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QRS detection is a crucial task for ECG signal analysis, which is the preliminary and essential step to further recognition and diagnosis. This paper proposes a U-Net based method for QRS detection. The method consists of three steps including preprocessing, U-Net model, and density-based spatial clustering of applications with noise(DBSCAN). The normalization is carried out using the Z-score method in preprocessing. In this study, location prediction is conducted by the U-Net model. Subsequently, the U-Net outputs are thresholded and clustered by DBSCAN. Finally, the middle points of the cluster are regards as the R-peak of the QRS complex. We demonstrate that the proposed method achieving high accuracy on ECG signals from the MIT-BIH Arrhythmia Database(MITDB). The experimental results show an average sensitivity of 99.98 %, positive predictivity of 99.95 %, accuracy of 99.93 %, and F1-score of 99.97 %. Compared with other existing methods, the overall performance is comparable and even better in terms of accuracy and F1-score.

The quality traits of horticultural crops, including the accumulation of nutrients and flavor substances, morphology, and texture, affect the palatability and nutritional value. For many years, efforts have been made to improve the quality of horticultural crops. The recent establishment of gene editing technology, with its potential applications in horticultural crops, provides a strategy for achieving this goal in a rapid and efficient manner. Here, we summarize research efforts aimed at improving horticultural crop quality through genome editing. We describe specific genome editing systems that have been used and traits that have been targeted in these efforts. Additionally, we discuss limiting factors and future perspectives of genome editing technology in improving horticultural crop qualities in both research and plant breeding. In summary, genome editing technology is emerging as a powerful tool for efficiently and rapidly improving horticultural crop quality, and we believe that the cautious application of genome editing in horticultural crops will generate new germplasms with improved quality in the near future.

INTRODUCTION To maximize the use of intensive care unit (ICU) re--sources, it is important to estimate the prevalence and risk factors for prolonged ICU unit stay after coronary artery bypass grafting (CABG) surgery. MATERIAL AND METHODS This retrospective cohort study included all patients who underwent primary isolated CABG at Landspitali between 2001 and 2018. Patient information was collected from hospital charts and death registries. Patients who stayed in the ICU for the conventional one night postoperatively were compared with those who needed longer stays in the ICU. Survival rate was estimated with the Kaplan-Meier method. Predictors for prolonged ICU stay were calculated with logistic regression and the outcome used to create a calculator that estimates the probability of prolonged ICU stay. RESULTS Out of 2177 patients, 20% required prolonged ICU stay. Patients with prolonged stay were more frequently female (23% vs 16%, p=0.001), had a higher rate of cardiovascular risk factors and higher EuroSCORE II (4.7 vs. 1.9, p

Background Aidi Injection (ADI), a Chinese herbal preparation with anti-cancer activity, is used for the treatment of hepatocellular carcinoma (HCC). Several clinical studies have shown that co-administration of ADI with doxorubicin (DOX) is associated with reduced toxicity of chemotherapy, enhanced clinical efficacy and improved quality of life for patients. However, limited information is available about the herb-drug interactions between ADI and DOX. The study aimed to investigate the pharmacokinetic mechanism of herb-drug interactions between ADI and DOX in a rat model of HCC. Methods Experimental HCC was induced in rats by oral administration of diethylnitrosamine. The HCC rats were pretreated with ADI (10 mL/kg, intraperitoneal injection) for 14 consecutive days prior to administration of DOX (7 mg/kg, intravenous injection) to investigate pharmacokinetic interactions. Plasma concentrations of DOX and its major metabolite, doxorubicinol (DOXol), were determined using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Results Preadministration of ADI significantly altered the pharmacokinetics of DOX in HCC rats, leading to increased plasma concentrations of both DOX and DOXol. The area under the plasma drug concentration-time curve (AUCs) of DOX and DOXol in rats pretreated with ADI were 3.79-fold and 2.92-fold higher, respectively, than those in control rats that did not receive ADI. Conclusions Increased levels of DOX and DOXol were found in the plasma of HCC rats pretreated with ADI.

