65 results on '"Seok Jin Choi"'
Search Results
2. The seasonal pattern of restless legs syndrome in a sample from the Korean Health Insurance Review and Assessment Service national database
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Seok Jin Choi, Seong Min Oh, Yu Jin Lee, So Young Yoon, Kyung Lak Son, and Mi Hyun Lee
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Sample (statistics) ,Restless Legs Syndrome ,Republic of Korea ,mental disorders ,Health insurance ,Humans ,Medicine ,Restless legs syndrome ,Retrospective Studies ,Service (business) ,Insurance, Health ,business.industry ,medicine.disease ,Scientific Investigations ,humanities ,body regions ,Neurology ,National health insurance ,Family medicine ,Dopamine Agonists ,National database ,Willis-Ekbom disease ,Seasons ,Neurology (clinical) ,business - Abstract
STUDY OBJECTIVES: To assess the seasonality of restless legs syndrome (RLS) using data from the Korean national health insurance database. METHODS: We retrospectively reviewed a randomly selected sample representing 3% of the national health insurance claims database in South Korea. From this sample, we obtained the monthly numbers of patients with RLS and diagnoses from 2009 to 2016, along with prescriptions for monthly dopamine agonists and clonazepam for patients with RLS from 2009 to 2013. Total dopamine agonist and clonazepam doses were converted to levodopa-equivalent doses, and the monthly cumulative prescription dose was calculated. Cosinor analysis was used to evaluate the seasonal pattern of each variable. RESULTS: This study included 11,466 patients with RLS and their diagnoses and 4,887 prescriptions for dopamine agonists and clonazepam. There were significant seasonal patterns in the numbers of patients with RLS (P < .001) and diagnoses (P < .001), both of which peaked in August. The magnitude of the greatest difference in the number of patients with RLS between August (highest) and February (lowest) was 29.96% (95% confidence interval, 24.03–100.80), and that of the number of RLS diagnoses was 39.56% (95% confidence interval, 31.24–47.89). The cumulative prescription dose of medication showed no significant seasonality. CONCLUSIONS: Our findings suggest that the prevalence of RLS is seasonally affected, with an increase during summer. CITATION: Oh SM, Son K-L, Choi S-J, Lee MH, Yoon SY, Lee YJ. The seasonal pattern of restless legs syndrome in a sample from the Korean health insurance review and assessment service national database. J Clin Sleep Med. 2021;17(5):1051–1056.
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- 2021
3. Risk factors for developing post‐thymectomy myasthenia gravis in patients with thymoma
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Jung-Joon Sung, Yoon-Ho Hong, Je Young Shin, Chang Hyun Kang, Seonkyung Lee, Sung Min Kim, Jin Ah Kim, Ahwon Kim, Hyoshin Son, and Seok Jin Choi
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Thymoma ,Physiology ,medicine.medical_treatment ,Extended thymectomy ,030105 genetics & heredity ,Gastroenterology ,World health ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Risk Factors ,Physiology (medical) ,Internal medicine ,Myasthenia Gravis ,Humans ,Medicine ,Receptors, Cholinergic ,In patient ,Retrospective Studies ,business.industry ,Hazard ratio ,Thymus Neoplasms ,Middle Aged ,Thymectomy ,medicine.disease ,Myasthenia gravis ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Partial thymectomy - Abstract
BACKGROUND Thymectomy is required for the treatment of thymoma-associated myasthenia gravis (MG). However, MG may develop only after thymectomy, a condition known as post-thymectomy MG. This study aimed to investigate the risk factors for post-thymectomy MG in patients with thymoma. METHODS We retrospectively identified 235 patients with thymoma who underwent thymectomy at a single hospital from January 2008 to December 2017: 44 with preoperatively diagnosed MG were excluded, leaving 191 patients in the final analysis. Univariable survival analyses using Cox proportional hazards regression model and Kaplan-Meier estimate were conducted to identify risk factors for post-thymectomy MG. RESULTS Post-thymectomy MG developed in 4.2% (8/191) of the patients with thymoma between 18 days and 108 mo after surgery. Hazard ratios (HRs) of pre- and postoperative anti-acetylcholine receptor antibody (AChR-Ab) titers were 2.267 (P = .002) and 1.506 (P
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- 2021
4. Reporting a Case of False-positive Radio-iodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor
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Soo Jin Jung, Yun Mi Kim, Seok Mo Lee, Seok Jin Choi, Min Jeong Kwon, Soon Hee Lee, Jeong Hyun Park, Seok Jun Moon, Hye Rim Kang, Hee Soo Jung, and Tae Kyoon Kim
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,123i mibg ,Lymph node biopsy ,Scintigraphy ,medicine.disease ,Epigastric pain ,Left adrenal gland ,Metastatic carcinoma ,Pheochromocytoma ,Male patient ,Medicine ,Radiology ,business - Abstract
123I-Metaiodobenzylguanidine (MIBG) scintigraphy is a widely used functional imaging tool with a high degree of sensitivity and specificity in diagnosis of pheochromocytoma. However, rare cases of false positive reactions have been reported. A 67-year-old male patient was admitted with epigastric pain. Abdominal computed tomography (CT) revealed a heterogeneous left adrenal mass 6 cm in diameter; following hormone testing, 123I-MIBG scintigraphy was performed to determine the presence of pheochromocytoma, which confirmed eccentric uptake by a large left adrenal gland mass. Chest CT and PET-CT confirmed metastatic lymphadenopathy; therefore, endobronchial ultrasound transbronchial needle aspiration was performed. Metastatic carcinoma of unknown origin was suspected from a lymph node biopsy and surgical resection was performed for definitive diagnosis and correction of excess hormonal secretion. A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of MIBG demonstrated by scintigraphy. When the degree of MIBG uptake is low-grade in relationship to a large tumor mass, then a false-positive result should be entertained, particularly in the absence of typical clinical and biochemical features of pheochromocytoma.
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- 2021
5. Associations between HLA-A, -B, and -C alleles and iodinated contrast media-induced hypersensitivity in Koreans
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Minkyung Oh, Jung Eun Seol, Jong-Lyul Ghim, Jae-Gook Shin, Seok Jin Choi, Chan Sun Park, Mi-Yeong Kim, and Eun Young Kim
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HLA Class I ,medicine.medical_specialty ,business.industry ,Iopromide ,Non-immediate Hypersensitivity ,Korean ,Odds ratio ,Iobitridol ,Immediate Hypersensitivity ,Iodixanol ,Gastroenterology ,Confidence interval ,chemistry.chemical_compound ,chemistry ,Internal medicine ,embryonic structures ,medicine ,Outpatient clinic ,Pharmacology (medical) ,Original Article ,Iohexol ,business ,Iodinated Contrast Media ,Genotyping ,medicine.drug - Abstract
A common cause of drug hypersensitivity reactions is iodinated contrast media (ICM). ICM-induced hypersensitivity had been considered to be a non-immunological reaction, but evidence for an immunological mechanism has increased recently. Thus, we evaluated whether HLA-A, -B, and -C alleles were associated with ICM-induced hypersensitivity. In total, 126 patients who underwent contrast-enhanced computed tomography studies through outpatient clinics at a tertiary referral hospital between 2008 and 2012 were assessed. Sixty-one patients experienced ICM-induced hypersensitivity and the remainder, 65, were ICM-tolerant patients (control). ICM-induced hypersensitivity patients showed 51 with immediate, 7 with non-immediate, 3 with both or mixed type. HLA-A, -B, and -C genotyping was performed using a PCR sequence-based typing method. Four kinds of ICM were used: iopromide, iohexol, iobitridol, and iodixanol. The most used ICM among the hypersensitivity patients was iopromide. Significant difference in the frequency of HLA-B*58:01 (odds ratios [OR], 3.90; p = 0.0200, 95% confidence interval [CI], 1.16-13.07) was observed between ICM-induced immediate hypersensitivity and control. There were statistically significant differences in the frequencies of the HLA-B*38:02 (OR, 10.24; p = 0.0145; 95% CI, 1.09-96.14) and HLA-B*58:01 (OR, 3.98; p = 0.0348; 95% CI, 1.03-15.39) between iopromide-induced immediate hypersensitivity and control. The mechanism of ICM-induced hypersensitivity remains unknown, but this study showed associations, although weak, with HLA-B*58:01 alleles for ICM-induced immediate hypersensitivity and HLA-B*38:02 and HLA-B*58:01 for iopromide-induced immediate hypersensitivity as risk predictors. Further studies are needed to validate the associations in larger samples and to identify the functional mechanism behind these results.
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- 2021
6. EBI2-expressing B cells in neuromyelitis optica spectrum disorder with AQP4-IgG: Association with acute attacks and serum cytokines
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Je Young Shin, Seok Jin Choi, Seolhee Baek, Youn Soo Choi, Sung Min Kim, Boram Kim, Jung-Joon Sung, and So Hyun Ahn
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Adult ,Male ,Immunology ,Cell ,CD19 ,Receptors, G-Protein-Coupled ,Young Adult ,Immunology and Allergy ,Medicine ,Humans ,Receptor ,Interleukin 6 ,Aged ,Aquaporin 4 ,B-Lymphocytes ,Neuromyelitis optica ,biology ,business.industry ,Multiple sclerosis ,Neuromyelitis Optica ,Interleukin ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Neurology ,Immunoglobulin G ,Acute Disease ,biology.protein ,Cytokines ,Female ,sense organs ,Neurology (clinical) ,business - Abstract
Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is important in regulating B cell activation. We investigated whether EBI2 expression on B cells is associated with acute attacks in neuromyelitis optica spectrum disorder with aquaporin-4 IgG (AQP4-IgG(+) NMOSD). Blood samples were collected from patients with AQP4-IgG(+) NMOSD, multiple sclerosis (MS), and patients without inflammatory demyelinating diseases (non-IDD controls). CD19+ B cells and CD4+ T cells were analyzed for surface expression of EBI2. Serum cytokine levels were also analyzed. The EBI2+CD19+ to EBI2–CD19+ cell ratio was significantly higher in patients with AQP4-IgG(+) NMOSD enrolled within 2 months of an attack than in those with non-IDDs (p = 0.007) and MS (p = 0.003). Patients with AQP4-IgG(+) NMOSD enrolled within 2 months of an attack had a higher EBI2+CD19+ cell frequency than patients with AQP4-IgG(+) NMOSD enrolled 2 months after a recent attack (p = 0.001). The EBI2+CD19+ cell frequency was positively correlated with interleukin (IL)-6 and IL-10. EBI2 expression on B cells could be associated with acute attacks of AQP4-IgG(+) NMOSD, possibly through IL-6- or IL-10-related pathways.
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- 2021
7. Thromboembolic complications following intravenous immunoglobulin therapy in immune-mediated neurological disorders
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Soo Hyun Park, Yong-Chan Kim, Woochang Chun, and Seok-Jin Choi
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Male ,medicine.medical_specialty ,TEC ,Critical Illness ,Guillain-Barre Syndrome ,03 medical and health sciences ,0302 clinical medicine ,Intravenous Immunoglobulin Therapy ,hemic and lymphatic diseases ,Physiology (medical) ,Internal medicine ,Thromboembolism ,Myasthenia Gravis ,medicine ,Humans ,Adverse effect ,Ischemic Stroke ,Retrospective Studies ,Aged, 80 and over ,Leukopenia ,business.industry ,Immunization, Passive ,Aseptic meningitis ,Immunoglobulins, Intravenous ,General Medicine ,Middle Aged ,medicine.disease ,Myasthenia gravis ,Blood pressure ,Neurology ,030220 oncology & carcinogenesis ,Surgery ,Female ,Neurology (clinical) ,medicine.symptom ,Nervous System Diseases ,business ,Complication ,Pulmonary Embolism ,030217 neurology & neurosurgery - Abstract
Background Minor adverse events of intravenous immunoglobulin (IVIg) include flu-like symptoms, eczematous skin reaction, electrolyte disturbance, and transient leukopenia. On rare occasions, serious complications such as aseptic meningitis, arrhythmia, decrease in blood pressure, and thromboembolic complications (TEC) have been described. The current study aimed to understand the frequency and clinical features of TEC related to IVIg administration in patients with immune-mediated neurological disorders. Methods We conducted a retrospective chart review of hospitalized patients with immune-mediated neuromuscular or neuroimmunological disorders treated with IVIg from January 2018 to March 2020 in a single tertiary hospital. Results During the study period, 61 patients were treated with a total of 364 IVIg infusions over 84 treatment courses. Among them, we identified 3 TEC cases that occurred during or after the completion of IVIg therapy: two patients with myasthenia gravis (F/60 and F/80) and one patient with Guillain-Barre syndrome (F/79) had undergone arterial TEC (two for ischemic stroke and one for pulmonary thromboembolism). The rates of TEC per patient, per treatment course, and per infusion were 4.91% (3/61), 3.57% (3/84), and 0.82% (3/364), respectively. Conclusion The risk of developing TEC upon receiving IVIg infusions is generally low in patients with immune-mediated neurological disorders; however, IVIg-related TEC should be cautiously monitored for in critically ill elderly patients with vascular risk factors, especially those suffering from myasthenic crisis.
