1. P12.21 Surveillance of Incidental Meningiomas: A systematic Review and Meta-Analysis
- Author
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K. M. Mahmoud and A. P. Perera
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,business.industry ,Time to progression ,medicine.disease ,Conservative treatment ,Text mining ,Meta-analysis ,Internal medicine ,medicine ,Tumor growth ,Neurology (clinical) ,business ,POSTER PRESENTATIONS ,Calcification - Abstract
Introduction: Incidental meningiomas pose a prognostic challenge; while conservative management is generally accepted there are no definitive statistics which tell us which proportion of these patients progress and how best to predict this. A number of studies have reported the natural history of incidental meningiomas however it is challenging to accurately identify trends in isolation. To this end we aimed to undertake the first systematic review and meta-analysis of papers reporting on the surveillance of incidental meningiomas. METHODS: This systematic review and meta-analysis was conducted in accordance with the PRISMA statement and was prospectively registered with the PROSPERO database (CRD42016045550). Pubmed, CINAHL, google scholar and Embase were searched for the MeSH terms “incidental meningioma follow up” and “asymptomatic meningioma follow up”. Searches were conducted independently by two of the authors AP and KA and disputes were resolved until mutual agreement was reached. Papers including surveillance of asymptomatic meningiomas were included. Papers describing any interventions at the initial stage of management were excluded. Results: 11 papers were identified totalling 800 patients. 34% (weighted mean) of tumours showed progression along the course of surveillance with a weighted average of 54 months follow up. 4 papers reported the number of patients who developed symptoms which ranged from 3.4% to 12.5%. Calcification significantly reduced the risk of having tumour growth: OR 3.18[1.87,5.40] (P
- Published
- 2017