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1. Real-world antithrombotic treatment variability in patients undergoing peripheral vascular intervention: Insights from the VQI registry

Author: Zain Ahmed, Edouard Aboian, Jiaming Huang, Poghni A. Peri-Okonny, Qurat-ul-ain Jelani, Kim G. Smolderen, Megan Lee, and Carlos Mena-Hurtado
Subjects: medicine.medical_specialty, business.industry, Dual Anti-Platelet Therapy, Psychological intervention, Odds ratio, Evidence-based medicine, Confidence interval, Antithrombotic treatment, Treatment Outcome, Fibrinolytic Agents, Risk Factors, Internal medicine, Antithrombotic, Humans, Medicine, In patient, Registries, Medical prescription, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract: For those undergoing peripheral vascular interventions (PVI), guidelines indicate the use of dual antiplatelet therapy (DAPT) is reasonable (Class IIb), but recommendations have not reached the highest level of evidence. In the largest effort to date, we found that antithrombotic prescription was dominated by single antiplatelet therapy (SAPT) (51.4%) before PVI, which switched to DAPT (57.7%) following PVI, with some patients still remaining on no therapy (8%). High site variability in prescription rates (median odds ratio: 1.40, 95% confidence interval: 1.32, 1.48) was not much explained by patient and provider factors, revealing a need for the creation and integration of the newest trial data and for interventions at the health system or practice level to help physicians determine the optimal medical therapy following PVI.
Published: 2022
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2. Design, simulation, and analysis using 316 stainless-steel alloy based automatic protection guard for bike

Author: P.S. Rama Sreekanth, Ankan Narayan Biswas, Nunna Mahesh, and Shanmukha Ram Peri
Subjects: Mechanism (engineering), Guard (information security), Motion analysis, Mode (computer interface), Tilt sensor, Position (vector), Spring (device), Computer science, business.industry, Structural engineering, Deformation (meteorology), business
Abstract: An automatic protection guard for bikes reduces the impact to the side panels, engine, and the rider's leg when the bike collides with the ground, which follows the reverse quick return mechanism. Include a tilt sensor to monitor the bike's lean angle to activate the system and a wave spring inside the hollow bars to absorb the impact. A tilt sensor will be installed and will set a lean angle to the system. When the bike crosses the calibrated lean angle, the system activates and releases the bars from the system installed onto the bike frame and will take the first contact with the ground surface. To match real-life situations, the time taken for the protection guards to move from initial position to extreme position has been calculated using solid Works motion analysis with an average time taken is 0.14 s, and to find the total deformation different loads and different spring constants have been applied using Ansys software the average deformation is 12 mm. The system helps the rider to ride the bike in a safe mode. The total design system is dynamic and varies with the bike segment but follows the same mechanism.
Published: 2022
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3. My OR goes green: Surgery and sustainability

Author: Alba Muzzi, Andrea Peri, Matteo Filardo, Luigi Pugliese, Stefania Marconi, and Andrea Pietrabissa
Subjects: Conservation of Natural Resources, business.industry, Sustainability, General Engineering, Humans, Medicine, Surgery, Environmental ethics, business
Published: 2022
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4. Effect of the thermal storage dimensions on the performances of solar photovoltaic-thermal systems

Author: Cristina Malara, Laura Cirrincione, Antonino Nucara, Giorgia Peri, Matilde Pietrafesa, Concettina Marino, Cirrincione, L., Malara, C., Marino, C., Nucara, A., Peri, G., and Pietrafesa, M.
Subjects: Settore ING-IND/11 - Fisica Tecnica Ambientale, 060102 archaeology, Renewable Energy, Sustainability and the Environment, business.industry, Computer science, 020209 energy, Photovoltaic system, Context (language use), 06 humanities and the arts, 02 engineering and technology, Thermal energy storage, Solar energy, Automotive engineering, Storage tank, Thermal, Photovoltaic-thermal (PV/T) system, Thermal storage, 0202 electrical engineering, electronic engineering, information engineering, 0601 history and archaeology, business, Electrical efficiency, Thermal energy
Abstract: PV/T panels are innovative systems increasingly used in the building sector. As a matter of fact, in that context they allow a set of common problems to be addressed and often solved: lack of physical space and economic issues, always existing when PV and thermal panels are to be installed separately. Obviously, the main objective of PV/T panels is to enhance the electrical efficiency by cooling the PV cells, but the side positive effect is also the production of thermal energy, which can be suitably exploited with a proper configuration of the whole system and an appropriate design of its components. Their energy production and overall efficiency depend on several factors and therefore the effect of different system features should be investigated. In this work, a parametric analysis was performed to provide a contribution on this topic. The effects of the characteristics of the thermal storage on electrical and thermal system performances were analysed, also considering the influence of the thermal load magnitude. The conclusive considerations can be exploited by designers and researchers to maximize the efficiency of the systems in relation to the storage tank characteristics and both electrical and thermal loads.
Published: 2020
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5. Istaroxime Metabolite PST3093 Selectively Stimulates SERCA2a and Reverses Disease-Induced Changes in Cardiac Function

Author: Paolo Barassi, SC Hsu, Mara Ferrandi, Marcella Rocchetti, Giuseppe Bianchi, Antonio Zaza, Gwo-Jyh Chang, Francesco Peri, Martina Arici, Carlotta Ronchi, Luraghi A, Patrizia Ferrari, Eleonora Torre, Arici, M, Ferrandi, M, Barassi, P, Hsu, S, Torre, E, Luraghi, A, Ronchi, C, Chang, G, Peri, F, Ferrari, P, Bianchi, G, Rocchetti, M, and Zaza, A
Subjects: Cardiac function curve, Digoxin, Physiology, Metabolite, Cardiomyopathy, SERCA2, istaroxime, heart failure, diastolic dysfunction, metabolite, Pharmacology, Sarcoplasmic Reticulum Calcium-Transporting ATPases, chemistry.chemical_compound, Pharmacokinetics, BIO/09 - FISIOLOGIA, Etiocholanolone, Medicine, Humans, Animals, Myocytes, Cardiac, Heart Failure, Adenosine Triphosphatases, business.industry, Heart, medicine.disease, Rats, Istaroxime, chemistry, Pharmacodynamics, Heart failure, Molecular Medicine, business, medicine.drug
Abstract: BackgroundHeart failure (HF) therapeutic toolkit would strongly benefit from the availability of ino-lusitropic agents with a favorable pharmacodynamics and safety profile. Istaroxime is a promising agent, which combines Na+/K+ pump inhibition with SERCA2a stimulation; however, it has a very short half-life and extensive metabolism to a molecule, named PST3093. The present work aims to investigate whether PST3093, still retains the pharmacodynamic and pharmacokinetic properties of its parent compound.MethodsWe studied PST3093 for its effects on SERCA2a and Na+/K+ ATPase activities, Ca2+ dynamics in isolated myocytes and hemodynamic effects in an in-vivo rat model of diabetic (streptozotocin (STZ)-induced) cardiomyopathy.ResultsIstaroxime infusion in HF patients led to accumulation of PST3093 in the plasma; clearance was substantially slower for PST3093 than for istaroxime. In cardiac rat preparations PST3093 did not inhibit the Na+/K+ ATPase activity, but retained SERCA2a stimulatory activity. In in-vivo echocardiographic assessment, PST3093 improved overall cardiac performance and reversed most STZ-induced abnormalities. PST3093 i.v. toxicity was considerably lower than that of istaroxime and it failed to significantly interact with 50 off-targets.ConclusionsOverall, PST3093 is a “selective” SERCA2a activator, the prototype of a novel pharmacodynamic category with a potential in the ino-lusitropic approach to HF with prevailing diastolic dysfunction. Its pharmacodynamics are peculiar and its pharmacokinetics are suitable to prolong the cardiac beneficial effect of istaroxime infusion.Graphical abstract
Published: 2022

6. Rheumatoid arthritis patients treated with Janus kinase inhibitors show reduced humoral immune responses following BNT162b2 vaccination

Author: Aharon Kessel, Liat Iancovici, Yotam Bar-On, Ofer Harel, Gleb Slobodin, Yoav Hazan, Dina Khateeb, Regina Peri, and Doron Melamed
Subjects: rheumatoid arthritis, Antibodies, Viral, Arthritis, Rheumatoid, Immune system, Rheumatology, medicine, antibodies, Humans, Pharmacology (medical), AcademicSubjects/MED00360, BNT162 Vaccine, B cell, Janus kinase inhibitors, B cells, biology, SARS-CoV-2, business.industry, Vaccination, COVID-19, Germinal center, vaccines, medicine.disease, Antibodies, Neutralizing, Immunity, Humoral, medicine.anatomical_structure, Immunoglobulin G, Rheumatoid arthritis, Spike Glycoprotein, Coronavirus, Humoral immunity, Immunology, biology.protein, Original Article, Antibody, Janus kinase, business
Abstract: Objectives The mRNA-based COVID-19 vaccines are now employed globally and have shown high efficacy in preventing SARS-CoV-2 infection. However, less is known about the vaccine efficacy in immune-suppressed individuals. This study sought to explore whether humoral immunity to the COVID-19 vaccine BNT162b2 is altered in RA patients treated with Janus kinase inhibitors by analysing their antibodies titre, neutralization activity and B cell responses. Methods We collected plasma samples from 12 RA patients who were treated with Janus kinase inhibitors and received two doses of the BNT162b2 vaccine, as well as 26 healthy individuals who were vaccinated with the same vaccine. We analysed the quantity of the anti-spike IgG and IgA antibodies that were elicited following the BNT162b2 vaccination, the plasma neutralization capacity and the responsiveness of the B-lymphocytes. We used ELISA to quantify the antibody titres, and a plasma neutralization assay was used to determine the virus neutralization capacity. Alteration in expression of the genes that are associated with B cell activation and the germinal centre response were analysed by quantitative PCR. Results Reduced levels of anti-spike IgG antibodies and neutralization capacity were seen in the RA patients who were treated with JAK inhibitors in comparison with healthy individuals. Furthermore, B cell responsiveness to the SARS-CoV-2 spike protein was reduced in the RA patients. Conclusion RA patients who are treated with JAK inhibitors show a suppressed humoral response following BNT162b2 vaccination, as revealed by the quantity and quality of the anti-spike antibodies.
Published: 2021
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7. The association between elevated serum interleukin‐22 and the clinical diagnosis of axial spondyloarthritis: A retrospective study

Author: Mohammad Adawi, Abid Awisat, Aniela Shouval, Aharon Kessel, Michal Sagiv, Regina Peri, Firas Sabbah, Itzhak Rosner, and Gleb Slobodin
Subjects: Adult, Male, medicine.medical_specialty, Enzyme-Linked Immunosorbent Assay, Osteoarthritis, Sensitivity and Specificity, Interleukin 22, Rheumatology, Predictive Value of Tests, Internal medicine, Humans, Medicine, Axial spondyloarthritis, Medical diagnosis, BASDAI, Aged, Retrospective Studies, Ankylosing spondylitis, business.industry, Interleukins, Retrospective cohort study, Middle Aged, medicine.disease, Biomarker (medicine), Female, business, Axial Spondyloarthritis, Biomarkers
Abstract: OBJECTIVE There is an unmet need for a reliable biomarker for the differentiation of axial spondyloarthritis (AxSpA) from its mimickers. Serum levels of interleukin-22 (IL-22) have previously been found to be significantly elevated in patients with AxSpA compared with healthy individuals or persons with osteoarthritis. METHODS Consecutive patients with established or suspected AxSpA were enrolled. The clinical data, as well as results of laboratory and imaging studies, were acquired from patients' charts. The final diagnosis of definite or probable SpA, or an alternative diagnosis, was determined, and the serum levels of IL-22 were examined by enzyme-linked immunosorbent immunoassay. RESULTS Interleukin-22 levels were significantly higher in patients with definite AxSpA (29 patients) compared with patients with alternative diagnoses (14 patients) and healthy volunteers (16 individuals; P
Published: 2021
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8. Patients Undergoing Bariatric Surgery: a Special Risk Group for Lifestyle, Emotional and Behavioral Adaptations During the COVID-19 Lockdown. Lessons from the First Wave

Author: Amadeu Obach, Josep Vidal, Silvia Cañizares, Judit Molero, Carla Mestre, Lilliam Flores, Violeta Moizé, Josep M Peri, Alba Andreu, Ferran Torres, and Ricard Navinés
Subjects: Adult, Male, medicine.medical_specialty, Original Contributions, Endocrinology, Diabetes and Metabolism, Population, Substance use, Risk Factors, Lockdown, medicine, Humans, Obesity, education, Life Style, Pandemics, Depression (differential diagnoses), Bariatric surgery, education.field_of_study, Nutrition and Dietetics, SARS-CoV-2, business.industry, COVID-19, Middle Aged, Emotional eating, medicine.disease, Mental health, Obesity, Morbid, Surgery, Cross-Sectional Studies, Sleep Quality, Telephone interview, Communicable Disease Control, Anxiety, Female, medicine.symptom, business, Weight gain
Abstract: Objectives To determine how the COVID-19 lockdown influenced the lifestyle, eating behavior, use of substances, mental health, and weight in patients who had undergone bariatric surgery (BS) and explore the self-perception of one’s own health and fears related to COVID-19. Methods We performed a cross-sectional exploratory study in obesity patients who had undergone BS surgery > 1 year previously in a university hospital. Assessment was performed 40 days after initiating lockdown and included 2 periods: from April 24 until May 8 and during the initial de-escalation period: from May 9 until 22, 2020. A structured telephone interview and an online survey were administered. Results One hundred eighty-eight patients were interviewed; 156 also responded to the online survey (77% females, mean age 53.46 ± 10.48 years, mean follow-up 5.71 ± 4.30 years). Dietary habits were affected in 72% of the participants, with 15% reporting better diet planning; 83.5% reported having more sedentary behaviors; 27% and 36% showed depression and anxiety, respectively; and 45% of participants reported bad sleep quality. In relation to changes in the use of any substance, the use increased in the majority of patients who were previously users. Self-perception of one’s own health and fears related to COVID-19 were only moderate. Finally, emotional eating and time since BS were statistically significant risk factors for predicting weight gain. Conclusions Lockdown during COVID-19 pandemic negatively influenced the lifestyle, mental health, substance use, and weight in BS patients. These alterations were somewhat similar to those observed in the general population but more severe and with important clinical implications. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11695-021-05792-1.
Published: 2021
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9. Selective area regrowth and doping for vertical gallium nitride power devices: Materials challenges and recent progress

Author: Jung Han, Kai Fu, Andrew M. Armstrong, Hong Chen, Chen Yang, Andrew A. Allerman, Hanxiao Liu, Xuguang Deng, Shanthan Reddy Alugubelli, Tae Hyeon Kim, Houqiang Fu, Fernando Ponce, Prudhvi Peri, David J. Smith, Edward T. Yu, Po Yi Su, Daniel C. Messina, Jingan Zhou, Chi-Yin Cheng, Xuanqi Huang, Robert J. Nemanich, Stephen M. Goodnick, Dinusha Herath Mudiyanselage, Kevin Hatch, Yuji Zhao, Tsung-Han Yang, Bingjun Li, and Reza Vatan Meidanshahi
Subjects: Materials science, Scanning electron microscope, business.industry, Mechanical Engineering, Doping, Gallium nitride, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Electron holography, 0104 chemical sciences, chemistry.chemical_compound, Scanning probe microscopy, chemistry, Mechanics of Materials, Etching (microfabrication), Optoelectronics, General Materials Science, Dry etching, 0210 nano-technology, business, Leakage (electronics)
Abstract: This paper reviews materials challenges and recent progress for selective area regrowth and doping for vertical gallium nitride (GaN) power devices. The purpose is to realize randomly placed, reliable, contactable, and generally useable laterally patterned p-n junctions, which are the building blocks for various advanced power rectifiers and transistors. The general regrowth process and regrowth dynamics in trenches were discussed, where the effects of trench geometries, growth methods, and bulk substrates were elucidated. Comprehensive materials characterization techniques were utilized to analyze the regrown structures, including scanning electron microscopy, transmission electron microscopy, atom probe tomography, scanning probe microscopy, and secondary-ion mass spectrometry. Cathodoluminescence and secondary electrons in scanning electron microscopy and atom probe tomography were used to achieve lateral and vertical dopant profiling at a sub-micron scale. The regrowth interface after dry etching accumulated a high density of impurities and charges, contributing to the formation of a p+-n+ tunneling junction. This hypothesis was further confirmed by the electrostatic potential profile at the regrowth interface using electron holography. Novel etching technologies were investigated to improve the regrowth interface. It was found that low-power dry etching significantly reduced the interfacial charges and the reverse leakage currents of regrown p-n junctions. Photoelectrochemical wet etching was found to be effective in reducing deep-level defects near the regrowth interface. Atomic layer etching uses self-limiting chemical processes, thus removing the damaged layers without inducing further etching damage. Tertiarybutylchloride-based in situ etching may serve as an alternative etching method to dry etching with reduced etching damage. In terms of devices, regrown p-n junctions with low leakage currents and vertical junction field-effect transistors were demonstrated. Further improvements in selective area regrowth and associated devices can be expected using regrowth optimization and regrowth interface engineering via surface treatments and low-damage etching. These results represent an important step towards realizing selective area regrowth and doping for high performance GaN power electronics devices and systems.
Published: 2021
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10. Coaching Program in Detention Centers as Process of Preparing Inmate Life Skills

Author: Alim Harun Pamungkas and Peri Aldaus
Subjects: Medical education, business.industry, Process (engineering), Literature study, Life skills, business, Psychology, Coaching, Period (music), Sentence
Abstract: This paper is motivated by the challenges that will be faced by former prisoners when returning to society. The purpose of this paper to describe to the coaching program aimed at prisoners who are in detention centers. This paper used a literature study method by collecting data related to the topic of articles obtained from various sources. Search for published articles using the selected keywords. Articles or journals that match the inclusion and exclusion criteria are taken for further analysis. The concludes of this paper that coaching is divided into stages, namely the initial stage, which is calculated from the initial time of entry up to one-third of the criminal period. Meanwhile, the first stage of development is a third to half of the sentence. Next is the second development stage, namely half to the end of the criminal period. These three stages constitute an effective system.
Published: 2021
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11. Evaluating the Transvaginal Ultrasound Diagnostic Criteria for Abnormal First-Trimester Pregnancy With Follow-Up Into the Third Trimester and Validation of Results