INTRODUCTION Intra-aortic balloon pump (IABP) is a mechanical device that increases cardiac output by increasing diastolic blood flow to the coronary arteries and lowers the afterload of the left ventricle in systole. IABP is primarily used in acute heart failure, that includes patients that have to undergo coronary artery bypass grafting (CABG). Its usage, however, in cardiac surgery has been declining with ongoing controversy regarding its benefits. The aim of this study was to assess the use and indications and outcome of IABP related to CABG surgery. MATERIAL AND METHODS The study was retrospective and included 2177 patients that underwent CABG at Landspitali during 2001-2018. We compared those who received an IABP with controls, using uni- and multivariate analysis. Long term survival and complications (major adverse cardiovascular and cerebral events, MACCE) was estimated with Kaplan-Meier method. RESULTS A total of 99 (4.5%) patients received an IABP. The incidence was highest in 2006 (8.9%) and lowest in 2001 (1.7%), but the incidence did not change during the study period (p=0.90). Most patients received the pump before (58.6%) or during (34.3%) CABG, but only 6.1% after surgery. Complication rate was 14.1%, with bleeding from the insertion site in the groin being the most common complication. Thirty day mortality was higher in the IABP group compared with controls (22.2% vs 1.3%, p

Chemical surface treatment of colloidal quantum dots (CQDs) by phase-transfer ligand exchange (PTLE) is essential to implement highly densified, well-passivated CQD films for optoelectronic applications, such as infrared photovoltaics, light-emitting diodes and photodetectors. The PTLE, however, involves parallel and interactional processes of ligand exchange, phase transfer, and surface passivation of CQDs, which renders the optimization of PTLE still challenging. Herein, we explored the action mechanism of a widely-used additive, ammonium acetate (AA), on the PTLE of PbS CQDs in order to recognize the dynamic balance during the PTLE process and its impact on the performance of colloidal quantum dot solar cells (CQDSCs). Our research definitely shows that AA additive can modify the dynamics of PTLE by participating in all the three processes, and the amount of AA significantly influences the defect passivation and colloidal stability of PbS CQDs. At an appropriate concentration (~50 mM) of AA, PbS CQDs a...

Parallel relay is an effective way to extend wireless communication distance. Employing multiple-input multiple-output (MIMO) relay can improve communication quality on a large scale, but the communication efficiency is reduced due to channel estimation. In this study, a mutual information-based estimate-and-forward scheme is proposed based on unitary space-time modulation in MIMO system. An equivalent transmission model is also constructed by regarding that the source signal is affected by a multiplicative factor and an additive noise. Based on this equivalent MIMO model, the generalized signal-to-noise ratio and global mutual information of the forwarding schemes are calculated. Error rate and mutual information analysis show that the proposed soft information forwarding can improve the reliability of parallel relaying system and has a better error rate performance than all the existing memory-less forwarding schemes.

With the rapid development of computer vision and machine vision, deep learning based methods have achieved good results in the field of target detection, recognition, and tracking. However, for ship detection and recognition on the sea surface, the detection and recognition rate is greatly affected by the uneven distribution of the horizontal and vertical features for ships and the different sizes of ships. In order to improve the ship detection accuracy and real-time performance, this paper proposed a ship detection algorithm based on YOLO V5, in which the feature extraction process was merged with the GhostbottleNet algorithm. Specifically, the algorithm consisted of two stacked GhostNet to refine and capture the image features, so as to overcome the incomprehensive feature capture problem in the original YOLO V5 network due to the inhomogeneous distribution of ship image features in transverse and vertical. Experimental results show that the proposed method not only improves the detection accuracy of YOLO V5 algorithm but also makes the GIoU decrease steadily.

BACKGROUND This study aimed to determine the value of the significant index in predicting symptomatic radiation pneumonitis (RP) in esophageal cancer patients, establish a nomogram prediction model, and verify the model. MATERIAL AND METHODS The patients enrolled were divided into 2 groups: a model group and a validation group. According to the logistic regression analysis, the independent predictors for symptomatic RP were obtained, and the nomogram prediction model was established according to these independent predictors. The consistency index (C-index) and calibration curve were used to evaluate the accuracy of the model, and the prediction ability of the model was verified in the validation group. Recursive partitioning analysis (RPA) was used for the risk stratification analysis. RESULTS The ratio of change regarding the pre-albumin at the end of treatment (P=0.001), platelet-to-lymphocyte ratio during treatment (P=0.027), and neutrophil-to-lymphocyte ratio at the end of treatment (P=0.001) were the independent predictors for symptomatic RP. The C-index of the nomogram model was 0.811. According to the risk stratification of RPA, the whole group was divided into 3 groups: a low-risk group, a medium-risk group, and a high-risk group. The incidence of symptomatic RP was 0%, 16.9%, and 57.6%, respectively. The receiver operating characteristic curve also revealed that the nomogram model has good accuracy in the validation group. CONCLUSIONS The developed nomogram and corresponding risk classification system have superior prediction ability for symptomatic RP and can predict the occurrence of RP in the early stage.

