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Optical imaging systems are used extensively in the life and physical sciences because of their ability to non-invasively capture details on the microscopic and nanoscopic scales. Such systems are often limited by source or detector noise, image distortions and human operator misjudgement. Here, we report a general, quantitative method to analyse and correct these errors. We use this method to identify and correct optical aberrations in an imaging system for single atoms and realize an atomic position sensitivity of ∼0.5 nm Hz−1/2 with a minimum uncertainty of 1.7 nm, allowing the direct imaging of atomic motion. This is the highest position sensitivity ever measured for an isolated atom and opens up the possibility of performing out-of-focus three-dimensional particle tracking, imaging of atoms in three-dimensional optical lattices or sensing forces at the yoctonewton (10−24 N) scale. The position of a single Yb atomic ion is determined with a minimum uncertainty of 1.7 nm for 0.2 s integration time — the highest position sensitivity reported to date for an isolated atom.

WormBase (http://www.wormbase.org/) is a highly curated resource dedicated to supporting research using the model organism Caenorhabditis elegans. With an electronic history predating the World Wide Web, WormBase contains information ranging from the sequence and phenotype of individual alleles to genome-wide studies generated using next-generation sequencing technologies. In recent years, we have expanded the contents to include data on additional nematodes of agricultural and medical significance, bringing the knowledge of C. elegans to bear on these systems and providing support for underserved research communities. Manual curation of the primary literature remains a central focus of the WormBase project, providing users with reliable, up-to-date and highly cross-linked information. In this update, we describe efforts to organize the original atomized and highly contextualized curated data into integrated syntheses of discrete biological topics. Next, we discuss our experiences coping with the vast increase in available genome sequences made possible through next-generation sequencing platforms. Finally, we describe some of the features and tools of the new WormBase Web site that help users better find and explore data of interest.

Hybrid quantum systems can be formed that combine the strengths of multiple platforms while avoiding the weaknesses. Here we report on progress toward a hybrid quantum system of neutral atom spins coupled to superconducting qubits. We trap laser-cooled rubidium atoms in the evanescent field of an ultrathin optical fiber, which will be suspended a few microns above a superconducting circuit that resonates at the hyperfine frequency of the Rb atoms, allowing magnetic coupling between the atoms and superconductor. As this will be done in a dilution refrigerator environment, the technical demands on the optical fiber is severe. We have developed and optimized a tapered fiber fabrication system, achieving optical transmission in excess of 99.95% , and fibers that can sustain 400 mW of optical power in a UHV environment. We have also optimized tapered fibers that can support higher order optical modes with high transmission (> 97%), which may be useful for different optical potential geometries. We have developed an in-situ tunable high-Q superconducting microwave resonator that can be tuned to within the resonator linewidth of the 6.8 GHz frequency of the Rb hyperfine transition.

We present an experimental and theoretical study of the energy transfer between modes during the tapering process of an optical nanofiber through spectrogram analysis. The results allow optimization of the tapering process, and we measure transmission in excess of 99.95% for the fundamental mode. We quantify the adiabaticity condition through calculations and place an upper bound on the amount of energy transferred to other modes at each step of the tapering, giving practical limits to the tapering angle., Comment: 29 pages, 17 figures

We present a procedure for reproducibly fabricating ultrahigh transmission optical nanofibers (530 nm diameter and 84 mm stretch) with single-mode transmissions of 99.95 $ \pm$ 0.02%, which represents a loss from tapering of 2.6 $\,\times \,$ 10$^{-5}$ dB/mm when normalized to the entire stretch. When controllably launching the next family of higher-order modes on a fiber with 195 mm stretch, we achieve a transmission of 97.8 $\pm$ 2.8%, which has a loss from tapering of 5.0 $\,\times \,$ 10$^{-4}$ dB/mm when normalized to the entire stretch. Our pulling and transfer procedures allow us to fabricate optical nanofibers that transmit more than 400 mW in high vacuum conditions. These results, published as parameters in our previous work, present an improvement of two orders of magnitude less loss for the fundamental mode and an increase in transmission of more than 300% for higher-order modes, when following the protocols detailed in this paper. We extract from the transmission during the pull, the only reported spectrogram of a fundamental mode launch that does not include excitation to asymmetric modes; in stark contrast to a pull in which our cleaning protocol is not followed. These results depend critically on the pre-pull cleanliness and when properly following our pulling protocols are in excellent agreement with simulations., Comment: 32 pages, 10 figures, accepted to AIP Advances