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Therapeutic efficacy of the plant neuroprotector Phytomix-40 in Parkinson's disease was demonstrated. This preparation consists of the components from extracts of 40 plants, including some adaptogens (ginseng, eleutherococcus, Rhodiola rosea, etc.). The preparation normalized immune, antioxidant, and hormonal parameters in patients. The neuroprotective plant adaptogen can be used in complex therapy for Parkinson's disease for improving its efficacy.

untington’s disease (HD) is one of the most severe and fatal hereditary diseases of the nervous system. The paper outlines the history of studies of the disease, its key features and development mechanisms in terms of recent advances in molecular biology. The neuropsychiatric manifestations of HD, which are a major disabling factor, are characterized. Mental and emotional-volitional disorders are systematized; possible methods for correction of the clinical manifestations of HD are presented. A special emphasis is made on the fact that cooperation between different specialists and with a patient’s relatives is of importance in achieving the best treatment results. The authors present their experience in studying the psychopathological manifestations of HD at the Neurology Research Center, Russian Academy of Medical Sciences, and the results of an integrated study of cognitive and neuropsychological characteristics of at-risk asymptomatic HD gene carriers, by using a battery of psychological tests and the newest methods of electroneurophysiology and neuroimaging, and conclude that there is a preclinical disease stage. The authors’ experience with pharmacotherapy for neuropsychiatric manifestations and cognitive deficit in HD patients is described.

The authors have developed a new method of computerized statistical analysis of the spectral parameters of the circumscribing electromyogram in patients with essential tremor (ET), making use of objective frequency and amplitude parameters. The results have shown that ET differed from physiological tremor not only by amplitude but also by frequency characteristics. Four groups of patients have been identified which differed in relation to both parameters. Clear-cut criteria have been defined which may be used in the differential diagnosis between ET and parkinsonism-associated tremor. It has been suggested that the pathological mechanisms of ET and parkinsonism-associated tremor differ in their location.