To explore the application of self-efficacy in X-ray image analysis based on deep convolutional neural network (DCNN) in the care and treatment of osteoporosis patients with rheumatoid arthritis. In this study, 90 patients with osteoporosis were divided into the control group and the experimental group for DCNN combined with X-ray diagnosis. Patients in the control group were given routine nursing care, and those in the experimental group were given comprehensive nursing care. The bone mineral content, self-efficacy, anxiety, and depression in the femur and lumbar spine after care were compared. The results showed that the accuracy, sensitivity, and false-negative rate of X-ray image recognition of osteoporosis based on DCNN were 91%, 98%, and 2%, respectively. The bone mineral contents of femur and lumbar vertebra in the experimental group were significantly higher than those in the control group ( P < 0.05 ). The anxiety, depression, and self-efficacy scores of patients in the experimental group were significantly higher than those in the control group ( P < 0.05 ). In conclusion, the accuracy rate of DCNN combined with X-ray plain film imaging in the detection of osteoporosis is high. Comprehensive nursing intervention can improve the curative effect and self-efficacy of patients. The improvement of self-efficacy is a related factor for the improvement of patients’ negative emotions and quality of life.

Background Aidi Injection (ADI), a Chinese herbal preparation with anti-cancer activity, is used for the treatment of hepatocellular carcinoma (HCC). Several clinical studies have shown that co-administration of ADI with doxorubicin (DOX) is associated with reduced toxicity of chemotherapy, enhanced clinical efficacy and improved quality of life for patients. However, limited information is available about the herb-drug interactions between ADI and DOX. The study aimed to investigate the pharmacokinetic mechanism of herb-drug interactions between ADI and DOX in a rat model of HCC. Methods Experimental HCC was induced in rats by oral administration of diethylnitrosamine. The HCC rats were pretreated with ADI (10 mL/kg, intraperitoneal injection) for 14 consecutive days prior to administration of DOX (7 mg/kg, intravenous injection) to investigate pharmacokinetic interactions. Plasma concentrations of DOX and its major metabolite, doxorubicinol (DOXol), were determined using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Results Preadministration of ADI significantly altered the pharmacokinetics of DOX in HCC rats, leading to increased plasma concentrations of both DOX and DOXol. The plasma drug concentration-time curves (AUCs) of DOX and DOXol in rats pretreated with ADI were 3.79-fold and 2.92-fold higher, respectively, than those in control rats that did not receive ADI. Conclusions Increased levels of DOX were found in the plasma of HCC rats pretreated with ADI, which may lead to enhanced efficacy but also potential toxicity.

Hepatocellular carcinoma (HCC) is a malignancy of liver cells. Recent studies have shown that HCC patients often have changes in the activities of transporters and metabolic enzymes, which can considerably affect drug pharmacokinetics and lead to drug toxicity. Doxorubicin (DOX) has been frequently administered in chemotherapy for HCC, but to our knowledge, the effects of HCC on the pharmacokinetics of DOX are unknown.In the present study, following intravenous administration of DOX in diethylnitrosamine-induced HCC rats, the plasma concentration was determined by a UPLC/MS/MS method. The expression of metabolic enzyme and transporters (p-gp, cbr1 and slc22a16) was analyzed by qRT-PCR and western blot.The results showed that the pharmacokinetic parameters AUC, T1/2, K12 and K21 of DOX were markedly increased, the K10 and CL were significantly decreased in HCC rats. The expression of cbr1 and slc22a16 was markedly decreased, while p-gp was significantly upregulated in HCC rats.These findings suggest that HCC could significantly alter the pharmacokinetic profile of DOX, which may be associated with the decreased expression of cbr1 and slc22a16 rather than the upregulation of p-gp expression.

