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84 results on '"Sgura, A."'

1. How direct measurements of worker eyes with a Scheimpflug camera can affect lensdose coefficients in interventional radiology

Author: Marco Bertolini, Antonella Sgura, Alessandra Palma, G. Cucchi, Vando Piccagli, Claudia Giliberti, Lidia Strigari, Daniela D'Alessio, Maria Grazia Romano, Sveva Grande, Mauro Iori, Marco Sumini, Antonella Rosi, Antonio Moramarco, Vicente Bruzzaniti, Luigi Fontana, Lorenzo Piergallini, Federica Fioroni, Agnese Chendi, Lorenzo Isolan, Ion Udroiu, Lorenzo Lasagni, Iori M., Isolan L., Piergallini L., Chendi A., Lasagni L., Cucchi G., Bertolini M., Fioroni F., Piccagli V., Moramarco A., Romano M.G., Fontana L., Strigari L., D'Alessio D., Bruzzaniti V., Sgura A., Udroiu I., Rosi A., Grande S., Palma A., Giliberti C., Sumini M., Iori, M., Isolan, L., Piergallini, L., Chendi, A., Lasagni, L., Cucchi, G., Bertolini, M., Fioroni, F., Piccagli, V., Moramarco, A., Romano, M. G., Fontana, L., Strigari, L., D'Alessio, D., Bruzzaniti, V., Sgura, A., Udroiu, I., Rosi, A., Grande, S., Palma, A., Giliberti, C., and Sumini, M.
Subjects: genetic structures, Scheimpflug principle, Scheimpflug chamber, Emmetropia, len, Radiology, Interventional, Radiation Dosage, law.invention, Optics, eye model, law, Occupational Exposure, interventional radiology, Lens, Crystalline, Humans, Dosimetry, Radiation Dosimeter, Monte Carlo, Waste Management and Disposal, Physics, Dosimeter, Radiation Dosimeters, business.industry, Public Health, Environmental and Occupational Health, Radiant energy, General Medicine, eye diseases, Lens (optics), Absorbed dose, Radiation protection, business, radiation protection, Monte Carlo Method, Human
Abstract: The Directive 2013/59/Euratom established a reduction of the occupational exposure limits to the lens. Since it is become crucial to estimate the lens absorbed dose, the individual variability of exposed worker's ocular conformations with respect to the data estimated with their personal dosimetry has been studied. The anterior eye conformation of 45 exposed workers was acquired with Scheimpflug imaging and classified according to eye vision conditions (emmetropia, myopia or hypermetropia). Three eye models were computed, with two lens reconstructions, and implemented in an interventional radiology scenario by using Monte Carlo (MC) code. The models were dosimetrically analysed simulating setup A, a theoretical monoenergetic and isotropic photon's source (10-150 keV) and setup B, a more realistic interventional conditions with an angiographic X-ray unit (50, 75, 100 kV-peak). Scheimpflug imaging provided an average anterior chamber depth of (6.4 ± 0.5) mm and a lens depth of (3.9 ± 0.3) mm, together with a reconstructed equatorial lens length of (7.1 - 10.1) mm. Using this data for model's reconstruction, the dose conversion coefficients (DCs) for all ocular structures were simulated. Regardless of the eye model used, DCs show a similar trend with radiation energy which highlights, for the same energy and setup used, no significant dependence on ocular morphology and worker's visual conditions. The maximum difference obtained does not exceed 1% for all eye models or structures analysed. Therefore, the individual variabilities of worker ocular anatomy do not require any additional correction compared to the personal dosimetry data measured with a dedicated lens dosimeter. To estimate the absorbed dose to the other eye structures, it is essential instead to know the spectrum of the source that has generated the irradiation since there are differences considering monoenergetic sources or more realistic angiographic units.
Published: 2021
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2. Safety and efficacy of coronary sinus narrowing in chronic refractory angina: Insights from the RESOURCE study

Author: Arif A Khokhar, Carlo Zivelonghi, Mirthe Dekker, Geert E. Leenders, Roberto Ferrari, F Sgura, Stefan Verheye, Giuseppe Tarantini, Alessandro Cafaro, Jan-Peter van Kuijk, Stefano Guarracini, Christoph Liebetrau, Maayan Konigstein, Sergio Berti, Dan Ioanes, Matjaž Bunc, Pieter R. Stella, Leo Timmers, Issameddine Ajmi, Antonio Colombo, Shmuel Banai, Ranil de Silva, Francesco Ponticelli, Pierfrancesco Agostoni, Claudio Rapezzi, Max J. M. Silvis, Alfonso Ielasi, Matteo Tebaldi, M. Ciardetti, Jan Sebastian Wolter, Michele Di Mauro, Kevin Cheng, Gianluca Campo, Simon Redwood, Guglielmo Gallone, Francesco Giannini, Tiffany Patterson, Federico De Marco, Gianpiero D'Amico, Steffen Schnupp, and Steven Lindsay
Subjects: Canada, medicine.medical_specialty, medicine.medical_treatment, Chronic coronary syndrome, RESOURCE study, 030204 cardiovascular system & hematology, Refractory angina, NO, Percutaneous coronary intervention, Coronary artery disease, Angina, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Myocardial infarction, Israel, Coronary sinus reducer, Stroke, Coronary sinus, Retrospective Studies, business.industry, Coronary Sinus, Canadian Cardiovascular Society, medicine.disease, United Kingdom, Europe, Treatment Outcome, Cardiology, Cardiology and Cardiovascular Medicine, business, Mace
Abstract: Introduction Refractory angina (RA) is considered the end-stage of coronary artery disease, and often has no interventional treatment options. Coronary sinus Reducer (CSR) is a recent addition to the therapeutic arsenal, but its efficacy has only been evaluated on small populations. The RESOURCE registry provides further insights into this therapy. Methods The RESOURCE is an observational, retrospective registry that includes 658 patients with RA from 20 centers in Europe, United Kingdom and Israel. Prespecified endpoints were the amelioration of anginal symptoms evaluated with the Canadian Cardiovascular Society (CCS) score, the rates of procedural success and complications, and MACEs as composite of all-cause mortality, acute coronary syndromes, and stroke. Results At a median follow-up of 502 days (IQR 225–1091) after CSR implantation, 39.7% of patients improved by ≥2 CCS classes (primary endpoint), and 76% by ≥1 class. Procedural success was achieved in 96.7% of attempts, with 3% of procedures aborted mostly for unsuitable coronary sinus anatomy. Any complication occurred in 5.7% of procedures, but never required bailout surgery nor resulted in intra- or periprocedural death or myocardial infarction. One patient developed periprocedural stroke after inadvertent carotid artery puncture. At the last available follow-up, overall mortality and MACE were 10.4% and 14.6% respectively. At one, three and five years, mortality rate at Kaplan-Meier analysis was 4%, 13.7%, and 23.4% respectively. Conclusions CSR implantation is safe and reduces angina in patients with refractory angina.
Published: 2021
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3. Architecture and performance of the KM3NeT front-end firmware

Author: Suzan Basegmez du Pree, Daan van Eijk, Silvia Celli, Francisco Salesa Greus, Fabrizio Raffaelli, Joao Coelho, E. Tenllado, M. Taiuti, Carlos Maximiliano Mollo, S. Mazzou, Gisela Anton, Diego Real, S. Biagi, Antonio D'Onofrio, Giulia Illuminati, Alessandro Lonardo, E. Tzamariudaki, Alfonso Andres Garcia Soto, Uli Katz, Thijs van Eeden, David Muñoz Pérez, M. Morganti, Jörn Wilms, Thierry Pradier, S. Rivoire, P. Coyle, Imad El Bojaddaini, Zineb Aly, Giacomo Cuttone, M. Perrin-Terrin, Carlo Alessandro Nicolau, H. Brânzaş, Thomas Eberl, Dídac Diego-Tortosa, M. Bouta, K. Pikounis, Paolo Fermani, Gwenhaël de Wasseige, Mario Musumeci, D. Stavropoulos, Vincent van Beveren, S. Colonges, Veronique Van Elewyck, Abdelilah Moussa, Paolo Musico, Tommaso Chiarusi, Miles Lindsey Clark, P.M. Kooijman, R. Muller, S. M. Stellacci, Emanuele Leonora, S. R. Gozzini, M. Ardid, Jose Busto, Bouke Jisse Jung, Michael Kreter, M. Anghinolfi, A. Martini, N. Geißelbrecht, Annarita Margiotta, A. D'Amico, Dario Grasso, T. Thakore, Sara Pulvirenti, Jean Lesrel, Stefano Mastroianni, A. W. Chen, Doriane Drouhin, H. Hamdaoui, Mohamed Chabab, Jutta Schnabel, Giovanna Ferrara, J.J. Hernández-Rey, Jürgen Brunner, Rémy Le Breton, Raffaele Buompane, Damien Dornic, Angelo Orlando, Jos Steijger, Rosanna Cocimano, Irene Sgura, Antonio F. Díaz, Andrea Biagioni, S. Reck, Corinne Donzaud, Barbara Caiffi, Piotr Mijakowski, G. Pellegrini, Michel André, Alin Ilioni, Francesco Simeone, Fabio Marzaioli, Giancarlo Barbarino, M. Richer, Paolo Piattelli, A. Sinopoulou, M. Bendahman, C. Bagatelas, Sandra Zavatarelli, Juan Paris P. Gonzalez, R. Wojaczyński, R. Bruijn, Arnauld Albert, Riccardo Papaleo, Julien Aublin, M. Dörr, G. Androulakis, R. Coniglione, T. Gal, R. Gracia, C. Distefano, Antoine Kouchner, Ofelia Pisanti, Richard Dallier, Daniele Vivolo, D. F. E. Samtleben, A. Hekalo, Mancia Anguita, Matthias Bissinger, A. Zegarelli, Robert Lahmann, J. Hofestädt, Paolo Castaldi, Lilian Martin, Bernardino Spisso, C. Guidi, Pasquale Migliozzi, Jihad Boumaaza, Mitchell O'Sullivan, L. Maderer, R. Donà, Y. Gatelet, Natalia Zywucka, O. Rabyang, Agustin Sanchez Losa, Els Koffeman, Federico Versari, A. Belias, Bruny Baret, Markus Boettcher, Rezo Shanidze, Silvio Cherubini, J. Schumann, Francesco Leone, D. Guderian, D. Tzanetatos, Giorgi Kistauri, Cristiano Bozza, Kay Graf, Karel Melis, Walid Idrissi Ibnsalih, Soebur Razzaque, Piera Sapienza, V. Chiarella, J. Schmelling, G. Pühlhofer, Fabio Longhitano, V. Carretero, Nhan Chau, Piotr Kalaczyński, Giuseppina Larosa, Mauro De Palma, G. Papalashvili, Karl Mannheim, D. Zaborov, Marco Circella, Ahmed Eddyamoui, L. Nauta, Victor Espinosa Rosell, Matteo Sanguineti, Christos Markou, Carmelo Pellegrino, F. Garufi, C. Pieterse, V. Bertin, C. W. James, Alice Paun, M. D. Filipovic, G.E. Păvălaş, C. Poirè, G. Vasileiadis, Daniele Zito, S. Viola, Ankur Sharma, Ornella Leonardi, Maarten De Jong, Marta Colomer Molla, E. Berbee, Sergio Alves Garre, Emilio Migneco, Imanol Corredoira, Ad van den Berg, Nafis Rezwan Khan Chowdhury, Oleg Kalekin, M. Organokov, B. Ó Fearraigh, A. Creusot, Antonio Marinelli, Gennaro Miele, Giorgio Riccobene, Lucio Gialanella, J.D. Zornoza, Nunzio Randazzo, Giuseppe Levi, F. Filippini, Frits van der Knaap, Steven Tingay, Domenico Santonocito, J. Seneca, Michael Moser, Alba Domi, D. Calvo, Massimiliano Lincetto, D. Lopez-Coto, V. Popa, Steffen Hallmann, Hans van Haren, Irene Di Palma, Andrea Santangelo, Yahya Tayalati, Matthias Kadler, Paul de Jong, Peter Jansweijer, C. Pastore, Luis Salvador Miranda Palacios, J. Zúñiga, J.A. Martínez-Mora, Alexis Coleiro, Fabrizio Ameli, Alberto Rovelli, Emidio Giorgio, Vladimir Kulikovskiy, Luigi Antonio Fusco, Antonio Capone, J. Manczak, D. Elsaesser, Maurizio Spurio, E. Buis, F. Huang, A.J. Heijboer, M.C. Bouwhuis, Giuseppe Grella, Sebastiano Aiello, Thomas Lipreau, Els de Wolf, S. Sánchez Navas, Alexander Enzenhoefer, O. Gabella, KM3NeT (IHEF, IoP, FNWI), Aiello, Sebastiano, Albert, Arnauld, Garre, Sergio Alve, Aly, Zineb, Ameli, Fabrizio, Andre, Michel, Androulakis, Giorgo, Anghinolfi, Marco, Anguita, Mancia, Anton, Gisela, Ardid, Miquel, Aublin, Julien, Bagatelas, Christo, Barbarino, Giancarlo, Baret, Bruny, Basegmez du Pree, Suzan, Belias, Anastasio, Bendahman, Meriem, Berbee, Edward, van den Berg, Ad M., Bertin, Vincent, van Beveren, Vincent, Biagi, Simone, Biagioni, Andrea, Bissinger, Matthia, Boettcher, Marku, Boumaaza, Jihad, Bouta, Mohammed, Bouwhuis, Mieke, Bozza, Cristiano, Brânzaş, Horea, Bruijn, Ronald, Brunner, Jurgen, Buis, Ernst-Jan, Buompane, Raffaele, Busto, Jose, Caiffi, Barbara, Calvo, David, Capone, Antonio, Carretero, Victor, Castaldi, Paolo, Celli, Silvia, Chabab, Mohamed, Chau, Nhan, Chen, Andrew W., Cherubini, Silvio, Chiarella, Vitaliano, Chiarusi, Tommaso, Circella, Marco, Cocimano, Rosanna, Coelho, Joao A. B., Coleiro, Alexi, Molla, Marta C., Colonges, Stephane, Coniglione, Rosa, Corredoira, Imanol, Coyle, Paschal, Creusot, Alexandre, Cuttone, Giacomo, Amico, Antonio D’, D’Onofrio, Antonio, Dallier, Richard, De Palma, Mauro, Di Palma, Irene, Díaz, Antonio F., Diego-Tortosa, Didac, Distefano, Carla, Domi, Alba, Donà, Roberto, Donzaud, Corinne, Dornic, Damien, Dörr, Manuel, Drouhin, Doriane, Eberl, Thoma, Eddyamoui, Ahmed, van Eeden, Thij, van Eijk, Daan, El Bojaddaini, Imad, Elsaesser, Dominik, Enzenhoefer, Alexander, Rosell, Victor Espinosa, Fermani, Paolo, Ferrara, Giovanna, Filipović, Miroslav D., Filippini, Francesco, Fusco, Luigi A., Gabella, Omar, Gal, Tama, Soto, Alfonso Andres Garcia, Garufi, Fabio, Gatelet, Yoann, Geißelbrecht, Nicole, Gialanella, Lucio, Giorgio, Emidio, Gozzini, Sara R., Gracia, Rodrigo, Graf, Kay, Grasso, Dario, Grella, Giuseppe, Guderian, Daniel, Guidi, Carlo, Hallmann, Steffen, Hamdaoui, Hassane, van Haren, Han, Heijboer, Aart, Hekalo, Amar, Hernández-Rey, Juan J., Hofestädt, Jannik, Huang, Feifei, Ibnsalih, Walid Idrissi, Ilioni, Alin, Illuminati, Giulia, James, Clancy W., Jansweijer, Peter, de Jong, Maartin, de Jong, Paul, Jung, Bouke Jisse, Kadler, Matthia, Kalaczyński, Piotr, Kalekin, Oleg, Katz, Uli F., Khan Chowdhury, Nafis R., Kistauri, Giorgi, van der Knaap, Frit, Koffeman, Els N., Kooijman, Paul, Kouchner, Antoine, Kreter, Michael, Kulikovskiy, Vladimir, Lahmann, Robert, Larosa, Giuseppina, Le Breton, Remy, Leonardi, Ornella, Leone, Francesco, Leonora, Emanuele, Lesrel, Jean, Levi, Giuseppe, Lincetto, Massimiliano, Lindsey Clark, Mile, Lipreau, Thoma, Lonardo, Alessandro, Longhitano, Fabio, Lopez-Coto, Daniel, Maderer, Luka, Mańczak, Jerzy M., Mannheim, Karl, Margiotta, Annarita, Marinelli, Antonio, Markou, Christo, Martin, Lilian, Martínez-Mora, Juan A., Martini, Agnese, Marzaioli, Fabio, Mastroianni, Stefano, Mazzou, Safaa, Melis, Karel W., Miele, Gennaro, Migliozzi, Pasquale, Migneco, Emilio, Mijakowski, Piotr, Miranda Palacios, Luis S., Mollo, Carlos M., Morganti, Mauro, Moser, Michael, Moussa, Abdelilah, Muller, Rasa, Pérez, David Muñoz, Musico, Paolo, Musumeci, Mario, Nauta, Lodewijk, Navas, Sergio, Nicolau, Carlo A., Fearraigh, Brian Ó., O’Sullivan, Mitchell, Organokov, Mukharbek, Orlando, Angelo, González, Juan Palacio, Papalashvili, Gogita, Papaleo, Riccardo, Pastore, Cosimo, Păun, Alice M., Păvălaş, Gabriela E., Pellegrini, Giuliano, Pellegrino, Carmelo, Perrin-Terrin, Mathieu, Piattelli, Paolo, Pieterse, Camiel, Pikounis, Konstantino, Pisanti, Ofelia, Poirè, Chiara, Popa, Vlad, Pradier, Thierry, Pühlhofer, Gerd, Pulvirenti, Sara, Rabyang, Omphile, Raffaelli, Fabrizio, Randazzo, Nunzio, Razzaque, Soebur, Real, Diego, Reck, Stefan, Riccobene, Giorgio, Richer, Marc, Rivoire, Stephane, Rovelli, Alberto, Salesa Greus, Francisco, Samtleben, Dorothea F. E., Sánchez Losa, Agustin, Sanguineti, Matteo, Santangelo, Andrea E., Santonocito, Domenico, Sapienza, Piera, Schmelling, Jan-Willem, Schnabel, Jutta, Schumann, Johanne, Seneca, Jordan, Sgura, Irene, Shanidze, Rezo, Sharma, Ankur, Simeone, Francesco, Sinopoulou, Anna, Spisso, Bernardino, Spurio, Maurizio, Stavropoulos, Dimitri, Steijger, Jo, Stellacci, Simona Maria, Taiuti, Mauro, Tayalati, Yahya, Tenllado, Enrique, Thakore, Tarak, Tingay, Steven, Tzamariudaki, Ekaterini, Tzanetatos, Dimitrio, Van Elewyck, Veronique, Vasileiadis, George, Versari, Federico, Viola, Salvo, Vivolo, Daniele, de Wasseige, Gwenhael, Wilms, Joern, Wojaczyński, Rafa, de Wolf, El, Zaborov, Dmitry, Zavatarelli, Sandra, Zegarelli, Angela, Zito, Daniele, de Dios Zornoza, Juan, Zúñiga, Juan, Zywucka, Natalia, Aiello, S., Albert, A., Garre, S. A., Aly, Z., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., Du Pree, S. B., Belias, A., Bendahman, M., Berbee, E., Van Den Berg, A. M., Bertin, V., Van Beveren, V., Biagi, S., Biagioni, A., Bissinger, M., Boettcher, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Branzas, H., Bruijn, R., Brunner, J., Buis, E. -J., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. C., Colonges, S., Coniglione, R., Corredoira, I., Coyle, P., Creusot, A., Cuttone, G., Amico, A. D., D'Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Dona, R., Donzaud, C., Dornic, D., Doerr, M., Drouhin, D., Eberl, T., Eddyamoui, A., Van Eeden, T., Van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhoefer, A., Rosell, V. E., Fermani, P., Ferrara, G., Filipovic, M. D., Filippini, F., Fusco, L. A., Gabella, O., Gal, T., Soto, A. A. G., Garufi, F., Gatelet, Y., Geisselbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grella, G., Guderian, D., Guidi, C., Hallmann, S., Hamdaoui, H., Van Haren, H., Heijboer, A., Hekalo, A., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Ibnsalih, W. I., Ilioni, A., Illuminati, G., James, C. W., Jansweijer, P., De Jong, M., De Jong, P., Jung, B. J., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. K., Kistauri, G., Van Der Knaap, F., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Larosa, G., Le Breton, R., Leonardi, O., Leone, F., Leonora, E., Lesrel, J., Levi, G., Lincetto, M., Clark, M. L., Lipreau, T., Lonardo, A., Longhitano, F., Lopez-Coto, D., Maderer, L., Manczak, J. M., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Mazzou, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Palacios, L. S. M., Maximiliano Mollo, C., Morganti, M., Moser, M., Moussa, A., Muller, R., Perez, D. M., Musico, P., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Fearraigh, B. O., O'Sullivan, M., Organokov, M., Orlando, A., Gonzalez, J. P., Papalashvili, G., Papaleo, R., Pastore, C., Paun, A. M., Pavalas, G. E., Pellegrini, G., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poire, C., Popa, V., Pradier, T., Puhlhofer, G., Pulvirenti, S., Rabyang, O., Raffaelli, F., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Richer, M., Rivoire, S., Rovelli, A., Salesa Greus, F., Samtleben, D. F. E., Losa, A. S., Sanguineti, M., Santangelo, A. E., Santonocito, D., Sapienza, P., Schmelling, J. -W., Schnabel, J., Schumann, J., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., De Wasseige, G., Wilms, J., Wojaczynski, R., De Wolf, E., Zaborov, D., Zavatarelli, S., Zegarelli, A., Zito, D., De Dios Zornoza, J., Zuniga, J., Zywucka, N., Groupe de Recherche en Physique des Hautes Energies (GRPHE), Institut Universitaire de Technologie de Colmar-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), KM3NeT, Research unit Astroparticle Physics, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-IUT de Colmar, Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire d'Etude du Rayonnement et de la Matière en Astrophysique et Atmosphères = Laboratory for Studies of Radiation and Matter in Astrophysics and Atmospheres (LERMA), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), ANR-15-CE31-0020,DAEMONS,Démonstration de la possibilité d'établir l'ordonnancement des masses de neutrinos dans la mer(2015), ANR-10-LABX-0023,UnivEarthS,Earth - Planets - Universe: observation, modeling, transfer(2010), ANR-18-IDEX-0001,Université de Paris,Université de Paris(2018), Centre Tecnològic de Vilanova i la Geltrú, and Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques
Subjects: Astrofísica, acquisition firmware, KM3NeT, neutrino telescope, time to digital converters, Computer science, data acquisition, Physics::Instrumentation and Detectors, time-to-digital converter, computer.software_genre, Astrophysics, Neutrino telescope, 01 natural sciences, Front and back ends, Time-to-digital converter, Atmospheric Cherenkov telescopes, time to digital converter, 010303 astronomy & astrophysics, Instrumentation, FPGA, Clocks, photomultiplier, Firmware, 4. Education, Physics, Electrical engineering, Astrophysics::Instrumentation and Methods for Astrophysics, Electronic, Optical and Magnetic Materials, Acquisition firmware, Neutrino, performance, Photomultiplier, Logic, Astrophysics::High Energy Astrophysical Phenomena, Physique [physics]/Physique [physics], Partícules (Física nuclear), 010309 optics, 0103 physical sciences, Quantization, 14. Life underwater, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Field-programmable gate array, Cherenkov radiation, Particles (Nuclear physics), Detectors òptics, Time to digital converters, Optical detectors, Control systems, Photons, Física [Àrees temàtiques de la UPC], Telescopis, business.industry, Mechanical Engineering, Data acquisition, Field programmable gate arrays, Astronomy and Astrophysics, Physique [physics]/Physique des Hautes Energies - Expérience [hep-ex], Space and Planetary Science, Control and Systems Engineering, FISICA APLICADA, electronics: readout, business, computer, Telescopes, electronics: design
Abstract: The authors acknowledge the financial support of the funding agencies: Agence Nationale de la Recherche (contract ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), Paris Ile-de-France Region, France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG, FR-18-1268), Georgia; Deutsche Forschungsgemeinschaft (DFG), Germany; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), PRIN 2017 program (Grant NAT-NET 2017W4HA7S) Italy; Ministry of Higher Education Scientific Research and Professional Training, ICTP through Grant AF-13, Morocco; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; The National Science Centre, Poland (2015/18/E/ST2/00758); National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), Junta de Andalucia (ref. SOMM17/6104/UGR), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119) and GenT (ref. CIDEGENT/2018/034) programs, La Caixa Foundation (ref. LCF/BQ/IN17/11620019), EU: MSC program (ref. 713673), Spain., The KM3NeT infrastructure consists of two deep-sea neutrino telescopes being deployed in the Mediterranean Sea. The telescopes will detect extraterrestrial and atmospheric neutrinos by means of the incident photons induced by the passage of relativistic charged particles through the seawater as a consequence of a neutrino interaction. The telescopes are configured in a three-dimensional grid of digital optical modules, each hosting 31 photomultipliers. The photomultiplier signals produced by the incident Cherenkov photons are converted into digital information consisting of the integrated pulse duration and the time at which it surpasses a chosen threshold. The digitization is done by means of time to digital converters (TDCs) embedded in the field programmable gate array of the central logic board. Subsequently, a state machine formats the acquired data for its transmission to shore. We present the architecture and performance of the front-end firmware consisting of the TDCs and the state machine., French National Research Agency (ANR) ANR-15-CE31-0020, Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund), France, Commission Europeenne (Marie Curie Program), France, Institut Universitaire de France (IUF), France, LabEx UnivEarthS, France ANR-10-LABX-0023 ANR-18-IDEX-0001, Paris Ile-de-France Region, France, Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268, German Research Foundation (DFG), Greek Ministry of Development-GSRT, Istituto Nazionale di Fisica Nucleare (INFN) NAT-NET 2017W4HA7S, Ministry of Education, Universities and Research (MIUR) NAT-NET 2017W4HA7S, PRIN 2017 program Italy NAT-NET 2017W4HA7S, Ministry of Higher Education Scientific Research and Professional Training, ICTP, Morocco AF-13, Netherlands Organization for Scientific Research (NWO) Netherlands Government, National Science Centre, Poland 2015/18/E/ST2/00758, National Authority for Scientific Research (ANCS), Romania, Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (MCIU/FEDER), Spain PGC2018-096663-B-C41 PGC2018-096663-A-C42 PGC2018-096663-B-C43 PGC2018-096663-B-C44, Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), Spain, Junta de Andalucia European Commission SOMM17/6104/UGR, Generalitat Valenciana: Grisolia program, Spain GRISOLIA/2018/119, Generalitat Valenciana: GenT program, Spain CIDEGENT/2018/034, La Caixa Foundation LCF/BQ/IN17/11620019, EU: MSC program, Spain 713673
Published: 2021
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4. Percutaneous pericardiocentesis for pericardial effusion: predictors of mortality and outcomes

