1. Preliminary studies of acute and sub-chronic toxicity of the aqueous extract of Guibourtia tessmannii (Harms) J. Leonard stem barks (Caesalpiniaceae) in mice and rats
- Author
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Sylvin Ouedraogo, A. Traoré, Raissa Reine Aworet Samseny, Alain Souza, Alfred S. Traore, Noreen Orianna Koumba Madingou, and Marlaine Boukandou Mounanga
- Subjects
lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,Pharmacology ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Median lethal dose ,03 medical and health sciences ,0302 clinical medicine ,Stem barks ,Medicine ,lcsh:QH301-705.5 ,Vital organ ,Guibourtia tessmannii ,Aqueous extract ,Low toxicity ,Toxicity ,business.industry ,Acute toxicity ,0104 chemical sciences ,Subchronic toxicity ,Plant extract ,010404 medicinal & biomolecular chemistry ,lcsh:Biology (General) ,030220 oncology & carcinogenesis ,Herbal medicine ,business - Abstract
Objective To investigate the toxicity of aqueous extract of Guibourtia tessmannii (Harms) J. Leonard ( G. tessmannii ) and evaluate its safety. Methods NMRI mice were used to determine the acute toxicity of G. tessmannii . Increasing concentrations of the plant extracts were administered intraperitoneally or by force-feeding. General behavior and death were monitored and recorded daily for 7 days. In order to determine the sub-acute toxicity of the extract, several doses were administered by oral gavage daily for 28 days in adult Wistar rats. Different parameters were assessed including body weight, food and water intake, biochemical parameters and several vital organ weights. Results LD 50 of 328.78 mg/kg was obtained by i.p. route and more than 5 000 mg/kg was obtained in acute toxicity by oral route. In sub-acute toxicity, no significant alteration was observed in body weight or vital organs, food and water intake, and biochemical parameters. Conclusions The results showed that the aqueous extract of G. tessmannii has low toxicity intraperitoneally and no sub-acute toxicity via oral intake.
- Published
- 2016
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