Author: "Qi Bao" / Topic: business.industry - Searchworks@Jio Institute Digital Library Search Results

84 results on '"Qi Bao"'

1. Prediction on freight function structure of China’s coastal ports under the Polar Silk Road: a cargo attraction potential perspective

Author: Xinfang Zhang, Zhenfu Li, Xiangdong Li, Qi Bao, and Yan Peng
Subjects: Economics and Econometrics, business.industry, media_common.quotation_subject, 05 social sciences, Geography, Planning and Development, Environmental resource management, 0507 social and economic geography, Attraction, 0506 political science, The arctic, Geography, Trade route, 050602 political science & public administration, business, Function (engineering), China, 050703 geography, Northwest europe, media_common
Abstract: The Polar Silk Road (PSR) will open up China’s maritime trade route through the Arctic to Northwest Europe and affect the freight function structure of China’s coastal ports. This study evaluates p...
Published: 2020

2. Highly Efficient Orange Emissive Graphene Quantum Dots Prepared by Acid-Free Method for White LEDs

Author: Da-Ming Ye, Gui-Gen Wang, Long-Fei Liu, Qi-Bao Wu, You-Xiao Chen, Jia-Shun Huang-Fu, Bo Yan, Xiao-Fei Wang, Jiecai Han, and Dong Lu
Subjects: Materials science, Condensed Matter::Other, Renewable Energy, Sustainability and the Environment, Graphene, business.industry, General Chemical Engineering, Physics::Optics, Quantum yield, 02 engineering and technology, General Chemistry, Orange (colour), 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Optical stability, 0104 chemical sciences, law.invention, Condensed Matter::Materials Science, law, Quantum dot, Environmental Chemistry, Optoelectronics, 0210 nano-technology, business, Light-emitting diode
Abstract: Graphene quantum dots (GQDs) have wide prospective applications for optoelectronic fields owing to their unique characteristics, such as tunable bandgaps, high chemical and optical stability, as we...
Published: 2020

3. Antidiabetic Effects and Mechanisms of Rosemary (Rosmarinus officinalisL.) and its Phenolic Components

Author: Tian-Qi Bao, Zu-Guo Zheng, Hua Yang, Ping Li, Yi Li, and Cheng Qu
Subjects: 0301 basic medicine, biology, Traditional medicine, business.industry, Carnosic acid, Lipid metabolism, General Medicine, Hypoglycemia, biology.organism_classification, medicine.disease, Carnosol, Rosmarinus, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Insulin resistance, Complementary and alternative medicine, chemistry, 030220 oncology & carcinogenesis, Diabetes mellitus, Officinalis, Medicine, business
Abstract: Diabetes mellitus is a chronic endocrine disease result from absolute or relative insulin secretion deficiency, insulin resistance, or both, and has become a major and growing public healthy menace worldwide. Currently, clinical antidiabetic drugs still have some limitations in efficacy and safety such as gastrointestinal side effects, hypoglycemia, or weight gain. Rosmarinus officinalis is an aromatic evergreen shrub used as a food additive and medicine, which has been extensively used to treat hyperglycemia, atherosclerosis, hypertension, and diabetic wounds. A great deal of pharmacological research showed that rosemary extract and its phenolic constituents, especially carnosic acid, rosmarinic acid, and carnosol, could significantly improve diabetes mellitus by regulating glucose metabolism, lipid metabolism, anti-inflammation, and anti-oxidation, exhibiting extremely high research value. Therefore, this review summarizes the pharmacological effects and underlying mechanisms of rosemary extract and its primary phenolic constituents on diabetes and relative complications both in vitro and in vivo studies from 2000 to 2020, to provide some scientific evidence and research ideas for its clinical application.
Published: 2020

4. High Illumination Uniformity Inverted Plant Light Source Design with Bulge Structure

Author: 马丙戌 Ma Bing-xu, 陈妍如 Chen Yan-ru, 张博 Zhang Bo, 焦飞宇 Jiao Feiyu, 靳肖林 Jin Xiao-lin, 蔡明兴 Cai Ming-xing, 姜昕宇 Jiang Xin-yu, 左欣 Zuo Xin, 吴启保 Wu Qi-bao, and 文尚胜 Wen Shang-sheng
Subjects: Radiation, Optics, Materials science, Light source, business.industry, Bulge, Condensed Matter Physics, business, Electronic, Optical and Magnetic Materials
Published: 2020

5. Highly Uniform LED Plant Light Source with Curved Reflective Surface

Author: 姜昕宇 Jiang Xin-yu, 吴启保 Wu Qi-bao, 文尚胜 Wen Shang-sheng, 马丙戌 Ma Bing-xu, and 卢允乐 Lu Yun-le
Subjects: Surface (mathematics), Radiation, Light source, Materials science, Optics, business.industry, Condensed Matter Physics, business, Electronic, Optical and Magnetic Materials
Published: 2020

6. Effect of Intraoperative Ventilation Strategies on Postoperative Pulmonary Complications: A Meta-Analysis

Author: Pengfei Huang, Huanyu Luo, Junran Xie, Min Lei, and Qi Bao
Subjects: Mechanical ventilation, RD1-811, business.industry, Pleural effusion, medicine.medical_treatment, Atelectasis, medicine.disease, Pulmonary edema, Confidence interval, Pulmonary embolism, Pneumothorax, conventional mechanical ventilation, Anesthesia, atelectasis, medicine, Breathing, low tidal volume ventilation, postoperative pulmonary complications, Surgery, Systematic Review, length of hospital stay, business
Abstract: Introduction: The role of intraoperative ventilation strategies in subjects undergoing surgery is still contested. This meta-analysis study was performed to assess the relationship between the low tidal volumes strategy and conventional mechanical ventilation in subjects undergoing surgery.Methods: A systematic literature search up to December 2020 was performed in OVID, Embase, Cochrane Library, PubMed, and Google scholar, and 28 studies including 11,846 subjects undergoing surgery at baseline and reporting a total of 2,638 receiving the low tidal volumes strategy and 3,632 receiving conventional mechanical ventilation, were found recording relationships between low tidal volumes strategy and conventional mechanical ventilation in subjects undergoing surgery. Odds ratio (OR) or mean difference (MD) with 95% confidence intervals (CIs) were calculated between the low tidal volumes strategy vs. conventional mechanical ventilation using dichotomous and continuous methods with a random or fixed-effect model.Results: The low tidal volumes strategy during surgery was significantly related to a lower rate of postoperative pulmonary complications (OR, 0.60; 95% CI, 0.44–0.83, p < 0.001), aspiration pneumonitis (OR, 0.63; 95% CI, 0.46–0.86, p < 0.001), and pleural effusion (OR, 0.72; 95% CI, 0.56–0.92, p < 0.001) compared to conventional mechanical ventilation. However, the low tidal volumes strategy during surgery was not significantly correlated with length of hospital stay (MD, −0.48; 95% CI, −0.99–0.02, p = 0.06), short-term mortality (OR, 0.88; 95% CI, 0.70–1.10, p = 0.25), atelectasis (OR, 0.76; 95% CI, 0.57–1.01, p = 0.06), acute respiratory distress (OR, 1.06; 95% CI, 0.67–1.66, p = 0.81), pneumothorax (OR, 1.37; 95% CI, 0.88–2.15, p = 0.17), pulmonary edema (OR, 0.70; 95% CI, 0.38–1.26, p = 0.23), and pulmonary embolism (OR, 0.65; 95% CI, 0.26–1.60, p = 0.35) compared to conventional mechanical ventilation.Conclusions: The low tidal volumes strategy during surgery may have an independent relationship with lower postoperative pulmonary complications, aspiration pneumonitis, and pleural effusion compared to conventional mechanical ventilation. This relationship encouraged us to recommend the low tidal volumes strategy during surgery to avoid any possible complications.
Published: 2021

7. HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson’s disease models

Author: Cheng Ju, Hui Liu, Fangyuan Li, Lu Wang, Xiu-Qi Bao, Junmei Shang, Dan Zhang, Zihong Zhang, Fang-Yu Yuan, Caixia Zang, and Hanyu Yang
Subjects: HECT domain, Male, rac1 GTP-Binding Protein, Parkinson's disease, Ubiquitin-Protein Ligases, Blotting, Western, Fluorescent Antibody Technique, RAC1, medicine.disease_cause, Article, Pathogenesis, Mice, Parkinsonian Disorders, Cell Line, Tumor, medicine, Animals, Humans, Pharmacology (medical), Neuroinflammation, Pharmacology, Gene knockdown, NADPH oxidase, biology, business.industry, Ubiquitination, General Medicine, medicine.disease, Cell biology, Mice, Inbred C57BL, HEK293 Cells, Rotarod Performance Test, Neuroinflammatory Diseases, biology.protein, business, Oxidative stress
Abstract: Neuroinflammation plays an important role in neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease. HACE1 (HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1) is a tumor suppressor. Recent evidence suggests that HACE1 may be involved in oxidative stress responses. Due to the critical role of ROS in neuroinflammation, we speculated that HACE1 might participate in neuroinflammation and related neurodegenerative diseases, such as PD. In this study, we investigated the role of HACE1 in neuroinflammation of PD models. We showed that HACE1 knockdown exacerbated LPS-induced neuroinflammation in BV2 microglial cells in vitro through suppressing ubiquitination and degradation of activated Rac1, an NADPH oxidase subunit. Furthermore, we showed that HACE1 exerted vital neuronal protection through increasing Rac1 activity and stability in LPS-treated SH-SY5Y cells, as HACE1 knockdown leading to lower tolerance to LPS challenge. In MPTP-induced acute PD mouse model, HACE1 knockdown exacerbated motor deficits by activating Rac1. Finally, mutant α-synuclein (A53T)-overexpressing mice, a chronic PD mouse model, exhibited age-dependent reduction of HACE1 levels in the midbrain and striatum, implicating that HACE1 participated in PD pathological progression. This study for the first time demonstrates that HACE1 is a negative regulator of neuroinflammation and involved in the PD pathogenesis by regulating Rac1 activity. The data support HACE1 as a potential target for PD and other neurodegenerative diseases.
Published: 2021

8. Global burden of thyroid cancer and its attributable risk factors in 204 countries and territories from 1990 to 2019

Author: Qian-Qian Yuan, Wen-Qi Bao, Lu-Yao Li, Tong Deng, and Hao Zi
Subjects: Pulmonary and Respiratory Medicine, Burden of disease, Adult, Male, Adolescent, burden of disease, Global Burden of Disease, Young Adult, Risk Factors, medicine, Cancer burden, thyroid cancer, Humans, Thyroid Neoplasms, Risk factor, Child, Thyroid cancer, RC254-282, Aged, Aged, 80 and over, business.industry, Incidence (epidemiology), Mortality rate, Incidence, Infant, Newborn, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Infant, General Medicine, Original Articles, Middle Aged, medicine.disease, disability‐adjusted life‐years, mortality, Oncology, Child, Preschool, Attributable risk, Female, Original Article, Age of onset, business, Demography
Abstract: Background To investigate the burden of thyroid cancer and its attributable risk factors in 204 countries and territories during 30 years. Methods We extracted data from the Global Burden of Disease (GBD) 2019 database, including incidence, mortality, disability‐adjusted life‐years (DALYs), and the attributable risk factors of thyroid cancer from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to assess the changes in age‐standardized incidence rate (ASIR), age‐standardized mortality rate (ASMR), and age‐standardized DALYs rate (ASDR). We also examined the associations between cancer burden and the sociodemographic index (SDI). Results The global new cases, death, and DALYs of thyroid cancer in 2019 were 233 847 (95% UI: 211 637–252 807), 45 576 (95% UI: 41 290‐48 775), and 1 231 841 (95% UI: 1 113 585–1 327 064), respectively. From 1990 to 2019, the ASIR of thyroid cancer showed an upward trend (EAPC = 1.25), but ASMR (EAPC = −0.15) and ASDR (EAPC = −0.14) decreased. The burden of thyroid cancer varied at regional and national levels, but the association between ASIR and SDI was positive. We found that the burden of thyroid cancer was mainly concentrated in females and that the age of onset tended to be younger. The proportion of DALYs from thyroid cancer attributable to high body‐mass index was higher in high SDI regions, especially in males. Conclusions The global incidence of thyroid cancer has continued to increase in the past three decades. The high body‐mass index as an important risk factor for thyroid cancer deserves greater attention, especially in high SDI regions., The burden of thyroid cancer varies in 204 countries and territories from 1990 to 2019. The global incidence of thyroid cancer (a) has increased significantly, while the mortality (b) and DALYs (c) have decreased in the past three decades.
Published: 2021

9. Gardenia jasminoides J.Ellis extract GJ-4 alleviated cognitive deficits of APP/PS1 transgenic mice

Author: Hui Liu, Xiu-Qi Bao, Zihong Zhang, Chanjuan Sheng, Yao Xinsheng, Hanyu Yang, Lu Wang, Caixia Zang, Yang Yu, Dan Zhang, and Junmei Shang
Subjects: Genetically modified mouse, Tau protein, Pharmaceutical Science, Morris water navigation task, Mice, Transgenic, Pharmacology, Neuroprotection, Mice, Phosphatidylinositol 3-Kinases, Cognition, mental disorders, Drug Discovery, medicine, Animals, Cognitive Dysfunction, Donepezil, Neuroinflammation, PI3K/AKT/mTOR pathway, Microglia, biology, business.industry, Gardenia, medicine.anatomical_structure, Complementary and alternative medicine, biology.protein, Molecular Medicine, business, medicine.drug, Drugs, Chinese Herbal
Abstract: Background Accumulating evidence demonstrates that traditional Chinese medicines that act on multiple targets could effectively treat various multi-etiological diseases, including cerebrovascular diseases, Alzheimer's disease (AD), Parkinson's disease (PD) and so on. Previous studies have shown that crocin richments (GJ-4), Gardenia jasminoides J.Ellis extract, provide neuroprotective effects on cognitive impairments in AD mouse models. However, the mechanism how GJ-4 improves cognition remains still unclear. Purpose The aim of this study was to uncover the protective effects and underlying mechanism of GJ-4 on PrP-hAβPPswe/PS1ΔE9 (APP/PS1) transgenic mice. Methods APP/PS1 mice were given GJ-4 (10, 20, and 50 mg/kg), donepezil (5 mg/kg) and memantine (5 mg/kg) orally at eight months of age for 12 consecutive weeks. Morris water maze and novel object recognition were conducted to assess the cognitive ability of mice. The release of inflammatory cytokines was determined by RT-PCR assay, and the pathological features of neurons and microglia were assayed by immunohistochemistry and immunofluorescence assay. The expression of Aβ-related proteins and signaling pathways were determined by Western blot. Results The behavioral results revealed that GJ-4 ameliorated the cognitive deficits of APP/PS1 mice measured by Morris water maze and novel object recognition tests. Mechanism studies indicated that GJ-4 significantly decreased β-amyloid (Aβ) level through reducing Aβ production and promoting Aβ degradation. It has been reported that Aβ plaques trigger the hyper-phosphorylation of tau protein in APP/PS1 mice. Consistent with previous studies, hyper-phosphorylation of tau was also occurred in APP/PS1 mice in the present study, and GJ-4 inhibited Tau phosphorylation at different sites. Overwhelming evidence indicates that neuroinflammation stimulated by Aβ and hyperphosphorylated tau is involved in the pathological progression of AD. We found that GJ-4 suppressed neuroinflammatory responses in the brain through regulating phosphatidylinositide 3-kinase/AKT (PI3K/AKT) signaling pathway activation, and subsequent expression of inflammatory proteins and release of inflammatory cytokines. Conclusion Altogether, GJ-4 ameliorated cognition of APP/PS1 transgenic mice through multiple targets, including Aβ, tau and neuroinflammation. This study provides a solid research basis for further development of GJ-4 as a potential candidate for the treatment of AD.
Published: 2021

10. Different Hepatitis C Virus Infection Statuses Show a Significant Risk of Developing Type 2 Diabetes Mellitus: A Network Meta-Analysis

