1. Prospective observational study of carbon-ion radiotherapy for non-squamous cell carcinoma of the head and neck in Gunma University
- Author
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Osamu Nikkuni, Nobuteru Kubo, Satoshi Yokoo, Masato Shino, Shota Ida, Katsuyuki Shirai, Neck Tumors, Tatsuya Ohno, Takuya Kaminuma, Hiro Sato, Naoko Okano, Masaru Ogawa, Jun-ichi Saitoh, Hidemasa Kawamura, Yukihiro Takayasu, Kazuaki Chikamatsu, and Atsushi Musha
- Subjects
medicine.medical_specialty ,Adenoid cystic carcinoma ,business.industry ,medicine.medical_treatment ,Head and neck cancer ,Common Terminology Criteria for Adverse Events ,medicine.disease ,Pathology and Forensic Medicine ,Radiation therapy ,Otorhinolaryngology ,Mucositis ,medicine ,Carbon Ion Radiotherapy ,Surgery ,Observational study ,Radiology ,Oral Surgery ,Adverse effect ,business - Abstract
Objective Data on the long-term outcomes of carbon-ion radiotherapy for non-squamous cell carcinomas are rare. Gunma University has been utilizing carbon-ion radiotherapy as a treatment for head and neck cancer since 2010. This study aimed to evaluate the long-term efficacy and safety of carbon-ion radiotherapy for the head and neck. Methods We prospectively evaluated 35 patients with non-squamous cell carcinoma who underwent carbon-ion radiotherapy at Gunma University Heavy Ion Medical Center between 2010 and 2014. The 5-year local control, overall survival, and progression-free survival rates were evaluated. Results The median age was 59 years (range, 31–77 years), and the median follow-up time was 65 months (range, 6.1–98.8 months). Overall, 32 and 3 patients received 64.0 Gy (relative biological effectiveness) and 57.6 Gy (relative biological effectiveness) in 16 fractions, respectively. Adenoid cystic carcinoma was the most dominant histopathological type (n = 21 patients, 60 %). The 5-year local control, progression-free survival, and overall survival rates were 74.5 %, 53.2 %, and 81.3 %, respectively. Nine patients had local recurrence, and six patients died. Adverse events included acute grade 3 radiation mucositis (Common Terminology Criteria for Adverse Events version 4.0) in 8 patients; this was improved immediately with conservative therapy. Late grade 4 adverse events were observed, including two cases of visual loss and one case of brain necrosis. No grade 5 adverse events were observed. Conclusion Carbon-ion radiotherapy achieves excellent local control and overall survival rates in non-squamous cell carcinoma patients with expected adverse events.
- Published
- 2022