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Simple Summary Acute myeloid leukemia (AML) is a cancer characterized by impaired differentiation and excessive expansion of blood progenitor cells leading to their accumulation in the bone marrow and circulation. The aim of this review is to describe how these leukemic cells can influence the immune system, particularly T lymphocytes that originate from the thymus and are involved in cancers’ and infections’ eradication. We focus on the elderly population, as this disease mainly affects people over 60 years-old. We discuss how AML cells can modify T lymphocytes’ production and functions. We also highlight newly developed therapeutic strategies to improve the anti-leukemic immune response and the clinical outcome of patients. Abstract Acute myeloid leukemia (AML) is a heterogeneous disease driven by impaired differentiation of hematopoietic primitive cells toward myeloid lineages (monocytes, granulocytes, red blood cells, platelets), leading to expansion and accumulation of “stem” and/or “progenitor”-like or differentiated leukemic cells in the bone marrow and blood. AML progression alters the bone marrow microenvironment and inhibits hematopoiesis’ proper functioning, causing sustained cytopenia and immunodeficiency. This review describes how the AML microenvironment influences lymphoid lineages, particularly T lymphocytes that originate from the thymus and orchestrate adaptive immune response. We focus on the elderly population, which is mainly affected by this pathology. We discuss how a permissive AML microenvironment can alter and even worsen the thymic function, T cells’ peripheral homeostasis, phenotype, and functions. Based on the recent findings on the mechanisms supporting that AML induces quantitative and qualitative changes in T cells, we suggest and summarize current immunotherapeutic strategies and challenges to overcome these anomalies to improve the anti-leukemic immune response and the clinical outcome of patients.

Introduction : depuis deux decennies, on assiste a l’emergence et a la re emergence de nombreuses maladies infectieuses. L’augmentation de la morbidite et de la mortalite de ces maladies a des consequences importantes en pratique dentaire essentiellement en matiere de protection contre la transmission des agents infectieux lors des soins effectues sur des patients infectes.

Amniotic band syndrome (ABS) is a collection of fetal congenital malformations affecting mainly the limbs, but also the craniofacial area. The pathogenic mechanism is still unclear. The facial malformations in ABS are multiple, polymorphous, and asymmetric. The type and extent of facial defects depend on band location and time of onset. Defects may include a combination of facial cleft, cleft palate and lip, ocular lesions, and cranial malformations. The management of this disease must be multidisciplinary and the outcome depends on the gravity of malformations.

Summary The solitary maxillomandibular bone cyst is a benign bone lesion with a nontumoral osteolysis and a progressive growth potential. It is considered as a pseudocyst because of the absence of epithelium and accounts for 1% of bone cysts. Most facial solitary bone cysts are observed in the mandible, especially in the corpus, and in young patients. Its etiopathogeny is unknown. The solitary bone cyst is asymptomatic. It is often discovered accidentally by radiolucent lacuna. Adjacent teeth vitality is preserved. The differential diagnosis is that of mandibular radiolucent lacuna etiologies. The diagnosis is confirmed by the surgical approach. Treatment is based on wall cavity curettage. It is usually relatively benign but the issue is discussed in publications because of the up to 26% of recurrence, requiring radiographic follow-up.

Nous rapportons l'observation d'une jeune femme de 26 ans ayant une sclerodermie systemique diffuse presentant une atteinte bucco-dentaire complexe: microstomie, hyperplasie gingivale, parodontite, depots tartriques, caries multiples et chevauchement dentaire antero-inferieur. Nous discuterons a travers cette observation les manifestations bucco-dentaires de cette connectivite qui sont loin d’etre rares mais souvent negligees par les cliniciens malgre leur retentissement fonctionnel majeur. Il convient de surveiller regulierement l’etat bucco-dentaire chez tout patient sclerodermique afin de diagnostiquer precocement ces atteintes. Diagnostiquees a un stade tardif les complications bucco-dentaires de la sclerodermie seront tres difficiles a traiter.

This paper deals with the design and hardware prototyping of Integral Backstepping controllers for a Quad Tilt Wing type of Unmanned Aerial Vehicles based on a National Instruments myRIO-1900 target and a host PC. The controllers’ parameters for the stabilization and tracking of the attitude and altitude hovering dynamics are tuned in real-time thanks to the proposed Computer Aided Design platform and within a Processor-In-the-Loop co-simulation framework. Such a developed software and hardware methodology is based on the Control Design and Simulation module of LabVIEW environment as well as a set-up Network Streams-based data communication protocol. A nonlinear model of the rotorcraft, which incorporates the dynamics of the vertical flight, is firstly given using the Newton-Euler formalism. Both Integral Backstepping controllers, for the attitude and heading dynamics as well as for the altitude and position states of the drone, are systematically designed and tuned. The proposed Integral Backstepping control strategy is compared to the classical Backstepping and PID control approaches in order to show its robustness superiority under external wind disturbances. Demonstrative software and hardware co-simulations are carried out and compared with each other in order to improve the real-world effectiveness of the proposed robust control approach for the Quad Tilt Wing aircraft navigation.