Author: Yulong Jia, Jianguo Shao, Jianan Zhu, Yi Shen, Hanzhen Ji, Qi Bao, Lei Zhang, and Ying Chen
Subjects: Liver Cirrhosis, medicine.medical_specialty, Cirrhosis, endocrine system diseases, Physiology, Hepatitis C virus, Network Meta-Analysis, Remission, Spontaneous, medicine.disease_cause, Lower risk, Severity of Illness Index, End Stage Liver Disease, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Odds Ratio, medicine, Humans, Significant risk, business.industry, Gastroenterology, Hcv clearance, nutritional and metabolic diseases, virus diseases, Type 2 Diabetes Mellitus, Hepatitis C Antibodies, Hepatitis C, Chronic, Hepatology, medicine.disease, Hepatitis C, digestive system diseases, Diabetes Mellitus, Type 2, Case-Control Studies, 030220 oncology & carcinogenesis, Meta-analysis, Acute Disease, 030211 gastroenterology & hepatology, business
Abstract: The role of hepatitis C virus (HCV) infection statuses in the development of type 2 diabetes mellitus (T2DM) has not been completely understood. To evaluate the prevalence of T2DM in patients with different HCV infection statuses. We conducted a systematic study on T2DM risk in five types of individuals with different HCV infection statuses: non-HCV controls, HCV-cleared patients, chronic HCV patients without cirrhosis, patients with HCV cirrhosis and patients with decompensated HCV cirrhosis. Studies published from 2010 to 2019 were selected. Both pairwise and network meta-analyses were employed to compare the T2DM risk among patients with different HCV infection statuses. The pairwise meta-analysis showed that non-HCV (OR = 0.60, 95% CI [0.47–0.78]) had a lower risk of T2DM compared with CHC, while cirrhosis had a significant higher risk (OR = 1.90, 95% CI [1.60–2.26]). Network meta-analysis further demonstrated patients with HCV infection were at a significantly higher risk of T2DM than those without HCV infection or with HCV clearance, while decompensated cirrhosis had a significant higher T2DM risk than non-HCV (OR = 3.84, 95% CI [2.01–7.34]), patients with HCV clearance (OR = 3.17, 95% CI [1.49–6.73]), and CHC patients (OR = 2.21, 95% CI [1.24–3.94]). HCV infection is a significant risk factor for developing T2DM. CHC, cirrhosis, and decompensated cirrhosis contribute to an increasingly greater risk of T2DM, but HCV clearance spontaneously or through clinical treatment may immediately reduce the risk of the onset and development of T2DM.
Published: 2019

11. The Intervention Effect of Traditional Chinese Medicine on the Intestinal Flora and Its Metabolites in Glycolipid Metabolic Disorders

Author: Linhua Zhao, Yingying Yang, Yitian Wang, Qi Bao, Lin Han, Xiaolin Tong, Sha Di, Zezheng Gao, and Qing Wang
Subjects: 0303 health sciences, Flora, Lipid disorder, business.industry, Intervention effect, Review Article, lcsh:Other systems of medicine, Disease, Traditional Chinese medicine, Pharmacology, lcsh:RZ201-999, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Glycolipid, Complementary and alternative medicine, 030220 oncology & carcinogenesis, Medicine, lipids (amino acids, peptides, and proteins), Metabolic syndrome, medicine.symptom, business, Abdominal obesity, 030304 developmental biology
Abstract: Metabolic syndrome (MS), which includes metabolic disorders such as protein disorder, glucose disorder, lipid disorder, and carbohydrate disorder, has been growing rapidly around the world. Glycolipid disorders are a main type of metabolic syndrome and are characterized by abdominal obesity and abnormal metabolic disorders of lipid, glucose, and carbohydrate utilization, which can cause cardiovascular and cerebrovascular diseases. Glycolipid disorders are closely related to intestinal flora and its metabolites. However, studies about the biological mechanisms of the intestinal flora and its metabolites with glycolipid disorders have not been clear. When glycolipid disorders are treated with drugs, a challenging problem is side effects. Traditional Chinese medicine (TCM) and dietary supplements have fewer side effects to treat it. Numerous basic and clinical studies have confirmed that TCM decoctions, Chinese medicine monomers, or compounds can treat glycolipid disorders and reduce the incidence of cardiovascular disease. In this study, we reviewed the relationship between the intestinal flora and its metabolites in glycolipid metabolic disorders and the effect of TCM in treating glycolipid metabolic disorders through the intestinal flora and its metabolites. This review provides new perspectives and strategies for future glycolipid disorders research and treatment.
Published: 2019

12. Efficacy and Safety of TangWang Prescription for Type 2 Non-Proliferative Diabetic Retinopathy: A Study Protocol for a Randomized Controlled Trial

Author: Qi Bao, Wenjing Huang, Meizhen Zhang, Xiang Meng, De Jin, Yuqing Zhang, Fengmei Lian, Yuehong Zhang, Qing Ni, Xiaolin Tong, Fan Yang, and Yanan Yang
Subjects: medicine.medical_specialty, 030209 endocrinology & metabolism, Placebo, law.invention, Hemangioma, Study Protocol, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Diabetes mellitus, medicine, Pharmacology (medical), protocol, Medical prescription, Macular edema, Pharmacology, business.industry, lcsh:RM1-950, Diabetic retinopathy, TangWang prescription, medicine.disease, Clinical trial, diabetic retinopathy, lcsh:Therapeutics. Pharmacology, traditional chinese medicine, randomized controlled trial, 030221 ophthalmology & optometry, business
Abstract: Background: Diabetic retinopathy (DR) is one of the most common and severe microvascular complications of diabetes mellitus (DM), which results in blindness among adults worldwide. Presently, the efficacy of drug treatments for diabetic retinopathy (DR) is not satisfactory, thus urgently necessitating effective drug treatment measures. TangWang prescription (TWP) has been found to have retinal protection effects in previous clinical and basic research. However, there is a lack of rigorous, randomized, and controlled studies. This study aims to evaluate the efficacy and safety of TWP in delaying the development of DR.Methods: This study is a randomized, double-blind, placebo-controlled, parallel-group, multicenter clinical trial, consisting of 384 participants to be randomized in a 1:1 ratio in the treatment and control groups. Furthermore, the treatment and control groups will be administered the TangWang prescription and the placebo, respectively, each at a dose of one bag twice a day. The study period will last for 48 weeks. The primary outcome measure will be the changes in the degree of retinal microvascular lesions before and after treatment. The secondary outcome will be changes in the degree of hemangioma, microvascular bleeding, microvascular leakage, macular edema, and vision. All statistical tests will be two-sided, and a p < 0.05 will be considered statistically significant.Discussion: We hypothesize that the patients with DR will benefit from TangWang prescription, and in addition to the central random system and platform of dynamic information collection, the patients’ conditions will be monitored, and the data collected for analysis. If successful, this study will provide evidence that the TWP formulation delays in the progression of DR.Trial registration: The design of this trial has been registered with the ClinicalTrials.gov (NCT03025399).
Published: 2021

13. The effectiveness of Baduanjin exercise for hypertension: a systematic review and meta-analysis of randomized controlled trials

Author: Xiatian Zhang, Qiuyi Lv, Qi Bao, Yao-yang Hou, Bao-yi Shao, Jianping Liu, Gordon H. Guyatt, Ying Zhang, Robin W.M. Vernooij, and Li-xing Lao
Subjects: medicine.medical_specialty, Blood Pressure, Subgroup analysis, 030204 cardiovascular system & hematology, Cochrane Library, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, medicine, Humans, 030212 general & internal medicine, Risk factor, Randomized Controlled Trials as Topic, Baduanjin, business.industry, Qigong, Public health, lcsh:Other systems of medicine, lcsh:RZ201-999, Meta-analysis, Blood pressure, Complementary and alternative medicine, Hypertension, Systematic review, Randomized controlled trials, Health education, business, Research Article
Abstract: Background Hypertension, a major risk factor of cardiovascular mortality, is a critical issue for public health. Although Baduanjin (Eight Brocades, EB), a traditional Chinese exercise, might influence blood pressure, glucose, and lipid status, the magnitude of true effects and subgroup differences remains unclear. Therefore, we performed a systematic review of relevant randomized controlled trials (RCTs) to evaluate the effect of EB on patient-important outcomes. Methods We systematically searched PubMed, the Cochrane Library, Web of Science, and Chinese databases since inception until March 30, 2020. Meta-analysis was carried out using “meta” package in R 3.4.3 software. A prespecified subgroup analysis was done according to the type of comparisons between groups, and the credibility of significant subgroup effects (P Results Our meta-analysis, including 14 eligible trials with 1058 patients, showed that compared with routine treatment or health education as control groups, the mean difference (MD) in systolic blood pressure (SBP) of the EB groups was − 8.52 mmHg (95%CI:[− 10.65, − 6.40], P P = 0.15; DBP P = 0.37), so it could be easily attributed to chance. Conclusion Regularly EB exercising may be helpful to control blood pressure, but the evidence is only low certainty for blood pressure and very low certainty for cardiovascular morbidity and mortality. Rigorously designed RCTs that carry out longer follow-up and address patient-important outcomes remain warranted. Trial registration PROSPERO Registration number: CRD42018095854.
Published: 2020

14. Plasma Ephrin-A1 level in a cohort of diabetic retinopathy patients

Author: Yukun Yang, Ying Jiang, Qi Bao, Kewei Wu, Danna Mao, Bo Lei, Ying Hu, and Yaoding Zheng
Subjects: medicine.medical_specialty, VEGF165, Gastroenterology, Cohort Studies, chemistry.chemical_compound, Plasma, lcsh:Ophthalmology, Internal medicine, Diabetes mellitus, medicine, Humans, Ephrin a1, Creatinine, Diabetic Retinopathy, business.industry, Ephrin-A1, General Medicine, Diabetic retinopathy, medicine.disease, Ophthalmology, chemistry, Diabetes Mellitus, Type 2, lcsh:RE1-994, Cohort, Mann–Whitney U test, Biomarker (medicine), ELISA, Analysis of variance, business, Biomarkers, Research Article
Abstract: Background To determine plasma ephrin-A1 and VEGF165 levels in a cohort of diabetic retinopathy patients. Methods Plasma ephrin-A1 and VEGF165 levels in fifty-five subjects including 19 individuals without diabetes (non-DM), 16 patients with diabetes (DM) but without diabetic retinopathy, and 20 patients with diabetic retinopathy (DR), were determined by ELISA. Serum creatinine, total cholesterol, fasting blood glucose and HbA1c were also measured. One-way ANOVA, Kruskal-Wallis Test, Mann-Whitney U Test corrected by Bonferroni, Pearson Correlation Analysis and Spearman Correlation Coefficient Analysis were used for data analysis. Results Ephrin-A1 expression could be detected in human plasma with an average of 1.52 ± 0.43 (mean ± SEM) ng/ml. In DR subjects, the plasma ephrin-A1concentration was 3.63 ± 4.63 ng/ml, which was significantly higher than that of the other two groups (non-DM: 0.27 ± 0.13 ng/ml, DM: 0.35 ± 0.34 ng/ml). The expression of VEGF165 in human plasma was 34.00 ± 42.55 pg/ml, with no statistical difference among the three groups. There was no correlation between ephrin-A1 and VEGF165 in human plasma, but there was a correlation between plasma ephrin-A1 and duration of diabetes. Conclusions Plasma ephrin-A1 was highly expressed in patients with diabetic retinopathy, and there was no difference of plasma VEGF165 expression in patients with diabetic retinopathy compared to the other two groups, suggesting that changes of plasma ephrin-A1 may be a more sensitive biomarker than plasma VEGF165 in detecting diabetic retinopathy.
Published: 2020

15. Autoimmune polyendocrine syndrome induced by immune checkpoint inhibitors: a systematic review

Author: Dan Zhang, Meiyu Shang, Xiu-Qi Bao, Xinfeng Wang, Jingwen Ning, and Zhe Zhao
Subjects: Cancer Research, medicine.medical_specialty, Immunology, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Neoplasms, medicine, Immunology and Allergy, Endocrine system, Humans, Adverse effect, Polyendocrinopathies, Autoimmune, Immune Checkpoint Inhibitors, business.industry, Thyroid, Autoantibody, Cancer, medicine.disease, Prognosis, medicine.anatomical_structure, Oncology, Autoimmune polyendocrine syndrome, business, 030215 immunology, Hormone
Abstract: To summarize the clinical characteristics and immunological and genetic features of patients who developed autoimmune polyendocrine syndrome type II (APS-2) after treatment with immune checkpoint inhibitors (ICIs). Several databases (MEDLINE/EMBASE/Cochrane) were searched for studies published between January 2000 and February 2020 involving patients with two or more endocrine disorders after ICI therapy. Our final review included 22 articles comprising 23 patients (median age 56 years; 65.2% male patients). Of these patients, 60.9% received anti-programmed cell death 1 (PD-1) therapy, 17.4% received anti-programmed cell death ligand 1 (PD-L1) therapy, and 4.3% received anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monotherapy. Patients underwent a median of four treatment cycles before the onset of the primary adverse event; the median time of onset was 8.5 weeks. Endocrine organs affected by ICI administration included the thyroid gland (18/23, 78.3%), pancreatic islets (17/23, 73.9%), pituitary gland (11/23, 47.8%), and adrenal gland (2/23, 8.7%). Related autoantibodies were detected in 65.2% of patients. In patients with diabetes, glutamic acid decarboxylase antibody was closely related to the development of diabetes ketoacidosis. The human leukocyte antigen genotype was reported in 34.8% (8/23) of patients, 5 (62.5%) of which had risk genotypes. As a serious adverse event of ICI treatment, APS-2 is presented with abrupt initiation time and rapid development. Physicians should be aware of potential endocrine disorders and continue monitoring hormone status when treating cancer patients with ICIs.
Published: 2020

16. Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson’s Disease Models

Author: Lu Wang, Yue Wang, Junmei Shang, Zihong Zhang, Caixia Zang, Xiu-Qi Bao, Dan Zhang, Xiaoliang Wang, Hanyu Yang, and Hui Liu
Subjects: 0301 basic medicine, microglia, Microgliosis, Neuroprotection, lcsh:RC321-571, neuroinflammation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Neuroinflammation, Original Research, Microglia, business.industry, General Neuroscience, MPTP, Neurodegeneration, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, chemistry, Cancer research, Parkinson’s disease, neuroprotection, business, Tyrosine kinase, 030217 neurology & neurosurgery, Proto-oncogene tyrosine-protein kinase Src, Neuroscience, Src
Abstract: Chronic neuroinflammation is of great importance in the pathogenesis of Parkinson's disease (PD). During the process of neuroinflammation, overactivated microglia release many proinflammatory factors, which eventually induce neurodegeneration. Inhibition of excessive microglial activation is regarded as a promising strategy for PD treatment. Src is a non-receptor tyrosine kinase that is closely related to tumors. Recently, some reports indicated that Src is a central mediator in multiple signaling pathways including neuroinflammation. The aim of our study was to demonstrate the role of Src in microglial regulation and neuroinflammation. The lipopolysaccharide (LPS)-stimulated BV2 microglia model and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model were applied in this study. The results showed that inhibition of Src could significantly relieve microgliosis and decrease levels of inflammatory factors. Besides, inhibition of Src function reduced the loss of dopaminergic neurons and improved the motor behavior of the MPTP-treated mice. Thus, this study not only verified the critical role of Src tyrosine kinase in neuroinflammation but also further proved that interfering neuroinflammation is beneficial for PD treatment. More importantly, this study shed a light on the hypothesis that Src tyrosine kinase might be a potential therapeutic target for PD and other neuroinflammation-related diseases.
Published: 2020

17. ACT001 can prevent and reverse tamoxifen resistance in human breast cancer cell lines by inhibiting NF‐κB activation

Author: Yong Sheng Jia, Shi Qi Bao, Ye Hui Shi, Wen Ping Lu, Xiao Han Jin, Zhong Sheng Tong, and Qiu Ying Li
Subjects: 0301 basic medicine, Drug, medicine.drug_class, media_common.quotation_subject, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, medicine, skin and connective tissue diseases, Molecular Biology, Gene, media_common, business.industry, Cell Biology, medicine.disease, 030104 developmental biology, Apoptosis, Estrogen, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Signal transduction, business, hormones, hormone substitutes, and hormone antagonists, Tamoxifen, medicine.drug
Abstract: Endocrine therapy is one of the main treatments for estrogen receptor-positive breast cancers. Tamoxifen is the most commonly used drug for endocrine therapy. However, primary or acquired tamoxifen resistance occurs in a large proportion of breast cancer patients, leading to therapeutic failure. We found that the combination of tamoxifen and ACT001, a nuclear factor-κB (NF-κB) signaling pathway inhibitor, effectively inhibited the proliferation of both tamoxifen-sensitive and tamoxifen-resistant cells. The tamoxifen-resistant cell line MCF7R/LCC9 showed active NF-κB signaling and high apoptosis-related gene transcription, especially for antiapoptotic genes, which could be diminished by treatment with ACT001. These results demonstrate that ACT001 can prevent and reverse tamoxifen resistance by inhibiting NF-κB activation.
Published: 2018

18. Chinese herbal medicine Tangshen Formula treatment for type 2 diabetic kidney disease in the early stage: study protocol for a randomized controlled trial