Author: F Sgura, Jacopo Francesco Imberti, Giuseppe Longo, Marco Vitolo, Giulia Nanni, Andrea Pennacchioni, Giuseppe Boriani, Rosario Rossi, Daniel Monopoli, and Salvatore Arrotti
Subjects: Male, medicine.medical_specialty, medicine.medical_treatment, Population, Pericardial effusion, 030204 cardiovascular system & hematology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, Cardiac tamponade, Internal Medicine, Humans, Medicine, Hospital Mortality, 030212 general & internal medicine, Mortality, education, Aged, Retrospective Studies, Neoplastic effusion, Pericardiocentesis, education.field_of_study, business.industry, Hazard ratio, Middle Aged, medicine.disease, Cardiac Tamponade, Im - Original, Treatment Outcome, Emergency Medicine, Cardiology, Female, Tamponade, business, Forecasting
Abstract: Pericardial effusion can dangerously precipitate patient’s hemodynamic stability and requires prompt intervention in case of tamponade. We investigated potential predictors of in-hospital mortality, a composite outcome of in-hospital mortality, pericardiocentesis-related complications, and the need for emergency cardiac surgery and all-cause mortality in patients undergoing percutaneous pericardiocentesis. This is an observational, retrospective, single-center study on patients undergoing percutaneous pericardiocentesis (2010–2019). We enrolled 81 consecutive patients. Median age was 71.4 years (interquartile range [IQR] 58.1–78.1 years) and 51 (63%) were male. Most of the pericardiocentesis were performed in an urgency setting (76.5%) for cardiac tamponade (77.8%). The most common etiology was idiopathic (33.3%) followed by neoplastic (22.2%). In-hospital mortality was 14.8% while mortality during follow-up (mean 17.1 months) was 44.4%. Only hemodynamic instability (i.e., cardiogenic shock, hypotension refractory to fluid challenge therapy and inotropes) was associated with in-hospital mortality at the univariate analysis (odds ratio [OR] 7.2; 95% confidence interval [CI] 1.76–29.4). Non-neoplastic/non-idiopathic etiology and hemodynamic instability were associated with the composite outcome of in-hospital mortality, need for emergency cardiac surgery, or pericardiocentesis-related complications (OR 5.75, 95% CI 1.65–20.01, and OR 5.81, 95% CI 2.11–15.97, respectively). Multivariate Cox regression analysis adjusted for possible confounding variables (age, coronary artery disease, and hemodynamic instability) showed that neoplastic etiology was independently associated with medium-term mortality (hazard ratio [HR] 4.05, 95% CI 1.45–11.36). In a real-world population treated with pericardiocentesis for pericardial effusion, in-hospital adverse outcomes and medium-term mortality are consistent, in particular for patients presenting with hemodynamic instability or neoplastic pericardial effusion.
Published: 2021
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5. Usefulness of Coronary Sinus Reducer Implantation for the Treatment of Chronic Refractory Angina Pectoris

Author: Salvatore Saccà, Gianpiero D'Amico, Marco Cerrito, Alessandro Cafaro, Sergio Ghiringhelli, Giuseppe Tarantini, Francesco Versaci, Matteo Tebaldi, F Sgura, Andrea Picchi, Roberto Latini, Francesco Giannini, Giulio G. Stefanini, Marco Ciardetti, Achille Gaspardone, Mauro Massussi, Federico De Marco, and Alfonso Ielasi
Subjects: Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, 030204 cardiovascular system & hematology, Coronary Angiography, Revascularization, Angina Pectoris, Prosthesis Implantation, Angina, 03 medical and health sciences, 0302 clinical medicine, Refractory, Quality of life, Internal medicine, medicine, Humans, 030212 general & internal medicine, Coronary sinus, Aged, Retrospective Studies, Reducer, business.industry, Coronary Sinus, Retrospective cohort study, medicine.disease, Treatment Outcome, Chronic Disease, Cohort, Cardiology, Female, Stents, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
Abstract: The coronary sinus (CS) Reducer is a novel device designed for the management of patients with severe angina symptoms refractory to optimal medical therapy and not amenable to further revascularization. Aim of this study was to investigate the efficacy and the safety of the CS Reducer device in a real-world, multicenter, and country-level cohort of patients presenting with refractory angina pectoris. The study included patients affected by refractory angina pectoris who underwent CS Reducer implantation in 16 centers. Clinical follow-up was carried as per each center's protocol. One hundred eighty-seven patients were included. Technical and procedural success were achieved in 98% and 95%, respectively. Minor peri-procedural complications were recorded in 8 patients. During a median follow-up of 18.4 months, 135 (82.8%) patients demonstrated at least 1 CCS class reduction after Reducer implantation, and 80 (49%) patients at least 2 CCS class reduction. Mean CCS class improved from 3.05 ± 0.53 at baseline to 1.63 ± 0.98 at follow-up (p < 0.001). Treatment benefit was also reflected in a significant improvement in quality of life scores and in a reduction of the mean number of anti-ischemic drugs prescribed for patient. In conclusion, in this multicenter, country-level study, the implantation of CS Reducer in patients with refractory angina pectoris resulted to be safe and effective in reducing of angina pectoris and improving quality of life.
Published: 2021
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6. Effect on mortality of different routes of administration and loading dose of aspirin in patients with ST-segment elevation acute myocardial infarction treated with primary angioplasty

Author: Cristina Rolando, Fabio Alfredo Sgura, Rosario Rossi, Marisa Talarico, Daniel Monopoli, Giuseppe Boriani, Alessandra Bagnacani, and Francesca Coppi
Subjects: Male, Time Factors, Platelet Aggregation, Primary angioplasty, 030204 cardiovascular system & hematology, Coronary Angiography, Loading dose, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, ST segment, In patient, Hospital Mortality, 030212 general & internal medicine, Myocardial infarction, Angioplasty, Balloon, Coronary, Aged, Retrospective Studies, Aspirin, Dose-Response Relationship, Drug, business.industry, Drug Administration Routes, Mortality rate, Retrospective cohort study, General Medicine, medicine.disease, Survival Rate, Treatment Outcome, Italy, Anesthesia, ST Elevation Myocardial Infarction, Female, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, Follow-Up Studies, medicine.drug
Abstract: BACKGROUND Aspirin is the cornerstone of the anti-platelet therapy during the acute phase of ST-segment elevation myocardial infarction (STEMI), and it can be administrated orally or intravenously. The oral loading dose of aspirin is well characterized, whereas there are little data on the optimal intravenous (IV) loading dose. AIM To confirm if the mortality of patients treated with a loading dose of IV aspirin was comparable to that of patients treated with the most usual aspirin per os. PATIENTS AND METHODS We analyzed the overall mortality during hospitalization and at 1 year follow-up among 756 consecutive patients with STEMI. Four hundred seventy-eight (63.2%) patients received per os and 278 (36.8%) IV aspirin. We divided the 278 patients of the IV aspirin group into two subgroups, based on the median value of the dose of aspirin used as a load. RESULTS The per os aspirin group took 234 ± 138 mg of aspirin per os at the first medical contact; the IV low-dose group 194 ± 87 mg, and the IV high-dose group 483 ± 194 mg of IV aspirin. No differences were observed in mortality rate after 1-year of follow-up. In-hospital mortality resulted significantly higher (9.3%) in the IV high-dose group respect to the IV low-dose one (5.0%) and per os aspirin group (6.0%) (P < 0.01 for both). CONCLUSION In this retrospective study, high dose IV aspirin loading in STEMI increased intra-hospital mortality. Further study is necessary to define the optimal dose of intravenous aspirin in STEMI.
Published: 2020
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7. The Control Unit of the KM3NeT Data Acquisition System

Author: A. Franco, J. Reubelt, A. Enzenhöfer, M. Taiuti, Carlos Maximiliano Mollo, A. Sinopoulou, Robert Lahmann, D. Zaborov, R. Donà, Antonio D'Onofrio, Thierry Pradier, G. Pühlhofer, G. Polydefki, Soebur Razzaque, Jörn Wilms, I. Salvadori, F. van der Knaap, S. Mazzou, F. Garufi, L. Nauta, H. Hamdaoui, V. Sciacca, M. Post, C. Markou, Gisela Anton, G. Martignac, R. Wojaczyński, G. Ferrara, M. Circella, Emanuele Leonora, E. Tzamariudaki, Nhan Chau, Vitaliano Chiarella, Riccardo Papaleo, Mohamed Chabab, Andrea Biagioni, R. Gracia, L. Quinn, M. Organokov, B. Ó Fearraigh, Matteo Sanguineti, E. Berbee, A. Rapicavoli, K. Pikounis, N. R. Khan Chowdhury, G. Androulakis, J.J. Hernández-Rey, Dominik Elsaesser, Yahya Tayalati, Francesco Leone, M. de Jong, Simona Maria Stellacci, A. Marinelli, C. Nielsen, M. De Palma, O. Kalekin, Jose Busto, G. Riccobene, Ofelia Pisanti, A. Sánchez Losa, M. Perrin-Terrin, F. Huang, Luigi Antonio Fusco, H. Brânzaş, Paolo Fermani, Rosanna Cocimano, Daniele Vivolo, I. Sgura, T. Thakore, Els Koffeman, M.C. Bouwhuis, Carlo Alessandro Nicolau, D. Tzanetatos, M. Lindsey Clark, Piotr Kalaczyński, Mario Musumeci, U. Katz, N. Randazzo, R. Mele, F. Versari, Angelo Orlando, Cristiano Bozza, M. Ardid, M. Morganti, Joao A B Coelho, P. Jansweijer, L. Martin, Silvia Celli, T. Grégoire, P. Migliozzi, Maurizio Spurio, A. Creusot, A.J. Heijboer, P. Coyle, Bruny Baret, G. Maggi, Dídac Diego-Tortosa, M. Anghinolfi, T. Gal, C. Distefano, D. F. E. Samtleben, A. Hekalo, Sara Pulvirenti, C. Pastore, V. van Beveren, Giacomo Cuttone, Alessandro Lonardo, Giuseppina Larosa, S.F. Biagi, E. A. De Wolf, Damien Dornic, Jos Steijger, M. Bouta, G. Papalashvili, Paolo Sapienza, Corinne Donzaud, Thomas Eberl, S. Viola, G. C. Barbarino, M. Durocher, E. Migneco, G. de Wasseige, M. Bissinger, Hassnae Eljarrari, A. Sharma, Karl Mannheim, Silvio Cherubini, B. Spisso, M. Richer, V. Panagopoulos, M. Bendahman, C. Bagatelas, Lucio Gialanella, J.D. Zornoza, Alessia Capone, P.M. Kooijman, J. Aublin, Matthias Kadler, Steven Tingay, J. Zúñiga, Rezo Shanidze, J. Seneca, Tommaso Chiarusi, Annarita Margiotta, G.E. Păvălaş, R. Bruijn, A. Garcia Soto, Domenico Santonocito, J.A. Martínez-Mora, Alexis Coleiro, Richard Dallier, R. Le Breton, Michael Moser, Dario Grasso, Fabrizio Ameli, S. Colonges, V. Bertin, R. Muller, Louis-Marie Rigalleau, Massimiliano Lincetto, R. Coniglione, Emidio Giorgio, Alba Domi, D. Calvo, S. R. Gozzini, J. Hofestädt, D. Lopez-Coto, Jihad Boumaaza, M. Bruchner, V. Popa, Fabio Marzaioli, Gilles Bouvet, Steffen Hallmann, H. van Haren, I. El Bojaddaini, L. S. Miranda, F. Raffaelli, S. Basegmez du Pree, Miroslav Filipovic, Andrea Santangelo, Michel André, S. Bourret, C. Poirè, P. Piattelli, A.M. van den Berg, V. Van Elewyck, P. Mijakowski, B. Strandberg, C. Pieterse, C. W. James, E. Tenllado, Giulia Illuminati, Jutta Schnabel, D. Stransky, S. Reck, G. Vannoye, D. Guderian, Kay Graf, Karel Melis, J. Brunner, Fabio Longhitano, A. Martini, Antoine Kouchner, A. Zegarelli, M. Colomer Molla, Raffaele Buompane, I. Di Palma, Antonio F. Díaz, Francesco Simeone, Vladimir Kulikovskiy, J. Manczak, C. Guidi, E. Buis, Sebastiano Aiello, G. Grella, S. Sánchez Navas, M. Dörr, C. Pellegrino, Giuseppe Levi, P. de Jong, D. Stavropoulos, A. Rovelli, Abdelilah Moussa, Diego Real, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), KM3NeT, Aiello, S., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Bagatelas, C., Barbarino, G., Baret, B., du Pree, S. B., Bendahman, M., Berbee, E., van den Berg, A. M., Bertin, V., van Beveren, V., Biagi, S., Biagioni, A., Bissinger, M., Boumaaza, J., Bourret, S., Bouta, M., Bouvet, G., Bouwhuis, M., Bozza, C., Branzas, H., Bruchner, M., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Celli, S., Chabab, M., Chau, N., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. C., Colonges, S., Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D'Onofrio, A., Dallier, R., De Palma, M., Di Palma, I., Diaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Dona, R., Donzaud, C., Dornic, D., Dorr, M., Durocher, M., Eberl, T., El Bojaddaini, I., Eljarrari, H., Elsaesser, D., Enzenhofer, A., Fermani, P., Ferrara, G., Filipovic, M. D., Franco, A., Fusco, L. A., Gal, T., Soto, A. G., Garufi, F., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Gregoire, T., Grella, G., Guderian, D., Guidi, C., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hernandez-Rey, J. J., Hofestadt, J., Huang, F., Illuminati, G., James, C. W., Jansweijer, P., de Jong, M., de Jong, P., Kadler, M., Kalaczynski, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. K., van der Knaap, F., Koffeman, E. N., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Larosa, G., Le Breton, R., Leone, F., Leonora, E., Levi, G., Lincetto, M., Clark, M. L., Lonardo, A., Longhitano, F., Lopez-Coto, D., Maggi, G., Manczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martignac, G., Martin, L., Martinez-Mora, J. A., Martini, A., Marzaioli, F., Mazzou, S., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., O Fearraigh, B., Organokov, M., Orlando, A., Panagopoulos, V., Papalashvili, G., Papaleo, R., Pastore, C., Pavalas, G. E., Pellegrino, C., Perrin-Terrin, M., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poire, C., Polydefki, G., Popa, V., Post, M., Pradier, T., Puhlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Rapicavoli, A., Razzaque, S., Real, D., Reck, S., Reubelt, J., Riccobene, G., Richer, M., Rigalleau, L., Rovelli, A., Salvadori, I., Samtleben, D. F. E., Sanchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schnabel, J., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Taiuti, M., Tayalati, Y., Tenllado, E., Thakore, T., Tingay, S., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vannoye, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczynski, R., de Wolf, E., Zaborov, D., Zegarelli, A., Zornoza, J. D., Zuniga, J., Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, KM3NeT (IHEF, IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Université de Nantes - Faculté des Sciences et des Techniques, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Research unit Astroparticle Physics, Aiello S., Ameli F., Andre M., Androulakis G., Anghinolfi M., Anton G., Ardid M., Aublin J., Bagatelas C., Barbarino G., Baret B., du Pree S.B., Bendahman M., Berbee E., van den Berg A.M., Bertin V., van Beveren V., Biagi S., Biagioni A., Bissinger M., Boumaaza J., Bourret S., Bouta M., Bouvet G., Bouwhuis M., Bozza C., Branzas H., Bruchner M., Bruijn R., Brunner J., Buis E., Buompane R., Busto J., Calvo D., Capone A., Celli S., Chabab M., Chau N., Cherubini S., Chiarella V., Chiarusi T., Circella M., Cocimano R., Coelho J.A.B., Coleiro A., Molla M.C., Colonges S., Coniglione R., Coyle P., Creusot A., Cuttone G., D'Onofrio A., Dallier R., De Palma M., Di Palma I., Diaz A.F., Diego-Tortosa D., Distefano C., Domi A., Dona R., Donzaud C., Dornic D., Dorr M., Durocher M., Eberl T., El Bojaddaini I., Eljarrari H., Elsaesser D., Enzenhofer A., Fermani P., Ferrara G., Filipovic M.D., Franco A., Fusco L.A., Gal T., Soto A.G., Garufi F., Gialanella L., Giorgio E., Gozzini S.R., Gracia R., Graf K., Grasso D., Gregoire T., Grella G., Guderian D., Guidi C., Hallmann S., Hamdaoui H., van Haren H., Heijboer A., Hekalo A., Hernandez-Rey J.J., Hofestadt J., Huang F., Illuminati G., James C.W., Jansweijer P., de Jong M., de Jong P., Kadler M., Kalaczynski P., Kalekin O., Katz U.F., Chowdhury N.R.K., van der Knaap F., Koffeman E.N., Kooijman P., Kouchner A., Kulikovskiy V., Lahmann R., Larosa G., Le Breton R., Leone F., Leonora E., Levi G., Lincetto M., Clark M.L., Lonardo A., Longhitano F., Lopez-Coto D., Maggi G., Manczak J., Mannheim K., Margiotta A., Marinelli A., Markou C., Martignac G., Martin L., Martinez-Mora J.A., Martini A., Marzaioli F., Mazzou S., Mele R., Melis K.W., Migliozzi P., Migneco E., Mijakowski P., Miranda L.S., Mollo C.M., Morganti M., Moser M., Moussa A., Muller R., Musumeci M., Nauta L., Navas S., Nicolau C.A., Nielsen C., O Fearraigh B., Organokov M., Orlando A., Panagopoulos V., Papalashvili G., Papaleo R., Pastore C., Pavalas G.E., Pellegrino C., Perrin-Terrin M., Piattelli P., Pieterse C., Pikounis K., Pisanti O., Poire C., Polydefki G., Popa V., Post M., Pradier T., Puhlhofer G., Pulvirenti S., Quinn L., Raffaelli F., Randazzo N., Rapicavoli A., Razzaque S., Real D., Reck S., Reubelt J., Riccobene G., Richer M., Rigalleau L., Rovelli A., Salvadori I., Samtleben D.F.E., Sanchez Losa A., Sanguineti M., Santangelo A., Santonocito D., Sapienza P., Schnabel J., Sciacca V., Seneca J., Sgura I., Shanidze R., Sharma A., Simeone F., Sinopoulou A., Spisso B., Spurio M., Stavropoulos D., Steijger J., Stellacci S.M., Strandberg B., Stransky D., Taiuti M., Tayalati Y., Tenllado E., Thakore T., Tingay S., Tzamariudaki E., Tzanetatos D., Van Elewyck V., Vannoye G., Versari F., Viola S., Vivolo D., de Wasseige G., Wilms J., Wojaczynski R., de Wolf E., Zaborov D., Zegarelli A., Zornoza J.D., Zuniga J., Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique)
Subjects: Computer science, data acquisition, Distributed computing, Data management, Astroparticle detector, Control unit, General Physics and Astronomy, Oceanografia, Oceanography, 01 natural sciences, High Energy Physics - Experiment, 010305 fluids & plasmas, Neutrino detector, High Energy Physics - Experiment (hep-ex), Software, Data acquisition, KM3NeT, data acquisition control, neutrino detector, astroparticle detector, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Neutrino detectors, modular, KM3NeT Data acquisition control Neutrino detector Astroparticle detector, [PHYS]Physics [physics], 4. Education, Control reconfiguration, Astroparticle detecto, 29.85.Ca, Hardware and Architecture, control system, Astrophysics - Instrumentation and Methods for Astrophysics, FOS: Physical sciences, programming, Failover, 07.05.Hd, Data acquisition control, 0103 physical sciences, Neutrins, 14. Life underwater, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Física [Àrees temàtiques de la UPC], Telescopis, business.industry, Provisioning, FISICA APLICADA, data management, business, Software architecture, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Telescopes
Abstract: The KM3NeT Collaboration runs a multi-site neutrino observatory in the Mediterranean Sea. Water Cherenkov particle detectors, deep in the sea and far off the coasts of France and Italy, are already taking data while incremental construction progresses. Data Acquisition Control software is operating off-shore detectors as well as testing and qualification stations for their components. The software, named Control Unit, is highly modular. It can undergo upgrades and reconfiguration with the acquisition running. Interplay with the central database of the Collaboration is obtained in a way that allows for data taking even if Internet links fail. In order to simplify the management of computing resources in the long term, and to cope with possible hardware failures of one or more computers, the KM3NeT Control Unit software features a custom dynamic resource provisioning and failover technology, which is especially important for ensuring continuity in case of rare transient events in multi-messenger, French National Research Agency (ANR) ANR-15-CE31-0020, Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund), European Union (EU), Institut Universitaire de France (IUF), France, IdEx program, Univearths Labex program at Sorbonne Paris Cite, France ANR-10-LABX-0023 ANR-11-IDEX-000502, Paris Ile-de-France Region, France, Shota Rustaveli National Science Foundation of Georgia (SRNSFG), Georgia FR-18-1268, German Research Foundation (DFG), Greek Ministry of Development-GSRT, Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), PRIN 2017 program Italy NAT-NET 2017W4HA7S, Ministry of Higher Education, Scientific Research and Professional Training, Morocco, Netherlands Organization for Scientific Research (NWO) Netherlands Government, National Science Center, Poland National Science Centre, Poland 2015/18/E/ST2/00758, National Authority for Scientific Research (ANCS), Romania, Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU), Spain, Programa Estatal de Generacion de Conocimiento (MCIU/FEDER) PGC2018-096663-B-C41 PGC2018-096663-A-C42 PGC2018-096663-B-C43 PGC2018-096663-BC44, Severo Ochoa Centre of Excellence, MultiDark Consolider (MCIU), Spain, Junta de Andalucía, Generalitat Valenciana, Spain: Grisolia GRISOLIA/2018/119, Generalitat Valenciana CIDEGENT/2018/034, La Caixa Foundation LCF/BQ/IN17/11620019, EU: MSC program, Spain 713673
Published: 2020
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8. City Logistics in historic centers: Multi-Criteria Evaluation in GIS for city of Salvador (Bahia – Brazil)

Author: Juan Pedro Moreno Delgado and Marcella Sgura Viana
Subjects: 050210 logistics & transportation, Geographic information system, Land use, business.industry, 05 social sciences, Geography, Planning and Development, 0211 other engineering and technologies, Geoprocessing, 021107 urban & regional planning, Transportation, Land-use planning, 02 engineering and technology, Urban Studies, Geography, Traffic congestion, Urban planning, 0502 economics and business, Zoning, business, Environmental planning, Trip generation
Abstract: The City Logistic brings a new concept in land use planning and management of urban logistics flows, resolving problems related to urban goods movement, while seeking a balance between the efficiency required by urban freight and the social costs involved (traffic congestion product, environmental impacts and energy conservation). This article seeks to investigate the relationship between urban freight and shape, design, zoning and urban planning to establish City Logistic strategies that support land use planning and organization of logistics flows in the city center of Salvador, Bahia, Brazil. The methodology is mainly based on the use of geoprocessing techniques which are used do diagnose the spatial concentration of Freight Trip Generation Centers in terms of the potentially produced travel in Salvador’s central area. Furthermore, the methodology used the Multi-Criteria Evaluation (MCE) in GIS (Geographic Information System) for identifying suitability maps related to urban logistics activities and land use compatibility. The latter served as a basis to identify strategies and measures of City Logistic to support the improvement of urban logistics in the study area.
Published: 2019
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9. Red blood cell distribution width in patients undergoing transcatheter aortic valve implantation: Implications for outcomes

Author: Luciano Losi, Anna Chiara Valenti, Davide Gabbieri, Luigi Vignali, Marcella Manicardi, F Sgura, Giuseppe Boriani, Salvatore Arrotti, Paolo Magnavacchi, Marco Vitolo, Stefano Tondi, and Vincenzo Guiducci
Subjects: Erythrocyte Indices, Male, Aortic valve, medicine.medical_specialty, Erythrocytes, 030204 cardiovascular system & hematology, Transcatheter Aortic Valve Replacement, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, 80 and over, medicine, Clinical endpoint, Humans, 030212 general & internal medicine, Aged, 80 and over, Aortic Valve, Female, Retrospective Studies, Treatment Outcome, Aortic Valve Stenosis, Aged, Proportional hazards model, business.industry, Hazard ratio, Red blood cell distribution width, Retrospective cohort study, General Medicine, Odds ratio, medicine.disease, medicine.anatomical_structure, Aortic valve stenosis, Cardiology, business
Abstract: Background Red cell distribution width (RDW) is recently emerging as a prognostic indicator in many cardiovascular diseases. However, less is known about its predictive role in patients undergoing transcatheter aortic valve implantation (TAVI). Methods We retrospectively included very high-risk patients with severe aortic valve stenosis undergoing TAVI between February 2012 and December 2019. Patients were classified according to RDW tertiles. Our primary endpoint was long-term all-cause mortality. The secondary endpoint was a composite of in-hospital major adverse events as defined by the Valve Academic Research Consortium 2 criteria and/or long-term all-cause mortality. Results A total of 424 patients [median age 83.5 years, 52.6% females] were analysed. After a median follow-up of 1.55 years, all-cause mortality was 25.5%. At the multivariate-adjusted Cox regression analysis, patients in the highest RDW tertile were associated with a higher risk for all-cause mortality [hazard ratio [HR] 1.73, 95%confidence interval [CI] 1.02-2.95] compared with the lowest tertile. When considering RDW as a continuous variable, we found an 11% increased risk in overall mortality [HR 1.11, 95% CI 1.00-1.24] for each increased point in RDW. The highest RDW tertile was also independently associated with the occurrence of the composite endpoint [odds ratio [OR] 2.10, 95% CI 1.17-3.76] compared with lower tertiles. Conclusions In our cohort, elevated basal RDW values were independent predictors of increased long-term mortality and higher rate of in-hospital adverse events. The inclusion of a routinely available biomarker as RDW, may help the pre-operative risk assessment in potential TAVI candidates and optimise their management.
Published: 2021
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10. KM3NeT front-end and readout electronics system: hardware, firmware and software

