1. Maurice Raynaud (1834–1881) und das Mysterium 'Raynaud-Phänomen'
- Author
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Niklas Koehler, Ulrich Koehler, Olaf Hildebrandt, and Irene Portig
- Subjects
030203 arthritis & rheumatology ,medicine.medical_specialty ,Primary Raynaud Phenomenon ,integumentary system ,business.industry ,Medical school ,Vasospasm ,Sympathetic activity ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Scleroderma ,body regions ,Raynaud phenomenon ,03 medical and health sciences ,0302 clinical medicine ,Color changes ,Selective stimulation ,Internal medicine ,medicine ,Cardiology ,cardiovascular diseases ,skin and connective tissue diseases ,business - Abstract
Maurice Raynaud first described color changes and symptoms of the fingers due to cold-induced vasospasm and restricted blood flow in his medical school thesis in 1862. Raynaud’s phenomenon is common and exists as an uncomplicated primary Raynaud phenomenon and a Raynaud phenomenon secondary to underlying diseases and medication. Mechanisms contributing to altered vasoconstrictor activity are endothelial and not-endothelial. Cold-induced vasospasm is probably a thermoregulatory problem and effects are mediated by sympathetic activity and selective stimulation of alpha2c-adrenoreceptors.
- Published
- 2019