Search

Purpose: Fatigue after treatment for breast cancer is common, but is also prevalent in people with chronic diseases such as heart failure, diabetes, and depression etc. The primary objective was to compare the level of fatigue between BC patients one year after end of treatment with data from a representative survey of the Norwegian population (GenPop). Secondary aim was to explore the association between chronic conditions and fatigue and in both samples. Design and Method: 245 patients treated with chemo –and/or radiotherapy after surgery, were assessed one year after treatment. Comorbidity was recorded by clinical examinations in patients and by self-report in the GenPop (N = 652). Fatigue was measured by the 3-item subscale of the EORTC QLQ-C30, with higher scores on the 0–100 scale implying more fatigue. Analysis of covariance was applied to compare age-adjusted mean scores between groups. Results: Mean age was 58 (9) years in patients and 52 (14) years in GenPop. 23% of patients and 32% of GenPop had one or more of the following conditions; cardiovascular- or pulmonary disease, diabetes or depression. No significant differences were found in fatigue between BC patients and GenPop (mean score 26.7 vs. 29.7). Comorbidity was the greatest determinant of increased fatigue, regardless of BC treatment. Patients with comorbidity were significantly more fatigued than those without comorbidity (mean difference 10.4), as found in the GenPop (mean difference 13.3). Conclusion: Similar fatigue levels in BC patients and GenPop one year after treatment is promising, but longer follow-up is needed. Comorbidity conditions should always be assessed when evaluating fatigue and other patient related outcomes. Prevention or treatment of common chronic conditions might be considered in rehabilitation programs to reduce fatigue in cancer survivors. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P6-09-03.

Das EORTC QLQ-LC13 war das erste Lebensqualitatsfragebogen-Modul, das zusammen mit dem Kernfragebogen QLQ-C30 entwickelt und 1994 veroffentlicht wurde. Seit der Entwicklung des QLQ-LC13 Moduls haben sich einige neue Erkenntnisse in der Epidemiologie und erhebliche Fortschritte in der Diagnostik und Therapie des Lungenkarzinoms ergeben. Das uberarbeitete Fragebogenmodul soll im Kontext aller aktuell moglichen diagnostischen und therapeutischen Optionen entstehen, fur alle unterschiedlichen Lungenneoplasien (kleinzelliges Lungenkarzinom – SCLC, nicht kleinzelliges Lungenkarzinom – NSCLC) in metastasierten und nicht metastasierten Stadien verwendbar sein und generelle Aspekte der Lebensqualitat fur Lungenkarzinompatienten einbeziehen. Methodische Grundlage fur die Uberarbeitung ist das Phase 1–3 Schema gemas dem EORTC Modulentwicklungs-Manual.

Benign small bowel tumors are rare. If those with malignant potential are excluded, a small group of truly benign lesions remains. Fifty-six cases of these small bowel tumors were analyzed for clinical data, pathologic diagnosis, number, size, location, and radiologic appearance. Lesions included lipoma, myoepithelial hamartoma, Peutz-Jeghers hamartoma, neurogenic tumors (including gangliocytic paraganglioma), Brunner's gland abnormalities, and inflammatory fibroid polyp. Location, number, and radiographic morphology can be helpful in reaching a more specific diagnosis. Age of patient and size of tumor may be helpful in the differential diagnosis; however, sex of the patient and clinical symptoms are not.

In a study of 105 gastrointestinal carcinoid tumors, 67% of the rectal carcinoids and 15% of the carcinoids at other gastrointestinal sites were positive, immunohistochemically, for prostatic acid phosphatase activity. These findings are relevant to the differential diagnosis between rectal carcinoids and prostatic carcinoma.

Gastrointestinal teratomas are uncommon, benign neoplasms that occur primarily in children. A retrospective review of five cases (two gastric, one pancreatic, one mesenteric, and one in the lesser omentum) is presented with emphasis on the computed tomographic and ultrasonographic appearances. Principal findings are a well-defined mass with separate cystic and solid components of varying proportions, discrete areas with densities similar to that of fat, or coarse, globular calcifications within the solid component. Recognition of these findings may allow the radiologist to make a correct preoperative diagnosis of teratoma.