Author: Sebastiano Aiello, Annarita Margiotta, Antonio Marinelli, Christos Markou, Gregory Martignac, Lilian Martin, Juan A. Martínez-Mora, Agnese Martini, Fabio Marzaioli, Safaa Mazzou, Rosa Mele, Karel W. Melis, Pasquale Migliozzi, Emilio Migneco, Piotr Mijakowski, Luis S. Miranda, Carlos M. Mollo, Mauro Morganti, Michael Moser, Abdelilah Moussa, Rasa Muller, Paolo Musico, Mario Musumeci, Lodewijk Nauta, Sergio Navas, Carlo A. Nicolau, Christine Nielsen, Brian Ó Fearraigh, Mukharbek Organokov, Angelo Orlando, Gogita Papalashvili, Riccardo Papaleo, Cosimo Pastore, Gabriela E. Păvălaş, Giuliano Pellegrini, Carmelo Pellegrino, Mathieu Perrin-Terrin, Paolo Piattelli, Camiel Pieterse, Konstantinos Pikounis, Ofelia Pisanti, Chiara Poirè, Georgia Polydefki, Vlad Popa, Maarten Post, Thierry Pradier, Gerd Pühlhofer, Sara Pulvirenti, Liam Quinn, Fabrizio Raffaelli, Nunzio Randazzo, Antonio Rapicavoli, Soebur Razzaque, Diego Real, Stefan Reck, Jonas Reubelt, Giorgio Riccobene, Marc Richer, Louis Rigalleau, Alberto Rovelli, Ilenia Salvadori, Dorothea F. E. Samtleben, Agustin Sánchez Losa, Matteo Sanguineti, Andrea Santangelo, Domenico Santonocito, Piera Sapienza, Jan-Willem Schmelling, Jutta Schnabel, Virginia Sciacca, Jordan Seneca, Irene Sgura, Rezo Shanidze, Ankur Sharma, Francesco Simeone, Anna Sinopoulou, Bernardino Spisso, Maurizio Spurio, Dimitris Stavropoulos, Jos Steijger, Simona M. Stellacci, Bruno Strandberg, Dominik Stransky, Mauro Taiuti, Yahya Tayalati, Enrique Tenllado, Tarak Thakore, Paul Timmer, Steven Tingay, Ekaterini Tzamariudaki, Dimitrios Tzanetatos, Veronique Van Elewyck, Federico Versari, Salvo Viola, Daniele Vivolo, Gwenhael de Wasseige, Joern Wilms, Rafał Wojaczyński, Els de Wolf, Dmitry Zaborov, Angela Zegarelli, Juan D. Zornoza, Juan Zúñiga, Vasilis Panagopoulos, Fabrizio Ameli, Michel Andre, Giorgos Androulakis, Marco Anghinolfi, Gisela Anton, Miquel Ardid, Julien Aublin, Christos Bagatelas, Giancarlo Barbarino, Bruny Baret, Suzan Basegmez du Pree, Anastasios Belias, Meriem Bendahman, Edward Berbee, Ad M. van den Berg, Vincent Bertin, Vincent van Beveren, Simone Biagi, Andrea Biagioni, Matthias Bissinger, Pascal Bos, Jihad Boumaaza, Simon Bourret, Mohammed Bouta, Gilles Bouvet, Mieke Bouwhuis, Cristiano Bozza, Horea Brânzaş, Max M. Briel, Marc Bruchner, Ronald Bruijn, Jurgen Brunner, Ernst-Jan Buis, Raffaele Buompane, Jose Busto, David Calvo, Antonio Capone, Silvia Celli, Mohamed Chabab, Nhan Chau, Silvio Cherubini, Vitaliano Chiarella, Tommaso Chiarusi, Marco Circella, Rosanna Cocimano, Joao A. B. Coelho, Alexis Coleiro, Marta C. Molla, Stephane Colonges, Rosa Coniglione, Paschal Coyle, Alexandre Creusot, Giacomo Cuttone, Antonio D’Amico, Antonio D’Onofrio, Richard Dallier, Mauro De Palma, Irene Di Palma, Antonio F. Díaz, Didac Diego-Tortosa, Carla Distefano, Alba Domi, Roberto Donà, Corinne Donzaud, Damien Dornic, Manuel Dörr, Mora Durocher, Thomas Eberl, Thijs van Eeden, Imad El Bojaddaini, Hassnae Eljarrari, Dominik Elsaesser, Alexander Enzenhöfer, Paolo Fermani, Giovanna Ferrara, Miroslav D. Filipović, Luigi A. Fusco, Deepak Gajanana, Tamas Gal, Alfonso Garcia Soto, Fabio Garufi, Lucio Gialanella, Emidio Giorgio, Sara R. Gozzini, Rodrigo Gracia, Kay Graf, Dario Grasso, Timothee Grégoire, Giuseppe Grella, Daniel Guderian, Carlo Guidi, Steffen Hallmann, Hassane Hamdaoui, Hans van Haren, Aart Heijboer, Amar Hekalo, Juan J. Hernández-Rey, Jannik Hofestädt, Feifei Huang, Enrique H. Santiago, Giulia Illuminati, Clancy W. James, Peter Jansweijer, Martijn Jongen, Maarten de Jong, Paul de Jong, Matthias Kadler, Piotr Kalaczyński, Oleg Kalekin, Uli F. Katz, Nafis R. Khan Chowdhury, Frits van der Knaap, Els N. Koffeman, Paul Kooijman, Antoine Kouchner, Michael Kreter, Vladimir Kulikovskiy, Robert Lahmann, Giuseppina Larosa, Remy Le Breton, Francesco Leone, Emanuele Leonora, Giuseppe Levi, Massimiliano Lincetto, Miles Lindsey Clark, Alessandro Lonardo, Fabio Longhitano, Daniel Lopez-Coto, Giuliano Maggi, Jerzy Mańczak, Karl Mannheim, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), KM3NeT, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Aiello, Sebastiano, Margiotta, Annarita, Marinelli, Antonio, Markou, Christo, Martignac, Gregory, Martin, Lilian, Martínez-Mora, Juan A., Martini, Agnese, Marzaioli, Fabio, Mazzou, Safaa, Mele, Rosa, Melis, Karel W., Migliozzi, Pasquale, Migneco, Emilio, Mijakowski, Piotr, Miranda, Luis S., Mollo, Carlos M., Morganti, Mauro, Moser, Michael, Moussa, Abdelilah, Muller, Rasa, Musico, Paolo, Musumeci, Mario, Nauta, Lodewijk, Navas, Sergio, Nicolau, Carlo A., Nielsen, Christine, Fearraigh, Brian Ó, Organokov, Mukharbek, Orlando, Angelo, Papalashvili, Gogita, Papaleo, Riccardo, Pastore, Cosimo, Păvălaş, Gabriela E., Pellegrini, Giuliano, Pellegrino, Carmelo, Perrin-Terrin, Mathieu, Piattelli, Paolo, Pieterse, Camiel, Pikounis, Konstantino, Pisanti, Ofelia, Poirè, Chiara, Polydefki, Georgia, Popa, Vlad, Post, Maarten, Pradier, Thierry, Pühlhofer, Gerd, Pulvirenti, Sara, Quinn, Liam, Raffaelli, Fabrizio, Randazzo, Nunzio, Rapicavoli, Antonio, Razzaque, Soebur, Real, Diego, Reck, Stefan, Reubelt, Jona, Riccobene, Giorgio, Richer, Marc, Rigalleau, Loui, Rovelli, Alberto, Salvadori, Ilenia, Samtleben, Dorothea F. E., Sánchez Losa, Agustin, Sanguineti, Matteo, Santangelo, Andrea, Santonocito, Domenico, Sapienza, Piera, Schmelling, Jan-Willem, Schnabel, Jutta, Sciacca, Virginia, Seneca, Jordan, Sgura, Irene, Shanidze, Rezo, Sharma, Ankur, Simeone, Francesco, Sinopoulou, Anna, Spisso, Bernardino, Spurio, Maurizio, Stavropoulos, Dimitri, Steijger, Jo, Stellacci, Simona M., Strandberg, Bruno, Stransky, Dominik, Taiuti, Mauro, Tayalati, Yahya, Tenllado, Enrique, Thakore, Tarak, Timmer, Paul, Tingay, Steven, Tzamariudaki, Ekaterini, Tzanetatos, Dimitrio, Van Elewyck, Veronique, Versari, Federico, Viola, Salvo, Vivolo, Daniele, de Wasseige, Gwenhael, Wilms, Joern, Wojaczyński, Rafał, de Wolf, El, Zaborov, Dmitry, Zegarelli, Angela, Zornoza, Juan D., Zúñiga, Juan, Panagopoulos, Vasili, Ameli, Fabrizio, Andre, Michel, Androulakis, Giorgo, Anghinolfi, Marco, Anton, Gisela, Ardid, Miquel, Aublin, Julien, Bagatelas, Christo, Barbarino, Giancarlo, Baret, Bruny, Basegmez du Pree, Suzan, Belias, Anastasio, Bendahman, Meriem, Berbee, Edward, van den Berg, Ad M., Bertin, Vincent, van Beveren, Vincent, Biagi, Simone, Biagioni, Andrea, Bissinger, Matthia, Bos, Pascal, Boumaaza, Jihad, Bourret, Simon, Bouta, Mohammed, Bouvet, Gille, Bouwhuis, Mieke, Bozza, Cristiano, Brânzaş, Horea, Briel, Max M., Bruchner, Marc, Bruijn, Ronald, Brunner, Jurgen, Buis, Ernst-Jan, Buompane, Raffaele, Busto, Jose, Calvo, David, Capone, Antonio, Celli, Silvia, Chabab, Mohamed, Chau, Nhan, Cherubini, Silvio, Chiarella, Vitaliano, Chiarusi, Tommaso, Circella, Marco, Cocimano, Rosanna, Coelho, Joao A. B., Coleiro, Alexi, Molla, Marta C., Colonges, Stephane, Coniglione, Rosa, Coyle, Paschal, Creusot, Alexandre, Cuttone, Giacomo, D’Amico, Antonio, D’Onofrio, Antonio, Dallier, Richard, De Palma, Mauro, Di Palma, Irene, Díaz, Antonio F., Diego-Tortosa, Didac, Distefano, Carla, Domi, Alba, Donà, Roberto, Donzaud, Corinne, Dornic, Damien, Dörr, Manuel, Durocher, Mora, Eberl, Thoma, van Eeden, Thij, El Bojaddaini, Imad, Eljarrari, Hassnae, Elsaesser, Dominik, Enzenhöfer, Alexander, Fermani, Paolo, Ferrara, Giovanna, Filipović, Miroslav D., Fusco, Luigi A., Gajanana, Deepak, Gal, Tama, Garcia Soto, Alfonso, Garufi, Fabio, Gialanella, Lucio, Giorgio, Emidio, Gozzini, Sara R., Gracia, Rodrigo, Graf, Kay, Grasso, Dario, Grégoire, Timothee, Grella, Giuseppe, Guderian, Daniel, Guidi, Carlo, Hallmann, Steffen, Hamdaoui, Hassane, van Haren, Han, Heijboer, Aart, Hekalo, Amar, Hernández-Rey, Juan J., Hofestädt, Jannik, Huang, Feifei, Santiago, Enrique H., Illuminati, Giulia, James, Clancy W., Jansweijer, Peter, Jongen, Martijn, de Jong, Maarten, de Jong, Paul, Kadler, Matthia, Kalaczyński, Piotr, Kalekin, Oleg, Katz, Uli F., Khan Chowdhury, Nafis R., van der Knaap, Frit, Koffeman, Els N., Kooijman, Paul, Kouchner, Antoine, Kreter, Michael, Kulikovskiy, Vladimir, Lahmann, Robert, Larosa, Giuseppina, Le Breton, Remy, Leone, Francesco, Leonora, Emanuele, Levi, Giuseppe, Lincetto, Massimiliano, Lindsey Clark, Mile, Lonardo, Alessandro, Longhitano, Fabio, Lopez-Coto, Daniel, Maggi, Giuliano, Mańczak, Jerzy, Mannheim, Karl, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Sebastiano Aiello, Fabrizio Ameli, Michel Andre, Giorgos Androulaki, Marco Anghinolfi, Gisela Anton, Miquel Ardid, Julien Aublin, Christos Bagatela, Giancarlo Barbarino, Bruny Baret, Suzan Basegmez du Pree, Anastasios Belia, Meriem Bendahman, Edward Berbee, Ad M. van den Berg, Vincent Bertin, Vincent van Beveren, Simone Biagi, Andrea Biagioni, Matthias Bissinger, Pascal Bo, Jihad Boumaaza, Simon Bourret, Mohammed Bouta, Gilles Bouvet, Mieke Bouwhui, Cristiano Bozza, Horea Brânza, Max M. Briel, Marc Bruchner, Ronald Bruijn, Jurgen Brunner, Ernst-Jan Bui, Raffaele Buompane, Jose Busto, David Calvo, Antonio Capone, Silvia Celli, Mohamed Chabab, Nhan Chau, Silvio Cherubini, Vitaliano Chiarella, Tommaso Chiarusi, Marco Circella, Rosanna Cocimano, Joao A. B. Coelho, Alexis Coleiro, Marta C. Molla, Stephane Colonge, Rosa Coniglione, Paschal Coyle, Alexandre Creusot, Giacomo Cuttone, Antonio D’Amico, Antonio D’Onofrio, Richard Dallier, Mauro De Palma, Irene Di Palma, Antonio F. Díaz, Didac Diego-Tortosa, Carla Distefano, Alba Domi, Roberto Donà, Corinne Donzaud, Damien Dornic, Manuel Dörr, Mora Durocher, Thomas Eberl, Thijs van Eeden, Imad El Bojaddaini, Hassnae Eljarrari, Dominik Elsaesser, Alexander Enzenhöfer, Paolo Fermani, Giovanna Ferrara, Miroslav D. Filipovic ́, Luigi A. Fusco, Deepak Gajanana, Tamas Gal, Alfonso Garcia Soto, Fabio Garufi, Lucio Gialanella, Emidio Giorgio, Sara R. Gozzini, Rodrigo Gracia, Kay Graf, Dario Grasso, Timothee Grégoire, Giuseppe Grella, Daniel Guderian, Carlo Guidi, Steffen Hallmann, Hassane Hamdaoui, Hans van Haren, Aart Heijboer, Amar Hekalo, Juan J. Hernández-Rey, Jannik Hofestädt, Feifei Huang, Enrique H. Santiago, Giulia Illuminati, Clancy W. Jame, Peter Jansweijer, Martijn Jongen, Maarten de Jong, Paul de Jong, Matthias Kadler, Piotr Kalaczynski, Oleg Kalekin, Uli F. Katz, Nafis R. Khan Chowdhury, Frits van der Knaap, Els N. Koffeman, Paul Kooijman, Antoine Kouchner, Michael Kreter, Vladimir Kulikovskiy, Robert Lahmann, Giuseppina Larosa, Remy Le Breton, Francesco Leone, Emanuele Leonora, Giuseppe Levi, Massimiliano Lincetto, Miles Lindsey Clark, Alessandro Lonardo, Fabio Longhitano, Daniel Lopez-Coto, Giuliano Maggi, Jerzy Ma ́nczak, Karl Mannheim, Annarita Margiotta, Antonio Marinelli, Christos Markou, Gregory Martignac, Lilian Martin, Juan A. Martínez-Mora, Agnese Martini, Fabio Marzaioli, Safaa Mazzou, Rosa MeleKarel W. Meli, Pasquale Migliozzi, Emilio Migneco, Piotr Mijakowski, Luis S. Miranda, Carlos M. Mollo, Mauro Morganti, Michael Moser, Abdelilah Moussa, Rasa Muller, Paolo Musico, Mario Musumeci, Lodewijk Nauta, Sergio Nava, Carlo A. Nicolau, Christine Nielsen, Brian Ó Fearraigh, Mukharbek Organokov, Angelo Orlando, Vasilis Panagopoulo, Gogita Papalashvili, Riccardo Papaleo, Cosimo Pastore, Gabriela E. Păvăla ̧, Giuliano Pellegrini, Carmelo Pellegrino, Mathieu Perrin-Terrin, Paolo Piattelli, Camiel Pieterse, Konstantinos Pikouni, Ofelia Pisanti, Chiara Poirè, Georgia Polydefki, Vlad Popa, Maarten Post, Thierry Pradier, Gerd Pühlhofer, Sara Pulvirenti, Liam Quinn, Fabrizio Raffaelli, Nunzio Randazzo, Antonio Rapicavoli, Soebur Razzaque, Diego Real, Stefan Reck, Jonas Reubelt, Giorgio Riccobene, Marc Richer, Louis Rigalleau, Alberto Rovelli, Ilenia Salvadori, Dorothea F. E. Samtleben, Agustin Sánchez Losa, Matteo Sanguineti, Andrea Santangelo, Domenico Santonocito, Piera Sapienza, Jan-Willem Schmelling, Jutta Schnabel, Virginia Sciacca, Jordan Seneca, Irene Sgura, Rezo Shanidze, Ankur Sharma, Francesco Simeone, Anna Sinopoulou, Bernardino Spisso, Maurizio Spurio, Dimitris Stavropoulo, Jos Steijger, Simona M. Stellacci, Bruno Strandberg, Dominik Stransky, Mauro Taiuti, Yahya Tayalati, Enrique Tenllado, Tarak Thakore, Paul Timmer, Steven Tingay, Ekaterini Tzamariudaki, Dimitrios Tzanetato, Veronique Van Elewyck, Federico Versari, Salvo Viola, Daniele Vivolo, Gwenhael de Wasseige, Joern Wilm, Rafał Wojaczy ́nski, Els de Wolf, Dmitry Zaborov, Angela Zegarelli, Juan D. Zornoza, Juan Zúñiga, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Ministerio de Economía y Competitividad (España), Ministerio de Ciencia, Innovación y Universidades (España), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Research unit Astroparticle Physics, and 33379009 - Kreter, Michael
Subjects: Astrofísica, data acquisition, Computer science, Physics::Instrumentation and Detectors, readout electronics, sensors, Astrophysics, Neutrino telescope, computer.software_genre, 7. Clean energy, 01 natural sciences, Signal, Synchronization (alternating current), Front and back ends, Front-end electronics, readout electronics, neutrino telescope, KM3NeT, Front-end electronics, KM3NeT, Readout electronics, 010303 astronomy & astrophysics, Instrumentation, field programmable gate arrays, Firmware, electronics, 4. Education, Electrical engineering, Astrophysics::Instrumentation and Methods for Astrophysics, front-end electronics, Electronic, Optical and Magnetic Materials, Astrophysics - Instrumentation and Methods for Astrophysics, Photomultiplier, clocks, front-end electronic, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Partícules (Física nuclear), 010309 optics, 0103 physical sciences, Neutrins, readout electronic, 14. Life underwater, Electronics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), Cherenkov radiation, Particles (Nuclear physics), Detectors òptics, logic, Optical detectors, Física [Àrees temàtiques de la UPC], Telescopis, business.industry, Mechanical Engineering, neutrino telescope, Astronomy and Astrophysics, Space and Planetary Science, Control and Systems Engineering, FISICA APLICADA, business, computer, Telescopes
Abstract: [EN] The KM3NeT research infrastructure being built at the bottom of the Mediterranean Sea will host water-Cherenkov telescopes for the detection of cosmic neutrinos. The neutrino telescopes will consist of large volume three-dimensional grids of optical modules to detect the Cherenkov light from charged particles produced by neutrino-induced interactions. Each optical module houses 31 3-in. photomultiplier tubes, instrumentation for calibration of the photomultiplier signal and positioning of the optical module, and all associated electronics boards. By design, the total electrical power consumption of an optical module has been capped at seven Watts. We present an overview of the front-end and readout electronics system inside the optical module, which has been designed for a 1-ns synchronization between the clocks of all optical modules in the grid during a life time of at least 20 years., The authors acknowledge financial support from the funding agencies: Agence Nationale de la Recherche (Grant No. ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (Grant Nos. ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Paris Ile-de-France Region, France; Shota Rustaveli National Science Foundation of Georgia (SRNSFG, Grant No. FR-18-1268), Georgia; Deutsche Forschungsgemeinschaft (DFG), Germany; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), PRIN 2017 program (Grant NAT-NET 2017W4HA7S) Italy; Ministry of Higher Education, Scientific Research and Professional Training, Morocco; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; The National Science Centre, Poland (2015/18/E/ST2/00758); National Authority for Scientific Research (ANCS), Romania; Plan Estatal de Investigacion [refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)], Severo Ochoa Centre of Excellence program (MINECO), Red Consolider MultiDark (ref. FPA2017-90566-REDC, MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), "la Caixa" Foundation (ID 100010434) through the fellowship LCF/BQ/IN17/11620019, and the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 713673, Spain.
Published: 2019
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11. Effects of sildenafil on right ventricle remodelling in Portopulmonary hypertension

Author: Giuseppe Boriani, Marisa Talarico, F Sgura, Daniel Monopoli, Rosario Rossi, Francesca Coppi, Roberto Minici, and Filippo Schepis
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Sildenafil, Ventricular Dysfunction, Right, Population, Diastole, Porto-pulmonary hypertension pulmonary, Pulmonary arterial hypertension, Sildenafil Citrate, chemistry.chemical_compound, Internal medicine, medicine, Humans, Prognosis, Right heart catheterization, Right ventricle, Pharmacology (medical), education, Macitentan, Pulmonary Arterial Hypertension, education.field_of_study, Portopulmonary hypertension, Ejection fraction, Ventricular Remodeling, business.industry, Biochemistry (medical), Stroke Volume, Stroke volume, medicine.disease, chemistry, Hypertension, Cardiology, Portal hypertension, business
Abstract: Portopulmonary hypertension (PoPH) is a clinical condition associated with end-stage liver disease, described by the coexistence of pulmonary arterial hypertension (PAH) and portal hypertension. In PoPH patients, there is a right ventricle (RV) remodeling to compensate for the increased resistance in the lung circulation. There are no studies on the effects of the PAH-targeted pharmacological treatment on the RV dimension and function. The present study summarizes our experience in patients with PoPH treated with sildenafil in a period of 6 years (from 2013 to 2019). We enrolled 64 consecutive patients identified as PoPH, all treated with sildenafil (57.6% in monotherapy; in the other cases in association with macitentan; in 19.0% with initial combination therapy). A hemodynamic invasive cardiopulmonary study was performed at baseline and after 6 months of sildenafil treatment. In our population we showed a significative improvement in RV performance, with a significant increase in RV stroke volume (+33%), RV ejection fraction (+31%) and RV stroke work index (+17.5%). We registered the reduction of the RV cavity dimension over time in all patients treated with sildenafil (RV end diastolic diameter decreased by 15% after 6 months of follow-up). Regarding diastolic function, we highlighted a very significant reduction in RV end-diastolic pressure (-50% concerning baseline). Sildenafil was effective both when used as monotherapy and in combination with macitentan. In conclusion, Sildenafil had a positive impact on RV systolic and diastolic function in patients with PoPH and was able to conditionate the reverse remodeling of the RV.
Published: 2021

12. Impact of body mass index on the outcome of elderly patients treated with transcatheter aortic valve implantation

Author: Giuseppe Boriani, Paolo Magnavacchi, Rosario Rossi, Luigi Vignali, Stefano Tondi, Davide Gabbieri, Vincenzo Guiducci, F Sgura, Marco Vitolo, Daniel Monopoli, Giorgio Benatti, Salvatore Arrotti, and Anna Chiara Valenti
Subjects: Male, medicine.medical_specialty, Overweight, Body Mass Index, Transcatheter Aortic Valve Replacement, Thinness, Risk Factors, Internal medicine, Aortic valve stenosis, Body mass index, Cardiovascular disease, Obesity paradox, TAVI, Internal Medicine, Medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Mortality rate, Hazard ratio, nutritional and metabolic diseases, Aortic Valve Stenosis, medicine.disease, Confidence interval, Treatment Outcome, Aortic Valve, Emergency Medicine, Cardiology, Female, medicine.symptom, Underweight, business
Abstract: Underweight or overweight patients with cardiovascular diseases are associated with different outcomes. However, the data on the relation between body mass index (BMI) and outcomes after transcatheter aortic valve implantation (TAVI) are not homogeneous. The aim of this study was to assess the role of low BMI on short and long-term mortality in real-world patients undergoing TAVI. We retrospectively included patients undergoing TAVI for severe aortic valve stenosis. Patients were classified into three BMI categories: underweight (
Published: 2021

13. Trans-catheter valve implantation and patient outcomes: Focus on the kidney

Author: Paolo Magnavacchi, Salvo Arrotti, Giuseppe Boriani, F Sgura, and Davide Gabbieri
Subjects: medicine.medical_specialty, Kidney, Focus (computing), Acute kidney injury, Aortic stenosis, Chronic kidney disease, Outcome, Transcatheter aortic valve implantation, Catheters, business.industry, Aortic Valve Stenosis, medicine.disease, Surgery, Transcatheter Aortic Valve Replacement, Catheter, medicine.anatomical_structure, Aortic Valve, Internal Medicine, Medicine, Humans, business
Published: 2021

14. Tricento Transcatheter Heart Valve for Severe Tricuspid Regurgitation

Author: Alaide Chieffo, Marco Ancona, Francesco Moroni, Vittorio Romano, Francesco Ancona, F Sgura, Eustachio Agricola, Barbara Bellini, Mauro Carlino, Alessandro Beneduce, Matteo Montorfano, Luca A. Ferri, and Saud Khawaja
Subjects: medicine.medical_specialty, medicine.diagnostic_test, business.industry, Peripheral edema, Computed tomography, Regurgitation (circulation), 030204 cardiovascular system & hematology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Aortic valve replacement, Internal medicine, Heart failure, medicine, Cardiology, Chronic atrial fibrillation, 030212 general & internal medicine, Heart valve, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: An 82-year-old woman with chronic atrial fibrillation, previous aortic valve replacement with a self-expandable transcatheter heart valve (THV), and multiple hospitalizations for congestive heart failure presented to our institution with diuretic-resistant peripheral edema and New York Heart
Published: 2019
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15. Establishment and characterization of induced pluripotent stem cells (iPSCs) from central nervous system lupus erythematosus