Author: Fengmei Lian, De Jin, Wenjing Huang, Meizhen Zhang, Qi Bao, Xiang Meng, Xiaolin Tong, Fan Yang, Qing Ni, and Ya-nan Yang
Subjects: Male, Medicine (miscellaneous), Type 2 diabetes, Kidney, law.invention, Placebos, chemistry.chemical_compound, Study Protocol, 0302 clinical medicine, Randomized controlled trial, law, Prevalence, Pharmacology (medical), Diabetic Nephropathies, Medicine, Chinese Traditional, lcsh:R5-920, 0303 health sciences, Proteinuria, Middle Aged, Treatment Outcome, 030220 oncology & carcinogenesis, Female, medicine.symptom, lcsh:Medicine (General), Glomerular Filtration Rate, Adult, medicine.medical_specialty, China, Renal function, Placebo, Losartan, 03 medical and health sciences, Traditional Chinese medicine, Double-Blind Method, Internal medicine, medicine, Albuminuria, Humans, Diabetic kidney disease, Antihypertensive Agents, 030304 developmental biology, Aged, Creatinine, business.industry, medicine.disease, Treatment, Early Diagnosis, chemistry, Case-Control Studies, Microalbuminuria, business, Kidney disease, Drugs, Chinese Herbal
Abstract: Background Diabetic kidney disease (DKD) is the main cause of end-stage kidney disease and has become a heavy economic and social burden due to its high prevalence and morbidity. The most effective strategy is that patients with DKD should be diagnosed and treated early. Preliminary studies showed that the Chinese herbal Tangshen Formula (TSF) may delay the progression of DKD, reducing microalbuminuria and macroalbuminuria and improving renal function. We designed a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of TSF in patients with DKD. Methods/design This trial is a 13-center, randomized, double-blind, placebo-controlled study. A total of 632 participants will be randomized in a 1:1 ratio to an experiment group (TSF plus losartan) and a control group (placebo plus losartan). The trial cycle will last 24 weeks. The primary outcome will be the change in the urine microalbumin–creatinine ratio from baseline to week 24. The secondary outcome will be the change in the rate of progression to the clinical proteinuria period after intervention, the rate of urine microalbumin negative conversion, the rate of normal urinary microalbumin, the doubling rate of the baseline creatinine value and the glomerular filtration rate between the two groups. Safety in medication will also be evaluated. Discussion We hypothesize that patients with type 2 diabetes in the early stage of DKD will benefit from TSF. If successful, this study will provide evidence-based recommendations for clinicians. Trial registration ClinicalTrials.gov, NCT03009864. Registered January 2017.
Published: 2019

19. IL-33 attenuates mortality by promoting IFN-γ production in sepsis

Author: Qi Bao, Min Lei, and Ran Lv
Subjects: 0301 basic medicine, Allergy, medicine.medical_specialty, Immunology, Sepsis, Interferon-gamma, 03 medical and health sciences, High morbidity, 0302 clinical medicine, Internal medicine, medicine, Animals, Interferon gamma, Intraepithelial Lymphocytes, Mice, Knockout, Pharmacology, business.industry, Interleukin, Interleukin-33, medicine.disease, Rheumatology, Inflammatory mediator, Killer Cells, Natural, Mice, Inbred C57BL, Interleukin 33, 030104 developmental biology, 030220 oncology & carcinogenesis, business, medicine.drug
Abstract: Sepsis remains a major clinical problem with high morbidity and mortality. Interleukin (IL)-33 is a recently described member of the IL-1 family that is widely expressed and functions as a new inflammatory mediator. IL-33 has been reported to protect sepsis, but the underlying mechanisms are not well-elucidated. We measured the interferon gamma (IFN-γ) production in septic mice after IL-33 treatment. IL-33 treatment enhanced the IFN-γ level in blood and promoted mice’s survival, so the protective effects of IL-33 depend on IFN-γ. The IL-33 treatment also promoted both γδ T cells and NK cells in septic mice. Our data showed that IL-33 attenuates mortality by promoting IFN-γ production in sepsis.
Published: 2018

20. The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity

Author: Yang Yu, Xin-Sheng Yao, Lu Wang, Xiaoliang Wang, Caixia Zang, Hanyu Yang, Dan Zhang, Lin Li, and Xiu-Qi Bao
Subjects: Male, 0301 basic medicine, Traditional Chinese medicine, Gardenia jasminoides, Pharmacology, Neuroprotection, Antioxidants, Crocin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Memory, Animals, Learning, Medicine, Memory impairment, Cognitive Dysfunction, Neuroinflammation, Mice, Inbred ICR, Amyloid beta-Peptides, biology, Plant Extracts, business.industry, Neurotoxicity, General Medicine, Gardenia, biology.organism_classification, medicine.disease, Carotenoids, Peptide Fragments, Disease Models, Animal, 030104 developmental biology, Complementary and alternative medicine, chemistry, Fruit, business, 030217 neurology & neurosurgery, Phytotherapy
Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. Although the exact causes of AD have not yet been fully elucidated, cholinergic dysfunction, mitochondrial damage, oxidative stress and neuroinflammation have been recognized as influential factors. Current drugs that are designed to address only a single target are unable to mitigate or prevent the progression of this complicated disease, so new disease-modifying drugs are urgently needed. Chinese herbs with thousand years of effective usage might be a good source for potential drugs. Gardenia jasminoides J. Ellis (Fructus Gardenia) is a common traditional Chinese medicine with tranquilizing effects, which is an important component of widely-used traditional Chinese medicine for dementia. GJ-4 is crocin richments extracted from Gardenia jasminoides J. Ellis. In our study, we attempted to observe the effects of GJ-4 on learning and memory injury induced by amyloid-[Formula: see text] 25-35 (A[Formula: see text] injection in mice. Treatment with GJ-4 dose-dependently enhanced the memory and cognition ability of A[Formula: see text]-injected mice. Preliminary mechanistic studies revealed the protective effect of GJ-4 was related to its protection of neurons and cholinergic dysfunction. The mechanistic results also indicated that GJ-4 could enhance antioxidant capacity and attenuate neuroinflammation. Our results implied that GJ-4 might be a promising drug to improve cognitive and memory impairment, with multiple targets.
Published: 2018

21. Using multi-site substitution to design blue-exciting phosphor Mg2Y2Al2Si2O12:Mn2+ for full-spectrum plant growth LEDs

Author: Zhipeng Wang, Qi Bao, Zhijun Wang, Panlai Li, JinjinLiu, Zhiping Yang, Yuebin Li, Keliang Qiu, and Xiangyu Meng
Subjects: Materials science, business.industry, Doping, Biophysics, Phosphor, 02 engineering and technology, General Chemistry, Green-light, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Chip, 01 natural sciences, Biochemistry, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Ion, law.invention, Crystal, law, Excited state, Optoelectronics, 0210 nano-technology, business, Light-emitting diode
Abstract: Full-spectrum plant growth light emitting diode (LED) prepared using a variety of phosphors has some problems, such as energy loss and spectral distortion. It is the solution that designing a kind of phosphor, which is the single activated ion doped phosphor with the multiple emission. To achieve this goal, the host Mg2Y2Al2Si2O12 (Abbreviated as: MYASO) was selected from a large number of garnet materials which has the multi-sites, and the Mn2+ was selected as the activated ion which can produce the different emission in the different crystal field. The results show that Mn2+ can produce the green light (536 nm), red light (635 nm) and deep red light (735 nm), which correspond to the Mn2+ substituting for the tetra-coordinated Al3+, the octa-coordinated Mg2+ and the hexa-coordinated Mg2+, respectively, importantly, this phosphor can be efficiently excited by the 456 nm blue light, which matches well with the blue LED chip. Therefore, it may be a great potential application value in the production of plant growth LEDs.
Published: 2021

22. Active vibration control of large space flexible slewing truss using cable actuator with input saturation

Author: Qi-Bao Jin and Jin Huang
Subjects: 0209 industrial biotechnology, Engineering, business.industry, Mechanical Engineering, General Chemical Engineering, 0211 other engineering and technologies, Biomedical Engineering, Aerospace Engineering, Truss, Control engineering, 02 engineering and technology, Industrial and Manufacturing Engineering, Vibration, Nonlinear system, 020901 industrial engineering & automation, Control and Systems Engineering, Linearization, Control theory, Active vibration control, Piecewise, Electrical and Electronic Engineering, business, Actuator, 021101 geological & geomatics engineering
Abstract: Summary This paper proposes a composite approach to implementing attitude tracking and active vibration control of a large space flexible truss system. The system dynamic model is based on Hamilton's principle and discretized using the finite difference method. A nonlinear attitude controller for position tracking is developed based on the input-output linearization of the discretized system, which can effectively improve system performance compared with a traditional proportional-differential feedback controller. A taut cable actuator scheme is presented to suppress tip vibration because the mechanical model is a large large-span spatial structure; furthermore, because the cable has the feature of unilateral input saturation constraint, which can provide only a pulling force, a nonlinear quadratic regulator controller is developed by introducing a piecewise nonquadratic cost function to suppress the vibration of the flexible structure. To investigate the factors that influence the damping effects of the cable, the parametrically excited instability of a cable under 2 supports is analyzed. Simulation results illustrate that the proposed attitude controller can implement the task of position tracking, and the vibration suppression control law is shown to be optimal for functional performance with input saturation.
Published: 2017

23. The modified Yi qi decoction protects cardiac ischemia-reperfusion induced injury in rats

Author: Xiao Yu, Guo-Xing Zhang, Xiao-Dong Zhao, Rong-Qi Bao, Jing-Wei Chen, and Jia-Yu Yu
Subjects: 0301 basic medicine, Cardiac function curve, Male, medicine.medical_specialty, Cardiac ischemia-reperfusion, Qi, Modified Yi qi decoction (MYQ), Myocardial Ischemia, Decoction, Myocardial Reperfusion Injury, Apoptosis, Sodium-Calcium Exchanger, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Autophagy, Animals, Humans, Calcium handling proteins, Sodium-calcium exchanger, business.industry, Endoplasmic reticulum, Therapeutic effect, General Medicine, lcsh:Other systems of medicine, lcsh:RZ201-999, Arterial occlusion, Surgery, Rats, Cytosol, 030104 developmental biology, Endocrinology, Complementary and alternative medicine, 030220 oncology & carcinogenesis, cardiovascular system, Beclin-1, business, Drugs, Chinese Herbal, Research Article
Abstract: Background To investigate the effects and involved mechanisms of the modified Yi Qi decoction (MYQ) in cardiac ischemia-reperfusion (IR) induced injury. Methods Male Sprague-Dawley rats were subjected to a 30-min coronary arterial occlusion followed by reperfusion, low or high dose decoction of MYQ was administrated orally for 1 week or 1 month. Results Both in 1 week and 1 month IR rat groups, cardiac function indexes were significantly impaired compared with sham group rats, accompanied with higher ratio of infarct size to risk size, decreased expressions of sodium calcium exchanger (NCX1) and sarcoplasmic reticulum Ca2+-ATPase (Serca2a), and different expressions of autophagic proteins, Beclin-1 and LC3. Treatment with MYQ (low or high dose) for 1 week showed no marked beneficial effects on cardiac function and cardiac injury (ratio of infarct size to risk size), although expressions of anti-apoptotic protein, Bcl-2, NCX1 and Serca2a were increased. Treatment with MYQ (low or high dose) for 1 month showed significantly improved effects on cardiac function and cardiac injury (ratio of infarct size to risk size), accompanied with increase of Bcl-2, NCX1 and Serca2a expressions, and decrease of Bax (a pro-apoptotic protein) and Beclin-1 expressions. Conclusions The results show that MYQ have potential therapeutic effects on IR-induced cardiac injury, which may be through regulation of apoptotic proteins, cytosolic Ca2+ handling proteins and autophagic proteins signal pathways.
Published: 2017

24. Establishment of a new acute-on-chronic liver failure model

Author: Xiu-Qi Bao, Hua Sun, Dan Zhang, Yu-Yang Zhang, Lu-Yang Miao, and Fangfang Li
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Necrosis, Cirrhosis, Porcine serum, Lipopolysaccharide, Bilirubin, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, Internal medicine, ACLF, medicine, General Pharmacology, Toxicology and Pharmaceutics, Liver injury, TUNEL assay, business.industry, lcsh:RM1-950, medicine.disease, d-Galactosamine, 030104 developmental biology, Endocrinology, lcsh:Therapeutics. Pharmacology, chemistry, Apoptosis, Rat, 030211 gastroenterology & hepatology, Original Article, medicine.symptom, business
Abstract: To establish an animal model of acute-on-chronic liver failure (ACLF) that would replicate the pathological process of ACLF in humans, rats were administered porcine serum (PS) for 11 weeks. Liver fibrosis was determined by pathological and biochemical assessments. The animals then were injected with d-galactosamine (d-gal) and lipopolysaccharide (LPS). The survival times of animals with cirrhosis and ACLF were determined over 48 h. Other animals were killed at 0, 4, 8 and 12 h after administration of d-gal/LPS. Liver injury was assessed by histopathological analysis and biochemical indices, and apoptosis was detected by Western blot and TUNEL analysis. After PS administration for 11 weeks the serum levels of hyaluronic acid and N-procollagen type III peptide increased significantly, and serious fibrosis and cirrhosis was observed at weeks 10 and 11. Cirrhotic rats were injected with d-gal/LPS to induced ACLF; the rate of mortality over 48 h was 80%. ALT and AST levels increased markedly at 4 h, but decreased significantly at 8 and 12 h post-treatment. The total bilirubin, direct bilirubin, and total bile acids levels increased markedly at 8 and 12 h. Clotting times, TNF-α and IL-6 levels increased significantly, except for 12 h post-treatment. Apoptosis, inflammation and necrosis were elevated as determined by hematoxylin-eosin staining and TUNEL assays. BCL-2 levels decreased significantly, While BAX levels increased significantly. Cytochrome c expression peaked at 8 h post-d-gal/LPS treatment. In conclusion, an ACLF model induced by PS and d-gal/LPS was established and the underlying mechanisms of ACLF development were explored., Graphical abstract A rat acute-on-chronic liver failure (ACLF) model induced by porcine serum and d-galactosamine/lipopolysaccharide was established and underlying mechanisms of ACLF development were explored.fx1
Published: 2017

25. A novel concentrator with zero-index metamaterial for space solar power station

Author: Qi-Bao Jin, Xue-mei Chu, Zhu-zhu Duan, Jian-yu Fan, and Jin Huang
Subjects: Physics, Atmospheric Science, Power transmission, business.industry, Photovoltaic system, Electrical engineering, Aerospace Engineering, Astronomy and Astrophysics, 02 engineering and technology, Space-based solar power, 021001 nanoscience & nanotechnology, Concentrator, Solar energy, 01 natural sciences, Geophysics, Optics, Electricity generation, Space and Planetary Science, 0103 physical sciences, Geostationary orbit, General Earth and Planetary Sciences, 010306 general physics, 0210 nano-technology, business, Solar power
Abstract: Space solar power station (SSPS) is a comprehensive system that continuously collects solar energy in space and transmits it to ground with a wireless power transmission (WPT) system. These systems have great potential to provide large-scale energy. To increase the efficiency and reduce the weight and cost of the photovoltaic (PV) components, a huge light-weighted concentrator was introduced in the latest SSPS concepts, such as integrated symmetrical concentrator (ISC) and arbitrarily large phased array (ALPHA). However, for typical SSPS running in Geostationary Earth Orbit (GEO), the sunlight direction varies with time, leading to a great challenge for concentrator design. In ISC, the two-dimensional mast is used to realize sun-tracking. However, a multi-thousand-ton structure is difficult to control precisely in space. For this reason, ALPHA comprises a large number of individually pointed thin-film reflectors to intercept sunlight, mounted on the non-moving structure. However, the real-time adjustment of the thousands of reflectors is still an open problem. Furthermore, the uniformity of the time of the power generation (UTPG) is another factor evaluating the system. Therefore, this paper proposes a novel concentrator based on zero-index metamaterial (ZIM) called Thin-film Energy Terminator (SSPS-TENT). This will aid the control of the massive reflectors while avoiding the rotation of the overall system, the control of the massive reflectors and the influence of the obliquity of the ecliptic. Also, an optimization design method is proposed to increase its solar energy collecting efficiency (ECE) and flux distribution (FD). The ray-tracing simulation results show that the ECE is more than 96% of the day. In terms of the FD, the uniformity varies from 0.3057 to 0.5748. Compared with ALPHA, the UTPG is more stable.
Published: 2017

26. Novel Phloroglucinol Derivative Compound 21 Protects Experimental Autoimmune Encephalomyelitis Rats via Inhibiting Th1/Th17 Cell Infiltration

