Search

In this paper, a non-mechanical axial zoom scanning method based on a phase only liquid crystal spatial light modulator is proposed. This novel method is to overcome the measurement error caused by moving mechanical parts in the axial mechanical scanning methods in the confocal microscopy system. The modulation on the incident wave front is completed by a spatial light modulator, which provides this scanning method some outstanding advantages including the flexibility of control and the absence of moving mechanical parts, especially suitable for the fixed sample imaging occasions. By simulating the multiple Fresnel lens with LCSLM to generate controllable multi-focal points and thus realizing this method of axial multi-focus scanning to enhance the axial scanning efficiency and the range. Simulations and experiments on the axial scanning features of the axial multi-focus zoom scanning method are carried out. Results of simulations and experiments indicate that non-mechanical axial zoom scanning can be realized with the use of a spatial light modulator in the confocal microscopy system.

Although cardiac hypertrophy is widely recognized as a risk factor that leads to cardiac dysfunction and, ultimately, heart failure, the complex mechanisms underlying cardiac hypertrophy remain incompletely characterized. The nuclear receptor peroxisome proliferator-activated receptor δ (PPARδ) is involved in the regulation of cardiac lipid metabolism. Here, we describe a novel PPARδ-dependent molecular cascade involving microRNA-29a (miR-29a) and atrial natriuretic factor (ANF), which is reactivated in cardiac hypertrophy. In addition, we identify a novel role of miR-29a, in which it has a cardioprotective function in isoproterenol hydrochloride-induced cardiac hypertrophy by targeting PPARδ and downregulating ANF. Finally, we provide evidence that miR-29a reduces the isoproterenol hydrochloride-induced cardiac hypertrophy response, thereby underlining the potential clinical relevance of miR-29a in which it may serve as a potent therapeutic target for heart hypertrophy treatment.

Computer Aided Design, referred to as CAD combining with each other modern project management theory currently is the mainstream of project management used in the construction industry. But with the continuous improvement of the complexity of the architectural design the drawbacks of the mainstream construction management has become more and more apparent. Under the circumstances, proposing the theory of BIM, shorter form of Building Information Modeling, opened up a new path for the project management informatization to continue developing. In this paper, based on the current BIM development trends and our own construction industry development laws, through a brief review of the development of CAD technology and BIM technology development history, put forward which construction industry issues the BIM can solve. And then based on comparing the research status in home and abroad and analysising the existing questions to develop BIM, improve the traditional project management model and build the proper 3D BIM project management processes.

Aiming at the shortcomings of mechanical scanning methods, non-mechanical scanning method is proposed. A zoom illuminating lens which has multiple focal points is realized by introducing Liquid Crystal Spatial Light Modulator (LC-SLM) into the confocal illumination light path, and thus it produces the multifocal zoom lens axially. The axial optical sectioning in a conventional confocal microscope is achieved by beam scanning rather than mechanically moving the objective lens, which enhances the capacity of chromatography and improves the scanning speed with greater accuracy. To generate and shift the multiple axial focal points, the modulation phase bitmaps of LC-SLM is changed. Simulation results further show that multifocal axial confocal beam scanning replacing mechanical scanning can therefore be implemented.