Author: Elvira Immacolata Parrotta, Sara Gasparini, Giovanni Cuda, Antonella Sgura, Umberto Aguglia, Maria Teresa De Angelis, Stefania Scalise, Gianluca Santamaria, Edoardo Ferlazzo, Clara Ciampi, Michela Lo Conte, De Angelis, Maria Teresa, Santamaria, Gianluca, Parrotta, Elvira Immacolata, Scalise, Stefania, Lo Conte, Michela, Gasparini, Sara, Ferlazzo, Edoardo, Aguglia, Umberto, Ciampi, Clara, Sgura, Antonella, and Cuda, Giovanni
Subjects: 0301 basic medicine, MAPK/ERK pathway, induced pluripotent stem cells, Central nervous system, central nervous system-systemic lupus erythematosu, Gene Expression, Disease, Bioinformatics, 03 medical and health sciences, 0302 clinical medicine, microRNA, medicine, Humans, Lupus Erythematosus, Systemic, Induced pluripotent stem cell, skin and connective tissue diseases, Protein kinase B, Lupus erythematosus, biology, business.industry, Lupus Vasculitis, Central Nervous System, S100A10, biomarkers, Cell Biology, Original Articles, medicine.disease, MicroRNAs, Oxidative Stress, 030104 developmental biology, medicine.anatomical_structure, central nervous system‐systemic lupus erythematosus, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, biomarker, Original Article, Female, business, Signal Transduction
Abstract: Involvement of the central nervous system (CNS) is an uncommon feature in systemic lupus erythematosus (SLE), making diagnosis rather difficult and challenging due to the poor specificity of neuropathic symptoms and neurological symptoms. In this work, we used human‐induced pluripotent stem cells (hiPSCs) derived from CNS‐SLE patient, with the aim to dissect the molecular insights underlying the disease by gene expression analysis and modulation of implicated pathways. CNS‐SLE‐derived hiPSCs allowed us to provide evidence of Erk and Akt pathways involvement and to identify a novel cohort of potential biomarkers, namely CHCHD2, IDO1, S100A10, EPHA4 and LEFTY1, never reported so far. We further extended the study analysing a panel of oxidative stress‐related miRNAs and demonstrated, under normal or stress conditions, a strong dysregulation of several miRNAs in CNS‐SLE‐derived compared to control hiPSCs. In conclusion, we provide evidence that iPSCs reprogrammed from CNS‐SLE patient are a powerful useful tool to investigate the molecular mechanisms underlying the disease and to eventually develop innovative therapeutic approaches.
Published: 2019

16. Genomic damage induced by 1-MHz ultrasound in vitro

Author: Raffaele Palomba, Jessica Marinaccio, Angelico Bedini, Antonella Sgura, Ion Udroiu, and Claudia Giliberti
Subjects: 0301 basic medicine, Genetics, Therapeutic ultrasound, Epidemiology, DNA damage, business.industry, Health, Toxicology and Mutagenesis, medicine.medical_treatment, Ultrasound, Aneuploidy, Mutagen, Biology, medicine.disease_cause, medicine.disease, Spindle apparatus, 03 medical and health sciences, Clastogen, 030104 developmental biology, 0302 clinical medicine, 030220 oncology & carcinogenesis, Micronucleus test, medicine, Cancer research, business, Genetics (clinical)
Abstract: Genotoxic effects of therapeutic ultrasound are poorly documented, when compared with the wide use of this physical agent. The aim of this work was to investigate the clastogenic and aneugenic potential of 1 MHz ultrasound, employing intensities (200 and 300 mW/cm2 ) above the cavitational threshold, but in the range of those normally used in therapeutics. Both normal fibroblasts (AG01522) and tumoral cells (MCF-7) were sonicated. While no effects on viability were noted, significant increases of CREST-negative micronuclei (indicative of clastogenesis) and CREST-positive micronuclei (indicative of aneuploidy) were detected. Clastogenesis was confirmed by increases of γ-H2AX foci, while increases of spindle anomalies confirmed the induction of aneuploidy. Our results confirm previous works that showed ultrasound-induced DNA breakage. Moreover, our experiments show that the known effect of ultrasound-induced damage to microtubules is also able to damage the mitotic spindle and induce aneuploidy. On the overall, this work highlights the importance to further investigate the potential risks related to therapeutics US. Environ. Mol. Mutagen. 59:60-68, 2018. © 2017 Wiley Periodicals, Inc.
Published: 2017
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17. TAVR in a patient with an anomalous left main: Self-expanding prosthesis might be the preferred choice

Author: Barbara Bellini, Matteo Montorfano, Vittorio Romano, Fabio Sgura, Marco Ancona, and Georgios Tzanis
Subjects: lcsh:Diseases of the circulatory (Cardiovascular) system, medicine.medical_specialty, business.industry, medicine.medical_treatment, Aortic Valve Stenosis, Prosthesis Design, Prosthesis, Surgery, Transcatheter Aortic Valve Replacement, Treatment Outcome, lcsh:RC666-701, Risk Factors, Aortic Valve, Heart Valve Prosthesis, medicine, Humans, Cardiology and Cardiovascular Medicine, business
Published: 2020
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18. Cost-effectiveness of the coronary sinus Reducer and its impact on the healthcare burden of refractory angina patients

Author: Luca Baldetti, Francesco Ponticelli, Fabio Sgura, Geert E. Leenders, Antonio Colombo, Pieter R. Stella, Leo Timmers, Gianluca Campo, Carlo Zivelonghi, Stefan Verheye, Maurizio Tespili, Patrizio Armeni, Liesbeth Rosseel, Giuseppe Tarantini, Pierfrancesco Agostoni, Guglielmo Gallone, Francesco Giannini, Alfonso Ielasi, Matteo Tebaldi, and Gianpiero D'Amico
Subjects: Male, Quality of life, medicine.medical_specialty, Percutaneous, Cost effectiveness, Cost-Benefit Analysis, 030204 cardiovascular system & hematology, NO, Angina Pectoris, 03 medical and health sciences, 0302 clinical medicine, Health care, Humans, Medicine, 030212 general & internal medicine, Coronary sinus, Aged, Retrospective Studies, Reducer, business.industry, Coronary sinus Reducer, Health Policy, Coronary Sinus, Chronic refractory angina, Cost-effectiveness analysis, Middle Aged, Patient Acceptance of Health Care, Healthcare costs, Electrodes, Implanted, Cost-effectiveness, Quality-adjusted life year, Treatment Outcome, CHRONIC REFRACTORY ANGINA, CORONARY SINUS REDUCER, COST-EFFECTIVENESS, HEALTHCARE COSTS, QUALITY OF LIFE, Emergency medicine, Female, Quality-Adjusted Life Years, business, Cardiology and Cardiovascular Medicine, Delivery of Health Care
Abstract: AIMS: The coronary sinus Reducer is a percutaneous device proven to improve angina symptoms in refractory angina (RA). We evaluated its potential cost-effectiveness and impact on the healthcare resource use. METHODS AND RESULTS: Angina-related healthcare resource usage and quality-of-life data were collected for 215 consecutive RA patients undergoing Reducer implantation in Belgium, the Netherlands, and Italy. Costs were assessed from each country's healthcare system perspective. Data from the date of RA diagnosis to Reducer implantation [Standard-of-Care (SoC)-period] and from Reducer implantation to follow-up (Reducer-period) were compared: during Reducer-period, a significant reduction in angina-driven hospitalizations, outpatient visits, coronary angiograms, and percutaneous coronary interventions per patient-year was observed, translating into significantly reduced costs per patient-year. To assess cost-effectiveness, costs and utilities of 1-year SoC were compared with those of 1-year Reducer-period. Assumptions on Reducer efficacy duration were further explored with modelled projections. Reducer was associated with higher quality-adjusted life years (QALYs: 0.665 vs. 0.580, P
Published: 2020

19. Kidney dysfunction and short term all-cause mortality after transcatheter aortic valve implantation

Author: Luigi Vignali, Giuseppe Boriani, Paolo Magnavacchi, F Sgura, Andrea Denegri, Davide Gabbieri, Daniel Monopoli, Vincenzo Guiducci, Salvatore Arrotti, Stefano Tondi, Federico Banchelli, and Roberto D'Amico
Subjects: Kidney, medicine.medical_specialty, Transcatheter aortic, urogenital system, business.industry, Kidney dysfunction, Acute kidney injury, 030204 cardiovascular system & hematology, urologic and male genital diseases, medicine.disease, aortic stenosis, chronic kidney disease, TAVI, female genital diseases and pregnancy complications, 03 medical and health sciences, Stenosis, 0302 clinical medicine, medicine.anatomical_structure, Internal medicine, Internal Medicine, Cardiology, Clinical endpoint, Medicine, 030212 general & internal medicine, business, All cause mortality, Kidney disease
Abstract: Background Acute kidney injury (AKI) after transcatheter aortic valve implantation (TAVI) has been associated with worse outcomes. However, the impact on outcome of AKI in TAVI-patients is not well established. Methods Inoperable patients with severe aortic stenosis (AS) undergoing TAVI in 2010-2018 were enrolled in this study. AKI and chronic kidney disease (CKD) were defined according to KDIGO guidelines. Patients were divided in two groups according to post-procedural AKI development. The primary endpoint was 30-day all-cause mortality across the two groups. Results A total of 373 patients (mean age 82.3 ± 6) were analyzed. Compared to non-AKI patients, those who developed AKI, were treated more frequently with trans-apical TAVI (66% vs 35%, p Conclusion In our analysis, AKI was a strong predictor of 30-day all-cause mortality. Particularly, patients with severe CKD with AKI showed the highest 30-day mortality risk. Thus, this group of patients might benefit from closer monitoring and specific kidney protection therapies.
Published: 2020

20. Complicated myocardial infarction in a 99-year-old lady in the era of COVID-19 pandemic: from the need to rule out coronavirus infection to emergency percutaneous coronary angioplasty

Author: Carlo Giuseppe Cappello, Salvatore Arrotti, Giuseppe Boriani, and F Sgura
Subjects: medicine.medical_specialty, Percutaneous, Coronavirus disease 2019 (COVID-19), medicine.medical_treatment, Pneumonia, Viral, Myocardial Infarction, MEDLINE, Acute myocardial infarction, Coronary Angiography, medicine.disease_cause, Percutaneous coronary intervention, Diagnosis, Differential, Betacoronavirus, Electrocardiography, Elderly, Angioplasty, Pandemic, medicine, Internal Medicine, Humans, Myocardial infarction, Angioplasty, Balloon, Coronary, Pandemics, Coronavirus, Aged, 80 and over, SARS-CoV-2, business.industry, COVID-19, medicine.disease, Echocardiography, Emergency, Infection, Emergency medicine, Emergency Medicine, Female, Coronavirus Infections, business, Im - Case Record
Published: 2020

21. Structural modeling of a novel TERC variant in a patient with aplastic anemia and short telomeres

Author: Emanuele Agolini, Paola Grammatico, Antonio Novelli, Anna Paola Iori, Emanuele Bellacchio, Silvia Majore, Martina Rinelli, F. Berardinelli, Giulia Pascolini, L. Quattrocchi, and A. Sgura
Subjects: Oncology, medicine.medical_specialty, Hematology, business.industry, Anemia, Heterozygote advantage, General Medicine, medicine.disease, Telomere, Internal medicine, Medicine, Aplastic anemia, business
Published: 2018
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22. P1517Risk of acute kidney injury in transcatheter aortic valve implantation procedures and impact on 30-day outcome

Author: Marco Vitolo, D Gabbieri, F Sgura, Stefano Tondi, Salvatore Arrotti, G Boriani, Paolo Magnavacchi, A Pennacchioni, and A Autieri
Subjects: medicine.medical_specialty, Transcatheter aortic, business.industry, medicine, Acute kidney injury, Cardiology and Cardiovascular Medicine, medicine.disease, business, Surgery
Abstract: Background Transcatheter aortic valve implantation (TAVI) is a safe and effective procedure for patients with symptomatic aortic stenosis who do not qualify for surgery. Nevertheless, post-procedure acute kidney injury (AKI) is a frequent complication and it is associated with worse outcomes. Aim To assess the impact of acute kidney injury (AKI) occurring immediately after the TAVI procedure on patients' outcome. Methods We conducted a multicenter retrospective study on patients treated with TAVI from 2010 to 2018. The assigned treatment, the selection of the device (self-expandable/balloon-expandable valve) and the type of approach used were determined by each individual Center on the basis of the patient's characteristics and the choice of the operator. All patients had an intermediate or high Society of Thoracic Surgeons (STS) score. Basal creatinine and glomerular filtrate (using the body mass index, sex and age) were evaluated for each patient. According to the KDIGO criteria, AKI is defined as an increase in serum creatinine (SCr) ≥0,3mg/dl within 48 hours or an increase in SCr ≥1.5 times baseline or urine volume Results A total of 371 pts were analysed. Mean age was 82.3±5.9 and the majority of the pts had an STS score>10 (97.6%). Incidence of Acute kidney Injury (AKI) stage 3 post TAVI, according to VARC-2 criteria, was 16,2%. In patient with AKI, the hospitalization time was longer 18,7±6,1 days vs 8,4±6,1 days without AKI (p AKI and short term mortality Conclusion Acute kidney injury is a frequent complication after TAVI. AKI seems to be the strongest predictor for 30 day mortality and increases the hospitalization time. AKI was more common in patients treated with a transapical approach or if they presented a PAD. In contrast, pre-procedural chronic kidney disease did not seem to correlate directly with an increased risk of AKI.
Published: 2019
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23. Characterisation of the Hamamatsu photomultipliers for the KM3NeT Neutrino Telescope

Author: Carmelo Pellegrino, F. Garufi, S.E. Akrame, A. Martini, U. Katz, Stavroula Tsagkli, D. van Eijk, T. Stüven, Rosanna Cocimano, A. Orlando, M. Anghinolfi, Piotr Kalaczyński, Vladimir Kulikovskiy, P. Timmer, Luigi Antonio Fusco, Maurizio Spurio, L. de Waardt, A.J. Heijboer, Rezo Shanidze, R. Gracia Ruiz, M. Jongen, F. Versari, J. Manczak, B. Schermer, Alessia Capone, P.M. Kooijman, J. Brunner, T. Gal, E. Migneco, B. Spisso, M. Richer, C. Distefano, Raffaele Buompane, Robert Lahmann, Lucio Gialanella, J. Seneca, E. Buis, Els Koffeman, D. F. E. Samtleben, A. Hekalo, A. Trovato, D. Tzanetatos, P. Migliozzi, Cristiano Bozza, E. Berbee, I. Di Palma, G. Ferrara, B. Jongewaard, Antonio F. Díaz, D. Zaborov, Paolo Sapienza, H. van Haren, S. Geißelsöder, Sebastiano Aiello, G. Pühlhofer, T. Avgitas, Fabio Longhitano, M. Taiuti, G. E. Poma, Francesco Simeone, G. Polydefki, R. Donà, L. Nauta, S. Loucatos, B. Vallage, G. Grella, G. Maggi, Carlos Maximiliano Mollo, P. Mijakowski, Tommaso Chiarusi, M. Perrin-Terrin, Matteo Sanguineti, Robert Muller, Massimiliano Lincetto, Alessandro Lonardo, S. Bourret, J. Barrios-Martí, Giuseppe Levi, Silvia Celli, V. Sciacca, M. Dörr, Thierry Pradier, Carlo Alessandro Nicolau, G. Riccobene, S.F. Biagi, E. A. De Wolf, G.E. Păvălaş, Emanuele Leonora, O. Kalekin, Michel André, C. Poirè, Corinne Donzaud, A. Marinelli, R. Coniglione, A. Sánchez Losa, I. El Bojaddaini, V. Bertin, A. Belias, A.M. van den Berg, V. Van Elewyck, Kay Graf, Karel Melis, J.D. Zornoza, E. Tenllado, C. De Sio, Antoine Kouchner, Mohamed Chabab, Antonio D'Onofrio, J. Hofestädt, Michael Moser, L. S. Miranda, Fabio Marzaioli, F. Raffaelli, M.C. Bouwhuis, Matthias Kadler, Daniele Vivolo, Jörn Wilms, Richard Dallier, H. Brânzaş, Giulia Illuminati, Alba Domi, D. Calvo, Jihad Boumaaza, Andrea Santangelo, R. Bormuth, Diego Real, R. Le Breton, M. Baars, I. Sgura, M. Colomer Molla, Salvatore Viola, Soebur Razzaque, Sara Pulvirenti, Thomas Eberl, P. Piattelli, M. Lotze, A. Sharma, Ofelia Pisanti, M. Volkert, Vitaliano Chiarella, G. Kieft, S. Navas, Jose Busto, A. Enzenhöfer, J. Reubelt, T. Heid, Mario Musumeci, D. Kießling, T. Grégoire, L. K. Resvanis, P. de Jong, C. Biernoth, V. Popa, T. Thakore, N. Randazzo, J. Zúñiga, D. Stavropoulos, M. Organokov, C. Nielsen, N. R. Khan Chowdhury, B. Strandberg, Damien Dornic, Jos Steijger, V. Panagopoulos, Simona Maria Stellacci, J. Aublin, A. Rovelli, Abdelilah Moussa, M. de Jong, R. Mele, J.A. Martínez-Mora, Alexis Coleiro, Michael Kreter, Dario Grasso, Fabrizio Ameli, Steffen Hallmann, Joao A B Coelho, Francesca Tatone, R. Bruijn, Emidio Giorgio, E. G. Anassontzis, C. Bagatelas, M. Ardid, J. Pérez Romero, Dominik Elsaesser, L. Quinn, L. Martin, I. Salvadori, C. W. James, Annarita Margiotta, Gisela Anton, Bruny Baret, S. R. Gozzini, M. Post, K. Pikounis, A. Creusot, N. Briukhanova, C. Markou, E. Tzamariudaki, Claudia Valieri, Riccardo Papaleo, A. Giuliante, G. C. Barbarino, J.J. Hernández-Rey, Yahya Tayalati, M. Durocher, G. Androulakis, Silvio Cherubini, S. Gauchery, L. Caramete, G. Papalashvili, D. Stransky, M. Circella, Karl Mannheim, Andrea Biagioni, G. Pellegrini, A. Sinopoulou, M. Morganti, P. Coyle, Giacomo Cuttone, Francesco Leone, AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, KM3NeT, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Aiello, S., Akrame, S. E., Ameli, F., Anassontzis, E. G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Aublin, J., Avgitas, T., Baars, M., Bagatelas, C., Barbarino, G., Baret, B., Barrios-Martí, J., Belias, A., Berbee, E., Berg, A. Van Den, Bertin, V., Biagi, S., Biagioni, A., Biernoth, C., Bormuth, R., Boumaaza, J., Bourret, S., Bouwhuis, M., Bozza, C., Branzaş, H., Briukhanova, N., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Calvo, D., Capone, A., Caramete, L., Celli, S., Chabab, M., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cuttone, G., D'Onofrio, A., Dallier, R., Sio, C. De, Palma, I. Di, Díaz, A. F., Distefano, C., Domi, A., Donà, R., Donzaud, C., Dornic, D., Dörr, M., Durocher, M., Eberl, T., Eijk, D. Van, Bojaddaini, I. El, Elsaesser, D., Enzenhöfer, A., Ferrara, G., Fusco, L. A., Gal, T., Garufi, F., Gauchery, S., Geißelsöder, S., Gialanella, L., Giorgio, E., Giuliante, A., Gozzini, S. R., Ruiz, R. Gracia, Graf, K., Grasso, D., Grégoire, T., Grella, G., Hallmann, S., Haren, H. Van, Heid, T., Heijboer, A., Hekalo, A., Hernández-Rey, J. J., Hofestädt, J., Illuminati, G., James, C. W., Jongen, M., Jongewaard, B., De Jong, M., De Jong, P., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Breton, R. Le, Leone, F., Leonora, E., Levi, G., Lincetto, M., Lonardo, A., Longhitano, F., Lotze, M., Loucatos, S., Maggi, G., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mele, R., Melis, K. W., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nielsen, C., Organokov, M., Orlando, A., Panagopoulos, V., Papalashvili, G., Papaleo, R., Pǎvǎlaş, G. E., Pellegrini, G., Pellegrino, C., Pérez Romero, J., Perrin-Terrin, M., Piattelli, P., Pikounis, K., Pisanti, O., Poirè, C., Polydefki, G., Poma, G. E., Popa, V., Post, M., Pradier, T., Pühlhofer, G., Pulvirenti, S., Quinn, L., Raffaelli, F., Randazzo, N., Razzaque, S., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Richer, M., Rovelli, A., Salvadori, I., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Sapienza, P., Schermer, B., Sciacca, V., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Simeone, F., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Steijger, J., Stellacci, S. M., Strandberg, B., Stransky, D., Stüven, T., Taiuti, M., Tatone, F., Tayalati, Y., Tenllado, E., Thakore, T., Timmer, P., Trovato, A., Tsagkli, S., Tzamariudaki, E., Tzanetatos, D., Valieri, C., Vallage, B., Elewyck, V. Van, Versari, F., Viola, S., Vivolo, D., Volkert, M., De Waardt, L., Wilms, J., De Wolf, E., Zaborov, D., Zornoza, J. D., Zuniga, J., Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Mollo, Carlos Maximiliano, Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), KM3NeT (IHEF, IoP, FNWI), IHEF (IoP, FNWI), ATLAS (IHEF, IoP, FNWI), Akrame, S.E., Anassontzis, E.G., Coelho, J.A.B., Díaz, A.F., Fusco, L.A., Gozzini, S.R., Hernández-Rey, J.J., James, C.W., Katz, U.F., Chowdhury, N.R. Khan, Koffeman, E.N., Martínez-Mora, J.A., Melis, K.W., Miranda, L.S., Mollo, C.M., Nicolau, C.A., Pǎvǎlaş, G.E., Poma, G.E., Samtleben, D.F.E., Stellacci, S.M., and Zornoza, J.D.
Subjects: Astrofísica, Tubs, PROTOTYPE, Physics::Instrumentation and Detectors, Física::Física de partícules [Àrees temàtiques de la UPC], Particle detectors, High Tech Systems & Materials, Astrophysics, 01 natural sciences, Neutrino detector, Photon detectors for UV, visible and IR photons (vacuum), Large detector systems, Neutrino detectors, Instrumentation, KM3NeT, Photon detectors for UV, Mathematical Physics, photoelectron: yield, Physics, photomultiplier, Industrial Innovation, Peak-to-valley ratios, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Particle physics, Photodetectors, efficiency: quantum, Cherenkov counters, Cherenkov detectors, Large detector systems for particle and astroparticle physics, Dark count rate, Quantum efficiency, Física nuclear, Optoelectrònica, performance, Cherenkov detector, Cherenkov detectors, Large detector systems for particle and astroparticle physics, Neutrino detectors, Photon detectors for UV, visible and IR photons (vacuum), Instrumentation, Mathematical Physics, Photomultiplier, Fotònica, Phase (waves), Photodetector, Partícules (Física nuclear), Optics, Photo multiplier tube, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Optoelectronics, 010306 general physics, numerical calculations, Particles (Nuclear physics), Astroparticle physics, 010308 nuclear & particles physics, business.industry, Herenkov detectors, visible and IR photons (vacuum), Photomultipliers, Photonics, FISICA APLICADA, Large detector systems for particle and astroparticle physic, Òptica -- Aparells i instruments, Neutrino telescopes, Photon detectors for UV,visible and IR photons (vacuum), business, Telescopes
Abstract: [EN] The Hamamatsu R12199-02 3-inch photomultiplier tube is the photodetector chosen for the first phase of the KM3NeT neutrino telescope. About 7000 photomultipliers have been characterised for dark count rate, timing spread and spurious pulses. The quantum eÿciency, the gain and the peak-to-valley ratio have also been measured for a sub-sample in order to determine parameter values needed as input to numerical simulations of the detector., The authors acknowledge the financial support of the funding agencies: Agence Nationale de la Recherche (contract ANR-15-CE31-0020), Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), France; 'Helmholtz Alliance for Astroparticle Physics' funded by the Initiative and Networking Fund of the Helmholtz Association, Germany; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), Italy; Agence de l'Oriental and CNRST, Morocco; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; National Authority for Scientific Research (ANCS), Romania; Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain.
Published: 2018
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24. Pulse-Plating of Mn-Cu-ZnO for Supercapacitors: A Study Based on Soft X-ray Fluorescence and Absorption Microspectroscopy

Author: Benedetto Bozzini, Ivonne Sgura, Majid Kazemian Abyaneh, David Jezersěk, Claudio Mele, Alessandra Gianoncelli, Maya Kiskinova, Bozzini, Benedetto, Gianoncelli, A., Mele, Claudio, Abyaneh, M. K., Djezeršek, D. Jezeršek, Kiskinova, M., Alessandra, Gianoncelli, Majid Kazemian, Abyaneh, David, Jezersek, Sgura, Ivonne, and Maya, Kiskinova
Subjects: Materials science, Analytical chemistry, Electrochemistry, Catalysis, law.invention, pulse plating, symbols.namesake, soft X-rays, law, Microcell, X-ray microscopy, supercapacitor, Absorption (electromagnetic radiation), Supercapacitor, business.industry, Doping, Fluorescence, Synchrotron, soft X-ray, ZnO, symbols, Optoelectronics, business, Raman spectroscopy
Abstract: This paper reports on the electrodeposition of Mn–Cu–ZnO for hybrid supercapacitors. This material exhibits a dual structure consisting of Mn-rich highly active, but poorly electronically conducting, grains, which are locked by a Cu-rich highly conductive network that also possesses some degree of charge-storage capacity. This work focuses on morphological, compositional, and chemical-state distributions with submicrometer lateral resolution. This information, which is crucial because doping distribution controls supercapacitor performance, has been obtained by combining electrochemical and in situ Raman measurements with synchrotron-based X-ray fluorescence and absorption microspectroscopy. Using a microfabricated thin-layer three-electrode microcell, we followed the morphochemical changes at different electrodeposition stages and found that pulse-plating allows the growth of Mn- and Cu-doped ZnO as self-organized structures with a consistent spatially stable composition distribution.
Published: 2014
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25. In-Office Bleaching During Orthodontic Treatment