Background To investigate high-risk HPV (hr-HPV) genotype distributions and the association between hr-HPV infection with severity of the cervical lesions in women with normal cytology. Methods In this cross-sectional study, the result of the hr-HPV test and biopsy of colposcopy of women with normal cytology from January 2012 to January 2019 were analyzed. The detection rate of high-grade squamous intraepithelial lesion (HSIL) and cervical cancer were calculated among different hr-HPV genotypes, viral load group, and age groups. Results Five thousand eight hundred eighty women were enrolled in this study. Overall, 59.97% had normal histological results, 19.32% had HSIL, and 1.07% had cervical cancer. The detection rate of HSIL or worse (HSIL+) in women with single HPV16(34.00%), HPV31(27.50%), HPV33(25.58%), and HPV52(20.88%) infection were higher significantly than single HPV18 (15.59%) infection, respectively. The HSIL+ detection rate between HPV16 single infection and multiple infections (excluding HPV18) was no significant difference (34% vs 35.47%, P = 0.638), contrary to HPV18(12.59% vs 21.67%, P = 0.022). In women without HPV16/18 infections, HSIL+ detection rates for single, double, and triple or more hr-HPV infections were 12.28, 20.31, and 37.50%, the risk of detection of HSIL+ significantly increasing. With the hr-HPV DNA load increases, the risk of detection of HSIL+ (χ2 = 91.01, P P = 0.016) increase. In age 60 group, HSIL+ detection rate were 24.80%、22.10%、19.59%、14.29, and 12.61%, respectively. Conclusion Women who have normal cytology with HPV 16/18/31/33/52/58 infections, multiple HPV infections and high viral load, have a higher detection rate of HSIL+.

Mechanical deviations induced by working conditions are always ignored in assembly analysis due to the rigid body hypothesis of parts. This paper presents a study of the deviations resulting from the actual working conditions. Finite element analysis (FEA) is conducted to simulate the deviations occurring in assemblies, in which the point-cloud geometry representation of deformed parts is adopted to enable the calculation of small displacements by means of relative positioning. The simulated deviations are incorporated in manufacturing deviations to determine the functional requirements based on Jacobian-torsor model. The approach is finally illustrated by a practical example.

Bi2−XErXWO6 photocatalysts were synthesized by a microwave solvothermal-calcination method. The Er3+ ions were doped into the crystal of Bi2WO6 and the photocatalysts show an up-conversion effect of the Er3+ 4f electrons: 4I15/2 → 4F7/2, 4I15/2 → 2H11/2, 4I15/2 → 4S3/2 and 4I15/2 → 4F9/2. The Er3+ ions absorb NIR light and convert it into visible light so that extra photons and electrons-holes are generated. The degradation rates of the Bi2−XErXWO6 photocatalyst reach 96% within 270 min and 95% within 30 min under the simulated sunlight and NIR light, which confirms the enhancement of the degradation performance by the up-conversion effect.

Measurement uncertainty is one of the most important concepts in geometrical product specification (GPS). Monte Carlo method (MCM) is widely used to evaluate uncertainty in many cases. However, the main drawback of this method is that it is necessary to generate very large samples. In this paper, a Quasi-Monte Carlo method based on good point set is proposed for the evaluation of measurement uncertainty of cylindricity error. The proposed method is tested in comparison with GUM method and Monte Carlo method, which shows the proposed method has the advantages of less computation time and better precision.

Since the moving element method (MEM) is an elegant method for solving problems involving moving loads. This paper extends the moving element method to the dynamic response of the water-saturated subgrade surface layer under a high-speed train. The track model is described as the Euler beam to simulate the rail, concrete slab layer and elastic medium to simulate the concrete base layer. The water-saturated subgrade surface layer is characterized by Biot’s dynamic poroelastic theory, and the other subgrade components are regarded as elastic medium. The governing equations are formulated in a coordinate system traveling at a constant velocity, and the associated finite element formulation in a moving frame of reference is derived. The proposed computational scheme is applied to investigate the dynamic characteristics of the water-saturated subgrade surface layer subjected to the moving train load. The effects of various key parameters including the train velocity, permeability, drainage boundary, elastic modulus and rail irregularity on hydro-mechanical response of the saturated subgrade surface layer are carefully analyzed.

