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espanolIntroduccion: la sedacion mejora sensiblemente la calidad de la endoscopia digestiva, aunque puede tener complicaciones graves. Metodos: protocolo multidisciplinar en base a la joint comission que defina el protocolo de sedacion por no anestesiologos. Se excluyen pacientes ASA 4 o con via aerea dificil, pruebas complejas y sedacion profunda. Controlamos la calidad en base al analisis de 9 indicadores. Tambien se monitorizan las pruebas incompletas para valorar eficacia. Resultados: la seguridad del paciente se establece en base a una incidencia de complicaciones muy baja, con una incidencia de eventos respiratorios de 1,07. Ademas, se encuentra una baja incidencia de hipotension y bradicardia, al igual que del dolor durante y despues de la endoscopia y una incidencia menor del 0,5% de ingresos no esperados. Los indicadores de calidad medidos nos indican la evolucion de los resultados del programa. Conclusiones: la monitorizacion continuada de los programas de sedacion en endoscopia permiten controlar las diferentes dimensiones de la calidad e implementar medidas que mejoren el proceso. EnglishIntroduction: sedation substantially improves the quality of digestive endoscopy procedures but may result in severe complications. Methods: a joint commission-based multidisciplinary protocol was used to define a protocol for sedation by non-anesthesiologists. ASA 4 patients were excluded, as well as patients with a difficult airway, complex procedures and deep sedation. Quality based on the analysis of 9 indicators were monitored. Incomplete procedures were also monitored in order to assess efficacy. Results: patient safety was established based on a very low incidence of complications and a rate of respiratory events of 1.07. Furthermore, a low rate of hypotension and bradycardia was found, as well as a low rate of pain, either during or after endoscopy and an incidence of unexpected admissions lower than 0.5%. The quality indicators measured reflect the evolution of the results of the program. Conclusions: ongoing sedation program monitoring in endoscopy allows the control of different quality dimensions and the implementation of steps for process improvement.

Stevia rebaudiana Bertoni is a herb common to tropical and subtropical regions particularly Asia and South America. In countries like Malaysia, the sweet leaves of this plant have been used in daily cooking and as a form of alternative therapy by communities practicing folk medicines. The zero-calorie value of stevia leaves also provide a beneficial sweetening alternative to patients with metabolic syndromes like diabetes and obesity. A cell culture model of 3T3-L1 pre-adipocytes was implemented in this study to investigate the effects of stevioside, a major component extracted from the S. rebaudiana Bertoni plant on improving insulin sensitivity. 3T3-L1 pre-adipocytes were first differentiated to mature adipocytes prior to tests. The differentiation process was later confirmed by performing Oil Red-O staining. The degree of insulin sensitivity was measured by performing counts via the radioactive 2-deoxy-(1- 3 H)-glucose uptake assay. A separate assay was done to estimate the optimum insulin concentration in the glucose uptake of the 3T3-L1 adipocytes. Cells treated with stevioside showed significant increase in glucose uptake at lower concentrations compared to a diabetic drug, rosiglitazone maleate at higher concentrations of the compound. The enhancement of glucose uptake was 2.08-fold (p