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Background: Adolescent obesity is one of the most serious public health challenges of the 21st century having high prevalence rate in low- and middle-income countries, including in Asia. The relationship between BMI and body fat percentage (BF %) has been studied in various ethnic groups to estimate the ability of BMI to predict adiposity. Accuracy of obesity screening by commonly used BMI criteria is unclear in young south Indian population.Materials and method: A total of 2212 participant (1320 males and 892 females) mean age was 11.5±1.6 years. BMI and BF% were recorded, the latter was determined by bioelectrical impedance analysis (BIA). Height and weight were measured and BMI was calculated (kg/m2)). A comparison between study population and previously available nationally representative (1989) data was performed for each age-sex group. WHO cut-off values were used and their respective status was assigned. The prevalence of overweight and obesity was expressed in percentagesResults: The prevalence of overweight and obesity was found to be 21.6% and 10.4%, respectively as per BMI category, while according to BF%, it was 17.0% and 10.9% respectively and the mean differences were found to be statistically significant (P=0.001. The fat percentages in girls were higher than in boys. BMI noted to increase with age in young in both boys and girls. This curvilinear effect was more significant in females (R2 = 0.27, R2 change = 0.058, SEE 11.5%) (p =

Introduction: Noninvasive prenatal testing (NIPT) is a reliable screening method for fetal aneuploidy detection of trisomy 18, 13, 21 along with few sex chromosome abnormalities monosomy X, XXX, XXY (Klinefelter), XYY (Jacob) syndromes and certain microdeletions which include cri-du-chat, DiGeorge, 1p36, Angelman, and Prader-Willi syndromes in comparison to the available screening methods. Prenatal screening of Turners syndrome is possible by ultrasound in certain conditions only. Recently benefits of early detection and treatment of Turners syndrome has been emphasized, enforcing on accurate and early screening prenatally.Case details: The current case emphasizes on the reliability of NIPT testing which comes with an advantage of early screening. A 24-year-old primi gravida was referred for NIPT as she tested for high risk on biochemical screening. The Panorama™ NIPT results showed low risk for trisomies, 21, 18, and 13 but high risk of monosomy X and was advised confirmatory amniocentesis. The fluorescence in situ hybridization (FISH) report revealed no numerical abnormality detected for any of the five chromosomes tested. On receiving this discordant report, the sample was rerun for NIPT, to rule out any laboratory-related issues. The result obtained on a rerun was consistent with the first report and showed monosomy X again. The karyotype report was available three weeks later and a rare variant of Turners syndrome was identified.Discussion: Panorama™ NIPT considers single nucleotide polymorphisms spread across the chromosomes for analysis, different variants of aneuploidy can be picked up in comparison to FISH, similar to the current case wherein it could not as it was a centromeric probe. Reported first case of X chromosome variant detected by NIPT confirmed by karyotyping, missed by FISH.

Introduction: carcinomas in the lung, breast, and lymphomas are known to metastasize to the adrenal gland. However, these metastases initially do not present with signs and symptoms of adrenal insufficiency leading to a decreased chance of adrenal insufficiency being diagnosed. We report a case of adrenal insufficiency due to bilateral adrenal metastases as the presenting manifestation of gastric carcinoma. case report: A 72-year-old male was admitted to our hospital due to altered mental status, weakness, anorexia, hematemesis and urinary incontinence for three days. Hyponatremia, hyperkalemia, anemia, and mild metabolic acidosis were detected. A diagnosis of gastric carcinoma along with bilateral metastases of the adrenal glands was made after biopsy computed tomography and positron emission tomography scans. Initiation of mineralocorticoid replacement therapy, improved the condition of patient. conclusion: there are only a few reports of adrenal insufficiency or true Addisonian crisis being the