Highly efficient mpg-C3N4/BiPO4 heterostructured photocatalysts were successfully synthesized via a facile ultrasonic chemical method. The structure, morphology, surface composition and chemical state of mpg-C3N4/BiPO4 hybrid photocatalysts were characterized by XRD, TEM, FTIR and XPS, respectively. Their photocatalytic activity was evaluated under visible light, UV light and solar light irradiation against the photodegradation of rhodamine B (RhB). BiPO4 nanorod was anchored on the surface of mpg-C3N4 nanosheets and the strong electrostatic interaction between mpg-C3N4 and BiPO4 facilitated the formation of mpg-C3N4/BiPO4 heterostructure. Under visible light irradiation, O2− and h+ were the two primary active species. BiPO4 served as an electron trap to efficiently promote the separation of photogenerated electron-hole pairs. The electrons in the CB of both BiPO4 and mpg-C3N4 could react with O2 adsorbed onto the surface of BiPO4/mpg-C3N4 and reduce it to form O2−, the holes left behind in the VB of mpg-C3N4 could not directly oxidize OH− or H2O to form OH. The 9.5CN/0.5BPO could degrade 92.3% of RhB in 30 min, which was about 1.3 times as high as that of mpg-C3N4. The TOC removal rate of 9.5CN/0.5BPO was 1.23 times higher than that of mpg-C3N4. Under UV light irradiation, O2−, h+ and OH were the primary active species, the inhibition degree followed the order BQ > EDTA-2Na > TBA. The electrons in the CB of both BiPO4 and mpg-C3N4 could react with O2 to generate O2−, the holes in the VB of BiPO4 could react with OH− or H2O to produce OH. The 9.5CN/0.5BPO could degrade 94.3% of RhB in 6 min, which was approximately 4.2 times higher than that of BiPO4 and 1.5 times larger than that of mpg-C3N4. The TOC removal rate of 9.5CN/0.5BPO was 6.98 times higher than that of P25. HPLC analysis proved that the destruction of the conjugated structure of RhB would be the major process. Based on the experimental results, a possible charge transfer mechanism for the enhanced visible and UV light photocatalytic activity was proposed.

In this paper, the research work of image recognition is carried out in the face of the detection of illegal intrusion objects in power transmission lines. By analyzing the current intelligent monitoring and real-time prediction related technologies, Based on the image data of binocular camera, the method of identifying illegal foreign objects is mainly studied under the condition of constructing line space equation. The research on identification method proposes the use of continuous inter-frame difference method and background difference method to detect foreign object recognition, which can effectively overcome the problem of missed detection of static foreign objects, shadow misdetection and inability to locate foreign objects in the foreign object detection algorithm based on image difference. And using the point cloud to calculate the spatial distance, it can accurately obtain the distance from the invading foreign object to the line. And the feasibility of the verification method on site.

Background To investigate reasonable treatment modalities and prognostic factors for patients with differentiated thyroid carcinoma (DTC) bone metastases (BM). Methods The clinicopathological characteristics and follow-up data for all patients with DTC BM who received treatment in the Third Affiliated Hospital of Kunming Medical University between November 1, 1993 and December 31, 2016 were analyzed retrospectively with respect to mortality and survival rates. Multivariate analysis was performed using the Cox proportional hazard model. Results The 5- and 10-year overall survival (OS) rates were 51.5% and 17.2%, respectively, for all 60 patients. Univariate analysis showed that patients diagnosed with BM at

The horizontal bending angle of scraper conveyor has a great influence on the running resistance, the current consumption, coal winning efficiency of the working surface, etc. Approximately 1&ndash, 3&deg, is usually the range of horizontal bending angle, but does not indicate the optimum bending angle of the coal mining face. To find the optimal horizontal bending angle, an optimization method is proposed. A mathematical calculation model of the running resistance of the scraper is established based on the direction of the shearer operation. Then, a method of adjusting the step size of the search by inertia weight and expanding fly distance range obeying the t-distribution is proposed based on the basic bat algorithm (BA). Finally, an industrial application was conducted in 21220 Changcun fully mechanized coal mining face, Henan Province. The results show that the current consumption by the scraper conveyor was reduced by 31% when the horizontal bending angle of the S-bending area was 0.66&deg, Meanwhile, the theoretical current has good consistency with the experimental data, and the average absolute error was 3%.

