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Zusammenfassung Ziel der Studie Darstellung der Erwerbssituation und Suche nach Determinanten der Erwerbstätigkeit in Abhängigkeit der Symptomschwere bei geflüchteten Menschen mit posttraumatischer Belastung. Methodik Befragung 133 geflüchteter, in Deutschland lebender Menschen syrischer Herkunft mit posttraumatischer Belastungssymptomatik und explorative Datenanalyse. Ergebnisse Nach knapp 4 Jahren im Asylland ist ein Viertel der Teilnehmenden (27,1 %) erwerbstätig. Dabei stehen einer erwerbstätigen Frau 6 erwerbstätige Männer gegenüber (13,9 % vs. 86,1 %; p = 0,001). Zusammenhänge zwischen psychischer Gesundheit und Erwerbstätigkeit ließen sich darstellen (posttraumatische Belastung p = 0,039, Depressivität p = 0,020, Somatisierung p = 0,026). Hinsichtlich sozialer Unterstützung, Traumaerleben sowie Aufenthaltsstatus und -dauer zeigten sich keine Unterschiede zwischen Geflüchteten mit und ohne Erwerbstätigkeit. Schlussfolgerung Die aktuelle Analyse zur Erwerbssituation einer umschriebenen Gruppe syrischer Geflüchteter stellt die Bedeutung der psychischen Symptombelastung in den Mittelpunkt.

Syrian refugees residing in Germany often develop posttraumatic stress as a result of the Syrian civil war, their escape, and postmigration stressors. At the same time, there is a lack of adequate treatment options. The smartphone-based app Sanadak was developed to provide cognitive behavioral therapy-based self-help in the Arabic language for Syrian refugees with posttraumatic stress.The aim of this study was to evaluate the effectiveness and cost-effectiveness of the app.In a randomized controlled trial, eligible individuals were randomly allocated to the intervention group (IG; app use) or control group (CG; psychoeducational reading material). Data were collected during structured face-to-face interviews at 3 assessments (preintervention/baseline, postintervention/after 4 weeks, follow-up/after 4 months). Using adjusted mixed-effects linear regression models, changes in posttraumatic stress and secondary outcomes were investigated as intention-to-treat (ITT) and per-protocol (PP) analysis. Cost-effectiveness was evaluated based on adjusted mean total costs, quality-adjusted life years (QALYs), and cost-effectiveness acceptability curves using the net benefit approach.Of 170 screened individuals (aged 18 to 65 years), 133 were eligible and randomized to the IG (n=65) and CG (n=68). Although there was a pre-post reduction in posttraumatic stress, ITT showed no significant differences between the IG and CG after 4 weeks (Posttraumatic Diagnostic Scale for DSM-5, Diff -0.90, 95% CI -0.24 to 0.47; P=.52) and after 4 months (Diff -0.39, 95% CI -3.24 to 2.46; P=.79). The same was true for PP. Regarding secondary outcomes, ITT indicated a treatment effect for self-stigma: after 4 weeks (Self-Stigma of Mental Illness Scale/SSMIS-stereotype agreement: d=0.86, 95% CI 0.46 to 1.25; stereotype application: d=0.60, 95% CI 0.22 to 0.99) and after 4 months (d=0.52, 95% CI 0.12 to 0.92; d=0.50, 95% CI 0.10 to 0.90), the IG showed significantly lower values in self-stigma than the CG. ITT showed no significant group differences in total costs and QALYs. The probability of cost-effectiveness was 81% for a willingness-to-pay of €0 per additional QALY but decreased with increasing willingness-to-pay.Sanadak was not more effective in reducing mild to moderate posttraumatic stress in Syrian refugees than the control condition nor was it likely to be cost-effective. Therefore, Sanadak is not suitable as a standalone treatment. However, as the app usability was very good, no harms detected, and stigma significantly reduced, Sanadak has potential as a bridging aid within a stepped and collaborative care approach.German Clinical Trials Register DRKS00013782; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTMLTRIAL_ID=DRKS00013782.RR2-10.1186/s12888-019-2110-y.

