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Eosinophilic pleural effusion (EPE) is defined as a pleural fluid with an eosinophilic count exceeding 10% and currently considered to be mainly caused by malignancy. However, the incidence, etiology and prognostic significance of malignant eosinophilic pleural effusion (MEPE) have not been studied extensively yet. Thus, the objective of this review was to summarize medical studies regarding MEPE to 2020 throughout an extensive search of PubMed. Overall, MEPE was a disease associated with multiplecytokines-mediated immunity and varied from 4% to 92% of patients who had EPE. The discrepancy of the MEPE prevalence among studies could be explained by the development of diagnostic technology, disparity of study population, or various disease spectrum over time. Data summarized in this review demonstrated that the incidence of malignancy was lower in EPEs than in non-EPEs (29.7% vs. 32.9%). Additionally, MEPE could be a manifestation of a great variety of tumor subtypes, among which lung cancer was the most common cause and accounted for more than 34% of cases. The second common causes were non-Hodgkin lymphoma and metastatic cancers with unknown primary site which were observed in around 5% of cases, respectively. The presence of eosinophils in the pleural effusion may be associated with a positive prognosis of MEPE. Besides, the prognosis of MEPE may be related to the percentage of eosinophils in the pleural fluid. More extensive studies, however, are warranted to validate these findings.

Purpose. The aim of the present study was to analyze the clinical characteristics of visual dysfunction in patients with carbon monoxide (CO) poisoning. Methods. A total of 436 patients with CO poisoning were enrolled in our hospital from October 2012 to December 2018, including 193 patients with moderate poisoning (MP group), 165 with severe poisoning (SP group), and 78 with delayed encephalopathy (DE group). The clinical characteristics of visual dysfunction in patients with CO poisoning were analyzed through the collection of medical history, regular physical examination, brain magnetic resonance imaging (MRI), ophthalmological examination, the National Eye Institute Visual Function Questionnaire (NEI-VFQ), and its influencing factors. Results. Some patients in the three groups had visual dysfunction. The main ocular symptoms were local pain, eye movement disorder, and visual field defect. The key pathological factors were keratopathy, retinal nerve cell damage, optic nerve damage, retinal vascular disease, macular disease, and occipital visual center damage. The clinical symptoms of visual dysfunction after CO poisoning lasted for a long time (>12 months) and were not completely consistent with the positive results of the ophthalmological examination. A few sequelae of ophthalmology were still left after the help of medicine. Conclusion. The incidence of visual dysfunction in patients with CO poisoning was high, the clinical symptoms were rich and diverse, the duration of disease was long, and the prognosis was poor. Thus, the relevant ophthalmological examination and intervention treatment should be perfected as soon as possible.

Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients.We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death.The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission.During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.).

In this paper, we present our implementation and evaluation of multi-node transmission over Content Centric Networking, which is realized by CCNx project. As there are no client-server connections in CCN, it offers the possibility to transfer data from multiple nodes as well as multiple links in parallel. However, in the current strategy of CCNx, even if there are many nodes who store the video files the client needs, the CCNx may choose one node to transfer the resource at one point, resulting the waste of other links .Thus we try to split video files into fragments. Multi-nodes will cooperate together to transfer the fragments As there are more than one nodes transferring the different fragments at the same time, each link can be made fully used and the transfer performance can be improved in some ways.

The upregulated expression of JMJD6 was observed in various human cancers. However, little was known about JMJD6 expression and its clinicopathological significance in lung adenocarcinoma. The aim of this study was to investigate the expression and significance of JMJD6 in lung adenocarcinoma progression and prognosis. The levels of JMJD6 mRNA and protein in lung adenocarcinoma specimens and corresponding non-tumorous lung tissues were evaluated by quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and Western blot. In order to investigate the correlations between JMJD6 and the clinicopathological features of lung adenocarcinoma, the expression of JMJD6 in 154 patients with lung adenocarcinoma was detected by immunohistochemistry. By qRT-PCR and Western blot, the relative expression levels of JMJD6 mRNA and protein were significantly higher in lung adenocarcinoma tissues than in corresponding non-tumorous lung tissues (P

In winter, aircraft icing or frost is serious potential accident for flight safety which needs equipment to deice. However, until now, there have been no relevant manufacturing enterprise and technology at home. According to design requirements of aircraft deicing vehicle and firing boiler, through comparative analyses of various designs at home and abroad, operating scheme and key devices of deicing system were designed, including deicing firing boiler and hydraulic burner system. Finally a hydraulic oil-fired deicing system suitable for aircraft deicing vehicle was developed successfully. New deicing system and firing boiler have the advantages of reasonable design, reliable working, economic usefulness and convenient operation, which meet the design requirements and fill in the domestic blank. The products not only can be applied in domestic airports but also in civil fields, being of important innovative and practical significance.

Navigation light monitoring system is designed to detect the working condition of each light with circuit cable carrier. However, the real-time detecting information could be inaccurate as a result of the existence of disturbances such as noise, multi-path effect and channel decline, when the data transmission happens in light cable as the channel. In this paper, OFDM (Orthogonal Frequency Division Multiplexing) is presented to be used in circuit cable communication. And the reason and capability of the resistance to these disturbances in OFDM are analyzed. Finally, the result is concluded that OFDM used in navigation light cable channel is feasible.

The basic idea of twice genetic algorithm optimization of BP neural network model(TGB)is rough selection network model using genetic algorithm, then use BP neural network to determine the parameters which can make the error function obtained the minimum and determine its position in the parameter space, then the genetic algorithm again to solve the problem of possible local minima.Feature selection is a new formulation of dimension reduction methods. It can simplify the size of neural network and improve real-time and the accuracy of the system.The simulation results TGB-based network intrusion detection algorithm improve intrusion detection rate of samples in different degrees. It can reduce significantly training time and test time. It further demonstrates the effectiveness and feasibility of this method. The study is very useful to detect materials. So from the analysis, you can learn some skills for materials detecting.