Author: Zhe Zhao, Hui Liu, Xiu-Qi Bao, Zihong Zhang, Dan Zhang, and Fangyuan Li
Subjects: Autoimmune disease, education.field_of_study, business.industry, Multiple sclerosis, Experimental autoimmune encephalomyelitis, Population, Inflammation, medicine.disease, Neuroprotection, Myelin, medicine.anatomical_structure, Immunology, medicine, medicine.symptom, business, education, Infiltration (medical)
Abstract: Multiple Sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory infiltration and demyelination in the central nervous system (CNS). Among all the factors that are involved in the immunological mechanisms of MS, T helper 1 (Th1) cells and T helper 17 (Th17) cells play a critical role. Compound 21, a novel phloroglucinol derivative, has shown remarkable effects on protecting myelin damage in our previous study. However, whether it has effects on MS remains unclear. In this study, the experimental autoimmune encephalomyelitis (EAE) rat model was established to mimic the pathological process of MS and to evaluate the neuroprotective effect of Compound 21. The results illustrated that Compound 21 treatment notably attenuated the neurological deficits, immune infiltration and demyelination of EAE rats. Mechanistic investigation revealed that Compound 21 treatment reduced the population of Th1/Th17 cells and inhibited their infiltration into the CNS. Further study found that the inhibition of Th1/Th17 cell infiltration was related to the direct suppression of Th1/Th17 cell differentiation and inhibition of pro-inflammatory microglial cells. Collectively, all these results proved that Compound 21 treatment suppressed infiltrated Th1/Th17 cells to alleviate the demyelination of EAE rats, suggesting its potential role as a novel candidate for MS treatment. Funding Statement: This investigation was supported by grants from National Sciences Foundation of China (81630097, 81773718), CAMS Innovation Fund for Medical Sciences (No. 2016-I2M-3-011), CAMS The Fundamental Research Funds for the Central Universities (2018RC350002), National Major Scientific and Technological Special Project for “Significant New Drugs Development” during the Thirteenth Five-year Plan Period (2018ZX09711001-003-005, 2018ZX09711001-008-005, 2018ZX09711001-003-020). Declaration of Interests: The authors declare no competing financial or other interests. Ethics Approval Statement: All the animal experiments were carried out according to the guidelines of the Beijing Municipal Ethic Committee for the care and use of laboratory animals.
Published: 2019

27. The efficacy of pregabalin for the management of acute and chronic postoperative pain in thoracotomy: a meta-analysis with trial sequential analysis of randomized-controlled trials

Author: Min Lei, Yijin Yu, Qi Bao, Jin-ning Zhao, Junran Xie, Nan Liu, Qingxin Zeng, and Jing Duan
Subjects: Nausea, Analgesic, Pregabalin, thoracotomy, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, 030202 anesthesiology, law, Medicine, 030212 general & internal medicine, Journal of Pain Research, Original Research, neuropathic pain, business.industry, Clinical trial, meta-analysis, Regimen, Anesthesiology and Pain Medicine, Anesthesia, Neuropathic pain, Vomiting, pregabalin, medicine.symptom, business, postoperative pain, medicine.drug
Abstract: Yijin Yu,1 Nan Liu,2 Qingxin Zeng,3 Jing Duan,1 Qi Bao,1 Min Lei,1 Jinning Zhao,1 Junran Xie1 1Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China; 2Department of Anesthesiology, Hangzhou Xiasha Hospital, Zhejiang, China; 3Department of Thoracic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, China Purpose: Pregabalin is commonly used as an analgesic for neuropathic pain. But pregabalin as an adjunct to a multimodal analgesic regimen – although standard clinical protocol in some settings – has remained controversial. This meta-analysis was conducted to identify the efficacy of pregabalin for management of postoperative pain in thoracotomy.Materials and methods: Pubmed, Embase, Cochrane, Web of Science, Springer, and Clinical Trial Register database were searched for randomized controlled trials (RCTs) of pregabalin in preventing postoperative pain in thoracotomy. Review Manager 5.3 and STATA 12.0 were selected to conduct the meta-analysis. Trial sequential analysis was used to control random errors and calculate the required information size.Results: Nine RCTs with 684 patients were included in our meta-analysis. Outcomes favoring pregabalin included less pain on a 0–10 scale on 1 day [mean difference (MD): –0.87; 95% CI: –1.55 to –0.19; P=0.01], 3 days (MD: –1.55; 95% CI: –1.93 to –1.18; P
Published: 2018

28. Strain‐Modulated Light Emission Properties in a Single InGaN/GaN Multiple‐Quantum‐Well Microwire‐Based Flexible Light‐Emitting Diode

Author: Chuan Cheng, Xingjun Luo, Shuti Li, Qing Liu, Jiaqi Guo, He Longfei, Fangliang Gao, Yuqing Yang, Qi-Bao Wu, Weidong Song, and Jiang Shi
Subjects: Materials science, Strain (chemistry), business.industry, law, Multiple quantum, Optoelectronics, General Materials Science, Light emission, Condensed Matter Physics, business, Light-emitting diode, law.invention
Published: 2021

29. GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation

Author: Yang Yu, Hui Liu, Xiu-Qi Bao, Zihong Zhang, Fang-Yu Yuan, Dan Zhang, Lu Wang, Hanyu Yang, Junmei Shang, Chanjuan Sheng, Caixia Zang, Xin-Sheng Yao, and Zhe Zhao
Subjects: Male, Ischemia, Morris water navigation task, Pharmacology, Neuroprotection, Rats, Sprague-Dawley, Brain ischemia, 03 medical and health sciences, 0302 clinical medicine, Memory, Drug Discovery, medicine, Animals, Nimodipine, Nootropic Agents, Neuroinflammation, 030304 developmental biology, Memory Disorders, 0303 health sciences, Behavior, Animal, Microglia, biology, Plant Extracts, business.industry, Dementia, Vascular, Brain, Infarction, Middle Cerebral Artery, Janus Kinase 2, Gardenia, medicine.disease, Disease Models, Animal, Neuroprotective Agents, STAT1 Transcription Factor, medicine.anatomical_structure, Reperfusion Injury, 030220 oncology & carcinogenesis, Synapses, Synaptophysin, biology.protein, Inflammation Mediators, business, Drugs, Chinese Herbal, Signal Transduction, medicine.drug
Abstract: Ethnopharmacological relevance Gardenia jasminoides J. Ellis (Fructus Gardenia) is a traditional Chinese medicine with diverse pharmacological functions, such as anti-inflammation, anti-depression, as well as improvement of cognition and ischemia brain injury. GJ-4 is a natural extract from Gardenia jasminoides J. Ellis (Fructus Gardenia) and has been proved to improve memory impairment in Alzheimer's disease (AD) mouse model in our previous studies. Aim of the study This study aimed to evaluate the therapeutic effects of GJ-4 on vascular dementia (VD) and explore the potential mechanisms. Material and methods In our experiment, a focal cerebral ischemia and reperfusion rat model was successfully developed by the middle cerebral artery occlusion and reperfusion (MCAO/R). GJ-4 (10 mg/kg, 25 mg/kg, 50 mg/kg) and nimodipine (10 mg/kg) were orally administered to rats once a day for consecutive 12 days. Learning and memory behavioral performance was assayed by step-down test and Morris water maze test. The neurological scoring test was performed to evaluate the neurological function of rats. 2,3,5-Triphenyltetrazolium chloride (TTC) staining and Nissl staining were respectively employed to determine the infarct condition and neuronal injury of the brain. Iba1 immunohistochemistry was used to show the activation of microglia. Moreover, the synaptic damage and inflammatory level were detected by Western blot. Results GJ-4 could significantly improve memory impairment, cerebral infraction, as well as neurological deficits of VD rats induced by MCAO/R. Further research indicated VD-induced neuronal injury was alleviated by GJ-4. In addition, GJ-4 could protect synapse of VD rats by upregulating synaptophysin (SYP) expression, post synaptic density 95 protein (PSD95) expression, and downregulating N-Methyl-D-Aspartate receptor 1 (NMDAR1) expression. Subsequent investigation of the underlying mechanisms identified that GJ-4 could suppress neuroinflammatory responses, supported by inhibited activation of microglia and reduced expression of inflammatory proteins, which ultimately exerted neuroprotective effects on VD. Further mechanistic study indicated that janus kinase 2 (JAK2)/signal transducer and activator of transcription 1 (STAT1) pathway was inhibited by GJ-4 treatment. Conclusion These results suggested that GJ-4 might serve as a potential drug to improve VD. In addition, our study indicated that inhibition of neuroinflammation might be a promising target to treat VD.
Published: 2021

30. The Role of IL-33 on LPS-Induced Acute Lung Injury in Mice

Author: Qi Bao, Yv Sun, Dongju Xiao, Junran Xie, Xuming Hu, Yaping Zhang, Jinning Zhao, Li Jiang, and Ran Lv
Subjects: Lipopolysaccharides, 0301 basic medicine, Pathology, medicine.medical_specialty, Acute Lung Injury, Immunology, Lung injury, Pharmacology, Proinflammatory cytokine, Capillary Permeability, Mice, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Pulmonary fibrosis, medicine, Animals, Immunology and Allergy, Lung, Inflammation, biology, medicine.diagnostic_test, business.industry, respiratory system, Interleukin-33, Pulmonary edema, medicine.disease, respiratory tract diseases, Mice, Inbred C57BL, Survival Rate, 030104 developmental biology, Bronchoalveolar lavage, medicine.anatomical_structure, Myeloperoxidase, biology.protein, Cytokines, Mitogen-Activated Protein Kinases, business, Bronchoalveolar Lavage Fluid, 030215 immunology
Abstract: The objective of the study is to investigate the role and specific molecular mechanism of interleukin-33 (IL-33) acted on acute lung injury (ALI) induced by lipopolysaccharide (LPS). C57BL/6 mice intratracheally instilled LPS to induce ALI model. The mice were randomly divided into three groups: the sham operation group (Sham), ALI group (ALI), and pretreatment with IL-33 of ALI group (IL-33). By observing the survival rate, inflammatory cytokines in bronchoalveolar lavage fluid (BALF), myeloperoxidase (MPO) levels in lung tissue, lung histopathological examination, pulmonary capillary leakage, lung wet/dry (W/D) weight ratio, fibrosis levels in lung tissue, and associated pathways changes among the different groups, comparing to explore the role of IL-33 pretreatment on ALI mice and the possible molecular mechanisms. IL-33 pretreatment overall decreased the survival rate of ALI mice. IL-33 aggravated inflammation reaction showing as increasing the release of proinflammatory cytokines TNF-α and IL-6, increasing MPO levels in lung tissue, and aggravating lung pathology injury. In addition, IL-33 pretreatment further destroyed adherens junctions (AJs) by increasing the phosphorylation of VE-cadherin, resulting in the concomitantly pulmonary capillary barrier damage and pulmonary edema. During this process, mitogen-activated protein kinase (MAPK) pathways further activated. However, IL-33 pretreatment had no significant impact on collagen content of lung tissue. Our results indicated that IL-33 aggravated inflammatory reaction and increased microvascular permeability, but had little effect on pulmonary fibrosis, associated with the further activation of MAPK family proteins in the process. To sum up, IL-33 decreased survival rate and aggravated LPS-induced ALI.
Published: 2016

31. A Tensor Neural Network with Layerwise Pretraining: Towards Effective Answer Retrieval

Author: Xin-Qi Bao and Yunfang Wu
Subjects: Computer Science::Machine Learning, Word embedding, Tensor product network, Computer science, 02 engineering and technology, 010501 environmental sciences, Machine learning, computer.software_genre, 01 natural sciences, Theoretical Computer Science, Robustness (computer science), Tensor (intrinsic definition), 0202 electrical engineering, electronic engineering, information engineering, Question answering, Relevance (information retrieval), Tensor, 0105 earth and related environmental sciences, Artificial neural network, business.industry, Autoencoder, Computer Science Applications, Computational Theory and Mathematics, Hardware and Architecture, 020201 artificial intelligence & image processing, Artificial intelligence, business, computer, Software
Abstract: In this paper we address the answer retrieval problem in community-based question answering. To fully capture the interactions between question-answer pairs, we propose an original tensor neural network to model the relevance between them. The question and candidate answers are separately embedded into different latent semantic spaces, and a 3-way tensor is then utilized to model the interactions between latent semantics. To initialize the network layers properly, we propose a novel algorithm called denoising tensor autoencoder (DTAE), and then implement a layerwise pretraining strategy using denoising autoencoders (DAE) on word embedding layers and DTAE on the tensor layer. The experimental results show that our tensor neural network outperforms various baselines with other competitive neural network methods, and our pretraining DTAE strategy improves the system’s performance and robustness.
Published: 2016

32. Bicyclol promotes toll-like 2 receptor recruiting inosine 5′-monophosphate dehydrogenase II to exert its anti-inflammatory effect

Author: You-Wen Zhang, Hua Sun, Dan Zhang, Yan-Shen Guo, and Xiu-Qi Bao
Subjects: Lipopolysaccharides, 0301 basic medicine, medicine.medical_treatment, Interleukin-1beta, Anti-Inflammatory Agents, Pharmaceutical Science, Pharmacology, Peripheral blood mononuclear cell, Analytical Chemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, IMP Dehydrogenase, Drug Discovery, medicine, Animals, Humans, Inosine-5′-monophosphate dehydrogenase, Inosine, Receptor, Molecular Structure, biology, Tumor Necrosis Factor-alpha, business.industry, Biphenyl Compounds, Organic Chemistry, NF-kappa B, NF-κB, General Medicine, Toll-Like Receptor 2, Molecular Docking Simulation, TLR2, 030104 developmental biology, Cytokine, Complementary and alternative medicine, chemistry, Concanavalin A, Immunology, Leukocytes, Mononuclear, biology.protein, Molecular Medicine, business, Signal Transduction, medicine.drug
Abstract: The aim was to investigate potential targets and anti-inflammatory mechanisms of bicyclol, which has been extensively used in clinic for decades in China. Tar-Fis-Dock, virtual molecular docking system, showed that inosine 5'-monophosphate dehydrogenase II (IMPDH II) has the highest probability of binding to bicyclol. To investigate the possible role of IMPDH II in mechanisms of bicyclol, recombinant enzyme models, mice splenic lymphocytes, and human lymphocytes were used. Bicyclol (1-5 μM) significantly inhibited the proliferation of mice splenic lymphocytes stimulated by concanavalin A (conA). However, bicyclol did not show inhibitory effects on proliferation of human peripheral blood mononuclear cells (hPBMC) induced by phytohemagglutinin (PHA). IMPDH II enzyme kinetic model showed that bicyclol only had a slight regulatory effect on IMPDH II enzyme activity. These results revealed that bicyclol may be not a conventional inhibitor of IMPDH II. Further studies showed that bicyclol could promote recruitment of IMPDH II by active toll-like 2 receptor (TLR2) complex. Such effects lead to the reduction of nuclear factor κB (NF-κB) expression, increase in I-κB expression, and decrease in cytokine release, including tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β). It may be a new mechanism of bicyclol for its anti-inflammatory effect.
Published: 2016

33. Motion analysis and trajectory planning of solar tracking of a class of Space Solar Power Station

Author: Qi-Bao Jin, Jian-yu Fan, and Jin Huang
Subjects: Renewable Energy, Sustainability and the Environment, Ground, business.industry, Computer science, Space-based solar power, Concentrator, Solar energy, Solar tracker, Geostationary orbit, General Materials Science, Electric power, Aerospace engineering, business, Solar power, Remote sensing
Abstract: Space Solar Power Station (SSPS) is a kind of space electrical power system which converts space solar energy into electrical power and transmits it to Earth ground receiving station, the energy from which is a kind of clean and renewable resource. Compared to others, the SSPS with concentrator represents the developing direction of SPSS in the future, among which, Integrated Symmetrical Concentrated system (ISC) proposed by NASA has the advantage of high collecting sunlight efficiency. However, the addition of concentrator system results in complicated mechanism and is more difficult to control in motion than before; therefore, it is particularly important to plan the effective and realizable motion trajectory when travels on its orbit in the space. For the purpose, a method of trajectory planning for this kind of system is proposed in this paper to make concentrator to realize real-time solar tracking by means of the cooperative rotation of transverse truss and concentrator on the Geostationary Orbit (GEO), and the simulation demonstrates its validation and feasibility. Finally, two improved measures especially solution 2 are presented to mitigate the overheating as the result of nonuniformity of the flux distribution on PV array caused by rotation of concentrator.
Published: 2015

34. Corrigendum to 'GJ-4 alleviates Aβ25-35-induced memory dysfunction in mice through protecting the neurovascular unit' [Biomed. Pharmacother. 127 (2020) 110131]

Author: Fangyuan Li, Xin-Sheng Yao, Zhe Zhao, Lu Wang, Dan Zhang, Yang Yu, Xiu-Qi Bao, Hanyu Yang, Caixia Zang, Zihong Zhang, Hui Liu, and Cheng Ju
Subjects: Pharmacology, Memory Dysfunction, business.industry, Anesthesia, Medicine, Therapeutics. Pharmacology, RM1-950, General Medicine, Neurovascular bundle, business
Published: 2020