Inflammatory bowel disease (IBD) is a refractory illness with remarkably increasing incidence rate all over the world. However, no desirable treatment scheme is available. Therefore, research and development of new drugs for treating IBD are urgently needed. Histone deacetylase 6 (HDAC6) is considered to be a pro-inflammatory factor, thus the inhibitors specifically-targeting HDAC6 may find their way in IBD treatment. In this study, we evaluated the anti-inflammatory activity of a novel potent and selective HDAC6 inhibitor, LTB2, in dextran sulfate sodium (DSS)-induced colitis mouse model. It was found that LTB2 treatment significantly alleviated DSS-induced colitis in mice, as evidenced by body weight, colon length, histological examination, and the disease activity index (DAI) scores of rectal bleeding and diarrhea. More importantly, it showed a better protective effect on the DSS-induced colitis mice than the commonly used mesalazine in the clinic. Our results demonstrated that selective HDAC6 inhibitors may have a good prospect for IBD treatment.

An ultrawideband miniaturized metamaterial absorber (MMA) in the ultrahigh-frequency (UHF) (0.3–3 GHz) range using a metallic incurved structure is proposed in this letter. Simulated results show that the bandwidth of the MMA with absorptivity more than 90% is 0.8–2.7 GHz with a relative bandwidth over 108%. The size of the unit cell is miniaturized to be only 20 × 20 mm $^2$ , about 0.0136 ${\lambda ^2}$ at the center frequency of 1.75 GHz. Both simulated and experimental results show high absorption for TE and TM polarization over a certain range of incident angles. A simplified equivalent circuit and the current distribution for the MMA are presented to gain an insight into the mechanism to attain broadband absorption. On the aspect of application prospects, the MMA is promising as absorbing elements in UHF-RFID systems and 4G communications.

Objective Inflammation is closely linked to pulmonary arterial hypertension (PAH). Salusin-β, a bioactive peptide, has been reported to participate in vascular inflammation. We therefore hypothesized that salusin-β contributes to monocrotaline (MCT)-induced PAH in rats. Methods Male Sprague-Dawley rats were treated with MCT (60 mg kg −1 , single intraperitoneal injection). Salusin-β expression in the lungs of the MCT-treated rats was evaluated using immunofluorescence staining, western blot, and real-time PCR. For salusin-β blockade assay, rats injected with MCT were given a chronic infusion of anti-salusin-β immunoglobulin G (IgG) (salusin-β blocker, 1.0 μg kg −1 h −1 ) or isotype-matched control IgG. Four weeks after MCT+anti-salusin-β treatment, the effects of salusin-β blockade were determined using hemodynamics, western blot, real-time PCR, and immunohistochemical detection. The effect of salusin-β on human pulmonary arterial endothelial cell (HPAEC) function was detected by adhesion and tube formation experiments in vitro. Results Salusin-β expression was significantly increased in the lungs of the MCT-treated rats, and immunofluorescence results showed that salusin-β was predominantly expressed in pulmonary macrophages and vascular endothelial cells. Salusin-β blockade significantly ameliorated PAH by acting against pulmonary vascular remodeling, decreasing macrophage infiltration, and reducing pro-inflammatory cytokine expression and nuclear factor-kappa B (NF-κB) activity in the lungs of the MCT-treated rats. In addition, salusin-β could induce cell adhesion and accelerate angiogenesis by activating the NF-κB pathway and promoting pro-inflammatory cytokine expression in the cultured HPAECs. This effect was suppressed by addition of the NF-κB inhibitor, N-acetyl-L-cysteine. Conclusions Salusin-β plays a crucial role in the development of MCT-induced PAH models.

In this paper, the imaging quality of a three-aperture Golay3 imaging system is studied. The formula of point spread function (PSF) is derived when piston errors exist among each subaperture. The 1951 resolution target is used to analyze the imaging quality under the influence of different piston errors. To evaluate the imaging quality quantificationally, the Tenengrad function based on image gradient definition is employed. The fast steering mirror (FSM) controlled by PZT is used to eliminate the phase error in the optical structure of the Golay3 imaging system. The principle and formula of piston error correction are introduced. Using the Tenengrad function, the relationship between the movement of PZT and the image sharpness is obtained. Through the simulation of piston error correction, the piston error p = λ/2 in the system can be completely corrected when the PZT movement p’ = 0.35λ.

