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Forty planar superconducting undulators (SCUs) of 4 m length will be used in Shanghai High Repetition rate XFEL and Extreme Light (SHINE) facility. As the longest SCU in developing of the worldwide, they could generate photon in energy range of 10–25 keV. NbTi/Cu wires with the diameter 0.6 mm and the ratio of Cu to NbTi 0.9 have been chosen as the fundamental element of superconducting coils. Coils temperature must be below 5 K when operating current reaches 400 A. Meanwhile, the magnetic gap need to be less than 5 mm to obtain the peak field of 1.58 T. Therefore, beam chamber installation is infeasible in such a small gap. Two parallel copper foils close to the surface of magnetic poles have been designed to shield beam heat load. Furthermore, four liquid Helium tubes located symmetrically around magnetic structure have been designed to cool the copper foils used as beam channel. There is no cryocooler on the SCU because liquid Helium is provided by the cryogenic plant of SHINE.

Prelithiation has important applications to convert a nonlithiated cathode or anode materials into a controllably lithiated state required for developing advanced Li-ion batteries. However, most of...

Supercapacitors are attracting increasing research interest because they are expected to achieve battery-level energy density while having a long calendar life and a short charging time. However, the development of large-scale and cost-reasonable production methods for flexible, wearable and arbitrary-shaped supercapacitor devices still faces enormous challenges. Herein, a 3D-network, porous graphene/CoS2/Ni3S4 (G/CoS2/Ni3S4) composite electrode has been designed and synthesized through a combination of solvothermal and vulcanization methods. By combining the networked CoS2/Ni3S4 nanoflakes with reduced graphene oxide (RGO) nanosheets, the as-prepared composite electrode exhibits good conductivity, a high density of electrochemically active sites and good cycling stability. The result is a high specific capacitance of 1739 F g−1 at a current density of 0.5 A g−1. Significantly, the arbitrary-shaped G/CoS2/Ni3S4||GF hybrid supercapacitor devices can be printed directly on different substrates, which favorably combine mechanical flexibility, good cycling performance and high energy density. This methodology may be feasible to prepare fully-printable and wearable supercapacitors, and other electronic devices in large scale, thereby holding enormous potential for wearable technologies.

BackgroundAutophagy is a “self-feeding” phenomenon of cells, which is crucial in mammalian development. Long non-coding RNA (lncRNA) is a new regulatory factor for cell autophagy, which can regulate the process of autophagy to affect tumor progression. However, poor attention has been paid to the roles of autophagy-related lncRNAs in breast cancer.ObjectiveThis study aimed to construct an autophagy-related lncRNA signature that can effectively predict the prognosis of breast cancer patients and explore the potential functions of these lncRNAs.MethodsThe RNA sequencing (RNA-Seq) data of breast cancer patients was collected from The Cancer Genome Atlas (TCGA) database and the GSE20685 database. Multivariate Cox analysis was implemented to produce an autophagy-related lncRNA signature in the TCGA cohort. The signature was then validated in the GSE20685 cohort. The receiver operator characteristic (ROC) curve was performed to evaluate the predictive ability of the signature. Gene set enrichment analysis (GSEA) was used to explore the potential functions based on the signature. Finally, the study developed a nomogram and internal verification based on the autophagy-related lncRNAs.ResultsA signature composed of 9 autophagy-related lncRNAs was determined as a prognostic model, and 1,109 breast cancer patients were divided into high-risk group and low-risk group based on median risk score of the signature. Further analysis demonstrated that the over survival (OS) of breast cancer patients in the high-risk group was poorer than that in the low-risk group based on the prognostic signature. The area under the curve (AUC) of ROC curve verified the sensitivity and specificity of this signature. Additionally, we confirmed the signature is an independent factor and found it may be correlated to the progression of breast cancer. GSEA showed gene sets were notably enriched in carcinogenic activation pathways and autophagy-related pathways. The qRT-PCR identified 5 lncRNAs with significantly differential expression in breast cancer cells based on the 9 lncRNAs of the prognostic model, and the results were consistent with the tissues.ConclusionIn summary, our signature has potential predictive value in the prognosis of breast cancer and these autophagy-related lncRNAs may play significant roles in the diagnosis and treatment of breast cancer.

