1. Ventilation With or Without Endotracheal Tube Leak in Prolonged Neonatal Asphyxia
- Author
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Apostolos Papalois, Afrodite Aggelina, Alexandros Douvanas, Maria Kalafati, Christina Koulouglioti, Eleni Tamvaki, Alexandra Nieri, and Elizabeth Papathanassoglou
- Subjects
Mean arterial pressure ,Resuscitation ,medicine.medical_treatment ,swine models ,Return of spontaneous circulation ,Pediatrics ,neonatal resuscitation ,Anesthesiology ,medicine ,return of spontaneous circulation ,birth respiratory support ,perinatal asphyxia ,Mechanical ventilation ,Asphyxia ,business.industry ,General Engineering ,Central venous pressure ,neonatal asphyxia ,medicine.disease ,Perinatal asphyxia ,Anesthesia ,Emergency Medicine ,newborn piglet model ,medicine.symptom ,endotracheal tube leakage ,business ,Neonatal resuscitation - Abstract
Background Severe and prolonged asphyxia can result in either intrauterine fetal death and stillbirth or multiorgan failure in surviving neonates. Establishing effective ventilation is the primary aim of resuscitation in newborns with asphyxia. The objective of this study was to compare the outcome of resuscitation by applying an endotracheal tube (ETT) with less, an ETT with moderate, and an ETT with high leakage during mechanical ventilation in swine neonates after prolonged perinatal asphyxia. Materials and methods A prospective, randomized controlled laboratory study was performed. Thirty Landrace/large white pigs, aged one to four days and weighted 1.754±218 gr, were randomly allocated into three groups depending on the ETT size: Group C (less leak: ETT no 4.0, n=10); Group A (high leak: ETT no 3.0, n=10); and Group B (moderate leak: ETT no 3.5, n=10). Mechanical asphyxia was performed until their heart rate was less than 60 bpm or their mean arterial pressure was below 15 mmHg. All animals with return of spontaneous circulation (ROSC) were monitored for four hours for their hemodynamic parameters, arterial oxygen saturation, and lactate acid levels. Results We demonstrate that 70% of the surviving animals were ventilated with an ETT with a leak (no. 3.5 and 3). A statistically significant difference was noted in PO2 (p=0.032) between Group B (126.4±53.4 mmHg) compared to Group A (72.28±29.18 mmHg) and Group C (94.28±20.46 mmHg) as well as in the right atrial pressure (p
- Published
- 2021