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- 2020
8. Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: Subgroup analyses of the randomized controlled phase 3 PREVENT trial
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Jacqueline Palace, Dean M. Wingerchuk, Kazuo Fujihara, Achim Berthele, Celia Oreja-Guevara, Ho Jin Kim, Ichiro Nakashima, Michael Levy, Murat Terzi, Natalia Totolyan, Shanthi Viswanathan, Kai-Chen Wang, Amy Pace, Marcus Yountz, Larisa Miller, Róisín Armstrong, Sean Pittock, Daniel Julio Muñoz, Jorge David Amor, Carolina Bocchiardo, Julieta Iourno Danielle, Alfredo Laffue, Carolina Daniela Diaz Obregon, Maria Fernanda Paez, Roberto Martin Perez, Viviana Ana Maria Rocchi, Loreley Deborah Teijeiro, Jesica Gómez, Andres Maria Villa, Florencia Aguirre, Victoria Carla Fernández, Ramon F. Goicoechea, Luciana Melamud, Ana Stillman, Mariana de Virgiliis, Fatima Pagani Cassara, Marta Cordoba, Maria Teresa Gutierrez, Mariana Ingolotti, Natalia Larripa, Anahi Lupinacci, Josefina Arroyo, Alejandra Romano, Mariana Foa Torres, Carlos Héctor Ballario, Ana Elisa Chiesa, Hernán Gustavo Gómez, Hernán Gabriel Lattini, Carolina Natalia Mainella, Gisel Edith Bolner, María Soledad Eschoyez, Simon Andrew Broadley, Saman Heshmat, Arman Sabet, Andrew Swayne, Susan Freeman, Sofia Jimenez Sanchez, Neil Shuey, Linda Dalic, Ann French, Guru Kuma, Joshua Laing, Lai Yin Law, Jennifer MacIntyre, Andrew Neal, Christopher Plummer, Prashanth Ramachandran, Leslie Sedal, Ian Wilson, Antony Winkel, Wenwen Zhang, Tina Chen, Rani Watts, Michael Barnett, Joshua Barton, Heidi Beadnall, Justin Garber, Todd Andrew Hardy, Benjamin Trewin, Marinda Taha, Deleni Walters, Federico Arturo Silva Sieger, Nhora Patricia Ruiz Alfonso, Anna Maria Pinzon Camacho, Alexander Pabón Moreno, Jorge Armando Castellanos Prad, Adriana Paola Duarte Rueda, Tatiana Castillo, Karol Melissa Castillo Gonzalez, Martha Yolanda Moreno Pico, Judith Castill, Mario Habek, Ivan Adamec, Barbara Barun, Luka Crnosija, Tereza Gabelic, Petra Nytrova, Eva Krasulova, Jana Pavlickova, Michaela Tyblova, Jana Zubkova, Thor Petersen, Gro Helen Dale, Peter Vestergaard Rasmussen, Morten Stilund, Kristina Bacher Svendsen, Vivi Brandt, Nicolas Collongues, Marie-Celine Fleury, Laurent Kremer, Sandrine Bendele, Valérie Neff, Ricarda Diem, Michael Platten, Anne Berberich, Jonabelle Jansen, Hannah Jaschoneck, Brigitte Wildemann, Ursula Aures, Tanja Brandenburger, Tanja Haut, Maria-Lourdes Treceno Fernández, Lilian Aly, Kirsten Brinkhoff, Dorothea Buck, Daniel Golkowski, Mirjam Hermisson, Muna-Miriam Hoshi, Miriam Kaminski, Markus Christian Kowarik, Helena Kronsbein, Klaus Lehmann-Horn, Viola Maria Pongratz, Andreas Schweiker, Lisa-Ann Leddy, Silvia Mueller, Kim Obergfell, Marion Wanka, Uwe Klaus Zettl, Jan Klinke, Micha Loebermann, Stefanie Meister, Florian Rimmele, Alexander Winkelmann, Ina Schroeder, Alexander Yuk-Lun Lau, Lisa Wing-Chi Au, Florence Sin-Ying Fan, Vincent Hing-Lung Ip, Karen Ka-Yan Ma, Sze-Ho Ma, Vincent Chung-Tong Mok, Cheryl Chung-Kwan Au, Pauline Wing-Lam Kwan, Francesco Patti, Andrea Salvatore Caramma, Clara Grazia Chisari, Salvatore Lo Fermo, Silvia Messina, Maria Projetto, Cinzia Caserta, Alessandro Filla, Teresa Costabile, Chiara Pane, Francesco Sacca, Angela Marsili, Giorgia Puorro, Roberto Bergamaschi, Eliana Berra, Giulia Mallucci, Cinzia Fattore, Claudio Gasperini, Simonetta Galgani, Shalom Haggiag, Serena Ruggieri, Claudio Vento, Esmeralda Maria Quartuccio, Carlo Pozzilli, Valeria Teresa Barletta, Giovanna Borriello, Laura De Giglio, Fabiana Marinelli, Miriam Tasillo, Alessandra Amadori, Mariano Fischetti, Flavia Gurreri, Masahiro Mori, Hiroki Masuda, Ryohei Ohtani, Yukari Sekiguchi, Tomohiko Uchida, Akiyuki Uzawa, Hiromi Ito, Emi Kabasawa, Yoko Kaneko, Takuya Matsushita, Dai Matsuse, Hiroyuki Murai, Shintaro Hayashi, Katsuhisa Masak, Hidenori Ogata, Koji Shinoda, Taira Uehara, Mitsuru Watanabe, Hiroo Yamaguchi, Ryo Yamasaki, Tomomi Yonekawa, Maki Jingu, Makiko Nagano, Yumiko Nakamura, Yoshiko Sano, Manabu Araki, Youwei Lin, Madoka Mori, Yohei Mukai, Terunori Sano, Wakiro Sato, Naoya Gogun, Yuriko Maeda, Asami Nishimoto, Sachiko Tsukamoto, Ritsuko Yanagi, Takahiko Saida, Shinichi Nakamura, Tetsuya Nasu, Kyoko Saida, Yuko Shikata, Yoshimi Kodani, Megumi Saeki, Yukako Sawada, Hiroo Yoshikawa, Takashi Kimura, Masamitsu Nishi, Shun Sakamoto, Shinichiro Ukon, Shohei Watanabe, Saori Ebisuya, Nami Kimura, Manami Matsuura, Yukie Morisaki, Yoshiko Muroi, Kuniko Onishi, Ikuko Oshima, Yuki Washino, Tomomi Yamashita, Tatsuro Misu, Kimihiko Kaneko, Masaaki Kato, Hiroshi Kuroda, Kazuhiro Kurosawa, Shuhei Nishiyama, Hirohiko Ono, Yoshiki Takai, Keiko Abe, Hitomi Hoshi, Mari Jinushi, Azusa Oyama, Motonari Sakuma, Yuko Sawada, Satoru Ishibashi, Takanori Yokota, Yoichiro Nishida, Kokoro Ozaki, Nobuo Sanjo, Nozomu Sato, Fuki Denno, Haruko Hiraki, Yumi Matsubara, Takashi Kanda, Masaaki Abe, Masaya Honda, Motoharu Kawai, Michiaki Koga, Toshihiko Maeda, Junichi Ogasawara, Masatoshi Omoto, Yasuteru Sano, Ryota Sato, Fumitaka Shimizu, Hideki Arima, Sachie Fukui, Yoshiko Ishikawa, Tomoko Koyama, Shigemi Shimose, Hirokazu Shinozaki, Masanori Watanabe, Sachi Yasuda, Chieko Yoshiwaka, Suffian Adenan, Mohd Azman M Aris, Ahmad Shahir bin Mawardi, Muhammad Al Hafiz Adnan, Nanthini Munusamy, Siti Nur Omaira Razali, Punitha Somasundram, Jae Won Hyun, In Hye Jeong, Su-Hyun Kim, Hyun-June Shin, Ji Sung Yoo, HyunMin Jang, AeRan Joung, Byung-Jo Kim, Seol-Hee Baek, Jung Bin Kim, Yoo Hwan Kim, Yong Seo Koo, Chan Nyoung Lee, Hung Youl Seok, Jinhee Hwang, Sung Min Kim, So Hyun Ahn, Kyomin Choi, Seok-Jin Choi, Jun-Soon Kim, Young Nam Kwon, Je-Young Shin, Hyeonju Kwon, Byoung Joon Kim, Eun Bin Cho, Hye-Jin Cho, Misong Choi, DongSun Kim, Ju Hyeon Kim, SeungJu Ki, Hye Lim Lee, Kwang-Ho Lee, Ju-Hong Min, Ji-Hyung Park, Jinmyoung Seok, Eunhwa Choi, Sang Ae Park, Seung Min Kim, Ha-Neul Jeong, Bong Jeongbin, Jin Woo Jung, Seung Woo Kim, Yool-hee Kim, Hyung Seok Lee, Ha Young Shin, Yeon Jung, Min Jung Kim, Nou Ri Lee, MiJu Shin, Farit A Khabirov, Lyudmila Averyanova, Natalya Babicheva, Eugenii Granatov, Sergey Kazarov, Timur Khaybullin, Alexander Rogozhin, Dmitry V Pokhabov, Vladislav Abramov, Anastasia Amelina, Yulia Nesteroca, Tatyana Bozhenkina, Aleksey N Boyko, Elena G Demyan, Inessa Khoroshilova, Mikhail Melnikov, Ekaterina V Popova, Svetlana N Sharanova, Sergey G Shchur, Denis V Sazonov, Larisa Babenko, Elena Bayandina, Asya Yarmoschuk, Victor A Baliazin, Elena Baliazina, Elena Budaeva, Irina Chernikova, Zoya Goncharova, Vladimir Krasnov, Marina Myatleva, Olga V. Rodionova, Iuliana Samulyzhko, Alla A. Timofeeva, Sabas Boyero Duran, Maria Mar Mendibe Bilbao, Irene Diaz Cuervo, Jose Maria Losada Domingo, Amaia Gonzalez Eizaguirre, Jose Eulalio Barcena Llona, Roberto Valverde Moyano, Carmen Bahamonde, Fernando Sanchez Lopez, Raquel Pinar Morales, Eduardo Agüera Morales, Carmen Bahamonde Roman, Juan Jose Ochoa Sepulveda, Maria del Carmen Blanco Valero, Nazaret Pelaez Viña, Cristina Conde Gavilan, Ana Maria Jover Sanchez, Sara Vila Bedmar, Nuria Gonzalez Garcia, Aida Orviz Garcia, Ines Gonzalez-Suarez, Elena Miñano Guillamon, Miguel Kawiorski, Elena Guerra Schulz, Alba Garcia Alonso, Francisco Jesus Lopez Perez, Marta Palacios Sarmiento, Guillermo Izquierdo Ayuso, Guillermo Navarro Mascarell, Cristina Paramo Camino, Asuncion Varas Garcia, Yaiza Montserrat Mendoza, Veronica Ines Vargas Muñoz, Patricia Torres Tonda, Ching-Piao Tsai, Jiu-Haw Yin, Mei-Jung Chen, Shan-Ni Li, Fei-Ti Wang, Suwat Srisuwannanukorn, Thanatat Boonmongkol, Duangporn Borisutbuathip, Duangkamol Singwicha, Krittika Siritanan, Chidchanoke Thearapati, Kwanmuang Sornda, Metha Apiwattanakul, Saharat Aungsumart, Narupat Suanprasert, Kaona Suksuchano, Nittaya Parkinsee, Kongkiat Kulkantrakorn, Praween Lolekha, Artit Potigumjon, Puchit Sukphulloprat, Dararat Suksasunee, Chankawee Komaratat, Sunattana Luangtong, Arkhom Arayawichanont, Phanpaphon Konpan, Nathapol Riablershirun, Thaddao Wiroteurairuang, Panadda Jantaweesirirat, Aslı Kurne, Irem Erkent, Ebru Bekircan Kurt, Ezgi Saylam, Yagmur Caliskan, Gulsah Orsel, Yahya Celik, Canan Celebi, Aslan Tekatas, Tugce Banbal, Gulsen Akman Demir, Burcu Altunrende, Zeliha Matur, Baris Topcular, Tules Elmas, Aysenur Gulo, Selin Ozdemir, Cansu Ozkoklesen, Mahinur Ozturk, Mertkan Yanik, Elif Yildirim, Melih Tutuncu, Ayse Altintas, Abdulsamet Cam, Ayse Deniz Elmali, Sabahattin Saip, Aksel Siva, Uygur Tanrıverdi, Ugur Uygunoglu, Sinem Caliskan, Pinar Gulo, Esra Kozig, Sakine Sakiz, Ihsan Sukru Sengun, Egemen Idiman, Rahmi Tumay Ala, Duygu Arslan, Utku Bulut, Yasemin Karakaptan, Derya Kaya, Zaur Mehdiyev, Bengu Balkan, Berfu Kuku, Mujgan Ozhun, Celal Tuga, Muzeyyen Ugur, Husnu Efendi, Sena Destan Bunul, Hakan Cavus, Yunus Emre Gorke, Ayse Kutlu, Seda Ozturk, Cansu Egilmez Sarikaya, Gulsah Becerikli, Cansu Semiz, Ozlem Tun, Sehriban Ayer, Musa Kazim Onar, Mehlika Berra Ozberk, Sedat Sen, Tugce Kirbas Cavdar, Adife Veske, Cavit Boz, Didem Altiparmak, Cigdem Ozen Aydin, Sibel Gazioglu, Duygu Bekircan, Anu Jacob, Heike Arndt, Liene Elsone, Shahd Hassan Mahmoud Hamid, Daniel Hugh Whittam, Martin Wilson, Imelda O'Brien, Maria Isabel da Silva Leite, Pedro Maria Rodriguez Cruz, Damian Robert Jenkins, George Tackley, Ana Cavey, Rosie Everett, Joy Hodder, Abigail Koelewyn, Ellen Mowry, Walter Royal, Robert Shin, Christopher Bever, Daniel Harrison, Horea Rus, Wei Zheng, Karen Callison, Kerry Naunton, Benjamin M Frishberg, Andrew M Blumenfeld, Andrew Inocelda, Kalyani Korabathina, Michael Lobatz, Melissa M Mortin, Irene J Oh, Jay H Rosenberg, Mark Sadoff, Gregory A Sahagian, Anchi Wang, Yasmin Camberos, Guadalupe Sanchez, Estela Soto, Jacqueline