This article focuses on the simultaneous wireless information and power transfer (SWIPT) systems, which provide both the power supply and the communications for Internet-of-Things (IoT) devices in the sixth-generation (6G) network. Due to the extremely stringent requirements on reliability, speed, and security in the 6G network, aerial access networks (AANs) are deployed to extend the coverage of wireless communications and guarantee robustness. Moreover, sparse code multiple access (SCMA) is implemented on the SWIPT system to further promote the spectrum efficiency. To improve the speed and security of SWIPT systems in 6G AANs, we have developed an optimization algorithm of SCMA to maximize the secrecy sum rate (SSR). Specifically, a power-splitting (PS) strategy is applied by each user to coordinate its energy harvesting and information decoding. Hence, the SSR maximization problems in the SCMA system are formulated in terms of the PS and resource allocation, under the constraints on the minimum rates and minimum harvested energy of individual users. Then, a successive convex approximation method is introduced to transform the nonconvex problems to the convex ones, which are then solved by an iterative algorithm. In addition, we investigate the SSR performance of the SCMA system supported by our optimization methods, when the impacts from different perspectives are considered. Our studies and simulation results show that the SCMA system supported by our proposed optimization algorithms significantly outperforms the legacy system with uniform power allocation and fixed PS.

Organic-inorganic hybrid perovskites (OIHPs) have attracted extensive research interest as a promising candidate for efficient and inexpensive solar cells. Transmission electron microscopy characterizations that can benefit the fundamental understanding and the degradation mechanism are widely used for these materials. However, their sensitivity to the electron beam illumination and hence structural instabilities usually prevent us from obtaining the intrinsic information or even lead to significant artifacts. Here, we systematacially investigate the structural degradation behaviors under different experimental factors to reveal the optimized conditions for TEM characterizations of OIHPs by using low-dose electron diffraction and imaging techniques. We find that a low temperature does not slow down the beam damage but instead induces a rapid amorphization for OIHPs. Moreover, a less severe damage is observed at a higher accelerating voltage. The beam-sensitivity is found to be facet-dependent that a (100) exposed MAPbI3 surface is more stable than (001) surface. With these guidance, we successfully acquire the atomic structure of pristine MAPbI3 and identify the characterization window that is very narrow. These findings are helpful to guide future electron microscopy characterization of these beam-sensitive materials, which are also useful for finding strategies to improve the stability and the performance of the perovskite solar cells., Comment: 19 pages, 5 figures

Quasi-one-dimensional semiconducting materials have attracted increasing attention due to their excellent ability to downscale the size of transistors. However, in quasi-one-dimensional nanowire (NW) transistors, their surface and interface properties play a very important role mainly due to the large surface-to-volume ratio of NWs and surface scattering, which degrade their carrier mobility. Herein, we developed a new method to cover the channel surface of InAs NW field effect transistors (FETs) with Y2O3/HfO2 layers to improve their electrical properties. We successfully fabricated nine FETs and measured their electrical properties, which improve after depositing the Y2O3/HfO2 layers, including an increase in on-state current, decrease in off-state current, increase in transconductance, increase in electron mobility and decrease in subthreshold swing. By comparing the properties of Y2O3/HfO2-covered devices with that of the FETs fabricated without the Y2O3 covering or without annealing, we prove that it is the combined Y2O3/HfO2 layers instead of only the Y2O3 or HfO2 layer that improve the electrical properties of the FETs. The Cs-corrected high-resolution scanning transmission electron microscopy study demonstrates that Y can actually diffuse through the native oxide layer (confirmed to be InOx) and reach the surface of the InAs NWs. Our results indicate that the desirable characteristics of Y2O3 and the surface passivation by HfO2 improve the electrical properties of the InAs NW FETs, in which Y2O3 plays an important role to modify and stabilize the interface between the InAs NWs and the outside dielectric layer. Furthermore, this method should also be applicable to other III-V materials.