Refugees who have fled from the ongoing civil war in Syria that arrived in Germany often develop post-traumatic stress symptoms (PTSS). The aim of this study was to determine health care services utilization (HCSU), health care costs and health-related quality of life (HrQoL) of Syrian refugees with mild to moderate PTSS without current treatment in Germany. The study was based on the baseline sample of a randomized controlled trial of a self-help app for Syrian refugees with PTSS (n = 133). HCSU and HrQoL based on the EQ-5D-5L and its visual analogue scale (EQ-VAS) were assessed with standardized interviews. Annual health care costs were calculated using extrapolated four-month HCSU and standardized unit costs. Associations between health care costs, HrQoL and PTSS severity were examined using generalized linear models. Overall, 85.0% of the sample utilized health care services within four months. The mean total annual health care costs were EUR 1920 per person. PTSS severity was not associated with health care costs. The EQ-5D-5L index score and the EQ-VAS score was 0.82 and 73.6, respectively. For Syrian refugees with higher PTSS severity, the EQ-5D-5L index score was lower (−0.17, p &lt, 0.001). The HCSU and the resulting health care costs of Syrian refugees with mild to moderate PTSS without current treatment are low and those with a higher PTSS severity had a lower HrQoL.

Background Cancer is one of the most common causes of death. The period of time between receiving a terminal diagnosis of cancer and the death of a loved one has been operationalized as pre-loss grief and, more recently, as preparedness for death. Originally, grief before loss was thought to have positive effects on the bereavement outcome, but some studies have revealed contradictory findings. This systematic review investigates definitions and measurement tools of pre-loss grief and preparedness for death, as well as the associations of both constructs with caregiver characteristics, pre-loss psychological aspects and post-loss adjustment among caregivers of people living with terminal cancer. Methods PubMed/Medline, PsycINFO and Web of Science were searched for studies published up until October 2020. Quantitative empirical studies from peer reviewed journals were included if a measurement tool for pre-loss grief or preparedness for death was used and if they focused on adult caregivers of adult people with cancer in an end-of-life trajectory and were excluded when they were not written in English or were descriptive/qualitative studies. Quality assessment of all studies was performed. Results Most studies used convenience samples and had a mean number of 725 participants. Overall, 16,326 participants in 35 articles were included and narratively synthesized. High levels of pre-loss grief, as well as low levels of perceived preparedness for death, were associated with poor post-loss adjustment (e.g., prolonged grief, depressive symptoms, etc.). Conclusions Caregivers with high levels of pre-loss grief and low levels of preparedness for the death of their loved one would benefit from targeted support for post-loss adjustment. Results are limited by an inconsistent operationalization of both constructs.

Obesity and depression are prevalent complications during pregnancy and associated with severe health risks for the mother and the child. The co-occurrence of both conditions may lead to a particular high-risk group. This review provides a systematic overview of the association between pre-pregnancy obesity and antenatal or postnatal depression. We conducted a systematic electronic literature search for English language articles published between January 1990 and March 2017. Inclusion criteria were (a) adult pregnant women, (b) women with pre-pregnancy obesity and normal weight controls, (c) definition of obesity according to the IOM 1990/2009 criteria, (d) established depression measure, and (e) report on the association between pre-pregnancy obesity and antenatal or postnatal depression. Fourteen (eight prospective (PS), six cross-sectional (CS)) studies were included. One study reported data from a large community-based sample, and one reported cross-national data. Of 13 studies examining pre-pregnancy obesity and antenatal depression, 9 found a higher risk or higher levels of antenatal depression among women with obesity relative to normal weight (6 PS, 3 CS), while 4 studies found no association (2 PS, 2 CS). Of four studies examining pre-pregnancy obesity and postnatal depression, two studies found a positive association (two PS), one study (CS) reported different findings for different obesity classes, and one study found none (PS). The findings suggest that women with obesity are especially vulnerable to antenatal depression. There is a need to develop appropriate screening routines and targeted interventions to mitigate negative health consequences for the mother and the child. Research addressing the association between obesity and postnatal depression is too limited to draw solid conclusions. Results are mainly based on selective samples, and there is a need for further high-quality prospective studies examining the association between pre-pregnancy obesity and antenatal and postnatal depression.