Author: A.G. Devito-Moraes, Hélio Dutra, Ricardo Sgura, M. N Gomes, and Alexandre Morais
Subjects: Orthodontics, Enamel paint, Dentition, business.industry, Office visits, Dentistry, 030206 dentistry, stomatognathic diseases, 03 medical and health sciences, Orthodontic brackets, 0302 clinical medicine, stomatognathic system, Treatment interruption, visual_art, visual_art.visual_art_medium, Medicine, In patient, 030212 general & internal medicine, business, General Dentistry
Abstract: Objective To demonstrate that it is possible to pursue teeth whitening treatment protocols during orthodontic treatment with no esthetic loss. Clinical Considerations Many patients undergoing orthodontic treatment desire to have a straight and well aligned dentition, but also whiter teeth. For many years, it was believed that carrying out a whitening treatment with positioned orthodontic brackets in place would result in localized spots on the enamel labial surfaces of teeth. However, a deeper understanding of the bleaching process suggests that the oxidation caused by products, which results from hydrogen peroxide decomposition, are able to diffuse peripherally into the tooth structure and reach even that under the cemented brackets. Two in-office-bleaching treatments were performed in patients using orthodontic fixed braces in two or three 40-minute sessions using a 35% hydrogen peroxide. Conclusion In-office bleaching is possible and effective, even with orthodontic brackets in position. The teeth were successfully bleached despite the presence of brackets. All biological criteria have been fulfilled satisfying patients' expectations of aligned and whitened teeth in less time than if treatments had been performed separately, with satisfactory results and no esthetic loss. CLINICAL SIGNIFICANCE The whitening of teeth is possible during orthodontic treatment with fixed braces without any esthetic loss. The in-office bleaching treatment with brackets in position also may act as a motivation factor, preventing patient withdrawal or treatment interruption. Therefore, at the end of the orthodontic treatment, the patient is able to display an aligned, functional and whitened smile. (J Esthet Restor Dent 29:83–92, 2017)
Published: 2016
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26. A method to stabilise the performance of negatively fed KM3NeT photomultipliers

Author: M. Circella, C. D'Amato, Andrea Biagioni, G. Kieft, G. Pellegrini, Antonio Capone, S. Adrián-Martínez, P. Timmer, J. Schmelling, Piero Vicini, Maurizio Spurio, Rosanna Cocimano, Antonio D'Onofrio, A.J. Heijboer, J.A. Martínez-Mora, Fabrizio Ameli, G. Pühlhofer, M. de Jong, F. Terrasi, F. Versari, Bruny Baret, M. Ageron, M. Morganti, D. Lo Presti, Jörn Wilms, Els Koffeman, Michel André, C. Perrina, F. Di Capua, S. Eichie, P. Coyle, Giacomo Cuttone, B. Bouhadef, Paolo Fermani, Jürgen Brunner, E. Barbarito, Raffaele Buompane, V. Giordano, Mario Musumeci, A. Cosquer, R. Bruijn, G.E. Păvălaş, G. Ferrara, D. Stransky, A. Trovato, P. Migliozzi, A.M. van den Berg, V. Van Elewyck, A. Martini, A. Liolios, L. Quinn, I. Di Palma, G. C. Barbarino, Apostolos Tsirigotis, M. Durocher, Silvio Cherubini, I. Olcina, G. Cacopardo, Cristiano Bozza, T. Avgitas, M. M. Pfützner, N. Randazzo, E. Drakopoulou, Fabio Marzaioli, Herbert Löhner, S. Galatà, S. Bourret, S. Henry, G. E. Poma, K. Pikounis, M. Saldaña, Francesco Simeone, Alessandro Lonardo, F. Raffaelli, B. Vallage, A. Marinelli, M. Sedita, A. Sánchez Losa, L. Caillat, A. Enzenhöfer, Oleg Kalekin, Fabio Pratolongo, A. D'Amico, Antonios Leisos, C. Boutonnet, M. Gebyehu, Lucio Gialanella, J.D. Zornoza, Yahya Tayalati, D. Kießling, M.C. Bouwhuis, Sara Pulvirenti, Carmelo Pellegrino, F. Garufi, M. Volkert, R. Mele, Silvia Celli, Simona Maria Stellacci, S. Loucatos, T. Pradier, A. Coleiro, L. Classen, R. Bormuth, Vitaliano Chiarella, P. Piattelli, V. van Beveren, Matthias Kadler, L. K. Resvanis, V. Sciacca, M. Anghinolfi, Giulia Illuminati, D. van Eijk, S. Theraube, J. C. Vermeulen, K. Zachariadou, Domenico Santonocito, C. W. James, Patrick Lamare, Sotirios Harissopulos, H. van Haren, E. Migneco, L Chiarelli, F. Schimmel, G. Frascadore, B. Spisso, M. Cordelli, C. D. Llorens Alvarez, Valeria Sipala, T. Michael, Thomas Eberl, M. Lotze, M. Taiuti, A. Rovelli, Abdelilah Moussa, Paolo Musico, Michael Kreter, Carlos Maximiliano Mollo, L. Trasatti, F. Giacomini, M. Ardid, M. Furini, C. Olivetto, L.W. Wiggers, M. Hevinga, Nicolo' Beverini, H. Peek, C. Hugon, S. Colonges, D. Calvo, P. Jansweijer, Gisela Anton, S.F. Biagi, M. Billault, C. De Sio, A. Albert, E. Buis, C. Tönnis, Diego Real, C. Racca, Antoine Kouchner, Corinne Donzaud, Paolo Sapienza, P.M. Kooijman, A. Paolucci, A. Papaikonomou, E. Berbee, V. Popa, G. De Bonis, I. Salvadori, Robert Lahmann, J. Reubelt, T. Heid, Georgios Stavropoulos, Sebastiano Aiello, A. Sánchez García, Karl Mannheim, E. Tzamariudaki, M. Mongelli, I. El Bojaddaini, C. Rossi, M. Calamai, D. Drouhin, Q. Dorosti-Hasankiadeh, Steffen Hallmann, M. Bondì, E. G. Anassontzis, Damien Dornic, Jos Steijger, Riccardo Travaglini, Alexander Kappes, A. Miraglia, Salvatore Viola, E. Heine, Dominik Elsaesser, G. Bourlis, P. Keller, G. Grella, Matteo Sanguineti, G. Pancaldi, Andrea Santangelo, A. Grmek, P. Mijakowski, Kay Graf, Karel Melis, J. Barrios-Martí, Enrico Maccioni, R. Habel, M. Favaro, S. Beurthey, Nectaria A. B. Gizani, Carlo Alessandro Nicolau, M. Lindsey Clark, S. Tzamarias, C. Markou, Riccardo Papaleo, G. Riccobene, Uli Katz, A. Belias, A. Creusot, A. Orzelli, E. De Wolff, R. Gracia, G. Androulakis, Jutta Schnabel, O. Mariş, M. Jongen, Jose Busto, D. Cobas, J. Zúñiga, T. Gal, T. Seitz, C. Distefano, D. F. E. Samtleben, Daniele Vivolo, A. Margotti, S Zani, Luigi Antonio Fusco, Joao A B Coelho, M. Guerzoni, L. Caramete, T. Grégoire, Annarita Margiotta, D. Tézier, I. Sgura, Angelo Orlando, C. Champion, V. Kulikovskiy, M. Manzali, S. Cecchini, Juan José Hernández-Rey, Emanuele Leonora, Tommaso Chiarusi, R. Coniglione, J. Hofestädt, V. Bertin, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Km3NeT Collaboration, Adrián Martínez, S. Am, Ageron, M. B, Aiello, S. S, Albert, A. An, Ameli, F. W, Anassontzis, E. G. Ad, Andre, M. Al, Androulakis, G. Ab, Anghinolfi, M. T, Anton, G. G, Ardid, M. Am, Avgitas, T. C, Barbarino, G. Uai, Barbarito, E. Q, Baret, B. C, Barrios Martí, J. K, Belias, A. Ab, Berbee, E. F, Van Den Berg, A. Y, Bertin, V. B, Beurthey, S. B, Van Beveren, V. F, Beverini, N. Vaj, Biagi, S. O, Biagioni, A. W, Billault, M. B, Bondì, M. S, Bormuth, R. Fz, Bouhadef, B. V, Bourlis, G. J, Bourret, S. C, Boutonnet, C. C, Bouwhuis, M. F, Bozza, C. At, Bruijn, R. Aq, Brunner, J. B, Buis, E. Ag, Buompane, R. Uae, Busto, J. B, Cacopardo, G. O, Caillat, L. B, Calamai, M. V, Calvo, D. K, Capone, A. Wak, Caramete, L. X, Cecchini, S. R, Celli, S. Iwak, Champion, C. C, Cherubini, S. Oar, Chiarella, V. P, Chiarelli, L. Nr, Chiarusi, T. R, Circella, M. Q, Classen, L. G, Cobas, D. C, Cocimano, R. O, Coelho, J. A. B. C, Coleiro, A. C, Colonges, S. C, Coniglione, R. O, Cordelli, M. P, Cosquer, A. B, Coyle, P. B, Creusot, A. C, Cuttone, G. O, D'Amato, C. O, D'Amico, A. F, D'Onofrio, A. Uae, De Bonis, G. W, De Sio, C. At, DI CAPUA, Francesco, Di Palma, I. Wak, Distefano, C. O, Donzaud, C. C, Dornic, D. B, Dorosti Hasankiadeh, Q. Y, Drakopoulou, E. Ab, Drouhin, D. An, Durocher, M. Io, Eberl, T. G, Eichie, S. Gh, Van Eijk, D. F, El Bojaddaini, I. Ao, Elsaesser, D. Au, Enzenhöfer, A. B, Favaro, M. Nr, Fermani, P. W, Ferrara, G. Oar, Frascadore, G. O, Furini, M. R, Fusco, L. A. Rah, Gal, T. G, Galatà, S. C, Garufi, F. Uai, Gay, P. Cm, Gebyehu, M. F, Giacomini, F. Nr, Gialanella, L. Uae, Giordano, V. S, Gizani, N. J, Gracia, R. C, Graf, K. G, Grégoire, T. C, Grella, G. At, Grmek, A. O, Guerzoni, M. R, Habel, R. P, Hallmann, S. G, Van Haren, H. Ac, Harissopulos, S. Ab, Heid, T. G, Heijboer, A. F, Heine, E. F, Henry, S. B, Hernández Rey, J. J. K, Hevinga, M. Y, Hofestädt, J. G, Hugon, C. M. F. T, Illuminati, G. K, James, C. W. G, Jansweijer, P. F, Jongen, M. F, De Jong, M. F, Kadler, M. Au, Kalekin, O. G, Kappes, A. G, Katz, U. F. G, Keller, P. B, Kieft, G. F, Kießling, D. G, Koffeman, E. N. F, Kooijman, P. Aqav, Kouchner, A. C, Kreter, M. Au, Kulikovskiy, V. B, Lahmann, R. G, Lamare, P. B, Leisos, A. J, Leonora, E. S, Clark, M. L. C, Liolios, A. D, Alvarez, C. D. L. Am, Lo Presti, D. S, Löhner, H. Y, Lonardo, A. W, Lotze, M. K, Loucatos, S. C, Maccioni, E. Vaj, Mannheim, K. Au, Manzali, M. Nr, Margiotta, A. Rah, Margotti, A. R, Marinelli, A. Vaj, Mariš, O. X, Markou, C. Ab, Martínez Mora, J. A. Am, Martini, A. P, Marzaioli, F. Uae, Mele, R. Uai, Melis, K. W. F, Michael, T. F, Migliozzi, P. U, Migneco, E. O, Mijakowski, P. Aa, Miraglia, A. O, Mollo, C. M. U, Mongelli, M. Q, Morganti, M. Av, Moussa, A. Ao, Musico, P. T, Musumeci, M. O, Nicolau, C. A. W, Olcina, I. K, Olivetto, C. C, Orlando, A. O, Orzelli, A. T, Pancaldi, G. R, Paolucci, A. R, Papaikonomou, A. J, Papaleo, R. O, Pǎvǎlaš, G. E. X, Peek, H. F, Pellegrini, G. R, Pellegrino, C. Rah, Perrina, C. Wak, Pfutzner, M. F, Piattelli, P. O, Pikounis, K. Ab, Poma, G. E. Oar, Popa, V. X, Pradier, T. L, Pratolongo, F. T, Pühlhofer, G. E, Pulvirenti, S. O, Quinn, L. B, Racca, C. An, Raffaelli, F. V, Randazzo, N. S, Real, D. K, Resvanis, L. Ad, Reubelt, J. G, Riccobene, G. O, Rossi, C. T, Rovelli, A. O, Saldaña, M. Am, Salvadori, I. B, Samtleben, D. F. E. Fz, Sánchez García, A. K, Sánchez Losa, A. Q, Sanguineti, M. T, Santangelo, A. E, Santonocito, D. O, Sapienza, P. O, Schimmel, F. F, Schmelling, J. F, Schnabel, J. G, Sciacca, V. O, Sedita, M. O, Seitz, T. G, Sgura, I. Q, Simeone, F. W, Sipala, V. S, Spisso, B. Uat, Spurio, M. Rah, Stavropoulos, G. Ab, Steijger, J. F, Stellacci, S. M. At, Stransky, D. G, Taiuti, M. Ta, Tayalati, Y. Aoap, Terrasi, F. Uae, Tézier, D. B, Theraube, S. B, Timmer, P. F, Tönnis, C. K, Trasatti, L. P, Travaglini, R. R, Trovato, A. O, Tsirigotis, A. J, Tzamarias, S. D, Tzamariudaki, E. Ab, Vallage, B. C, Van Elewyck, V. C, Vermeulen, J. F, Versari, F. Rah, Vicini, P. W, Viola, S. O, Vivolo, D. Uai, Volkert, M. G, Wiggers, L. F, Wilms, J. H, De Wolf, E. Faq, Zachariadou, K. Af, Zani, S. Nr, Zornoza, J. D. K, Zúñiga, J. K., Adrián-Martínez, S., Ageron, M., Aiello, S., Albert, A., Ameli, F., Anassontzis, E.G., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Martí, J., Belias, A., Berbee, E., Van Den Berg, A., Bertin, V., Beurthey, S., Van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bondì, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Buompane, R., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Cherubini, S., Chiarella, V., Chiarelli, L., Chiarusi, T., Circella, M., Classen, L., Cobas, D., Cocimano, R., Coelho, J.A.B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., D'Onofrio, A., De Bonis, G., De Sio, C., Di Capua, F., Di Palma, I., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Durocher, M., Eberl, T., Eichie, S., Van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhöfer, A., Favaro, M., Fermani, P., Ferrara, G., Frascadore, G., Furini, M., Fusco, L.A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giacomini, F., Gialanella, L., Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Grmek, A., Guerzoni, M., Habel, R., Hallmann, S., Van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J.J., Hevinga, M., Hofestädt, J., Hugon, C.M.F., Illuminati, G., James, C.W., Jansweijer, P., Jongen, M., De Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U.F., Keller, P., Kieft, G., Kießling, D., Koffeman, E.N., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamare, P., Leisos, A., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C.D. Lloren, Lo Presti, D., Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Manzali, M., Margiotta, A., Margotti, A., Marinelli, A., Mariš, O., Markou, C., Martínez-Mora, J.A., Martini, A., Marzaioli, F., Mele, R., Melis, K.W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C.M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Nicolau, C.A., Olcina, I., Olivetto, C., Orlando, A., Orzelli, A., Pancaldi, G., Paolucci, A., Papaikonomou, A., Papaleo, R., Pǎvǎlaš, G.E., Peek, H., Pellegrini, G., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Poma, G.E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D.F.E., Sánchez García, A., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S.M., Stransky, D., Taiuti, M., Tayalati, Y., Terrasi, F., Tézier, D., Theraube, S., Timmer, P., Tönnis, C., Trasatti, L., Travaglini, R., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Versari, F., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Wiggers, L., Wilms, J., De Wolf, E., Zachariadou, K., Zani, S., Zornoza, J.D., Zúñiga, J., Adrian-Martinez, S, Ageron, M, Aiello, S, Albert, A, Ameli, F, Anassontzis, Eg, Andre, M, Androulakis, G, Anghinolfi, M, Anton, G, Ardid, M, Avgitas, T, Barbarino, G, Barbarito, E, Baret, B, Barrios-Marti, J, Belias, A, Berbee, E, van den Berg, A, Bertin, V, Beurthey, S, van Beveren, V, Beverini, N, Biagi, S, Biagioni, A, Billault, M, Bondi, M, Bormuth, R, Bouhadef, B, Bourlis, G, Bourret, S, Boutonnet, C, Bouwhuis, M, Bozza, C, Bruijn, R, Brunner, J, Buis, E, Buompane, R, Busto, J, Cacopardo, G, Caillat, L, Calamai, M, Calvo, D, Capone, A, Caramete, L, Cecchini, S, Celli, S, Champion, C, Cherubini, S, Chiarella, V, Chiarelli, L, Chiarusi, T, Circella, M, Classen, L, Cobas, D, Cocimano, R, Coelho, Jab, Coleiro, A, Colonges, S, Coniglione, R, Cordelli, M, Cosquer, A, Coyle, P, Creusot, A, Cuttone, G, D'Amato, C, D'Amico, A, D'Onofrio, A, De Bonis, G, De Sio, C, Di Capua, F, Di Palma, I, Distefano, C, Donzaud, C, Dornic, D, Dorosti-Hasankiadeh, Q, Drakopoulou, E, Drouhin, D, Durocher, M, Eberl, T, Eichie, S, van Eijk, D, El Bojaddaini, I, Elsaesser, D, Enzenhofer, A, Favaro, M, Fermani, P, Ferrara, G, Frascadore, G, Furini, M, Fusco, La, Gal, T, Galata, S, Garufi, F, Gay, P, Gebyehu, M, Giacomini, F, Gialanella, L, Giordano, V, Gizani, N, Gracia, R, Graf, K, Gregoire, T, Grella, G, Grmek, A, Guerzoni, M, Habel, R, Hallmann, S, van Haren, H, Harissopulos, S, Heid, T, Heijboer, A, Heine, E, Henry, S, Hernandez-Rey, Jj, Hevinga, M, Hofestadt, J, Hugon, Cmf, Illuminati, G, James, Cw, Jansweijer, P, Jongen, M, de Jong, M, Kadler, M, Kalekin, O, Kappes, A, Katz, Uf, Keller, P, Kieft, G, Kiessling, D, Koffeman, En, Kooijman, P, Kouchner, A, Kreter, M, Kulikovskiy, V, Lahmann, R, Lamare, P, Leisos, A, Leonora, Je, Clark, Ml, Liolios, A, Alvarez, Cdl, Lo Presti, D, Lohner, H, Lonardo, A, Lotze, M, Loucatos, S, Maccioni, E, Mannheim, K, Manzali, M, Margiotta, A, Margotti, A, Marinelli, A, Maris, O, Markou, C, Martinez-Mora, Ja, Martini, A, Marzaioli, F, Mele, R, Melis, Kw, Michael, T, Migliozzi, P, Migneco, E, Mijakowski, P, Miraglia, A, Mollo, Cm, Mongelli, M, Morganti, M, Moussa, A, Musico, P, Musumeci, M, Nicolau, Ca, Olcina, I, Olivetto, C, Orlando, A, Orzelli, A, Pancaldi, G, Paolucci, A, Papaikonomou, A, Papaleo, R, Pavalas, Ge, Peek, H, Pellegrini, G, Pellegrino, C, Perrina, C, Pfutzner, M, Piattelli, P, Pikounis, K, Poma, Ge, Popa, V, Pradier, T, Pratolongo, F, Puhlhofer, G, Pulvirenti, S, Quinn, L, Racca, C, Raffaelli, F, Randazzo, N, Real, D, Resvanis, L, Reubelt, J, Riccobene, G, Rossi, C, Rovelli, A, Saldana, M, Salvadori, I, Samtleben, Dfe, Garcia, A, Losa, A, Sanguineti, M, Santangelo, A, Santonocito, D, Sapienza, P, Schimmel, F, Schmelling, J, Schnabel, J, Sciacca, V, Sedita, M, Seitz, T, Sgura, I, Simeone, F, Sipala, V, Spisso, B, Spurio, M, Stavropoulos, G, Steijger, J, Stellacci, Sm, Stransky, D, Taiuti, M, Tayalati, Y, Terrasi, F, Tezier, D, Theraube, S, Timmer, P, Tonnis, C, Trasatti, L, Travaglini, R, Trovato, A, Tsirigotis, A, Tzamarias, S, Tzamariudaki, E, Vallage, B, Van Elewyck, V, Vermeulen, J, Versari, F, Vicini, P, Viola, S, Vivolo, D, Volkert, M, Wiggers, L, Wilms, J, de Wolf, E, Zachariadou, K, Zani, S, Zornoza, Jd, Zuniga, J, Centre Tecnològic de Vilanova i la Geltrú, Universitat Politècnica de Catalunya. LAB - Laboratori d'Aplicacions Bioacústiques, Research unit Astroparticle Physics, Adrián Martínez, S., Anassontzis, E. G., Barrios Martí, J., Coelho, J. A. B., D'Onofrio, Antonio, Dorosti Hasankiadeh, Q., Fusco, L. A., Gialanella, Lucio, Hernández Rey, J. J., Hugon, C. M. F., James, C. W., Katz, U. F., Koffeman, E. N., Alvarez, C. D. Lloren, Martínez Mora, J. A., Marzaioli, Fabio, Melis, K. W., Mollo, C. M., Nicolau, C. A., Pǎvǎlaš, G. E., Poma, G. E., Samtleben, D. F. E., Stellacci, S. M., Terrasi, Filippo, and Zornoza, J. D.
Subjects: PROTOTYPE, Physics::Instrumentation and Detectors, photomultiplier, coating, KM3NeT, neutrino telescope, Instrument optimization, Large detector systems for particle and astroparticle physics, Neutrino detectors, Photon detectors for UV, visible and IR photons (gas) (gas-photocathodes, solid-photocathodes), Instrumentation, Mathematical Physics, 01 natural sciences, Neutrino detector, 010303 astronomy & astrophysics, Photon detectors for UV, Physics, OPT - Optics, TS - Technical Sciences, [SDU.ASTR]Sciences of the Universe [physics]/Astrophysics [astro-ph], Instrument optimisation, Astrophysics::Instrumentation and Methods for Astrophysics, High voltage, Optoelectronics, Nano Technology, Neutrino, Photomultiplier, visible and IR photons (gas) (gas-photocathodes, Context (language use), Photon detectors for UV, visible and IR photons (gas) (gas-photocathodes, solid-photocathode, Partícules (Física nuclear), Photocathode, NO, Optics, 0103 physical sciences, Neutrins, 14. Life underwater, Electronics, Neutrinos, Detectors òptics, Optical detectors, Física [Àrees temàtiques de la UPC], 010308 nuclear & particles physics, business.industry, Neutrino astrophysics, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], FISICA APLICADA, Large detector systems for particle and astroparticle physic, Visible and IR photons (gas) (gas-photocathodes, solid-photocathodes), solid-photocathodes), business
Abstract: [EN] The KM3NeT research infrastructure, currently under construction in the Mediterranean Sea, will host neutrino telescopes for the identification of neutrino sources in the Universe and for studies of the neutrino mass hierarchy. These telescopes will house hundreds of thousands of photomultiplier tubes that will have to be operated in a stable and reliable fashion. In this context, the stability of the dark counts has been investigated for photomultiplier tubes with negative high voltage on the photocathode and held in insulating support structures made of 3D printed nylon material. Small gaps between the rigid support structure and the photomultiplier tubes in the presence of electric fields can lead to discharges that produce dark count rates that are highly variable. A solution was found by applying the same insulating varnish as used for the high voltage bases directly to the outside of the photomultiplier tubes. This transparent conformal coating provides a convenient and inexpensive method of insulation., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), France; The General Secretariat of Research and Technology (GSRT), Greece; Istituto Nazionale di Fisica Nucleare (INFN), Ministero dell'Istruzione, dell'Universita e della Ricerca (MIUR), Italy; Agence de l'Oriental and CNRST, Morocco; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandse organisatie voorWetenschappelijk Onderzoek (NWO), the Netherlands; National Authority for Scientific Research (ANCS), Romania; Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain.
Published: 2016
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27. Correction to: Structural modeling of a novel TERC variant in a patient with aplastic anemia and short telomeres

Author: Anna Paola Iori, Emanuele Agolini, L. Quattrocchi, Silvia Majore, A. Sgura, F. Berardinelli, Antonio Novelli, Giulia Pascolini, Paola Grammatico, Emanuele Bellacchio, and Martina Rinelli
Subjects: medicine.medical_specialty, Pediatrics, Hematology, business.industry, MEDLINE, Mistake, General Medicine, medicine.disease, Telomere, Internal medicine, medicine, Aplastic anemia, business
Abstract: The original version of this article contained a mistake in the affiliation of E. Bellacchio. Correct affiliation is presented here.
Published: 2018

28. mFISH analysis of irradiated human fibroblasts: a comparison among radiations with different quality in the low-dose range: Figure 1

Author: Antonio Antoccia, Roberto Cherubini, Francesco Berardinelli, D. Nieri, S. Gerardi, Antonella Sgura, V. De Nadal, and Caterina Tanzarella
Subjects: Range (particle radiation), Radiation, Radiobiology, Materials science, Radiological and Ultrasound Technology, business.industry, Radiation quality, Energy transfer, Low dose, Radiochemistry, Public Health, Environmental and Occupational Health, General Medicine, Ion, Quality (physics), Radiology, Nuclear Medicine and imaging, Irradiation, Nuclear medicine, business
Abstract: The present investigation aimed to characterise the shape of dose-response curve and determining the frequency distribution of various aberration types as a function of dose and radiation quality in AG01522 primary human fibroblasts in the 0.1- to 1-Gy dose range. For this purpose, the cells were irradiated with 7.7 and 28.5 keV µm(-1) low-energy protons, 62 keV µm(-1 4)He(2+) ions (LNL Radiobiology facility) or X rays and samples collected for 24-colour mFISH analysis. X rays and 7.7 keV µm(-1) protons displayed a quadratic dose-response curve solely for total and simple exchanges, whereas for high-linear energy transfer radiations, a linear dose-response curve was observed for all the aberration categories, with the exception of complex exchanges.
Published: 2015
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29. Acute hemodynamic effects of intravenous adenosine in patients with associated pulmonary arterial hypertension: Comparison with intravenous epoprostenol