A Nicholas, Aaron Boster, Geoffrey Eubank, Katy Groezinger, Meghan Lauf, Annette F Okai, Rashedul Hasan, Chaouki Khoury, Victoria Stokes, Stacey Clardy, Melissa Cortez, John Greenlee, John Rose, Mateo Paz Soldan, Amanda Emett, Lawanda Esquibel, Lilly Fagatele, Ka-Ho Wong, James C Stevens, Thomas M Banas, Marlene C Bultemeyer, Andrea Haller, Natalie Manalo, Keri Aeschliman, Debi Kocks, Michael Racke, Aaron Lee Boster, Michelle Bowman, Jaime Imitola, Yasushi Kisanuki, Misty Green, Stephanie Scarberry, Sharon G Lynch, Heather S Anderson, Gary S Gronseth, Nancy E Hammond, Yasir N Jassam, Manoj K Mittal, Muhammed M Nashatizadeh, Nicholas Levine, Lisa Schmidt, Jill Sibley, Vonda Whitley, James Winkley, Timothy Coleman, Gregory Cooper, Stephanie Sheffield, Keri Turner, Dana Galloway, Robert S Tillett, Geeta A Ganesh, Brian M Plato, Tad D Seifert, Diana Godwin, Deborah Lockridge, Kottil W Rammohan, William A Sheremata, Silvia Delgado, Jose Gonzalez, Alexis Lizarraga, Janice Maldonado, Melissa Ortega, Leticia Tornes, Yanet Babcock, Osmara Cailam, Yesica Campos, Irlisse Couvertier, Bettina Daneri, Jeremy Deni, Jeffrey Hernandez, Tatiana Jaramillo, Tenita Morris, Daniel Nobel, Anjelis Oliveira, Reshma Richardson, Gloria Rodriguez, Ana Romero, Carlos Sandova, Ruta Sawant, Lissett Tueros, Eric S Zetka, Chao Zheng, Daniel H Jacobs, Constance Easterling, Jennifer Fairbank, Revathi Iyengar, Mark Klafter, Justin Lindquist, Ahmed H Sadek, Elizabeth Carmona Toro, Navin Verma, Brigith Patino Castro, Nadia Sukhraj-Singh, Joseph Berger, Eric Williamson, Salim Chahin, Dina Jacobs, Clyde Markowitz, Jessica Dobbins, Lauren Mace, Maria Martin, Ashley Pinckney, Amber Roberts, Islam Zaydan, Galen W Mitchell, Rock A Heyman, Ryan L Orie, Valerie R Suski, Kerry Oddis, Darlene Punjack, Eoin Flanagan, Avi Gadoth, Andrew McKeon, W Oliver Tobin, Anastasia Zekeridou, Katie Dunlay, Jessica Sagen, Jonathan L Carter, Bachir Estephan, Brent P Goodman, Charlene R Hoffman Snyder, Andrea Francone, Irene Galasky, Martha Thomas, Pavle Repovic, James Bowen, Angeli Mayadev, Peiqing Qian, Yuriko Courtney, Lauren Lennox, Robert Thomas Naismith, Anne Haney Cross, Emily Evans, Erin E Longbrake, Megan E Orchard, Gregory F Wu, Linda Heinrich, Susan Sommers, Faria Amjad, Erika Mitchell, Carlos Mora, Bethany Schreiber, Carlo Tornatore, Alexis Carlson, Sacha McCarthy, and Alexandria Oliver
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Adult ,medicine.medical_specialty ,Population ,Placebo ,Antibodies, Monoclonal, Humanized ,03 medical and health sciences ,Complement inhibitor ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,education ,Aquaporin 4 ,education.field_of_study ,Neuromyelitis optica ,business.industry ,Neuromyelitis Optica ,General Medicine ,Eculizumab ,medicine.disease ,Comorbidity ,ddc ,Neurology ,Concomitant ,Rituximab ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background Antibodies to the aquaporin-4 (AQP4) water channel in neuromyelitis optica spectrum disorder (NMOSD) are reported to trigger the complement cascade, which is implicated in astrocyte damage and subsequent neuronal injury. The PREVENT study demonstrated that the terminal complement inhibitor eculizumab reduces adjudicated relapse risk in patients with anti-AQP4 immunoglobulin G-positive (AQP4+) NMOSD. The objective of this analysis was to evaluate the efficacy of eculizumab in reducing relapse risk and its safety in AQP4+ NMOSD across clinically relevant subgroups in PREVENT. Methods In the randomized, double-blind, time-to-event, phase 3 PREVENT trial, 143 adults received eculizumab (maintenance dose, 1200 mg/2 weeks) or placebo (2:1), with stable-dose concomitant immunosuppressive therapy (IST) permitted (except rituximab and mitoxantrone). Post hoc analyses of relapses and adverse events were performed for prespecified and post hoc subgroups based on concomitant IST and prior rituximab use, demographic and disease characteristics, and autoimmune comorbidity. Results The significant reduction in relapse risk observed for eculizumab versus placebo in the overall PREVENT population was consistently maintained across subgroups based on concomitant IST and previous rituximab use, age, sex, region, race, time since clinical onset of NMOSD, historical annualized relapse rate, baseline Expanded Disability Status Scale score, and history of another autoimmune disorder. The serious infection rate was lower with eculizumab than placebo regardless of rituximab use in the previous year, concomitant IST use, or history of another autoimmune disorder. Conclusion Across a wide range of clinically relevant AQP4+ NMOSD patient subgroups in PREVENT, eculizumab therapy was consistently effective versus placebo in reducing relapse risk, with no apparent increase in serious infection rate. Trial registration NCT01892345 (ClinicalTrials.gov).
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- 2020
9. HyperCKemia in Guillain-Barré Syndrome
- Author
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Seok Jin Choi, Yoon-Ho Hong, Jun Soon Kim, Je Young Shin, and Jung-Joon Sung
- Subjects
Adult ,Male ,medicine.medical_specialty ,Guillain-Barre Syndrome ,Gastroenterology ,Young Adult ,Internal medicine ,Republic of Korea ,medicine ,Humans ,In patient ,Creatine Kinase ,Bulbar palsy ,Aged ,Retrospective Studies ,Aged, 80 and over ,Guillain-Barre syndrome ,biology ,business.industry ,Middle Aged ,medicine.disease ,Neurology ,biology.protein ,Serum creatine kinase ,Creatine kinase ,Female ,Neurology (clinical) ,medicine.symptom ,business - Abstract
The aim of the present study was to investigate the frequency and clinical features of Guillain-Barré syndrome (GBS) with hyperCKemia. We retrospectively identified 139 patients with GBS at 2 teaching hospitals in South Korea. We excluded patients with Miller-Fisher syndrome (n = 19), acute bulbar palsy (n = 3), and those whose serum creatine kinase (CK) levels were not measured (n = 45). Twelve of 72 patients (16.7%) had transient hyperCKemia, defined as serum CK ≥300 IU/L. The frequency of male sex and non-demyelinating electrodiagnostic features were higher in patients with hyperCKemia than those without. Transient hyperCKemia, occasionally seen in patients with GBS may be associated with the non-demyelinating subtype.
- Published
- 2020
10. High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
- Author
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Yoon-Ho Hong, Young Ju Suh, Je Young Shin, Jung-Joon Sung, Sung Min Kim, and Seok Jin Choi
- Subjects
Male ,medicine.medical_specialty ,Neutrophils ,lcsh:Medicine ,Cell Count ,Kaplan-Meier Estimate ,Gastroenterology ,Article ,Prognostic markers ,Internal medicine ,Cox proportional hazards regression ,medicine ,Humans ,In patient ,Lymphocytes ,Amyotrophic lateral sclerosis ,Neutrophil to lymphocyte ratio ,lcsh:Science ,Survival rate ,Short survival ,Multidisciplinary ,business.industry ,lcsh:R ,Hazard ratio ,Amyotrophic Lateral Sclerosis ,Middle Aged ,medicine.disease ,lcsh:Q ,Female ,business ,Median survival - Abstract
The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p
- Published
- 2020
11. Effect of Physical Activity on the Progression of Alzheimer’s Disease: The Clinical Research Center for Dementia of South Korea Study
- Author
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Moon Ho Park, Kyung Won Park, Bora Yoon, Yang Ki Minn, Youn Kyung Oh, Jong Hun Kim, Eun-Joo Kim, Seok Jin Choi, Seong Hye Choi, Young Ju Suh, Soo Jin Yoon, Jee Hyang Jeong, and Young Chul Youn
- Subjects
Male ,medicine.medical_specialty ,Activities of daily living ,Physical activity ,Disease ,Neuropsychological Tests ,Lower risk ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Internal medicine ,Republic of Korea ,mental disorders ,medicine ,Humans ,Dementia ,Registries ,030212 general & internal medicine ,Exercise ,Aged ,Aged, 80 and over ,Academic Medical Centers ,business.industry ,General Neuroscience ,Neuropsychology ,General Medicine ,medicine.disease ,Rate of increase ,Psychiatry and Mental health ,Clinical Psychology ,Clinical research ,Disease Progression ,Female ,Geriatrics and Gerontology ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
There is a lack of research on the effects of physical activity (PA) on the progression of Alzheimer's disease (AD).We investigated whether PA is associated with progression of dementia and mortality in AD.In the present study, 934 patients with mild-to-moderate AD were included. PA was evaluated using a questionnaire written by the caregiver. The outcome measures were the Clinical Dementia Rating-Sum of Boxes (CDR-SB), Seoul-Instrumental Activities of Daily Living (S-IADL), Caregiver-Administered Neuropsychiatric Inventory (CGA-NPI), a global composite score of neuropsychological subtests, and mortality. They were evaluated annually and received a maximum of three follow-up examinations.Between-group differences compared with the no PA group in the change of CDR-SB scores were -0.431 (95% CI = -0.824∼-0.039; p = 0.031) for the moderate PA group (150-750 minutes per week of moderate intensity PA), and -1.148 (-1.656∼-0.639; p 0.001) for the high PA group (750 minutes per week). As PA increased, there was a significant trend to slow the rate of increase in the CDR-SB, S-IADL, and CGA-NPI scores. The patients with ≥150 minutes per week for each of non-recreational and recreational PAs had a lower risk of mortality compared to those with150 minutes per week for each of the PAs (hazard ratio 0.22, 95% CI = 0.05∼0.88; p = 0.033).More PA is associated with slower progression of dementia severity, functional decline, and abnormal behavior, and with a lower risk of mortality in AD.