Author: Mostafa Atri, Abdullah Alabousi, Peri Abdullah, Jamil A.K. Addas, and Khaled Almohaimede
Subjects: medicine.medical_specialty, Heartbeat, Pregnancy Trimester, Third, First trimester pregnancy, Ultrasonography, Prenatal, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Heart rate, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Yolk sac, Retrospective Studies, Yolk Sac, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics, Ultrasound, Pregnancy Outcome, Obstetrics and Gynecology, medicine.disease, Pregnancy Trimester, First, Transvaginal ultrasound, medicine.anatomical_structure, embryonic structures, Cohort, Female, business, Follow-Up Studies
Abstract: Objective To evaluate the current ultrasound diagnostic criteria for non-viable pregnancy in the first trimester. Methods We conducted a retrospective chart review involving 3 tertiary care institutions. Consecutive first-trimester ultrasound reports between January 2013 and June 2016 were reviewed. All first-trimester ultrasound examinations performed to assess pregnancy viability with adequate imaging or clinical follow-up were included. Inclusion criteria based on follow-up were adequate imaging to document ongoing intrauterine pregnancy or clinical follow-up demonstrating viability or non-viability. Data on mean sac diameter (MSD), yolk sac presence/diameter, embryo presence/length, presence of a heartbeat, and heart rate were collected. This was followed by a retrospective validation review of another consecutive cohort. Results Two hundred and forty-five examinations with a viable-pregnancy outcome and 301 examinations with a non-viable pregnancy outcome were reviewed. The main predictor of non-viable pregnancy was an MSD of ≥20 mm in the absence of a yolk sac (positive predictive value [PPV] 100%; 95% CI 93%–100%), embryo (PPV 100%; 95% CI 90%–100%), or heartbeat (PPV 100%; 95% CI 96%–100%]). Other predictors of non-viability were a measurable embryo without a yolk sac (PPV 100%; 95% CI 91%–100%), yolk sac diameter ≥8 mm (PPV 100%; 95% CI 91%–100%), and absence of heartbeat with an embryo ≥3 mm (PPV 100%; 95% CI 97%–100%). These findings were confirmed in a validation cohort of 45 viable and 53 non-viable pregnancies, with the exception of 1 case of viable pregnancy with no heartbeat and an embryo length 3.3 mm. Based on the median daily growth of 1.2 mm in the viable cohort, 21% of follow-up ultrasound examinations were performed too early for an MSD threshold of 20 mm and 55%, for an MSD threshold of 25 mm. Conclusion In our cohort, MSD ≥20 mm in the absence of yolk sac or an embryo with heartbeat always predicted a non-viable pregnancy.
Published: 2021
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12. Successful Treatment of Suspected Donor-derived Human Herpesvirus-8 Infection in a Liver Transplant Patient With Coronavirus Disease-19

Author: Lorena van den Bogaart, Marco Rizzi, Alessandra Tebaldi, Andrea Gianatti, Alessia Dalla Pria, Fabrizio Fabretti, Paolo Giuffrida, And Stefano Fagiuoli, Bianca Magro, Anna Maria Barbui, Anna Maria Peri, Peri, A, Magro, B, Van Den Bogaart, L, Pria, A, Giuffrida, P, Gianatti, A, Fabretti, F, Barbui, A, Tebaldi, A, Rizzi, M, and Fagiuoli, S
Subjects: Transplantation, business.industry, medicine.medical_treatment, coronavirus disease-19, Disease, Liver transplantation, medicine.disease_cause, medicine.disease, Virology, liver transplant, Herpesviridae Infections, Cytokine release syndrome, human herpesvirus-8, Carcinoma, Medicine, Rituximab, Transplant patient, business, medicine.drug, Coronavirus
Published: 2021
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13. Effect of chemical modulation of toll-like receptor 4 in an animal model of ulcerative colitis

Author: Francesca Granucci, Ivan Monteleone, Francesco Peri, Simona Barresi, Alberto Minotti, Giovanni Monteleone, Andrea Luraghi, Davide Di Fusco, Fabio A. Facchini, Facchini, F, Di Fusco, D, Barresi, S, Luraghi, A, Minotti, A, Granucci, F, Monteleone, G, Peri, F, and Monteleone, I
Subjects: Male, Receptor complex, Lipopolysaccharide, Lipopolysaccharide (LPS), 030226 pharmacology & pharmacy, Inflammatory bowel disease, Settore MED/12, Mice, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Pharmacology (medical), 030212 general & internal medicine, Intestinal Mucosa, Cells, Cultured, Toll-like receptor, Crohn disease, General Medicine, Middle Aged, Ulcerative colitis, Synthetic small molecule, 3. Good health, Inflammatory bowel disease (IBD), Synthetic small molecules, Toll-like receptor 4 (TLR4), Cytokines, Female, medicine.symptom, Adult, Colon, Inflammation, Peripheral blood mononuclear cell, Young Adult, 03 medical and health sciences, Animals, Humans, Pharmacology, Ulcerative coliti, business.industry, Inflammatory Bowel Diseases, medicine.disease, Toll-Like Receptor 4, Disease Models, Animal, CHIM/08 - CHIMICA FARMACEUTICA, chemistry, Immunology, Leukocytes, Mononuclear, TLR4, Colitis, Ulcerative, Glycolipids, business
Abstract: Purpose: The partial ineffectiveness and side effects of inflammatory bowel disease (IBD) current therapies drive basic research to look for new therapeutic target in order to develop new drug lead. Considering the pivotal role played by toll-like receptors (TLRs) in gut inflammation, we evaluate here the therapeutic effect of the synthetic glycolipid TLR4 antagonist FP7. Methods: The anti-inflammatory effect of FP7, active as TLR4 antagonist, was evaluated on peripheral blood mononuclear cells (PBMCs) and lamina propria mononuclear cells (LPMCs) isolated from IBD patients, and in a mouse model of ulcerative colitis. Results: FP7 strongly reduced the inflammatory responses induced by lipopolysaccharide (LPS) in vitro, due to its capacity to compete with LPS for the binding of TLR4/MD-2 receptor complex thus inhibiting both the MyD88- and TRIF-dependent inflammatory pathways. Colitic mice treated with FP7 exhibit reduced colonic inflammation and decreased levels of pro-inflammatory cytokines. Conclusions: This study suggests that TLR4 chemical modulation can be an effective therapeutic approach to IBD. The selectivity of FP7 on TLR4 makes this molecule a promising drug lead for new small molecules-based treatments.
Published: 2020
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14. Two operative risk indicators as tools for negotiating contracts between curators of Museums and HVAC technical services providers

Author: Gianluca Scaccianoce, Laura Cirrincione, Gianfranco Rizzo, Antonino Nucara, Giorgia Peri, Cirrincione, Laura, Nucara, Antonino, Peri, Giorgia, Rizzo, Gianfranco, and Scaccianoce, Gianluca
Subjects: Archeology, Environmental condition, Materials Science (miscellaneous), media_common.quotation_subject, Control (management), Psychological intervention, Conservation, Stipulation, Works of art preservation, HVAC, Risk indexe, Museum, Economic cost, HVAC management and maintenance service contract, Spectroscopy, media_common, Settore ING-IND/11 - Fisica Tecnica Ambientale, business.industry, Negotiation, Work (electrical), Risk analysis (engineering), Chemistry (miscellaneous), Order (business), Damages, business, General Economics, Econometrics and Finance
Abstract: The purpose of Heating, Ventilating and Air-Conditioning (HVAC) systems in museums is to properly control important microclimate parameters; such systems, in fact, apart from ensuring the visitors’ wellbeing, are requested to guarantee suitable indoor conditions for the proper conservation of the important cultural goods hosted by museums. Hence, in case of disservice, or interruption due to maintenance interventions, it is important to quantify the economic damage induced to exhibited and/or stored works of art (or even to the building museum itself). Accordingly, it is essential to guarantee the shortest possible period of disservice during which probable damages for the works of art could occur. Since curators are the most relevant subjects committed to properly run the museum, also for what concerns the indoor environmental conditions, the aim of this work is to propose two new comprehensive operative damage risk indicators to support curators in negotiating the stipulation of contracts with the external companies in charge of the management of the HVAC system, in order to preserve the works of art. Particularly, these indicators try to integrate, into the contracts, economic considerations related to the system's disservice period and/or planned interruptions. The feasibility of the proposed new indicators has been checked by means of an example application involving the “Museo Regionale” of Palermo (Italy).
Published: 2020
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15. Clinical factors associated with death in 3044 COVID-19 patients managed in internal medicine wards in Italy: comment

Author: Bandera, A., Nobili, A., Tettamanti, M., Harari, S., Bosari, S., Mannucci, P. M., Scudeller, L., Fusetti, G., Rusconi, L., Dell'Orto, S., Prati, D., Valenti, L., Giovannelli, S., Manunta, M., Lamorte, G., Ferrari, F., Gori, A., Muscatello, A., Mangioni, D., Alagna, L., Bozzi, G., Lombardi, A., Ungaro, R., Ancona, G., Zuglian, G., Bolis, M., Iannotti, N., Ludovisi, S., Comelli, A., Renisi, G., Biscarini, S., Castelli, V., Palomba, E., Fava, M., Fortina, V., Peri, C. A., Saltini, P., Viero, G., Itri, T., Ferroni, V., Pastore, V., Massafra, R., Liparoti, A., Muheberimana, T., Giommi, A., Bianco, R., De Azevedo, R. M., Chitani, G. E., Peyvandi, F., Gualtierotti, R., Ferrari, B., Rossio, R., Boasi, N., Pagliaro, E., Massimo, C., De Caro, M., Montano, N., Vigone, B., Bellocchi, C., Carandina, A., Fiorelli, E., Melli, V., Tobaldini, E., Blasi, F., Aliberti, S., Spotti, M., Terranova, L., Misuraca, S., D'Adda, A., Della Fiore, S., Di Pasquale, M., Contarini, M. M. M., Ori, M., Morlacchi, L., Rossetti, V., Gramegna, A., Pappalettera, M., Cavallini, M., Buscemi, A., Vicenzi, M., Rota, I., Costantino, G., Solbiati, M., Furlan, L., Mancarella, M., Colombo, G., Fanin, A., Passarella, M., Monzani, V., Canetta, C., Rovellini, A., Barbetta, L., Billi, F., Folli, C., Accordino, S., Maira, D., C. M., Hu, Motta, I., Scaramellini, N., Fracanzani, A. L., Lombardi, R., Cespiati, A., Cesari, M., Lucchi, T., Proietti, M., Calcaterra, L., Mandelli, C., Coppola, C., Cerizza, A., Pesenti, A. M., Grasselli, G., Galazzi, A., Monti, I., Galbussera, A. A., Crisafulli, E., Girelli, D., Maroccia, A., Gabbiani, D., Busti, F., Vianello, A., Biondan, M., Sartori, F., Faverio, P., Pesci, A., Zucchetti, S., Bonfanti, P., Rossi, M., Beretta, I., Spolti, A., Elia, D., Cassandro, R., Caminati, A., Cipollone, F., Guagnano, M. T., D'Ardes, D., Rossi, I., Vezzani, F., Spanevello, A., Cherubino, F., Visca, D., Contoli, M., Papi, A., Morandi, L., Battistini, N., Moreo, G. L., Iannuzzi, P., Fumagalli, D., Leone, S., Bandera, A, Nobili, A, Tettamanti, M, Harari, S, Bosari, S, Mannucci, P, Scudeller, L, Fusetti, G, Rusconi, L, Dell'Orto, S, Prati, D, Valenti, L, Giovannelli, S, Manunta, M, Lamorte, G, Ferrari, F, Gori, A, Muscatello, A, Mangioni, D, Alagna, L, Bozzi, G, Lombardi, A, Ungaro, R, Ancona, G, Zuglian, G, Bolis, M, Iannotti, N, Ludovisi, S, Comelli, A, Renisi, G, Biscarini, S, Castelli, V, Palomba, E, Fava, M, Fortina, V, Peri, C, Saltini, P, Viero, G, Itri, T, Ferroni, V, Pastore, V, Massafra, R, Liparoti, A, Muheberimana, T, Giommi, A, Bianco, R, De Azevedo, R, Chitani, G, Peyvandi, F, Gualtierotti, R, Ferrari, B, Rossio, R, Boasi, N, Pagliaro, E, Massimo, C, De Caro, M, Montano, N, Vigone, B, Bellocchi, C, Carandina, A, Fiorelli, E, Melli, V, Tobaldini, E, Blasi, F, Aliberti, S, Spotti, M, Terranova, L, Misuraca, S, D'Adda, A, Della Fiore, S, Di Pasquale, M, Contarini, M, Ori, M, Morlacchi, L, Rossetti, V, Gramegna, A, Pappalettera, M, Cavallini, M, Buscemi, A, Vicenzi, M, Rota, I, Costantino, G, Solbiati, M, Furlan, L, Mancarella, M, Colombo, G, Fanin, A, Passarella, M, Monzani, V, Canetta, C, Rovellini, A, Barbetta, L, Billi, F, Folli, C, Accordino, S, Maira, D, Hu, C, Motta, I, Scaramellini, N, Fracanzani, A, Lombardi, R, Cespiati, A, Cesari, M, Lucchi, T, Proietti, M, Calcaterra, L, Mandelli, C, Coppola, C, Cerizza, A, Pesenti, A, Grasselli, G, Galazzi, A, Monti, I, Galbussera, A, Crisafulli, E, Girelli, D, Maroccia, A, Gabbiani, D, Busti, F, Vianello, A, Biondan, M, Sartori, F, Faverio, P, Pesci, A, Zucchetti, S, Bonfanti, P, Rossi, M, Beretta, I, Spolti, A, Elia, D, Cassandro, R, Caminati, A, Cipollone, F, Guagnano, M, D'Ardes, D, Rossi, I, Vezzani, F, Spanevello, A, Cherubino, F, Visca, D, Contoli, M, Papi, A, Morandi, L, Battistini, N, Moreo, G, Iannuzzi, P, Fumagalli, D, and Leone, S
Subjects: Adult, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Critical Care, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Ce - Letter to the Editor, MEDLINE, Cohort Studies, Hospital, Internal Medicine, Medicine, Humans, Hospital Mortality, Intensive care medicine, Aged, Aged, 80 and over, business.industry, SARS-CoV-2, COVID-19, Middle Aged, Respiration, Artificial, Hospitals, Hospitalization, Survival Rate, Italy, Emergency Medicine, business, Human
Abstract: During the COVID-19 2020 outbreak, a large body of data has been provided on general management and outcomes of hospitalized COVID-19 patients. Yet, relatively little is known on characteristics and outcome of patients managed in Internal Medicine Units (IMU). To address this gap, the Italian Society of Internal Medicine has conducted a nationwide cohort multicentre study on death outcome in adult COVID-19 patients admitted and managed in IMU. This study assessed 3044 COVID-19 patients at 41 referral hospitals across Italy from February 3rd to May 8th 2020. Demographics, comorbidities, organ dysfunction, treatment, and outcomes including death were assessed. During the study period, 697 patients (22.9%) were transferred to intensive care units, and 351 died in IMU (death rate 14.9%). At admission, factors independently associated with in-hospital mortality were age (OR 2.46, p = 0.000), productive cough (OR 2.04, p = 0.000), pre-existing chronic heart failure (OR 1.58, p = 0.017) and chronic obstructive pulmonary disease (OR 1.17, p = 0.048), the number of comorbidities (OR 1.34, p = 0.000) and polypharmacy (OR 1.20, p = 0.000). Of note, up to 40% of elderly patients did not report fever at admission. Decreasing PaO
Published: 2022

16. A well-appearing infant with a sudden anisocoria

Author: Roberto Dall'Amico, Laura Diplotti, Andrew Tenore, Egidio Barbi, Alessia Giuseppina Servidio, Laura Cesca, Francesca Peri, Servidio, A. G., Peri, F., Tenore, A., Cesca, L., Diplotti, L., Dall'Amico, R., and Barbi, E.
Subjects: Male, Child abuse, Pediatrics, medicine.medical_specialty, child abuse, Vital signs, Mothers, Physical examination, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Mydriasis, medicine, Humans, Medical history, Child, Anisocoria, medicine.diagnostic_test, business.industry, Brain, Infant, Emergency department, ophthalmology, toxicology, Pediatrics, Perinatology and Child Health, 030221 ophthalmology & optometry, Female, Presentation (obstetrics), medicine.symptom, Sleep, business
Abstract: Case presentationA 10-month-old boy was admitted to the emergency department due to a sudden onset of left unilateral mydriasis (figure 1). His medical history was unremarkable. A minor head trauma 2 days before was reported, without alarming signs or symptoms. His mother was putting him to sleep, after coming back from work, when she noticed a different pupil size and promptly went to the ED with her husband. The parents denied any use of medications, including nebulised therapy or direct contact with plants. The child was well appearing and his vital signs were within the standard age limits. His extraocular motility was normal as well as the rest of his neurological and physical examination. Parents’ behaviour was somehow remarkable. Even though the child was not suffering, the mother seemed very worried while the father was nervous and aggressive, repeatedly asking for a discharge.Figure 1Left unilateral mydriasis.QuestionsWhat is the most likely diagnosis based on this clinical presentation?Local contact with a mydriatic substanceIntracerebral haemorrhageBrain tumourThird nerve palsyWhat would be the next step in the investigation to confirm this diagnosis?Brain CTBrain MRIFundus oculi examinationToxicological screening of urineHow is this condition managed, and what is the prognosis?Answers can be found on page XX
Published: 2022

17. Enhancement-Mode Gate-Recess-Free GaN-Based p-Channel Heterojunction Field-Effect Transistor With Ultra-Low Subthreshold Swing

Author: Kai Fu, Chen Yang, Yuji Zhao, Prudhvi Peri, Jossue Montes, Tsung-Han Yang, Houqiang Fu, Jingan Zhou, and David J. Smith
Subjects: Materials science, Hydrogen, business.industry, Transistor, chemistry.chemical_element, Heterojunction, High-electron-mobility transistor, Electronic, Optical and Magnetic Materials, law.invention, Threshold voltage, chemistry, CMOS, law, Logic gate, Optoelectronics, Electrical and Electronic Engineering, business, Leakage (electronics)
Abstract: We report enhancement-mode ${p}$ -channel heterojunction field-effect transistors (HFETs) without gate recess on a standard ${p}$ -GaN/AlGaN/GaN high electron mobility transistor (HEMT) platform. The ${p}$ -GaN in the gate region was partially passivated by a low-power hydrogen plasma treatment process, and the remaining active ${p}$ -GaN and the underlying AlGaN formed the ${p}$ -channel. The device showed a record low off-state leakage of $ A/mm and subthreshold swing ( SS ) of 123.0 mV/dec with a threshold voltage ( ${V} _{\text {th}}$ ) of −0.6 V and high-temperature stability up to 200 °C. These results indicate that the hydrogen plasma treatment is beneficial for suppressing leakages and preserving excellent material quality in the ${p}$ -channel. With the success of the ${p}$ -HFETs, the ${p}$ -GaN/AlGaN/GaN platform can enable the monolithic integration of GaN ${n}$ - and ${p}$ -channel transistors without the need for regrowth. This work represents a significant step towards the implementation of the GaN CMOS technology.
Published: 2021
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18. Factors affecting compliance with positive airway pressure therapy in obstructive sleep apnea

Author: Şengül Cangür, Mehmet Fatih Elverisli, Peri Arbak, Ege Gulec Balbay, Merve Ercelik, Pınar Yıldız Gülhan, Fuat Aytekin, and [Belirlenecek]
Subjects: Adult, Male, medicine.medical_specialty, Resistance, Disorders of Excessive Somnolence, Trial, Pulmonary function testing, OSA, PFT, Therapy compliance, Internal medicine, Cpap Use, Positive airway pressure, medicine, Humans, Prospective Studies, Prospective cohort study, Sleep Apnea, Obstructive, Patient, Continuous Positive Airway Pressure, business.industry, Middle Aged, Abdominal distension, Vs, medicine.disease, respiratory tract diseases, Obstructive sleep apnea, PAP, Otorhinolaryngology, Adherence, Patient Compliance, Claustrophobia, Anxiety, Female, Neurology (clinical), Pulmonary-Function, Lung-Volumes, medicine.symptom, business, Compliance
Abstract: Objective To investigate the factors affecting compliance with positive airway pressure (PAP) therapy and establish the relationship between compliance and pulmonary function tests (PFT) in patients with OSA. Material and methods In this prospective study, patients with OSA using PAP devices were questioned about the complaints related to the device. Depression and anxiety scales along with PFT parameters were also assessed. Results Of 98 participants, 63% were men. The mean age was 52.0 +/- 9.6 years. Sixty-seven percent of the patients were compliant with their devices. A significant difference was observed between the proportion of the participants compliant or non-compliant with the device, based on OSA severity (p < 0.05). Beck depression inventory (BDI) and Beck anxiety inventory (BAI) scores of the compliant patients were significantly lower than those of the non-compliant patients (p < 0.001, p = 0.044, respectively). No statistically significant difference was detected between the groups regarding individual pulmonary function tests (p > 0.05). The rates of nasal mask use, not having difficulty in tolerating CPAP, falling asleep, absence of abdominal distension, no facial sores, no air leakage, patients benefiting from the device, reduction in daytime sleepiness, and the belief that they are receiving appropriate therapy in participants compliant with the device were higher than those in non-compliant participants (p < 0.05). The rates of claustrophobia and discomfort due to pressure were significantly lower in patients compliant with the device than in the non-compliant patients (p < 0.05). Conclusion While no relationship was detected between PFT parameters and PAP therapy compliance, significant factors affecting the device compliance were detected. WOS:000679638200001 2-s2.0-85111554942 PubMed: 34328605
Published: 2021
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19. Serum sodium alterations in SARS CoV-2 (COVID-19) infection: impact on patient outcome

Author: Andrea Ungar, Giulia Scocchera, Giovanni Corona, Gabriele Parenti, Benedetta Fibbi, Loredana Poggesi, Riccardo Pini, Adriano Peris, Carlo Nozzoli, Alessandro Bartoloni, Andrea Berni, Mario Maggi, Filippo Pieralli, Federico Lavorini, Alessandro Peri, Danilo Malandrino, and Andrea Fanelli
Subjects: Male, medicine.medical_specialty, Critical Care, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Sodium, chemistry.chemical_element, 030209 endocrinology & metabolism, Comorbidity, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Severity of illness, medicine, Humans, Hospital Mortality, Saline, Aged, Retrospective Studies, Aged, 80 and over, Fluorocarbons, Hypernatremia, Interleukin-6, SARS-CoV-2, business.industry, COVID-19, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Respiration, Artificial, Hydrocarbons, Brominated, Hospitalization, Pneumonia, Severe acute respiratory syndrome-related coronavirus, chemistry, 030220 oncology & carcinogenesis, Female, business, Hyponatremia
Abstract: Objective Hyponatremia is the most common electrolyte disorder in hospitalized patients and occurs in about 30% of patients with pneumonia. Hyponatremia has been associated with a worse outcome in several pathologic conditions The main objective of this study was to determine whether serum sodium alterations may be independent predictors of the outcome of hospitalized COVID-19 patients. Design and methods In this observational study, data from 441 laboratory-confirmed COVID-19 patients admitted to a University Hospital were collected. After excluding 61 patients (no serum sodium at admission available, saline solution infusion before sodium assessment, transfer from another hospital), data from 380 patients were analyzed. Results 274 (72.1%) patients had normonatremia at admission, 87 (22.9%) patients had hyponatremia and 19 (5%) patients had hypernatremia. We found an inverse correlation between serum sodium and IL-6, whereas a direct correlation between serum sodium and PaO2/FiO2 ratio was observed. Patients with hyponatremia had a higher prevalence of non-invasive ventilation and ICU transfer than those with normonatremia or hypernatremia. Hyponatremia was an independent predictor of in-hospital mortality (2.7-fold increase vs normonatremia) and each mEq/L of serum sodium reduction was associated with a 14.4% increased risk of death. Conclusions These results suggest that serum sodium at admission may be considered as an early prognostic marker of disease severity in hospitalized COVID-19 patients.
Published: 2021
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20. Airway events in obese vs. non‐obese elective surgical patients: a cross‐sectional observational study

Author: Michael Shaw, Pan-London Peri-operative Audit, Ken Ting, James Waiting, Lauren Barraclough, John Jeans, and B Black
Subjects: Adult, Male, Risk, medicine.medical_specialty, Bariatrics, Adolescent, medicine.medical_treatment, Population, Bariatric Surgery, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, law, Intubation, Intratracheal, Humans, Medicine, Obesity, 030212 general & internal medicine, Airway Management, education, Aged, Aged, 80 and over, education.field_of_study, business.industry, Incidence (epidemiology), Tracheal intubation, Middle Aged, respiratory system, medicine.disease, Comorbidity, Intensive care unit, respiratory tract diseases, Cross-Sectional Studies, Anesthesiology and Pain Medicine, Oxygen Saturation, Anesthesia, Population study, Female, business, Airway
Abstract: Obesity is an increasingly prevalent comorbidity within the UK population. The aim of this study was to determine the proportion of obese patients in an elective surgical population. The second aim was to determine the choice of airway equipment and incidence of airway events in obese vs. non-obese patients. We conducted a cross-sectional observational study over two 24-h periods in March 2018 across 39 hospitals in the greater London area. Data were collected regarding 1874 patients. The incidence of obesity was 32% in the study population compared with 26% in the general UK population (p < 0.0001). Minor airway events were defined as: desaturation to Sp O2 < 90%; failed mask ventilation; supraglottic airway device problem; aspiration; airway trauma and difficult intubation; or recognised oesophageal intubation. Major airway events were defined as: unrecognised oesophageal intubation; a 'cannot intubate cannot oxygenate' emergency; the need for unplanned front-of-neck airway; cardiac arrest; or unplanned intensive care unit admission due to an airway event. In total, 89 minor and two major airway events were recorded. Obese patients were more likely to experience a minor airway event (RR 2.39, 95%CI 1.60-3.57), the most common being desaturation (Sp O2 < 90%). The use of a supraglottic airway device in obese vs. non-obese patients was associated with increased airway events (RR 3.46 [1.88-6.40]). Tracheal intubation vs. supraglottic airway device use increased with obesity class but was not associated with a decrease in airway events (RR 0.90 [0.53-1.55]). Our data suggest that obesity is more common in the elective surgical vs. general population and minor airway events are more common in obese vs. non-obese elective patients.
Published: 2021
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21. Case studies on the usability, acceptability and functionality of autonomous mobile delivery robots in real-world healthcare settings

Author: Norina Gasteiger, Ngaire Kerse, Eve Topou, Bruce A. MacDonald, Mikaela Law, Ho Seok Ahn, Kathy Peri, and Elizabeth Broadbent
Subjects: 0209 industrial biotechnology, Process management, Robot, Computer science, Computational Mechanics, 02 engineering and technology, 01 natural sciences, Staff Workload, 020901 industrial engineering & automation, Artificial Intelligence, Residential care, Health care, Pathology laboratory, Engineering (miscellaneous), business.industry, Mechanical Engineering, 010401 analytical chemistry, technology, industry, and agriculture, Usability, GoCart, Workforce shortage, 0104 chemical sciences, body regions, Healthcare settings, Residential care facility, business, Delivery, human activities
Abstract: Autonomous mobile delivery robots are used as a way to improve efficiency in hospitals and reduce staff workload amongst a growing workforce shortage in healthcare. These two case studies investigated the usability, acceptability and functionality of two GoCart delivery robots at two different healthcare settings. The GoCart robots assisted with delivering blood and urine samples at a pathology laboratory and delivering meals at a residential care facility during a two-week period. A total of 50 participants (direct and secondary users, and managers) were interviewed about their experiences with the robot and answered questions about its design and functionality, safety and security, usability and their overall attitudes towards having the robot at their facility. Results showed that the participants from both sites thought the robots could be a good addition to their facilities to improve efficiency and reduce staff workload. The robot was received more positively at the residential care facility than the pathology laboratory. Improvements still need to be made to adapt the robots to each site before implementing the GoCarts long term, including changes to the size and screen. These case studies demonstrate that autonomous mobile delivery robots could be a useful addition to residential care facilities and pathology laboratory sites. Overall, this research adds to the current evidence showing potential uses for delivery robots and highlights important design considerations.
Published: 2021
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22. Endocrine-related adverse events in a large series of cancer patients treated with anti-PD1 therapy

Author: Isabella Ciardetti, Rossella Rubino, Lorenzo Antonuzzo, Andrea Marini, Mario Maggi, Giandomenico Roviello, Elena Margherita Presotto, Nicola Pimpinelli, Enrico Mini, Alessandro Peri, Lorenzo Livi, Marco Brugia, and Isacco Desideri
Subjects: Oncology, medicine.medical_specialty, Lung Neoplasms, Endocrinology, Diabetes and Metabolism, Thyroid Gland, 030209 endocrinology & metabolism, Pembrolizumab, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Antineoplastic Agents, Immunological, Internal medicine, Carcinoma, Non-Small-Cell Lung, Medicine, Endocrine system, Humans, Adverse effect, Cancer, Retrospective Studies, business.industry, Melanoma, Endocrine toxicity, Thyroid, medicine.disease, Anti PD-1, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Toxicity, Original Article, Female, Immunotherapy, Nivolumab, business
Abstract: Purpose Immune checkpoint inhibitors have opened a new scenario in the treatment of cancer. These agents can elicit adverse events, which may affect different systems and organs, including the endocrine system. The aims of this study were to evaluate the impact of the anti-PD-1 molecules nivolumab and pembrolizumab on endocrine toxicity and on patient outcome. Methods A retrospective and multicentre study was designed, which involved a total of 251 patients affected by different tumors (mostly non-small cell lung cancer, 68.92% and melanoma, 24.30%) and treated with the PD-1 inhibitors nivolumab (61.35%) or pembrolizumab (38.65%) for up to 60 months. Clinical and biochemical data were recorded until July 31, 2020. Results Endocrine toxicity occurred in 70 out of 251 patients (27.89%). It was mostly related to thyroid dysfunction and in 75% of cases occurred within 6 months from the beginning of therapy. A previous endocrine morbidity and female gender were predictors of endocrine toxicity. There was no association between endocrine dysfunction and patient outcome. However, when all toxicities (i.e., endocrine and non endocrine) were considered, a significant association with progression-free survival and overall survival was found. Conclusions Thyroid alterations are frequently observed in cancer patients treated with anti PD-1 drugs, particularly in women and in the presence of a previous endocrinopathy. We suggest that regular thyroid assessment should be performed in these patients, especially in the first months of therapy. Finally, the onset of side effects, related to anti PD-1 agents, appears to be associated with a better outcome.
Published: 2021

23. RANCANG BANGUN ALAT MONITORING DAYA DENGAN HMI BERBASIS ARDUINO UNO SEBAGAI OPC

Author: Resa Pramudita and Neris Peri Ardiansyah
Subjects: Maximum power principle, Control power, business.industry, Computer science, Voltage sensor, Electrical engineering, Current sensor, Electric power, Electricity, business, Line (electrical engineering), Power (physics)
Abstract: Listrik merupakan unsur yang tidak dapat dihilangkan dalam perkembangan teknologi. Setiap rumah memiliki daya maksimal yang dapat bekerja pada waktu yang sama. Jika pemakaian melebihi dari daya listrik, secara otomatis ACB akan memutuskan jalur secara keseluruhan. Pada kesempatan ini dikembangkan alat pengontrol daya menggunakan komputer dengan arduino sebagai OPC. Sensor-sensor yang digunakan di antaranya adalah sensor arus ACS712 dan tegangan ZMPT101B sebagai sensor untuk mengetahui daya pada beban. Alat ini bekerja secara otomatis yang dikendalikan dan dimonitor melalui komputer.
Published: 2021
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24. Megaprostheses and custom-made implants in complex cases of revision surgery after TKA

Author: Giacomo Peri, Stefano Giannotti, Andrea Facchini, Nicola Mondanelli, Nicolò Nuvoli, and Elisa Troiano
Subjects: 030222 orthopedics, medicine.medical_specialty, Osteosynthesis, Bone stock, business.industry, 030229 sport sciences, Knee Joint, Surgery, Resection, Proximal tibia, 03 medical and health sciences, 0302 clinical medicine, Orthopedic surgery, medicine, Implant, Complication, business
Abstract: The use of megaprostheses or custom-made devices is an established treatment for or- thopedic malignancies, but their indication has been expanded to some non-neoplastic conditions such as complex cases of re-revision surgery or failed osteosynthesis. A con- secutive series of 5 patients were treated with megaprostheses as a solution for complex cases of re-revision surgery around the knee joint. Each patient was assessed clinically and radiographically at 1, 3, 6, and 12 months after surgery. One patient died for intestinal infarc- tion after surgery. The 4 remaining patients resumed gait and knee function. We did not observe infections or mobilizations of the implants, and the only complication we described was patellar dislocation of the extensor mechanism when the implant with proximal tibia resection was used. Complex re-revision surgery after TKA represents a major challenge for the orthopedic surgeon due to poor bone stock and the presence of prosthetic revision components. The implant of megaprostheses or custom-made devices can play a crucial role in these rare but complex cases of non-oncological orthopedic surgery ensuring early functional recovery.
Published: 2021
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25. Trade policy uncertainty: Evidence from the Arab League countries

Author: Peri Silva and Atika Benaddi
Subjects: Commercial policy, business.industry, Geography, Planning and Development, Economics, International trade, Development, business, Arab league
Published: 2021
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26. Psychoanalysis and <scp>CBT</scp> : From Rivalry to Hospitality in Psychotherapy Integration

Author: Yael Peri Herzovich and Aner Govrin
Subjects: Psychiatry and Mental health, Clinical Psychology, Psychotherapist, Psychoanalysis, Hospitality, business.industry, business, Psychology, Rivalry
Published: 2021
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27. Energy Performance and Indoor Comfort of a 1930s Italian School Building: A case study

Author: Angela Alfano, Laura Cirrincione, Maria La Gennusa, Giorgia Peri, Gianluca Scaccianoce, Cirrincione L., la Gennusa M., Peri G., Scaccianoce G., and Alfano A.
Subjects: School, Building Simulation, business.industry, Energy Efficiency, Energy consumption, Environmental economics, Investment (macroeconomics), language.human_language, Occupational safety and health, Indoor Environmental Quality, Thermal Comfort, Order (exchange), Climate change scenario, language, Building Retrofit, business, Sicilian, Productivity, Tertiary sector of the economy
Abstract: Reducing energy consumption in the building tertiary sector, which accounts for a big share of the total energy use (and related CO 2 emissions) at European and Italian level, represent a strong element of safety for the EU-28. On the other hand, it is important to improve the, often overlooked, indoor comfort conditions of Italian schools since they have a significant impact on the well-being, productivity, health and safety of their occupants. Thus, it is appropriate to take into account the combination of both needs, also in light of the climate change scenario, in order to identify adequate improvement measures and justify such economic investment. This paper brings a contribution to the matter by means of a case study concerning a Sicilian school belonging to the 1930s period, representing an emblematic case of the Italian school construction panorama.
Published: 2021

28. Characterization of As-Grown and Regrown GaN-on-GaN Structures for Vertical p-n Power Devices

Author: Prudhvi Peri, Yuji Zhao, Kai Fu, Houqiang Fu, and David J. Smith
Subjects: 010302 applied physics, Materials science, business.industry, Doping, Gallium nitride, 02 engineering and technology, Chemical vapor deposition, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, chemistry, Transmission electron microscopy, Etching (microfabrication), 0103 physical sciences, Materials Chemistry, Optoelectronics, Power semiconductor device, Metalorganic vapour phase epitaxy, Dry etching, Electrical and Electronic Engineering, 0210 nano-technology, business
Abstract: This work has investigated the effects of etching treatment on as-grown and regrown GaN-on-GaN structures intended for vertical p-n power device applications. Surfaces of thick unintentionally doped (UID) GaN layers, grown homoepitaxially via metal-organic chemical vapor deposition on freestanding GaN bulk substrates, were subjected to RF-plasma dry etching, and additional layers of UID-GaN/p-GaN were then grown. The as-grown and regrown structures were examined in cross section using transmission electron microscopy. Two different types of etching treatment were used, fast-etch-only and multiple etches with decreasing power. Images of the fast-etch-only devices clearly showed the GaN-on-GaN interface at the etched location, and low device breakdown voltages were measured (reverse bias in the range of 45–95V). In comparison, no interfaces were visible in devices after multiple etching steps, and the corresponding device breakdown voltages were markedly higher (reverse bias ~1200–1270V). These results emphasize the importance of optimizing surface etching techniques for avoiding degraded performance in GaN-on-GaN power devices that require GaN regrowth.
Published: 2021
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29. Minimally invasive distal pancreatectomy: a case-matched cost-analysis between robot-assisted surgery and direct manual laparoscopy

Author: Franca Melfi, Giulio Di Candio, Desirée Gianardi, Luca Pollina, Gregorio Di Franco, Andrea Peri, Matteo Bianchini, Andrea Pietrabissa, Simone Guadagni, Carlo Milli, Luca Morelli, Giuseppe Turchetti, Matteo Palmeri, Niccolò Furbetta, Valentina Lorenzoni, and Domenica Mamone
Subjects: medicine.medical_specialty, Multivariate analysis, Operative Time, 030230 surgery, Article, Variable cost, Laparoscopic distal pancreatectomy, 03 medical and health sciences, Pancreatectomy, Postoperative Complications, 0302 clinical medicine, Robotic Surgical Procedures, medicine, Humans, Laparoscopy, Fixed cost, Retrospective Studies, medicine.diagnostic_test, business.industry, Costs’ analysis, Robotic distal pancreatectomy, Length of Stay, Surgery, Pancreatic Neoplasms, Treatment Outcome, 030220 oncology & carcinogenesis, Costs and Cost Analysis, Cost analysis, Operative time, Distal pancreatectomy, business, Abdominal surgery
Abstract: Background Few studies have reported a structured cost analysis of robotic distal pancreatectomy (RDP), and none have compared the relative costs between the robotic-assisted surgery (RAS) and the direct manual laparoscopy (DML) in this setting. The aim of the present study is to address this issue by comparing surgical outcomes and costs of RDP and laparoscopic distal pancreatectomies (LDP). Methods Eighty-eight RDP and 47 LDP performed between January 2008 and January 2020 were retrospectively analyzed. Three comparable groups of 35 patients each (Si-RDP-group, Xi-RDP group, LDP-group) were obtained matching 1:1 the RDP-groups with the LDP-group. Overall costs, including overall variable costs (OVC) and fixed costs were compared using generalized linear regression model adjusting for covariates. Results The conversion rate was significantly lower in the Si-RDP-group and Xi-RDP-group: 2.9% and 0%, respectively, versus 14.3% in the LDP-group (p = 0.045). Although not statistically significant, the mean operative time was lower in Xi-RDP-group: 226 min versus 262 min for Si-RDP-group and 247 min for LDP-group. The overall post-operative complications rate and the length of hospital stay (LOS) were not significantly different between the three groups. In LDP-group, the LOS of converted cases was significantly longer: 15.6 versus 9.8 days (p = 0.039). Overall costs of LDP-group were significantly lower than RDP-groups, (p p = 0.099), and between LDP-group and the RDP-groups when the spleen preservation was indicated (p = 0.115 and p = 0.261 for Si-RDP-group and Xi-RDP-group, respectively). Conclusions RAS is more expensive than DML for DP because of higher acquisition and maintenance costs. The flattening of these differences considering only the variable costs, in a high-volume multidisciplinary center for RAS, suggests a possible optimization of the costs in this setting. RAS might be particularly indicated for minimally invasive DP when the spleen preservation is scheduled.
Published: 2021
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30. CISMET

Author: Mara Nikolaidou, Dimosthenis Anagnostopoulos, Md. Mahmudul Hasan, George Kousiouris, Peri Loucopoulos, and Teta Stamati
Subjects: Class (computer programming), Process management, Relation (database), Computer Networks and Communications, business.industry, Process (engineering), Computer science, Ontology (information science), Software, General Data Protection Regulation, Information system, media_common.cataloged_instance, European union, business, Information Systems, media_common
Abstract: Compliance to regulatory requirements is a critical concern in information system development projects. Managing this aspect is increasingly challenging while failures impose costly consequence on the organizations world-wide. However, how a legislation may or may not affect information system development projects is often not easily identifiable due to lack of clear understanding and guidelines. This paper presents compliant information system development (CISMET) ontology, exploiting concepts from 21 existing ontologies (regarding regulatory compliance and information system development). The key findings are the six parent classes in the CISMET ontology describing the system development goals, services, process, activities, artifacts, and resources. Also, there are 26 sub classes and 21 class properties that describe various concepts and their relationships in regulatory compliant information system development. The General Data Protection Regulation (GDPR) of the European Union has been instantiated in the proposed framework to indicate how regulatory requirements compliance concepts are mapped to system development projects. Thus, involved stakeholders (information system researchers and system developers) may identify dependencies and actions needed with relation to various rules in the regulation and their link to the system elements through a relevant software application. The latter enables users to easily submit queries towards the backend ontology through a specialized front-end application that can aid in formulating and submitting these queries.
Published: 2021
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31. PELATIHAN MANAJEMEN BENGKEL/LABORATORIUM BAGI GURU MATA PELAJARAN PRAKTIK DI SMK WILAYAH KABUPATEN PANDEGLANG

Author: Iik Nurulpaik, H Hasbullah, Wawan Purmana, and Neris Peri Ardiansyah
Subjects: Medical education, Engineering, Laboratory management, business.industry, media_common.quotation_subject, Vocational education, Practicum, Quality (business), Subject (documents), business, Competence (human resources), media_common
Abstract: Manajemen bengkel/laboratorium di Sekolah Menengah Kejuruan secara fungsinya belum dimanfaatkan secara maksimal, hanya terpaku sebatas penggunaan tempat praktikum siswa dan belum banyak dimanfaatkan oleh para pengelola dalam meningkatkan kulitas bengkel/laboratorium di sekolah. Manajemen fasilitas bengkel/laboratorium sangat penting dalam peningkatan kulitas guru dan siswa dalam memenuhi mutu pembelajaran dan hasil dari kulitas pembelajaran guna meningkatkan kualitas lulusan. Sekolah Menengah Kejuruan pada dasarnya tidak hanya diperuntukkan untuk memahami penguasaan teori saja, namun harus juga memiliki kompetensi teori dan praktik dalam memenuhi kriteria unjuk kerja. Dengan demikian guru memiliki peranan sangat penting dalam penguasaan dan pengeloaan bengkel. Pelatihan Manajemen Bengkel/Laboratorium Bagi Guru Mata Pelajaran Praktik di SMK Wilayah Kabupaten Pandeglang dilakukan untuk meningkatkan manajemen guru dalam melakukan pengelolaan fasilitas bengkel/laboratorium di SMK.
Published: 2021
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32. Temporal Dynamics of Workplace Acoustic Scenes: Egocentric Analysis and Prediction

Author: Shrikanth S. Narayanan, Karel Mundnich, Tiantian Feng, Arindam Jati, Amrutha Nadarajan, Benjamin Girault, and Raghuveer Peri
Subjects: Audio signal, Acoustics and Ultrasonics, Artificial neural network, Computer science, business.industry, Speech recognition, Deep learning, Perspective (graphical), Sound recording and reproduction, Computational Mathematics, Identification (information), Recurrent neural network, Computer Science (miscellaneous), Artificial intelligence, Electrical and Electronic Engineering, business, Association (psychology)
Abstract: Identification of the acoustic environment from an audio recording, also known as acoustic scene classification, is an active area of research. In this paper, we study dynamically-changing background acoustic scenes from the egocentric perspective of an individual in a workplace. In a novel data collection setup, wearable sensors were deployed on individuals to collect audio signals within a built environment, while Bluetooth-based hubs continuously tracked the individual's location which represents the acoustic scene at a certain time. The data of this paper come from 170 hospital workers gathered continuously during work shifts for a 10 week period. In the first part of our study, we investigate temporal patterns in the egocentric sequence of acoustic scenes encountered by an employee, and the association of those patterns with factors such as job-role and daily routine of the individual. Motivated by evidence of multifaceted effects of ambient sounds on human psychology, we also analyze the association of the temporal dynamics of the perceived acoustic scenes with particular behavioral traits of the individual. Experiments reveal rich temporal patterns in the acoustic scenes experienced by the individuals during their work shifts, and a strong association of those patterns with various constructs related to job-roles and behavior of the employees. In the second part of our study, we employ deep learning models to predict the temporal sequence of acoustic scenes from the egocentric audio signal. We propose a two-stage framework where a recurrent neural network is trained on top of the latent acoustic representations learned by a segment-level neural network. The experimental results show the efficacy of the proposed system in predicting sequence of acoustic scenes, highlighting the existence of underlying temporal patterns in the acoustic scenes experienced in workplace.
Published: 2021
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33. Physical Activity After Treatment for Symptomatic Peripheral Artery Disease

Author: Jeremy Provance, Kim G. Smolderen, Vittal Hijjaji, John A. Spertus, Ali O. Malik, Elizabeth A. Jackson, Kensey Gosch, Poghni A. Peri-Okonny, Mehdi H. Shishehbor, Carlos Mena-Hurtado, and Sarthak Patel
Subjects: Male, Work, medicine.medical_specialty, Arterial disease, Health Status, Social Interaction, Physical activity, Disease, 030204 cardiovascular system & hematology, Conservative Treatment, Article, Peripheral Arterial Disease, 03 medical and health sciences, Leisure Activities, 0302 clinical medicine, Internal medicine, medicine, Humans, Ankle Brachial Index, In patient, 030212 general & internal medicine, Endovascular treatment, Exercise, Aged, business.industry, Endovascular Procedures, Intermittent Claudication, Middle Aged, Physical activity level, Exercise Therapy, Logistic Models, Patient Satisfaction, Multivariate Analysis, Linear Models, Quality of Life, Cardiology, Female, Smoking Cessation, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Sedentary Behavior, medicine.symptom, Cardiology and Cardiovascular Medicine, Claudication, business, Vascular Surgical Procedures, Platelet Aggregation Inhibitors, After treatment
Abstract: The association of invasive versus noninvasive treatment and physical activity level in patients with claudication remains unclear. Participants with claudication were enrolled from US vascular clinics. Treatment was categorized as invasive (surgical or endovascular treatment3 months of initial visit) versus noninvasive. Self-reported leisure time (LTPA) and work related physical activity (WRPA) (sedentary, mild, moderate/strenuous), and health status (peripheral artery questionnaire summary score [PAQ SS]) was measured at baseline and 12 months. Change in PA was also categorized as increased, decreased, persistent sedentary [reference] and persistent active based on activity status at baseline and 12 months. Multivariable logistic regression assessed the association of treatment with 12-month LTPA and WRPA. Multivariable linear regression examined the association between 12-month change in PA with a 12-month change in PAQ. A total of 196of 656 patients (29.9%) underwent invasive treatment. There was no association between treatment and 12-month LTPA (p = 0.77) or WRPA (p = 0.26). Compared with being persistently sedentary, increased LTPA was associated with increased PAQ SS (OR 11.1 95% CI [4.4 to 17.7], p0.01). In conclusion, there was no association between invasive treatment and physical activity at follow up despite a greater health status change in the invasive group. As increased physical activity was associated with more health status gains than remaining sedentary, additional ways to improve physical activity levels could potentially improve PAD outcomes.
Published: 2021
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34. APPLICATION OF APPROPRIATE TECHNOLOGY IN HOUSEHOLD WASTE TREATMENT IN SUKAJAYA VILLAGE, WEST BANDUNG REGENCY

Author: Wasimudin Surya Saputra, Elih Mulyana, Neris Peri Ardiansyah, and I Wayan Ratnata
Subjects: Household waste, Waste management, business.industry, Compost, media_common.quotation_subject, Community service, Biodegradable waste, engineering.material, Appropriate technology, engineering, Added value, Quality (business), Human resources, business, media_common
Abstract: This paper aims to describe the educational process of household waste management training by applying appropriate technology as part of human resources development in processing household waste. The participation of housewives and non-governmental organizations in this activity is part of increasing sensitivity to the environment to overcome the problem of household waste. The application of appropriate technology in processing household waste is a major part of the PKM (Community Service) activities of the Assisted Village, the technology of organic and inorganic waste chopping machines is used to produce semi-finished materials for compost and paving blocks, at that stage the technology is appropriate to provide added value in the process household waste treatment. The utilization of organic waste powder that is processed with EM4 produces solid compost, and inorganic waste can be processed as a base material for paving blocks. The results of the PKM in the Assisted Village have added value both in improving the quality of environmental cleanliness and increasing employment for the surrounding community in utilizing appropriate technology as a household waste processor.
Published: 2021
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35. Pediatric Patients’ and Parents’ Perspectives of Unsedated Transnasal Endoscopy in Eosinophilic Esophagitis: A Qualitative Descriptive Study

Author: Joel A. Friedlander, Dena Schulman-Green, Corey Scherer, Peri Sosensky, Alex Koral, Clinton Smith, and Meredith Levy
Subjects: Parents, medicine.medical_specialty, Sedation, MEDLINE, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, medicine, Humans, Transnasal endoscopy, Endoscopy, Digestive System, Child, Eosinophilic esophagitis, medicine.diagnostic_test, business.industry, Esophagogastroduodenoscopy, Qualitative descriptive, Gastroenterology, Endoscopy, Eosinophilic Esophagitis, medicine.disease, Intravenous anesthesia, Pediatrics, Perinatology and Child Health, Physical therapy, 030211 gastroenterology & hepatology, medicine.symptom, business, Qualitative research
Abstract: Background Eosinophilic esophagitis is an increasingly common inflammatory disease of the esophagus. Diagnosis and management are based on the histological presence of eosinophils in the esophageal mucosa, often requiring multiple endoscopies with sedation. Unsedated transnasal endoscopy (TNE), an alternative method of assessing the mucosa without the risks of sedation, is now being performed in the pediatric population. This is the first qualitative study on pediatric patients' and parents' experiences with TNE. Objective The objective of the study was to describe pediatric patients' and parents' experiences of TNE with the goal of refining TNE protocols to improve the clinical experience. Methods We used a qualitative descriptive approach that included in-depth, semistructured interviews with patients and parents following completion of TNE. Interviews continued until we reached thematic saturation. We analyzed data using qualitative content analysis. Results A total of 21 interviews were completed. We identified 4 themes: Appeal of TNE; Expectations and Preparation for TNE; Tolerance of TNE; and Evaluation of TNE. Perceived positive aspects of TNE were no exposure to intravenous anesthesia; helpful and clear preparation for the procedure with a demonstration video and physician phone call; distraction during TNE with virtual reality goggles and a stress ball; parent able to accompany the patient; and TNE requiring less time than an esophagogastroduodenoscopy. Negative aspects included patient stress before TNE, patient dislike of nasal spray taste and sensation, and discomfort during the TNE procedure. Conclusion The overall perception of TNE among our participants was positive. Study data will allow pediatric gastroenterologists the opportunity to improve both preparation for and comfort during TNE.
Published: 2020
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36. Psychosocial risk factors for impaired health-related quality of life in living kidney donors: results from the ELIPSY prospective study

Author: Christina Papachristou, Inês C. Frade, L. Yucetin, Ignacio Revuelta, Ingela Fehrman-Ekholm, Martí Manyalich, Entela Kondi, Xavier Torres, Niclas Kvarnström, Ana Menjivar, Alice Lopes, Erika De Sousa-Amorim, Federico Oppenheimer, Leonídio Dias, David Paredes, Josep M. Peri, Chloë Ballesté, Christian Hiesse, and Fritz Diekmann
Subjects: Gerontology, Adult, Male, Risk factors in diseases, media_common.quotation_subject, Science, Population, 030232 urology & nephrology, 030230 surgery, Article, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Medical research, Risk Factors, Organ donors, Living Donors, Personality, Medicine, Psychology, Cluster Analysis, Humans, Prospective Studies, Prospective cohort study, education, media_common, education.field_of_study, Multidisciplinary, business.industry, Factors de risc en les malalties, Middle Aged, Mental health, Kidney Transplantation, Logistic Models, Social Class, Nephrology, Donation, Quality of Life, Female, Risk assessment, business, Donants d'òrgans, Psychosocial
Abstract: Living kidney donors’ follow-up is usually focused on the assessment of the surgical and medical outcomes. Whilst the psychosocial follow-up is advocated in literature. It is still not entirely clear which exact psychosocial factors are related to a poor psychosocial outcome of donors. The aim of our study is to prospectively assess the donors’ psychosocial risks factors to impaired health-related quality of life at 1-year post-donation and link their psychosocial profile before donation with their respective outcomes. The influence of the recipient’s medical outcomes on their donor’s psychosocial outcome was also examined. Sixty donors completed a battery of standardized psychometric instruments (quality of life, mental health, coping strategies, personality, socio-economic status), and ad hoc items regarding the donation process (e.g., motivations for donation, decision-making, risk assessment, and donor-recipient relationship). Donors’ 1-year psychosocial follow-up was favorable and comparable with the general population. So far, cluster-analysis identified a subgroup of donors (28%) with a post-donation reduction of their health-related quality of life. This subgroup expressed comparatively to the rest, the need for more pre-donation information regarding surgery risks, and elevated fear of losing the recipient and commitment to stop their suffering.
Published: 2020

37. Technique Description and Outcomes of Robotic Transvaginal-Assisted Living Donor Kidney Transplantation

Author: Lluís Peri Cusi, Tarek Ajami Fardoun, Antonio Alcaraz Asensio, and Mireia Musquera Felip
Subjects: Adult, medicine.medical_specialty, Urology, Diuresis, Postoperative Complications, Robotic Surgical Procedures, Living Donors, medicine, Humans, Robotic surgery, Prospective Studies, Kidney transplantation, Assisted living, Kidney, business.industry, Middle Aged, medicine.disease, Kidney Transplantation, Surgery, Transplantation, Treatment Outcome, medicine.anatomical_structure, Vagina, Operative time, Female, business, Donor kidney
Abstract: Objective: The aim of the study was to describe the surgical technique of totally robotic kidney transplantation with transvaginal insertion and to assess its safety and feasibility. Methods: It is a prospective analysis of the first 5 cases of robotic kidney transplantation with transvaginal insertion. Robotic-assisted kidney transplantation was performed after transvaginal insertion of a living donor kidney graft. Donor’s and recipient’s characteristics, intraoperative variables, postoperative complications, and surgical outcomes were assessed. Results: The median operative time was 220 min. Mean rewarming ischemia time of 53 min, with immediate diuresis. No intraoperative complications were observed. Mean hospitalization period was 9 days, with mean Cr of 1.5 mg/dL at discharge. Conclusions: Robotic kidney transplantation with transvaginal insertion is feasible and safe. A greater number of procedures are required to confirm the results of this new technique.
Published: 2020
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38. Hand-assisted laparoscopic approach for the treatment of gastrosplenic fistula: A case report and review of the literature

Author: Andrea Peri, F. S. Latteri, Luigi Pugliese, and Virginia Gallo
Subjects: medicine.medical_specialty, Gastrosplenic fistula, business.industry, Fistula, lcsh:Surgery, Hand-assisted laparoscopy, Diffuse large B-cell lymphoma, lcsh:RD1-811, medicine.disease, Laparoscopic splenectomy, Lymphoma, Surgery, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, hemic and lymphatic diseases, medicine, Splenectomy, Hand assisted, 030211 gastroenterology & hepatology, Complication, Splenic Lymphoma, business, Laparoscopic treatment, Wedge resection (lung)
Abstract: Gastrosplenic fistula is a rare complication of gastric or splenic lymphoma. Here we report the case of a 48 years old man who developed a gastrosplenic fistula secondary to splenic diffuse large B-cell lymphoma, successfully managed with hand-assisted laparoscopic splenectomy and gastric wedge resection. A review of the available literature is also presented, 33 cases of gastrosplenic fistula associated to gastric or splenic lymphoma were found, of which 25 were treated surgically. This case represents the first report of laparoscopic treatment of lymphoma-related gastrosplenic fistula described to our knowledge in the available literature.
Published: 2020

39. Overlap and Mutual Distinctions Between Clinical Recovery and Personal Recovery in People With Schizophrenia in a One-Year Study

Author: Dubreucq, Julien, Gabayet, Franck, Godin, Ophélia, Andre, Myrtille, Aouizerate, Bruno, Capdevielle, Delphine, Chereau, Isabelle, Clauss-Kobayashi, Julie, Coulon, Nathalie, D’amato, Thierry, Dorey, Jean-Michel, Dubertret, Caroline, Faraldo, Mégane, Laouamri, Hakim, Leigner, Sylvain, Lancon, Christophe, Leboyer, Marion, Llorca, Pierre-Michel, Mallet, Jasmina, Misdrahi, David, Passerieux, Christine, Rey, Romain, Pignon, Baptiste, Schorr, Benoit, Urbach, Mathieu, Schürhoff, Franck, Szoke, Andrei, Berna, Fabrice, Haffen, E, Barteau, V, Bensalem, S, Souryis, K, Petrucci, J, Wahiche, G, Bourguignon, E, Deloge, A, Vilà, E, Blanc, O, Denizot, H, Honciuc, R, Lacelle, D, Pires, S, Portalier, C, Leignier, S, Roman, C, Chesnoy-Servanin, G, Vehier, A, Faget, C, Metairie, E, Peri, P, Vaillant, F, Boyer, L, Fond, Guillaume, Vidailhet, P, Zinetti-Bertschy, A, Michel, T, Garbisson, A, Belmonte, C, Dubois, T, Esselin, S, Jarroir, M, Fondation FondaMental [Créteil], Centre Hospitalier Alpes Isère, IMRB - 'Biologie du système neuromusculaire' [Créteil] (U955 Inserm - UPEC), École nationale vétérinaire - Alfort (ENVA)-Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Hôpital Charles Perrens, Nutrition et Neurobiologie intégrée (NutriNeuro), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Clermont Auvergne (UCA), Les Hôpitaux Universitaires de Strasbourg (HUS), Neuropsychologie Cognitive et Physiopathologie de la Schizophrénie (NCPS), Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg, Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier le Vinatier [Bron], Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de psychiatrie et neurosciences de Paris (IPNP - U1266 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), Pôle de psychiatrie et d'addictologie des Hôpitaux Universitaires Henri-Mondor [Créteil], Centre hospitalier universitaire Henri-Mondor [Créteil], Centre Hospitalier de Versailles André Mignot (CHV), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Civil de Strasbourg-Université de Strasbourg (UNISTRA), Centre de recherche en neurosciences de Lyon (CRNL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre hospitalier Charles Perrens [Bordeaux], Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)
Subjects: Adult, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Meaningful life, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Full recovery, personal recovery, Medicine, Humans, psychosocial treatment, 030212 general & internal medicine, full recovery, Depression (differential diagnoses), Analysis of Variance, Chi-Square Distribution, business.industry, Perspective (graphical), Recovery of Function, Mental illness, medicine.disease, clinical recovery, 030227 psychiatry, schizophrenia, Psychiatry and Mental health, Schizophrenia, Quality of Life, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], business, Psychosocial, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Regular Articles
Abstract: Recovery is a multidimensional construct that can be defined either from a clinical perspective or from a consumer-focused one, as a self-broadening process aimed at living a meaningful life beyond mental illness. We aimed to longitudinally examine the overlap and mutual distinctions between clinical and personal recovery. Of 1239 people with schizophrenia consecutively recruited from the FondaMental Advanced Centers of Expertise for SZ network, the 507 present at one-year did not differ from those lost to follow-up. Clinical recovery was defined as the combination of clinical remission and functional remission. Personal recovery was defined as being in the rebuilding or in the growth stage of the Stages of Recovery Instrument (STORI). Full recovery was defined as the combination of clinical recovery and personal recovery. First, we examined the factors at baseline associated with each aspect of recovery. Then, we conducted multivariable models on the correlates of stable clinical recovery, stable personal recovery, and stable full recovery after one year. At baseline, clinical recovery and personal recovery were characterized by distinct patterns of outcome (i.e. better objective outcomes but no difference in subjective outcomes for clinical recovery, the opposite pattern for personal recovery, and better overall outcomes for full recovery). We found that clinical recovery and personal recovery predicted each other over time (baseline personal recovery for stable clinical recovery at one year; P = .026, OR = 4.94 [1.30–23.0]; baseline clinical recovery for stable personal recovery at one year; P = .016, OR = 3.64 [1.31–11.2]). In short, given the interaction but also the degree of difference between clinical recovery and personal recovery, psychosocial treatment should target, beyond clinical recovery, subjective aspects such as personal recovery and depression to reach full recovery.
Published: 2022
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40. Simulation and Test of UAV Tasks With Resource-Constrained Hardware in the Loop

Author: Daniele Peri, A. Augello, Giuseppe Lo Re, Salvatore Gaglio, Augello A., Gaglio S., Lo Re G., and Peri D.
Subjects: System Testing, business.industry, Computer science, UAV, Computation, Real-time computing, Resource constrained, sync, Hardware-in-the-loop simulation, System testing, Test (assessment), Software, Hybrid Simulation, Embedded System, Hardware in the loop, business, Search and rescue
Abstract: Simulations are indispensable to reduce costs and risks when developing and testing algorithms for unmanned aerial vehicles (UAV) especially for applications in high risk scenarios like search and rescue (SAR) operations and post-disaster damage assessment. Many UAV applications require real-time tasks for which the timeliness of computations is fundamental. However, standard simulation tools are not guaranteed to run in sync with real-time events, leading to unreliable assessments of the ability of the target hardware to perform specific tasks. In this work we present a simulation and test system able to run UAV tasks on resource-constrained target hardware possibly adopted in these applications. The system allows for hardware-in-the-loop simulations in which a virtual UAV provided with virtual sensors is controlled by the software under test (SUT) running on the target hardware, while simulated and real time are kept in sync. We provide experimental results from the execution of several increasingly difficult tasks in the system.
Published: 2021
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41. Performance of the upgraded PreProcessor of the ATLAS Level-1 Calorimeter Trigger

Author: Aad, G., Abbott, B., Abbott, D. C., Abed Abud, A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adam, L., Adam Bourdarios, C., Adamczyk, L., Adamek, L., Adelman, J., Adersberger, M., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Akesson, T. P. A., Akilli, E., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Allaire, C., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Alunno Camelia, E., Alvarez Estevez, M., Alviggi, M. G., Amaral Coutinho, Y., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., An, F., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Andrei, V., Anelli, C. R., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Aparo, M. A., Aperio Bella, L., Aranzabal Barrio, N., Araujo Ferraz, V., Araujo Pereira, R., Arcangeletti, C., Arce, A. T. H., Arduh, F. A., Arguin, J. -F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Arrubarrena Tame, Z. P., Artoni, G., Asada, H., Asai, K., Asai, S., Asawatavonvanich, T., Asbah, N., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Augsten, K., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Bachacou, H., Bachas, K., Backman, F., Bagnaia, P., Bahmani, M., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Bakshi Gupta, D., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Banerjee, Sw., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barillari, T., Barisits, M. -S., Barkeloo, J., Barklow, T., Barnea, R., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimaraes da Costa, J., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bassalat, A., Basso, M. J., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. S., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. C., Beck, H. P., Becker, K., Becot, C., Beddall, A., Beddall, A. J., Bednyakov, V. A., Bedognetti, M., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beisiegel, F., Belfkir, M., Bell, A. S., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Benekos, N., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bessidskaia Bylund, O., Besson, N., Bethani, A., Bethke, S., Betti, A., Bevan, A. J., Beyer, J., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birch-Sykes, C. J., Birman, M., Bisanz, T., Biswal, J. P., Biswas, D., Bitadze, A., Bittrich, C., Bjorke, K., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Boerner, D., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bolz, A. E., Bomben, M., Bona, M., Bonilla, J. S., Boonekamp, M., Booth, C. D., Borbely, A. G., Borecka-Bielska, H. M., Borgna, L. S., Borisov, A., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Bossio Sola, J. D., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Breaden Madden, W. D., Brendlinger, K., Brener, R., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I., Brock, R., Brooijmans, G., Brooks, W. K., Brost, E., Bruckman de Renstrom, P. A., Bruers, B., Bruncko, D., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Bugge, M. K., Buhrer, F., Bulekov, O., Bullard, B. A., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burr, J. T. P., Burton, C. D., Burzynski, J. C., Buscher, V., Buschmann, E., Bussey, P. J., Butler, J. M., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Buxo Vazquez, C. J., Buzatu, A., Buzykaev, A. R., Cabras, G., Cabrera Urban, S., Caforio, D., Cai, H., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Caltabiano, A., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Camacho Toro, R., Camarda, S., Camarero Munoz, D., Camarri, P., Camerlingo, M. T., Cameron, D., Camincher, C., Campana, S., Campanelli, M., Camplani, A., Canale, V., Canesse, A., Cano Bret, M., Cantero, J., Cao, T., Cao, Y., Capeans Garrido, M. D. M., Capua, M., Cardarelli, R., Cardillo, F., Carducci, G., Carli, I., Carli, T., Carlino, G., Carlson, B. T., Carlson, E. M., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carra, S., Carratta, G., Carter, J. W. S., Carter, T. M., Casado, M. P., Casha, A. F., Castiglia, E. G., Castillo, F. L., Castillo Garcia, L., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Cavaliere, V., Cavasinni, V., Celebi, E., Celli, F., Cerny, K., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chadi, Z., Chakraborty, D., Chan, J., Chan, W. S., Chan, W. Y., Chapman, J. D., Chargeishvili, B., Charlton, D. G., Charman, T. P., Chatterjee, M., Chau, C. C., Che, S., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chen, B., Chen, C., Chen, C. H., Chen, H., Chen, J., Chen, S., Chen, S. J., Chen, X., Chen, Y., Chen, Y. -H., Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Cheu, E., Cheung, K., Chevalerias, T. J. A., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, I., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chow, Y. S., Christopher, L. D., Chu, M. C., Chu, X., Chudoba, J., Chwastowski, J. J., Chytka, L., Cieri, D., Ciesla, K. M., Cindro, V., Cioara, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubotaru, D. A., Ciungu, B. M., Clark, A., Clark, M. R., Clark, P. J., Clawson, S. E., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Coelho Lopes De Sa, R., Cohen, H., Coimbra, A. E. C., Cole, B., Colijn, A. P., Collot, J., Conde Muino, P., Connell, S. H., Connelly, I. A., Constantinescu, S., Conventi, F., Cooper-Sarkar, A. M., Cormier, F., Cormier, K. J. R., Corpe, L. D., Corradi, M., Corrigan, E. E., Corriveau, F., Costa, M. J., Costanza, F., Costanzo, D., Cowan, G., Cowley, J. W., Crane, J., Cranmer, K., Creager, R. A., Crepe-Renaudin, S., Crescioli, F., Cristinziani, M., Croft, V., Crosetti, G., Cueto, A., Cuhadar Donszelmann, T., Cui, H., Cukierman, A. R., Cunningham, W. R., Czekierda, S., Czodrowski, P., Czurylo, M. M., da Cunha Sargedas De Sousa, M. J., da Fonseca Pinto, J. V., da Via, C., Dabrowski, W., Dachs, F., Dado, T., Dahbi, S., Dai, T., Dallapiccola, C., Dam, M., D'Amen, G., D'Amico, V., Damp, J., Dandoy, J. R., Daneri, M. F., Danninger, M., Dao, V., Darbo, G., Dartsi, O., Dattagupta, A., Daubney, T., D'Auria, S., David, C., Davidek, T., Davis, D. R., Dawson, I., De, K., de Asmundis, R., de Beurs, M., de Castro, S., de Groot, N., de Jong, P., de la Torre, H., de Maria, A., de Pedis, D., de Salvo, A., de Sanctis, U., de Santis, M., de Santo, A., de Vivie De Regie, J. B., Dedovich, D. V., Deiana, A. M., Del Peso, J., Delabat Diaz, Y., Delgove, D., Deliot, F., Delitzsch, C. M., della Pietra, M., della Volpe, D., Dell'Acqua, A., Dell'Asta, L., Delmastro, M., Delporte, C., Delsart, P. A., Demarco, D. A., Demers, S., Demichev, M., Demontigny, G., Denisov, S. P., D'Eramo, L., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Dette, K., Deutsch, C., Devesa, M. R., Deviveiros, P. O., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Clemente, W. K., Di Donato, C., Di Girolamo, A., Di Gregorio, G., Di Micco, B., Di Nardo, R., Di Petrillo, K. F., Di Sipio, R., Diaconu, C., Dias, F. A., Dias Do Vale, T., Diaz, M. A., Diaz Capriles, F. G., Dickinson, J., Didenko, M., Diehl, E. B., Dietrich, J., Diez Cornell, S., Diez Pardos, C., Dimitrievska, A., Ding, W., Dingfelder, J., Dittmeier, S. J., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., Do Vale, M. A. B., Dobre, M., Dodsworth, D., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Dong, B., Donini, J., D'Onofrio, A., D'Onofrio, M., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dreyer, E., Dreyer, T., Drobac, A. S., Du, D., du Pree, T. A., Duan, Y., Dubinin, F., Dubovsky, M., Dubreuil, A., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Dudder, A. C., Duffield, E. M., D'Uffizi, M., Duflot, L., Duhrssen, M., Dulsen, C., Dumancic, M., Dumitriu, A. E., Dunford, M., Duperrin, A., Duran Yildiz, H., Duren, M., Durglishvili, A., Duschinger, D., Dutta, B., Duvnjak, D., Dyckes, G. I., Dyndal, M., Dysch, S., Dziedzic, B. S., Eggleston, M. G., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Jarrari, H., Ellajosyula, V., Ellert, M., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Emerman, A., Enari, Y., Epland, M. B., Erdmann, J., Ereditato, A., Erland, P. A., Errenst, M., Escalier, M., Escobar, C., Estrada Pastor, O., Etzion, E., Evans, G. E., Evans, H., Evans, M. O., Ezhilov, A., Fabbri, F., Fabbri, L., Fabiani, V., Facini, G., Fakhrutdinov, R. M., Falciano, S., Falke, P. J., Falke, S., Faltova, J., Fang, Y., Fanourakis, G., Fanti, M., Faraj, M., Farbin, A., Farilla, A., Farina, E. M., Farooque, T., Farrington, S. M., Farthouat, P., Fassi, F., Fassnacht, P., Fassouliotis, D., Faucci Giannelli, M., Fawcett, W. J., Fayard, L., Fedin, O. L., Fedorko, W., Fehr, A., Feickert, M., Feligioni, L., Fell, A., Feng, C., Feng, M., Fenton, M. J., Fenyuk, A. B., Ferguson, S. W., Ferrando, J., Ferrante, A., Ferrari, A., Ferrari, P., Ferrari, R., Ferreira de Lima, D. E., Ferrer, A., Ferrere, D., Ferretti, C., Fiedler, F., Filipcic, A., Filmer, E. K., Filthaut, F., Finelli, K. D., Fiolhais, M. C. N., Fiorini, L., Fischer, F., Fischer, J., Fisher, W. C., Fitschen, T., Fleck, I., Fleischmann, P., Flick, T., Flierl, B. M., Flores, L., Flores Castillo, L. R., Follega, F. M., Fomin, N., Foo, J. H., Forcolin, G. T., Forland, B. C., Formica, A., Forster, F. A., Forti, A. C., Fortin, E., Foti, M. G., Fournier, D., Fox, H., Francavilla, P., Francescato, S., Franchini, M., Franchino, S., Francis, D., Franco, L., Franconi, L., Franklin, M., Frattari, G., Fray, A. N., Freeman, P. M., Freund, B., Freund, W. S., Freundlich, E. M., Frizzell, D. C., Froidevaux, D., Frost, J. A., Fujimoto, M., Fukunaga, C., Fullana Torregrosa, E., Fusayasu, T., Fuster, J., Gabrielli, A., Gadatsch, S., Gadow, P., Gagliardi, G., Gagnon, L. G., Gallardo, G. E., Gallas, E. J., Gallop, B. J., Gamboa Goni, R., Gan, K. K., Ganguly, S., Gao, J., Gao, Y., Gao, Y. S., Garay Walls, F. M., Garcia, C., Garcia Navarro, J. E., Garcia Pascual, J. A., Garcia-Argos, C., Garcia-Sciveres, M., Gardner, R. W., Garelli, N., Gargiulo, S., Garner, C. A., Garonne, V., Gasiorowski, S. J., Gaspar, P., Gaudiello, A., Gaudio, G., Gauzzi, P., Gavrilenko, I. L., Gavrilyuk, A., Gay, C., Gaycken, G., Gazis, E. N., Geanta, A. A., Gee, C. M., Gee, C. N. P., Geisen, J., Geisen, M., Gemme, C., Genest, M. H., Geng, C., Gentile, S., George, S., Geralis, T., Gerlach, L. O., Gessinger-Befurt, P., Gessner, G., Ghasemi, S., Ghasemi Bostanabad, M., Ghneimat, M., Ghosh, A., Giacobbe, B., Giagu, S., Giangiacomi, N., Giannetti, P., Giannini, A., Giannini, G., Gibson, S. M., Gignac, M., Gil, D. T., Gilbert, B. J., Gillberg, D., Gilles, G., Gillwald, N. E. K., Gingrich, D. M., Giordani, M. P., Giraud, P. F., Giugliarelli, G., Giugni, D., Giuli, F., Gkaitatzis, S., Gkialas, I., Gkougkousis, E. L., Gkountoumis, P., Gladilin, L. K., Glasman, C., Glatzer, J., Glaysher, P. C. F., Glazov, A., Gledhill, G. R., Gnesi, I., Goblirsch-Kolb, M., Godin, D., Goldfarb, S., Golling, T., Golubkov, D., Gomes, A., Goncalves Gama, R., Goncalo, R., Gonella, G., Gonella, L., Gongadze, A., Gonnella, F., Gonski, J. L., Gonzalez de la Hoz, S., Gonzalez Fernandez, S., Gonzalez Lopez, R., Gonzalez Renteria, C., Gonzalez Suarez, R., Gonzalez-Sevilla, S., Gonzalvo Rodriguez, G. R., Goossens, L., Gorasia, N. A., Gorbounov, P. A., Gordon, H. A., Gorini, B., Gorini, E., Gorisek, A., Goshaw, A. T., Gostkin, M. I., Gottardo, C. A., Gouighri, M., Goussiou, A. G., Govender, N., Goy, C., Grabowska-Bold, I., Graham, E. C., Gramling, J., Gramstad, E., Grancagnolo, S., Grandi, M., Gratchev, V., Gravila, P. M., Gravili, F. G., Gray, C., Gray, H. M., Grefe, C., Gregersen, K., Gregor, I. M., Grenier, P., Grevtsov, K., Grieco, C., Grieser, N. A., Grillo, A. A., Grimm, K., Grinstein, S., Grivaz, J. -F., Groh, S., Gross, E., Grosse-Knetter, J., Grout, Z. J., Grud, C., Grummer, A., Grundy, J. C., Guan, L., Guan, W., Gubbels, C., Guenther, J., Guerguichon, A., Guerrero Rojas, J. G. R., Guescini, F., Guest, D., Gugel, R., Guida, A., Guillemin, T., Guindon, S., Guo, J., Guo, W., Guo, Y., Guo, Z., Gupta, R., Gurbuz, S., Gustavino, G., Guth, M., Gutierrez, P., Gutschow, C., Guyot, C., Gwenlan, C., Gwilliam, C. B., Haaland, E. S., Haas, A., Haber, C., Hadavand, H. K., Hadef, A., Haleem, M., Haley, J., Hall, J. J., Halladjian, G., Hallewell, G. D., Hamano, K., Hamdaoui, H., Hamer, M., Hamity, G. N., Han, K., Han, L., Han, S., Han, Y. F., Hanagaki, K., Hance, M., Handl, D. M., Hank, M. D., Hankache, R., Hansen, E., Hansen, J. B., Hansen, J. D., Hansen, M. C., Hansen, P. H., Hanson, E. C., Hara, K., Harenberg, T., Harkusha, S., Harrison, P. F., Hartman, N. M., Hartmann, N. M., Hasegawa, Y., Hasib, A., Hassani, S., Haug, S., Hauser, R., Havener, L. B., Havranek, M., Hawkes, C. M., Hawkings, R. J., Hayashida, S., Hayden, D., Hayes, C., Hayes, R. L., Hays, C. P., Hays, J. M., Hayward, H. S., Haywood, S. J., He, F., He, Y., Heath, M. P., Hedberg, V., Heggelund, A. L., Heidegger, C., Heidegger, K. K., Heidorn, W. D., Heilman, J., Heim, S., Heim, T., Heinemann, B., Heinrich, J. J., Heinrich, L., Hejbal, J., Helary, L., Held, A., Hellesund, S., Helling, C. M., Hellman, S., Helsens, C., Henderson, R. C. W., Heng, Y., Henkelmann, L., Henriques Correia, A. M., Herde, H., Hernandez Jimenez, Y., Herr, H., Herrmann, M. G., Herrmann, T., Herten, G., Hertenberger, R., Hervas, L., Herwig, T. C., Hesketh, G. G., Hessey, N. P., Hibi, H., Higashino, S., Higon-Rodriguez, E., Hildebrand, K., Hill, J. C., Hill, K. K., Hiller, K. H., Hillier, S. J., Hils, M., Hinchliffe, I., Hinterkeuser, F., Hirose, M., Hirose, S., Hirschbuehl, D., Hiti, B., Hladik, O., Hobbs, J., Hod, N., Hodgkinson, M. C., Hoecker, A., Hohn, D., Hohov, D., Holm, T., Holmes, T. R., Holzbock, M., Hommels, L. B. A. H., Hong, T. M., Honig, J. C., Honle, A., Hooberman, B. H., Hopkins, W. H., Horii, Y., Horn, P., Horyn, L. 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M., Xella, S., Xia, L., Xiang, J., Xiao, X., Xie, X., Xiotidis, I., Xu, D., Xu, H., Xu, L., Xu, T., Xu, W., Xu, Y., Xu, Z., Yabsley, B., Yacoob, S., Yallup, D. P., Yamaguchi, N., Yamaguchi, Y., Yamamoto, A., Yamatani, M., Yamazaki, T., Yamazaki, Y., Yan, J., Yan, Z., Yang, H. J., Yang, H. T., Yang, S., Yang, T., Yang, X., Yang, Y., Yang, Z., Yao, W. -M., Yap, Y. C., Yatsenko, E., Ye, H., Ye, J., Ye, S., Yeletskikh, I., Yexley, M. R., Yigitbasi, E., Yin, P., Yorita, K., Yoshihara, K., Young, C. J. S., Young, C., Yu, J., Yuan, R., Yue, X., Zaazoua, M., Zabinski, B., Zacharis, G., Zaffaroni, E., Zahreddine, J., Zaitsev, A. M., Zakareishvili, T., Zakharchuk, N., Zambito, S., Zanzi, D., Zeissner, S. V., Zeitnitz, C., Zemaityte, G., Zeng, J. C., Zenin, O., Zenis, T., Zerwas, D., Zgubic, M., Zhang, B., Zhang, D. F., Zhang, G., Zhang, J., Zhang, K., Zhang, L., Zhang, M., Zhang, R., Zhang, S., Zhang, X., Zhang, Y., Zhang, Z., Zhao, P., Zhao, Z., Zhemchugov, A., Zheng, Z., Zhong, D., Zhou, B., Zhou, C., Zhou, H., Zhou, M. S., Zhou, M., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, C., Zhu, H. L., Zhu, H., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zieminska, D., Zimine, N. I., Zimmermann, S., Zinonos, Z., Ziolkowski, M., Zivkovic, L., Zobernig, G., Zoccoli, A., Zoch, K., Zorbas, T. G., Zou, R., Zwalinski, L., DI BELLO, FRANCESCO ARMANDO, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Aad G., Abbott B., Abbott 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B., Charlton D.G., Charman T.P., Chatterjee M., Chau C.C., Che S., Chekanov S., Chekulaev S.V., Chelkov G.A., Chen B., Chen C., Chen C.H., Chen H., Chen H., Chen J., Chen J., Chen J., Chen S., Chen S.J., Chen X., Chen Y., Chen Y.-H., Cheng H.C., Cheng H.J., Cheplakov A., Cheremushkina E., Cherkaoui El Moursli R., Cheu E., Cheung K., Chevalérias T.J.A., Chevalier L., Chiarella V., Chiarelli G., Chiodini G., Chisholm A.S., Chitan A., Chiu I., Chiu Y.H., Chizhov M.V., Choi K., Chomont A.R., Chow Y.S., Christopher L.D., Chu M.C., Chu X., Chudoba J., Chwastowski J.J., Chytka L., Cieri D., Ciesla K.M., Cindro V., Cioară I.A., Ciocio A., Cirotto F., Citron Z.H., Citterio M., Ciubotaru D.A., Ciungu B.M., Clark A., Clark M.R., Clark P.J., Clawson S.E., Clement C., Coadou Y., Cobal M., Coccaro A., Cochran J., Coelho Lopes De Sa R., Cohen H., Coimbra A.E.C., Cole B., Colijn A.P., Collot J., Conde Muiño P., Connell S.H., Connelly I.A., Constantinescu S., Conventi F., Cooper-Sarkar A.M., Cormier F., Cormier K.J.R., Corpe L.D., Corradi M., Corrigan E.E., Corriveau F., Costa M.J., Costanza F., Costanzo D., Cowan G., Cowley J.W., Crane J., Cranmer K., Creager R.A., Crépé-Renaudin S., Crescioli F., Cristinziani M., Croft V., Crosetti G., Cueto A., Cuhadar Donszelmann T., Cui H., Cukierman A.R., Cunningham W.R., Czekierda S., Czodrowski P., Czurylo M.M., da Cunha Sargedas De Sousa M.J., da Fonseca Pinto J.V., da Via C., Dabrowski W., Dachs F., Dado T., Dahbi S., Dai T., Dallapiccola C., Dam M., D’Amen G., D’Amico V., Damp J., Dandoy J.R., Daneri M.F., Danninger M., Dao V., Darbo G., Dartsi O., Dattagupta A., Daubney T., D’Auria S., David C., Davidek T., Davis D.R., Dawson I., De K., de Asmundis R., de Beurs M., de Castro S., de Groot N., de Jong P., de la Torre H., de Maria A., de Pedis D., de Salvo A., de Sanctis U., de Santis M., de Santo A., de Vivie De Regie J.B., Dedovich D.V., Deiana A.M., Del Peso J., Delabat Diaz Y., Delgove D., Deliot F., Delitzsch C.M., della Pietra M., 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G., Zou, R., Zwalinski, L., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ATLAS (IHEF, IoP, FNWI), XENON (IHEF, IoP, FNWI), Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, Universidade do Minho, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Mirto, A, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, and ATLAS Collaboration, And
Subjects: Physics - Instrumentation and Detectors, Kjerne- og elementærpartikkelfysikk: 431 [VDP], Computer science, Physics::Instrumentation and Detectors, 01 natural sciences, High Energy Physics - Experiment, 030218 nuclear medicine & medical imaging, law.invention, Subatomär fysik, High Energy Physics - Experiment (hep-ex), 0302 clinical medicine, law, Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Preprocessor, Detectors and Experimental Techniques, physics.ins-det, Instrumentation, Mathematical Physics, FPGA, Settore FIS/01, Signal processing, Large Hadron Collider, Instrumentation and Detectors (physics.ins-det), trigger [calorimeter], ATLAS, Calorimeters, Trigger concepts and systems (hardware and software), Calorimeter, medicine.anatomical_structure, Nuclear and elementary particle physics: 431 [VDP], design [electronics], Particle Physics - Experiment, Computer hardware, performance, Ciências Naturais::Ciências Físicas, 530 Physics, Ciências Físicas [Ciências Naturais], Analog-to-digital converter, FOS: Physical sciences, 03 medical and health sciences, Atlas (anatomy), 0103 physical sciences, medicine, High Energy Physics, ddc:610, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Field-programmable gate array, signal processing, Science & Technology, hep-ex, 010308 nuclear & particles physics, business.industry, calorimeter: trigger, 530 Physik, calibration, analog-to-digital converter, pile-up, Experimental High Energy Physics, electronics: readout, business, readout [electronics], Energy (signal processing), electronics: design
Abstract: The PreProcessor of the ATLAS Level-1 Calorimeter Trigger prepares the analogue trigger signals sent from the ATLAS calorimeters by digitising, synchronising, and calibrating them to reconstruct transverse energy deposits, which are then used in further processing to identify event features. During the first long shutdown of the LHC from 2013 to 2014, the central components of the PreProcessor, the Multichip Modules, were replaced by upgraded versions that feature modern ADC and FPGA technology to ensure optimal performance in the high pile-up environment of LHC Run 2. This paper describes the features of the newMultichip Modules along with the improvements to the signal processing achieved., ANPCyT, YerPhI, Armenia, Australian Research Council, BMWFW, Austria, Austrian Science Fund (FWF), Azerbaijan National Academy of Sciences (ANAS), SSTC, Belarus, National Council for Scientific and Technological Development (CNPq), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada, Canada Foundation for Innovation, National Natural Science Foundation of China (NSFC), Departamento Administrativo de Ciencia, Tecnología e Innovación Colciencias, Ministry of Education, Youth & Sports - Czech Republic Czech Republic Government, Czech Republic Government, DNRF, Denmark, Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS), CEA-DRF/IRFU, France, Federal Ministry of Education & Research (BMBF), Max Planck Society, Greek Ministry of Development-GSRT, RGC and Hong Kong SAR, China, Israel Science Foundation, Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science, CNRST, Morocco, RCN, Norway, Portuguese Foundation for Science and Technology, MNE/IFA, Romania, MES of Russia, MESTD, Serbia, MSSR, Slovakia, Slovenian Research Agency - Slovenia, MIZS, Slovenia, Spanish Government, SRC, Sweden, Wallenberg Foundation, Sweden, SNSF Geneva, Switzerland, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, Science & Technology Facilities Council (STFC), United States Department of Energy (DOE), National Science Foundation (NSF), BCKDF, Canada, CANARIE, Canada, CRC, Canada, European Research Council (ERC), European Union (EU), French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, Greek NSRF, Greece, BSF-NSF, Israel, German-Israeli Foundation for Scientific Research and Development, La Caixa Banking Foundation, Spain, CERCA Programme Generalitat de Catalunya, Spain, PROMETEO, Spain, GenT Programmes Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust, NRC, Canada, CERN, ANID, Chile, Chinese Academy of Sciences, Ministry of Science and Technology, China, SRNSFG, Georgia, HGF, Germany, Netherlands Organization for Scientific Research (NWO) Netherlands Government, Ministry of Science and Higher Education, Poland, NCN, Poland, NRCKI, Russia Federation, JINR, DST/NRF, South Africa, SERI, Geneva, Switzerland, Cantons of Bern and Geneva, Switzerland, Compute Canada, Canada, Horizon 2020, Marie Sklodowska-Curie Actions, European Cooperation in Science and Technology (COST), EU-ESF, Greece
Published: 2020
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42. ATLAS data quality operations and performance for 2015-2018 data-taking