35. Benign esophageal schwannoma

Author: Weizhen Shou, Chunxiao Wu, Ze-Quan Zhang, Qiquan Yu, Kun Zhang, and Qi Bao
Subjects: Benign Esophageal Schwannoma, medicine.medical_specialty, biology, business.industry, CD117, CD34, Histology, General Medicine, Schwannoma, medicine.disease, Dysphagia, Lesion, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, otorhinolaryngologic diseases, biology.protein, Medicine, 030212 general & internal medicine, Radiology, Esophagus, medicine.symptom, business
Abstract: Rationale Schwannoma is a tumor of the peripheral nervous system that originated in the Schwann cells of the neural sheath. Esophageal schwannomas are rare esophageal submucosal tumors, comprising approximately 2% of esophageal tumors. Since the symptoms, signs, and images of esophageal schwannoma are not specific, its preoperative diagnosis remains challenging. Patient concerns A 67-year-old woman visited our department with complaints of gradually developed dysphagia and dyspnea for 4 years. A chest computed tomography scan showed a well-demarcated, enhancing homogeneous tumor measuring 61 × 46 × 60 mm in the upper third of the esophagus. Upper gastrointestinal endoscopy revealed a smooth elevated lesion located 19 to 24 cm from the incisor teeth. An endoscopic ultrasound-guided fine-needle aspiration demonstrated the presence of benign spindle cells. Diagnoses Histopathologic examination revealed spindle-shaped cells in a fasciculated and disarrayed architecture. The immunohistochemical study showed positivity for S-100 protein antibody and absence of staining for CD117, CD34, smooth muscle actin, and Desmin. These findings confirmed the diagnosis of benign esophageal schwannoma. Interventions The tumor was considered to be difficult to repair the esophagus by direct anastomosis after tumor resection. Therefore, subtotal esophagectomy and esophagogastrostomy in the right thorax were performed. Outcomes The patient has been doing well with no recurrence at 36 months after the operation. Lessons The symptoms and surgical procedures for benign esophageal schwannoma depend on the size and location of the tumor, proper and timely treatment is essential. A definitive diagnosis is confirmed by histology, and complete excision should yield good results.
Published: 2020

36. Design of Stereo LED Plant Light Source System with High Spatial Illumination Uniformity

Author: 文尚胜 Wen Shang-sheng, 卢允乐 Lu Yun-le, 黄玮钊 Huang Weizhao, 马丙戌 Ma Bing-xu, 吴启保 Wu Qi-bao, 焦飞宇 Jiao Feiyu, 张博 Zhang Bo, and 姜昕宇 Jiang Xin-yu
Subjects: Optics, Light source, business.industry, Environmental science, business, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Published: 2020

37. Determination of acyclovir in renal microdialysis fluid and confirmation of renal function index

Author: Hong Lu, Zhe-Lun Shen, QingQing Yu, Yi-Qi Bao, and Yang-Lei Li
Subjects: Microdialysis, viruses, Health, Toxicology and Mutagenesis, Renal function, Acyclovir, 010501 environmental sciences, Pharmacology, Toxicology, Kidney, 01 natural sciences, Antiviral Agents, Models, Biological, Drug Administration Schedule, Nephrotoxicity, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, In vivo, Medicine, Distribution (pharmacology), Toxicokinetics, Animals, skin and connective tissue diseases, Chromatography, High Pressure Liquid, 0105 earth and related environmental sciences, Chemical Health and Safety, business.industry, Public Health, Environmental and Occupational Health, virus diseases, General Medicine, medicine.anatomical_structure, Toxicity, Injections, Intravenous, Kidney Diseases, business, 030217 neurology & neurosurgery
Abstract: Acyclovir (ACV) is a nucleoside antivirus-free agent that was developed and marketed by Burroughs Well-come of the United States. Renal damage from ACV has been a major factor limiting its clinical application. Thus, the renal toxicity mechanism of ACV requires systematic study. In our previous study, we speculated that the nephrotoxicity of ACV may be associated with oxidative stress. In addition to the study of ACV's toxic effect in vivo, it is also necessary to explore the absorption and distribution of ACV in the body to further investigate the changes to ACV in the body. In this study, the toxicokinetics ACV in the kidney of the rat were explored using microdialysis, and the renal function of rats was measured. The results showed that high-dose ACV is associated with renal toxicity after a single intravenous injection or successive administration.
Published: 2018

38. Evidence and potential mechanisms of traditional Chinese medicine for the treatment of type 2 diabetes: A systematic review and meta-analysis

Author: Qiyou Ding, Jiaxing Tian, Qi Bao, Xiaolin Tong, Fengmei Lian, Zezheng Gao, Haiyu Zhang, Juexian Song, and De Jin
Subjects: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Traditional Chinese medicine, 030204 cardiovascular system & hematology, law.invention, Diabetes Complications, Prediabetic State, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Randomized controlled trial, Diabetes management, law, Diabetes mellitus, Internal Medicine, Medicine, Humans, Intervention Duration, Prediabetes, Medicine, Chinese Traditional, Intensive care medicine, Randomized Controlled Trials as Topic, business.industry, medicine.disease, Treatment Outcome, Diabetes Mellitus, Type 2, Meta-analysis, Female, business, Drugs, Chinese Herbal, Phytotherapy
Abstract: Traditional Chinese medicine (TCM) has recorded knowledge of diabetes for over 2000 years. Because a considerable number of TCM studies exhibit design defects, such as limited intervention duration, small sample sizes and inconsistent efficacy evaluations, the role of TCM in the treatment of diabetes cannot be fully elucidated. In this review, we evaluate randomized controlled trials of prediabetes, diabetes and diabetic complications published in the past decade. We found that TCM could significantly improve glucose control and clinical indices in patients with diabetes and effectively delay the progression of diabetes. We also summarize potential pharmacological mechanisms underlying the efficacy of TCM medication/herbs and their active ingredients for treating diabetes. More rigorously designed experiments and long-term evaluation of TCM for diabetes will allow for more effective diabetes management.
Published: 2018

39. MicroRNA-26a reduces synovial inflammation and cartilage injury in osteoarthritis of knee joints through impairing the NF-κB signaling pathway

Author: Xiusong Dai, Zhi Zhao, Zhi-Yan Wang, Jianzhong Guan, and Zheng-Qi Bao
Subjects: 0301 basic medicine, Male, Pathology, medicine.medical_specialty, Anterior cruciate ligament, Biophysics, Inflammation, Osteoarthritis, Biochemistry, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Medicine, Animals, Inflammatory injury, NF-κB signaling pathway, Molecular Biology, Research Articles, TUNEL assay, Synovial inflammation, business.industry, Cartilage, Synovial Membrane, NF-kappa B, MicroRNA-26a, Cell Biology, Hyperplasia, Osteoarthritis, Knee, medicine.disease, Cartilage injury, Synoviocytes, Rats, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, Apoptosis, 030220 oncology & carcinogenesis, Female, medicine.symptom, Signal transduction, business, Research Article, Signal Transduction
Abstract: Objective: Inflammation is closely implicated in the process of osteoarthritis (OA) and affects disease progression and pain. Herein, the present study explored the effect of microRNA-26a (miR-26a) on the synovial inflammation and cartilage injury in OA, with the involvement with the NF-κB signaling pathway. Methods: Rat models of OA were established by anterior cruciate ligament transection, which were then treated with miR-26a mimics/inhibitors or BMS-345541 (inhibitor of NF-κB pathway). The expression of miR-26a and activator proteins of NF-κB pathway (P-IκBα and P-P65) in synovial tissues was determined. Hematoxylin-eosin (HE) staining was adopted to observe pathological changes of knee joints, synovial tissues, and cartilage of femoral condyle. Terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining was used to detect the apoptosis of synoviocytes and chondrocytes. Results: Poorly expressed miR-26a and increased protein levels of P-IκBα and P-P65 were identified in synovial tissues of OA rats. Besides, OA rats showed obvious synovial tissue hyperplasia, inflammation and cartilage injury of femoral condyle, as well as increased inflammation and cartilage injury scores, and apoptosis of synoviocytes and chondrocytes. In response to miR-26a mimics, protein levels of P-IκBα and P-P65 were reduced; meanwhile, synovial tissue hyperplasia, inflammation and cartilage injury of femoral condyle were ameliorated, with decreased inflammation and cartilage injury scores, and apoptosis of synoviocytes and chondrocytes. Conclusion: MiR-26a suppressed the activation of the NF-κB signaling pathway, by which mechanism the synovial inflammation and cartilage injury in OA rats were alleviated.
Published: 2018

40. Does Adjuvant Treatment with Chinese Herbal Medicine to Antidiabetic Agents Have Additional Benefits in Patients with Type 2 Diabetes? A System Review and Meta-Analysis of Randomized Controlled Trials

Author: Fengmei Lian, Jiaxing Tian, De Jin, Haiyu Zhang, Qiyou Ding, Tong Xiao-lin, and Qi Bao
Subjects: medicine.medical_specialty, business.industry, medicine.medical_treatment, MEDLINE, 030209 endocrinology & metabolism, lcsh:Other systems of medicine, Type 2 diabetes, Review Article, Cochrane Library, lcsh:RZ201-999, Placebo, medicine.disease, law.invention, 03 medical and health sciences, 0302 clinical medicine, Complementary and alternative medicine, Randomized controlled trial, law, Internal medicine, Meta-analysis, Medicine, 030212 general & internal medicine, business, Adverse effect, Adjuvant
Abstract: Introduction. In the present meta-analysis, we aimed to determine the effects of adjuvant treatment with Chinese herbal medicine (CHM) on antidiabetic agents having additional benefits in patients with type 2 diabetes. Methods. Randomized controlled trials were identified by searching the Cochrane Library, PUBMED, EMBASE, MEDLINE, the China National Knowledge Internet, Web of Science, Global Health, International Pharmaceutical Abstracts and the China biology medicine, Wanfang, and VIP databases. The intervention group received CHM as add-on treatment to antidiabetic agents therapy, and the control group received placebos in addition to antidiabetic agents or antidiabetic agents alone. We assessed pooled data, including weighted mean differences and 95% confidence intervals (CIs) using a random-effects model. Results. A total of 125 randomized controlled trials were included. 10 articles were included based on literature screening. All trials contrasted Chinese herbal medicines or Chinese herbal medicines + antidiabetic agents with placebo or antidiabetic agents + placebo and included a total of 2004 individuals with T2DM. All selected trials displayed evidence of high methodological quality and possessed a low risk of bias. Meta-analysis of the trials demonstrated that Chinese herbal medicines resulted in a more favorable blood glucose profile in contrast to placebo (P Conclusions. The results showed that in the intervention group, greater reductions were achieved for glucose control and body weight. The combined use of drugs improves the curative effect and has fewer adverse events and has additional benefits in patients with type 2 diabetes. This trial is registered with PROSPERO (CRD42018093867).
Published: 2018

41. Effectiveness of traditional Chinese medicine Jinlida granules as an add-on therapy for type 2 diabetes: A system review and meta-analysis of randomized controlled trials

Author: De Jin, Xiaolin Tong, Fengmei Lian, Yiru Zhao, and Qi Bao
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Randomized controlled trial, law, Diabetes mellitus, Internal medicine, medicine, Humans, Hypoglycemic Agents, Adverse effect, Glycemic, Randomized Controlled Trials as Topic, business.industry, medicine.disease, Prognosis, Diabetes Mellitus, Type 2, Meta-analysis, Homeostatic model assessment, Drug Therapy, Combination, business, Drugs, Chinese Herbal
Abstract: Jinlida granules are a commonly prescribed oral medication in China used in combination with antidiabetic drugs to lower blood glucose. The aim of this study was to systematically identify and pool the findings of randomized controlled trials evaluating the effectiveness and safety of Jinlida granules as add-on therapy for glycemic control in type 2 diabetes (T2D).The China National Knowledge Infrastructure (CNKI), Wang Fang, PubMed, China biology medicine (CBM), and VIP Database for Chinese Technical Periodicals (VIP) databases were searched for papers regarding the effects of Jinlida granules in T2D published before 1 July 2018. A pooled analysis of extracted data was performed using random-effects models.In all, data were retrieved for 15 studies including 1810 individuals. Decreases in HbA1c were greater in groups receiving Jinlida granules as add-on therapy compared with control groups (n = 1820; mean difference - 0.66; 95% confidence interval - 0.72, -0.60; P 0.00001; IFindings from this meta-analysis demonstrate additional benefits of Jinlida granules as an add-on therapy for T2D and that Jinlida granules are generally safe. Treatment with Jinlida granules provided clinically and statistically significant reductions in fasting plasma glucose, 2-hour post-load glucose, and HbA1c levels in patients with T2D. However, the findings should be interpreted with caution due to the small sample size and study limitations.背景: 津力达颗粒是我国常用的口服中成药，常与降糖药联合应用以降低血糖。本研究旨在系统评价津力达颗粒作为叠加疗法联合降糖药物治疗2型糖尿病的有效性和安全性。方法: 检索2018年7月1日前发表的关于津力达颗粒干预2型糖尿病随机对照试验的论文，使用CNKI、 Wangfang、PubMed、CBM、VIP数据库。使用随机效应模型对提取的数据进行meta分析。结果: 检索得到15项研究数据，包括1810名受试者。加用津力达颗粒的治疗组糖化血红蛋白下降明显高于对照组(n=1820；平均差= -0.66；95%置信区间(-0.72，-0.60)；P0.00001；I
Published: 2018