- Published
- 2018
12. Takotsubo cardiomyopathy in amyotrophic lateral sclerosis
- Author
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Sung Yeon Sohn, Je Young Shin, Yoon-Ho Hong, Jung-Joon Sung, Chan Soon Park, Seok Jin Choi, and Byung Nam Yoon
- Subjects
Inotrope ,Acute coronary syndrome ,medicine.medical_specialty ,Exacerbation ,business.industry ,Chest discomfort ,Cardiomyopathy ,Disease ,030204 cardiovascular system & hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Intravenous fluid ,Neurology ,Internal medicine ,medicine ,Cardiology ,Neurology (clinical) ,Amyotrophic lateral sclerosis ,business ,030217 neurology & neurosurgery - Abstract
Objective To investigate the frequency, features, and prognosis of takotsubo cardiomyopathy (TTC) in patients with amyotrophic lateral sclerosis (ALS). Methods We reviewed detailed clinical, laboratory, and cardiovascular data from 64 ALS patients (38 men and 26 women) who underwent echocardiographic evaluation for various reasons at a single referral center between January 2011 and December 2015. Results TTC was diagnosed in 9 ALS patients (4 men and 5 women). Mean age was 61.3 years (range 55–71 years), and median disease duration was 51.5 months (range 18–134 months). All patients were bulbar or cervical onset, and were at advanced stages of ALS when TTC was diagnosed. Acute exacerbation of dyspnea was an invariable presentation, and chest discomfort mimicking acute coronary syndrome was present in 2 patients. Six patients had significant hypotension requiring intravenous fluid challenge and inotropic support. Three patients showed altered mentality, and 2 of them suffered cardiopulmonary arrest. Conclusions TTC should be suspected in ALS patients presenting with acute exacerbation of dyspnea and chest discomfort, particularly at advanced stages of the disease. This study highlights the need for proper evaluation and management of cardiac dysfunction in ALS.
- Published
- 2017
13. The Relationship between Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease and the Rubella Virus
- Author
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Dan A Oh, Sung Min Kim, Seok Jin Choi, and Woochang Chun
- Subjects
0301 basic medicine ,biology ,business.industry ,Rubella virus ,Disease ,medicine.disease_cause ,Virology ,Myelin oligodendrocyte glycoprotein ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Neurology ,biology.protein ,medicine ,Neurology (clinical) ,Antibody ,business ,Letter to the Editor ,030217 neurology & neurosurgery - Published
- 2018
14. Spinobulbar muscular atrophy combined with atypical hereditary neuropathy with liability to pressure palsy
- Author
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Jung-Joon Sung, So Hyun Ahn, Seolhee Baek, Kyomin Choi, Jun Soon Kim, Sung Min Kim, Yoon-Ho Hong, Je Young Shin, and Seok Jin Choi
- Subjects
Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Weakness ,Fasciculation ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Physiology (medical) ,Peripheral myelin protein 22 ,Pressure ,medicine ,Humans ,Paralysis ,Motor Neuron Disease ,Sequence Deletion ,Genetic testing ,Dysesthesia ,Palsy ,medicine.diagnostic_test ,business.industry ,Electrodiagnosis ,Peripheral Nervous System Diseases ,General Medicine ,Middle Aged ,medicine.disease ,Muscular Disorders, Atrophic ,030104 developmental biology ,Neurology ,Receptors, Androgen ,Disease Progression ,Surgery ,Neurology (clinical) ,medicine.symptom ,business ,Polyneuropathy ,Myelin Proteins ,030217 neurology & neurosurgery - Abstract
Spinobulbar muscular atrophy (SBMA) is an X-linked recessive disease, presenting motor weakness and wasting of facial, bulbar and limb muscles. Hereditary neuropathy with liability to pressure palsy (HNPP) is autosomal dominant disorder characterized by recurrent neuropathies at common entrapment sites. We report a case of co-existence of SBMA and atypical HNPP with genetic confirmation of CAG expansion in the androgen receptor (AR) gene and deletion of the peripheral myelin protein 22 (PMP22) gene. A 62-year-old man presented with progressive muscle weakness, fasciculations in upper and lower limbs and dysesthesia predominantly in the distal regions. No family members, including his children, experienced similar symptoms. The electrodiagnostic examination was compatible with demyelinating sensorimotor polyneuropathy. Simultaneous hereditary polyneuropathy and motor neuron disease were suspected and relevant genetic testing was confirmed HNPP and SBMA. This case presented with 2 rare genetic neuromuscular disorders and the atypical HNPP phenotype. This case highlight the importance of detailed patient histories, as well as neurological and electrophysiological examinations for diagnosis of atypical and combination of rare genetic disorders.
- Published
- 2018
15. Rebound of relapses after discontinuation of rituximab in a patient with MOG-IgG1 positive highly relapsing optic neuritis: a case report
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Jung-Joon Sung, Sung Min Kim, Haeng Jin Lee, Seok Jin Choi, Seong Joon Kim, and Boram Kim
- Subjects
Male ,0301 basic medicine ,Pediatrics ,medicine.medical_specialty ,Optic Neuritis ,MOG-IgG1 ,Case Report ,lcsh:RC346-429 ,Myelin oligodendrocyte glycoprotein ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,immune system diseases ,Humans ,Immunologic Factors ,Medicine ,Optic neuritis ,lcsh:Neurology. Diseases of the nervous system ,Autoantibodies ,Neuromyelitis optica ,biology ,business.industry ,Multiple sclerosis ,General Medicine ,Middle Aged ,medicine.disease ,Highly relapsing ,Discontinuation ,Regimen ,030104 developmental biology ,Immunoglobulin G ,Chronic Disease ,biology.protein ,Prednisolone ,Myelin-Oligodendrocyte Glycoprotein ,Rituximab ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Background Myelin oligodendrocyte glycoprotein immunoglobulin G1 (MOG-IgG1)-associated disease is suggested as a separate disease entity distinct from multiple sclerosis and neuromyelitis optica spectrum disorder. Nonetheless, the optimal treatment regimen for preventing relapses in MOG-IgG1-associated disease remains unclear. Case presentation We describe the case of a 45-year-old man with MOG-IgG1-positive highly relapsing optic neuritis who had experienced 5 attacks over 21 months and had monocular blindness despite prednisolone and azathioprine therapy. He began treatment with rituximab, which reduced the rate of relapse markedly. Following discontinuation of rituximab, however, the patient experienced two successive optic neuritis attacks 2 and 4 months after B-lymphocyte restoration. Conclusions Highly relapsing MOG-IgG1-associated disease can be prevented with rituximab even when the MOG-IgG1 titers are relatively stationary. Discontinuation of rituximab and restoration of B-lymphocytes may be associated with the rebound of disease activity.
- Published
- 2018
16. CT Follow-Up of Postoperative Bronchopleural Fistula: Risk Factors for Progression to Chronic Complicated Infection
- Author
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Ji-Yeon, Han, Ki-Nam, Lee, Yoo Sang, Yoon, Jihyun, Lee, Hongyeul, Lee, Seok Jin, Choi, Hye Jung, Choo, Jin Wook, Baek, Young Jin, Heo, Gi Won, Shin, Jinyoung, Park, and Dasom, Kim
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,lobectomy ,medicine.medical_specialty ,business.industry ,lcsh:R895-920 ,Fistula ,medicine.medical_treatment ,medicine.disease ,Surgery ,Pneumonectomy ,medicine ,fistula ,Radiology, Nuclear Medicine and imaging ,business ,pneumonectomy - Abstract
Purpose We evaluated the risk factors for progression to chronic complicated bronchopleural fistula (BPF) after pulmonary resection using follow-up CT. Materials and Methods We retrospectively reviewed 45 cases with BPF that had undergone pulmonary resection during 2010-2018. We compared the clinical and radiological characteristics of those with complicated BPF (n = 24) and those without complicated (sterilized) BPF (n = 21). The clinical and radiological risk factors for progression to chronic complicated BPF were examined by logistic regression analysis. Results The thickness of the pleural cavity wall (p = 0.022), the size of the pleural cavity (p = 0.029), and the size increase of BPF on follow-up (p = 0.012) were significantly different between the two groups. The risk factors for progression to chronic complicated BPF were age > 70 years (odds ratio, 6.43; 95% confidence interval, 1.2–33.7), the thickness of the cavity wall > 5 mm (odds ratio, 52.5; 95% confidence interval, 5.1–545.4), and an increase in the size of the pleural cavity on follow-up CT (odds ratio, 12.5; 95% confidence interval, 2.1–73.5), only in the univariate analysis. Conclusion The risk factors for progression to chronic complicated BPF can be evaluated using follow-up CT.
- Published
- 2021
17. Fatal Encephalopathy Caused by a Urea Cycle Disorder
- Author
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Nam Hee Kim, Hee Sup Kim, Jung Hwan Lee, Soo Hyun Park, and Seok Jin Choi
- Subjects
medicine.medical_specialty ,Pediatrics ,Neurology ,Urea cycle disorder ,business.industry ,Encephalopathy ,MEDLINE ,medicine.disease ,Text mining ,medicine ,Neurology (clinical) ,business ,Letter to the Editor - Published
- 2021
18. Proximal Median Neuropathy Caused by Axillary Brachial Plexus Block
- Author
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Dong Gun Kim, Seok-Jin Choi, and Kyung Seok Park
- Subjects
medicine.medical_specialty ,Proximal Median Neuropathy ,business.industry ,Axillary brachial plexus block ,Medicine ,business ,Surgery - Published
- 2016
19. Pearls & Oy-sters: Asymmetric meningeal involvement is a common feature of rheumatoid meningitis
- Author
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SangYun Kim, Gheeyoung Choe, Jung Ho Han, Jin Ah Kim, Young Ho Park, and Seok Jin Choi
- Subjects
musculoskeletal diseases ,Pathology ,medicine.medical_specialty ,Arthritis ,Arthritis, Rheumatoid ,Diagnosis, Differential ,03 medical and health sciences ,Meninges ,0302 clinical medicine ,Biopsy ,Humans ,Medicine ,Meningitis ,Aged ,030203 arthritis & rheumatology ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Dermatology ,eye diseases ,humanities ,Feature (computer vision) ,Rheumatoid arthritis ,Female ,Neurology (clinical) ,business ,Complication ,030217 neurology & neurosurgery - Abstract
Rheumatoid meningitis is a rare complication of rheumatoid arthritis that requires a meningeal biopsy for diagnosis. The authors thank Drs. YoonJin Kwak and Kyu Sang Lee of the Department of Pathology at Seoul National University Bundang Hospital for comments and technical assistance in preparing the figures.
- Published
- 2017
20. Electrodiagnostic data-driven clustering identifies a prognostically different subgroup of patients with chronic inflammatory demyelinating polyneuropathy
- Author
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Je Young Shin, Yoon-Ho Hong, Jung-Joon Sung, So Hyun Ahn, Seok Jin Choi, Seolhee Baek, and Kee Hong Park
- Subjects
Hierarchical agglomerative clustering ,Adult ,Male ,Treatment response ,medicine.medical_specialty ,Chronic inflammatory demyelinating polyneuropathy ,02 engineering and technology ,Logistic regression ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,0202 electrical engineering, electronic engineering, information engineering ,Medicine ,Cluster Analysis ,Humans ,Cluster analysis ,Aged ,Aged, 80 and over ,business.industry ,Electromyography ,Electrodiagnosis ,Stepwise regression ,Middle Aged ,medicine.disease ,Prognosis ,Compound muscle action potential ,Psychiatry and Mental health ,Polyradiculoneuropathy, Chronic Inflammatory Demyelinating ,020201 artificial intelligence & image processing ,Surgery ,Female ,Neurology (clinical) ,business ,Polyneuropathy ,030217 neurology & neurosurgery ,Algorithms - Abstract
ObjectiveThis study aimed to explore the correlations between electrodiagnostic (EDX) features in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and to investigate whether EDX data-driven clustering can identify a distinct subgroup regarding clinical phenotype and treatment response.MethodsWe reviewed clinical and EDX data of 56 patients with definite CIDP fulfilling the 2010 European Federation of Neurological Societies and Peripheral Nerve Society criteria at two teaching hospitals. A hierarchical agglomerative clustering algorithm with complete linkage was used to partition the patients into subgroups with similar EDX features. A stepwise logistic regression analysis was performed to evaluate predictors of the long-term outcome.ResultsEDX data-driven clustering partitioned the patients into two clusters, identifying a distinct subgroup characterised by coexistence of prominent conduction slowing and markedly reduced distally evoked compound muscle action potential (CMAP) amplitudes. This cluster of patients was significantly over-represented by an atypical subtype (distal acquired demyelinating symmetric polyneuropathy) compared with the other cluster (70% vs 26.1%, p=0.042). Furthermore, patients in this cluster invariably showed favourable long-term treatment outcome (100% vs 63%, p=0.023). In logistic regression analyses, the initial disability (OR 6.1, 95% CI 2.4 to 25.4), F-wave latency (OR 0.93, 95% CI 0.86 to 0.98) and distal CMAP duration (OR 0.96, 95% CI 0.91 to 0.99) were significant predictors of the poor long-term outcome.ConclusionOur results show that EDX data-driven clustering could differentiate a pattern of EDX features with prognostic implication in patients with CIDP. Reduced distally evoked CMAPs may not necessarily predict poor responses to treatment, and active treatment is warranted when prominent slowing of conduction is accompanied in the distal segments.
