1-view and 0-view modalities were simulated by processing log files and planning volumes. Planning target volume (PTV) margins were defined according to the tracking modality: end-exhale clinical target volume (CTV) + 3 mm in 2-view and ITV + 5 mm in 0-view. In the 1-view scenario, the ITV encompasses only tumor motion along the non-visible direction. Then, non-uniform ITV to PTV margins were applied: 3 mm and 5 mm in the visible and non-visible direction, respectively. We defined the coverage of each voxel of the CTV as the percentage of X ray images where such voxel was included in the PTV. In 2-view modality coverage was calculated as the intersection between the CTV centred on the imaged target position and the PTV centred on the predicted target position, as recorded in log files. In 1-view modality, coverage was calculated as the intersection between the CTV centred on the imaged target position and the PTV centred on the projected predictor data. In 0-view modality coverage was calculated as the intersection between the CTV centred on the imaged target position and the non-moving PTV. Similar to dose-volume histogram, CTV coverage-volume histograms (defined as CVH) were derived for each patient and treatment modality. The geometric coverages of the 90% and 95% of CTV volume (C90, C95, respectively) were evaluated. Patient-specific optimal margins (ensuring C95 ≥ 95%) were computed retrospectively. RESULTS The median ± interquartile-rage of C90 and C95 for upper lobe lesions was 99.1 ± 0.6% and 99.0 ± 3.1%, whereas they were 98.9 ± 4.2% and 97.8 ± 7.5% for lower and middle lobe tumors. In 2-view, 1-view and 0-view modality, adopted margins ensured C95 ≥ 95% in 70%, 85% and 63% of cases and C95 ≥ 90% in 90%, 88% and 83% of cases, respectively. In 2-view, 1-view and 0-view a reduction in margins still ensured C95 ≥ 95% in 33%, 78% and 59% of cases, respectively. CONCLUSIONS CTV coverage analysis provided an a-posteriori evaluation of the treatment geometric accuracy and allowed a quantitative verification of the adequacy of the PTV margins applied in CyberKnife LOT treatments offering guidance in the selection of CTV margins.
Published: 2017

48. Diagnostic accuracy of proton magnetic resonance spectroscopy and perfusion-weighted imaging in brain gliomas follow-up: A single institutional experience

Author: Carlo Masciocchi, Alessandra Di Sibio, Alessia Catalucci, Giovanni Luca Gravina, Monica Anselmi, V. Vellucci, Ernesto Di Cesare, Valentina Felli, and Mario Di Staso
Subjects: Adult, Male, 1H-MRS, glioma, MRI, perfusion MRI, spectroscopy, Biomarkers, Tumor, Brain Neoplasms, Disease Progression, Echo-Planar Imaging, Female, Glioma, Humans, Magnetic Resonance Imaging, Middle Aged, Neoplasm Grading, Predictive Value of Tests, Proton Magnetic Resonance Spectroscopy, Retrospective Studies, Sensitivity and Specificity, Radiology, Nuclear Medicine and Imaging, Neurology (clinical), Diagnostic accuracy, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Nuclear Medicine and Imaging, medicine, Radiology, Nuclear Medicine and imaging, Tumor, Receiver operating characteristic, business.industry, Area under the curve, General Medicine, Odds ratio, medicine.disease, Proton magnetic resonance, Brain gliomas, business, Nuclear medicine, Radiology, Perfusion, 030217 neurology & neurosurgery, Biomarkers, Imaging of Neoplastic Disease
Abstract: Objectives The objective of this study was to evaluate whether proton magnetic resonance spectroscopy and perfusion magnetic resonance imaging (MRI) are able to increase diagnostic accuracy in the follow-up of brain gliomas, identifying the progression of disease before it becomes evident in the standard MRI; also to evaluate which of the two techniques has the best diagnostic accuracy. Methods Eighty-three patients with cerebral glioma (50 high-grade gliomas (HGGs), 33 low-grade gliomas (LGGs)) were retrospectively enrolled. All patients underwent standard MRI, H spectroscopic and perfusion echo-planar imaging MRI. For spectroscopy variations of choline/creatine, choline/N-acetyl-aspartate ratio, and lipids and lactates peak were considered. For perfusion 2.0 was considered the cerebral blood volume cut-off for progression. The combination of functional parameters gave a multiparametric score (0–2) to predict outcome. Diagnostic performance was determined by the receiver operating characteristic curve, with sensitivity, specificity, positive predictive and negative predictive values. Results In patients with LGGs a combined score of at least 1 was the best predictor for progression (odds ratio (OR) 3.91) with 8.4 months median anticipation of diagnosis compared to standard MRI. The individual advanced magnetic resonance technique did not show a diagnostic accuracy comparable to the combination of the two. Overall diagnostic accuracy area under the curve (AUC) was 0.881. In patients with HGGs the multiparametric score did not improve diagnostic accuracy significantly. Perfusion MRI was the best predictor of progression (OR 3.65), with 6.7 months median anticipation of diagnosis. Overall diagnostic accuracy AUC was 0.897. Then spectroscopy and perfusion MRI are able to identify tumour progression during follow-up earlier than standard MRI. Conclusion In patients with LGGs the combination of the functional parameters seems to be the best method for diagnosis of progression. In patients with HGGs perfusion is the best diagnostic method.
Published: 2017