Author: Giuseppe Boriani, Daniel Monopoli, Francesca Coppi, Rosario Rossi, and F Sgura
Subjects: Pulmonary and Respiratory Medicine, Adult, Male, medicine.medical_specialty, Adenosine, Hypertension, Pulmonary, Vasodilator Agents, Cardiac index, Hemodynamics, Vasodilation, Blood Pressure, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, medicine.artery, Internal medicine, Heart rate, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Associated Pulmonary Arterial Hypertension, Antihypertensive Agents, Aged, Retrospective Studies, business.industry, Biochemistry (medical), Epoprostenol, Pulmonary arterial hypertension, Pulmonary circulation, Pulmonary vasodilation, Right heart catheterization, Middle Aged, medicine.anatomical_structure, Anesthesia, Pulmonary artery, Cardiology, Vascular resistance, Administration, Intravenous, Female, business, medicine.drug
Abstract: Exogenous intravenous (IV) adenosine and epoprostenol are effective vasodilator agents, causing a substantial reduction in pulmonary vascular resistance in patients affected by idiopathic pulmonary arteriolar hypertension (PAH). Their action, in patients with PAH associated with other pathological conditions, is not well defined. In the present paper the authors retrospectively analyzed the acute hemodynamic effects of intravenous adenosine and epoprostenol in 30 consecutive patients (mean age: 58 ± 15 years; 21 females, and 9 males) affected by PAH associated with other pathological conditions, as determined by changes from baseline in systemic and pulmonary hemodynamic parameters. Acute IV administration of adenosine decreased pulmonary vascular resistance index (PVRI) by 3 Wood U/m2 (- 20%) compared to baseline (p = 0.02). We noted a slight, not significant, decrease in mean pulmonary artery pressure (mPAP) of 4 mmHg. Cardiac index (CI) increased by 0.5 L/min/m2 (15% increase respect to baseline; p = 0.03). The heart rate and mean systemic blood pressure (BP) did not change significantly. Acute IV administration of epoprostenol decreased PVRI by 6 mmHg (- 40%) respect to baseline (p Our results indicates that, in patients with PAH associated with other pathological conditions, adenosine is predominantly a positive inotropic agent; and epoprostenol a potent vasodilator of both pulmonary and systemic vessels, and a strong positive inotropic agent.
Published: 2018

30. The prototype detection unit of the KM3NeT detector: KM3NeT Collaboration

Author: S. Adrián-Martínez, M. Ageron, F. Aharonian, S. Aiello, A. Albert, F. Ameli, E. G. Anassontzis, G. C. Androulakis, M. Anghinolfi, G. Anton, S. Anvar, M. Ardid, T. Avgitas, K. Balasi, H. Band, G. Barbarino, E. Barbarito, F. Barbato, B. Baret, S. Baron, J. Barrios, A. Belias, E. Berbee, A. M. van den Berg, A. Berkien, V. Bertin, S. Beurthey, V. van Beveren, N. Beverini, S. Biagi, A. Biagioni, S. Bianucci, M. Billault, A. Birbas, H. Boer Rookhuizen, R. Bormuth, V. Bouché, B. Bouhadef, G. Bourlis, C. Boutonnet, M. Bouwhuis, C. Bozza, R. Bruijn, J. Brunner, G. Cacopardo, L. Caillat, M. Calamai, D. Calvo, A. Capone, L. Caramete, F. Caruso, S. Cecchini, A. Ceres, R. Cereseto, C. Champion, F. Château, T. Chiarusi, B. Christopoulou, M. Circella, L. Classen, R. Cocimano, A. Coleiro, S. Colonges, R. Coniglione, A. Cosquer, M. Costa, P. Coyle, A. Creusot, G. Cuttone, C. D’Amato, A. D’Amico, G. De Bonis, G. De Rosa, N. Deniskina, J.-J. Destelle, C. Distefano, F. Di Capua, C. Donzaud, D. Dornic, Q. Dorosti-Hasankiadeh, E. Drakopoulou, D. Drouhin, L. Drury, D. Durand, T. Eberl, D. Elsaesser, A. Enzenhöfer, P. Fermani, L. A. Fusco, D. Gajanana, T. Gal, S. Galatà, F. Garufi, M. Gebyehu, V. Giordano, N. Gizani, R. Gracia Ruiz, K. Graf, R. Grasso, G. Grella, A. Grmek, R. Habel, H. van Haren, T. Heid, A. Heijboer, E. Heine, S. Henry, J. J. Hernández-Rey, B. Herold, M. A. Hevinga, M. van der Hoek, J. Hofestädt, J. Hogenbirk, C. Hugon, J. Hößl, M. Imbesi, C. W. James, P. Jansweijer, J. Jochum, M. de Jong, M. Jongen, M. Kadler, O. Kalekin, A. Kappes, E. Kappos, U. Katz, O. Kavatsyuk, P. Keller, G. Kieft, E. Koffeman, H. Kok, P. Kooijman, J. Koopstra, A. Korporaal, A. Kouchner, I. Kreykenbohm, V. Kulikovskiy, R. Lahmann, P. Lamare, G. Larosa, D. Lattuada, H. Le Provost, K. P. Leismüller, A. Leisos, D. Lenis, E. Leonora, M. Lindsey Clark, C. D. Llorens Alvarez, H. Löhner, A. Lonardo, S. Loucatos, F. Louis, E. Maccioni, K. Mannheim, K. Manolopoulos, A. Margiotta, O. Mariş, C. Markou, J. A. Martínez-Mora, A. Martini, R. Masullo, K. W. Melis, T. Michael, P. Migliozzi, E. Migneco, A. Miraglia, C. M. Mollo, M. Mongelli, M. Morganti, S. Mos, Y. Moudden, P. Musico, M. Musumeci, C. Nicolaou, C. A. Nicolau, A. Orlando, A. Orzelli, A. Papaikonomou, R. Papaleo, G. E. Păvălaş, H. Peek, C. Pellegrino, M. G. Pellegriti, C. Perrina, P. Piattelli, K. Pikounis, V. Popa, Th. Pradier, M. Priede, G. Pühlhofer, S. Pulvirenti, C. Racca, F. Raffaelli, N. Randazzo, P. A. Rapidis, P. Razis, D. Real, L. Resvanis, J. Reubelt, G. Riccobene, A. Rovelli, M. Saldaña, D. F. E. Samtleben, M. Sanguineti, A. Santangelo, P. Sapienza, J. Schmelling, J. Schnabel, V. Sciacca, M. Sedita, T. Seitz, I. Sgura, F. Simeone, V. Sipala, A. Spitaleri, M. Spurio, G. Stavropoulos, J. Steijger, T. Stolarczyk, D. Stransky, M. Taiuti, G. Terreni, D. Tézier, S. Théraube, L. F. Thompson, P. Timmer, L. Trasatti, A. Trovato, M. Tselengidou, A. Tsirigotis, S. Tzamarias, E. Tzamariudaki, B. Vallage, V. Van Elewyck, J. Vermeulen, P. Vernin, P. Vicini, S. Viola, D. Vivolo, P. Werneke, L. Wiggers, J. Wilms, E. de Wolf, R. H. L. van Wooning, E. Zonca, J. D. Zornoza, J. Zúñiga, A. Zwart, Adrian-Martinez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Androulakis, G. C., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Avgitas, T., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Barrios, J., Belias, A., Berbee, E., van den Berg, A. M., Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Birbas, A., Boer Rookhuizen, H., Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Coleiro, A., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Di Capua, F., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Elsaesser, D., Enzenhofer, A., Fermani, P., Fusco, L. A., Gajanana, D., Gal, T., Galata, S., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Gracia Ruiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestadt, J., Hogenbirk, J., Hugon, C., Hossl, J., Imbesi, M., James, C. W., Jansweijer, P., Jochum, J., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Le Provost, H., Leismuller, K. P., Leisos, A., Lenis, D., Leonora, E., Lindsey Clark, M., Llorens Alvarez, C. D., Lohner, H., Lonardo, A., Loucatos, S., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J. A., Martini, A., Masullo, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, T., Priede, M., Puhlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Saldana, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L. F., Timmer, P., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Vicini, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Zonca, E., Zornoza, J. D., Zuniga, J., Zwart, A., Adrián Martínez, S., Biagi, S, Bouché, V., Château, F., D’Amato, C., D’Amico, A., Destelle, J. J., Dorosti Hasankiadeh, Q., Enzenhöfer, A., Fusco, LUIGI ANTONIO, Galatà, S., Hernández Rey, J. J., Hofestädt, J., Hößl, J., Leismüller, K. P., Löhner, H., Margiotta, Annarita, Mariş, O., Martínez Mora, J. A., Păvălaş, G. E., Pellegrino, Carmelo, Pradier, T. h., Pühlhofer, G., Saldaña, M., Spurio, Maurizio, Tézier, D., Théraube, S., and Zúñiga, J.
Subjects: Physics, Photomultiplier, Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, 010308 nuclear & particles physics, business.industry, Detector, Monte Carlo method, 01 natural sciences, Signal, Optics, KM3NeT, 0103 physical sciences, Calibration, 14. Life underwater, Neutrino, 010306 general physics, business, Engineering (miscellaneous), Cherenkov radiation
Abstract: A prototype detection unit of the KM3NeT deep-sea neutrino telescope has been installed at 3500m depth 80 km offshore the Italian coast. KM3NeT in its final configuration will contain several hundreds of detection units. Each detection unit is a mechanical structure anchored to the sea floor, held vertical by a submerged buoy and supporting optical modules for the detection of Cherenkov light emitted by charged secondary particles emerging from neutrino interactions. This prototype string implements three optical modules with 31 photomultiplier tubes each. These optical modules were developed by the KM3NeT Collaboration to enhance the detection capability of neutrino interactions. The prototype detection unit was operated since its deployment in May 2014 until its decommissioning in July 2015. Reconstruction of the particle trajectories from the data requires a nanosecond accuracy in the time calibration. A procedure for relative time calibration of the photomultiplier tubes contained in each optical module is described. This procedure is based on the measured coincidences produced in the sea by the $$^{40}$$40K background light and can easily be expanded to a detector with several thousands of optical modules. The time offsets between the different optical modules are obtained using LED nanobeacons mounted inside them. A set of data corresponding to 600 h of livetime was analysed. The results show good agreement with Monte Carlo simulations of the expected optical background and the signal from atmospheric muons. An almost background-free sample of muons was selected by filtering the time correlated signals on all the three optical modules. The zenith angle of the selected muons was reconstructed with a precision of about 3$$^circ $$∘.
Published: 2016

31. Long-term optical background measurements in the Capo Passero deep-sea site

Author: Daniele Vivolo, Tommaso Chiarusi, I. Sgura, Angelo Orlando, M. Circella, R. Coniglione, Carmelo Pellegrino, F. Garufi, A. Trovato, G. Cacopardo, M. Anghinolfi, A. Martini, G. C. Barbarino, Carlo Alessandro Nicolau, A. Gmerk, Cristiano Bozza, Fabio Longhitano, V. Flaminio, A. Spitaleri, M. Taiuti, M. Mongelli, Carlos Maximiliano Mollo, Rosanna Cocimano, C. Calì, Francesco Caruso, Matteo Sanguineti, C. Perrina, E. Migneco, E. Barbarito, V. D'Amato, G. Riccobene, F. Raffaelli, Paolo Sapienza, M. G. Pellegriti, P. Migliozzi, G. Debonis, Enrico Maccioni, F. C. T. Barbato, S. Biagi, Gabriele Giovanetti, Piero Vicini, Giuseppina Larosa, Francesco Simeone, P. Piattelli, Fabrizio Ameli, Valeria Sipala, C. Distefano, Luigi Antonio Fusco, M. J. Costa, Paolo Fermani, C. Pugliatti, C. D'Amato, V. De Luca, C. Hugon, F. Speziale, Maurizio Spurio, Sebastiano Aiello, Alessandro Lonardo, M. Imbesi, A. Rovelli, Sara Pulvirenti, Paolo Musico, Rosaria Grasso, L. Trasatti, M. Calamai, D. Lo Presti, G. Grella, B. Bouhadef, Nicolo' Beverini, A. Miraglia, Cynthia Ventura, D. Lattuada, Emanuele Leonora, Salvatore Viola, G. De Rosa, N. Deniskina, A. Ceres, R. Masullo, Riccardo Papaleo, Annarita Margiotta, V. Kulikovsky, V. Giordano, Mario Musumeci, N. Randazzo, A. D'Amico, P. Litrico, M. Morganti, Giacomo Cuttone, Alessia Capone, G. Terreni, Kalekin O., Real D., Finley C., Graf K., Sandstrom P., Williams D., Kelley J., Hulth P.O., Walck C., Ahlers M., Belias A., Hultqvist K., Zornoza J.D., M., Pellegriti, S., Aiello, F., Ameli, M., Anghinolfi, Barbarino, Giancarlo, E. h., Barbarito, Barbato, FELICIA CARLA TIZIANA, N. j., Beverini, S. l., Biagi, B., Bouhadef, C., Bozza, G., Cacopardo, M. j., Calamai, C., Cal, A. n., Capone, F., Caruso, A., Cere, T., Chiarusi, M., Circella, R., Cocimano, R., Coniglione, M., Costa, G., Cuttone, C., D'Amato, V., D'Amato, A., D'Amico, G., Deboni, V. D., Luca, Deniskina, Natalia, DE ROSA, Gianfranca, C., Distefano, P., Fermani, V. j., Flaminio, L. l., Fusco, Garufi, Fabio, V., Giordano, G., Giovanetti, A., Gmerk, R., Grasso, G., Grella, C. o., Hugon, M., Imbesi, V. o., Kulikovsky, G., Larosa, D., Lattuada, E., Leonora, P., Litrico, A., Lonardo, F., Longhitano, D. p., Lo, E. j., Maccioni, A. l., Margiotta, A., Martini, R., Masullo, P., Migliozzi, E., Migneco, A., Miraglia, C., Mollo, M., Mongelli, M. r., Morganti, P., Musico, M., Musumeci, C., Nicolau, A., Orlando, R., Papaleo, C. l., Pellegrino, C., Perrina, P., Piattelli, C. p., Pugliatti, S., Pulvirenti, F., Raffaelli, N., Randazzo, G., Riccobene, A., Rovelli, M. o., Sanguineti, P., Sapienza, I., Sgura, F., Simeone, V., Sipala, M. l., Spurio, F., Speziale, A., Spitaleri, M. o., Taiuti, G., Terreni, L., Trasatti, A., Trovato, C., Ventura, P., Vicini, S., Viola, Vivolo, Daniele, Pellegriti, M.G, Aiello, S., Ameli, F., Anghinolfi, M., Barbarino, G., Barbarito, E., Barbato, F., Beverini, N., Biagi, S., Bouhadef, B., Bozza, C., Cacopardo, G., Calamai, M., Calì, C., Capone, A., Caruso, F., Ceres, A., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Costa, M., Cuttone, G., D'Amato, C., D'Amato, V., D'Amico, A., Debonis, G., De Luca, V., Deniskina, N., De Rosa, G., Distefano, C., Fermani, P., Flaminio, V., Fusco, L.A., Garufi, F., Giordano, V., Giovanetti, G., Gmerk, A., Grasso, R., Grella, G., Hugon, C., Imbesi, M., Kulikovsky, V., Larosa, G., Lattuada, D., Leonora, E., Litrico, P., Lonardo, A., Longhitano, F., Lo Presti, D., Maccioni, E., Margiotta, A., Martini, A., Masullo, R., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, C.A., Orlando, A., Papaleo, R., Pellegrino, C., Perrina, C., Piattelli, P., Pugliatti, C., Pulvirenti, S., Raffaelli, F., Randazzo, N., Riccobene, G., Rovelli, A., Sanguineti, M., Sapienza, P., Sgura, I., Simeone, F., Sipala, V., Spurio, M., Speziale, F., Spitaleri, A., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Ventura, C., Vicini, P., Viola, S., Vivolo, D., Pellegriti, M. G., Cali, C., Fusco, L. A., and Nicolau, C. A.
Subjects: Baseline values, Physics, marine infrastructure, business.industry, Neutrino astrophysics, neutrino physics, underwater telescopes, marine infrastructures, neutrino physic, underwater telescope, Atmospheric sciences, Deep sea, Term (time), Physics and Astronomy (all), Optics, marine infrastructures, Neutrino astrophysics, neutrino physics, underwater telescopes, Light emission, business, Tower, Neutrino astrophysic
Abstract: In March 2013, the Nemo Phase-2 tower has been successfully installed at 100 km off-shore Capo Passero (Italy) and 3500 m depth. This 8-floor tower hosts 32 10-inch PMT's. Results from optical background measurements are presented. In particular, the analyzed rates show stable and low baseline values, compatible with the contribution of 40K light emission, with a small percentage of light bursts due to bioluminescence. All these features are a confirmation of the stability and good optical nature of the site.
Published: 2014

32. Status and first results of the NEMO Phase-2 tower

Author: C. Pugliatti, C. D'Amato, Antonio Capone, Maurizio Spurio, F. C. T. Barbato, Valeria Sipala, V. D'Amato, M. Taiuti, Carlos Maximiliano Mollo, C. Hugon, Emanuele Leonora, V. De Luca, E. Barbarito, A. Martini, B. Bouhadef, Alessandro Lonardo, V. Flaminio, Piero Vicini, N. Deniskina, Francesco Caruso, R. Coniglione, Francesco Simeone, Fabrizio Ameli, A. Miraglia, S. Biagi, Luigi Antonio Fusco, G. Cacopardo, M. J. Costa, M. Calamai, M. Anghinolfi, G. C. Barbarino, M. Mongelli, E. Migneco, Carlo Alessandro Nicolau, C. Perrina, L. Trasatti, Sebastiano Aiello, Paolo Sapienza, D. Lo Presti, M. G. Pellegriti, G. Grella, P. Litrico, C. Distefano, A. Trovato, F. Speziale, Cristiano Bozza, Carlo Ventura, R. Masullo, A. Rovelli, Riccardo Papaleo, Paolo Musico, Annarita Margiotta, I. Sgura, Fabio Longhitano, M. Imbesi, G. De Rosa, Angelo Orlando, A. Ceres, Nicolo' Beverini, Salvatore Viola, D. Lattuada, G. Debonis, Tommaso Chiarusi, Giuseppina Larosa, M. Circella, V. Kulikovsky, V. Giordano, Mario Musumeci, N. Randazzo, A. D'Amico, Carmelo Pellegrino, F. Garufi, Rosanna Cocimano, C. Calì, P. Migliozzi, A. Gmerk, Daniele Vivolo, Enrico Maccioni, F. Raffaelli, Paolo Fermani, Sara Pulvirenti, Rosaria Grasso, Gabriele Giovanetti, P. Piattelli, A. Spitaleri, Matteo Sanguineti, G. Riccobene, G. Terreni, M. Morganti, Giacomo Cuttone, Chiarusi, T., Aiello, S., Ameli, F., Anghinolfi, M., Barbarino, G., Barbarito, E., Barbato, F., Beverini, N., Biagi, S., Bouhadef, B., Bozza, C., Cacopardo, G., Calamai, M., Cali, C., Capone, A., Caruso, F., Ceres, A., Circella, M., Cocimano, R., Coniglione, R., Costa, M., Cuttone, G., D'Amato, C., D'Amato, V., D'Amico, A., Debonis, G., Luca, V. D., Deniskina, N., Rosa, G. D., Distefano, C., Fermani, P., Flaminio, V., Fusco, L. A., Garufi, F., Giordano, V., Giovanetti, G., Gmerk, A., Grasso, R., Grella, G., Hugon, C., Imbesi, M., Kulikovsky, V., Larosa, G., Lattuada, D., Leonora, E., Litrico, P., Lonardo, A., Longhitano, F., Presti, D. L., Maccioni, E., Margiotta, A., Martini, A., Masullo, R., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Papaleo, R., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pugliatti, C., Pulvirenti, S., Raffaelli, F., Randazzo, N., Riccobene, G., Rovelli, A., Sanguineti, M., Sapienza, P., Sgura, I., Simeone, F., Sipala, V., Spurio, M., Speziale, F., Spitaleri, A., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Ventura, C., Vicini, P., Viola, S., Vivolo, D., De Luca, V., De Rosa, G., Lo Presti, D., Trovato, A, T Chiarusi, S Aiello, F Ameli, M Anghinolfi, G Barbarino, E Barbarito, F Barbato, N Beverini, S Biagi, B Bouhadef, C Bozza, G Cacopardo, M Calamai, C Calì, A Capone, F Caruso, A Cere, M Circella, R Cocimano, R Coniglione, M Costa, G Cuttone, C D'Amato, V D'Amato, A D'Amico, G DeBoni, V De Luca, N Deniskina, G De Rosa, C Distefano, P Fermani, V Flaminio, L A Fusco, F Garufi, V Giordano, G Giovanetti, A Gmerk, R Grasso, G Grella, C Hugon, M Imbesi, V Kulikovsky, G Larosa, D Lattuada, E Leonora, P Litrico, A Lonardo, F Longhitano, D Lo Presti, E Maccioni, A Margiotta, A Martini, R Masullo, P Migliozzi, E Migneco, A Miraglia, C Mollo, M Mongelli, M Morganti, P Musico, M Musumeci, C A Nicolau, A Orlando, R Papaleo, C Pellegrino, M G Pellegriti, C Perrina, P Piattelli, C Pugliatti, S Pulvirenti, F Raffaelli, N Randazzo, G Riccobene, A Rovelli, M Sanguineti, P Sapienza, I Sgura, F Simeone, V Sipala, M Spurio, F Speziale, A Spitaleri, M Taiuti, G Terreni, L Trasatti, A Trovato, C Ventura, P Vicini, S Viola, D Vivolo, T., Chiarusi, S., Aiello, F., Ameli, M., Anghinolfi, Barbarino, Giancarlo, E., Barbarito, Barbato, FELICIA CARLA TIZIANA, N., Beverini, S., Biagi, B., Bouhadef, C., Bozza, G., Cacopardo, M., Calamai, C., Cal?, A., Capone, F., Caruso, A., Cere, M., Circella, R., Cocimano, R., Coniglione, M., Costa, G., Cuttone, C., D'Amato, V., D'Amato, A., D'Amico, G., Deboni, V., De Luca, Deniskina, Natalia, DE ROSA, Gianfranca, C., Distefano, P., Fermani, V., Flaminio, L. A., Fusco, Garufi, Fabio, V., Giordano, G., Giovanetti, A., Gmerk, R., Grasso, G., Grella, C., Hugon, M., Imbesi, V., Kulikovsky, G., Larosa, D., Lattuada, E., Leonora, P., Litrico, A., Lonardo, F., Longhitano, D., Lo Presti, E., Maccioni, A., Margiotta, A., Martini, R., Masullo, P., Migliozzi, E., Migneco, A., Miraglia, C., Mollo, M., Mongelli, M., Morganti, P., Musico, M., Musumeci, C. A., Nicolau, A., Orlando, R., Papaleo, C., Pellegrino, M. G., Pellegriti, C., Perrina, P., Piattelli, C., Pugliatti, S., Pulvirenti, F., Raffaelli, N., Randazzo, G., Riccobene, A., Rovelli, M., Sanguineti, P., Sapienza, I., Sgura, F., Simeone, V., Sipala, M., Spurio, F., Speziale, A., Spitaleri, M., Taiuti, G., Terreni, L., Trasatti, A., Trovato, C., Ventura, P., Vicini, S., Viola, and Vivolo, Daniele
Subjects: Phase (waves), Particle detector, Neutrino detector, Optics, Data acquisition concept, Neutrino detectors, cherenkov detectors, data acquisition concepts, neutrino detectors, neutrino detectors cherenkov detectors data acquisition concepts, WATER CHERENKOV DETECTOR, Instrumentation, Mathematical Physics, Shore station, Shore, Physics, geography, geography.geographical_feature_category, business.industry, Cherenkov detectors, Geodesy, Light emission, business, Tower, Data reduction, Cherenkov detector
Abstract: In March 2013, the NEMO Phase 2 tower has been successfully installed in the Capo Passero site, at a depth of 3500 m and 80 km off from the southern coast of Sicily. The unfurled tower is 450 m high; it is composed of 8 mechanical floors, for a total amount of 32 PMTs and various instruments for environmental measurements. The tower positioning is achieved by an acoustic system. The tower is continuously acquiring and transmitting all the measured signals to shore. Data reduction is completely performed in the Portopalo shore station by a dedicated computing facility connected to the persistent storage system at LNS, in Catania. Results from the last 9 months of acquisition will be presented. In particular, the analyzed optical rates, showing stable and low baseline values, are compatible with the contribution mainly of 40K light emission, with a small percentage of light bursts due to bioluminescence. These features reveal the optimal nature of the Capo Passero abyssal site to host a km3-sized Neutrino Telescope. © 2014 IOP Publishing Ltd and Sissa Medialab srl.
Published: 2014