- Published
- 2018
21. Correlation of microbiological yield with radiographic activity on chest computed tomography in cases of suspected pulmonary tuberculosis
- Author
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Yousang Ko, Su Jin Hong, Seok Jin Choi, Changhwan Kim, So Young Park, Jeong Hwan Shin, Jin Young Jeong, Ho Young Lee, and Yong Bum Park
- Subjects
Male ,Bacterial Diseases ,Thorax ,Etiology ,Radiography ,lcsh:Medicine ,Pathology and Laboratory Medicine ,Bronchoalveolar Lavage ,Diagnostic Radiology ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Medicine and Health Sciences ,lcsh:Science ,Lung ,Respiratory Tract Infections ,Tomography ,Multidisciplinary ,integumentary system ,Radiology and Imaging ,Middle Aged ,Actinobacteria ,Infectious Diseases ,medicine.anatomical_structure ,Tuberculosis Diagnosis and Management ,Female ,Radiology ,Anatomy ,Research Article ,Adult ,medicine.medical_specialty ,Histology ,Tuberculosis ,Imaging Techniques ,Neuroimaging ,Research and Analysis Methods ,Sensitivity and Specificity ,03 medical and health sciences ,Signs and Symptoms ,Diagnostic Medicine ,Bronchoscopy ,medicine ,Humans ,Tuberculosis, Pulmonary ,Aged ,Retrospective Studies ,Bacteriological Techniques ,Bacteria ,business.industry ,lcsh:R ,Organisms ,Bacterial pneumonia ,Biology and Life Sciences ,Retrospective cohort study ,Mycobacterium tuberculosis ,Tropical Diseases ,medicine.disease ,Computed Axial Tomography ,Pneumonia ,030228 respiratory system ,Lesions ,lcsh:Q ,Tomography, X-Ray Computed ,business ,Neuroscience - Abstract
Background Little is known about the correlation between microbiological yield and radiographic activity, on chest computed tomography (CT), in suspected pulmonary tuberculosis (PTB) cases, despite CT being widely used, clinically. Methods We used multicenter retrospective data, obtained from medical records, focusing on the diagnostic performance for definite PTB. We categorized patients into four groups, by radiographic activity: definitely active, probably active, indeterminate activity, and probably inactive. Results Of the 650 patients included, 316 had culture-confirmed PTB; 190 (29.2%), 323 (49.7%), 70 (10.8%), and 67 (10.3%) were classified into the definitely active, probably active, indeterminate activity, and probably inactive groups, respectively. The corresponding observed culture rates for CT radiographic activity were 61.6%, 60.7%, 4.3% and 0%, respectively. When not only culture rates but TB-PCR and histological results were taken into consideration as definite PTB, it showed 66.6%, 67.2%, 14.3%, and 0% of each CT radiographic activity, respectively. Regarding the diagnostic performance for definite PTB, radiographic activity displayed high sensitivity (97.1%, 95% confidence interval (CI), 94.6-98.5) and negative predictive values (92.7%, 95% CI, 86.6-96.2), considered definitely and probably active PTB. Apart from PTB, other etiologies, according to radiographic activity, were predominantly respiratory infections such as bacterial pneumonia and non-tuberculous mycobacterial infection. Conclusions Radiographic activity showed good diagnostic performance, and can be used easily in clinical practice. However, clinicians should consider other possibilities, because radiologic images do not confirm microbiological PTB.
- Published
- 2018
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22. False Positive Radioiodinated Metaiodobenzylguanidine (123I-MIBG) Uptake in Undifferentiated Adrenal Malignant Tumor
- Author
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Seok Jun Moon, Seok Mo Lee, Min Jeong Kwon, Tae Kyoon Kim, Jeong Hyun Park, Soo Jin Jung, Yun Mi Kim, Soon Hee Lee, Hye Rim Kang, Hee Soo Jung, and Seok Jin Choi
- Subjects
Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,123i mibg ,business.industry ,Lymph node biopsy ,Case Report ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Scintigraphy ,medicine.disease ,lcsh:RC254-282 ,Epigastric pain ,Metastatic carcinoma ,Pheochromocytoma ,Oncology ,Medicine ,Abdominal computed tomography ,business ,Hormone - Abstract
123I-Metaiodobenzylguanidine (123I-MIBG) scintigraphy is a widely used functional imaging tool with a high degree of sensitivity and specificity in diagnosis of pheochromocytoma. However, rare cases of false positive reactions have been reported. A 67-year-old male patient was admitted with epigastric pain. Abdominal computed tomography (CT) revealed a heterogeneous left adrenal mass 6 cm in diameter; following hormone testing,123I-MIBG scintigraphy was performed to determine the presence of pheochromocytoma, which confirmed eccentric uptake by a large left adrenal gland mass. Chest CT and PET-CT confirmed metastatic lymphadenopathy; therefore, endobronchial ultrasound transbronchial needle aspiration was performed. Metastatic carcinoma of unknown origin was suspected from a lymph node biopsy, and surgical resection was performed for definitive diagnosis and correction of excess hormonal secretion. A final diagnosis of undifferentiated adrenal malignant tumor was rendered, instead of histologically malignant pheochromocytoma, despite the uptake of123I-MIBG demonstrated by scintigraphy.
- Published
- 2015
23. Comparison of the trauma and injury severity score and modified early warning score with rapid lactate level (the ViEWS-L score) in blunt trauma patients
- Author
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Seok Jin Choi, Boyoung Park, Jae Baek Lee, Taeoh Jeong, Jaechol Yoon, Sion Jo, and Young Ho Jin
- Subjects
Male ,medicine.medical_specialty ,Poison control ,Wounds, Nonpenetrating ,Risk Assessment ,Statistics, Nonparametric ,Cohort Studies ,Tertiary Care Centers ,Injury Severity Score ,Predictive Value of Tests ,Interquartile range ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Hospital Mortality ,APACHE ,Aged ,Retrospective Studies ,Academic Medical Centers ,Chi-Square Distribution ,Receiver operating characteristic ,business.industry ,Emergency department ,Middle Aged ,Revised Trauma Score ,Prognosis ,Early warning score ,Surgery ,Survival Rate ,Treatment Outcome ,ROC Curve ,Blunt trauma ,Lactates ,Emergency Medicine ,Wounds and Injuries ,Female ,Emergency Service, Hospital ,business ,Biomarkers - Abstract
OBJECTIVE: The aim of this study was to compare the predictive value of the VitalPAC Early Warning Score-lactate (ViEWS-L) score with that of the trauma and injury severity score (TRISS), which is a pre-existing risk scoring system used in trauma patients. METHODS: The patients were blunt trauma victims admitted consecutively to the study hospital between 1 April 2010 and 31 March 2011, who were 15 years or older and had an injury severity score of 9 or higher. The lactate level, the ViEWS and revised trauma score upon arrival at the emergency department, and the injury severity score and TRISS were evaluated. The ViEWS-L score was calculated according to the formula: ViEWS-L=ViEWS+lactate (mmol/l). The ability to predict mortality was assessed by area under the receiver operating characteristic curve (AUC) analysis and calibration analysis. RESULTS: A total of 299 patients were available for analysis, of whom 33 died (11.0%). The median ViEWS-L score was 3.7 (interquartile range:1.8-6.4) and the median TRISS was 96.8 (interquartile range: 93.4-98.6). The ViEWS-L score was better than TRISS at predicting hospital mortality (AUC, 0.838; 95% confidence interval, 0.771-0.906 vs. AUC, 0.734; 95% confidence interval, 0.635-0.833, P=0.031). Calibration of the ViEWS-L score (χ=11.13, P=0.194) was good but that of TRISS was not (χ=16.97, P=0.018). CONCLUSION: The prognostic value of the ViEWS-L score in terms of discrimination was better than that of TRISS in the blunt trauma patients admitted to the emergency department with an injury severity score of 9 or higher, and the ViEWS-L score showed good calibration. Language: en
- Published
- 2014
24. Multidrug-Resistant Tuberculosis Presenting as Miliary Tuberculosis without Immune Suppression: A Case Diagnosed Rapidly with the Genotypic Line Probe Assay Method
- Author
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Seok Jin Choi, Ho Young Lee, Yousang Ko, Jeong Hwan Shin, Junwhi Song, Hyun Kyung Lee, Youngmin Lee, Mi Yeong Kim, and Young Seok Lee
- Subjects
Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Miliary tuberculosis ,Pathology ,Tuberculosis ,business.industry ,Tuberculosis, Miliary ,Isoniazid ,Molecular Probe Techniques ,Case Report ,medicine.disease ,Multiple drug resistance ,Infectious Diseases ,Streptomycin ,Internal medicine ,Tuberculosis, Multidrug-Resistant ,medicine ,business ,Pathogen ,Rifampicin ,Ethambutol ,medicine.drug - Abstract
Miliary tuberculosis (TB) is a rare extrapulmonary form of TB, and there have been only two reports of miliary TB associated with infection with multidrug-resistant (MDR)-TB pathogen in an immunocompetent host. A 32-year-old woman was referred to our hospital because of abnormal findings on chest X-ray. The patient was diagnosed with MDR-TB by a line probe assay and was administered proper antituberculous drugs. After eight weeks, a solid-media drug sensitivity test revealed that the pathogen was resistant to ethambutol and streptomycin in addition to isoniazid and rifampicin. The patient was then treated with effective antituberculous drugs without delay after diagnosis of MDR-TB. To the best of our knowledge, this is the first case of miliary TB caused by MDR-TB pathogen in Korea.
- Published
- 2014
25. Best abstract award runner-up. Comparison of muscle motor evoked potential changes between cervical and thoracic ossification of the posterior longitudinal ligament surgery
- Author
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Seok-Jin Choi, Sung Un Kim, Seong Rae Jo, Sung Min Kim, and Kyung Seok Park
- Subjects
medicine.medical_specialty ,Neurology ,business.industry ,Physiology (medical) ,medicine ,Ossification of the posterior longitudinal ligament ,Neurology (clinical) ,Evoked potential ,business ,Sensory Systems ,Surgery - Published
- 2019
26. Intraarticular Local Anesthesia: Can It Reduce Pain Related to MR or CT Arthrography of the Shoulder?
- Author
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Hye Jung Choo, Seok Jin Choi, Dong Wook Kim, In Sook Lee, and Sun Joo Lee
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Visual analogue scale ,medicine.drug_class ,Iohexol ,Mepivacaine ,Contrast Media ,Injections, Intra-Articular ,Shoulder Pain ,Pain level ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Local anesthesia ,Verbal Rating Scale ,Prospective Studies ,Anesthetics, Local ,Arthrography ,Aged ,Pain Measurement ,Analysis of Variance ,Pain score ,business.industry ,Local anesthetic ,General Medicine ,Middle Aged ,Magnetic Resonance Imaging ,Surgery ,Anesthesia ,Female ,Ct arthrography ,Shoulder Injuries ,Tomography, X-Ray Computed ,business ,Anesthesia, Local ,medicine.drug - Abstract
The objective of this study was to prospectively evaluate whether intraarticular anesthesia can reduce pain after MR or CT arthrography of the shoulder.This study included 120 patients who underwent CT or MR arthrography of the shoulder. The patients were randomized into two groups: the study group (n = 60), each administered an intraarticular injection of the contrast agent mixed with a local anesthetic (2% mepivacaine); and the control group (n = 60), each injected with the contrast agent only. Each patient's pain level was assessed at five phases-baseline and immediately, 2 hours, 1 day, and 2 days after injection-by using a visual analog scale or a verbal rating scale. The net pain score at each phase was also calculated. The pain course and net pain score were compared between study and control groups by repeated-measures analysis of variance. After the patients were divided into subgroups according to patient- or procedure-related factors, the efficacy of the intraarticular local anesthetic in each subgroup was evaluated.The pain course showed a quadratic trend and was not significantly different between study and control groups. The net pain score also was not significantly different between the two groups. No subgroup showed a significantly different efficacy of the intraarticular local anesthetic between the two groups.Intraarticular local anesthesia did not reduce arthrography-related pain.