Objective: Group health education is an important aspect of medical rehabilitation. While interaction and active involvement are important characteristics of group health education, little is known about patients’ understanding of their role in this form of education. This study explored patients’ understanding of their role in group health education as part of inpatient rehabilitation. Design: Qualitative, in-depth study. Setting: Six orthopaedic rehabilitation facilities in Germany. Methods: A total of 30 patients participated in six focus groups, and data were analysed using interpretative phenomenological analysis. Results: Findings reveal a complex picture concerning patient role both during and after group health education. Participants expected that patients should fulfil an active patient role and be good patients, but also said that some patients did not always comply with these expectations. Participants perceived that personal, group health education–related and environmental factors can affect the fulfilment of their role. Conclusion: Group health education should not be seen in isolation but in the context of the complex network of personal, group health education–related and environmental factors. Engagement with these factors can contribute to patients’ fulfilment of an active patient role and sustainable success after rehabilitation.

Ziel des Artikels: Ziel ist es, die Entwicklung, die Manualisierung und die Ergebnisse der formativen Evaluation einer patientenorientierten Schulung zur Forderung der Gesundheitskompetenz chronisch Kranker („Aktiv in der Reha“) darzustellen. Methodik: Auf Basis von 17 Fokusgruppen wurden die Themen fur die Schulung abgeleitet. Zur Validierung der Inhalte wurde ein Expertentreffen durchgefuhrt. Die formative Evaluation erfolgte auf Basis eines Fragebogens (Nmax=295 Patienten und Nmax=39 Schulungsleiter). Ergebnisse: Die Schulung beinhaltet 4 Module mit 3 zentralen Themen (bio-psycho-soziales Krankheitsmodell, Reha-Ziele, Kommunikationskompetenzen). Die Bewertungen der einzelnen Module liegen im guten bis sehr guten Bereich. Aus der Analyse der Freitexte und einer Nachbefragung der Schulungsleiter konnten hilfreiche Hinweise fur die Verbesserung der Schulung abgeleitet werden. Schlussfolgerung: Die Ergebnisse zur formativen Evaluation zeigen, dass die Schulung bei Pa­tienten und Schulungsleitern auf Bedarf trifft und akzeptiert wird.

Bariatric surgery is an effective method for treating morbid obesity and improving patientsʼ health-related quality of life (HRQoL). As research on predictors that contribute to the amelioration of HRQoL is sparse, our prospective study was conducted to examine the predictive value of demographic, psychological and physiological variables on physical and mental HRQoL 6 and 12 months after surgery. We surveyed 154 participants who had undergone either a laparoscopic Roux-en-Y gastric bypass (LRYGB) or a laparoscopic sleeve gastrectomy (LSG). Prior to surgery and both 6 and 12 months after the procedure, patients completed questionnaires concerning their demographic data, height and weight, co-morbid conditions, HRQoL (Short Form Health Survey-12), depression severity (Beck Depression Inventory-II), and eating psychopathology (Eating Disorder Examination-Questionnaire). Multiple linear regression analyses were conducted to detect predictors of physical and mental HRQoL 6 and 12 months post-operation. The predictors included within the models explained 50 to 58% of the variance of post-operative physical and mental HRQoL, respectively. Higher baseline depression severity was associated with reduced HRQoL after surgery, whereas changes from pre- to post-surgery in BDI-II scores positively predicted HRQoL values, especially mental HRQoL. The persistence of somatic co-morbid disorders had a negative effect on physical HRQoL. Depression severity before surgery and changes in depression scores were found to be major predictors of HRQoL after bariatric surgery. Therefore, we recommend screening patients regularly for depression both before and after bariatric surgery and offering them adequate psychotherapeutic and/or psychopharmacologic support.