33. The trigger and data acquisition for the NEMO-Phase 2 tower

Author: E. Barbarito, Francesco Simeone, Daniele Vivolo, C. Pugliatti, C. D'Amato, M. Calamai, Giuseppina Larosa, V. D'Amato, F. Speziale, C. Perrina, M. Anghinolfi, F. Garufi, V. Kulikovskiy, Maurizio Spurio, E. Migneco, Rosanna Cocimano, C. Calì, F. C. T. Barbato, A. Gmerk, Valeria Sipala, P. Migliozzi, Sebastiano Aiello, Francesco Caruso, G. Grella, M. Morganti, A. Trovato, Cristiano Bozza, Giacomo Cuttone, Alessia Capone, Carlo Alessandro Nicolau, G. Terreni, V. DeLuca, G. Debonis, M. Imbesi, Nicolo' Beverini, Cynthia Ventura, D. Lattuada, Agnese Martini, Paolo Fermani, P. Litrico, Sara Pulvirenti, Rosaria Grasso, G. DeRosa, Enrico Maccioni, A. Spitaleri, S. Biagi, M. Mongelli, Matteo Sanguineti, G. Riccobene, Tommaso Chiarusi, D. LoPresti, F. Raffaelli, R. Masullo, R. Coniglione, Gabriele Giovanetti, Riccardo Papaleo, P. Piattelli, Salvatore Viola, Alessandro Lonardo, C. Pellegrino, A. Rovelli, Paolo Musico, I. Sgura, Angelo Orlando, Giancarlo Barbarino, M. Circella, L. Trasatti, A. Ceres, C. Hugon, B. Bouhadef, A. Miraglia, V. Giordano, Mario Musumeci, N. Randazzo, N. Deniskina, A. D'Amico, Luigi Antonio Fusco, M. J. Costa, Fabio Longhitano, Annarita Margiotta, Piero Vicini, Fabrizio Ameli, Emanuele Leonora, Paolo Sapienza, M. G. Pellegriti, V. Flaminio, M. Taiuti, Carlos Maximiliano Mollo, G. Cacopardo, C. Distefano, Kalekin O., Real D., Finley C., Graf K., Sandstrom P., Williams D., Kelley J., Hulth P.O., Walck C., Ahlers M., Belias A., Hultqvist K., Zornoza J.D., C. b., Pellegrino, F., Simeone, T., Chiarusi, S., Aiello, F., Ameli, M., Anghinolfi, Barbarino, Giancarlo, E., Barbarito, Barbato, FELICIA CARLA TIZIANA, N. k., Beverini, S. b., Biagi, B., Bouhadef, C., Bozza, G., Cacopardo, M. k., Calamai, C., Cal, A. n., Capone, F., Caruso, A., Cere, M., Circella, R., Cocimano, R., Coniglione, M., Costa, G., Cuttone, C., D'Amato, V., D'Amato, A., D'Amico, G., Deboni, V., Deluca, Deniskina, Natalia, DE ROSA, Gianfranca, C., Distefano, P., Fermani, V. k., Flaminio, L. b., Fusco, Garufi, Fabio, V., Giordano, G., Giovanetti, A., Gmerk, R., Grasso, G., Grella, C. o., Hugon, M., Imbesi, V. o., Kulikovskiy, G., Larosa, D., Lattuada, E., Leonora, P., Litrico, A., Lonardo, F., Longhitano, D. p., Lopresti, E. k., Maccioni, A. b., Margiotta, A., Martini, R., Masullo, P., Migliozzi, E., Migneco, A., Miraglia, C., Mollo, M., Mongelli, M., Morganti, P., Musico, M., Musumeci, C., Nicolau, A., Orlando, R., Papaleo, M., Pellegriti, C., Perrina, P., Piattelli, C. p., Pugliatti, S., Pulvirenti, F., Raffaelli, N., Randazzo, G., Riccobene, A., Rovelli, M., Sanguineti, P., Sapienza, I., Sgura, V., Sipala, M. b., Spurio, F., Speziale, A., Spitaleri, M. o., Taiuti, G., Terreni, L., Trasatti, A., Trovato, C., Ventura, P., Vicini, S., Viola, Vivolo, Daniele, AIP Publishing, Pellegrino, C., Simeone, F., Chiarusi, T., Aiello, S., Ameli, F., Anghinolfi, M., Barbarino, G., Barbarito, E., Barbato, F., Beverini, N., Biagi, S., Bouhadef, B., Bozza, C., Cacopardo, G., Calamai, M., Cali, C., Capone, A., Caruso, F., Ceres, A., Circella, M., Cocimano, R., Coniglione, R., Costa, M., Cuttone, G., D'Amato, C., D'Amato, V., D'Amico, A., Debonis, G., Deluca, V., Deniskina, N., Derosa, G., Distefano, C., Fermani, P., Flaminio, V., Fusco, L. A., Garufi, F., Giordano, V., Giovanetti, G., Gmerk, A., Grasso, R., Grella, G., Hugon, C., Imbesi, M., Kulikovskiy, V., Larosa, G., Lattuada, D., Leonora, E., Litrico, P., Lonardo, A., Longhitano, F., Lopresti, D., Maccioni, E., Margiotta, A., Martini, A., Masullo, R., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Papaleo, R., Pellegriti, M. G., Perrina, C., Piattelli, P., Pugliatti, C., Pulvirenti, S., Raffaelli, F., Randazzo, N., Riccobene, G., Rovelli, A., Sanguineti, M., Sapienza, P., Sgura, I., Sipala, V., Spurio, M., Speziale, F., Spitaleri, A., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Ventura, C., Vicini, P., Viola, S., Vivolo, D., Calì, C., Fusco, L.A., Nicolau, C.A., and Pellegriti, M.G.
Subjects: Physics, business.industry, Bandwidth (signal processing), Neutrino telescope, Data aggregator, Physics and Astronomy (all), Data filtering, NEMO, Trigger and data acquisition system, Data acquisition, Neutrino detector, Scalability, Electronic engineering, Persistent data structure, business, Computer hardware
Abstract: In the framework of the Phase 2 of the NEMO neutrino telescope project, a tower with 32 optical modules is being operated since march 2013. A new scalable Trigger and Data Acquisition System (TriDAS) has been developed and extensively tested with the data from this tower. Adopting the all-data-to-shore concept, the NEMO TriDAS is optimized to deal with a continuous data-stream from off-shore to on-shore with a large bandwidth. The TriDAS consists of four computing layers: (i) data aggregation of isochronal hits from all optical modules; (ii) data filtering by means of concurrent trigger algorithms; (iii) composition of the filtered events into post-trigger files; (iv) persistent data storage. The TriDAS implementation is reported together with a review of dedicated on-line monitoring tools.
Published: 2014

34. The optical modules of the phase-2 of the NEMO project

Author: Aiello, S., Leonora, E., Fabrizio, Ameli, Anghinolfi, M., Anzalone, A., Barbarino, G., Barbarito, E., Barbato, F., Bersani, A., Beverini, N., Biagi, S., Bonori, Maurizio, Bouhadef, B., Bozza, C., Cacopardo, G., Capone, Antonio, Caruso, F., Ceres, A., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Cordelli, M., Costa, M., D'Amico, A., De Asmundis, R., DE BONIS, Giulia, Rosa G., De, De Vita, R., Giulia De Bonis, De Rosa, G., Distefano, C., Fermani, Paolo, Flaminio, V., Fusco, L. A., Garufi, F., Giordano, V., Giovanetti, G., Grella, G., Grimaldi, A., Habel, R., Imbesi, M., Kulikovsky, V., Lattuada, D., Leotta, G., Lonardo, A., Longhitano, F., Lo Presti, D., Maccioni, E., Margiotta, A., Marinelli, A., Martini, A., Masullo, Rocco, Maugeri, F., Migliozzi, P., Migneco, E., Minutoli, S., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, CARLO ALESSANDRO, Orlando, A., Papaleo, R., Pappalardo, V., Pellegrino, C., Perrina, Chiara, Piattelli, P., Pugliatti, C., Pulvirenti, S., Raffaelli, F., Raia, G., Randazzo, N., Riccobene, G., Rovelli, A., Russo, A., Russo, G. V., Sapienza, P., Sciliberto, D., Sedita, M., Sgura, I., Shirokov, E., Simeone, Francesco, Sipala, V., Sollima, C., Spina, M., Spurio, M., Stefani, F., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Vicini, P., Viola, S., Vivolo, D., Aiello, S, Leonora, E, Ameli, F, Anghinolfi, M, Anzalone, A, Barbarino, G, Barbarito, E, Barbato, F, Bersani, A, Beverini, N, Biagi, S, Bonori, M, Bouhadef, B, Bozza, C, Cacopardo, G, Capone, A, Caruso, F, Ceres, A, Chiarusi, T, Circella, M, Cocimano, R, Coniglione, R, Cordelli, M, Costa, M, D'Amico, A, De Asmundis, R, De Bonis, G, De Rosa, G, De Vita, R, Distefano, C, Fermani, P, Flaminio, V, Fusco, La, Garufi, F, Giordano, V, Giovanetti, G, Grella, G, Grimaldi, A, Habel, R, Imbesi, M, Kulikovsky, V, Lattuada, D, Leotta, G, Lonardo, A, Longhitano, F, Lo Presti, D, Maccioni, E, Margiotta, A, Marinelli, A, Martini, A, Masullo, R, Maugeri, F, Migliozzi, P, Migneco, E, Minutoli, S, Miraglia, A, Mollo, C, Mongelli, M, Morganti, M, Musico, P, Musumeci, M, Nicolau, Ca, Orlando, A, Papaleo, R, Pappalardo, V, Pellegrino, C, Perrina, C, Piattelli, P, Pugliatti, C, Pulvirenti, S, Raffaelli, F, Raia, G, Randazzo, N, Riccobene, G, Rovelli, A, Russo, A, Russo, Gv, Sapienza, P, Sciliberto, D, Sedita, M, Sgura, I, Shirokov, E, Simeone, F, Sipala, V, Sollima, C, Spina, M, Spurio, M, Stefani, F, Taiuti, M, Terreni, G, Trasatti, L, Trovato, A, Vicini, P, Viola, S, Vivolo, D, S Aiello, E Leonora, F Ameli, M Anghinolfi, A Anzalone, G Barbarino, E Barbarito, F Barbato, A Bersani, N Beverini, S Biagi, M Bonori, B Bouhadef, C Bozza, G Cacopardo, A Capone, F Caruso, A Cere, T Chiarusi, M Circella, R Cocimano, R Coniglione, M Cordelli, M Costa, A D'Amico, R De Asmundi, G De Boni, G De Rosa, R De Vita, C Distefano, P Fermani, V Flaminio, L A Fusco, F Garufi, V Giordano, G Giovanetti, G Grella, A Grimaldi, R Habel, M Imbesi, V Kulikovsky, D Lattuada, G Leotta, A Lonardo, F Longhitano, D Lo Presti, E Maccioni, A Margiotta, A Marinelli, A Martini, R Masullo, F Maugeri, P Migliozzi, E Migneco, S Minutoli, A Miraglia, C Mollo, M Mongelli, M Morganti, P Musico, M Musumeci, C A Nicolau, A Orlando, R Papaleo, V Pappalardo, C Pellegrino, C Perrina, P Piattelli, C Pugliatti, S Pulvirenti, F Raffaelli, G Raia, N Randazzo, G Riccobene, A Rovelli, A Russo, G V Russo, P Sapienza, D Sciliberto, M Sedita, I Sgura, E Shirokov, F Simeone, V Sipala, C Sollima, M Spina, M Spurio, F Stefani, M Taiuti, G Terreni, L Trasatti, A Trovato, P Vicini, S Viola, D Vivolo, S., Aiello, E., Leonora, F., Ameli, M., Anghinolfi, A., Anzalone, Barbarino, Giancarlo, E., Barbarito, Barbato, FELICIA CARLA TIZIANA, A., Bersani, N., Beverini, S., Biagi, M., Bonori, B., Bouhadef, C., Bozza, G., Cacopardo, A., Capone, F., Caruso, A., Cere, T., Chiarusi, M., Circella, R., Cocimano, R., Coniglione, M., Cordelli, M., Costa, A., D'Amico, R., De Asmundi, G., De Boni, DE ROSA, Gianfranca, R., De Vita, C., Distefano, P., Fermani, V., Flaminio, L. A., Fusco, Garufi, Fabio, V., Giordano, G., Giovanetti, G., Grella, A., Grimaldi, R., Habel, M., Imbesi, V., Kulikovsky, D., Lattuada, G., Leotta, A., Lonardo, F., Longhitano, D., Lo Presti, E., Maccioni, A., Margiotta, A., Marinelli, A., Martini, R., Masullo, F., Maugeri, P., Migliozzi, E., Migneco, S., Minutoli, A., Miraglia, C., Mollo, M., Mongelli, M., Morganti, P., Musico, M., Musumeci, C. A., Nicolau, A., Orlando, R., Papaleo, V., Pappalardo, C., Pellegrino, C., Perrina, P., Piattelli, C., Pugliatti, S., Pulvirenti, F., Raffaelli, G., Raia, N., Randazzo, G., Riccobene, A., Rovelli, A., Russo, G. V., Russo, P., Sapienza, D., Sciliberto, M., Sedita, I., Sgura, E., Shirokov, F., Simeone, V., Sipala, C., Sollima, M., Spina, M., Spurio, F., Stefani, M., Taiuti, G., Terreni, L., Trasatti, A., Trovato, P., Vicini, S., Viola, Vivolo, Daniele, Aiello, S., Leonora, E., Ameli, F., Anghinolfi, M., Anzalone, A., Barbarino, G., Barbarito, E., Barbato, F., Bersani, A., Beverini, N., Biagi, S., Bonori, M., Bouhadef, B., Bozza, C., Cacopardo, G., Capone, A., Caruso, F., Ceres, A., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Cordelli, M., Costa, M., D'Amico, A., De Asmundis, R., De Bonis, G., De Rosa, G., De Vita, R., Distefano, C., Fermani, P., Flaminio, V., Fusco, L. A., Garufi, F., Giordano, V., Giovanetti, G., Grella, G., Grimaldi, A., Habel, R., Imbesi, M., Kulikovsky, V., Lattuada, D., Leotta, G., Lonardo, A., Longhitano, F., Lo Presti, D., Maccioni, E., Margiotta, A., Marinelli, A., Martini, A., Masullo, R., Maugeri, F., Migliozzi, P., Migneco, E., Minutoli, S., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Papaleo, R., Pappalardo, V., Pellegrino, C., Perrina, C., Piattelli, P., Pugliatti, C., Pulvirenti, S., Raffaelli, F., Raia, G., Randazzo, N., Riccobene, G., Rovelli, A., Russo, A., Russo, G. V., Sapienza, P., Sciliberto, D., Sedita, M., Sgura, I., Shirokov, E., Simeone, F., Sipala, V., Sollima, C., Spina, M., Spurio, M., Stefani, F., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Vicini, P., Viola, S., and Vivolo, D.
Subjects: Physics, Photomultiplier, Instrument optimisation, business.industry, Large detector systems for particle and astroparticle physics, Single component, Cherenkov detectors, Electrical engineering, Phase (waves), Optical coupling, Optical Module, Optical detector readout concepts, optical detector readout concept, Large detector systems for particle and astroparticle physic, instrument optimization, large detector systems for particle and astroparticle physics, cherenkov detectors, business, Instrumentation, Mathematical Physics, Cherenkov detector, Voltage
Abstract: A 13-inch Optical Module (OM) containing a large-area (10-inch) photomultiplier was designed as part of Phase-2 of the NEMO project. An intense R&D activity on the photomultipliers, the voltage supply boards, the optical coupling as well as the study of the influences of the Earth's magnetic field has driven the choice of each single component of the OM. Following a well-established production procedure, 32 OMs were assembled and their functionality tested. The design, the testing and the production phases are thoroughly described in this paper. © 2013 IOP Publishing Ltd and Sissa Medialab srl.
Published: 2013

35. R&D studies of a RICH detector using pressurized C4F8O radiator gas and a CsI-based gaseous photon detector

Author: Rene Bellwied, D. W. Kim, J. S. Kim, F. Cindolo, I. Sgura, A. G. Agocs, A. G. Knospe, A. Harton, Guy Paic, K. Das, F. Piuz, J. Song, A. R. Timmins, Marc Weber, Daniel Berenyi, A. Di Mauro, Paolo Martinengo, G. Volpe, Peter Levai, F. Barile, László Oláh, I. K. Yoo, Gergely Gabor Barnafoldi, Laszlo Boldizsar, R. T. Jimenez, J. Yi, J. van Beelen, S. Pochybová, Lawrence Pinsky, D. D. Chinellato, Tinku Sarkar Sinha, Gyula Bencedi, C. Pastore, D. Varga, L. Xaplanteris, L. Das-Bose, Christina Markert, D. Di Bari, G. Hamar, L. Molnar, Gy L. Bencze, Vladimir Peskov, Eugenio Nappi, E. Futó, Sukalyan Chattopadhyay, M.E. Patino, Debasish Das, E. Garcia, G. de Cataldo, and László Kovács
Subjects: Physics, Nuclear and High Energy Physics, Large Hadron Collider, Physics::Instrumentation and Detectors, Cherenkov detector, business.industry, Detector, Ring-imaging Cherenkov detector, Particle identification, Photocathode, law.invention, Nuclear physics, Optics, law, Radiator (engine cooling), business, Instrumentation, Cherenkov radiation
Abstract: We report on studies of layout and performance of a new Ring Imaging Cherenkov detector using for the first time pressurized C 4 F 8 O radiator gas and a photon detector consisting of a MWPC equipped with a CsI photocathode. In particular, we present here the results of beam tests of a MWPC having an adjustable anode–cathode gap, aiming at the optimization of single photoelectron detection and Cherenkov angle resolution. This system was proposed as a Very High Momentum Particle Identification (VHMPID) upgrade for the ALICE experiment at LHC to provide charged hadron track-by-track identification in the momentum range 5–25 GeV/c.
Published: 2013
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36. Cell cycle perturbations and genotoxic effects in human primary fibroblasts induced by low-energy protons and X/?-rays

Author: Roberto Cherubini, Antonella Sgura, Antonio Antoccia, Francesco Berardinelli, Caterina Tanzarella, Maria Cavinato, S. Gerardi, Antoccia, Antonio, Sgura, A, Berardinelli, F, Cavinato, M, Cherubini, R, Gerardi, S. AND TANZARELLA C., Antoccia, A, Sgura, Antonella, Gerardi, S, and Tanzarella, C.
Subjects: Cell cycle checkpoint, DNA damage, Health, Toxicology and Mutagenesis, Binucleated cells, Cell Cycle Proteins, Radiation Dosage, Cell-cycle redistribution, Humans, H2AX, Radiology, Nuclear Medicine and imaging, Irradiation, Clonogenic assay, Cells, Cultured, Radiation, Chemistry, business.industry, X-Rays, Cell Cycle, Dose-Response Relationship, Radiation, Cell cycle, Fibroblasts, Molecular biology, Dose–response relationship, Gamma Rays, Cell Cycle Kinetics, Protons/γ, Protons, Nuclear medicine, business, DNA Damage
Abstract: The effect of graded doses of high-linear energy transfer (LET) low-energy protons to induce cycle perturbations and genotoxic damage was investigated in normal human fibroblasts. Furthermore, such effects were compared with those produced by low-LET radiations. HFFF2, human primary fibroblasts were exposed to either protons (LET = 28.5 keV/microm) or X/gamma-rays, and endpoints related to cell cycle kinetics and DNA damage analysed. Following both type of irradiations, unsynchronized cells suffered an inhibition to entry into S-phase for doses of 1-4 Gy and remained arrested in the G(1)-phase for several days. The levels of induction of regulator proteins, such as TP53 and CDKN1A showed a clear LET-dependence. DSB induction and repair as measured by scoring for gamma-H2AX foci indicated that protons, with respect to X-rays, yielded a lower number of DSBs per Gy, which showed a slower kinetics of disappearance. Such result was in agreement with the extent of MN induction in binucleated cells after X-irradiation. No significant differences between the two types of radiations were observed with the clonogenic assay, resulting anyway the slope of gamma-ray curve higher than that the proton one. In conclusion, in normal human primary fibroblasts cell cycle arrest at the G(1)/S transition can be triggered shortly after irradiation and maintained for several hours post-irradiation of both protons and X-rays. DNA damage produced by protons appears less amenable to be repaired and could be transformed in cytogenetic damage in the form of MN.
Published: 2009

37. Allergic contact dermatitis among construction workers detected in a clinic that did not specialize in occupational dermatitis

Author: Ida Duarte, Rogério Sgura Minnicelli, Juliana Mayumi Sumita, and Rosana Lazzarini
Subjects: Adult, Male, Gynecology, medicine.medical_specialty, Occupational Dermatitis, Construction Materials, business.industry, Construction Industry, Potassium dichromate, Dermatology, Middle Aged, medicine.disease, Dermatitis, allergic contact, Dermatitis, Occupational, Dermatitis, Allergic Contact, Occupational diseases, medicine, Humans, Rubber, Gloves, Protective, business, Allergic contact dermatitis, Retrospective Studies
Abstract: FUNDAMENTOS: A dermatite de contato e uma das dermatoses comumente relacionadas ao trabalho. Entre os pedreiros o cimento pode causar tanto a Dermatite Alergica de Contato quanto a Dermatite de Contato por Irritacao Primaria. Os equipamentos de protecao individual (luvas de borracha) podem favorecer o desenvolvimento de Dermatite Alergica de Contato. OBJETIVOS: 1) avaliar a frequencia de Dermatite Alergica de Contato entre os pedreiros entre Janeiro de 2005 e Dezembro de 2009; 2) determinar os principais agentes sensibilizantes; e 3) comparar os resultados obtidos entre o grupo de pedreiros com um grupo sem pedreiros. METODOS: analise retrospectiva de testes de contato. Pacientes foram separados em 2 grupos: 1) pedreiros e 2) nao pedreiros. RESULTADOS: dentre os 525 testes de contato analisados, 466 (90%) eram de nao pedreiros e 53 (10%) de pedreiros. As maos foram acometidas em 38 (61%). 13 pacientes (24%) tinham Dermatite de Contato por Irritacao Primaria e 40 (76%) tinham Dermatite Alergica de Contato. O grupo de pedreiros apresentou alta frequencia de sensibilizacao ao cimento, e 29 (54,7%) tinham sensibilizacao a agentes vulcanizadores da borracha. 23 pacientes (43,4%) pedreiros tinham sensibilizacao tanto ao cimento quanto a borracha. CONCLUSOES: entre os pedreiros a presenca de Dermatite Alergica de Contato ao cimento e a borracha no mesmo paciente foi comum e demonstrou a importância do teste de contato.
Published: 2012
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38. The ALICE-HMPID Detector Control System: Its evolution towards an expert and adaptive system

Author: C. Pastore, G. Volpe, A. Franco, I. Sgura, and G. De Cataldo
Subjects: Physics, Nuclear and High Energy Physics, Adaptive control, Physics::Instrumentation and Detectors, business.industry, Detector, Programmable logic controller, computer.software_genre, Expert system, Data acquisition, SCADA, Adaptive system, Control system, business, Instrumentation, computer, Computer hardware
Abstract: The High Momentum Particle IDentification (HMPID) detector is a proximity focusing Ring Imaging Cherenkov (RICH) for charged hadron identification. The HMPID is based on liquid C6F14 as the radiator medium and on a 10 m2 CsI coated, pad segmented photocathode of MWPCs for UV Cherenkov photon detection. To ensure full remote control, the HMPID is equipped with a detector control system (DCS) responding to industrial standards for robustness and reliability. It has been implemented using PVSS as Slow Control And Data Acquisition (SCADA) environment, Programmable Logic Controller as control devices and Finite State Machines for modular and automatic command execution. In the perspective of reducing human presence at the experiment site, this paper focuses on DCS evolution towards an expert and adaptive control system, providing, respectively, automatic error recovery and stable detector performance. HAL9000, the first prototype of the HMPID expert system, is then presented. Finally an analysis of the possible application of the adaptive features is provided.
Published: 2011
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39. Simulations and tests for metabolic radiotherapy with 188Re

Author: F. de Notaristefani, Antonella Sgura, R. Pellegrini, G. Pancaldi, Giuseppe Baldazzi, M. Bello, Giuliano Moschini, S. Lo Meo, M. Zuffa, A. Antoccia, Davide Camporese, Roberto Pani, Daniele Bernardini, P. Boccaccio, V. Orsolini Cencelli, Andrea Perrotta, Caterina Tanzarella, L. Melendez Alafort, Ulderico Mazzi, Dante Bollini, Nikolay Uzunov, Antonio Rosato, Francesco Navarria, A. Antoccia, G. Baldazzi, M. Bello, D. Bernardini, P. Boccaccio, D. Bollini, D. Camporese, F. De Notaristefani, S. Lo Meo, U. Mazzi, L. Melendez Alafort, G. Moschini, F.L. Navarria, V. Orsolini Cencelli, G. Pancaldi, R. Pani, R. Pellegrini, A. Perrotta, A. Rosato, A. Sgura, C. Tanzarella, N. Uzunov, M. Zuffa, Antoccia, A, Baldazzi, G, Bello, M, Bernardini, D, Boccaccio, P, Bollini, D, Camporese, D, De Notaristefani, F, Lo Meo, S, Mazzi, U, Alafort, Lm, Moschini, G, Navarria, Fl, Cencelli, Vo, Pancaldi, G, Pani, R, Pellegrini, R, Perrotta, A, Rosato, A, Sgura, Antonella, Tanzarella, C, Uzunov, N, Zuffa, M., A., Antoccia, G., Baldazzi, M., Bello, D., Bernardini, P., Boccaccio, D., Bollini, D., Camporese, DE NOTARISTEFANI, Francesco, S., LO MEO, U., Mazzi, L., MELENDEZ ALAFORT, G., Moschini, F. L., Navarria, V., ORSOLINI CENCELLI, G., Pancaldi, R., Pani, R., Pellegrin, A., Perrotta, A., Rosato, A., Sgura, C., Tanzarella, N., Uzunov, and M., Zuffa
Subjects: Nuclear and High Energy Physics, Biodistribution, Materials science, business.industry, medicine.medical_treatment, NUCLEAR IMAGING, Cancer, medicine.disease, HEPATOCELLULAR-CARCINOMA, NUCLEAR MEDICINE, Flat panel, Atomic and Molecular Physics, and Optics, In vitro, Radiation therapy, CRYSTAL SCINTILLATORS, GAMMA CAMERA, In vivo, TARGETED RADIOTHERAPY, Cancer cell, medicine, Dosimetry, cancer, Nuclear medicine, business
Abstract: 188 Re is a beta and gamma emitter used in metabolic radiotherapy. SCINTIRAD is a multidisciplinary collaboration that aims at determining the radio-response of 188 Re in cells “in vitro” and the biodistribution in different organs of mice “in vivo”, and studying the therapeutic effect on liver and other tumours induced in mice. Several tumour cell lines have been treated “in vitro” with a 188 Re solution. The dosimetry of 188 Re used to target the different lines of cancer cells has been evaluated using GEANT4, and preliminary results are presented. Studies to optimize the imaging of 188 Re “in vivo” have also continued, including the characterization of H8500 Flat Panel PMT and of LaBr 3 crystals, and the development of dedicated electronics.
Published: 2007