- Published
- 2013
27. Concurrent Diagnosis of Pulmonary Metastasis of Malignant Mixed Müllerian Tumor and Small Cell Lung Cancer
- Author
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Seok Jin Choi, Hyun Kyung Lee, Seung Heon Lee, Young Jin Lee, Eun Joo Jung, Youngmin Lee, Bomi Kim, and Dae Hoon Jeong
- Subjects
Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Femur fracture ,Chemotherapy ,Lung ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Mixed Tumor, Müllerian ,Cancer ,Case Report ,respiratory system ,medicine.disease ,Malignancy ,Small Cell Lung Carcinoma ,respiratory tract diseases ,Infectious Diseases ,medicine.anatomical_structure ,Biopsy ,medicine ,Lung cancer ,business - Abstract
A patient who has multiple lung masses with a history of malignancy in organs other than the lung is more likely to be diagnosed with metastatic rather than primary lung cancer. Rarely, metastatic cancer can coexist with primary. We experienced a case of concurrent diagnosis of primary small cell lung cancer and pulmonary metastasis of uterine malignant mixed Mullerian tumor (MMMT). The patient was a 52-year-old female with femur fracture and multiple lung masses with a history of an operation for uterine MMMT. The small cell lung cancer was diagnosed by bronchoscopic biopsy. The central lung mass decreased after chemotherapy for small cell lung cancer but multiple peripheral masses increased. A percutaneous biopsy for one of peripheral masses revealed metastatic uterine MMMT. We suggest that we have to consider the possible presence of concomitant malignancies of different origins in one organ especially with patients who had a history of malignancy in another organ.
- Published
- 2012
28. Genetic Alterations in Gastric Carcinomas and Adjacent Mucosa Detected by Comparative Genomic Hybridization (CGH)
- Author
-
Ja Young Koo, Moo In Park, Kyu Jong Kim, Jee Young Lee, Dong Wan Kim, Seun Ja Park, Sun Hoe Koo, and Seok Jin Choi
- Subjects
Stomach neoplasm ,Cancer Research ,Candidate gene ,Oncology ,business.industry ,Medicine ,Gastric carcinogenesis ,business ,Molecular biology ,Metaphase ,Virtual karyotype ,Comparative genomic hybridization - Abstract
Purpose Comparative genomic hybridization (CGH) was used to detect any amplified or deleted chromosomal regions in tumors by mapping their locations on normal metaphase chromosomes. Meterials and methods Twenty-six gastric carcinomas and their adjacent mucosa were screened for chromosomal aberrations using CGH. Results All carcinomas had chromosomal aberrations, and chromosomal material was more likely to be gained than lost. Ten out of 26 adjacent mucosa had chromosomal aberrations, and a gain was less frequently observed than a tumor (1.6/2.6). The most common gains were detected on 13q (58.3%), 8q (30.8%), 6q (27.0%), and 20p (19.2%), while the most frequent losses were detected on 17p (38.5%) and 16q (7.2%). The most commonchromosomal aberrations in the adjacent mucosa were a gain of 13q (11.5%) and a loss of 17q (11.5%). The tumors had more chromosomal gains of 2q, 3q, and 13q and more losses of 17p and 16q than the adjacent mucosa. Conclusion S: The most common gain in the tumors was detected on 13q, 8q, 6q, and 20p, and the most frequent loss was on 17p and 16q. While CGH may be useful in predicting the prognosis or therapeutic decision of gastric carcinomas, further study of several candidate genes, such as DP1, FLT1, c-myb, AIB1, BTAK, is needed to clarify gastric carcinogenesis and its progression.
- Published
- 2015
29. Response to the letter to the editor regarding an article, 'Takotsubo cardiomyopathy in amyotrophic lateral sclerosis'
- Author
-
Jung-Joon Sung, Yoon-Ho Hong, Je Young Shin, Chan Soon Park, Byung Nam Yoon, Seok Jin Choi, and Sung Yeon Sohn
- Subjects
medicine.medical_specialty ,Letter to the editor ,business.industry ,Amyotrophic Lateral Sclerosis ,Cardiomyopathy ,030204 cardiovascular system & hematology ,medicine.disease ,Electrocardiography ,03 medical and health sciences ,0302 clinical medicine ,Neurology ,Takotsubo Cardiomyopathy ,Internal medicine ,medicine ,Cardiology ,Humans ,Neurology (clinical) ,Amyotrophic lateral sclerosis ,business ,030217 neurology & neurosurgery - Published
- 2017
30. Effects of silicone surfactant on the cell size and thermal conductivity of rigid polyurethane foams by environmentally friendly blowing agents
- Author
-
Youn Hee Kim, Ji Mun Kim, Woo Nyon Kim, Seok Jin Choi, Mi Sun Han, Heon Lee, and Joon Yong Sung
- Subjects
Materials science ,Polymers and Plastics ,business.industry ,General Chemical Engineering ,Organic Chemistry ,technology, industry, and agriculture ,equipment and supplies ,complex mixtures ,chemistry.chemical_compound ,Thermal conductivity ,Silicone ,Pulmonary surfactant ,Distilled water ,chemistry ,Polymer ratio ,Blowing agent ,Thermal insulation ,Materials Chemistry ,Composite material ,business ,Polyurethane - Abstract
Rigid polyurethane foams (PUF)s were synthesized with environmentally friendly blowing agents such as a cyclopentane/distilled water (10.0/1.0, pphp) mixture and distilled water only for four different silicone surfactants having different silicone/polyether ratios. An attempt was made to reduce the thermal conductivities of the PUF samples by varying the concentration and the silicone/polyether ratio of the various silicone surfactants. The scanning electron microscopy (SEM) results indicated an optimum concentration of the silicone surfactant of about 1.5 to 2.5 phpp for various surfactants to reduce the cell size and lower the thermal conductivity. The silicone surfactant having a higher silicone/polymer ratio showed a smaller cell size and, therefore, demonstrated the lower thermal conductivity of the PUF samples. From the relation between the thermal conductivity and the cell size of the PUF samples, the smaller cell size improved the thermal insulation property of the rigid PUF for both the PUF samples blown by the cyclopentane/distilled water (10.0/1.0, pphp) mixture and distilled water only. If the blowing agent is fixed, then the cell size is an important factor to decrease the thermal conductivity of the PUF samples. These results indicated that rigid PUF samples having lower thermal conductivity can be obtained by choosing a silicone surfactant containing a higher silicone/polyether ratio, as well as an optimum content of the surfactant.
- Published
- 2009
31. Crisscross-Configured Dual Stent Placement for Trisectoral Drainage in Patients with Advanced Biliary Hilar Malignancies
- Author
-
Yeong-Mi Park, Jae Ik Bae, Auh Whan Park, Seok Jin Choi, Seon-Joo Lee, Hyoung Pil Kim, and Jeong Hee Yoon
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Prosthesis Design ,Stent patency ,Malignancy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Clinical efficacy ,Aged ,Aged, 80 and over ,Common bile duct ,business.industry ,Liver Neoplasms ,Stent ,Middle Aged ,equipment and supplies ,medicine.disease ,Surgery ,Radiography ,Stent placement ,Treatment Outcome ,medicine.anatomical_structure ,Bile Duct Neoplasms ,Drainage ,Female ,Stents ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Left Hepatic Duct - Abstract
Purpose To evaluate technical success and clinical efficacy of crisscross-configured dual biliary stent implantation in patients with a biliary hilar tumor extending beyond the segmental ducts. Materials and Methods Between January 2002 and December 2006, two metallic stents were placed crossing each other in a hepatic hilum in 42 patients. One stent was placed between one right sectoral duct and the left hepatic duct and the other was placed between another right sectoral duct and the common bile duct. The patients ranged in age from 36 to 83 years (mean, 63.3 y) and included 26 men and 16 women. Technical success, clinical success, complications, and long-term results were analyzed by retrospective review. Results Stent placement was performed through two right accesses ( n = 30), one right and one left access ( n = 3), or two right accesses and one left access ( n = 6). Successful "trisectoral" drainage was obtained with two stents in 41 patients (98%). In one case of initial technical failure, an additional stent was needed to connect the two previously placed stents. Clinical success was obtained in 34 of the remaining 36 patients (92%). No procedure-related major complication was observed. The median primary stent patency time was 187 days and the median patient survival time was 247 days. Conclusions Crisscross-configured dual stent implantation is a feasible, safe, and effective method to maximize hepatic drainage with a minimal number of stents in patients with advanced biliary hilar malignancy.
- Published
- 2008
32. Effects of organoclay on the thermal insulating properties of rigid polyurethane poams blown by environmentally friendly blowing agents
- Author
-
Woo Nyon Kim, Seok Jin Choi, Kyu Tae Bang, Ji Mun Kim, Mi Sun Han, and Youn Hee Kim
- Subjects
Nanocomposite ,Materials science ,Polymers and Plastics ,business.industry ,General Chemical Engineering ,Organic Chemistry ,chemistry.chemical_compound ,chemistry ,Thermal insulation ,Blowing agent ,Ultimate tensile strength ,Materials Chemistry ,Organoclay ,Composite material ,business ,Dispersion (chemistry) ,Cyclopentane ,Polyurethane - Abstract
A process designed to synthesize rigid polyurethane foam (PUF) with insulative properties via the modulation of PUF cell size via the addition of clay and the application of ultrasound was assessed. The blowing agents utilized in this study include water, cyclopentane, and HFC-365mfc, all of which are known to be environmentallyfriendly blowing agents. The rigid PUFs were prepared from polymeric 4,4’-diphenylmethane diisocyanate (PMDI) and polyether polyol with a density of 50 kg/m3. In addition, rigid PUFs/clay nanocomposites were synthesized with clay modified by PMDI with and without the application of ultrasound. The PUF generated using water as a blowing agent evidenced the highest tensile strength. The tensile strength of the PUF/nanocomposites was higher than that of the neat PUF and the strength was even higher with the application of ultrasound. The cell size of the PUF/clay nanocomposites was less than that of the neat PUF, regardless of the type of blowing agent utilized. It appears that the higher tensile strength and lower cell size of the PUF/clay nanocomposites may be attributable to the uniform dispersion of the clay via ultrasonic agitation. The thermal conductivity of the PUF/clay nanocomposites generated with HCFC-141b evidenced the lowest value when PUF/clay nanocomposites were compared with other blowing agents, including HFC-365mfc, cyclopentane, and water. Ultrasound has also proven effective with regard to the reduction of the thermal conductivity of the PUF/clay nanocomposites with any of the blowing agents employed in this study. It has also been suggested that the uniformly dispersed clay particles in the PUF matrix function as diffusion barriers, which prevent the amelioration of the thermal insulation property.
- Published
- 2007
33. Study on the way of Institutionalized Budget for Information Security
- Author
-
So Jeong Kim, Cheol Won Lee, and Seok Jin Choi
- Subjects
Finance ,Certified Information Security Manager ,business.industry ,Computer science ,Standard of Good Practice ,NIST Special Publication 800-53 ,ComputingMilieux_LEGALASPECTSOFCOMPUTING ,Information security ,Computer security ,computer.software_genre ,Security information and event management ,Information security management ,Information security standards ,business ,Personally identifiable information ,computer - Abstract
US is strengthening the information security by managing federal agency`s information and information system systematically. For this purpose. US government put the Federal Information Security Management Act into the E Government Act of 2002. According to the FISMA, it is required to have information securitv management plan for all federal agencies. In addition that, OMB Circular A II requires all federal agencies to identity the ratio of information security investment. That is the basis of strengthening the information security of federal agency, This paper will compare the budget status and information security mechanism of Korea and US.