49. Long-term results after proactive management for locoregional control in patients with colonic cancer at high risk of peritoneal metastases

Author: J. Maherfouad Atta, Bianca Maria Sollazzo, Paolo Sammartino, Simone Sibio, Daniele Biacchi, A. Di Giorgio, Maurizio Cardi, Tommaso Cornali, Pietro Mingazzini, and Maria Sofia Rosati
Subjects: Male, medicine.medical_specialty, Organoplatinum Compounds, Colorectal cancer, Antineoplastic Agents, Disease-Free Survival, Peritoneal Neoplasm, advanced colorectal cancer, Humans, Medicine, Prospective Studies, Prospective cohort study, Peritoneal Neoplasms, Survival analysis, Aged, Retrospective Studies, prevention of peritoneal carcinomatosis, proactive management, peritoneal spread, business.industry, Gastroenterology, Case-control study, Retrospective cohort study, Hyperthermia, Induced, Middle Aged, medicine.disease, Survival Analysis, Surgery, Oxaliplatin, Chemotherapy, Adjuvant, Case-Control Studies, Colonic Neoplasms, Female, Hyperthermic intraperitoneal chemotherapy, Neoplasm Recurrence, Local, business, Follow-Up Studies, medicine.drug
Abstract: A major problem in treating patients with peritoneal spread from colorectal cancer is that at diagnosis wide peritoneal involvement often precludes all curative attempts. A possible solution is to identify those patients at risk for peritoneal metastases and intervene early to prevent locoregional disease spread before it develops and, thus, to improve outcome. We analyzed long-term results from a previous study and compared outcomes in 25 patients with advanced colon cancer considered at high risk for peritoneal spread (pT3/pT4 and mucinous or signet ring cell histology) prospectively included and managed with a proactive surgical approach including target organ resection for peritoneal spread plus hyperthermic intraperitoneal chemotherapy (HIPEC) and in 50 retrospectively well-matched controls who underwent standard surgical resection during the same period and in the same hospital by different surgical teams. At 48 months after the study closed, peritoneal metastases and local recurrence developed significantly less often in proactively managed patients than in controls (4 vs 28 %) (p
Published: 2014

50. Assessment of dose exposure and image quality in coronary angiography performed by 640-slice CT: a comparison between adaptive iterative and filtered back-projection algorithm by propensity analysis

Author: Alessandra Splendiani, Carlo Masciocchi, Antonio Gennarelli, Antonio Barile, Valentina Felli, Alessandra Di Sibio, Giovanni Luca Gravina, and Ernesto Di Cesare
Subjects: Male, Coronary angiography, Image quality, Coronary Angiography, Radiation Dosage, Image noise, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Prospective Studies, Propensity Score, Aged, Automatic exposure control, Neuroradiology, Radon transform, business.industry, General Medicine, Middle Aged, Propensity score matching, Radiographic Image Interpretation, Computer-Assisted, Female, Tomography, Tomography, X-Ray Computed, business, Nuclear medicine, Algorithm, Algorithms
Abstract: This study was performed to confirm, by propensity score matching, whether the use of adaptive-iterative dose reduction (AIDR 3D) with a built-in automatic exposure control system provides clinical and dosimetric advantages with respect to the traditional filtered back-projection (FBP) algorithm without automatic exposure modulation.A total of 200 consecutive patients undergoing coronary computed tomography (CT) angiography on a 640-slice CT scanner were studied. A protocol with exposure parameters based on patient body mass index (BMI) and with images reconstructed using FBP (group A) was compared with a protocol with images acquired using tube current decided by an automatic exposure control system and reconstructed using AIDR (group B). Mean effective dose and image quality with both objective and subjective measurements were assessed.Mean effective dose was 23.6 % lower in group B than in group A (2.56 versus 3.34 mSv; p0.0001). Noise was significantly lower in group B with consequent higher signal-to-noise (SNR) and contrast-to-noise (CNR) (p0.0001) compared with group A. Subjective quality parameters were also significantly higher in group B.Comparative analysis by propensity score matching confirms that AIDR 3D with automatic exposure control is able to reduce significantly the mean radiation dose and improve the image quality compared with traditional FBP without exposure modulation.
Published: 2014

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

110 results on '"Sibio, A"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources