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The COVID-19 pandemic brought unprecedented challenges to higher education. The extraordinary challenges created by the pandemic required equally extraordinary efforts from faculty and other stakeholders to rapidly convert face-to-face classes to online/hybrid instruction. This rapid change was facilitated by use of a robust framework for not only making changes in short order but also sustaining the changes to reshape healthcare education for a post-pandemic future. To this end, the chapter discusses the effective use of Kotter's 8-step framework to successfully implement change in healthcare education at a college of pharmacy and allied health professions. This chapter discusses each step of Kotter's 8-step process to create, implement, and sustain change in pharmacy and allied health education. The model integrated people, processes, and effective strategies to create changes amid the pandemic (crisis). Lessons learned and implications for the future in a post-pandemic educational environment are presented.

Almost all breast cancers originate from epithelial cells lining the milk ducts in the breast. To this end, the study investigated the feasibility of localized transdermal delivery of α-santalol, a natural chemopreventive agent to the breast. Different α-santalol formulations (cream, solution and microemulsion) were developed and the in vitro permeability was studied using excised animal (porcine and rat) and human breast skin/mammary papilla (nipple). The in vivo biodistribution and efficacy studies were conducted in female rats. A chemical carcinogenesis model of breast cancer was used for the efficacy studies. Phospholipid based α-santalol microemulsion showed the highest penetration through the nipple and breast skin. Delivery of α-santalol through the entire breast (breast skin and nipple) in vivo in rats resulted in significantly higher concentration in the mammary gland compared to transdermal delivery through the breast skin or nipple. There was no measurable α-santalol concentration in the blood. Transdermal delivery of α-santalol reduced the tumor incidence and tumor multiplicity. Furthermore, the tumor size was significantly reduced with α-santalol treatment. The findings from this study demonstrate the feasibility of localized transdermal delivery of α-santalol for chemoprevention of breast cancer.

The main goal of this study is to overcome docetaxel (DTX) resistance in prostate cancer cells by combined delivery of eIF4E siRNA and DTX using dendrimer as a nanocarrier. To this end the objective of this study is to prepare, characterize and test the feasability of the combination delivery approach in-vitro in DTX sensitive and resistant prostate cancer cells. During the last evaluation period we prepared and characterized the dendrimer-DTX conjugate and dendrimer-siRNA complex. During this evaluation period our goal was to optimize the delivery system, develop the DTX resistant prostate cancer cells and test the in-vitro efficacy of the multifunctional delivery system. The DTX resistant prostate cancer cells were developed by treating PC3 cells with sub-therapeutic concentration of DTX for 9 months and it was found to overexpress eIF4E. The multifunctional therapeutic system was able to overcome the resistance in PC3 cells and lowered the IC50 value in drug resistant PC3 cells. The siRNA reduced the levels of eIF4E and Myc in PC3 cells. Overall the outcomes from this study demonstrate the feasibility of developing a therapeutic strategy for drug resistant prostate cancer. Our future studies will focus on further optimizing the delivery system and testing the efficacy in-vivo in prostate cancer mouse model.

Preformulation testing has a significant role in a drug discovery and development program, as it provides valuable feedback to the various discovery and development teams in enabling druggability during lead identification and optimization. In a generic setting, preformulation studies are mainly focused on developing a formulation that is bioequivalent to the innovator's product with the main objective of filing an abbreviated new drug application (ANDA). This article focuses on preformulation testing for oral solid dosage forms in a drug discovery setting. Keywords: preformulation testing; abbreviated new drug application (ANDA); drug discovery; oral solid dosage forms

The study was aimed at investigating localized topical drug delivery to the breast via mammary papilla (nipple). 5-fluorouracil (5-FU) and estradiol (EST) were used as model hydrophilic and hydrophobic compounds respectively. Porcine and human nipple were used for in-vitro penetration studies. The removal of keratin plug enhanced the drug transport through the nipple. The drug penetration was significantly higher through the nipple compared to breast skin. The drug’s lipophilicity had a significant influence on drug penetration through nipple. The ducts in the nipple served as a major transport pathway to the underlying breast tissue. Results showed that porcine nipple could be a potential model for human nipple. The topical application of 5-FU on the rat nipple resulted in high drug concentration in the breast and minimal drug levels in plasma and other organs. Overall, the findings from this study demonstrate the feasibility of localized drug delivery to the breast through nipple.

Skin cancer is the most prevalent of all cancers and its incidence is expected to increase substantially. UVB is major etiologic factor in the skin cancer development. Honokiol, a plant ligan isolated from bark and seed cones of Magnolia officinalis, has been shown to have chemopreventive effects on UVB-induced skin cancer development in our laboratory. The objectives of this investigation are to study chemopreventive effects of dose response of honokiol on UVB-induced skin tumor development in SKH-1mice and to prepare topical formulations of honokiol that deliver effective concentration of drug locally. Female SKH-1 mice were divided into 4 groups. Group 1 received acetone one hour before UVB treatment; Group 2, 3 and 4 received honokiol (0.2 ml of 30, 45 and 60 μg in acetone, topical) before each UVB treatment. Mice were treated with UVB dose of 30 mJ/cm2/day for 25 weeks. Tumor counts and group weights were taken weekly. Honokiol pretreated groups resulted in 36-78% reduction in tumor multiplicity compared to control. Honokiol pretreatment (60 μg) decreased tumor incidence by 40 %. Topical formulation of honokiol gel was prepared by using carbomer 940 as base and propylene glycol as penetration enhancer. Drug content and content uniformity were determined. Release studies and permeation studies were studied in detail. This study is supported by Translational Cancer Research Center funded as 2010 Research Initiative Center by the State of South Dakota Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4620. doi:10.1158/1538-7445.AM2011-4620