Quasi van der Waals (vdW) epitaxy, a pioneering epitaxy of sp3 -hybridized semiconductor films on sp2 -hybridized two-dimensional (2D) materials, provides a way, in principle, to achieve single-crystal epilayers with preferred atom configurations that are free of substrate. Unfortunately, this has not been experimentally confirmed in the case of the hexagonal semiconductor III-nitride epilayer until now. Here, for the first time, we report that the epitaxy of gallium nitride (GaN) on graphene can tune the atom arrangement (lattice polarity) through manipulation of the interface atomic configuration, where GaN films with gallium and nitrogen polarity were achieved by forming C-O-N-Ga(3) or C-O-Ga-N(3) configurations, respectively, on artificial C-O surface dangling bonds by atomic oxygen preirradiation on trilayer graphene. Furthermore, an aluminum nitride (AlN) buffer/interlayer leads to unique metal polarity due to the formation of an AlON thin layer in a growth environment containing trace amounts of oxygen, which explains the open question why those reported wurtzite III-nitride films on 2D materials always exhibit metal polarity. The reported atomic modulation through interface manipulation provides an effective model for hexagonal nitride semiconductor layer grown on graphene, which definitely promotes the development of novel semiconductor devices. This article is protected by copyright. All rights reserved.

In order to increase the critical photon energy, and to save space for accommodating more insertion devices, four normal bend magnets will be replaced by high field ones during the phase-II beamline project of the Shanghai Synchrotron Radiation Facility (SSRF). The design of these superbends has been finished; the first one has been manufactured and measured recently at SSRF. This water-cooled resistive magnet has a total length of 1000 mm and a steering field of 2.32 T. An air slot in the magnet pole was used to control the uniformity of the field integral distribution. The design as well as the magnetic measurement results are presented. Also presented is a newly developed field shimming method, which has been verified as effective and convenient in the field integral shimming of a magnet with straight air slots in the poles.

Lessons Learned Administration of lapatinib with food significantly increased its plasma concentration in Chinese patients with metastatic breast cancer. There were no serious adverse events during the study and no significant differences in lapatinib-related adverse events between the fasted and fed states. Background Lapatinib, a small molecular reversible dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth receptor 2 (HER2), was approved for use in combination with capecitabine to treat metastatic HER2-positive breast cancer. Administration of lapatinib in the fasted state was recommended; however, our preliminary phase II trial data showed that administration of lapatinib with food increased its concentration. Methods This study was a single-center, open-label, and prospective self-controlled clinical study. Ten Chinese patients with metastatic breast cancer were enrolled from June 2017 to April 2018. They were required to receive lapatinib plus physician's choice of chemotherapy. Patients were required to take lapatinib orally on an empty stomach continually for 10 days, and then take lapatinib with food continually for the next 10 days. Plasma concentration was measured by liquid chromatography on the 9th and 10th day of each state. Results Area under the concentration-time curve (AUC) of the fasted state and the fed state was 21.23 ± 8.91 mg*h/L (coefficient of variation (CV)% 42%) and 60.60 ± 16.64 mg*h/L (CV% 27%), respectively. The mean plasma concentration in the fasted state was 0.88 ± 0.39 mg/L (CV% 45%), and that in the fed state was 2.53 ± 0.77 mg/L (CV% 30%). Compared with taking lapatinib on an empty stomach, receiving lapatinib with food significantly increased the plasma concentration of lapatinib (Wilcoxon match-paired test, p = .005). In addition, there were no serious adverse events during the study or significant difference in lapatinib-related adverse events between the two states. Conclusion Our study shows that receiving lapatinib with food can increase its plasma concentration with no significantly increased drug-related toxicity. We suggest that a larger-sample-size clinical trial is needed to fully understand the effect of administration of lapatinib with food.

