Search

The molecular pathways which promote lung cancer cell features have been broadly explored, leading to significant improvement in prognostic and diagnostic strategies. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have dramatically altered the treatment approach for patients with metastatic non-small cell lung cancer (NSCLC). Latest investigations by using next-generation sequencing (NGS) have shown that other oncogenic driver mutations, believed mutually exclusive for decades, could coexist in EGFR-mutated NSCLC patients. However, the exact clinical and pathological role of concomitant genomic aberrations needs to be investigated. In this systematic review, we aimed to summarize the recent data on the oncogenic role of concurrent genomic alterations, by specifically evaluating the characteristics, the pathological significance, and their potential impact on the treatment approach.

Purpose: Cloud computing has opened new opportunities in disastrous natural early warning. The scientific community has recognized the significance of the geo-analytic approach in complex decision-making processes for critical situations due to natural events such as coastal erosion and landslides. The paper describes the progress in the development of ITC dissemination systems for the population to promote the preparedness toward the coastal risk. Methodology: To achieve these goals an information system based on an Open Source Cloud Computing platform following a PaaS (Platform as a Service) and SaaS (Software as a Service) approaches has been used. Main Findings: The southern coast of Sicily (Italy) and the islands of the archipelagos of Malta are highly exposed to risks coming from the sea. Such coasts are subjected to fast erosion due to natural and anthropic causes which involve the failure of cliffs, the triggering of localized erosions, and the possibility of flooding. Implications/Applications: The research effort aims to build an interconnected framework through the implementation of smart technology, which involves surveillance, early warning, and reduction of coastal threats, with a specific goal to educate citizens regarding flood hazards, coastal waters, and degradation, cliff collapses and safety steps. Novelty/Originality of this study: The study expresses a different perspective on cloud computing to prevent the effects of disastrous natural events and to provide indications of areas susceptible to risk.

Victimization has been widely demonstrated to have negative consequences in minors. Most crimes against children go unreported and victims tend to reach adulthood without receiving any of the available specialized support. Studies have highlighted the unique role of school workers in early detection and reporting of possible cases of victimization, and have also found high rates of underreporting by school staff. The present study analyzes the underreporting of child and youth victimization suspicions among school staff and aims to identify variables related to its detection and reporting. One hundred and eighty-four school staff members (83.7% females, M = 42.6 years old, SD = 11.7) from 17 different schools completed a self-administered questionnaire designed to record their knowledge and experience regarding the detection and reporting of potential victimization cases. Over 74% of the school workers had suspected at least one situation of victimization during their careers, but only 27% had actually reported these concerns. Higher rates of reporting were significantly associated with male gender, more years of experience, and awareness of five common misconceptions. Reporting behavior could be predicted by gender, years of experience and two statements assessing respondents’ knowledge of victimization. In order to increase early reporting of possible cases of victimization, it is necessary to overcome certain misconceptions, raise awareness among school staff, design new training programs or interventions, and adapt the school dynamics in the light of these findings.

Unmet medical needs are a priority for organizations such as the WHO and major public-private initiatives, such as Innovative Medicines Initiative, were established to speed up the development of better and safer medicines for patients. To assist such projects, the EMA in its 'Road Map to 2015' considered the mapping of unmet medical needs as a priority. This study has identified medical conditions for which the EMA could not identify developments in the pharmaceutical pipelines, that is, 'white spots'. Our analysis was made using external data sources as well as mining data of the EMA. The main areas for white spots were oncology, infectious diseases and certain psychiatric conditions. According to our data and a review of literature, in a number of these white spots, diagnostic tools may even be missing. The identification of those conditions will benefit stakeholders, including regulators, research funding bodies and patients' organizations.