It was our aim to develop a questionnaire for patients with chronic musculoskeletal diseases to self-report their health education literacy, to analyse the psychometric properties of the instrument and to test hypotheses concerning sociodemographic predictors of health education literacy. A total of 577 patients with chronic back pain or osteoarthritis who underwent inpatient rehabilitation were surveyed. The resulting 'HELP questionnaire' (health education literacy of patients with chronic musculoskeletal diseases) consists of 18 items and three scales (comprehension of medical information, applying medical information, communicative competence in provider interactions). The instrument's psychometric properties are good (Cronbach's alpha between 0.88 and 0.95, unidimensionality and Rasch model fit established). Our sample's average level of self-reported health education literacy is quite high. However, 20-30% of the patients admitted to having difficulty understanding important aspects of health education programmes (i.e. comprehending what medical information means in relation to their disease). The variance explained by sociodemographic and basic medical variables is small (4-8%). Greater effort is required to make health education programmes easier to understand. There is a need for more research on interindividual variability of complex aspects of health literacy.

OBJECTIVE In the context of an increasing patient orientation in health care, surveying patients on the success of treatment has become highly relevant. The objective of the study was to develop and test an instrument for surveying the patients' perceptions of the participation relevance of changes in health status after inpatient medical rehabilitation with respect to various areas of life for 3 diagnoses: breast cancer, chronic ischemic heart disease, and chronic back pain. METHODS The instrument refers to certain disease-specific areas of health (e. g., mobility) with regard to which the patients are asked whether they perceived an improvement and if so, what improvement in participation had ensued as a result. A questionnaire study (measuring time points: end of rehab and 6 months after the end of rehab) was conducted in 3 samples (breast cancer: n=297, chronic ischemic heart disease: n=295, chronic back pain: n=186) to test the methodology. The share of missing values and undesirable ceiling/floor effects were assessed to analyze the distribution characteristics. In a partial sub-sample, a third measuring time point was introduced approx. 10 days after the second measuring time point, and the retest reliability of the assessment of participation relevance is determined using the ICC. We also present descriptive results relative to the participation relevance from the patient perspective. RESULTS The instrument shows good distribution characteristics for the items. Regarding retest reliability, there were satisfactory values for all diagnoses in all areas of health. The descriptive analyses showed that patients who perceived a noticeable improvement in their health status at the end of rehabilitation or 6 months after inpatient rehab generally assessed the participation relevance of this improvement in health to be "moderate" to "strong". DISCUSSION The concept of assessing the participation relevance from the patient perspective is a satisfactorily reliable construct. By including the subjective significance of treatment success it takes into account the concept of clinical significance from the patient's perspective, a concept which has thus far been considered only insufficiently. Results show that patients ascribe the health improvements achieved by rehabilitation a noticeable relevance for their participation.

Background Obesity and anxiety during the perinatal period are common and associated with poor health outcomes for the mother and the child. Despite the well-documented health risks of both pregnancy obesity and anxiety, associations between the two have rarely been explored. With this review we aim to provide a systematic overview of the current state of evidence concerning associations between ante- and postnatal anxiety and pregnancy obesity, excessive gestational weight gain, and postpartum weight retention. Methods We conducted a systematic literature search in PubMed, Web of Science, and PsychINFO. Results 13 Records matched our inclusion criteria. Five out of seven studies focusing on pregnancy obesity and anxiety suggest a positive association with ante- or postnatal anxiety. Surprisingly, no study examined anxiety disorders according to DSM and it remains unknown whether anxiety symptomatology reaches clinical relevance. Results from a small number of life-style intervention studies ( n =3) suggest that interventions could benefit from a stronger focus on mental health. There were not enough studies on associations between excessive gestational weight gain ( n =2) or postpartum weight retention ( n =3) and anxiety making it difficult to draw conclusions about possible associations. Limitation The number of included studies is rather small and studies were included irrespective of the study quality which might limit the generalizability of the results. Conclusions The majority of the included studies suggest that obese pregnant women might constitute a subgroup that is especially vulnerable for comorbid anxiety and in need of targeted psychological support. However, further high-quality studies, particularly including anxiety disorders, are needed.

