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ZusammenfassungInfantile Hämangiome im Lid- und Orbitabereich können trotz ihres selbstlimitierenden natürlichen Verlaufs zu funktionellen Defiziten infolge einer Amblyopie oder Optikuskompression führen oder ein ästhetisch störendes Erscheinungsbild entwickeln und bedürfen dann einer Therapie.Seit der „zufälligen” Entdeckung des Effektes von Propranolol auf infantile Hämangiome im Jahr 2008 wird diese Substanz zur Behandlung komplizierter Hämangiome eingesetzt, die ansonsten den Einsatz von Kortikosteroiden, Laser oder operativen Verfahren erfordert hätten. Propranolol systemisch ist derzeit bei komplizierten Hämangiomen der Lider und Orbita aufgrund des raschen und komplikationsarmen Therapieeffektes Therapie der ersten Wahl.Dargestellt werden Pathogenese, Klassifikation, Indikation zur Therapie, Therapieoptionen sowie deren Effektivität für infantile Hämangiome im Lid- und Orbitabereich.Weitere klinische Studien zur Optimierung von Dosierung, Behandlungsdauer und Art der Anwendung von Propranolol (lokal oder systemisch) sind jedoch weiterhin erforderlich, um den Regressionseffekt und die Regressionsrate weiter zu verbessern.

In spite of the self-limiting natural course of infantile haemangiomas of the eyelids and orbit, the effects of amblyopia, compression of the optic nerve, and impairment of the aesthetic appearance may develop. Since the serendipitous discovery of the effects of propranolol, a non-selective beta-blocker, on infantile haemangioma in 2008, it has largely replaced the former standard treatments with corticosteroids, laser or surgical procedures. This review discusses the pathogenesis, classification, indication for treatment, and treatment options for infantile haemangiomas. In addition, the results of patients with infantile haemangiomas of the eyelids and orbit treated with systemic propranolol are shown. With additional confirmation of data, including a positive effect-risk-analysis, propranolol will potentially replace high-dose corticosteroids and surgery in the treatment of infantile haemangiomas in the eyelids and orbit. Further clinical studies are necessary to optimise the dosage, treatment period, and application modalities (oral or topical). In the future, propranolol accompanied with paediatric-cardiological monitoring should emerge as the first-line therapy for problematic infantile haemangiomas.

In the past planar superconductive undulators have been successfully developed and tested with beam. They produce linearly polarized light (X-rays) and allow to tune the emitted wavelength electrically. In this paper a novel type of superconductive undulators is introduced which allows to tune electrically in addition to the wavelength the polarization direction. A short prototype was built and tested in a LHe bath.

Following the successful performance of a beam test with a superconductive undulator at the synchrotron light source ANKA there are plans to equip most of the straight sections with superconductive undulators. In this paper the first results of the measurements are presented and future plans are summarized.

The first beam measurements with a cold-bore superconducting in-vacuum undulator in a storage ring are reported. Undulators are x-ray generators in light sources. The physical limitations of these devices limit the intensity and the brilliance of the x-ray beam. At present the undulators are made from permanent magnets. It was shown in earlier papers that at low electron beam intensities superconductive wires in the vacuum beam pipe can overcome the limitations inherent to permanent magnet undulators. It was argued that the use of these novel devices in light sources with high beam currents may be limited by the extreme anomalous skin effect regime in Cu at 4.2 K, which has so far undergone very little investigation, and the power deposited by the infrared part of the synchrotron radiation. The purpose of this paper is to present measurements of these effects at the synchrotron light source ANKA with stored currents up to 200 mA.

Superconductive undulators with a small period length are a novel tool in generating X-ray beams with high brlliance. The concept and the first prototype for a s storage ring was developed for ANKA, a 2.5 GeV synchrotron light source in Karlsruhe, Germany.