Menopause is an endocrine-related transition that induces a number of physiological and potentially pathological changes in middle-aged and elderly women. The intention of this research was to investigate the influence of menopause on the intricate relationships between major biochemical metabolites. The study involved metabolic profiling of 186 metabolic markers measured in blood plasma collected from 120 healthy female participants. We developed a method of network analysis using differential correlation that enabled us to detect and characterize differences in metabolites and changes in inter-relationships in pre- and post-menopausal women. A topological analysis was performed on the differential network that uncovered metabolite differences in pre-and post-menopausal women. In this analysis, our method identified two key metabolites, sphingomyelins and phosphatidylcholines, which may be useful in directing further studies into menopause-specific differences in the metabolome, and how these differences may underlie the body's response to stress and disease following the transition from pre- to post-menopausal status for women.

The purpose of this study was to investigate the expression of HNF-1β in various types of epithelial ovarian cancers and to discuss its utilization in the diagnosis of ovarian clear cell carcinoma (OCCC). This study was designed to detect HNF-1β proteins in 27 OCCCs, 35 high-grade serous carcinomas, 21 endometrioid adenocarcinomas, 10 mucinous carcinomas, 2 transitional cell carcinomas, and 13 metastatic Krukenberg tumors by EnVision immunohistochemical system. Twenty-three of 27 (85.2%) OCCCs showed diffuse moderate to strong nuclear staining for HNF-1β. In the 35 high-grade serous ovarian cancers, HNF-1β was detected in 1 (2.9%) case. Five of 21 (23.8%) ovarian endometrioid adenocarcinomas were positive for HNF-1β. Six cases of ovarian mucinous carcinomas displayed diffused moderate to strong nuclear HNF-1β expression, yielding a positive rate of 60%. In the 13 Krukenberg tumors, HNF-1β was detected in 7 cases with a positive rate of 53.8% and both ovary transitional cell carcinomas were negative for HNF-1β transcription factor. Compared with HNF1β expression in OCCCs, serous carcinomas and endometrial adenocarcinomas were significantly lower (P0.01). However, HNF1β expression in mucinous carcinomas and Krukenberg tumors were not significantly different from the expression in OCCCs (P0.05). Using HNF-1β as a diagnostic tool for OCCC showed a sensitivity and specificity of 85.2% and 76.5%, respectively. HNF-1β can serve as an OCCC marker with a relatively high sensitivity. The diffuse and strong HNF-1β expression pattern can be used to diagnose OCCCs with high specificity.

The aim was to investigate the function of fibroblast growth factor receptor 4 (FGFR4) in gastric cancer (GC) and explore the treatment value of agent targeted to FGFR4. Function assays in vitro and in vivo were performed to investigate the discrepancy of biological features among the GC cells with different expression of FGFR4. GC cells were treated with the single and combination of PD173074 (PD, an inhibitor of FGFR4) and 5-fluorouracil (5-Fu). The invasion ability were stronger, and the apoptosis rates were lower in MGC803 and BGC823 cells treated with FGFR4-LV5 (over-expression of FGFR4 protein) (P

Recent theoretical predictions and angle-resolved photoemission spectroscopy measurements have shown that single crystal Cd3As2 is a three-dimensional topological Dirac semimetal possessing linear dispersions along all three momentum directions. Nanoscale topological Dirac semimetal structures have a large surface-to-volume ratio and provide a platform to explore its topological surface states. Here we report the synthesis of high quality Cd3As2 single crystalline nanoplates and nano-octahedrons via a vapor–solid growth mechanism. Triangular and hexagonal nanoplates with lateral dimensions ranging from several hundred nanometers to tens of micrometers are obtained. The top facets are (112), consistent with the natural cleavage plane of Cd3As2 single crystal. The synthesized Cd3As2 nano-octahedrons are enclosed by the {112} facets. A photovoltaic effect is demonstrated from a Cd3As2 nanoplate/metal electrode interface, suggesting potential applications in self-powered photodetection.

Background Duchenne and Becker muscular dystrophy (DMD/BMD) are X-linked recessive disorders caused by mutation in dystrophin gene. We reported 3-year clinic experience from a single hospital in Shanghai using multiplex ligation dependent probe amplification (MLPA) assay to detect DMD mutations. Methods Four hundred and fifty-one males and 184 females, who were clinically diagnosed as DMD/BMD patients or carriers at our hospital's outpatient clinic, were collected and performed with MLPA to detect DMD gene mutations. Results Seventeen novel mutation points not reported in the Leiden Muscular Dystrophy pages were identified in this study. We found that the most frequent deletion spots ranged from exon45 to exon52, and exon2, exon19 were the two most frequently detected duplication spots. Conclusion The results of our study confirmed MLPA as an efficient clinical method for detecting DMD gene mutations in DMD/BMD patients. Single exon mutation detected by MLPA should be verified by other methods, and we should emphasize that only precise clinical molecular diagnosis can lead to the feasibility of prenatal diagnosis.