Author: Aad, Georges, Abbott, Brad, Abreu, Henso, Arduh, Francisco Anuar, Gwilliam, Carl, Haas, Andy, Haber, Carl, Hadavand, Haleh Khani, Hadef, Asma, Hageboeck, Stephan, Haleem, Mahsana, Haley, Joseph, Halladjian, Garabed, Hallewell, Gregory David, Arguin, Jean-Francois, Hamacher, Klaus, Hamal, Petr, Hamano, Kenji, Hamdaoui, Hassane, Hamer, Matthias, Hamity, Guillermo Nicolas, Han, Kunlin, Han, Liang, Han, Shuo, Han, Yi Fei, Argyropoulos, Spyridon, Hanagaki, Kazunori, Hance, Michael, Handl, David Michael, Haney, Bijan, Hankache, Robert, Hansen, Eva, Hansen, Jorgen Beck, Hansen, Jorn Dines, Hansen, Maike Christina, Hansen, Peter Henrik, Arling, Jan-Hendrik, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartmann, Nikolai Marcel, Hasegawa, Yoji, Hasib, Ahmed, Hassani, Samira, Haug, Sigve, Armbruster, Aaron James, Hauser, Reiner, Havener, Laura Brittany, Havranek, Miroslav, Hawkes, Christopher, Hawkings, Richard, Hayden, Daniel, Hayes, Christopher, Hayes, Robin Leigh, Hays, Chris, Hays, Jonathan Michael, Armstrong, Alexander III, Hayward, Helen, Haywood, Stephen, He, Fudong, Heath, Matthew Peter, Hedberg, Vincent, Heelan, Louise, Heer, Sebastian, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse, Arnaez, Olivier, Heim, Sarah, Heim, Timon Frank-thomas, Heinemann, Beate, Heinrich, Jochen Jens, Heinrich, Lukas, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Arnold, Hannah, Hellman, Sten, Helsens, Clement, Henderson, Robert, Heng, Yang, Henkelmann, Lars, Henkelmann, Steffen, Henriques Correia, Ana Maria, Herde, Hannah, Herget, Verena, Hernandez Jimenez, Yesenia, Arrubarrena Tame, Zulit Paola, Herr, Holger, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Gregor, Hertenberger, Ralf, Hervas, Luis, Herwig, Theodor Christian, Hesketh, Gavin Grant, Hessey, Nigel, Higashida, Akihiro, Artoni, Giacomo, Higashino, Satoshi, Higon-Rodriguez, Emilio, Hildebrand, Kevin, Hill, John, Hill, Kurt Keys, Hiller, Karl Heinz, Hillier, Stephen, Hils, Maximilian, Hinchliffe, Ian, Hinterkeuser, Florian, Abulaiti, Yiming, Artz, Sebastian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Hladik, Ondrej, Hlaluku, Dingane Reward, Hoad, Xanthe, Hobbs, John, Hod, Noam, Hodgkinson, Mark, Asai, Shoji, Hoecker, Andreas, Hohn, David, Hohov, Dmytro, Holm, Tanja, Holmes, Tova Ray, Holzbock, Michael, Hommels, Bart, Honda, Shunsuke, Hong, Tae Min, Honig, Jan Cedric, Asawatavonvanich, Thanawat, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter Howard, Horii, Yasuyuki, Horn, Philipp, Horyn, Lesya Anna, Hou, Suen, Hoummada, Abdeslam, Howarth, James, Hoya, Joaquin, Asbah, Nedaa, Hrabovsky, Miroslav, Hrdinka, Julia, Hristova, Ivana, Hrivnac, Julius, Hrynevich, Aliaksei, Hryn'ova, Tetiana, Hsu, Pai-hsien Jennifer, Hsu, Shih-Chieh, Hu, Qipeng, Hu, Shuyang, Asimakopoulou, Eleni Myrto, Hu, Yi Fan, Huang, Dan Ping, Huang, Yicong, Huang, Yanping, Hubacek, Zdenek, Hubaut, Fabrice, Huebner, Michael, Huegging, Fabian, Huffman, Todd Brian, Huhtinen, Mika, Asquith, Lily, Hunter, Robert Francis, Huo, Peng, Huseynov, Nazim, Huston, Joey, Huth, John, Hyneman, Rachel, Hyrych, Sofiia, Iacobucci, Giuseppe, Iakovidis, Georgios, Ibragimov, Iskander, Assahsah, Jihad, Iconomidou-Fayard, Lydia, Iengo, Paolo, Ignazzi, Rosanna, Igonkina, Olga, Iguchi, Ryunosuke, Iizawa, Tomoya, Ikegami, Yoichi, Ikeno, Masahiro, Iliadis, Dimitrios, Ilic, Nikolina, Assamagan, Ketevi, Iltzsche Speiser, Franziska, Introzzi, Gianluca, Iodice, Mauro, Iordanidou, Kalliopi, Ippolito, Valerio, Isacson, Max Fredrik, Ishino, Masaya, Islam, Wasikul, Issever, Cigdem, Istin, Serhat, Astalos, Robert, Ito, Fumiaki, Iturbe Ponce, Julia Mariana, Iuppa, Roberto, Ivina, Anna, Iwasaki, Hiroyuki, Izen, Joseph, Izzo, Vincenzo, Jacka, Petr, Jackson, Paul, Jacobs, Ruth Magdalena, Atkin, Ryan Justin, Jaeger, Benjamin Paul, Jain, Vivek, Jakel, Gunnar, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof Wojciech, Jansky, Roland, Janssen, Jens, Acharya, Bobby Samir, Atkinson, Markus, Janus, Michel, Janus, Piotr Andrzej, Jarlskog, Goeran, Javadov, Namig, Javurek, Tomas, Javurkova, Martina, Jeanneau, Fabien, Jeanty, Laura, Jejelava, Juansher, Jelinskas, Adomas, Atlay, Naim Bora, Jenni, Peter, Jeong, Jihyun, Jeong, Namgyun, Jezequel, Stephane, Ji, Haoshuang, Jia, Jiangyong, Jiang, Hai, Jiang, Yi, Jiang, Zihao, Jiggins, Stephen, Atmani, Hicham, Jimenez Morales, Fabricio Andres, Jimenez Pena, Javier, Jin, Shan, Jinaru, Adam, Jinnouchi, Osamu, Jivan, Harshna, Johansson, Per, Johns, Kenneth, Johnson, Christian, Jones, Roger, Augsten, Kamil, Jones, Samuel David, Jones, Sarah, Jones, Tim, Jongmanns, Jan, Jorge, Pedro, Jovicevic, Jelena, Ju, Xiangyang, Junggeburth, Johannes Josef, Juste Rozas, Aurelio, Kaczmarska, Anna, Avolio, Giuseppe, Kado, Marumi, Kagan, Harris, Kagan, Michael, Kahn, Alan, Kahra, Christian, Kaji, Toshiaki, Kajomovitz, Enrique, Kalderon, Charles William, Kaluza, Adam, Kamenshchikov, Andrey, Avramidou, Rachel Maria, Kaneda, Michiru, Kang, Nathan Jihoon, Kang, Shuaiyan, Kanjir, Luka, Kano, Yuya, Kantserov, Vadim, Kanzaki, Junichi, Kaplan, Laser Seymour, Kar, Deepak, Karava, Kla, Ayoub, Mohamad Kassem, Kareem, Mohammad Jawad, Karpov, Sergey, Karpova, Zoya, Kartvelishvili, Vakhtang, Karyukhin, Andrey, Kashif, Lashkar, Kass, Richard, Kastanas, Alex, Kato, Chikuma, Katzy, Judith, Azoulay, Adam Maxwell, Kawade, Kentaro, Kawagoe, Kiyotomo, Kawaguchi, Tomomi, Kawamoto, Tatsuo, Kawamura, Gen, Kay, Ellis, Kazanin, Vassili, Keeler, Richard, Kehoe, Robert, Keller, John Stakely, Azuelos, Georges, Kellermann, Edgar, Kelsey, Daniel, Kempster, Jacob Julian, Kendrick, James Andrew, Kennedy, Kiley Elizabeth, Kepka, Oldrich, Kersten, Susanne, Kersevan, Borut Paul, Ketabchi Haghighat, Sana, Khader, Mazin, Bachacou, Henri, Khalil-Zada, Farkhad, Khandoga, Mykola, Khanov, Alexander, Kharlamov, Alexey, Kharlamova, Tatyana, Khoda, Elham E, Khodinov, Alexander, Khoo, Teng Jian, Khramov, Evgeniy, Khubua, Jemal, Achkar, Baida, Bachas, Konstantinos, Kido, Shogo, Kiehn, Moritz, Kilby, Callum Robert, Kim, Young-Kee, Kimura, Naoki, Kind, Oliver, King, Barry, Kirchmeier, David, Kirk, Julie, Kiryunin, Andrey, Backes, Moritz, Kishimoto, Tomoe, Kisliuk, Dylan Perry, Kitali, Vincent, Kivernyk, Oleh, Klapdor-kleingrothaus, Thorwald, Klassen, Martin, Klein, Matthew Henry, Klein, Max, Klein, Uta, Kleinknecht, Konrad, Backman, Filip, Klimek, Pawel, Klimentov, Alexei, Klingl, Tobias, Klioutchnikova, Tatiana, Klitzner, Felix Fidelio, Kluit, Peter, Kluth, Stefan, Kneringer, Emmerich, Knoops, Edith B F G, Knue, Andrea, Bagnaia, Paolo, Kobayashi, Dai, Kobayashi, Tomio, Kobel, Michael, Kocian, Martin, Kodama, Takafumi, Kodys, Peter, Koenig, Philipp Thomas, Koffas, Thomas, Koehler, Nicolas Maximilian, Koi, Tatsumi, Bahmani, Marzieh, Kolb, Mathis, Koletsou, Iro, Komarek, Tomas, Kondo, Takahiko, Koeneke, Karsten, Kong, Albert Xing Yi, Koenig, Adriaan, Kono, Takanori, Konoplich, Rostislav, Konstantinides, Vasilis, Baluch Bahrasemani, Sina, Konstantinidis, Nikolaos, Konya, Balazs, Kopeliansky, Revital, Koperny, Stefan, Korcyl, Krzysztof, Kordas, Konstantinos, Koren, Guy, Korn, Andreas, Korolkov, Ilya, Korolkova, Elena, Bailey, Adam, Korotkova, Natalia, Kortner, Oliver, Kortner, Sandra, Kosek, Tomas, Kostyukhin, Vadim, Kotsokechagia, Anastasia, Kotwal, Ashutosh, Koulouris, Aimilianos, Kourkoumeli-Charalampidi, Athina, Kourkoumelis, Christine, Bailey, Virginia Ruth, Kourlitis, Evangelos, Kouskoura, Vasiliki, Kowalewska, Anna Bozena, Kowalewski, Robert Victor, Kozakai, Chihiro, Kozanecki, Witold, Kozhin, Anatoly, Kramarenko, Viktor, Kramberger, Gregor, Krasnopevtsev, Dimitrii, Baines, John, Krasny, Mieczyslaw Witold, Krasznahorkay, Attila, Krauss, Dominik, Kremer, Jakub Andrzej, Kretzschmar, Jan, Krieger, Peter, Krieter, Ferdinand, Krishnan, Anjali, Krizka, Karol, Kroeninger, Kevin, Bajic, Milena, Kroha, Hubert, Kroll, Jiri, 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Cristinel, De Almeida Dias, Flavia, Dias DO Vale, Tiago, Amaral Coutinho, Yara, Diaz, Marco Aurelio, Dickinson, Jennet, Diehl, Edward, Dietrich, Janet, Díez Cornell, Sergio, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen, Dittus, Fido, Djama, Fares, Ambler, Alessandro, Djobava, Tamar, Djuvsland, Julia Isabell, Barros do Vale, Maria Aline, Dobre, Monica, Dodsworth, David, Doglioni, Caterina, Dolejsi, Jiri, Dolezal, Zdenek, Donadelli, Marisilvia, Dong, Binbin, Ambroz, Luca, Donini, Julien, D'onofrio, Adelina, D'Onofrio, Monica, Dopke, Jens, Doria, Alessandra, Dova, Maria-Teresa, Doyle, Tony, Drechsler, Eric, Dreyer, Etienne, Dreyer, Timo, Amelung, Christoph, Drobac, Alec Swenson, Du, Dongshuo, Duan, Yanyun, Dubinin, Filipp, Dubovsky, Michal, Dubreuil, Arnaud, Duchovni, Ehud, Duckeck, Guenter, Ducourthial, Audrey, Ducu, Otilia Anamaria, Amidei, Dante Eric, Duda, Dominik, Dudarev, Alexey, Dudder, Andreas Christian, Duffield, Emily Marie, Duflot, Laurent, Duehrssen, Michael, Dulsen, Carsten, Dumancic, Mirta, Dumitriu, Ana Elena, Duncan, Anna Kathryn, Abouzeid, Ossama, Amor Dos Santos, Susana Patricia, Dunford, Monica, Duperrin, Arnaud, Duran Yildiz, Hatice, Dueren, Michael, Durglishvili, Archil, Duschinger, Dirk, Dutta, Baishali, Duvnjak, Damir, Dyckes, George, Dyndal, Mateusz, Amoroso, Simone, Dysch, Samuel, Dziedzic, Bartosz Sebastian, Ecker, Katharina Maria, Edgar, Ryan Christopher, Eggleston, Michael Glenn, Eifert, Till, Eigen, Gerald, Einsweiler, Kevin, Ekelof, Tord, El Jarrari, Hassnae, Amrouche, Cherifa Sabrina, El Kosseifi, Rima, Ellajosyula, Venugopal, Ellert, Mattias, Ellinghaus, Frank, Elliot, Alison, Ellis, Nicolas, Elmsheuser, Johannes, Elsing, Markus, Emeliyanov, Dmitry, Emerman, Alexander, An, Fenfen, Enari, Yuji, Epland, Matthew Berg, Erdmann, Johannes, Ereditato, Antonio, Errenst, Martin, Escalier, Marc, Escobar, Carlos, Estrada Pastor, Oscar, Etzion, Erez, Evans, Hal, Anastopoulos, Christos, Ezhilov, Alexey, Fabbri, Federica, Fabbri, Laura, Fabiani, Veronica, Facini, Gabriel John, Faisca Rodrigues Pereira, Rui Miguel, Fakhrutdinov, Rinat, Falciano, Speranza, Falke, Peter Johannes, Falke, Saskia, Andari, Nansi, Faltova, Jana, Fang, Yi, Fang, Yaquan, Fanourakis, Georgios, Fanti, Marcello, Faraj, Mohammed, Farbin, Amir, Farilla, Addolorata, Farina, Edoardo Maria, Farooque, Trisha, Andeen, Timothy, FARRELL, Steven, Farrington, Sinead, Farthouat, Philippe, Fassi, Farida, Fassnacht, Patrick, Fassouliotis, Dimitrios, Faucci Giannelli, Michele, Fawcett, William James, Fayard, Louis, Fedin, Oleg, Anders, Christoph Falk, Fedorko, Woiciech, Fehr, Armin, Feickert, Matthew, Feligioni, Lorenzo, Fell, Alexandra, Feng, Cunfeng, Feng, Minyu, Fenton, Michael James, Fenyuk, Alexander, Ferguson, Sarah Whitney, Anders, John Kenneth, Ferrando, James, Ferrante, Andrew, Ferrari, Arnaud, Ferrari, Pamela, Ferrari, Roberto, Ferreira de Lima, Danilo Enoque, Ferrer, Antonio, Ferrere, Didier, Ferretti, Claudio, Fiedler, Frank, Andreazza, Attilio, Filipcic, Andrej, Filthaut, Frank, Finelli, Kevin Daniel, Fiolhais, Miguel, Fiorini, Luca, Fischer, Florian Christoph, Fisher, Wade Cameron, Fleck, Ivor, Fleischmann, Philipp, Fletcher, Rob Roy Mac Gregor, Abraham, Nicola, Andrei, George Victor, Flick, Tobias, Flierl, Bernhard Matthias, Flores, Lucas Macrorie, Flores Castillo, Luis, Follega, Francesco Maria, Fomin, Nikolai, Foo, Joel Hengwei, Forcolin, Giulio Tiziano, Formica, Andrea, Foerster, Fabian Alexander, Anelli, Christopher Ryan, Forti, Alessandra, Foster, Andrew Geoffrey, Foti, Maria Giovanna, Fournier, Daniel, Fox, Harald, Francavilla, Paolo, Francescato, Simone, Franchini, Matteo, Franchino, Silvia, Francis, David, Angelidakis, Stylianos, Franconi, Laura, Franklin, Melissa, Fray, Antony, Freeman, Patrick Moriishi, Freund, Benjamin, Spolidoro Freund, Werner, Freundlich, Elena Murielle, Frizzell, Dylan Cooper, Froidevaux, Daniel, Frost, James, Angerami, Aaron, Fukunaga, Chikara, Fullana Torregrosa, Esteban, Fumagalli, Elisa, Fusayasu, Takahiro, Fuster, Juan, Gabrielli, Alessandro, Gabrielli, Andrea, Gadatsch, Stefan, Gadow, Paul Philipp, Gagliardi, Guido, Anisenkov, Alexey, Gagnon, Louis Guillaume, Galea, Cristina, Galhardo, Bruno, Gallardo, Gabriel Emmanuel, Gallas, Elizabeth, Gallop, Bruce, Galster, Gorm Aske Gram, Gamboa Goni, Rodrigo, Gan, KK, Ganguly, Sanmay, Annovi, Alberto, Gao, Jun, Gao, Yanyan, Gao, Yongsheng, Garcia, Carmen, García Navarro, José Enrique, Garcia Pascual, Juan Antonio, Garcia Argos, Carlos, Garcia-Sciveres, Maurice, Gardner, Robert, Garelli, Nicoletta, Antel, Claire, Gargiulo, Simona, Garner, Christopher Andrew, Garonne, Vincent, Gasiorowski, Sean Joseph, Do Nascimento Gaspar, Philipp, Gaudiello, Andrea, Gaudio, Gabriella, Gavrilenko, Igor, Gavrilyuk, Alexander, Gay, Colin, Anthony, Matthew Thomas, Gaycken, Goetz, Gazis, Evangelos, Geanta, Andrei Alexandru, Gee, Carolyn Mei, Gee, Norman, Geisen, Jannik, Geisen, Marc, Gemme, Claudia, Genest, Marie-Helene, Geng, Cong, Antipov, Egor, Gentile, Simonetta, George, Simon, Geralis, Theodoros, Gerlach, Lino Oscar, Gessinger-Befurt, Paul, Gessner, Gregor, Ghasemi, Sara, Ghasemi Bostanabad, Meisam, Ghneimat, Mazuza, Ghosh, Aishik, Antonelli, Mario, Ghosh, Anindya, Giacobbe, Benedetto, Giagu, Stefano, Giangiacomi, Nico, Giannetti, Paola, Giannini, Antonio, Giannini, Giulia, Gibson, Stephen, Gignac, Matthew, Gillberg, Dag Ingemar, Abramowicz, Halina, Antrim, Daniel Joseph, Gilles, Geoffrey, Gingrich, Douglas, Giordani, MarioPaolo, Giraud, Pierre-Francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, Stamatios, Gkialas, Ioannis, Gkougkousis, Evangelos, Anulli, Fabio, Gkountoumis, Panagiotis, Gladilin, Leonid, Glasman, Claudia, Glatzer, Julian Maximilian Volker, Glaysher, Paul, Glazov, Alexandre, Gledhill, Galen Rhodes, Goblirsch-Kolb, Maximilian, Godin, Dominique, Goldfarb, Steven, Aoki, Masato, Golling, Tobias, Golubkov, Dmitry, Gomes, Agostinho, Goncalves Gama, Rafael, Goncalo, Ricardo, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Aparisi Pozo, Javier Alberto, Gonzalez de la Hoz, Santiago, Gonzalez-Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr Andreevich, Gordon, Howard, Gorini, Benedetto, Gorini, Edoardo, Gorisek, Andrej, Aperio Bella, Ludovica, Goshaw, Alfred, Gostkin, Mikhail Ivanovitch, Gottardo, Carlo Alberto, Gouighri, Mohamed, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Gozani, Eitan, Grabowska-Bold, Iwona, Graham, Emily Charlotte, Araque Espinosa, Juan Pedro, Gramling, Johanna, Gramstad, Eirik, Grancagnolo, Sergio, Grandi, Mario, Gratchev, Vadim, Gravila, Paul Mircea, Gravili, Francesco Giuseppe, Gray, Chloe, Gray, Heather, Grefe, Christian, Araujo Ferraz, Victor, Gregersen, Kristian, Gregor, Ingrid-Maria, Grenier, Philippe, Grevtsov, Kirill, Grieco, Chiara, Grieser, Nathan Allen, Grillo, Alexander, Grimm, Kathryn, Grinstein, Sebastian, Grivaz, Jean-Francois, Araujo Pereira, Rodrigo, Groh, Sabrina, Gross, Eilam, Grosse-Knetter, Jorn, Grout, Zara Jane, Grud, Christopher, Grummer, Aidan, Guan, Liang, Guan, Wen, Gubbels, Christopher, Guenther, Jaroslav, Arcangeletti, Chiara, Guerguichon, Antinea, Guerrero Rojas, Jesus, Guescini, Francesco, Guest, Daniel, Gugel, Ralf, Guillemin, Thibault, Guindon, Stefan, Gul, Umar, Guo, Jun, Guo, Wen, Arce, Ayana, Guo, Yicheng, Guo, Ziyu, Gupta, Ruchi, Gurbuz, Saime, Gustavino, Giuliano, Guth, Manuel, Gutierrez, Phillip, Gutschow, Christian, Guyot, Claude, Gwenlan, Claire, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2369, ATLAS (IHEF, IoP, FNWI), XENON (IHEF, IoP, FNWI), Universidade do Minho, Centre de Physique des Particules de Marseille (CPPM), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), ATLAS, Aad, G., Abbott, B., Abbott, D. 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G., Zou, R., Zwalinski, L., Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique 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T., Sforza F., Sfyrla A., Shabalina E., Shahinian J.D., Shaikh N.W., Shaked Renous D., Shan L.Y., Shank J.T., Shapiro M., Sharma A., Sharma A.S., Shatalov P.B., Shaw K., Shaw S.M., Shehade M., Shen Y., Sherman A.D., Sherwood P., Shi L., Shimizu S., Shimmin C.O., Shimogama Y., Shimojima M., Shipsey I.P.J., Shirabe S., Shiyakova M., Shlomi J., Shmeleva A., Shochet M.J., Shojaii J., Shope D.R., Shrestha S., Shrif E.M., Shulga E., Sicho P., Sickles A.M., Sidebo P.E., Sideras Haddad E., Sidiropoulou O., Sidoti A., Siegert F., Sijacki D., Silva M.J., Silva Oliveira M.V., Silverstein S.B., Simion S., Simoniello R., Simsek S., Sinervo P., Sinetckii V., Sinev N.B., Singh S., Sioli M., Siral I., Yu Sivoklokov S., Sjölin J., Skorda E., Skubic P., Slawinska M., Sliwa K., Slovak R., Smakhtin V., Smart B.H., Smiesko J., Smirnov N., Yu Smirnov S., Smirnov Y., Smirnova L.N., Smirnova O., Smith J.W., Smizanska M., Smolek K., Smykiewicz A., Snesarev A.A., Snoek H.L., Snyder I.M., Snyder S., Sobie R., Soffer A., S∅gaard A., Sohns F., Solans Sanchez C.A., Yu Soldatov E., Soldevila U., Solodkov A.A., Soloshenko A., Solovyanov O.V., Solovyev V., Sommer P., Son H., Song W., Song W.Y., Sopczak A., Sopio A.L., Sopkova F., Sotiropoulou C.L., Sottocornola S., Soualah R., Soukharev A.M., South D., Spagnolo S., Spalla M., Spangenberg M., Spanò F., Sperlich D., Spieker T.M., Spigo G., Spina M., Spiteri D.P., Spousta M., Stabile A., Stamas B.L., Stamen R., Stamenkovic M., Stanecka E., Stanislaus B., Stanitzki M.M., Stankaityte M., Stapf B., Starchenko E.A., Stark G.H., Stark J., Stark S.H., Staroba P., Starovoitov P., Stärz S., Staszewski R., Stavropoulos G., Stegler M., Steinberg P., Steinhebel A.L., Stelzer B., Stelzer H.J., Stelzer-Chilton O., Stenzel H., Stevenson T.J., Stewart G.A., Stockton M.C., Stoicea G., Stolarski M., Stonjek S., Straessner A., Strandberg J., Strandberg S., Strauss M., Strizenec P., Ströhmer R., Strom D.M., Stroynowski R., Strubig A., Stucci S.A., Stugu B., Stupak J., Styles N.A., Su D., Su W., Suchek S., Sulin V.V., Sullivan M.J., Sultan D.M.S., Sultansoy S., Sumida T., Sun S., Sun X., Suruliz K., Suster C.J.E., Sutton M.R., Suzuki S., Svatos M., Swiatlowski M., Swift S.P., Swirski T., Sydorenko A., Sykora I., Sykora M., Sykora T., Ta D., Tackmann K., Taenzer J., Taffard A., Tafirout R., Takai H., Takashima R., Takeda K., Takeshita T., Takeva E.P., Takubo Y., Talby M., Talyshev A.A., Tamir N.M., Tanaka J., Tanaka M., Tanaka R., Araya S.T., Tapprogge S., Tarek Abouelfadl Mohamed A., Tarem S., Tariq K., Tarna G., Tartarelli G.F., Tas P., Tasevsky M., Tashiro T., Tassi E., Tavares Delgado A., Tayalati Y., Taylor A.J., Taylor G.N., Taylor W., Tee A.S., Teixeira De Lima R., Teixeira-Dias P., Ten Kate H., Teoh J.J., Terada S., Terashi K., Terron J., Terzo S., Testa M., Teuscher R.J., Thais S.J., Theveneaux-Pelzer T., Thiele F., Thomas D.W., Thomas J.O., Thomas J.P., Thompson P.D., Thomsen L.A., Thomson E., Thorpe E.J., Ticse Torres R.E., Tikhomirov V.O., Tikhonov Y.A., Timoshenko S., Tipton P., Tisserant S., Todome K., Todorova-Nova S., Todt S., Tojo J., Tokár S., Tokushuku K., Tolley E., Tomiwa K.G., Tomoto M., Tompkins L., Tong B., Tornambe P., Torrence E., Torres H., Torró Pastor E., Tosciri C., Toth J., Tovey D.R., Traeet A., Treado C.J., Trefzger T., Tresoldi F., Tricoli A., Trigger I.M., Trincaz-Duvoid S., Trischuk D.T., Trischuk W., Trocmé B., Trofymov A., Troncon C., Trovatelli M., Trovato F., Truong L., Trzebinski M., Trzupek A., Tsai F., Tseng J.C.-L., Tsiareshka P.V., Tsirigotis A., Tsiskaridze V., Tskhadadze E.G., Tsopoulou M., Tsukerman I.I., Tsulaia V., Tsuno S., Tsybychev D., Tu Y., Tudorache A., Tudorache V., Tulbure T.T., Tuna A.N., Turchikhin S., Turgeman D., Turk Cakir I., Turner R.J., Turra R.T., Tuts P.M., Tzamarias S., Tzovara E., Ucchielli G., Uchida K., Ueda I., Ukegawa F., Unal G., Undrus A., Unel G., Ungaro F.C., Unno Y., Uno K., Urban J., Urquijo P., Usai G., Uysal Z., Vacek V., Vachon B., Vadla K.O.H., Vaidya A., Valderanis C., Valdes Santurio E., Valente M., Valentinetti S., Valero A., Valéry L., Vallance R.A., Vallier A., Valls Ferrer J.A., Van Daalen T.R., Van Gemmeren P., Van Vulpen I., Vanadia M., Vandelli W., Vandenbroucke M., Vandewall E.R., Vaniachine A., Vannicola D., Vari R., Varnes E.W., Varni C., Varol T., Varouchas D., Varvell K.E., Vasile M.E., Vasquez G.A., Vazeille F., Vazquez Furelos D., Vazquez Schroeder T., Veatch J., Vecchio V., Veen M.J., Veloce L.M., Veloso F., Veneziano S., Ventura A., Venturi N., Verbytskyi A., Vercesi V., Verducci M., Vergel Infante C.M., Vergis C., Verkerke W., Vermeulen A.T., Vermeulen J.C., Vetterli M.C., Viaux Maira N., Vicente Barreto Pinto M., Vickey T., Vickey Boeriu O.E., Viehhauser G.H.A., Vigani L., Villa M., Villaplana Perez M., Vilucchi E., Vincter M.G., Virdee G.S., Vishwakarma A., Vittori C., Vivarelli I., Vogel M., Vokac P., Von Buddenbrock S.E., Von Toerne E., Vorobel V., Vorobev K., Vos M., Vossebeld J.H., Vozak M., Vranjes N., Vranjes Milosavljevic M., Vrba V., Vreeswijk M., Vuillermet R., Vukotic I., Wagner P., Wagner W., Wagner-Kuhr J., Wahdan S., Wahlberg H., Walbrecht V.M., Walder J., Walker R., Walker S.D., Walkowiak W., Wallangen V., Wang A.M., Wang A.Z., Wang C., Wang F., Wang H., Wang H., Wang J., Wang J., Wang P., Wang Q., Wang R.-J., Wang R., Wang R., Wang S.M., Wang W.T., Wang W., Wang W.X., Wang Y., Wang Z., Wanotayaroj C., Warburton A., Ward C.P., Wardrope D.R., Warrack N., Washbrook A., Watson A.T., Watson M.F., Watts G., Waugh B.M., Webb A.F., Webb S., Weber C., Weber M.S., Weber S.A., Weber S.M., Weidberg A.R., Weingarten J., Weirich M., Weiser C., Wells P.S., Wenaus T., Wengler T., Wenig S., Wermes N., Werner M.D., Wessels M., Weston T.D., Whalen K., Whallon N.L., Wharton A.M., White A.S., White A., White M.J., Whiteson D., Whitmore B.W., Wiedenmann W., Wiel C., Wielers M., Wieseotte N., Wiglesworth C., Wiik-Fuchs L.A.M., Wilkens H.G., Wilkins L.J., Williams H.H., Williams S., Willis C., Willocq S., Wilson J.A., Wingerter-Seez I., Winkels E., Winklmeier F., Winston O.J., Winter B.T., Wittgen M., Wobisch M., Wolf A., Wolf T.M.H., Wolff R., Wölker R.W., Wollrath J., Wolter M.W., Wolters H., Wong V.W.S., Woods N.L., Worm S.D., Wosiek B.K., Woźniak K.W., Wraight K., Wu S.L., Wu X., Wu Y., Wyatt T.R., Wynne B.M., Xella S., Xi Z., Xia L., Xiao X., Xiotidis I., Xu D., Xu H., Xu L., Xu T., Xu W., Xu Z., Xu Z., Yabsley B., Yacoob S., Yajima K., Yallup D.P., Yamaguchi N., Yamaguchi Y., Yamamoto A., Yamatani M., Yamazaki T., Yamazaki Y., Yan Z., Yang H.J., Yang H.T., Yang S., Yang X., Yang Y., Yao W.-M., Yap Y.C., Yasu Y., Yatsenko E., Ye H., Ye J., Ye S., Yeletskikh I., Yexley M.R., Yigitbasi E., Yorita K., Yoshihara K., Young C.J.S., Young C., Yu J., Yuan R., Yue X., Yuen S.P.Y., Zaazoua M., Zabinski B., Zacharis G., Zaffaroni E., Zahreddine J., Zaitsev A.M., Zakareishvili T., Zakharchuk N., Zambito S., Zanzi D., Zaripovas D.R., Zeißner S.V., Zeitnitz C., Zemaityte G., Zeng J.C., Zenin O., Zeniš T., Zerwas D., Zgubič M., Zhang B., Zhang D.F., Zhang G., Zhang H., Zhang J., Zhang L., Zhang L., Zhang M., Zhang R., Zhang S., Zhang X., Zhang Y., Zhang Z., Zhang Z., Zhao P., Zhao Y., Zhao Z., Zhemchugov A., Zheng Z., Zhong D., Zhou B., Zhou C., Zhou M.S., Zhou M., Zhou N., Zhou Y., Zhu C.G., Zhu C., Zhu H.L., Zhu H., Zhu J., Zhu Y., Zhuang X., Zhukov K., Zhulanov V., Zieminska D., Zimine N.I., Zimmermann S., Zinonos Z., Ziolkowski M., Zivković L., Zobernig G., Zoccoli A., Zoch K., Zorbas T.G., Zou R., Zwalinski L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, and Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)
Subjects: Kjerne- og elementærpartikkelfysikk: 431 [VDP], DATA, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Data management, detector-systems performance, 01 natural sciences, SERVICE, High Energy Physics - Experiment, Subatomär fysik, purl.org/becyt/ford/1 [https], High Energy Physics - Experiment (hep-ex), Software, CERN, Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Instrumentation, Mathematical Physics, Operation, Large detector-systems performance, Settore FIS/01, Data processing, Large Hadron Collider, Atlas (topology), ROOT-S=13 TEV, Detector, Instrumentation and Detectors (physics.ins-det), ATLAS, GNAM, Nuclear and elementary particle physics: 431 [VDP], quality, Large detector systems for particle and astroparticle physics, Large, COLLISIONS, SEARCH, Particle Physics - Experiment, performance, 530 Physics, Ciências Naturais::Ciências Físicas, Real-time computing, Ciências Físicas [Ciências Naturais], FOS: Physical sciences, programming, 0103 physical sciences, ddc:610, High Energy Physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Science & Technology, 010308 nuclear & particles physics, business.industry, Data quality, purl.org/becyt/ford/1.3 [https], Collision, 530 Physik, monitoring, efficiency, Experimental High Energy Physics, Large detector systems for particle and astroparticle physic, data management, business
Abstract: The ATLAS detector at the Large Hadron Collider reads out particle collision data from over 100 million electronic channels at a rate of approximately 100 kHz, with a recording rate for physics events of approximately 1 kHz. Before being certified for physics analysis at computer centres worldwide, the data must be scrutinised to ensure they are clean from any hardware or software related issues that may compromise their integrity. Prompt identification of these issues permits fast action to investigate, correct and potentially prevent future such problems that could render the data unusable. This is achieved through the monitoring of detector-level quantities and reconstructed collision event characteristics at key stages of the data processing chain. This paper presents the monitoring and assessment procedures in place at ATLAS during 2015–2018 data-taking. Through the continuous improvement of operational procedures, ATLAS achieved a high data quality efficiency, with 95.6% of the recorded proton-proton collision data collected at √s=13 TeV certified for physics analysis., We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerbaijan; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; CONICYT, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSWandNCN, Poland; FCT, Portugal; MNE/IFA, Romania; MESofRussia andNRCKI, Russia Federation; JINR; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MINECO, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada and CRC, Canada; ERC, ERDF, Horizon 2020, Marie Sklodowska-Curie Actions and COST, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; CERCA Programme Generalitat de Catalunya and PROMETEO Programme Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom.r The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, theATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF(Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL (U.S.A.), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in ref. [40]., info:eu-repo/semantics/publishedVersion
Published: 2020
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43. WSN Design and Verification Using On-Board Executable Specifications

