1. Influence of moxibustion on NR2B and PKMζ after neural stem cell transplantation in the rats with vascular dementia
- Author
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Rong Ji (季荣), Wan-lin Zhang (张万林), Jing-cheng Cui (崔竞成), Pin Wang (王频), Yin-qiu Fan (樊吟秋), Rui Sun (孙睿), Shan Wang (王珊), and Jun Yang
- Subjects
business.industry ,medicine.medical_treatment ,Therapeutic effect ,Neurogenesis ,0211 other engineering and technologies ,Morris water navigation task ,Hippocampus ,02 engineering and technology ,Moxibustion ,Pharmacology ,medicine.disease ,030226 pharmacology & pharmacy ,Neural stem cell ,03 medical and health sciences ,0302 clinical medicine ,nervous system ,Complementary and alternative medicine ,021105 building & construction ,medicine ,Spatial learning ,business ,Vascular dementia - Abstract
Objective To observe the influence of moxibustion on learning and memory ability in the rats with vascular dementia (VD) and explore the potential effect mechanism. Methods A total of 80 rats, screened by Morris water maze, were randomly divided into a sham-operation group, a model group, a neural stem cells (NSCs) group, a NSCs + piracetam group and a NSCs + moxibustion group, 16 rats in each group. After corresponding treatments, Morris water maze and immunofluorescence technique were adopted to evaluate the therapeutic effect respectively. Results Comparison among groups after modeling: compared with the sham-operation group, the escape latency was longer (P Conclusion Moxibustion improves the spatial learning and memory ability of the VD rats and promotes the reconstruction of neurogenesis and synaptic function, which may be related to the up-regulation of the expressions of hippocampus NR2B and PKMζ expressions.
- Published
- 2021