Lessons Learned Studies targeting the androgen receptor (AR) signaling pathway in aromatase inhibitor (AI)-resistant breast cancer are limited. Bicalutamide, one of the commonly used AR inhibitors in prostate cancer, in combination with AI, did not show synergistic activity in patients with estrogen receptor-positive and AI-resistant disease in this phase II, single-arm study. The clinical benefit rate and objective response rate at 6 months were 16.7% and 0%, respectively, and the study was terminated after the first stage. Background Endocrine resistance is a major problem in clinical practice. Studies have shown that androgen receptor (AR) signaling activation may be one of the mechanisms, and targeting AR showed some promising results in AR-positive triple-negative breast cancer. The aim of this study was to assess the efficacy and safety of bicalutamide plus another aromatase inhibitor in patients with nonsteroidal aromatase inhibitor (AI) or steroidal AI resistance and estrogen receptor (ER)-positive and AR-positive advanced breast cancer. Methods A Simon's two-stage, phase II, single-arm study was conducted. We assumed the clinical benefit rate (CBR) of 40% would be significant in clinical practice. In this case, if ≥4 patients of the 19 patients in the first stage benefited from treatment, the CBR would achieve the assumed endpoint. If fewer than four patients benefited from treatment in the first stage, the trial would be terminated. All patients received bicalutamide 50 mg per day orally plus another aromatase inhibitor. The primary outcome was CBR; secondary outcomes included objective response rate (ORR), progression-free survival (PFS), and tolerability. Results A total of 19 patients enrolled in the first stage, and 18 patients met all criteria for analysis. The trial terminated according to protocol after the first stage. After a median follow-up of 14 months, the CBR at 6 months was 16.7% (3/18); no patients with partial or complete response were observed. The median PFS was 2.7 months. Bicalutamide in combination with AI was well tolerated. Conclusion Bicalutamide in combination with another AI did not show synergistic activity in patients with ER-positive breast cancer and AI resistance. Results suggest that no more large-sample clinical trials should be conducted in this population for overcoming endocrine resistance.

Helium ion microscope (HIM) has presented an outstanding ability to image and nanofabricate thin film and two-dimensional materials with high precision. However, the concomitant damage and implantation induced by focused helium ion beam should influence the imaging quality and nanomachining efficiency inevitably, especially for bulk samples. In this work, the authors investigated the generation process of damages at nanoscales in single crystalline bulk silicon caused by ions implantation in HIM using transmission electron microscopy. The dependence of implantation and damage on ion dose, ion energy, and beam current was also discussed and analyzed. It was found that the damage should be originated from the local defects caused by ion implantation and the crystal structure could be gradually destroyed and transform into amorphous silicon with the generation and growth of subsurface nanobubbles as ion dose increased. The local concentration of implanted helium ion was found as a universal factor to impact on the damage level and the size of nanobubbles directly. These findings not only shed lights on the effective imaging and nanofabrication of HIM but also provide a further understanding in the nuclear irradiation area.Helium ion microscope (HIM) has presented an outstanding ability to image and nanofabricate thin film and two-dimensional materials with high precision. However, the concomitant damage and implantation induced by focused helium ion beam should influence the imaging quality and nanomachining efficiency inevitably, especially for bulk samples. In this work, the authors investigated the generation process of damages at nanoscales in single crystalline bulk silicon caused by ions implantation in HIM using transmission electron microscopy. The dependence of implantation and damage on ion dose, ion energy, and beam current was also discussed and analyzed. It was found that the damage should be originated from the local defects caused by ion implantation and the crystal structure could be gradually destroyed and transform into amorphous silicon with the generation and growth of subsurface nanobubbles as ion dose increased. The local concentration of implanted helium ion was found as a universal factor to impact ...

