1. Association of serum uric acid with biventricular myocardial dysfunction in patients with type 2 diabetes mellitus
- Author
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Qing-Wen Ren, Kai-Hang Yiu, Ju-Hua Liu, Ming-Yen Ng, Si-Min Li, Hung-Fat Tse, Mei-Zhen Wu, Qing-Shan Lin, and Yan Chen
- Subjects
Male ,medicine.medical_specialty ,endocrine system diseases ,Ventricular Dysfunction, Right ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Renal function ,Hyperuricemia ,Risk Assessment ,Asymptomatic ,Ventricular Function, Left ,Free wall ,Ventricular Dysfunction, Left ,Sex Factors ,Risk Factors ,Internal medicine ,Prevalence ,medicine ,Humans ,Circumferential strain ,In patient ,Aged ,Nutrition and Dietetics ,business.industry ,Serum uric acid ,nutritional and metabolic diseases ,Type 2 Diabetes Mellitus ,Middle Aged ,Prognosis ,Uric Acid ,Cross-Sectional Studies ,Diabetes Mellitus, Type 2 ,Quartile ,Echocardiography ,Ventricular Function, Right ,Cardiology ,Hong Kong ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Biomarkers - Abstract
Increased serum uric acid (SUA) is common in type 2 diabetes mellitus (T2DM) and is associated with left ventricular (LV) myocardial dysfunction. Nonetheless the association of SUA with right ventricular (RV) function in T2DM has not been studied. This study aimed to investigate the association of SUA with biventricular myocardial function in patients with T2DM.A total of 560 patients with T2DM were enrolled and divided into four groups according to sex-specific quartiles of SUA. Transthoracic echocardiography was performed and two-dimensional speckle tracking was used to measure biventricular myocardial strain, including LV global longitudinal strain (GLS), circumferential strain (CS), radial strain (RS), and RV free wall longitudinal strain (RV-FWLS). The absolute value of all biventricular strain parameters showed a stepwise decrease across SUA quartiles (all P 0.01). In particular, LV assessment by GLS, CS and RS demonstrated that those in the 4th quartile were impaired compared with the other quartiles (all P 0.05). Similarly, RV-FWLS of the 4th quartile was significantly impaired compared with the 1st and 2nd quartiles (all P 0.05). The same reduction in biventricular strain across SUA quartiles was observed in patients with estimated glomerular filtration rate or ≥60 ml/min/1.73 mSUA was independently associated with biventricular myocardial dysfunction in asymptomatic T2DM patients, regardless of renal function or diabetic control.
- Published
- 2021