1. Prevalence of relative systemic hypertension in adults with sickle cell disease in Ghana
- Author
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Solomon F. Ofori-Acquah, Amma A. Benneh-Akwasi Kuma, Mary Akua Ampomah, Fredericka Sey, Amma Owusu-Ansah, Edeghonghon Olayemi, and Mehdi Nouraie
- Subjects
Male ,Pulmonology ,lcsh:Medicine ,Blood Pressure ,Disease ,030204 cardiovascular system & hematology ,Ghana ,Vascular Medicine ,Infographics ,Biochemistry ,Geographical Locations ,0302 clinical medicine ,Prevalence ,Medicine and Health Sciences ,Medicine ,lcsh:Science ,Stroke ,Aged, 80 and over ,education.field_of_study ,Pulmonary Hypertension ,Multidisciplinary ,Hematology ,Middle Aged ,Charts ,3. Good health ,Pulse pressure ,Neurology ,Genetic Diseases ,030220 oncology & carcinogenesis ,Hypertension ,Female ,medicine.symptom ,Research Article ,Adult ,Computer and Information Sciences ,medicine.medical_specialty ,Adolescent ,Anemia ,Cerebrovascular Diseases ,Population ,Anemia, Sickle Cell ,Young Adult ,03 medical and health sciences ,Autosomal Recessive Diseases ,Internal medicine ,Humans ,Hemoglobin ,education ,Aged ,Clinical Genetics ,Sickle Cell Disease ,business.industry ,Data Visualization ,lcsh:R ,Organ dysfunction ,Biology and Life Sciences ,Proteins ,medicine.disease ,Pulmonary hypertension ,Hemoglobinopathies ,Blood pressure ,People and Places ,Africa ,lcsh:Q ,business - Abstract
Individuals with sickle cell disease particularly with the homozygous (SS) genotype historically have relatively low blood pressure. Nonetheless, they develop vasculopathy-associated organ dysfunction and the risk of organ dysfunction increases at blood pressures that are normal in the general population. This phenomenon is termed relative systemic hypertension (RSH) with a systolic blood pressure range of 120–139 mmHg, and diastolic blood pressure range of 70–89 mmHg. The significance of RSH lies in its association with renal insufficiency, pulmonary hypertension, stroke and propensity to progress to systemic hypertension. We conducted a retrospective chart review of 1,000 adults with sickle cell disease at the Ghana Institute of Clinical Genetics, to determine the prevalence of RSH in sickle cell disease in Ghana and associated complications. We found a high prevalence of RSH and hypertension with a relatively low frequency of renal insufficiency. Pulse pressure, a predictor of mortality, was higher in males of all ages. We anticipate that providing an estimate of the burden of RSH will heighten its recognition and clinical management among health care providers.
- Published
- 2018