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To assess complex social recognition in mice, we previously developed the SocioBox paradigm. Unexpectedly, 4 weeks after performing in the SocioBox, mice displayed robust social avoidance during Y‐maze sociability testing. This unique “sociophobia” acquisition could be documented in independent cohorts. We therefore employed infrared thermography as a non‐invasive method of stress‐monitoring during SocioBox testing (presentation of five other mice) versus empty box. A higher Centralization Index (body/tail temperature) in the SocioBox correlated negatively with social recognition memory and, after 4 weeks, with social preference in the Y‐maze. Assuming that social stimuli might be associated with characteristic thermo‐responses, we exposed healthy men (N = 103) with a comparably high intelligence level to a standardized test session including two cognitive tests with or without social component (face versus pattern recognition). In some analogy to the Centralization Index (within‐subject measure) used in mice, the Reference Index (ratio nose/malar cheek temperature) was introduced to determine the autonomic facial response/flushing during social recognition testing. Whereas cognitive performance and salivary cortisol were comparable across human subjects and tests, the Face Recognition Test was associated with a characteristic Reference Index profile. Infrared thermography may have potential for discriminating disturbed social behaviors.

Gallium phosphide (GaP) is an indirect bandgap semiconductor used widely in solid-state lighting. Despite numerous intriguing optical properties---including large $��^{(2)}$ and $��^{(3)}$ coefficients, a high refractive index ($>3$), and transparency from visible to long-infrared wavelengths ($0.55-11\,��$m)---its application as an integrated photonics material has been little studied. Here we introduce GaP-on-insulator as a platform for nonlinear photonics, exploiting a direct wafer bonding approach to realize integrated waveguides with 1.2 dB/cm loss in the telecommunications C-band (on par with Si-on-insulator). High quality $(Q> 10^5)$, grating-coupled ring resonators are fabricated and studied. Employing a modulation transfer approach, we obtain a direct experimental estimate of the nonlinear index of GaP at telecommunication wavelengths: $n_2=1.2(5)\times 10^{-17}\,\text{m}^2/\text{W}$. We also observe Kerr frequency comb generation in resonators with engineered dispersion. Parametric threshold powers as low as 3 mW are realized, followed by broadband ($>100$ nm) frequency combs with sub-THz spacing, frequency-doubled combs and, in a separate device, efficient Raman lasing. These results signal the emergence of GaP-on-insulator as a novel platform for integrated nonlinear photonics., 13 pages, 10 figures, 1 table; typos corrected, added/fixed references, modified title

The development of integrated photonic circuits utilizing gallium phosphide requires a robust, scalable process for fabrication of GaP-on-insulator devices. Here we present the first GaP photonic devices on SiO$_2$. The process exploits direct wafer bonding of a GaP/Al$_x$Ga$_{1-x}$P/GaP heterostructure onto a SiO$_2$-on-Si wafer followed by removal of the GaP substrate and the Al$_x$Ga$_{1-x}$P stop layer. Photonic devices such as grating couplers, waveguides, and ring resonators are patterned by inductively coupled-plasma reactive-ion etching in the top GaP device layer. The peak coupling efficiency of the fabricated grating couplers is as high as 4.8 dB. Optical quality factors of 17000 as well as second- and third-harmonic generation are observed with the ring resonators. Because the large bandgap of GaP provides for low two-photon absorption at telecommunication wavelengths, the high-yield fabrication of GaP-on-insulator photonic devices enabled by this work is especially interesting for applications in nanophotonics, where high quality factors or low mode volumes can produce high electric field intensities. The large bandgap also enables integrated photonic devices operating at visible wavelengths.

Background: Multiple sclerosis (MS) patients are at risk of renewed disease activity after discontinuing natalizumab (NAT) treatment. Objective: Assessing the implication of T helper 17 (Th17) cells in MS reactivation after NAT cessation. Methods: We monitored frequencies of Th17 cells and interleukin (IL)-17 cytokine levels in blood samples of 57 MS patients, without, during, and after NAT exposure. Results: Frequencies of both Th17 cells and, in part, also IL-17 levels, in peripheral blood increased under prolonged NAT therapy, returned to baseline after NAT withdrawal and became almost undetectable in blood samples of individuals who experienced relapses during the wash-out phase. Conclusion: Assessing the Th17-cell/IL-17 axis might help to predict rebound MS activity after NAT withdrawal.