The front abutment pressure of a fully-mechanized workface of 11061 soft coal isolated island of Liangbei Coal Mine was measured and studied using a self-developed mining-induced stress monitoring system associated with electromagnetic radiation technology, and the effects of abutment pressure distribution on strata behavior we discussed. The results indicate that the mining-induced influencing distance advanced at the fully-mechanized working face of soft coal isolated island is larger than that at the general working face at the isolated island, besides the fracture zone in front of working face was widened to some extent, and the influencing range caused by relaxations on both roadways became bigger with the advancing working face. Moreover, it can be indicated that mining has significant effect on strata behavior of fully-mechanized working face of soft coal isolated island, which is mostly distributed in the area of stress concentration. The research results have an important reference value for revealing the distribution pattern of the front abutment pressure of a fully-mechanized working face of soft coal isolated island, and controlling the coal-rock dynamic disaster occurrence under similar mining conditions. Keywords: Soft coal, Isolated island, Fully-mechanized working face, Abutment pressure, Coal-rock dynamic disaster

In situ epitaxial growth of high-oriented ZnO nanowires on annealed zinc film was realized in an environmental scanning electron microscope. Energy dispersive spectra, X-ray diffraction and photoluminescence measurements demonstrated that a thin layer of [001] ZnO was formed on the surface of zinc film after annealing. Formation of a ZnO layer on annealed zinc film caused dense [001] oriented nanowires compared to the sparse random nanowires grown on unannealed zinc film. Possible growth mechanism for the nanowires grown on annealed and unannealed film was discussed. This work offers a novel approach for effective epitaxial growth of high-oriented ZnO nanowires and helps to understand the growth mechanism of ZnO nanowires.

Y3Fe5O12 (YIG) is a promising candidate for spin wave devices. In the thin film devices, the interface between YIG and substrate may play important roles in determining the device properties. Here, we use spherical aberration-corrected scanning electron microscopy and spectroscopy to study the atomic arrangement, chemistry and electronic structure of the YIG/Gd3Ga5O12 (GGG) interface. We find that the chemical bonding of the interface is FeO-GdGaO and the interface remains sharp in both atomic and electronic structures. We provide an efficient method to study the interface chemical bonding, and these results give necessary information for understanding the properties of interface and also for atomistic calculation.

The influence of surface effects on the temperature dependent photoluminescence (PL) spectra from individual ZnO nanowires has been studied. It is found that the surface effects of the nanowire are very important in both ultraviolet (UV) and visible emission. We propose a new luminescence mechanism based on the recombination related to oxygen vacancies to explain the temperature dependent visible emission, which is significantly influenced by the carrier depletion and band bending caused by surface effects. In addition, the observed attenuation of UV emission with increasing temperature is ascribed to the decreasing depletion region and the increasing surface states related nonradiative recombination.

The current–voltage ( I – V ) characteristics of single ZnO nanowires have been studied in the humid air, dry air, vacuum, and under ultraviolet (UV) irradiation. A model of a single ZnO nanowire connected with two opposite diodes was proposed to calculate the observed I – V behaviors. The results show that the electrical characteristics are dominated by the reverse barrier height, and the barrier height can be adjusted by surface adsorption, which is ascribed to the effect of surface states on surface band bending and Fermi level pining. Furthermore, the nanowire exhibited an enormous increase of conductance upon UV irradiation and a considerable persistent photocurrent after withdraw of the UV excitation, which further confirms the surface states have a pronounced effect on the electronic transport in single ZnO nanowires.

