1. Bioresorbable Scaffolds in Percutaneous Coronary Intervention: Facing Old Problems, Raising New Hopes
- Author
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Giulio Rodinò, Yuji Matsuda, Giulia Masiero, Mauro Boiago, and Giuseppe Tarantini
- Subjects
Bioresorbable scaffold ,medicine.medical_specialty ,Time Factors ,Stent thrombosis ,medicine.medical_treatment ,Vascular restoration therapy ,Thrombogenicity ,030204 cardiovascular system & hematology ,Prosthesis Design ,Coronary artery disease ,Stent ,03 medical and health sciences ,Percutaneous Coronary Intervention ,0302 clinical medicine ,Absorbable Implants ,Mechanical strength ,medicine ,Humans ,030212 general & internal medicine ,Pump thrombosis ,Intensive care medicine ,Bioresorbable vascular scaffold ,business.industry ,Percutaneous coronary intervention ,Drug-Eluting Stents ,Treatment Outcome ,Cardiology and Cardiovascular Medicine ,business - Abstract
In this review, we discuss about the reasons behind the failure of the Absorb bioresorbable vascular scaffold (BVS) device and about the challenges the future holds for the next generation of the bioresorbable scaffold (BRS) technology. Absorb BVS was burdened by intrinsic structural limitations which resulted in augmented rates of device thrombosis and clinical adverse events compared to current-generation metallic stent. Nevertheless, new generation devices with novel design and materials are in development. Second generation BRS have enhanced mechanical strength, smaller footprints, less thrombogenicity and modified bioresorption. These features, paired with proper patient and lesion selection and optimal “user-friendly” implant techniques, could possibly overcome the previous BRS generation limitations, rekindling physicians, and industry interest on this promising technology.
- Published
- 2021