1. Neonatal Vitamin D Levels in Relation to Risk of Overweight at 7 Years in the Danish D-Tect Case-Cohort Study
- Author
-
Camilla B. Jensen, Berit L. Heitmann, Thorkild I. A. Sørensen, and Marika Lundqvist
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Percentile ,Health (social science) ,Offspring ,Epidemiology ,Denmark ,030209 endocrinology & metabolism ,lcsh:TX341-641 ,Overweight ,Body Mass Index ,Childhood overweight ,Cohort Studies ,03 medical and health sciences ,BMI ,0302 clinical medicine ,Dried blood spots ,Pregnancy ,Risk Factors ,Physiology (medical) ,Vitamin D and neurology ,Humans ,Medicine ,030212 general & internal medicine ,Vitamin D ,Child ,lcsh:RC620-627 ,Vitamin D, pregnancy ,Calcifediol ,business.industry ,Infant, Newborn ,Vitamin D Deficiency ,medicine.disease ,Vitamin D,pregnancy ,lcsh:Nutritional diseases. Deficiency diseases ,Case-cohort study ,Cohort ,Female ,Original Article ,Seasons ,medicine.symptom ,business ,lcsh:Nutrition. Foods and food supply ,Demography ,Cohort study - Abstract
Background: Vitamin D level in pregnancy may be associated with risk of overweight in the offspring later in life. Methods: In a case-cohort study based on Danish biobanks and registers we examined the association between 25-hydroxy-vitamin D (25(OH)D) level at birth and overweight at 7 years. Cases of overweight (n = 871) were randomly selected among 7-year-old children from the Copenhagen School Health Records Register (CSHRR) with a BMI above the 90th percentile. The cohort (n = 1,311) was a random sample selected among all Danish children born during the same period. Neonatal 25(OH)D was measured in dried blood spots. Results: 25(OH)D3 exhibited the expected seasonal variation. Median level of 25(OH)D3 was 20.6 (11.9-33.3) nmol/l in the overweight group and 23.4 (13.5-34.3) nmol/l in the cohort. We found no association between neonatal 25(OH)D3 level and risk of overweight at age 7 years, neither in the crude model (OR (CI) 1.00 (0.99; 1.00)) nor in a model adjusted for maternal ethnicity, educational level, civil status, parity, season and year of birth, and offspring ponderal index (OR (CI) 1.00 (0.99; 1.01)). Conclusion: Risk of overweight at 7 years of age was not associated with vitamin D level at birth.
- Published
- 2017