This study demonstrates noninvasive prenatal testing (NIPT) for Duchenne muscular dystrophy (DMD) using a newly developed haplotype-based approach.Eight families at risk for DMD were recruited for this study. Parental haplotypes were constructed using target-region sequencing data from the parents and the probands. Fetal haplotypes were constructed using a hidden Markov model through maternal plasma DNA sequencing. The presence of haplotypes linked to the maternal mutant alleles in males indicated affected fetuses. This method was further validated by comparing the inferred single-nucleotide polymorphism (SNP) genotypes to the direct sequencing results of fetal genomic DNA. Prenatal diagnosis was confirmed with amniocentesis, and those results were interpreted in a blinded fashion.The results showed an average accuracy of 99.98% for the total inferred maternal SNPs. With a mean depth of 30× achieved in the 10-Mb target region of each sample, the noninvasive results were consistent with those of the invasive procedure.This is the first report of NIPT for DMD and the first application of a haplotype-based approach in NIPT for X-linked diseases. With further improvements in accuracy, this haplotype-based strategy could be feasible for NIPT for DMD and even other X-linked single-gene disorders.

Postoperative cognitive dysfunction (POCD) is a frequent complication following major surgery in the elderly. However, the exact pathogenic mechanisms are still unknown. Dexmedetomidine, a selective alpha 2 adrenal receptor agonist, was revealed anesthesia and brain protective role. The present study aimed to examine whether dexmedetomdine protects against POCD induced by major surgical trauma under general anesthesia in aged mice. In the present study, cognitive function was assessed by Y-maze. Proinflammatory cytokines interleukin-1β (IL-1β) and tumor necrosis factor (TNF-α), apoptosis-related factor caspase-3 and Bax were detected by real-time PCR, Western blot or immunohistochemistry. The results showed that anesthesia alone caused weak cognitive dysfunction on the first day after general anesthesia. Cognitive function in mice with splenectomy under general anesthesia was significantly exacerbated at the first and third days after surgery, and was significantly improved by dexmedetomidine administration. Splenectomy increased the expression of IL-1β, TNF-α, Bax and caspase-3 in hippocampus. These changes were significantly inversed by dexmedetomidine. These results suggest that hippocampal inflammatory response and neuronal apoptosis may contribute to POCD, and selective alpha 2 adrenal receptor excitation play a protective role.

Collaboration between logistics provider and manufacturer is the necessary condition to improve the overall competitiveness of a supply chain. However, collaboration disrupts from time to time due to poor weather, natural and man-made disasters, or a combination of any other factors. The unplanned disruption can cause a production delays, the cost leaps, and even the company bankrupts. The purpose of this paper is to examine the use of strategies to reducing risks, which may lead to a collaboration disruption between logistics provider and manufacturer. Based on the related mathematical theory and the theory of economics respectively, this paper develops a model that can be used to identify the response that can lead to obtain optimum results for logistics provider and manufacturer. Based on the model, managers for both sides can develop appropriate strategies for reducing risk exposures in the event of a collaboration disruption.

This paper studies the ordering strategy for retail companies in the two-stage supply chain for perishable products consisting of a retailer and a risk-neutral supplier under option contracts. Through building the total profit model and the retailer profit model in the supply chain under option contracts, retailers' ordering policy and suppliers' pricing strategy are obtained when the supply chain profit is optimal. The retailer's attitude towards risk directly influences its ordering decisions, the paper takes the retailer's attitude to risk into consideration and use conditional risk value to measure the retailer's risk aversion. It is shown that the optimal fixed order quantity depends on the spots wholesale price, the option purchasing price, the option striking price and the coefficient of risk aversion of retailers jointly.

The level of inventory control is directly related to clothing sales business survival and development. This paper analyzes the characteristics and inventory issues of clothing sales business such as: low inventory turnover, serious backlog of inventory and structural imbalance and its causes. On this basis, we study inventory control specific strategy of the clothing sales business from procurement, distribution to sales.

The rise and development of the service industry depend on the competitiveness of service enterprises, and service innovation is the source and power of the competitiveness of enterprises. In this paper, knowledge management theory is quoted to explain the formation of service innovation, and then it takes the value chain theory as a research perspective, through an analysis of the value chain of service enterprises, builds a service innovation system of service business, and finally takes a performance evaluation of service innovation.