Pre-pregnancy overweight and obesity is associated with poor health outcomes for the mother and the child. General population studies suggest that childhood maltreatment is associated with obesity in adulthood. The aim of our study was to examine the association between pre-pregnancy overweight and obesity and a history of childhood abuse or neglect including different stages of severity of abuse and neglect. Three hundred twenty-six normal weight, overweight, or obese pregnant women reported demographic data, height and weight, and general psychological distress at 18-22 weeks of gestation. Childhood maltreatment was assessed using the Childhood Trauma Questionnaire. Associations were examined using logistic regression analyses and a reference group of normal weight women. Fifty percent reported a history of abuse or neglect. After adjusting for age, education, income, marital status, and the number of previous children, pre-pregnancy overweight and obesity were strongly associated with severe physical abuse (overweight: OR = 8.33, 95% CI 1.48-47.03; obesity: OR = 6.31, 95% CI 1.06-37.60). Women with severe physical neglect (OR = 4.25, 95% CI 1.23-14.74) were at increased risk of pregnancy overweight. We found a dose-response relationship between physical abuse and pre-pregnancy overweight and obesity. Whereas other studies report an association between childhood maltreatment and pre-pregnancy obesity, this is the first study that found an association between childhood maltreatment and pre-pregnancy overweight. Considering the severe health risks of pre-pregnancy overweight and obesity and the long-term consequences of childhood maltreatment, affected women constitute a subgroup with special needs in prenatal care. Further research is needed to improve the understanding of the underlying mechanisms.

Study aim was to translate the PROMIS(®) pain interference (PI) item bank (41 items) into German, test its psychometric properties in patients with chronic low back pain and develop static subforms.We surveyed N = 262 patients undergoing rehabilitation who were asked to fill out questionnaires at the beginning and 2 weeks after the end of rehabilitation, applying the Oswestry Disability Index (ODI) and Pain Disability Index (PDI) in addition to the PROMIS(®) PI items. For psychometric testing, a 1-parameter item response theory (IRT) model was used. Exploratory and confirmatory factor analyses as well as reliability and construct validity analyses were conducted.The assumptions regarding IRT scaling of the translated PROMIS(®) PI item bank as a whole were not confirmed. However, we succeeded in devising three static subforms (PI-G scales: PI mental 13 items, PI functional 11 items, PI physical 4 items), revealing good psychometric properties.The PI-G scales in their static form can be recommended for use in German-speaking countries. Their strengths versus the ODI and PDI are that pain interference is assessed in a differentiated manner and that several psychometric values are somewhat better than those associated with the ODI and PDI (distribution properties, IRT model fit, reliability). To develop an IRT-scaled item bank of the German translations of the PROMIS(®) PI items, it would be useful to have additional studies (e.g., with larger sample sizes and using a 2-parameter IRT model).