42. The surgical safety checklist and patient outcomes after surgery

Author: T.E.F. Abbott, T. Ahmad, M.K. Phull, A.J. Fowler, R. Hewson, B.M. Biccard, M.S. Chew, M. Gillies, R.M. Pearse, Rupert M. Pearse, Scott Beattie, Pierre-Alain Clavien, Nicolas Demartines, Lee A. Fleisher, Mike Grocott, James Haddow, Andreas Hoeft, Peter Holt, Rui Moreno, Naomi Pritchard, Andrew Rhodes, Duminda Wijeysundera, Matt Wilson, Tahania Ahmed, Kirsty Everingham, Russell Hewson, Marta Januszewska, Mandeep-Kaur Phull, Richard Halliwell, Mark Shulman, Paul Myles, Werner Schmid, Michael Hiesmayr, Patrick Wouters, Stefan de Hert, Suzana Lobo, Xiangming Fang, Lars Rasmussen, Emmanuel Futier, Matthieu Biais, Aurélien Venara, Karem Slim, Michael Sander, Despoina Koulenti, Kostoula Arvaniti, Mathew Chan, Atul Kulkarni, Susilo Chandra, Aida Tantri, Emad Geddoa, Muntadhar Abbas, Giorgio Della Rocca, Datin Sivasakthi, Marzida Mansor, Pastor Luna, Arthur Bouwman, Wolfgang Buhre, Vanessa Beavis, Douglas Campbell, Tim Short, Tunde Osinaike, Ricardo Matos, Ioana Grigoras, Mikhail Kirov, Denis Protsenko, Bruce Biccard, Cesar Aldecoa, Michelle Chew, Christoph Hofer, Martin Hubner, James Ditai, Tamas Szakmany, Lee Fleisher, Marissa Ferguson, Michael MacMahon, Ritchie Cherian, Helen Currow, Kathirgamanathan Kanathiban, David Gillespie, Edward Pathmanathan, Katherine Phillips, Jenifer Reynolds, Joanne Rowley, Jeanene Douglas, Ross Kerridge, Sameer Garg, Michael Bennett, Megha Jain, David Alcock, Nico Terblanche, Rochelle Cotter, Kate Leslie, Marcelle Stewart, Nicolette Zingerle, Antony Clyde, Oliver Hambidge, Adam Rehak, Sharon Cotterell, Wilson Binh Quan Huynh, Timothy McCulloch, Erez Ben-Menachem, Thomas Egan, Jennifer Cope, Paul Fellinger, Markus Haisjackl, Simone Haselberger, Caroline Holaubek, Paul Lichtenegger, Florian Scherz, Franz Hoffer, Veronika Cakova, Andreas Eichwalder, Norbert Fischbach, Reinhold Klug, Elisabeth Schneider, Martin Vesely, Reinhart Wickenhauser, Karl Gernot Grubmueller, Marion Leitgeb, Friedrich Lang, Nancy Toro, Marlene Bauer, Friedrich Laengle, Claudia Haberl, Thomas Mayrhofer, Christoph Trybus, Christian Buerkle, Karin Forstner, Reinhard Germann, Harald Rinoesl, Elke Schindler, Ernst Trampitsch, Gerhard Bogner, Daniel Dankl, Martin Duenser, Gerhard Fritsch, Ilse Gradwohl-Matis, Andreas Hartmann, Thomas Hoelzenbein, Tarkan Jaeger, Franz Landauer, Gregor Lindl, Michael Lux, Johannes Steindl, Ottokar Stundner, Christian Szabo, Jawad Bidgoli, Hans Verdoodt, Patrice Forget, David Kahn, Fernande Lois, Mona Momeni, Caroline Prégardien, Audrey Pospiech, Arnaud Steyaert, Laurent Veevaete, Dirk De Kegel, Karen De Jongh, Luc Foubert, Carine Smitz, Marcel Vercauteren, Jan Poelaert, Veerle Van Mossevelde, Jacques Abeloos, Stefaan Bouchez, Marc Coppens, Luc De Baerdemaeker, Isabel Deblaere, Ann De Bruyne, Kristine Fonck, Bjorn Heyse, Tom Jacobs, Koen Lapage, Anneliese Moerman, Martine Neckebroek, Aliaksandra Parashchanka, Nathalie Roels, Nancy Van Den Eynde, Michael Vandenheuvel, JurgenVan Limmen, Ann Vanluchene, Caroline Vanpeteghem, Piet Wyffels, Christel Huygens, Punitha Vandenbempt, Marc Van de Velde, Dimitri Dylst, Bruno Janssen, Evelien Schreurs, Fábia Berganton Aleixo, Keulle Candido, Hugo Dias Batista, Mario Guimarães, Jaqueline Guizeline, João Hoffmann, Francisco Ricardo Marques Lobo, Vinícius Nascimento, Katia Nishiyama, Lucas Pazetto, Daniela Souza, Rodrigo Souza Rodrigues, Ana Maria Vilela dos Santos, Jaquelline Jardim, Luiz Marcelo Sá Malbouisson, Joao Silva, Paulo do Nascimento Junior, Thalissa Hermínia Baio, Gabriel Isaac Pereira de Castro, Henri Roger Watanabe Oliveira, Cristina Prata Amendola, Gutemberg Cardoso, Daniela Ortega, Ana Flavia Brotto, Mirella Cristine De Oliveira, Álvaro Réa-Neto, Fernando Dias, Maria Eduarda Travi, Luiza Zerman, Pedro Azambuja, Marcos Freitas Knibel, Antonio Martins, William Almeida, Calim Neder Neto, Maria Angela Tardelli, Eliana Caser, Marcio Machado, Crisitiano Aguzzoli, Sérgio Baldisserotto, Fernanda Beck Tabajara, Fernanda Bettega, La Hore Correa Rodrigues Júnior, Julia de Gasperi, Lais Faina, Marcos Farias Nolasco, Bruna Ferreira da Costa Fischer, Mariana Fosch de Campos Ferreira, Cristina Hartmann, Marta Kliemann, Gustavo Luis Hubert Ribeiro, Julia Merladete Fraga, Thiago Motta Netto, Laura Valduga Pozza, Paulo Rafael Wendling, Caroline Azevedo, Juliana Garcia, Marcel Lopes, Bernardo Maia, Paula Maselli, Ralph Melo, Weslley Mendes, Matheus Neves, Jacqueline Ney, Claudio Piras, Christopher Applewhaite, Adrienne Carr, Lorraine Chow, Kaylene Duttchen, Julena Foglia, Michael Greene, Ashley Hinther, Kendra Houston, Thomas Jared McCormick, Jennifer Mikhayel, Sam Montasser, Alex Ragan, Andrew Suen, Adrianna Woolsey, Hai Chuan Yu, Duane Funk, Stephen Kowalski, Regina Legaspi, Heather McDonald, Faisal Siddiqui, Jeremy Pridham, Bernadette Rowe, Sonia Sampson, Barton Thiessen, Geoff Zbitnew, Andre Bernard, Ronald George, Philip Jones, Rita Moor, Naveed Siddiqui, Alexandra Wolfer, Diem Tran, Denyse Winch, Gary Dobson, Thomas McCormick, Osama Montasser, Richard Hall, Leyla Baghirzada, Gerard Curley, Si Yuan Dai, Gregory Hare, Esther Lee, Uma Shastri, Albert Tsui, Anmol Yagnik, Danielle Alvares, Stephen Choi, Heather Dwyer, Kathrina Flores, Colin McCartney, Priya Somascanthan, Jo Carroll, Janneth Pazmino-Canizares, Noam Ami, Vincent Chan, Anahi Perlas, Ruth Argue, Yang Huang, Katie Lavis, Kelly Mayson, Ying Cao, Hong Gao, Tingju Hu, Jie Lv, Jian Yang, Yang Yang, Yi Zhong, Jing Zhou, Xiaohua Zou, Miao He, Xiaoying Li, Dihuan Luo, Haiying Wang, Tian Yu, Liyong Chen, Lijun Wang, Yunfei Cai, Zhongming Cao, Yanling Li, Jiaxin Lian, Haiyun Sun, Sheng Wang, Zhipeng Wang, Kenru Wang, Yi Zhu, Xindan Du, Hao Fan, Yunbin Fu, Lixia Huang, Yanming Huang, Haifang Hwan, Hong Luo, Pi-Sheng Qu, Fan Tao, Zhen Wang, Guoxiang Wang, Shun Wang, Yan Zhang, Xiaolin Zhang, Chao Chen, Weixing Wang, Zhengyuan Liu, Lihua Fan, Jing Tang, Yijun Chen, Yongjie Chen, Yangyang Han, Changshun Huang, Guojin Liang, Jing Shen, Jun Wang, Qiuhong Yang, Jungang Zhen, Haidong Zhou, Junping Chen, Zhang Chen, Xiaoyu Li, Bo Meng, Haiwang Ye, Xiaoyan Zhang, Yanbing Bi, Jianqiao Cao, Fengying Guo, Hong Lin, Yang Liu, Meng Lv, Pengcai Shi, Xiumei Song, Chuanyu Sun, Yongtao Sun, Yuelan Wang, Shenhui Wang, Min Zhang, Rong Chen, Jiabao Hou, Yan Leng, Qing-tao Meng, Li Qian, Zi-ying Shen, Zhong-yuan Xia, Rui Xue, Yuan Zhang, Bo Zhao, Xian-jin Zhou, Qiang Chen, Huinan Guo, Yongqing Guo, Yuehong Qi, Zhi Wang, Jianfeng Wei, Weiwei Zhang, Lina Zheng, Qi Bao, Yaqiu Chen, Yijiao Chen, Yue Fei, Nianqiang Hu, Xuming Hu, Min Lei, Xiaoqin Li, Xiaocui Lv, Fangfang Miao, Lingling Ouyang, Lu Qian, Conyu Shen, Yu Sun, Yuting Wang, Dong Wang, Chao Wu, Liyuan Xu, Jiaqi Yuan, Lina Zhang, Huan Zhang, Yapping Zhang, Jinning Zhao, Chong Zhao, Lei Zhao, Tianzhao Zheng, Dachun Zhou, Haiyan Zhou, Ce Zhou, Kaizhi Lu, Ting Zhao, Changlin He, Hong Chen, Shasha Chen, Baoli Cheng, Jie He, Lin Jin, Caixia Li, Hui Li, Yuanming Pan, Yugang Shi, Xiao Hong Wen, Shuijing Wu, Guohao Xie, Kai Zhang, Bing Zhao, Xianfu Lu, Feifei Chen, Qisheng Liang, Xuewu Lin, Yunzhi Ling, Gang Liu, Jing Tao, Lu Yang, Jialong Zhou, Fumei Chen, Zhonggui Cheng, Hanying Dai, Yunlin Feng, Benchao Hou, Haixia Gong, Chun hua Hu, Haijin Huang, Jian Huang, Zhangjie Jiang, Mengyuan Li, Jiamei Lin, Mei Liu, Weicheng Liu, Zhen Liu, Zhiyi Liu, Foquan Luo, Longxian Ma, Jia Min, Xiaoyun Shi, Zhiping Song, Xianwen Wan, Yingfen Xiong, Lin Xu, Shuangjia Yang, Qin Zhang, Hongyan Zhang, Huaigen Zhang, Xuekang Zhang, Lili Zhao, Weihong Zhao, Weilu Zhao, Xiaoping Zhu, Yun Bai, Linbi Chen, Sijia Chen, Qinxue Dai, Wujun Geng, Kunyuan Han, Xin He, Luping Huang, Binbin Ji, Danyun Jia, Shenhui Jin, Qianjun Li, Dongdong Liang, Shan Luo, Lulu Lwang, Yunchang Mo, Yuanyuan Pan, Xinyu Qi, Meizi Qian, Jinling Qin, Yelong Ren, Yiyi Shi, Junlu Wang, Junkai Wang, Leilei Wang, Junjie Xie, Yixiu Yan, Yurui Yao, Mingxiao Zhang, Jiashi Zhao, Xiuxiu Zhuang, Yanqiu Ai, Fang Du, Long He, Ledan Huang, Zhisong Li, Huijuan Li, Yetong Li, Liwei Li, Su Meng, Yazhuo Yuan, Enman Zhang, Jie Zhang, Shuna Zhao, Zhenrong Ji, Ling Pei, Li Wang, Chen Chen, Beibei Dong, Jing Li, Ziqiang Miao, Hongying Mu, Chao Qin, Lin Su, Zhiting Wen, Keliang Xie, Yonghao Yu, Fang Yuan, Xianwen Hu, Ye Zhang, Wangpin Xiao, Zhipeng Zhu, Qingqing Dai, Kaiwen Fu, Rong Hu, Xiaolan Hu, Song Huang, Yaqi Li, Yingping Liang, Shuchun Yu, Zheng Guo, Yan Jing, Na Tang, Jie Wu, Dajiang Yuan, Ruilin Zhang, Xiaoying Zhao, Yuhong Li, Hui-Ping Bai, Chun-Xiao Liu, Fei-Fei Liu, Wei Ren, Xiu-Li Wang, Guan-Jie Xu, Na Hu, Bo Li, Yangwen Ou, Yongzhong Tang, Shanglong Yao, Shihai Zhang, Cui-Cui Kong, Bei Liu, Tianlong Wang, Wei Xiao, Bo Lu, Yanfei Xia, Jiali Zhou, Fang Cai, Pushan Chen, Shuangfei Hu, Hongfa Wang, Qiong Xu, Liu Hu, Liang Jing, Bin Li, Qiang Liu, Yuejiang Liu, Xinjian Lu, Zhen Dan Peng, Xiaodong Qiu, Quan Ren, Youliang Tong, Jin Wang, Yazhou Wen, Qiong Wu, Jiangyan Xia, Jue Xie, Xiapei Xiong, Shixia Xu, Tianqin Yang, Hui Ye, Ning Yin, Jing Yuan, Qiuting Zeng, Baoling Zhang, Kang Zheng, Jing Cang, Shiyu Chen, Yu Fan, Shuying Fu, Xiaodong Ge, Baolei Guo, Wenhui Huang, Linghui Jiang, Xinmei Jiang, Yi Liu, Yan Pan, Yun Ren, Qi Shan, Jiaxing Wang, Fei Wang, Chi Wu, Xiaoguang Zhang, Ida Cecilie Christiansen, Simon Nørgaard Granum, Bodil Steen Rasmussen, Morten Daugaard, Rajiv Gambhir, Birgitte Brandsborg, Guðný Erla Steingrímsdóttir, Peter Jensen-Gadegaard, Karsten Skovgaard Olsen, Hanna Siegel, Katrine Zwicky Eskildsen, Mona Ring Gätke, Ida Wibrandt, Simon Bisgaard Heintzelmann, Kai Henrik Wiborg Lange, Rune Sarauw Lundsgaard, Louise Amstrup-Hansen, Claus Hovendal, Michael Larsen, Mette Lenstrup, Tina Kobborg, Jens Rolighed Larsen, Anette Barbre Pedersen, Søren Hübertz Smith, Rebecca Monett Oestervig, Arash Afshari, Cheme Andersen, Kim Ekelund, Erik Lilja Secher, Helene Beloeil, Sigismond Lasocki, Alexandre Ouattara, Marlene Sineus, Serge Molliex, Marie Lim Legouge, Florent Wallet, Antoine Tesniere, Christophe Gaudin, Paul Lehur, Emma Forsans, Stéphane de Rudnicki, Valerie Serra Maudet, Didier Mutter, Ghassan Sojod, Mehdi Ouaissi, Jean-Marc Regimbeau, Jacques Desbordes, Nicolas Comptaer, Diae el Manser, Sabine Ethgen, Gilles Lebuffe, Patrick Auer, Christine Härtl, Maria Deja, Kirill Legashov, Susanne Sonnemann, Carola Wiegand-Loehnert, Elke Falk, Marit Habicher, Stefan Angermair, Beatrix Laetsch, Katrin Schmidt, Christian Von Heymann, Axel Ramminger, Florian Jelschen, Svenja Pabel, Andreas Weyland, Elke Czeslick, Jochen Gille, Michael Malcharek, Armin Sablotzki, Katharina Lueke, Peter Wetzel, Joerg Weimann, Franz-Peter Lenhart, Florian Reichle, Frederike Schirmer, Michael Hüppe, Karl Klotz, Carla Nau, Julika Schön, Thomas Mencke, Christina Wasmund, Carla Bankewitz, Georg Baumgarten, Andreas Fleischer, Vera Guttenthaler, Yvonne Hack, Katharina Kirchgaessner, Olja Männer, Marlen Schurig-Urbaniak, Rafael Struck, Rebekka van Zyl, Maria Wittmann, Ulrich Goebel, Sarah Harris, Siegfried Veit, Evangelia Andreadaki, Flora Souri, Ioannis Katsiadramis, Anthi Skoufi, Maria Vasileiou, Eleni Aimoniotou- Georgiou, Anastasios Katsourakis, Fotini Veroniki, Glyceria Vlachogianni, Konstantina Petra, Dimitra Chlorou, 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Sanjay Shah, Praburaj Ar, Radhakrishnan Muthuchellappan, Vandana Agarwal, Jigeeshu Divatia, Sanghamitra Mishra, Ganesh Nimje, Swati Pande, Sukhada Savarkar, Aditi Shrivastava, Martin Thomas, Shashikant Yegnaram, Rahmat Hidayatullah, Nasman Puar, Sumara Niman, Imai Indra, Zulkarnain Hamzah, Annika Yuliana, Ucu Nurhadiat Abidin, Ade Nurkacan Dursin, Andri Kurnia, Ade Susanti, Dini Handayani, Mahaalit Aribawa Alit, Aryabiantara Arya, Tjokorda Gde Agung Senapathi, Utara Hartawan Utara, Widnyana Made Wid, Semarawima Wima, Wiryana Made Wir, Brillyan Jehosua, Jonathan Kaunang, Eka Yudha Lantang, Rini Najoan, Neil Waworuntu, Hadi Awad, Akram Fuad, Burair Geddoa, Abdel Razzaq Khalaf, Sabah Al hussaini, Safauldeensalem Albaj, Maithem Kenber, Alessandra Bettinelli, Savino Spadaro, Carlo AlbertoVolta, Luigi Giancarlo, Vicari Sottosanti, Elisa Copetti, Lorenzo Spagnesi, Ilaria Toretti, Chiara Alloj, Silvano Cardellino, Livio Carmino, Eleonora Costanzo, Lucia Caterina Fanfani, Maria Teresa Novelli, 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Nahum, Teresa Rotunno, Boris Schiltz, François Voruz, Marc Worreth, Dimitri Christoforidis, Sotirios Georgios Popeskou, Markus Furrer, Gian Andrea Prevost, Andrea Stocker, Klaus Lang, Stefan Breitenstein, Michael T. Ganter, Martin Geisen, Christopher Soll, Michelle Korkmaz, Iris Lubach, Michael Schmitz, Moritz Meyer zu Schwabedissen, Meyer zu Schwabedissen Moritz, Urs Zingg, Thomas Hillermann, Stefan Wildi, Bernardo Bollen Pinto, Bernhard Walder, Giustina Mariotti, Ksenija Slankamenac, Mirioce Namuyuga, Edward Kyomugisha, Olivia Kituuka, Anne Wesonga Shikanda, Nasser Kakembo, Charles Otim Tom, Webombesa Antonina, Emmanuel Bua, Eden Michael Ssettabi, Joseph Epodoi, Fiona Kabagenyi, Fred Kirya, Ged Dempsey, Colette Seasman, Raja Basit Nawaz Khan, Claire Kurasz, Mark Macgregor, Burhan Shawki, Daren Francis, Vimal Hariharan, Simon Chau, Kate Ellis, Georgina Butt, Dennis-Wayne Chicken, Natasha Christmas, Samantha Allen, Gayatri Daniel Daniel, Angie Dempster, Juliette Kemp, Lewis Matthews, Philip Mcglone, Joanne Tambellini, Dawn Trodd, Katie Freitas, Atul Garg, Janesh Kumar Gupta, Shilpaja Karpate, Aditi Kulkarni, Chloe O'Hara, Jtroko Troko, Kirsty Angus, Jacqueline Bradley, Emma Brennan, Carolyn Brooks, Janette Brown, Gemma Brown, Amanda Finch, Karen Gratrix, Sue Hesketh, Gillian Hill, Carol Jeffs, Maureen Morgan, Chris Pemberton, Nicola Slawson, Helen Spickett, Gemma Swarbrick, Megan Thomas, Greta Van Duyvenvoorde, Andrew Brennan, Richard Briscoe, Sarah Cooper, Tom Lawton, Martin Northey, Rashmi Senaratne, Helen Stanworth, Lorna Burrows, Helen Cain, Rachael Craven, Keith Davies, Attila Jonas, Marcin Pachucki, Graham Walkden, Helen Davies, Mariethel Gudaca, Maria Hobrok, Dilshan Arawwawala, Lauren Fergey, Matthew Gardiner, Jacqueline Gunn, Lyndsay Johnson, Amanda Lofting, Amanda Lyle, Fiona Mc Neela, Susan Smolen, Joanne Topliffe, Sarah Williams, Martin Bland, Packianathaswamy Balaji, Vikas Kaura, Prasad Lanka, Neil Smith, Ahmed Ahmed, John Myatt, Ravikiran Shenoy, Wai Cheong Soon, Jessica Tan, Sunny Karadia, James Self, Emma Durant, Shiva Tripathi, Clare Bullock, Debbie Campbell, Alison Ghosh, Thomas Hughes, Lajos Zsisku, Sheshagiri Bengeri, Amanda Cowton, Mohammed Shazad Khalid, James Limb, Colin McAdam, Mandy Porritt, M. Amir Rafi, Priya Shekar, David Adams, Catherine Harden, Heidi Hollands, Angela King, Linda March, Gary Minto, Abigail Patrick, Rosalyn Squire, Darren Waugh, Paramesh Kumara, Karen Simeson, Jamie Yarwood, Julie Browning, Jonathan Hatton, Howes Julian, Atideb Mitra, Maria Newton, Pawan Kootelu Pernu, Alison Wilson, Thelma Commey, Helen Foot, Lyn Glover, Ajay Gupta, Nicola Lancaster, Jill Levin, Felicity Mackenzie, Claire Mestanza, Emma Nofal, Lauren Pout, Rosanna Varden, Jonathan Wild, Stephanie Jones, Sarah Moreton, Mark Pulletz, Charlotte Davies, Matthew Martin, Sian Thomas, Karen Burns, Carol McArthur, Panna Patel, Gary Lau, Natalie Rich, Fiona Davis, Rachel Lyons, Beth Port, Rachel Prout, Christopher Smith, Yemi Adelaja, Victoria Bennett, Heena Bidd, Alexandra Dumitrescu, Jacqui Fox Murphy, Abigail Keen, Nhlanhla Mguni, Cheng Ong, George Adams, Piers Boshier, Richard Brown, Izabella Butryn, Jayanta Chatterjee, Alexander Freethy, Geoffrey Lockwood, Maria Tsakok, Sophia Tsiligiannis, William Peat, Lorraine Stephenson, Mike Bradburn, Sara Pick, Pedro Cunha, Olufemi Olagbaiye, Salim Tayeh, Balaji Packianathaswamy, Caroline Abernethy, Madhu Balasubramaniam, Rachael Bennett, David Bolton, Victoria Martinson, Charde Naylor, Stephanie Bell, Blaylock Heather, Vlad Kushakovsky, Liam Alcock, Hazel Alexander, Colette Anderson, Paul Baker, Morag Brookes, Louise Cawthorn, Emanuel Cirstea, Rachel Clarkson, Kerry Colling, Ian Coulter, Suparna Das, Kathryn Haigh, Alhafidz Hamdan, Keith Hugill, Lucksy Kottam, Emily Lisseter, Matthew Mawdsley, Julie McGivern, Krishnaveni Padala, Victoria Phelps, Vineshykaa Ramesh kumar, Kirsten Stewart, Kayley Towse, Julie Tregonning, Ali Vahedi, Alycon Walker, Duncan Baines, Anjali Bilolikar, Shiv Chande, Edward Copley, Nigel Dunk, Raghavendra Kulkarni, Pawan Kumar, Yavor Metodiev, Dumisani Ncomanzi, Bhavesh Raithatha, Parizade Raymode, Jan Szafranski, Linda Twohey, Philip Watt, Lucie Weatherall, J. 