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Purpose: to set out morphofunctional differences in the ophthalmic status between suspected glaucoma (SG) and the initial stage of primary open angle glaucoma (POAG), determine the values of interocular asymmetry of the analyzed parameters of fellow eyes and create a model able to distinguish, with high accuracy, between healthy subjects, SG patients and POAG patients relying on a few independent parameters. Material and methods. A multicenter study performed between July and November, 2016, by 34 research and clinical facilities of four countries (Russia, Belarus, Uzbekistan, and Moldova) involved 501 patients (824 eyes), of which 362 (72 %) were female and 139 (28 %) male. The main analyzed group consisted of 128 eyes with SG, 228 eyes with early stage POAG and 145 eyes of healthy subjects (the control group with comparable sex and age distribution and no history of glaucoma). The fellow-eye symmetry analysis group involved 190 eyes with SG, 336 eyes with early stage POAG and 220 eyes of 110 subjects with no glaucoma. Results. Differences were found in the structural and functional ophthalmologic parameters in early-stage POAG, SG, and the absence of glaucoma. The precision of SG and early POAG may be increased by cumulative consideration of several clinical parameters. Conclusions. The sensitivity and specificity of the integral index of condition prognostication increases when several parameters are analyzed simultaneously, as compared to the separate analysis of constituents. For citations: Avdeev R.V., Alexandrov A.S., Arapiev M.U., et al. Suspected glaucoma and early stage glaucoma: differential diagnostic criteria. Russian ophthalmological journal. 2017; 10 (4): 5-15. doi: 10.21516/2072-0076-2017-10-4-5-15 (In Russian).

Introduction. For the past several decades, there has been a discussion as to whether elevated intraocular pressure is just ocular hypertension in a healthy eye, or a sign of glaucoma. Objective. To study the IOP values in patients with primary open-angle glaucoma at the beginning of the study and to correlated them with the disease progression and to determine optimal IOP levels. Material and methods. The final protocol included data from 812 right eyes of 637 glaucoma patients and 175 healthy subjects; the latter formed the control group. The mean age of examined patients was 71.8 ± 0.28 years; 72.00 (66.00; 77.00). Mean disease duration in glaucoma patients was 5.41 ± 0.17 years. The following parameters were assessed: visual acuity, clinical refraction, IOP level by Maklakov tonometry, central corneal thickness and IOP-lowering medication use. Results. In the age group - between 60 and 69 y.o., the IOP level in patients with advanced glaucoma was significantly higher than in patients with moderate glaucoma and healthy subjects. There was no significant difference in central corneal thickness either between glaucoma patients and healthy subjects (both male and female) or between glaucoma patients with different glaucoma changes. The IOP level was higher in patients treated with non-fixed combination of beta-blockers (BB) and prostaglandins (PG) regardless of the disease stage. According to the common standards the IOP level was found to be controlled in 69.93 % of patients with moderate glaucoma and 14.42 % of patients with advanced glaucoma. Conclusion. The results of the study could be used as clinical guidelines for determination of the optimal IOP range, choosing the optimal IOP-lowering medication(s) for starting therapy and during the follow-up in patients with moderate and advanced glaucoma stages.