- Published
- 2007
34. Changes in lung function according to disease extent before and after pulmonary tuberculosis
- Author
-
Yang-Haeng Lee, Hyun Kyung Lee, Hong Gy, Shim Ej, Mee-Young Kim, Ho Young Lee, Youngmin Lee, Song Jw, Seok Jin Choi, and Yousang Ko
- Subjects
Pulmonary and Respiratory Medicine ,Male ,Vital capacity ,medicine.medical_specialty ,Tuberculosis ,Time Factors ,Vital Capacity ,Risk Assessment ,Severity of Illness Index ,Cohort Studies ,FEV1/FVC ratio ,Predictive Value of Tests ,Reference Values ,Internal medicine ,Forced Expiratory Volume ,Severity of illness ,Republic of Korea ,medicine ,Odds Ratio ,Humans ,Tuberculosis, Pulmonary ,Aged ,Retrospective Studies ,integumentary system ,business.industry ,Retrospective cohort study ,Odds ratio ,Middle Aged ,medicine.disease ,Respiratory Function Tests ,Infectious Diseases ,Logistic Models ,Predictive value of tests ,Multivariate Analysis ,Disease Progression ,Female ,business ,Tomography, X-Ray Computed ,Cohort study ,Follow-Up Studies - Abstract
Objective To evaluate changes in lung function in individuals before and after treatment for pulmonary tuberculosis (PTB) in relation to extent of disease. Design Using a retrospective cohort design, changes in and predictors of lung function were evaluated. Results A total of 41 patients were included in the final analysis. The median decline in annualised forced expiratory volume in 1 sec (FEV1) was 180.0 ml/year (95%CI 118.9-356.1) in advanced PTB and 94.7 ml/year (95%CI 33.4-147.3) in localised PTB (ΔFEV1% predicted/year 9.4%, 95%CI 4.4-14.0 vs. 3.8%, 95%CI 1.8-6.2). The median decline in annualised forced vital capacity (FVC) was 309.6 ml/year (95%CI 137.0-359.0) in advanced PTB and 101.1 ml/year (95%CI 30.3-219.6) in localised PTB (ΔFVC % predicted/year 7.3%, 95%CI 5.3-12.3 vs. 2.9%, 95%CI 0.9-6.5). Conclusions As the sample size of our study was small, the conclusions could be biased. Nevertheless, our findings show that PTB causes a significant decline in lung function even in localised PTB, whereas advanced PTB was associated with excessive or even higher decline. This study suggests that early diagnosis and treatment of PTB is needed to preserve lung function.
- Published
- 2015
35. Payment PKI based on EMV and Efficient IC Card Authentication Mechanism
- Author
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Seok Jin Choi, Jea Cheol Ryou, and Sang Heon Song
- Subjects
Authentication ,Computer science ,business.industry ,media_common.quotation_subject ,Public key infrastructure ,Computer security ,computer.software_genre ,Payment ,Chip Authentication Program ,Smart card ,business ,computer ,Mechanism (sociology) ,media_common - Published
- 2004
36. Symptoms of Bacillus Calmette-Guerin Cystitis in Bladder Cancer Patients according to Tuberculosis Sequelae by Chest Radiography
- Author
-
Won Ik Seo, Jang Ho Yoon, Pil Moon Kang, Seok Jin Choi, and Wansuk Kim
- Subjects
Bacillus (shape) ,medicine.medical_specialty ,Tuberculosis ,Bladder cancer ,biology ,business.industry ,Radiography ,medicine.disease ,biology.organism_classification ,Gastroenterology ,Surgery ,Internal medicine ,medicine ,business ,BCG vaccine - Published
- 2017
37. Retroperitoneal fibromatosis presenting as a presacral mass
- Author
-
Seok Jin Choi, Kie Seok Choo, Yong-Woo Kim, and Ung Bae Jeon
- Subjects
medicine.medical_specialty ,magnetic resonance imaging (MRI) ,medicine.diagnostic_test ,business.industry ,Fibromatosis ,presacral mass ,Computed tomography ,Magnetic resonance imaging ,Retroperitoneal fibromatosis ,Case Report ,General Medicine ,retroperitoneum ,medicine.disease ,Surgery ,Familial adenomatous polyposis ,body regions ,Aggressive fibromatosis ,Medicine ,Presacral mass ,business ,Abdominal surgery - Abstract
Aggressive fibromatosis arising from the retroperitoneum is extremely rare. It may occur in association with previous trauma, abdominal surgery, drugs, Gardner’s syndrome, or familial adenomatous polyposis. We report a case of retroperitoneal fibromatosis presenting as a presacral mass with an infiltrating nature, relatively intense enhancement on enhanced computed tomography scanning, and low-signal intensity on T2-weighted magnetic resonance imaging in a patient with no significant medical or surgical history.
- Published
- 2014
38. A Case of Solitary Brain Metastasis from Uterine Mullerian Adenosarcoma with Sarcomatous Overgrowth
- Author
-
Joohan Lim, Suk Bo Hong, Min Jung Kim, Seok Jin Choi, Ji Yeon Kwon, and Eun Young Kim
- Subjects
0301 basic medicine ,Oncology ,medicine.medical_specialty ,Pathology ,Case Report ,Adenosarcoma of the uterus ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Carcinoma ,Mullerian Adenosarcoma ,General Environmental Science ,business.industry ,Brain ,medicine.disease ,030104 developmental biology ,Lymphatic system ,030220 oncology & carcinogenesis ,Variant form ,General Earth and Planetary Sciences ,Primary treatment ,Neurosurgery ,business ,Brain metastasis - Abstract
Uterine adenosarcoma (AS) are rare tumors and have more favorable outcomes than the aggressive uterine carcinosarcomas. Uterine adenosarcoma with sarcomatous overgrowth (ASSO) is a variant form of AS and exhibits aggressive growth of tumor and the prognosis is relatively poor compared with typical AS. Usually patterns of metastasis have been known to behave like endometrial carcinoma and spread through the lymphatics. Brain metastasis from uterine AS is extremely rare. Herein, we report a case of successfully surgically removed solitary brain metastasis without any extracranial recurrence from uterine ASSO after 4 years of primary treatment.
- Published
- 2016
39. Transvenous embolization of cavernous sinus dural arteriovenous fistula using the direct superior ophthalmic vein approach: a case report
- Author
-
Seok Jin Choi, Hyun Sin In, Jong Geun Ha, and Hae Woong Jeong
- Subjects
medicine.medical_specialty ,Fistula ,Facial vein ,medicine.medical_treatment ,Arteriovenous fistula ,Case Report ,lcsh:RC321-571 ,Veins ,Endovascular techniques ,otorhinolaryngologic diseases ,Medicine ,Embolization ,Cavernous sinus ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,lcsh:R5-920 ,business.industry ,Carotid-Cavernous Sinus Fistula ,Inferior petrosal sinus ,Carotid-Cavernous sinus fistula ,medicine.disease ,Surgery ,Radiology ,business ,lcsh:Medicine (General) ,Superior ophthalmic vein - Abstract
Transvenous coil embolization has been successfully applied for the treatment of cavernous sinus dural arteriovenous fistula (CSDAVF). Unfortunately, the technique cannot be applied in cases of poor or absent inferior petrosal sinus or facial venous access route to the fistula. Recently, we experienced a successful embolization using direct superior ophthalmic vein approach in cases of CSDAVF which were no opacification of inferior petrosal sinus or facial vein.
- Published
- 2011
40. Parkinsonism in early Creutzfeldt–Jacob disease: Possible pre- and post-synaptic mechanism
- Author
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Young Eun Kim, Jong Min Kim, Ho Young Lee, Seok Jin Choi, Sang Eun Kim, and Han Yeong Jeong
- Subjects
Neurology ,Creutzfeldt Jacob Disease ,medicine.diagnostic_test ,Mechanism (biology) ,business.industry ,Parkinsonism ,medicine ,Neurology (clinical) ,Electroencephalography ,medicine.disease ,business ,Neuroscience ,Pre and post - Published
- 2014
41. Multiple Symmetric Lipomatosis Presenting with Bilateral Brachial Plexopathy
- Author
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Seok Jin Choi, Kwang Woo Lee, Yoon-Ho Hong, Kee Hong Park, and Jung-Joon Sung
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Lipomatosis ,Interossei ,Anatomy ,Lipoma ,medicine.disease ,Surgery ,body regions ,medicine.anatomical_structure ,Neurology ,Familial Multiple Lipomatosis ,Forearm ,medicine ,Nerve conduction study ,Brachial Plexopathy ,Neurology (clinical) ,business ,Letter to the Editor ,Brachial plexus - Abstract
Dear Editor, Multiple symmetric lipomatosis (MSL), also called Madelung's disease, is a rare disease characterized by the growth of nonencapsulated masses of adipose tissue.1 The disease causes not only cosmetic issues but also various clinical problems depending on the location and extent of the lesion,2 with neuromuscular manifestations such as polyneuropathy, myopathy, and ataxia having been reported.3 Herein we report on a case of bilateral brachial plexopathy caused by extensive lipoma associated with MSL. A 55-year-old man presented with progressive bilateral hand weakness. He first noticed a weak grip with his right hand 2 years before the presentation. The symptom progressed slowly, and his left hand also became weak a few months later. The patient often experienced paresthesia in both arms, but did not complain of proximal arm or leg weakness. He had been drinking about 200 mL of alcohol every day for 30 years. A physical examination revealed excessive soft tissues around his neck, shoulder, and forearm (Fig. 1A). His hand grip, finger abduction, wrist flexion/extension, and elbow extension were extremely weak (Medical Research Council scale grades from 1 to 3) on both sides with muscle atrophy in the first dorsal interossei, hypothenar, and pectoralis major muscles. Deep tendon reflexes were absent in both arms. A nerve conduction study revealed no potentials in the ulnar and radial motor nerves or the medial and lateral antebrachial cutaneous nerves of the left arm. Electromyography revealed positive sharp waves and fibrillation potentials in the first dorsal interosseous, abductor pollicis longus, and extensor carpi radialis of the left arm. Long-duration, high-amplitude motor unit action potentials (MUPs) were present in all muscles of the left arm with reduced recruitment of MUPs. Magnetic resonance images showed extensive fat proliferation and infiltration at the face, neck, shoulder, and axilla that resulted in compression of the brachial plexus (Fig. 1B). He was diagnosed with bilateral brachial plexopathy secondary to MSL, and was operated on to relieve the compression of the brachial plexus. After the surgery, the weaknesses in his hands were slightly improved. Fig. 1 A: Excessive fatty tissues around the neck and shoulder. B: Coronal fat-suppressed T2-weighted MRI reveals the brachial plexus (thick arrow) compressed by lipoma (thin arrow). The incidence of MSL is highest in Mediterranean countries, and it is uncommon in Asia (including Korea). A case-series study of Korean MSL patients found that most patients visited hospital because of a mass lesion and some of them were complicated with peripheral neuropathy.4 The etiology of the disease is not fully understood, but most patients included in previous studies have had a history of chronic excessive alcohol consumption.5 While the exact role of alcohol in the pathophysiology remains elusive, defects in adrenergic stimulated lipolysis or hypertrophy of the brown fat cells have been proposed as an alternative explanation for the pathomechanism.6 The differential diagnosis should include other forms of generalized lipomatosis such as Bannayan-Zonana syndrome, Cowden syndrome, Proteus syndrome, and Dercum disease.7 Familial multiple lipomatosis manifests as multiple encapsulated lipomas with autosomal dominant inheritance, but with relative sparing of the head and shoulders.8 Surgical excision is the treatment of choice. Liposuction can be applied alone9 or in combination with lipectomy.10
- Published
- 2015
42. Cavernous haemangioma of the spermatic cord in a child
- Author
-
Soon Gu Cho, Yong Sun Jeon, Seok Jin Choi, and Won Hong Kim
- Subjects
Male ,Radiography ,Spermatic cord ,Hemangioma ,Diagnosis, Differential ,Scrotum ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Orchiectomy ,Child ,Neuroradiology ,Ultrasonography ,Spermatic Cord ,business.industry ,Anatomy ,medicine.disease ,medicine.anatomical_structure ,Hemangioma, Cavernous ,Pediatrics, Perinatology and Child Health ,Genital neoplasm ,Genital Neoplasms, Male ,Differential diagnosis ,business - Abstract
We present a unique case of an 11-year-old boy with a cavernous haemangioma of the spermatic cord. Sonography showed a well-defined, heterogeneous echoic mass with internal calcifications in the paratesticular region while radiography showed several phleboliths in the scrotum. Both were helpful in differentiating this paratesticular tumour.
- Published
- 2006
43. Optimization of n-junction through ion beam shadowing and buffering effect by tilt implantation with rotation for improving the retention time
- Author
-
Dae-Young Park, Ho-Yup Kwen, Seok-Jin Choi, Jun-Ho Choi, Seung-Han Ok, Deng-Chan Kim, Ji-Bum Kim, Nam-Sung Kim, and Ilgweon Kim
- Subjects
Materials science ,Ion implantation ,Ion beam ,business.industry ,Electric field ,Shallow trench isolation ,Doping ,Electronic engineering ,Optoelectronics ,business ,Dram ,Standard deviation ,Rotation number - Abstract
The novel junction process scheme in submicron DRAM cell with STI (Shallow Trench Isolation) has been investigated to improve the tail component in the retention time distribution which is of great importance in DRAM characteristics. In this paper, we propose the new implantation scheme by gate-related ion beam shadowing effect and buffer-enhanced /spl Delta/RP (projected standard deviation) increase using buffered N-implantation with tilt and 4/spl times/(4 times)-rotation that is designed on the basis of the local-field-enhancement model of the tail component[1]. We report an excellent tail improvement of the retention time distribution attributed to the reduction of electric field across the cell junction due to the redistribution of N-concentration which is intentionally caused by Ion Beam Shadowing and Buffering Effect using tilt implantation with 4/spl times/-rotation. And also, we suggest the least requirements for adoption of this new implantation scheme and the method to optimize the key parameters such as tilt angle, rotation number, Rp compensation and N/sub d//N/sub a/ ratio.