A novel design of high-gain dual-band dual-circular-polarised antenna loaded with reflective metasurface is proposed. The proposed antenna consists of a linear-polarised coplanar waveguide antenna with a polarisation-switched metasurface structure. The metasurface is composed of 25 unit cells arranged in a 5 × 5 layout and each unit cell is a pair of symmetrical semi-circle loop with a diagonal microstrip, which is designed to adjust the axial ratio for dual-band circular polarisation. Simulated result shows that the impedance bandwidth of the proposed antenna is about 63% from 3.8 to 7.3 GHz, and the average boresight gain has a great enhancement of about 4 dBi. The proposed antenna possesses the characteristic of right-handed circular polarisation from 4.15 to 4.45 GHz, while the left-handed circular polarisation is from 5.75 to 6.4 GHz. The simulated and measured results are in good agreement so that the performance of the proposed antenna can be confirmed.

On January 15, 2020, the representatives of Sino-US trade signed Phase I Economic and Trade Agreement Between the Government of the People’s Republic of China and the Government of the United States of America in Washington, which symbolizes the temporary settlement of two-year Sino-US trade war in relatively peaceful method and lays a good foundation in mutual trust for subsequent Phase II negotiation. This Agreement includes eight chapters involving Sino-US economic and trade and is called the model of the international bilateral agreement by virtue of its wide field and rigorous details. The impact of clauses about intellectual property rights on China’s current legal system and the future revision direction of China’s relevant laws for conformance with the Agreement will be discussed emphatically so that the author can rapidly understand the impact and significance of Sino-US trade agreement to Chinese law.

A new method aimed to design wideband microstrip antennas with low radar cross section (RCS) is proposed in this paper. The reflection phase inverse points and the 0° phase reflection points of the AMC unit cells can be designed to obtain 180°(± 30°) effective phase difference over broadband frequency range. The antenna is fabricated on a chessboard configuration which is structured with two AMC unit cells. Both simulated and measured results show that the proposed antenna possesses more than 7 dB RCS reduction with 69.2% relative bandwidth for both polarizations, covering the working band of the original antenna. The maximum reduction is 31.4 dB. Meanwhile, the radiation properties of the antenna are almost not changed.

After decades of rapid development by the Chinese construction industry, the management of the construction industry has increasingly relied on good models. Building information modeling (B...

Background Few studies have focused on postprandial incretin responses to different carbohydrate meals. Therefore, we designed a study to compare the different effects of two carbohydrates (75 g oral glucose, a monosaccharide and 100 g standard noodle, a polysaccharide, with 75 g carbohydrates equivalently) on postprandial glucose, insulin and incretin responses in different glucose tolerance groups. Methods This study was an open-label, randomized, two-way crossover clinical trial. 240 participants were assigned to take two carbohydrates in a randomized order separated by a washout period of 5–7 days. The plasma glucose, insulin, c-peptide, glucagon and active glucagon-like peptide-1 (AGLP-1) were measured. The incremental area under curve above baseline from 0 to 120 min of insulin (iAUC0–120 min-INS) and AGLP-1(iAUC0–120 min-AGLP-1) was calculated. Results Compared with standard noodles, the plasma glucose and insulin after consumption of oral glucose were higher at 30 min (both P

Alzheimer’s disease (AD) is the most common cause of dementia among elderly population. Deranged β-amyloid (Aβ) trafficking across the blood–brain barrier is known to be a critical element in the pathogenesis of AD. In the vascular endothelial cells of hippocampus, Aβ transport is mainly mediated by low-density lipoprotein-associated protein 1 (LRP1) and the receptor for advanced glycation end (RAGE) products; therefore, LRP1 and RAGE endothelial cells are potential therapeutic targets for AD. In this study, we explored the effects of Formononetin (FMN) on learning and memory improvement in APP/PS1 mice and the related mechanisms. We found that FMN significantly improved learning and memory ability by suppressing Aβ production from APP processing, RAGE-dependent inflammatory signaling and promoted LRP1-dependent cerebral Aβ clearance pathway. Moreover, FMN treatment alleviated ultrastructural changes in hippocampal vascular endothelial cells. In conclusion, we believe that FMN may be an efficacious and promising treatment for AD.