In an effort to tackle the enormous challenges facing the global community, the United Nations Sustainable Development Goals (SDGs) and the Paris Agreement were adopted in 2015, followed by the New Urban Agenda (NUA) in 2016. Delivering infrastructure in a sustainable way is a crucial driver in achieving these objectives in India. It is considered vital for building competitiveness, facilitating economic growth, reducing poverty and improving the quality of life of the citizens in India. This chapter reviews voluntary governance in the domain of infrastructure and offers a detailed review of SuRe®—The Standard for Sustainable and Resilient Infrastructure, which has a strong interest and presence in India. The chapter argues that SuRe® can foster the potential for risk mitigation and benefit creation of sustainable infrastructure and thus contribute to overcoming the challenges that hinder investments in sustainable infrastructure.

Gallium phosphide offers an attractive combination of a high refractive index ($n>3$ for vacuum wavelengths up to 4 {\mu}m) and a wide electronic bandgap (2.26 eV), enabling optical cavities with small mode volumes and low two-photon absorption at telecommunication wavelengths. Heating due to strongly confined light fields is therefore greatly reduced. Here, we investigate the benefits of these properties for cavity optomechanics. Utilizing a recently developed fabrication scheme based on direct wafer bonding, we realize integrated one-dimensional photonic crystal cavities made of gallium phosphide with optical quality factors as high as $1.1\times10^5$. We optimize their design to couple the optical eigenmode at $\approx 200$ THz via radiation pressure to a co-localized mechanical mode with a frequency of 3 GHz, yielding sideband-resolved devices. The high vacuum optomechanical coupling rate ($g_0=2\pi\times 400$ kHz) permits amplification of the mechanical mode into the so-called mechanical lasing regime with input power as low as $\approx 20$ {\mu}W. The observation of mechanical lasing implies a multiphoton cooperativity of $C>1$, an important threshold for the realization of quantum state transfer protocols. Because of the reduced thermo-optic resonance shift, optomechanically induced transparency can be detected at room temperature in addition to the normally observed optomechanically induced absorption., Comment: 11 pages, 13 figures

We demonstrate the first microresonator frequency combs in GaP, a III-V semiconductor transparent above 549 nm. High Kerr nonlinearity (> 10−18 m2/W) yields a 10-mW parametric threshold and 100-nm-wide combs with THz spacing, centered at 1550 nm.

Gallium phosphide (GaP) is an attractive material for non-linear optics because of its broad transparency window (λ_vac > 548 nm) and large Kerr coefficient (n_2 ~ 6 × 10^-18 m^2/W). Though well-established in the semiconductor industry as a substrate for visible LEDs, its use in integrated photonics remains limited due to fabrication challenges. Recently we have developed a method to integrate high quality, epitaxially-grown GaP onto silica (SiO2) based on direct wafer bonding to an oxidized silicon carrier wafer. Here we exploit this platform to realize unprecedentedly low loss (Q > 3 × 10^5) GaP-on-SiO2 waveguide resonators which have been dispersion-engineered to support Kerr frequency comb generation in the C-band. Single-mode, grating-coupled ring resonators with radii from 10 – 100 μm are investigated. The threshold for parametric conversion is observed at input powers as little as 10 mW, followed by 0.1 – 1 THz frequency comb generation over a range exceeding 400 nm, in addition to strong second- and third-harmonic generation. Building on this advance, we discuss the prospects for low-noise, sub-mW-threshold soliton frequency combs with center frequencies tunable from the mid-IR to the near-IR. Applications of such devices range from precision molecular spectroscopy to ultrafast pulse generation to massively parallel coherent optical communication.