- Published
- 2003
44. Cystic lung disease: a comparison of cystic size, as seen on expiratory and inspiratory HRCT scans
- Author
-
Kyung Jin Nam, Seok Jin Choi, Ki Nam Lee, Jin Mo Goo, and Seong Kuk Yoon
- Subjects
Lung Diseases ,Male ,medicine.medical_specialty ,Pulmonary function testing ,Langerhans cell histiocytosis ,Lung, function ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Cyst ,Expiration ,Honeycombing ,Bronchiectasis ,Lung ,business.industry ,Cysts ,Respiration ,Lung, CT ,respiratory system ,Middle Aged ,Lung, interstitial diseases ,medicine.disease ,Pulmonary lymphangiomyomatosis ,respiratory tract diseases ,medicine.anatomical_structure ,Pulmonary Emphysema ,Lung, cysts ,Female ,Original Article ,Radiology ,business ,Lung Diseases, Interstitial ,Tomography, X-Ray Computed - Abstract
OBJECTIVE To determine the effects of respiration on the size of lung cysts by comparing inspiratory and expiratory high-resolution CT (HRCT) scans. MATERIALS AND METHODS The authors evaluated the size of cystic lesions, as seen on paired inspiratory and expiratory HRCT scans, in 54 patients with Langerhans cell histiocytosis (n = 3), pulmonary lymphangiomyomatosis (n = 4), confluent centrilobular emphysema (n = 9), paraseptal emphysema and bullae (n = 16), cystic bronchiectasis (n = 13), and honeycombing (n = 9). Using paired inspiratory and expiratory HRCT scans obtained at the corresponding anatomic level, a total of 270 cystic lesions were selected simultaneously on the basis of five lesions per lung disease. Changes in lung cyst size observed during respiration were assessed by two radiologists. In a limited number of cases (n = 11), pathologic specimens were obtained by open lung biopsy or lobectomy. RESULTS All cystic lesions in patients with Langerhans cell histiocytosis, lymphangiomyomatosis, cystic bronchiectasis, honeycombing, and confluent centrilobular emphysema became smaller on expiration, but in two cases of paraseptal emphysema and bullae there was no change. CONCLUSION In cases in which expiratory CT scans indicate that cysts have become smaller, cystic lesions may communicate with the airways. To determine whether, for cysts and cystic lesions, this connection does in fact exist, paired inspiratory and expiratory HRCT scans are necessary.
- Published
- 2001
45. Imaging of occupational lung disease
- Author
-
Choong-Ki Park, Jong Gi Kim, Kun-Il Kim, Kyung Soo Lee, Min Ki Lee, Seok Jin Choi, and Changwon Kim
- Subjects
Lung Diseases ,medicine.medical_specialty ,Lung ,business.industry ,Pneumoconiosis ,Asbestosis ,Disease ,Pneumonia ,medicine.disease ,respiratory tract diseases ,Occupational Diseases ,Chemical pneumonitis ,medicine.anatomical_structure ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radiology ,Occupational lung disease ,business ,Tomography, X-Ray Computed ,Hypersensitivity pneumonitis - Abstract
Occupational lung disease comprises a wide variety of disorders caused by the inhalation or ingestion of dust particles or noxious chemicals. These disorders include pneumoconiosis, asbestos-related pleural and parenchymal disease, chemical pneumonitis, occupational infection, hypersensitivity pneumonitis, and organic dust toxic syndrome. Most of these disorders produce diffuse lung disease. Although many of the disorders can be detected at chest radiography, high-resolution computed tomography (CT) has been shown to be superior to chest radiography in depicting parenchymal, airway, and pleural abnormalities. Some occupational lung diseases have characteristic radiologic features suggesting the correct diagnosis, whereas in others, a combination of clinical features, related occupational history, radiologic findings, and literature supporting an association between the exposure and the disease process is required for diagnosis. With advances in chest radiology, including high-resolution CT, radiologists play a key role in the clinical evaluation of occupational lung diseases and should continue their involvement in the diagnosis and treatment of these diseases.
- Published
- 2001
46. Evaluation of Cardiovascular Anomalies in Patients with Asymptomatic Turner Syndrome Using Multidetector Computed Tomography
- Author
-
Seok Jin Choi, Ji Mi Jung, Min Seob Song, Woo Yeong Chung, and Sun Hee Lee
- Subjects
medicine.medical_specialty ,Adolescent ,Vascular Malformations ,Cardiovascular Disorders ,Vertebral artery ,Cardiovascular Abnormalities ,Partial anomalous pulmonary venous return ,Turner Syndrome ,Blood Pressure ,Asymptomatic ,Electrocardiography ,Young Adult ,Internal medicine ,medicine.artery ,Multidetector Computed Tomography ,Turner syndrome ,Prevalence ,medicine ,Humans ,cardiovascular diseases ,Persistent left superior vena cava ,Cardiovascular Malformation ,Vertebral Artery ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,General Medicine ,medicine.disease ,Blood pressure ,Karyotyping ,cardiovascular system ,Cardiology ,Original Article ,Radiology ,medicine.symptom ,business - Abstract
Turner syndrome is well known to be associated with significant cardiovascular abnormalities. This paper studied the incidence of cardiovascular abnormalities in asymptomatic adolescent patients with Turner syndrome using multidetector computed tomography (MDCT) instead of echocardiography. Twenty subjects diagnosed with Turner syndrome who had no cardiac symptoms were included. Blood pressure and electrocardiography (ECG) was checked. Cardiovascular abnormalities were checked by MDCT. According to the ECG results, 11 had a prolonged QTc interval, 5 had a posterior fascicular block, 3 had a ventricular conduction disorder. MDCT revealed vascular abnormalities in 13 patients (65%). Three patients had an aberrant right subclavian artery, 2 had dilatation of left subclavian artery, and others had an aortic root dilatation, aortic diverticulum, and abnormal left vertebral artery. As for venous abnormalities, 3 patients had partial anomalous pulmonary venous return and 2 had a persistent left superior vena cava. This study found cardiovascular abnormalities in 65% of asymptomatic Turner syndrome patients using MDCT. Even though, there are no cardiac symptoms in Turner syndrome patients, a complete evaluation of the heart with echocardiography or MDCT at transition period to adults must be performed.
- Published
- 2013
47. Retrospective Analysis of Adverse Reactions to Iodinated Contrast Media in Korean
- Author
-
Seok Jin Choi, Jae-Gook Shin, Jong Ryul Ghim, Min Kyung Oh, Eun Young Kim, Hee Hyun Kim, and Ji yeob Choi
- Subjects
medicine.medical_specialty ,business.industry ,Iopromide ,Cancer ,Retrospective cohort study ,Logistic regression ,medicine.disease ,Iobitridol ,Iodixanol ,chemistry.chemical_compound ,chemistry ,Internal medicine ,Medicine ,Pharmacology (medical) ,Iohexol ,Adverse effect ,business ,medicine.drug - Abstract
Background: This study was performed to evaluate the prevalence and risk factors on the adverse reactions caused by iodinated contrast media (CM) for computed tomography (CT) examination in a university hospital. Methods: Clinical and demographic data among outpatients with CM use were collected at 0000 University Busanpaik Hospital in Busan, Korea between 2008 and 2010. Adverse reaction rate was calculated by the number of adverse reaction among total outpatients with CM use, which was stratified by seasons and sex. The association of risk factors on adverse reaction was investigated using logistic regression model. Results: The total outpatients and events of administered CMs were 27,587 and 48,616, respectively. The administered CMs were iopromide, iohexol, iobitridol, and iodixanol. Adverse reactions occurred in 300 outpatients among the total outpatients (1.1 %). The number of outpatients administered CM more than twice were 8,348. Among them, outpatients who experienced adverse reaction(s) more than once and twice were 124 (1.5 %) and 26 (0.3 %), respectively. Adverse reaction rate was significantly different by sex(p=0.01). The other risk factors were cancer history (OR 2.57, 95 % CI 2.00-3.31) and previous CM administration (OR 1.89, 95 % CI 1.47-2.44). Urticaria was the most frequent symptoms. Conclusion: Total adverse reaction rate was 1.1 % with most common symptom in skin system. Related risk factors were female, cancer history, and previous CM administration. These results were similar to previous studies and will be contribute to clinical practice and future research especially in Koreans.
- Published
- 2012
48. Long-term disease-free survival after surgical resection for multiple bone metastases from rectal cancer
- Author
-
Ja Hong Kuh, Min Ro Lee, Jung Ryul Kim, Jong Hun Kim, Chang Ho Lee, and Seok Jin Choi
- Subjects
Surgical resection ,Disease free survival ,medicine.medical_specialty ,business.industry ,Colorectal cancer ,Treatment options ,Bone metastasis ,Disease ,medicine.disease ,Surgery ,Oncology ,Bone lesion ,Medicine ,Multimodal treatment ,Topic Highlight ,business - Abstract
Bone metastasis of primary colorectal cancer is uncommon. When it occurs, it is usually a late manifestation of disease and is indicative of poor prognosis. We describe a patient with multiple metachronous bone metastases from lower rectal cancer who was successfully treated with multimodal treatment including surgical resections and has shown 32 mo disease-free survival. Surgical resection of metastatic bone lesion(s) from colorectal cancer may be a good treatment option in selected patients.
- Published
- 2011
49. Long-term Follow-up Sonography of Benign Cystic Thyroid Nodules after a Percutaneous Ethanol Injection: The Incidence of Malignancy-mimicking Nodules
- Author
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Ji Sung Park, Choong Ki Eun, Myung Ho Rho, Dong Wook Kim, and Seok Jin Choi
- Subjects
Thyroid nodules ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,medicine.medical_treatment ,Malignancy ,medicine.disease ,Group A ,Group B ,Sclerotherapy ,Medicine ,Radiology ,Ultrasonography ,Percutaneous ethanol injection ,business - Abstract
Purpose: To evaluate the incidence of malignancy-mimicking sclerosed thyroid nodules, from long-term follow-up ultrasonography (US) after an US-guided percutaneous ethanol injection (PEI). Materials and Methods: We examined 86 benign cystic thyroid nodules from 80 patients. The nodules were classified into two groups based on whether an aspiration (Group A, n=26) or non-aspiration (Group B, n=60) of infused ethanol was performed. The final follow-up US over 12 months was performed in all patients. Results: Of the 86 nodules, the cystic portion of 82 (95.3%) cases, from 76 patients, completely disappeared subsequent to the first follow-up US (Group A, n=24, Group B, n=58) (Chi-square test, p>0.05). Moreover, 46 sclerosed thyroid nodules showed two or more of the 'five sonographic criteria' upon a follow-up US (Group A, n=13, 50.0%, Group B, n=32, 53.3%). A higher ratio of the cystic portion of the nodules was associated with a higher incidence of the 'five sonographic criteria' for malignancies detected via a follow-up US (p
- Published
- 2008
50. Transverse Testicular Ectopia Diagnosed by US and MR Imaging: A Case Report
- Author
-
Hye-Sun Cho, Seok Jin Choi, Seong Sook Cha, and Yong-Woo Kim
- Subjects
Inguinal hernia ,medicine.medical_specialty ,Ectopic testis ,Both testes ,business.industry ,medicine ,Testicular ectopia ,Radiology ,Inguinal herniotomy ,medicine.disease ,business ,Mr imaging ,Surgery - Abstract
Transverse testicular ectopia (TTE) is a rare congenital anomaly in which both testes migrate toward the same hemiscrotum. In most cases, the correct diagnosis is not made preoperatively, but it's made during an inguinal herniotomy or during surgical exploration for an undescended testis because TTE is clinically misdiagnosed as an symptomatic inguinal hernia or as a tumor of the testis on the side to which the ectopic testis has migrated or as an undescended testis on the contralateral side. US and MR imaging can detect the transverse testicular ectopia by its characteristic appearance and so provide useful information about any associated anomalies. We report here on a case of transverse testicular ectopia that was diagnosed by US and MR imaging in a 10-month-old boy, and we review the relevant literature.
- Published
- 2007
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