Supporting diverse services under a unified system is a major concern for the realization in the fifth generation (5G) cellular networks. In 5G systems, the massive connection property of massive machine-type communications (mMTC) results in the huge demand of physical downlink control channel (PDCCH) resources. Furthermore, greater overhead of PDCCH is indispensable for ultra-reliable downlink transmission in ultra-reliable and low-latency communications (URLLC), which exacerbates the shortage of PDCCH resources. In this paper, we propose a downlink group-downlink control information (DCI) based scheduling scheme to save control channel and improve the 5G system performance. Simulation results are finally provided to show that the PDCCH overhead can be greatly reduced and the reliability of downlink control information is enhanced.

It is necessary to research live working on UHV electrode line, so as to support DC UHV maintenance. As the electrode line of Zhengzhou converter station for example, the ground faults overvoltage on BP and GR modes were calculated. The maximum switching overvoltage was 288kV under the condition of live working. It was determined by the grounding fault of high end YY converter valves. The switching impulse flashover was carried in the live working air gaps of simulation tower. The results showed that the discharge voltages between worker's back and tower were lowest, and Discharge voltage of arcing horn was obviously higher than that between equipotent personnel and tower. The live working safety distance was calculated in usage. As the safety margin is 1.2, the safety distance is 0.65m. The electric field strength of live workers is less than 240kV/m, so the workers do not need to protect the electric field. And the maximum operating temperature of the conductor is less than 120 V, live working worker must avoid direct contact with high temperature wire, should use insulation tools or wear thermal insulation protective tools. Barehand method, insulating method and gloving method can be charged for electrode line. Above-mentioned results are available for reference to live working carried on other electrode lines of 800kV DC transmission project.

Lateral pressure coefficient is an important parameter in geological engineering, and it influences significantly the damage zone around boreholes. In accordance with the fundamental principles of the Particle Flow Code (PFC), various models were established to investigate the crack propagation patterns and energy evolution rules of coal in disturbed zones of hydraulic slotting for various lateral pressure coefficients. Cracks around a slotted borehole propagate in the horizontal direction when the lateral pressure coefficient λ is less than 1, distribute uniformly when λ is equal to 1, and extend mostly in the vertical direction when λ is greater than 1. The total number of cracks increases linearly with λ. The variation in kinetic energy for coal failure was recorded; kinetic energy evolution observes a similar rule and its process can be divided into four stages, namely, the quick-release, rapid dissipation, drastic fluctuation, and stabilized stages. The peak value of the kinetic energy increases linearly with λ. The acoustic emission events distribute discretely when λ is small and uniformly when λ is equal to 1. The variation in acoustic emission events tends to increase sharply before decreasing when λ is greater than 1. The research findings are significant to the exploration of pressure relief mechanisms for hydraulic slotting from a microcosmic perspective.

Pathological changes in animal models of autoimmune hepatitis and liver cells were similar to the mechanism of injury and viral hepatitis, the thesis of the active component of several common liver substances studied, wild chrysanthemum extract has anti-bacterial, anti-viral, pharmacological effects such as anti-inflammatory and immune liver and nerve protection, Dicliptera polysaccharide with excellent hepatoprotective activity of the liver that can be used as an adjunct to clinical medicine. Introduction

With the rapid development of the complexity and diversification of robot services, large number of data processing and analysis problems occurred during the robot working process. In this paper, we designed a collaborative system consisted multi-user and multi-robot based on cloud platform. By pre-setting the rights and restrictions owned by each user in different scenarios, the server determines the scene in which the robot is located by the picture taken by the robot, thereby giving each user different permissions. Enable the robot to listen to the user’s instructions to protect privacy. The integration of cloud technology and multi-robot systems made it possible to improve energy efficiency, real-time performance and reduce memory cost.

With the construction and development of UHV power transmission projects in China, safety are becoming increasingly important in the line operation and maintenance. The line operators must verify the electricity status of the transmission line before they carry out the work of maintenance. Due to the characteristics of UHV line, the electricity detection device on UHV line is different from the traditional ones. In this paper, an electricity inspection system based on Beidou satellite communication technology is established by means of non-contact Micro-Electro-Mechanism System (MEMS) electric field sensor. The system includes electricity detection device, handheld inquiry device and monitoring center. Experiments at actual transmission line verified the validation of the electricity inspection system.