Background In Parkinson’s disease (PD), cerebral dopamine depletion is associated with PD subtype-specific metabolic patterns of hypo- and hypermetabolism. It has been hypothesised that hypometabolism reflects impairment, while hypermetabolism may indicate compensatory activity. In order to associate metabolic patterns with pathophysiological and compensatory mechanisms, we combined resting state [18F]FDG-PET (to demonstrate brain metabolism in awake animals), [18F]FDOPA-PET (dopamine depletion severity) and gait analysis in a unilateral 6-hydroxydopamine rat model. Results We found unilateral nigro-striatal dopaminergic loss to decrease swing speed of the contralesional forelimb and stride length of all paws in association with depletion severity. Depletion severity was found to correlate with compensatory changes such as increased stance time of the other three paws and diagonal weight shift to the ipsilesional hind paw. [18F]FDG-PET revealed ipsilesional hypo- and contralesional hypermetabolism; metabolic deactivation of the ipsilesional network needed for sensorimotor integration (hippocampus/retrosplenial cortex/lateral posterior thalamus) was solely associated with bradykinesia, but hypometabolism of the ipsilesional rostral forelimb area was related to both pathological and compensatory gait changes. Mixed effects were also found for hypermetabolism of the contralesional midbrain locomotor region, while contralesional striatal hyperactivation was linked to motor impairments rather than compensation. Conclusions Our results indicate that ipsilesional hypo- and contralesional hypermetabolism contribute to both motor impairment and compensation. This is the first time when energy metabolism, dopamine depletion and gait analysis were combined in a hemiparkinsonian model. By experimentally increasing or decreasing compensational brain activity, its potential and limits can be further investigated.

The visual tasks consist in perception of presence (detection) of targets. If the luminance of the object to be detected is high enough to achieve 95% detection probability at a distance that is longer than the stopping distance of the vehicle accidents can be avoided. Two different target shapes that occur in road traffic situations are observed in a field study under different eccentricity angles. Two measurement methods, static and dynamic, were developed for determining the visibility distance. Results for the visibility distance based on increment detection contrast are discussed.

Image-guided medical interventions more frequently rely on Augmented Reality (AR) visualization to enable surgical navigation. Current systems use 2-D monitors to present the view from external cameras, which does not provide an ideal perception of the 3-D position of the region of interest. Despite this problem, most research targets the direct overlay of diagnostic imaging data, and only few studies attempt to improve the perception of occluded structures in external camera views. The focus of this paper lies on improving the 3-D perception of an augmented external camera view by combining both auditory and visual stimuli in a dynamic multi-sensory AR environment for medical applications. Our approach is based on Temporal Distance Coding (TDC) and an active surgical tool to interact with occluded virtual objects of interest in the scene in order to gain an improved perception of their 3-D location. Users performed a simulated needle biopsy by targeting virtual lesions rendered inside a patient phantom. Experimental results demonstrate that our TDC-based visualization technique significantly improves the localization accuracy, while the addition of auditory feedback results in increased intuitiveness and faster completion of the task.

We describe the design, fabrication, and characterization of a one-dimensional silicon photonic crystal cavity in which a central slot is used to enhance the overlap between highly localized optical and mechanical modes. The optical mode has an extremely small mode volume of 0.017(λsubvac/sub / n)sup3/sup, and an optomechanical vacuum coupling rate of 310 kHz is measured for a mechanical mode at 2.69 GHz. With optical quality factors up to 1.2 × 10sup5/sup, fabricated devices are in the resolved-sideband regime. The electric field has its maximum at the slot wall and couples to the in-plane breathing motion of the slot. The optomechanical coupling is thus dominated by the moving-boundary effect, which we simulate to be six times greater than the photoelastic effect, in contrast to most structures, where the photoelastic effect is often the primary coupling mechanism.

SummaryCompared to warfarin, little is known about the effect of pharmacogenomics on the inter-individual variability of phenprocoumon therapy. In a retrospective cohort study, we investigated the impact of VKORC1 c.-1639G>A; CYP2C9*2, CYP2C9*3; GGCX c.214+597G>A; CALU c.*4A>G; EPHX1 c.337T>C; F7 c.-402G>A, and F7 c.-401G>T on the initiation (n=54) and maintenance phases (n=91) of phenprocoumon therapy. We assessed the following outcome parameters: time to stable international normalised ratio (INR), time to first supra-therapeutic INR, time out of INR range, probability of over-anticoagulation, number of anticoagulation clinic visits. During the initiation phase, homozygotes for the VKORC1 c.-1639 A and G alleles achieved stable INRs later (p