Today, the disproportional distribution of water resources becomes a restrictive factor for sustainable development of Chinese national economy. Therefore, Chinese government has implemented numerous Inter-basin water diversion projects. However they are complicated and systemic engineering projects which consist of many facilities with longer delivery route, involutedly transit area and multitudinous impact factors. This paper studies the management model of inter-basin water diversion based on multi-intelligent agents which regards the management department of facility as agent and takes its goals and function demands into account. First, the paper studies the water delivery framework of distributed inter-basin water diversion project, and analyzes the types and distribution of the intelligent agent and model of communication, interaction and cooperation so that automation, convenient and intelligence of inter-basin water diversion can be realized. Then, it researches the inner structures of all kinds of intelligent agents, and discusses simultaneously the mechanism of knowledge expression and self-training.

The current-voltage (I-V) characteristics of single ZnO nanowires were measured varying with temperature and illumination. A model of the ZnO nanowire sandwiched by back-to-back diodes was utilized to explain the experimental data. Simulations of the I-V curves exhibited that the surface barrier height was independent of temperature from 180 to 290 K. This work also shows that the larger the incident laser power is, the smaller the contact surface barrier height will be. The photon induced reduction in the surface barrier height is attributed to the photogenerated holes, which result in a shielding effect on the surface trapped electrons.

Satisfiability (SAT) problem is an NP-complete problem. Based on the analysis about it, SAT problem is translated equally into an optimization problem on the minimum of objective function. A hybrid differential evolution algorithm is proposed to solve the Satisfiability problem. It makes full use of strong local search capacity of hill-climbing algorithm and strong global search capability of differential evolution algorithm, which makes up their disadvantages, improves the efficiency of algorithm and avoids the stagnation phenomenon. The experiment results show that the hybrid algorithm is efficient in solving SAT problem.

The project management is the important branch under the management science, it specialized the most important teaching profession that is quality of teaching, which has formed this article. This article unifies the project management talented person's knowledge level which full scale development request, and considers that after this college major come on the line post, the undergraduate course stage's quality of teaching was not only deciding the school prestige, but also deciding them for the social service level. Therefore, this article gave the necessity of the proof project management and put forward several proposals to improve the quality of teaching.

The characteristic of Chinapsilas project in Market economy system initial period has decided that the project operating condition and the project decision-making condition has the strong coupling. On one hand, the project operating level's enhancement can affect the choice of the project decision-making management pattern; On the other hand, decision model's evolution will also promote the project management level enhancement. Therefore, we should grasp the relations between the operating condition and the policy-making condition from the coupling, and should pay attain to impetus project management pattern evolution, which focuses on researching on project decision-making condition and operating condition, then comprehensive promotes project management achievements.

The recent rush towards electronic commerce over the Internet raises many challenges, this paper present a simple model of supply chains. First a model of supply chains is discussed, highlighting two characteristic features: hierarchical subtask decomposition, and resource contention. Then a market protocol based on distributed but concurrent auctions is proposed. The protocol allow each of these markets to function separately, while the information exchanged between a sequence of markets along a single supply chain to ensure efficient global behavior across the supply chain. Each market that forms a link in the supply chain operates as a double auction, where the bids on one side of the double auction come from bidders in the corresponding segment of the industry, and the bids on the other side are synthetically generated by the protocol to express the combined information from all other links in the chain.

Asymmetric Schottky barriers between ZnO nanowire and metal electrode have been fabricated at the two ends of the nanowire. An obvious photocurrent generated from the device at zero voltage bias can be switched on/off with quick response by controlling the light irradiation. Moreover, the device can still afford a current at zero bias after switching off light illumination, which is ascribed to the charge storage effect in single ZnO nanowires. The underlying mechanisms related to the photovoltaic effect and charge storage were discussed.

We studied the influence of adsorbates on the space-charge-limited current (SCLC) in individual ZnO nanowires through varying the bias voltage, laser illumination, and ambient pressure. In dark and air conditions, the free carriers were depleted by the surface adsorbates, and electrons injected from the electrode to the nanowire dominated the electron transport properties. Under laser illumination, the current-voltage characteristic was linear at low voltage and superlinear at high voltage, and the SCLC regime occurred at high voltages due to the surface desorption. The time response of photoconductivity further revealed the dynamic process of elimination of SCLC by desorption of oxygen molecules at the ZnO nanowire surface.