40. Acute myocardial infarction with occlusion of all three main epicardial coronary arteries: when Mother Nature takes care more than physicians

Author: Luigi Politi, Giuseppe Sangiorgi, Maria Grazia Modena, Rosario Rossi, Fabio Alfredo Sgura, and Daniel Monopoli
Subjects: Male, Conus artery, Collateral circulation, Stent thrombosis, medicine.medical_specialty, Coronary Vessel Anomalies, medicine.medical_treatment, Coronary, Myocardial Infarction, Collateral Circulation, Prosthesis Design, Settore MED/11, Coronary circulation, Fibrinolytic Agents, Coronary Circulation, Internal medicine, Coronary stent, medicine, Humans, cardiovascular diseases, Myocardial infarction, Angioplasty, Balloon, Coronary, business.industry, Angioplasty, Chronic Disease, Coronary Occlusion, Drug-Eluting Stents, Metals, Middle Aged, Platelet Aggregation Inhibitors, Stents, Thrombosis, Treatment Outcome, Cardiology and Cardiovascular Medicine, medicine.disease, Surgery, Coronary arteries, surgical procedures, operative, medicine.anatomical_structure, Coronary occlusion, Cardiology, business, Balloon, Artery
Abstract: Double-arterial coronary stent thrombosis in acute myocardial infarction (AMI) is an infrequent but severe complication, especially when the third main coronary artery is chronically occluded. The conus artery (CA) can serve as a major source of collateral when the left anterior descendent coronary artery (LAD) becomes obstructed. We report a case of a 48-year-old man presenting with AMI due to a very late double-arterial stent thrombosis (ST) following drug-eluting stent implantation and a chronic occlusion of LAD collateralized by a large anomalous CA, which provided for the entire vascularization of the coronary tree.
Published: 2010
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41. Randomized Clinical Trial on Short-Time Compression with Kaolin-Filled Pad: A New Strategy to Avoid Early Bleeding and Subacute Radial Artery Occlusion after Percutaneous Coronary Intervention

Author: Giuseppe M. Sangiorgi, Alessandro Aprile, Rosario Rossi, Giuseppe B. Zoccai, Maria G. Modena, Fabio Sgura, Luigi Politi, Daniel Monopoli, Catia Paganelli, and Andrea Amato
Subjects: medicine.medical_specialty, Percutaneous, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Activated clotting time, Percutaneous coronary intervention, Clopidogrel, Surgery, medicine.artery, Angioplasty, Hemostasis, medicine, Radiology, Nuclear Medicine and imaging, Radial artery, Cardiology and Cardiovascular Medicine, business, Blood coagulation test, medicine.drug
Abstract: Background: Despite the increasing use of transradial techniques for cardiac percutaneous procedures, none of the strategies commonly utilized for hemostasis has been able to reduce the occurrence of radial artery occlusion (RAO). The aim of this study was to evaluate the occurrence of 24-hour RAO and the rate of bleeding of a novel hemostatic device for radial closure after percutaneous interventions, in adjunct to short-time compression. Methods:Once the radial access was obtained, patients were randomized to 3 different strategies of radial closure: a short compression with the QuikClot R � Interventional TM pad (Z-Medica Corporation, Wallingford, CT, USA) (15 minutes, group 1), a short compression (15 minutes, group 2), and a conventional prolonged compression (2 hours, group 3) both without QuikClot R � utilization. Results:Fiftypatientsingroup1,20ingroup2,and50ingroup3wereenrolled.Thethreegroupswerehomogenous for baseline and procedural characteristics. None of patients in group 1 developed RAO, 1 (5%) occurred in group 2, and 5 (10%) in group 3 (P = 0.05). Active bleeding after compression removal occurred in 10 patients (20%) in group 1, 18 (90%) in group 2, and 1 (2%) in group 3 (P < 0.001). Among patients in group 1, at univariate analysis, the predictors of acute bleeding resulted in chronic therapy with clopidogrel (Odds Ratio 28.78, 95% Confidence Intervals 4.79‐172.82, P < 0.001) and high levels of activated clotting time (ACT) at the time of sheath removal (OR 1.02, 95% CI 1.00‐1.03, P = 0.009). At ROC analysis, the cutoff value of ACT for the risk of bleeding with a sensitivity of 80% and specificity of 75% was 287 seconds. Conclusions: Early sheet removal and short-time compression with QuikClot R � Interventional TM can reduce the rate of RAO after diagnostic or interventional procedures especially in patients not on double antiplatelet therapy. (J Interven Cardiol 2011;24:65–72)
Published: 2010
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42. Rationale and study design of the OISTER trial: Optical coherence tomography evaluation of stent struts re-endothelialization in patients with non-ST-elevation acute coronary syndromes – a comparison of the intrEpide tRapidil eluting stent vs. taxus drug-eluting stent implantation

Author: Giuseppe Sangiorgi, Fabio Alfredo Sgura, Daniel Monopoli, Luigi Politi, Maria Grazia Modena, Rosario Rossi, and D Iaccarino
Subjects: Vascular Endothelial Growth Factor A, Cardiac Catheterization, medicine.medical_specialty, Time Factors, Paclitaxel, medicine.medical_treatment, Coronary Angiography, Prosthesis Design, Coronary Restenosis, Restenosis, Internal medicine, medicine, Humans, Single-Blind Method, Longitudinal Studies, Acute Coronary Syndrome, Angioplasty, Balloon, Coronary, Endothelial dysfunction, Cell Proliferation, medicine.diagnostic_test, business.industry, ST elevation, Stent, Cardiovascular Agents, Drug-Eluting Stents, Thrombosis, General Medicine, medicine.disease, Coronary Vessels, Trapidil, Coronary arteries, Stenosis, Treatment Outcome, medicine.anatomical_structure, Italy, Research Design, Drug-eluting stent, OISTER trial, non-ST-elevation acute coronary syndromes, stent, Angiography, Cardiology, Endothelium, Vascular, Radiology, Cardiology and Cardiovascular Medicine, business, Biomarkers, Tomography, Optical Coherence
Abstract: Background Drug-eluting stents (DES) have been designed to prevent restenosis, but long-term clinical outcome may be offset by an increased risk of stent thrombosis, which is associated with suboptimal stent implantation or delayed re-endothelialization. DES implantation has also been associated with local persistent endothelial dysfunction. Conversely, Trapidil is a potent anti-inflammatory, vasodilatator and antiproliferative drug and several studies have shown anti-restenotic effects, suggesting substantial clinical benefits through the use of Trapidil-eluting DES. Study design This is a longitudinal, single-blind, double-arm, randomized multicenter study. Forty patients with non-ST-elevation acute coronary syndromes who present at the index procedure with multivessel coronary disease in the major epicardial coronary arteries will be enrolled. Patients should present a culprit lesion with stenosis 70% or more associated with another stenosis 70% or more in another coronary artery. Patients will be randomized in a 1: 1 fashion to receive either an Intrepide trapidil-eluting stent or a Taxus paclitaxel-eluting stent on the culprit lesion. After 90 days, the nonculprit lesion will be treated with the stent of the opposite randomization arm and optical coherence tomography (OCT) analysis of the index stented segment will be performed. Follow-up angiography, combined with vasomotor analysis of endothelial function by rapid atrial pacing, will be done at 12 months after the index procedure on both stents. To further characterize the status of the endothelium, serum measurement of vascular endothelial growth factor gradient between the aorta and 15 mm distal to the implanted stent will be performed at 12 months. The primary endpoint of the study is to compare stent struts re-endothelialization at 90 days by OCT. The secondary endpoint is to compare angiographic outcome and coronary endothelial function 12 months after the index procedure and to compare clinical outcome at 1 and 2 years between trapidil-eluting DES versus paclitaxel-eluting DES. Conclusion We hypothesize that the utilization of trapidil-eluting DES in the setting of acute coronary syndromes will be characterized by a greater early re-endothelialization associated with an antiproliferative effect offering a similar efficacy with a better safety profile compared with first-generation DES.
Published: 2010
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43. Deep sea tests of a prototype of the KM3NeT digital optical module: KM3NeT Collaboration

Author: Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., de Asmundis, R., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Belias, A., Berbee, E., van den Berg, A. M., Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Bianucci, S., Billault, M., Birbas, A., Boer Rookhuizen, H., Bormuth, R., Bouché, V., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Château, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Curtil, C., Cuttone, G., D’Amato, C., D’Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. J., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Eleftheriadis, C., Elsaesser, D., Enzenhöfer, A., Fermani, P., Fusco, L. A., Gajana, D., Gal, T., Galatà, S., Gallo, F., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Gracia Ruiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestädt, J., Hogenbirk, J., Hugon, C., Hößl, J., Imbesi, M., James, C., Jansweijer, P., Jochum, J., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Le Provost, H., Leisos, A., Lenis, D., Leonora, E., Lindsey Clark, M., Liolios, A., Llorens Alvarez, C. D., Löhner, H., Lo Presti, D., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Masullo, R., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Petridou, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, Th, Priede, M., Pühlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Royon, J., Saldaña, M., Samtleben, D. F E, Sanguineti, M., Santangelo, A., Sapienza, P., Savvidis, I., Schmelling, J., Schnabel, J., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Solazzo, M., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tézier, D., Théraube, S., Thompson, L. F., Timmer, P., Trapierakis, H. I., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H L, Yatkin, K., Zachariadou, K., Zonca, E., Zornoza, J. D., Zúñiga, J., Zwart, A., Sub Subatomic Physics (SAP), Subatomic Physics Institute, Sub Subatomic Physics (SAP), Subatomic Physics Institute, Adrian-Martinez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., de Asmundis, R., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Belias, A., Berbee, E., van den Berg, A. M., Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Bianucci, S., Billault, M., Birbas, A., Boer Rookhuizen, H., Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Curtil, C., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Eleftheriadis, C., Elsaesser, D., Enzenhofer, A., Fermani, P., Fusco, L. A., Gajana, D., Gal, T., Galata, S., Gallo, F., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Gracia Ruiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestadt, J., Hogenbirk, J., Hugon, C., Hossl, J., Imbesi, M., James, C., Jansweijer, P., Jochum, J., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Le Provost, H., Leisos, A., Lenis, D., Leonora, E., Lindsey Clark, M., Liolios, A., Llorens Alvarez, C. D., Lohner, H., Lo Presti, D., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J. A., Martini, A., Masullo, R., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Petridou, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, T., Priede, M., Puhlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Royon, J., Saldana, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Savvidis, I., Schmelling, J., Schnabel, J., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Solazzo, M., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L. F., Timmer, P., Trapierakis, H. I., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Yatkin, K., Zachariadou, K., Zonca, E., Zornoza, J. D., Zuniga, J., and Zwart, A.
Subjects: Physics, Photomultiplier, Photon, Physics and Astronomy (miscellaneous), 010308 nuclear & particles physics, business.industry, Physics::Instrumentation and Detectors, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, 01 natural sciences, Signal, Photocathode, Optics, KM3NeT, 0103 physical sciences, 14. Life underwater, Sensitivity (control systems), 010306 general physics, business, Engineering (miscellaneous), Cherenkov radiation
Abstract: The first prototype of a photo-detection unit of the future KM3NeT neutrino telescope has been deployed in the deep waters of the Mediterranean Sea. This digital optical module has a novel design with a very large photocathode area segmented by the use of 31 three inch photomultiplier tubes. It has been integrated in the ANTARES detector for in-situ testing and validation. This paper reports on the first months of data taking and rate measurements. The analysis results highlight the capabilities of the new module design in terms of background suppression and signal recognition. The directionality of the optical module enables the recognition of multiple Cherenkov photons from the same $^{40}$K decay and the localization bioluminescent activity in the neighbourhood. The single unit can cleanly identify atmospheric muons and provide sensitivity to the muon arrival directions.
Published: 2014

44. Peripheral blood lymphocyte decrease and micronucleus yields during radiotherapy

Author: E. Righi, Mm Trinci, C. Catena, D. Conti, P. Parasacchi, G. Trenta, Antonella Sgura, M. Trinci, Catena, C, Parasacchi, P, Conti, D, Sgura, Antonella, Trenta, G, Righi, E, Trinci, Mm, and Trinci, M.
Subjects: medicine.medical_specialty, Lymphocyte, medicine.medical_treatment, Urology, Ionizing radiation, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Lymphocytes, Radiosensitivity, Micronuclei, Chromosome-Defective, Aged, Pelvic Neoplasms, Radiotherapy, Radiological and Ultrasound Technology, business.industry, Dose-Response Relationship, Radiation, Middle Aged, In vitro, Radiation therapy, medicine.anatomical_structure, Head and Neck Neoplasms, Peripheral blood lymphocyte, Micronucleus test, business, Nuclear medicine, Micronucleus
Abstract: To investigate the relationship between lymphocyte decrease and cytogenetic response in individual patients undergoing radiotherapy.Peripheral blood lymphocytes obtained from 35 patients with pelvic and from 14 with head and neck tumours before and during radiotherapy were PHA-stimulated in vitro and the cultures prepared for the cytokinesis-block micronucleus test. For some patients only, the micronucleus test was carried out after 2 Gy in vitro X-irradiation, and 3-aminobenzamide (2 mM) was used to calculate the 3AB-index.The initially observed individual variation in the decrease of lymphocytes disappeared with increasing number of radiation exposures, reaching a stable level at about 500/microl lymphocytes in the blood. The slope of the relationship between the reciprocal of the lymphocyte decrease ratio and equivalent dose indicates the radiosensitivity of the lymphocyte pool in individual patients. The micronucleus test performed on lymphocytes obtained from patients during radiotherapy (in vivo) provided a lower cytogenetic response than the in vitro micronucleus yield for the same dose, so it was possible to calculate the cytogenetic recovery factor k. A correlation was found between the 3AB-index calculated before radiotherapy, and the recovery factor k.The 3AB-index, the micronucleus frequency after 2 Gy in vitro X-irradiation, and the cytogenetic recovery factor are proposed as predictive of individual response to radiotherapy.
Published: 1997
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45. Effects of mm-waves on human fibroblasts in-vitro

Author: Florigio Lista, Roberto Bei, Massimo Fantini, Antonella Sgura, S. Di Cristofaro, S. De Sanctis, Laura Masuelli, Emilio Giovenale, Elisa Regalbuto, Monica Benvenuto, A. De Amicis, Jessica Marinaccio, Valeria Franchini, Gian Piero Gallerano, Elisa Coluzzi, Andrea Doria, Giovenale, E., Doria, A., and Gallerano, G. P.
Subjects: Pulsed radiation, Optics, Materials science, business.industry, Terahertz radiation, Optoelectronics, Millimeter, Irradiation, Radiation, business
Abstract: A comprehensive study of the in-vitro exposure of human fibroblasts to millimeter waves in a wide spectral region is under way. The evaluation of different biological endpoints as result of exposure to pulsed radiation in the frequency range 100-150 GHz with the ENEA Compact FEL is reported. A new exposure set-up for irradiation to CW radiation in the range 18-40 GHz will also be presented. © 2015 IEEE.
Published: 2015
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46. Importance of the time of initiation of mineralocorticoid receptor antagonists on risk of mortality in patients with heart failure

Author: Rosario Rossi, Nicola Crupi, Francesca Coppi, Daniel Monopoli, and F Sgura
Subjects: Adult, Male, medicine.medical_specialty, Medicine (General), Spironolactone, Cohort Studies, chemistry.chemical_compound, Endocrinology, Mineralocorticoid receptor, R5-920, Internal medicine, Internal Medicine, medicine, Risk of mortality, Humans, In patient, angiotensinconverting enzyme inhibitor, aldosterone, AMI: acute myocardial infarction, ARA: aldosterone receptor antagonist, ARB: angiotensin receptor antagonist, HF: heart failure, LV: left ventricular, mortality, MRA: mineralocorticoid receptor antagonist, prognosis, RAAS: renin-angiotensin-aldosterone system, Aged, Aged, 80 and over, Canrenoic Acid, Female, Follow-Up Studies, Heart Failure, Middle Aged, Mineralocorticoid Receptor Antagonists, Prognosis, Survival Analysis, Treatment Outcome, Medicine (all) [ACE-I], Survival analysis, Aldosterone, business.industry, medicine.disease, chemistry, Heart failure, Cardiology, business, Cohort study
Abstract: Introduction: Several studies have definitively shown the benefit of mineralocorticoid receptor antagonists (MRAs) in patients with heart failure (HF). However, very few prior studies examined the relationship between the timing of initiation of MRAs and prognosis. In addition, on this topic, there is no information regarding the specific population of patients suffering a first episode of decompensated congestive HF. Methods: We studied a homogenous cohort of patients discharged alive from our hospital after a first episode of decompensated congestive HF, in order to clarify the association between time of aldosterone receptor antagonist (ARA) initiation (within the first 90 days after hospital discharge) and mortality. Our population was composed of a series of consecutive patients. All-cause mortality was compared between patients who initiated MRAs at discharge (early group) and those who initiated MRAs one month later and up to 90 days after discharge (delayed group). We used prescription time distribution matching to control for survival difference between groups. Results: The early and delayed groups consisted of 365 and 320 patients, respectively. During the one-year follow-up, a significant difference in mortality was demonstrated between groups. Adjusted hazard ratios (HRs) for early versus delayed initiation were 1.72 (95% confidence interval (CI) 0.96 to 2.84) at six months, and 1.93 (95% CI 1.18 to 3.14) at one year. Conclusions: Delay of MRA initiation up to 30 to 90 days after discharge implies a significant increase in mortality compared with MRA initiation at discharge, after a first episode of decompensate congestive HF.
Published: 2015

47. Fabrication and testing of an electrochemical microcell for in situ soft X-ray microspectroscopy measurements

Author: Alessandra Gianoncelli, Maya Kiskinova, Claudio Mele, Mauro Prasciolu, Ivonne Sgura, Benedetto Bozzini, Burkhard Kaulich, Alessandra, Gianoncelli, Burkhard, Kaulich, Maya, Kiskinova, Mele, Claudio, Mauro, Prasciolu, Sgura, Ivonne, and Bozzini, Benedetto
Subjects: History, Fabrication, Materials science, business.industry, Analytical chemistry, Electrolyte, Computer Science Applications, Education, Corrosion, Anode, Electrode, Optoelectronics, Microcell, Cyclic voltammetry, business, Lithography
Abstract: In this paper we report on the fabrication and testing of a novel concept of electrochemical microcell for in-situ soft X-ray microspectroscopy in transmission. The microcell, fabricated by electron-beam lithography, implements an improved electrode design, with optimal current density distribution and minimised ohmic drop, allowing the same three-electrode electrochemical control achievable with traditional cells. Moreover standard electroanalytical measurements, such as cyclic voltammetry, can be routinely performed. As far as the electrolyte is concerned, we selected a room-temperature ionic-liquid. Some of the materials belonging to this class, in addition to a broad range of outstanding electrochemical properties, feature two highlights that are crucial for in situ, soft X-ray transmission work: spinnability, enabling accurate thickness control, and stability to UHV, allowing operation of an open cell in the analysis chamber vacuum (10−6 mbar). The cell can, of course, be used also with non-vacuum stable electrolytes in the sealed version developed in previous work in our group. In this study, the microcell designed, fabricated and tested in situ by applying an anodic polarisation to a Au electrode and following the formation of a distribution of corrosion features. This specific material combination presented in this work does not limit the cell concept, that can implement any electrodic material grown by lithography, any liquid electrolyte and any spinnable solid electrolyte.
Published: 2013

48. Telomere length and long-term endurance exercise: does exercise training affect biological age? A pilot study

Author: Ingvild Vatten Alsnes, Eivind Brønstad, Ida Beate Øyen Østhus, Javaid Nauman, Ulrik Wisløff, Antonella Sgura, Francesco Berardinelli, Per Kristian Støbakk, Tommy Aune Rehn, Håvard Hatle, Osthus, Ib, Sgura, Antonella, Berardinelli, Francesco, Alsnes, Iv, Brønstad, E, Rehn, T, Støbakk, Pk, Hatle, H, Wisløff, U, and Nauman, J.
Subjects: Male, Gerontology, Aging, Anatomy and Physiology, Physical fitness, lcsh:Medicine, Pilot Projects, Cardiovascular, Running, Molecular Cell Biology, lcsh:Science, License, long term excercise, telomere, Multidisciplinary, Chromosome Biology, Genomics, Telomere, Telomeres, Medicine, Research Article, Adult, medicine.medical_specialty, Biological age, Biology, Affect (psychology), Oxygen Consumption, Telomere Homeostasis, Endurance training, medicine, Humans, Genetic Testing, Sports and Exercise Medicine, Muscle, Skeletal, Aged, Clinical Genetics, business.industry, aging, lcsh:R, Term (time), Cross-Sectional Studies, Physical Fitness, Physical Endurance, Physical therapy, lcsh:Q, Physiological Processes, business, Attribution
Abstract: Background: Telomeres are potential markers of mitotic cellular age and are associated with physical ageing process. Long-term endurance training and higher aerobic exercise capacity (VO2max) are associated with improved survival, and dynamic effects of exercise are evident with ageing. However, the association of telomere length with exercise training and VO2max has so far been inconsistent. Our aim was to assess whether muscle telomere length is associated with endurance exercise training and VO2max in younger and older people. Methods: Twenty men; 10 young (22–27 years) and 10 old (66–77 years), were studied in this cross-sectional study. Five out of 10 young adults and 5 out of 10 older were endurance athletes, while other halves were exercising at a medium level of activity. Mean telomere length was measured as telomere/single copy gene-ratio (T/S-ratio) using quantitative real time polymerase chain reaction. VO2max was measured directly running on a treadmill. Results: Older endurance trained athletes had longer telomere length compared with older people with medium activity levels (T/S ratio 1.12±0.1 vs. 0.92±0.2, p = 0.04). Telomere length of young endurance trained athletes was not different than young non-athletes (1.47±0.2 vs. 1.33±0.1, p = 0.12). Overall, there was a positive association between T/S ratio and VO2max (r = 0.70, p = 0.001). Among endurance trained athletes, we found a strong correlation between VO2max and T/S ratio (r = 0.78, p = 0.02). However, corresponding association among non-athlete participants was relatively weak (r = 0.58, p = 0.09). Conclusion: Our data suggest that VO2max is positively associated with telomere length, and we found that long-term endurance exercise training may provide a protective effect on muscle telomere length in older people. © 2012 Østhus et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Published: 2012

49. Calibration curves for biological dosimetry by fluorescence in situ hybridisation

Author: Caterina Tanzarella, G. Gensabella, L. Stonati, Paola Scampoli, Mariagabriella Pugliese, A. Sgura, G. Grossi, Marco Durante, A. Testa, G Gialanella, Stronati, L, Durante, Marco, Gensabella, G, Gialanella, G, Gross, Gf, Pugliese, Mariagabriella, Scampoli, Paola, Sgura, A, Testa, A, Tanzarella, C., Stronati, L., M., Durante, Gialanella, Giancarlo, G. F., Grossi, A., Sgura, A., Testa, C., Tanzarella, Durante, M, Pugliese, M, Scampoli, P, and Sgura, Antonella
Subjects: Adult, Male, Radiobiology, Calibration curve, Chromosome Disorders, Radiation Dosage, chemistry.chemical_compound, Blood serum, Dosimetry, Humans, Radiology, Nuclear Medicine and imaging, Lymphocytes, Cobalt Radioisotopes, Metaphase, In Situ Hybridization, Fluorescence, Chromosome Aberrations, Radiation, Chi-Square Distribution, Radiological and Ultrasound Technology, Colcemid, business.industry, Public Health, Environmental and Occupational Health, Dose-Response Relationship, Radiation, General Medicine, Molecular biology, Chromosome 4, chemistry, Gamma Rays, Premature chromosome condensation, Calibration, Nuclear medicine, business
Abstract: Dose-response curves were measured for the induction of chromosomal aberrations in peripheral blood lymphocytes after acute exposure in vitro to 60Co gamma rays. Blood was obtained from four different healthy donors, and chromosomes were either observed at metaphase, following colcemid accumulation, or prematurely condensed by calyculin A. Cells were analysed in three different Italian laboratories. Chromosomes 1, 2, and 4 were painted, and simple-type interchanges between painted and non-painted chromosomes were scored in cells exposed in the dose range 0.1-3.0 Gy. The chemical-induced premature chromosome condensation method was also used combined with chromosome painting (chromosome 4 only) to determine calibration curves for high dose exposures (up to 20 Gy X rays). Calibration curves described in this paper will be used in our laboratories for biological dosimetry by fluorescence in situ hybridisation.
Published: 2001

50. Travelling Waves in a Reaction-Diffusion Model for Electrodeposition

Author: Benedetto Bozzini, Deborah Lacitignola, Ivonne Sgura, Bozzini, Benedetto, Lacitignola, D, and Sgura, Ivonne
Subjects: Surface (mathematics), General Computer Science, Fisher equation, Space (mathematics), Theoretical Computer Science, Optics, Reaction–diffusion system, Method of Lines, Reaction-diffusion system, Travelling waves, High order finite difference schemes, Mathematics, Coupling, Numerical Analysis, business.industry, Applied Mathematics, Mathematical analysis, Method of lines, Finite difference, High order finite difference scheme, Electrochemical modeling, Traveling wave, Chemical species, Modeling and Simulation, business
Abstract: In this paper we consider an analytical and numerical study of a reaction-diffusion system for describing the formation of transition front waves in some electrodeposition (ECD) experiments. Towards this aim, a model accounting for the coupling between morphology and composition of one chemical species adsorbed at the surface of the growing cathode is addressed. Through a phase-space analysis we prove the existence of travelling waves, moving with specific wave speed. The numerical approximation of the PDE system is performed by the Method of Lines (MOL) based on high order space semi-discretization by means of the Extended Central Difference Formulae (D2ECDF) introduced in [1]. First of all, to show the advantage of the proposed schemes, we solve the well-known Fisher scalar equation, focusing on the accurate approximation of the wave profile and of its speed. Hence, we provide numerical simulations for the electrochemical reaction-diffusion system and we show that the results obtained are qualitatively in good agreement with experiments for the electrodeposition of Au-Cu alloys.
Published: 2011

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