1. Efficacy and safety of tofacitinib in rheumatoid arthritis-associated interstitial lung disease: TReasure real-life data
- Author
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Emre Tekgöz, Hasan Satış, Umut Kalyoncu, Orhan Küçükşahin, Belkıs Nihan Coşkun, Sedat Kiraz, Veli Yazisiz, Emre Bilgin, Canberk Sami Başıbüyük, Gezmiş Kimyon, Aşkın Ateş, Abdurrahman Tufan, Teoman Yusuf Cesur, Abdulsamet Erden, Serdar Alkan, Ihsan Ertenli, Burcu Yağız, and Cemal Bes
- Subjects
Oncology ,Male ,medicine.medical_specialty ,Tofacitinib ,business.industry ,Immunology ,Interstitial lung disease ,respiratory system ,medicine.disease ,behavioral disciplines and activities ,Real life data ,respiratory tract diseases ,Arthritis, Rheumatoid ,Pyrimidines ,Piperidines ,Rheumatology ,Rheumatoid arthritis ,Internal medicine ,Medicine ,Humans ,Immunology and Allergy ,Female ,Treasure ,business ,Lung Diseases, Interstitial - Abstract
Background/Aim: Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is a major concern in RA patients and events of ILD have been reported in patients treated with tofacitinib in RA clinical trials and in the post-marketing setting. The aim of this study was to assess the real-life efficacy and safety of tofacitinib in patients with RA-ILD. Methods RA patients with ILD diagnosis based on the HRCT images of the lungs from eight different centers recruited to study. As a control group, RA patients without ILD under tofacitinib was included. Demographic data, patients’ characteristics, available pulmonary function tests regarding RA and RA-ILD at the visit in which tofacitinib was initiated and for the last follow-up visit under tofacitinib were recorded. Reasons of tofacitinib discontinuation were also recorded. Drug retention rates were compared by log-rank test. p value
- Published
- 2021