Author: Giuseppe Lo Re, Gloria Martorella, Daniele Peri, Salvatore Gaglio, Gaglio, Salvatore, Re, Giuseppe Lo, Martorella, Gloria, and Peri, Daniele
Subjects: Computer science, Information System, 02 engineering and technology, wireless sensor network, Software, 0202 electrical engineering, electronic engineering, information engineering, Electrical and Electronic Engineering, Embedded system, symbolic programming, Settore ING-INF/05 - Sistemi Di Elaborazione Delle Informazioni, Functional specification, business.industry, 020208 electrical & electronic engineering, Runtime verification, resource-constrained device, Computer Science Applications1707 Computer Vision and Pattern Recognition, computer.file_format, system specification, Computer Science Applications, Control and Systems Engineering, system programming, Executable, business, computer, Information Systems
Abstract: The gap between informal functional specifications and the resulting implementation in the chosen programming language is notably a source of errors in embedded systems design. In this paper, we discuss a methodology and a software platform aimed at coping with this issue in programming resource-constrained wireless sensor network nodes (WSNs). Whereas the typical development model for the WSNs is based on cross compilation, the proposed approach supports high-level symbolic coding of abstract models and distributed applications, as well as their test and their execution, directly on the target hardware. As a working example, we discuss the application of our methodology to specify the functional behavior of a radio transceiver chip. The resulting executable specifications are augmented with automatically generated runtime verification code. Our approach is also compared to code development for two prominent WSN general-purpose operating systems.
Published: 2019
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44. Pathogenesis of Congenital Malformations: Possible Role of Oxidative Stress

