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The article presents the results of a study of the effect of prolonged Alflutop therapy on the arthrosonographic changes in knee joints (sizes of articular cartilage, joint space width, severity of osteophytic disease, local inflammation activity) in patients with gonarthritis. The treatment was prescribed to patients in the early stages of the disease and repeated by regular courses. It was found that prolonged therapy with Alflutop slows down the articular cartilage degradation, the progression of structural changes in knee joints, the local inflammation activity (according to arthrosonography), which reduces the symptoms of osteoarthritis and improves the patient’s quality of life.

Two hundred and forty-four outpatients with gonarthrosis were examined. The time course of arthrosonographic (the height of the articular cartilage, the volume of intraarticular effusion, the width of the joint cleft, and the degree of osteophytosis) changes were estimated during longterm Teraflex therapy and in control patients. The long-term (3-year) Teraflex therapy was shown to have a restraining impact on the processes of articular cartilage degradation and the progression of articular structural changes and to exert an anti-inflammatory effect.