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Relevance. The reason for the study was our histological specimen with intrapulpal dye injection from the monograph "Anesthesia in Endodontics". Outside the pulp chamber, in the root canal, the ink is diffusely distributed throughout the vessels. There was a hypothesis about the vascular nature of intrapulpal injection.Aim. Тo prove vascular mechanism intrapulpal injection.Materials and methods. A randomized prospective pilot study was performed in 15 patients (9 men, 6 women) with 15 teeth vital pulpectomy. Traditional anesthesia conducted articaine 4% with epinephrine 1:100 000. When accessed in the pulpintroduced drop the same anesthetic. Heart rate was determined after 30 seconds for 3 minutes pulse oximeter MD 300.Results. There was expressed vascular reaction to intrapulpal introduction anesthetic with epinephrine. It has resulted in a sharp increase in pulse rate by an average of 11.3 beats /min, return to the original level after 3 minutes. Conclusions. Based on the results obtained, we assume the vascular-venous nature of intrapulpal anesthesia.

Aim. То carry out a comparative assessment of the change in the pain threshold (in terms of electroodontometry), the X-ray width of the root canal in the apex area and the nature of the pain sensation of the central incisors in children aged 6.5-15 years.Materials and methods. We examined 280 teeth in 280 children from 6.5 to 15 years old (central incisors). Patients are divided by age into 5 groups: 1 - 6.5-7 years old; 2 - 7-8 years old; 3 - 9-10 years old; 4 - 11-12 years old; 5 - 13-15 years old. The patients underwent electroodontometry (EOM), to measure the sensitivity threshold of the studied tooth, the subjective sensations with EOM were assessed, and the width of the apical part of the root canal was determined, according to the data of intraoral sighting radiography.Results. The study studied the process of teething and formation of teeth in dynamics from 6.5 to 15 years in 5 age groups. Changes in electrodontometry (EOM) are significant from 140.38 цА (4.5 years) to 24.38 цА (15 years) - average data. The relationship between age and the width of the root canal in the area of the apex, which is also characterized by a gradual narrowing, has been traced. Pulp pain with EOM becomes clearer and more short-lived with age. The correlation between age and pain threshold is less pronounced (41%) than between age and apical canal width (72%). Conclusions. The main role in the sensitivity of the tooth is played by the A-delta and C nerve fibers of the pulp. The phenomenon of a decrease in the pain sensitivity threshold of permanent teeth during electrodontometry in the process of root formation due to the reaction of C-fibers was established.

Background. Improving nursing methods of newborns with birth weight less than 2500 g resulted in an increase in the proportion of children at risk for the development of severe disabling conditions. Objective: Our aim was to investigate the risk factors of the mother, associated with the birth of a child with a birth weight less than 2500 g. Methods. In a retrospective cohort study included 572 children born to 566 mothers in 5 perinatal centers. Risk assessment was carried out taking into account birth weight (in groups of children with normal, low, very low and extremely low birth weight). Results. Sample of mothers (n = 489), whose children had birth weight 2500 g, characterized by a mean age of 31 (26; 35) years, the growth of 164 (159; 168) cm, weighing when registering for pregnancy 62 (53; 74) and 70 kg (60; 80) kg just before birth. Among the independent predictors of birth weight infants were allocated as follows: maternal education (higher/more), mother occupation (housewife/other), presence of chronic diseases, anemia during pregnancy, the threat of premature births, growth and weight of the mother’s body before birth, weight gain body during pregnancy, body mass index (BMI) when registering for antenatal care in pregnancy and before delivery. Conclusion. Identified risk factors for maternal birth weight infants, which can be used to stratify pregnant women at risk.

Analysis of features of physical and neuro-psychological development of children with low, very low and extremely low birth weight in different age periods is carried out according to cohort studies of newborns with different gestational age and birth weight, presented in electronic databases PubMed and Medscape. It is revealed that the overwhelming number of children with low, very low and extremely low birth weight, gain physical and neuro- psychological development impairments, hearing and vision disorders of varying severity, violation of motor function, intelligence and cognitive skills infringement in an older age. In this regard, it is actual not only to develop new neonatal reanimation and intensive care technologies, but also to ensure adequate prevention of preterm birth in the group of women with a high degree of perinatal risk. All this will further allow preventing increase in children with disabling conditions number among premature infants.