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Craw N, Craw S, Pitt-Kerby T, Rowland-Axe R, Spurdle K, McDonald A, Simon D, Sinha V, Smith T, Banner-Goodspeed V, Boone M, Campbell K, Lu F, Scannell J, Sobol J, Balajonda N, Clemmons K, Conde C, Elgasim M, Funk B, Hall R, Hopkins T, Olaleye O, Omer O, Pender M, Porto A, Stevens A, Waweru P, Yeh E, Bodansky D, Evans A, Kleopoulos S, Maril R, Mathney E, Sanchez A, Tinuoye E, Bateman B, Eng K, Jiang N, Ladha K, Needleman J, Chen LL, Lane R, Robinowitz D, Ghushe N, Irshad M, O'Connor J, Patel S, Takemoto S, Wallace A, Mazzeffi M, Rock P, Wallace K, Zhu X, Chua P, Mattera M, Sharar R, Thilen S, Treggiari M, Morgan A, Sofjan I, Subramaniam K, Avidan M, Maybrier H, Muench M, Wildes T., Université de Lille, CHU Lille, Queen Mary University of London [QMUL], Graduate School, Medical Microbiology and Infection Prevention, Clinical Immunology and Rheumatology, 01 Internal and external specialisms, ACS - Heart failure & arrhythmias, AGEM - Endocrinology, metabolism and nutrition, APH - Quality of Care, ACS - Diabetes & metabolism, AII - Amsterdam institute for Infection and Immunity, ACS - Microcirculation, Pearse, R M, International Surgical Outcomes Study (ISO), Group, Zangrillo, A, Landoni, G, Beretta, L., International Surgical Outcomes Study (ISOS) group, Pearse, R.M., Beattie, S., Clavien, P.A., Demartines, N., Fleisher, L.A., Grocott, M., Haddow, J., Hoeft, A., Holt, P., Moreno, R., Pritchard, N., Rhodes, A., Wijeysundera, D., Wilson, M., Ahmed, T., Everingham, K., Hewson, R., Januszewska, M., Phull, M.K., Halliwell, R., Shulman, M., Myles, P., Schmid, W., Hiesmayr, M., Wouters, P., de Hert, S., Lobo, S., Fang, X., Rasmussen, L., Futier, E., Biais, M., Venara, A., Slim, K., Sander, M., Koulenti, D., Arvaniti, K., Chan, M., Kulkarni, A., Chandra, S., Tantri, A., Geddoa, E., Abbas, M., Della Rocca, G., Sivasakthi, D., Mansor, M., Luna, P., Bouwman, A., Buhre, W., Beavis, V., Campbell, D., Short, T., Osinaike, T., Matos, R., Grigoras, I., Kirov, M., Protsenko, D., 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Stafylaraki, M., Gaitanakis, S., Karydakis, P., Paltoglou, J., Ponireas, P., Chaloulis, P., Provatidis, A., Sousana, A., Gardikou, V.V., Konstantivelli, M., Lataniotou, O., Lisari, E., Margaroni, M., Stamatiou, K., Nikolaidis, E., Pnevmatikos, I., Sertaridou, E., Andreou, A., Arkalaki, E., Athanasakis, E., Chaniotaki, F., Chatzimichali, C.A., Christofaki, M., Dermitzaki, D., Fiorentza, K., Frantzeskos, G., Geromarkaki, E., Kafkalaki, K., Kalogridaki, M., Karydi, K., Kokkini, S., Kougentakis, G., Lefaki, T., Lilitsis, E., Makatounaki, A., Malliotakis, P., Michelakis, D., Neonaki, M., Nyktari, V., Palikyra, I., Papadakis, E., Papaioannou, A., Sfakianakis, K., Sgouraki, M., Souvatzis, X., Spartinou, A., Stefanidou, N., Syrogianni, P., Tsagkaraki, G., Arnaoutoglou, E., Arnaoutoglou, C., Bali, C., Bouris, V., Doumos, R., Gkini, K.P., Kapaktsi, C., Koulouras, V., Lena, A., Lepida, D., Michos, E., Papadopoulos, D., Paschopoulos, M., Rompou, V.A., Siouti, I., Tsampalas, S., Ververidou, O., 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I., Alloj, C., Cardellino, S., Carmino, L., Costanzo, E., Fanfani, L.C., Novelli, M.T., Roasio, A., Bellandi, M., Bignami, E., Bocchino, S., Cabrini, L., Corti, D., Landoni, G., Meroni, R., Moizo, E., Monti, G., Pintaudi, M., Plumari, V.P., Taddeo, D., Testa, V., Winterton, D., Zangrillo, A., Cloro, L.M., Colangelo, C., Colangelo, A., Rotunno, G., Paludi, M.A., Maria, C.P., Pata, A., Parrini, V., Gatta, A., Nastasi, M., Tinti, C., Baroselli, A., Arrigo, M., Benevento, A., Bottini, C., Cannavo', M., Gastaldi, C., Marchesi, A., Pascazio, A., Pata, F., Pozzi, E., Premoli, A., Tessera, G., Boschi, L., D'Andrea, R., Ghignone, F., Poggioli, G., Sibilio, A., Taffurelli, M., Ugolini, G., Ab Majid, M.A., Ab Rahman, R., Joseph, J., Pathan, F., Sybil Shah, M.H., Yap, H.L., Cheah, S., Chin, I.I., Looi, J.K., Tan, S.C., Visvalingam, S., Kwok, F.Y., Lee, C.K., Tan, T.S., Wong, S.M., Abdullah, N.H., Liew, C.F., Luxuman, L., Mohd Zin, N.H., Norddin, M.F., Raja Alias, R.L., Wong, J.Y., Yong, J., Bin 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Vohra, R., Whitehouse, A., Wong, T., Blunt, M., Wong, K., Giles, J., Reed, I., Weller, D., Bell, G., Birch, J., Damant, R., Maiden, J., Mewies, C., Prince, C., Radford, J., Reynolds, T., Balain, B., Banerjee, R., Barnett, A., Burston, B., Edwards, J., Evans, C., Ford, D., Gallacher, P., Hill, S., Jaffray, D., Karlakki, S., Kennedy, J., Kiely, N., Lewthwaite, S., Marquis, C., Ockendon, M., Phillips, S., Pickard, S., Richardson, J., Roach, R., Smith, T., Spencer-Jones, R., Steele, N., Steen, J., Van Liefland, M., White, S., Faulds, M., Harris, M., Nicol, S., Pearson, S.A., Chukkambotla, S., Andrew, A., Attrill, E., Campbell, G., Datson, A., Fouracres, A., Graterol, J., Graves, L., Hong, B., Ishimaru, A., Karthikeyan, A., King, H., Lawson, T., Lee, G., Lyons, S., Hall, A.M., Mathoulin, S., Mcintyre, E., Mclaughlin, D., Mulcahy, K., Paddle, J., Robbins, J., Sung, W., Tayo, A., Trembath, L., Venugopal, S., Wigmore, G., Boereboom, C., Downes, C., Humphries, R., Melbourne, S., Tou, S., Ullah, S., Batchelor, N., Boxall, L., Broomby, R., Deen, T., Hellewell, A., Helliwell, L., Hutchings, M., Hutchins, D., Keenan, S., Mackie, D., Potter, A., Smith, F., Stone, L., Thorpe, K., Wassall, R., Woodgate, A., Baillie, S., Campbell, T., James, S., King, C., Marques de Araujo, D., Martin, D., Morkane, C., Neely, J., Rajendram, R., Burton, M., James, K., Keevil, E., Minik, O., Morgan, J., Musgrave, A., Rajanna, H., Roberts, T., Adamson, M., Jumbe, S., Kendall, J., Muthuswamy, M.B., Cruikshanks, A., Wrench, I., Zeidan, L., Ardern, D., Harris, B., Hellstrom, J., Martin, J., Thomas, R., Varsani, N., Brown, C.W., Docherty, P., Gillies, M., McGregor, E., Usher, H., Craig, J., Ahmad, T., Bodger, P., Creary, T., Fowler, A., Ijuo, E., Jones, T., Kantsedikas, I., Lahiri, S., McLean, A.L., Niebrzegowska, E., Phull, M., Wickboldt, N., Baldwin, J., Doyle, D., Mcmullan, S., Oladapo, M., Owen, T., Williams, A., Gregory, P., Husain, T., Kirk-Bayley, J., Mathers, E., Montague, L., Harper, M., Jack, J., Ridley, C., Avis, J., Cook, T., Dali-Kemmery, L., Kerslake, I., Lambourne, V., Pearson, A., Boyd, C., Callaghan, M., Lawson, C., McCrossan, R., Nesbitt, V., O'connor, L., Sinclair, R., Farid, N., Morgese, C., Bhatia, K., Karmarkar, S., Ahmed, J., Branagan, G., Hutton, M., Swain, A., Brookes, J., Cornell, J., Dolan, R., Hulme, J., Jansen van Vuuren, A., Jowitt, T., Kalashetty, G., Lloyd, F., Patel, K., Sherwood, N., Brown, L., Chandler, B., Deighton, K., Emma, T., Haunch, K., Cheeseman, M., Dent, K., Gray, C., Hood, M., Jones, D., Juj, J., Rao, R., Walker, T., Al Anizi, M., Cheah, C., Cheing, Y., Coutinho, F., Gondo, P., Hadebe, B., Hove, M.O., Khader, A., Krishnachetty, B., Rhodes, K., Sokhi, J., Baker, K.A., Bertram, W., Looseley, A., Mouton, R., Hanna, G., Arnold, G., Arya, S., Balfoussia, D., Baxter, L., Harris, J., Jones, C., Knaggs, A., Markar, S., Perera, A., Scott, A., Shida, A., Sirha, R., Wright, S., Frost, V., Andrews, E., Arrandale, L., Barrett, S., Cifra, E., Cooper, M., Dragnea, D., Elna, C., Maclean, J., Meier, S., Milliken, D., Munns, C., Ratanshi, N., Ramessur, S., Salvana, A., Watson, A., Ali, H., Critchley, R., Endersby, S., Hicks, C., Liddle, A., Pass, M., Ritchie, C., Thomas, C., Too, L., Welsh, S., Gill, T., Johnson, J., Reed, J., Davis, E., Papadopoullos, S., Attwood, C., Biffen, A., Boulton, K., Gray, S., Hay, D., Mills, S., Montgomery, J., Riddell, R., Simpson, J., Bhardwaj, N., Paul, E., Uwubamwen, N., Alexander, M., Arrich, J., Arumugam, S., Blackwood, D., Boggiano, V., Chan, Y.L., Chatterjee, D., Chhabra, A., Christian, R., Costelloe, H., Matthewman, M.C., Dalton, E., Darko, J., Davari, M., Dave, T., Deacon, M., Deepak, S., Edmond, H., Ellis, J., El-Sayed, A., Eneje, P., English, R., Ewe, R., Foers, W., Franklin, J., Gallego, L., Garrett, E., Goldberg, O., Goss, H., Greaves, R., Harris, R., Hennings, C., Jones, E., Kamali, N., Kokkinos, N., Lewis, C., Lignos, L., Malgapo, E.V., Malik, R., Milne, A., Mulligan, J.P., Nicklin, P., Palipane, N., Parsons, T., Piper, R., Prakash, R., Ramesh, B., Rasip, S., Reading, J., Rela, M., Reyes, A., Stephens, R., Rooms, M., Shah, K., Simons, H., Solanki, S., Spowart, E., Stevens, A., Waggett, H., Yassaee, A., Kennedy, A., Scott, S., Somanath, S., Berg, A., Hernandez, M., Nanda, R., Tank, G., Wilson, N., Wilson, D., Al-Soudaine, Y., Baldwin, M., Cornish, J., Davies, Z., Davies, L., Edwards, M., Frewer, N., Gallard, S., Glasbey, J., Harries, R., Hopkins, L., Kim, T., Koompirochana, V., Lawson, S., Lewis, M., Makzal, Z., Scourfield, S., Ahmad, Y., Bates, S., Blackwell, C., Bryant, H., Collins, H., Coulter, S., Cruickshank, R., Daniel, S., Daubeny, T., Golder, K., Hawkins, L., Helen, B., Hinxman, H., Levett, D., Salmon, K., Seaward, L., Skinner, B., Tyrell, B., Wadams, B., Walsgrove, J., Dickson, J., Constantin, K., Karen, M., O'Brien, P., O'Donohoe, L., Payne, H., Sundayi, S., Walker, E., Brooke, J., Cardy, J., Humphreys, S., Kessack, L., Kubitzek, C., Kumar, S., Cotterill, D., Hodzovic, E., Hosdurga, G., Miles, E., Saunders, G., Campbell, M., Chan, P., Jemmett, K., Raj, A., Naik, A., Oshowo, A., Ramamoorthy, R., Shah, N., Sylvan, A., Blyth, K., Burtenshaw, A., Freeman, D., Johnson, E., Lo, P., Martin, T., Plunkett, E., Wollaston, J., Allison, J., Carroll, C., Craw, N., Craw, S., Pitt-Kerby, T., Rowland-Axe, R., Spurdle, K., McDonald, A., Simon, D., Sinha, V., Banner-Goodspeed, V., Boone, M., Campbell, K., Lu, F., Scannell, J., Sobol, J., Balajonda, N., Clemmons, K., Conde, C., Elgasim, M., Funk, B., Hopkins, T., Olaleye, O., Omer, O., Pender, M., Porto, A., Waweru, P., Yeh, E., Bodansky, D., Evans, A., Kleopoulos, S., Maril, R., Mathney, E., Sanchez, A., Tinuoye, E., Bateman, B., Eng, K., Jiang, N., Ladha, K., Needleman, J., Chen, L.L., Lane, R., Robinowitz, D., Ghushe, N., Irshad, M., O'Connor, J., Patel, S., Takemoto, S., Wallace, A., Mazzeffi, M., Rock, P., Wallace, K., Chua, P., Mattera, M., Sharar, R., Thilen, S., Treggiari, M., Morgan, A., Sofjan, I., Subramaniam, K., Avidan, M., Maybrier, H., Muench, M., and Wildes, T.
Subjects: Male, Postoperative Complications/epidemiology, Hospital mortality, [SDV]Life Sciences [q-bio], surgery, Postoperative Complications, 0302 clinical medicine, cohort studies, 030202 anesthesiology, patient safety, 030212 general & internal medicine, Postoperative Period, Medicine(all), Middle Aged, Checklist, 3. Good health, Treatment Outcome, operative/mortality, Elective Surgical Procedures, Surgical Procedures, Operative, Meta-analysis, Cohort, Cohort studies, Female, Elective Surgical Procedure, postoperative care/methods, postoperative care/statistics and numerical data, surgical procedures, Anesthesiology and Pain Medicine, Cohort study, Adult, medicine.medical_specialty, Evidence-based medicine, NO, 03 medical and health sciences, Patient safety, medicine, postoperative care/method, Humans, Elective Surgical Procedures/standards, Aged, Cohort Studies, Evidence-Based Medicine, Hospital Mortality, Patient Safety, Postoperative Complications/mortality, Postoperative Complications/prevention & control, Surgical Procedures, Operative/methods, business.industry, Odds ratio, Surgery, Observational study, business, cohort studie
Abstract: BACKGROUND: The surgical safety checklist is widely used to improve the quality of perioperative care. However, clinicians continue to debate the clinical effectiveness of this tool.METHODS: Prospective analysis of data from the International Surgical Outcomes Study (ISOS), an international observational study of elective in-patient surgery, accompanied by a systematic review and meta-analysis of published literature. The exposure was surgical safety checklist use. The primary outcome was in-hospital mortality and the secondary outcome was postoperative complications. In the ISOS cohort, a multivariable multi-level generalized linear model was used to test associations. To further contextualise these findings, we included the results from the ISOS cohort in a meta-analysis. Results are reported as odds ratios (OR) with 95% confidence intervals.RESULTS: We included 44 814 patients from 497 hospitals in 27 countries in the ISOS analysis. There were 40 245 (89.8%) patients exposed to the checklist, whilst 7508 (16.8%) sustained ≥1 postoperative complications and 207 (0.5%) died before hospital discharge. Checklist exposure was associated with reduced mortality [odds ratio (OR) 0.49 (0.32-0.77); PCONCLUSIONS: Patients exposed to a surgical safety checklist experience better postoperative outcomes, but this could simply reflect wider quality of care in hospitals where checklist use is routine.
Published: 2018