Studying technology of feature analysis, a new method of feature selection based on self -reacting feature weighted is presented, and it is applied into the intrusion feature selection with the technique of feature selection and the technique of SVM classification combined. The method can reduce the time complexity and space complexity with the situation of parameter trying improved. The experiment results show that the detection precision rises obviously, meanwhile, the training time and the test time are also improved variously. The model has the ability to respond quickly with the accuracy and real-time performance of the Intrusion Detection System improved effectively. So, the method can be extended significantly.

The objective of this paper is double layer competition sports flooring. The orthogonal regression experiments were carried out in order to establish the regression equations between keel structral influence factors (keel siding, keel thickness, keel spacing) and property indexes of sports flooring (force reduction rate Fr, standard vertical deformationVd, ball rebound rate Br). Through SPSS analysis method it find that factors and factor interaction have significant effect on Fr,Vd and Br respectively at a 95% or above confidence level. Then the regression equations of each experimental index are established and the optimum factor combinations are found out. After balancing the three experimental indexes, this paper concludes the comprehensive optimum keel structural parameters for whole property which are the span keel spacing 500mm×500mm, keel cross section 50mm×50mm. The regression equations show the statistical relationship between keel structure and property. They can be directly applied to assist the design, production procedure of keel and the field installation of sports flooring.

This paper addresses the problem of large scale content-based video retrieval with relevance feedback. We analyze the common methods which leverage local feature detectors to extract feature descriptors from video collections and perform multi-level matching after indexing and retrieval of feature vectors. Instead of learning similarity-preserving codes, an approach of relevance feedback in a light-weight way is proposed. A relevance model is proposed to merge semantic similarity with the original distance matching at descriptor level. By learning several weights using canonical correlation analysis (CCA), the resulting candidate list of similar videos changes according to relevance feedback. Finally, we demonstrate the improvement of the proposed method by experiments on a standard real world dataset.

The purpose of this study was to assess ADAM17 expression and to explore its contribution to the non-small cell lung cancer (NSCLC). Real-time quantitative reverse transcriptase-polymerase chain reaction was conducted to detect ADAM17 mRNA expression. In addition, ADAM17 expression was analyzed by immunohistochemistry in 124 clinicopathologically characterized NSCLC cases. The correlation of ADAM17 expression with patients' survival rate was assessed by Kaplan-Meier and Cox regression. The expression levels of ADAM17 mRNA and protein in NSCLC tissues were both significantly higher than those in non-cancerous tissues. In addition, high expression of ADAM17 was significantly correlated with tumor grade (P=0.026), tumor size (P=0.001), clinical stage (P=0.016), and lymph node metastases (P

We have conducted three studies to examine the role of TNFalpha in islet destruction in female nonobese diabetic mouse (NOD) mice, a model of human autoimmune diabetes, using polyethylene glycolated (PEGylated) soluble TNF receptor type I (PEG sTNF-RI) as TNFalpha antagonist. PEG sTNF-RI (3 mg/kg, sc) was given every other day to NOD mice from age wk 8 for 12 wk (study 1), from age wk 12 for 8 wk (study 2), or from age wk 8 for 3 wk, with cyclophosphamide (6 mg/mouse) injected at wk 9 to accelerate the onset of diabetes (study 3). Diabetic incidence was reduced (control vs. PEG sTNF-RI) from 68.7% (11 of 16) to 18.3% (3 of 16) in study 1, from 84.6% (11 of 13) to 28.5% (4 of 14) in study 2, and from 66.6% (8 of 12) to 23.1% (3 of 13) in study 3, respectively. The incidence of insulitis was also reduced from 91.6% (11 of 12) to 12.5% (2 of 16) in study 1 and from 100% (7 of 7) to 16.6% (2 of 12) in study 2 by PEG sTNF-RI. PEG sTNF-RI also largely preserved islet insulin content, reduced mRNA of inducible nitric oxide synthase and IL-6 in pancreases, and lowered plasma corticosterone, glycerol, and free fatty acid levels. These results confirm a pathogenic role of TNFalpha in mediating insulitis in NOD mice and suggest the prophylactic and therapeutic potential of PEG sTNF-RI for human autoimmune diabetes.

We examined a possible mechanistic interaction between leptin and thyroid hormones in rats with hypothyroidism induced by thyroidectomy (TX) and propylthiouracil administration. In study 1, the TX rats were treated by vehicle (V, n = 9) or by recombinant murine leptin (L, 0.3 mg · kg−1 · day−1, n = 9) or were pair-fed (PF, n = 9) against L. In study 2, the TX rats were all given 3,3′5′-triiodo-l-thyronine (T3) replacement (T, 5 μg · kg−1 · day−1) to correct hypothyroidism. They were then subdivided into three groups, namely, vehicle (T+V, n = 9), leptin (T+L, n = 10), and pair-feeding (T+PF, n = 9), similar to study 1 except for T3 (T). Reduced food consumption and weight gain in the TX rats were reversed by T3 replacement. Leptin suppressed food intake in the TX rats regardless of T3 replacement. O2consumption (V˙o 2) and CO2production (V˙co 2) were reduced in TX rats ( P < 0.05 vs. normal) but were normalized by either T3 or leptin treatment. T+L additively increasedV˙o 2 andV˙co 2 ( P < 0.05 vs. TX, T3, and L). The respiratory exchange ratio was unaltered in TX rats, with and without T3, but was significantly reduced by L or T+L treatments. These results indicate that the metabolic actions of leptin are not dependent on a normal thyroid status and that the effects of leptin and T3 on oxidative metabolism are additive.