Objective The objective was to develop a comprehensive questionnaire for measuring the patient-perceived comprehensibility of health education programs (COHEP questionnaire). According to a conceptual model outlined in the article, comprehensibility is considered a context factor of patient health literacy. Methods A questionnaire study was carried out on N = 577 patients with chronic musculoskeletal diseases. During inpatient rehabilitation, patients participated in standardized, interactive group education programs conducted by clinic personnel. Factorial structure, unidimensionality, reliability, fit to the Rasch model, and construct validity were tested. Results The COHEP consists of 30 items and 4 scales (comprehension-fostering behavior of program trainers, transferability to everyday life, comprehensibility of medical information, amount of information). All scales are reliable, unidimensional, and meet the requirements of the Rasch model. In addition, there are initial indications of validity. The descriptive results show that the overall rating of the comprehensibility of patient education programs in the German rehabilitation system is good, but that there are clear differences between centers. Conclusion The COHEP can be used to evaluate health education programs, since it measures an important proximal outcome. Practice implications An analysis of patient-perceived comprehensibility can help providers adapt education sessions better to the health literacy of patients.

The objective of this study was to examine whether aspects of the patient-physician relationship for breast cancer patients have an influence on the change in health-related quality of life (HRQOL) after inpatient rehabilitation.N = 329 breast cancer patients undergoing inpatient rehabilitation in Germany were surveyed using questionnaires at the beginning of rehabilitation, end of rehabilitation, and 6 months after rehabilitation. Multiple imputations and multilevel models of change were used in the data analyses.Even after comprehensive adjustment for sociodemographic, medical, psychological variables, and center effects, aspects of the physician-patient relationship were statistically and clinically relevant predictors of HRQOL after rehabilitation. Satisfaction with physician's care appears to have a rather short-term effect, but the effect of promoting patient participation can still be partially determined 6 months after rehabilitation. Other important predictors of HRQOL improvement are optimism, higher level of education, higher income, living with a partner, and the ability to work.By taking into consideration the patient's communication and participation needs, physicians can contribute to an improved HRQOL after rehabilitation. The high predictive power of socioeconomic factors shows that rehabilitation care can be more effective if it accounts for the specific situation of socially disadvantaged individuals.

The aim of this study was to test the congruence of patients' health valuations and physicians' treatment goals for the rehabilitation of chronically ill patients. In addition, patient characteristics associated with greater or less congruence were to be determined. In a questionnaire study, patients' health valuations and physicians' goals were assessed in three chronic conditions [breast cancer (BC), chronic ischemic heart disease (CIHD), and chronic back pain (CBP)] using a ranking method. Sociodemographic variables and health-related quality of life were assessed as patient-related factors that influence congruence. Congruence was determined at the group (Spearman's ρ) and individual levels (percentage of congruence). Patient-related influencing factors were calculated after a simple imputation using multiple logistic regression analysis. At the group level, there were often only low correlations. The mean percentage of congruence was 34.7% (BC), 48.5% (CIHD), and 31.9% (CBP). Patients with BC or CIHD who have a higher level of education showed greater congruence. Our results indicate some high discrepancy rates between physicians' treatment goals and patients' health valuations. It is possible that patients have preferences that do not correspond well with realistic rehabilitation goals or that physicians do not take patients' individual health valuations sufficiently into consideration when setting goals.

To examine the extent and type of influence of response shift (RS) (reconceptualization, reprioritization, recalibration) on the assessment of changes in health-related quality of life (HRQoL) after the inpatient rehabilitation of patients with chronic back pain and chronic ischaemic heart disease.RS was assessed using the then-test and structural equation modelling (SEM) approaches. HRQoL was recorded in a questionnaire study at the start and end of rehabilitation using disease-specific instruments. Global items were also developed to collect data on HRQoL at the start and end of rehabilitation, as well as for the retrospective evaluation of HRQoL at the beginning of rehabilitation via the then-test.There are small recalibration effects in the then-test in both diseases in nearly every item which may underestimate the actual effects of change. Using the SEM approach, uniform and non-uniform recalibration effects appear in a few of the scales that cause true change scores to be under- and over-estimated.RS reflects a phenomenon that should be included when assessing HRQoL to allow a more valid interpretation of treatment effects. The results of SEM approach, however, suggest that RS does not lead to fundamentally different results in rehabilitation effects.