43. Numerical Analysis on the Behavior of Autoclaved Aerated Concrete Block Infilled Wall Subjected to Gas Explosion

Author: Qi Bao, Wen Xuan Xu, Zhan Li, and Jun Yu Fan
Subjects: Engineering, business.industry, Numerical analysis, Constitutive equation, General Medicine, Structural engineering, Brittleness, Gas explosion, Geotechnical engineering, Boundary value problem, Mortar, Autoclaved aerated concrete, business, Block (data storage)
Abstract: As a common threat to the public safety, gas explosion and its damage on structures have drawn more and more attention in the academic fields. In this paper, a series of numerical simulations are conducted to study the behavior of autoclaved aerated concrete block infilled walls under gas explosion loading. Firstly, considering the difference between the blocks and the mortar, a refined numerical model is established, and the constitutive model of Brittle Damage in LS-DYNA is hired to describe the material behaviours of both materials. Based on the laboratory material test data, the parameter of the material model are selected reasonably. Then, massive numerical calculation is carried out and the dynamic response of autoclaved aerated concrete block infilled walls is captured and discussed. At last, the anti-blast ability of block infilled walls is compared with that of clay infilled wall of the same thickness. It is found that the anti-blast ability of block infilled walls is weaker than the clay infilled walls for the difference of material density and boundary conditions.
Published: 2015

44. Application of Bio-Char from Sewage Sludge Pyrolysis

Author: Qi Bao Wang, Feng Min Chang, and Kai Jun Wang
Subjects: Adsorption, Materials science, Waste management, business.industry, Biochar, General Engineering, Sewage sludge treatment, Sewage, Char, business, Effluent, Pyrolysis, Sludge
Abstract: To promote engineering application of municipal sludge pyrolysis technology and reduce economic cost of sludge pyrolysis operation, the paper discussed the feasibility of sludge-based char application in three aspects: sewage adsorbent, fuel and soil improving agent. Conclusion: the sludge-based char on SCOD adsorption time in the 30min reaches saturation, the SCOD removal rate above 30%; the removal rate of sludge-carbon on A/O reactor effluent COD have less effect, but there are certain effect on nitrogen removal; the sludge-based char can be burned at 400°C, release a lot of heat, it can be used as a low-grade fuel; the sludge-based char can promote plants growth, and has a good safety performance, may be used as a good soil improving agent.
Published: 2014

45. Compound Danshen Dripping Pill for Treating Nonproliferative Diabetic Retinopathy: A Meta-Analysis of 13 Randomized Controlled Trials

Author: De Jin, Qi Bao, Fengmei Lian, and Wenjing Huang
Subjects: medicine.medical_specialty, business.industry, Diabetic retinopathy, lcsh:Other systems of medicine, Review Article, medicine.disease, lcsh:RZ201-999, Surgery, law.invention, Quality of evidence, 03 medical and health sciences, Retinal hemorrhages, 0302 clinical medicine, Complementary and alternative medicine, Randomized controlled trial, law, Internal medicine, Meta-analysis, 030221 ophthalmology & optometry, medicine, 030212 general & internal medicine, Danshen dripping pill, business, Methodological quality, Fundus fluorescein angiography
Abstract: Objective. We assess the clinical effect of compound Danshen dripping pill (CDDP) for treating diabetic retinopathy (DR). Methods. Electronic databases were searched from January 2001 to October 2016 to locate randomized controlled trials (RCTs). Efficacy was measured as main outcome and microaneurysms, hemorrhage, exudate, vision, and fundus fluorescein angiography (FFA) were measured as second outcomes. Methodological quality for each study was evaluated, RevMan 5 software was used to assess treatment effects, and GRADE was used to rate quality of evidence. Results. We located 13 RCTs and methodological quality was evaluated as high risk. Statistics indicated CDDP for treating DR was better than controls and DR risk was reduced 64% with CDDP (RR: 0.36, P=0.68); retinal microaneurysms (MD = −4.32NO, P<0.00001); retinal hemorrhages (MD = −0.70PD, P=0.03); exudate improvements (MD = −0.09PD, P=0.79); visual changes (MD = −0.12 letter, P=0.006); FFA (RR: 0.40, P=0.003). About GRADE, quality of evidence was “low.” Conclusion. CDDP may be safe and efficacious for treating or delaying DR and may improve vision or delay vision loss.
Published: 2017

46. A novel approach for image feature description based on dual gradient orientation histogram

Author: Jia-qi Bao and Xing-peng Mao
Subjects: business.industry, Local binary patterns, GLOH, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Histogram matching, 020207 software engineering, Pattern recognition, 02 engineering and technology, Feature description, ComputingMethodologies_PATTERNRECOGNITION, Computer Science::Computer Vision and Pattern Recognition, Histogram, Computer Science::Multimedia, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Computer vision, Affine transformation, Artificial intelligence, Invariant (mathematics), business, Spatial analysis, Mathematics
Abstract: The robust and distinctive local feature description is a critical component of image matching. In this paper, a novel descriptor, DGOH descriptor, is presented based on dual gradient orientation histogram. DGOH is a full rotation invariant descriptor, which takes advantage of spatial information of features by utilizing intensity order based subregion division method, meanwhile adopts the rotation invariant gradient calculation method in descriptor construction process. The discriminability of DGOH descriptor is enhanced by utilizing dominant and secondary gradient orientation histogram to represent the detected affine feature region. Performance evaluation experiments are carried out on the standard Oxford dataset. The experimental results show that the DGOH descriptor outperforms the state-of-the-art descriptors in terms of stability, precision and efficiency.
Published: 2017

47. Chinese herbal medicine TangBi Formula treatment of patients with type 2 diabetic distal symmetric polyneuropathy disease: study protocol for a randomized controlled trial

Author: Wenjing Huang, Meizhen Zhang, Ya-nan Yang, Fengmei Lian, Xiang Meng, De Jin, Qi Bao, Yu-jiao Zheng, Xiaolin Tong, Fan Yang, and Qing Ni
Subjects: Adult, medicine.medical_specialty, Diabetic neuropathy, Diabetic distal symmetric polyneuropathy, 0211 other engineering and technologies, Medicine (miscellaneous), 02 engineering and technology, Traditional Chinese medicine, Placebo, law.invention, 03 medical and health sciences, Study Protocol, 0302 clinical medicine, Clinical trials, Randomized controlled trial, Diabetic Neuropathies, Double-Blind Method, law, Internal medicine, Diabetes mellitus, 021105 building & construction, Outcome Assessment, Health Care, Medicine, Humans, Multicenter Studies as Topic, Pharmacology (medical), 030212 general & internal medicine, Medicine, Chinese Traditional, Adverse effect, Aged, Randomized Controlled Trials as Topic, lcsh:R5-920, business.industry, Therapeutic effect, Middle Aged, medicine.disease, Clinical trial, Treatment, Diabetes Mellitus, Type 2, lcsh:Medicine (General), business, Drugs, Chinese Herbal
Abstract: Background Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirely satisfactory. Preliminary studies indicated that the Chinese herbal TangBi Formula may alleviate signs and symptoms and improve the velocity of nerve conduction in patients with DSPN. This study was designed to determine if Chinese herbal medicine used in combination with conventional treatment is more effective than conventional treatment alone. Methods/design We are conducting a multicenter, placebo-controlled, double-blind, randomized, controlled clinical trial as a means of assessing the therapeutic effects of traditional Chinese medicine (TCM) treatment. A total of 188 patients will be randomized in a 1:1 ratio to a treatment group (TangBi Formula plus mecobalamin) and a control group (placebo plus mecobalamin). The test period lasts 6 months, during which all of the patients will be given standard medical care as recommended by established guidelines. The primary outcome will be development of differences in changes in clinical symptoms and signs in patients and changes in Michigan Diabetic Neuropathy Score (MDNS) between the two groups before and after treatment. The secondary outcome will be changes in nerve conduction velocity and in single clinical signs and symptoms. Safety assessments and adverse events will also be evaluated. Discussion We postulate that patients with DSPN will benefit from therapy that includes TCM. If successful, this work will provide an evidence-based complementary therapeutic approach for treatment of DSPN. Trial registration ClinicalTrials.gov, NCT03010241. Registered on 2 January 2017 Electronic supplementary material The online version of this article (doi:10.1186/s13063-017-2345-1) contains supplementary material, which is available to authorized users.
Published: 2017

48. The Effects of Pre-Operative Enteral Nutrition from Nasal Feeding Tubes on Gastric Outlet Obstruction

Author: Qi-bao Dai, Suyong Lin, Zhihua Chen, Shao-qin Chen, and Jin Hua
Subjects: Male, Parenteral Nutrition, Gastroenterology, Jejunum, 0302 clinical medicine, Postoperative Complications, Medicine, Hospital Costs, Intubation, Gastrointestinal, immune function, Nutrition and Dietetics, Incidence (epidemiology), Incidence, Gastric outlet obstruction, Middle Aged, Prognosis, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Costs and Cost Analysis, 030211 gastroenterology & hepatology, Female, Adult, pre-operative, enteral nutrition, gastric outlet obstruction, gastroscope, medicine.medical_specialty, China, Nutritional Status, Preoperative care, Article, 03 medical and health sciences, Cicatrix, Enteral Nutrition, Stomach Neoplasms, Statistical significance, Internal medicine, Preoperative Care, Humans, Feeding tube, Wound Healing, business.industry, Gastric Outlet Obstruction, Length of Stay, medicine.disease, Surgery, Parenteral nutrition, Feasibility Studies, business, Gastrointestinal function, Food Science
Abstract: We examined gastric outlet obstruction (GOO) patients who received two weeks of strengthening pre-operative enteral nutrition therapy (pre-EN) through a nasal–jejenal feeding tube placed under a gastroscope to evaluate the feasibility and potential benefit of pre-EN compared to parenteral nutrition (PN). In this study, 68 patients confirmed to have GOO with upper-gastrointestinal contrast and who accepted the operation were randomized into an EN group and a PN group. The differences in nutritional status, immune function, post-operative complications, weight of patients, first bowel sound and first flatus time, pull tube time, length of hospital stay (LOH), and cost of hospitalization between pre-operation and post-operation were all recorded. Statistical analyses were performed using the chi square test and t-test; statistical significance was defined as p < 0.05. The success rate of the placement was 91.18% (three out of 31 cases). After pre-EN, the levels of weight, albumin (ALB), prealbumin (PA), and transferrin (TNF) in the EN group were significantly increased by pre-operation day compared to admission day, but were not significantly increased in the PN group; the weights in the EN group were significantly increased compared to the PN group by pre-operation day and day of discharge; total protein (TP), ALB, PA, and TNF of the EN group were significantly increased compared to the PN group on pre-operation and post-operative days one and three. The levels of CD3+, CD4+/CD8+, IgA, and IgM in the EN group were higher than those of the PN group at pre-operation and post-operation; the EN group had a significantly lower incidence of poor wound healing, peritoneal cavity infection, pneumonia, and a shorter first bowel sound time, first flatus time, and post-operation hospital stay than the PN group. Pre-EN through a nasal–jejunum feeding tube and placed under a gastroscope in GOO patients was safe, feasible, and beneficial to the nutrition status, immune function, and gastrointestinal function, and sped up recovery, while not increasing the cost of hospitalization.
Published: 2017
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49. Outpatient surgery of skin and soft tissue lesions: case summary and perspectives on training

Author: Jie Pan, Cheng Zhong, Zheren Shao, Zhiping Tao, Qi Ma, Huanhuan Wang, Peter Nelson, Xueqing Hu, and Qi Bao
Subjects: Seborrheic keratosis, medicine.medical_specialty, business.industry, Outpatient surgery, Soft tissue, General Medicine, Epidermoid cyst, Compound nevus, medicine.disease, Surgery, Hemangioma, medicine.anatomical_structure, Scalp, medicine, Intradermal Nevus, Pharmacology (medical), business
Abstract: Background & Objectives: Summarize experience in skin and soft tissue lesion surgery in an outpatient operation room (OR) of a large University department, as a means to demonstrate the surgeries in the training of plastic surgeons. Methods: 242 skin and soft tissue lesions were retrospectively analyzed according to pathological classifications and treatments. Results: From Oct. 2014 to Aug. 2015, 212 patients with 242 lesions were operated on in our outpatient OR. 76 cases were male and 136 female, with a mean age of 33.5. The youngest patient was 7-years old, while the oldest was 74. The most frequent pathological types were intradermal nevus (33.5%), compound nevus (15.3%), epidermoid cyst (11.2%), seborrheic keratosis (8.3%), and hemangioma (4.5%). The top five operation sites were at face (42.1%), trunk (11.6%), neck (8.7%), scalp (8.3%) and nose (6.6%). The coincidence rate of pre-operation diagnosis and post-operation pathological diagnosis was 93.0%. The complication rate was 1.2%. Conclusions: The plastic surgery department of public general hospital has a large number of patients with skin and soft tissue lesions that belong to a variety of pathological types. This provides a good platform to train plastic surgeons.
Published: 2017

50. Enhanced performance of AlGaN-based ultraviolet light-emitting diodes with linearly graded AlGaN inserting layer in electron blocking layer*

Author: Qi-Bao Wu, He Longfei, Jian Jiang, Guang Li, Jiaqi Guo, Weidong Song, Xingjun Luo, Shuti Li, Linyuan Wang, and Zhang Kang
Subjects: Materials science, business.industry, Ultraviolet light emitting diodes, General Physics and Astronomy, Optoelectronics, Quantum efficiency, business, Electron blocking layer, Layer (electronics)
Abstract: The conventional stationary Al content AlGaN electron blocking layer (EBL) in ultraviolet light-emitting diode (UV LED) is optimized by employing a linearly graded AlGaN inserting layer which is 2.0 nm Al0.3Ga0.7N/5.0 nm Al x Ga1−x N/8.0 nm Al0.3Ga0.7N with decreasing value of x. The results indicate that the internal quantum efficiency is significantly improved and the efficiency droop is mitigated by using the proposed structure. These improvements are attributed to the increase of the effective barrier height for electrons and the reduction of the effective barrier height for holes, which result in an increased hole injection efficiency and a decreased electron leakage into the p-type region. In addition, the linearly graded AlGaN inserting layer can generate more holes in EBL due to the polarization-induced hole doping and a tunneling effect probably occurs to enhance the hole transportation to the active regions, which will be beneficial to the radiative recombination.
Published: 2019

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