Author: Ugo Calabrese, Salvatore Arena, Donatella Di Fabrizio, Pietro Antonuccio, Enrica Antonelli, Carmelo Romeo, Flora Maria Peri, Pietro Impellizzeri, and Francesca Nascimben
Subjects: Heart Defects, Congenital, congenital malformations, newborns, oxidative stress, therapeutic strategies, Autosomal dominant polycystic kidney disease, medicine.disease_cause, Bioinformatics, Congenital Abnormalities, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Biliary Atresia, Pregnancy, Biliary atresia, Humans, Medicine, Child, Esophageal Atresia, 030304 developmental biology, 0303 health sciences, Fetus, business.industry, Obstetrics and Gynecology, Polycystic Kidney, Autosomal Dominant, medicine.disease, Review article, Oxidative Stress, Atresia, Pediatrics, Perinatology and Child Health, Female, Hernias, Diaphragmatic, Congenital, business, 030217 neurology & neurosurgery, Oxidative stress
Abstract: Congenital anomalies are important causes of morbidity and mortality in children. Oxidative stress (OS) is involved in the physiopathology of pregnancy-related congenital malformations. This review summarizes the role of OS in the pathogenesis of congenital malformations; in particular, its purpose is to describe how OS influences the development of heart congenital malformations, oesophageal atresia, biliary atresia, diaphragmatic hernia, and autosomal dominant polycystic kidney disease.Systematic review of previous studies about the role of OS in pregnancy and its possible effects in developing of congenital malformations. One electronic database (PubMed) was searched and reference lists were checked.An imbalance between the production of reactive oxygen species (ROS) and antioxidant defense can occur early in pregnancy and continue in the postnatal life, producing OS. It may destroy the signaling pathways needed for a correct embryogenesis leading to birth defects. In fact, cell functions, especially during embryogenesis, needs specific signaling pathways to regulate the development. These pathways are sensitive to both endogenous and exogenous factors; therefore, they can produce structural alterations of the developing fetus.Because OS plays a significant role in pathogenesis of congenital malformations, studies should be developed in order to better define their OS mechanisms and the beneficial effects of supplemental therapeutic strategies.· Oxidative stress is involved in the pathogenesis of congenital malformations.. · Heart malformations, oesophageal atresia, biliary atresia, diaphragmatic hernia, and autosomal dominant polycystic kidney are analyzed.. · A knowledge of pathomechanism of OS-related congenital malformations could be useful to prevent them..
Published: 2020
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45. Hubungan Anemia dengan Kualitas Hidup Pasien PGK yang Menjalani Hemodialisis

Author: Dita Amita and Peri Zuliani
Subjects: medicine.medical_specialty, business.industry, Anemia, Incidence (epidemiology), medicine.medical_treatment, Renal function, urologic and male genital diseases, medicine.disease, Uremia, Quality of life, Internal medicine, Chi-square test, Medicine, Hemodialysis, business, Kidney disease
Abstract: Chronic Kidney Disease (CKD) is a progressive and irreversible disorder of renal function, in which the body's ability to fail to maintain metabolism and balance of fluids and electrolytes, causing uremia. The purpose of this study in general was to determine the relationship between hemoglobin levels and quality of life in chronic kidney disease patients undergoing hemodialysis at dr. M. Yunus Bengkulu. This type of research is descriptive analytic with cross sectional approach. The study sample was 64 patients with CKD who underwent hemodialysis at the hemodialysis installation with accidental sampling technique. The results showed that most patients with chronic kidney disease who underwent haemodialysis (71.9%) had severe anemia and most (56.3%) had a poor quality of life. Chi square test results obtained ρ value 0,000 (α = 0.05). Conclusion, There is a statistically significant correlation between anemia and quality of life in CKD patients undergoing hemodialysis in the RDUD Dr. Hemodialysis room. M. Yunus. Suggested to Dr. Hospital M. Yunus Bengkulu to control the incidence and symptoms of anemia experienced by CKD patients. Keywords: Anemia, Hemodialysis, quality of life, CKD
Published: 2020
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46. Factors that Determine the Urge to Switch from E-Commerce into Social Commerce for Indonesian People

Author: Peri A. Manaf and Arif Budiman
Subjects: Indonesian, Commerce, business.industry, language, E-commerce, business, Social commerce, language.human_language
Published: 2020
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47. Increasing kidney grafts for transplantation

Author: Claudia Mercader, Meritxell Pérez, Nuria Esforzado, Lluis Peri, Alba Sierra, Mireia Musquera, Antonio Alcaraz, Fritz Diekmann, and David Paredes
Subjects: Adult, Male, Nephrology, medicine.medical_specialty, Tissue and Organ Procurement, Urology, 030232 urology & nephrology, Renal tumour, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, Internal medicine, medicine, Humans, Kidney transplantation, Aged, Retrospective Studies, Aged, 80 and over, Tumour excision, Kidney, business.industry, Middle Aged, medicine.disease, Kidney Transplantation, Kidney Neoplasms, Delayed Graft Function, Surgery, Transplantation, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, business
Abstract: The current pool of organs available for transplantation does not cover requirements, for this reason non-standard risk donors need to be incorporated into the pool. In this way, donors with small renal tumour are considered for transplantation after bench tumour excision. The aim of our study was to analyse our experience in using these grafts for transplantation. Retrospective analysis from our prospective accrued database of donors with incidental renal mass used for kidney transplantation between January 2007 and August 2018. Twenty kidney transplantations were performed, thirteen cases received the affected kidney (after tumour removal) and seven the contralateral kidney; from six living and eleven deceased donors. Donor and recipient median age was 58 years (range 22–82) and 56.5 years (range 38–74), respectively. Mean tumour diameter was 12.7 mm (SD 9.5). Tumours resulted in two benign lesions and fifteen renal cell carcinoma. Surgical margins were negative. Two cases presented with bleeding after reperfusion was solved without repercussion. One case presented with immediate vein thrombosis. None of them present delayed graft function. After a 69 month follow-up none of the donors or the recipients presented tumour recurrence. Kidneys with small incidental tumours seem to be a good option for kidney transplantation in selected patients after bench surgery excision with good functional and oncologic results. More studies and longer follow-up are needed to confirm these results.
Published: 2020
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48. Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

Author: Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, and Derek J. Leishman
Subjects: Drug, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Drug Industry, media_common.quotation_subject, Decision Making, hERG, Drug Evaluation, Preclinical, Reviews, Torsades de pointes, Review, Risk Assessment, 030226 pharmacology & pharmacy, QT interval, Electrocardiography, 03 medical and health sciences, 0302 clinical medicine, Drug Development, Torsades de Pointes, medicine, Animals, Humans, Repolarization, Pharmacology (medical), cardiovascular diseases, Intensive care medicine, media_common, Pharmacology, biology, Surrogate endpoint, business.industry, Arrhythmias, Cardiac, Drugs, Investigational, medicine.disease, nervous system diseases, Clinical trial, Long QT Syndrome, Drug development, 030220 oncology & carcinogenesis, biology.protein, business
Abstract: Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide. In use for over 15 years, the nonclinical International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) S7B and clinical ICH E14 guidances describe three core assays (S7B: in vitro hERG current & in vivo QTc studies; E14: thorough QT study) that are used to assess the potential of drugs to cause delayed ventricular repolarization. Incorporating these assays during nonclinical or human testing of novel compounds has led to a low prevalence of QTc‐prolonging drugs in clinical trials and no new drugs having been removed from the marketplace due to unexpected QTc prolongation. Despite this success, nonclinical evaluations of delayed repolarization still minimally influence ICH E14‐based strategies for assessing clinical QTc prolongation and defining proarrhythmic risk. In particular, the value of ICH S7B‐based “double‐negative” nonclinical findings (low risk for hERG block and in vivo QTc prolongation at relevant clinical exposures) is underappreciated. These nonclinical data have additional value in assessing the risk of clinical QTc prolongation when clinical evaluations are limited by heart rate changes, low drug exposures, or high‐dose safety considerations. The time has come to meaningfully merge nonclinical and clinical data to enable a more comprehensive, but flexible, clinical risk assessment strategy for QTc monitoring discussed in updated ICH E14 Questions and Answers. Implementing a fully integrated nonclinical/clinical risk assessment for compounds with double‐negative nonclinical findings in the context of a low prevalence of clinical QTc prolongation would relieve the burden of unnecessary clinical QTc studies and streamline drug development.
Published: 2020
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49. Medication omission rates in New Zealand residential aged care homes: a national description

Author: Stephanie M Garratt, Monique Jonas, Kathryn Peri, and Ngaire Kerse
Subjects: medicine.medical_specialty, Level data, medicine.medical_treatment, Medication omissions, Nursing, lcsh:Geriatrics, E-records, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Medication Errors, 030212 general & internal medicine, Aged care, Aged, Retrospective Studies, Rehabilitation, business.industry, Incidence (epidemiology), Medication administration, Pharmacoepidemiology, Hospitals, lcsh:RC952-954.6, Pharmaceutical Preparations, Family medicine, Geriatrics and Gerontology, Level of care, business, Care staff, 030217 neurology & neurosurgery, Research Article, New Zealand
Abstract: Background A medication omission is an event where a prescribed medication is not taken before the next scheduled dose. Medication omissions are typically classed as errors within Residential Aged Care (RAC) homes, as they have the potential to lead to harm if poorly managed, but may also stem from good clinical decision-making. This study aimed to quantify the incidence, prevalence, and types of medication omissions in RAC homes on a national scale, using a New Zealand-based sample. Methods We conducted retrospective pharmacoepidemiology of de-identified medication administration e-records from December 1st 2016 to December 31st 2017. Four tiers of de-identified data were collected: RAC home level data (ownership, levels of care), care staff level data (competency level/role), resident data (gender, age, level of care), and medication related data (omissions, categories of omissions, recorded reasons for omission). Data were analysed using SPSS version 24 and Microsoft Excel. Results A total of 11, 015 residents from 374 RAC homes had active medication charts; 8020 resided in care over the entire sample timeframe. A mean rate of 3.59 medication doses were omitted per 100 (±7.43) dispensed doses/resident. Seventy-three percent of residents had at least one dose omission. The most common omission category used was ‘not-administered’ (49.9%), followed by ‘refused’ (34.6%). The relationship between ownership type and mean rate of omission was significant (p = 0.002), corporate operated RAC homes had a slightly higher mean (3.73 versus 3.33), with greater variation. The most commonly omitted medications were Analgesics and Laxatives. Forty-eight percent of all dose omissions were recorded without a comment justifying the omission. Conclusions This unique study is the first to report rate of medication omissions per RAC resident over a one-year timeframe. Although the proportion of medications omitted reported in this study is less than previously reported by hospital-based studies, there is a significant relationship between a resident’s level of care, RAC home ownership types, and the rate of omission.
Published: 2020
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50. Spectrum of Cardiac Manifestations in COVID-19

Author: Yael Lichter, Philippe Taieb, Ariel Banai, Guy Baruch, Yaron Arbel, Ehud Rothschild, Yogev Peri, Yishay Szekely, Yan Topilsky, Amir Gal Oz, Ilan Merdler, and Aviram Hochstadt
Subjects: Male, 2019-20 coronavirus outbreak, Heart Diseases, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, 030204 cardiovascular system & hematology, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Original Research Articles, Physiology (medical), Correspondence, Pandemic, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Pandemics, Aged, Aged, 80 and over, biology, SARS-CoV-2, business.industry, COVID-19, heart ventricles, thromboembolism, Middle Aged, biology.organism_classification, Virology, Troponin, Echocardiography, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, Coronavirus Infections, Cardiology and Cardiovascular Medicine, business
Abstract: Supplemental Digital Content is available in the text., Background: Information on the cardiac manifestations of coronavirus disease 2019 (COVID-19) is scarce. We performed a systematic and comprehensive echocardiographic evaluation of consecutive patients hospitalized with COVID-19 infection. Methods: One hundred consecutive patients diagnosed with COVID-19 infection underwent complete echocardiographic evaluation within 24 hours of admission and were compared with reference values. Echocardiographic studies included left ventricular (LV) systolic and diastolic function and valve hemodynamics and right ventricular (RV) assessment, as well as lung ultrasound. A second examination was performed in case of clinical deterioration. Results: Thirty-two patients (32%) had a normal echocardiogram at baseline. The most common cardiac pathology was RV dilatation and dysfunction (observed in 39% of patients), followed by LV diastolic dysfunction (16%) and LV systolic dysfunction (10%). Patients with elevated troponin (20%) or worse clinical condition did not demonstrate any significant difference in LV systolic function compared with patients with normal troponin or better clinical condition, but they had worse RV function. Clinical deterioration occurred in 20% of patients. In these patients, the most common echocardiographic abnormality at follow-up was RV function deterioration (12 patients), followed by LV systolic and diastolic deterioration (in 5 patients). Femoral deep vein thrombosis was diagnosed in 5 of 12 patients with RV failure. Conclusions: In COVID-19 infection, LV systolic function is preserved in the majority of patients, but LV diastolic function and RV function are impaired. Elevated troponin and poorer clinical grade are associated with worse RV function. In patients presenting with clinical deterioration at follow-up, acute RV dysfunction, with or without deep vein thrombosis, is more common, but acute LV systolic dysfunction was noted in ≈20%.
Published: 2020
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