1. Detection of functional and structural brain alterations in female schizophrenia using elastic net logistic regression
- Author
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Rong Chen, Wentao Jiang, Jianxing Xu, NianSheng Tang, Xia Liu, Hong Xu, Ying Wu, Lin Zeng, Donghui Wu, and Ping Ren
- Subjects
Elastic net regularization ,medicine.medical_specialty ,Cognitive Neuroscience ,Schizophrenia (object-oriented programming) ,Audiology ,Logistic regression ,03 medical and health sciences ,Behavioral Neuroscience ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Neuroimaging ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Neuroradiology ,Brain Mapping ,medicine.diagnostic_test ,business.industry ,Neuropsychology ,Brain ,Magnetic Resonance Imaging ,030227 psychiatry ,Psychiatry and Mental health ,Logistic Models ,Neurology ,Schizophrenia ,Female ,Neurology (clinical) ,Abnormality ,business ,Functional magnetic resonance imaging ,human activities ,030217 neurology & neurosurgery - Abstract
Neuroimaging technique is a powerful tool to characterize the abnormality of brain networks in schizophrenia. However, the neurophysiological substrate of schizophrenia is still unclear. Here we investigated the patterns of brain functional and structural changes in female patients with schizophrenia using elastic net logistic regression analysis of resting-state functional magnetic resonance imaging data. Data from 52 participants (25 female schizophrenia patients and 27 healthy controls) were obtained. Using an elastic net penalty, the brain regions most relevant to schizophrenia pathology were defined in the models using the amplitude of low-frequency fluctuations (ALFF) and gray matter, respectively. The receiver operating characteristic analysis showed reliable classification accuracy with 85.7% in ALFF analysis, and 77.1% in gray matter analysis. Notably, our results showed eight common regions between the ALFF and gray matter analyses, including the Frontal-Inf-Orb-R, Rolandic-Oper-R, Olfactory-R, Angular-L, Precuneus-L, Precuenus-R, Heschl-L, and Temporal-Pole-Mid-R. In addition, the severity of symptoms was found positively associated with the ALFF within the Rolandic-Oper-R and Frontal-Inf-Orb-R. Our findings indicated that elastic net logistic regression could be a useful tool to identify the characteristics of schizophrenia -related brain deterioration, which provides novel insights into schizophrenia diagnosis and prediction.
- Published
- 2021
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