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Objective To evaluate the accuracy of the YuWell YE900 oscillometric upper-arm professional office blood pressure monitor in adults and children according to the Association for the Advancement of Medical Instrumentation/European Society of Hypertension/International Organization for Standardization (AAMI/ESH/ISO) Universal Standard (ISO 81060-2:2018). Methods Subjects were recruited to fulfill the age, sex, blood pressure and cuff distribution criteria of the AAMI/ESH/ISO Universal Standard in adults and children (aged 3-12 years) using the same arm sequential blood pressure measurement method. Three cuffs of the test device were used for arm circumference 18-22 cm (small), 22-32 cm (medium) and 32-42 cm (large). Results Ninety-two subjects were recruited, and 85 (50 adults and 35 children) were analyzed. For validation criterion 1, the mean ± SD of the differences between the test device and reference blood pressure readings was 1.7 ± 6.62/3.1 ± 5.76 mmHg (systolic/diastolic). For validation criterion 2, the SD of the averaged blood pressure differences between the test device and reference blood pressure per subject was 5.25/5.13 mmHg (systolic/diastolic). Conclusion The YuWell YE900 professional electronic blood pressure monitor has passed the requirements of the AAMI/ESH/ISO Universal Standard (ISO 81060-2:2018) in adults and children and can be recommended for clinical use.

Ferrotitanium is used as a deoxidizer and alloying agent during steelmaking process, which has a high demand for sulfur control. Sulfur was introduced from raw materials in the process of producing ferrotitanium by thermite method, where CaO was used as fluxing agent. At the same time, CaO has a great desulfurization capability. Effects of CaO addition on the distribution of sulfur in high titanium ferroalloy prepared by thermite method were studied in this work. The equilibrium diagram of Ti–Al–Fe–S system was calculated by FactSage 6.4 software package with FactPS and FTmisc database. The alloy and slag samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), inductively coupled plasma atomic emission spectrometer (ICP-AES), X-ray fluorescence (XRF) and high-frequency infrared ray carbon sulfur analyzer. The result indicates that the sulfur in the alloy firstly exists in the form of liquid FeS, thereafter TiS (s) and eventually Ti2S (s) during cooling. The sulfur is mainly distributed in the alloy, and only a small amount of sulfur remains in the slag. Moreover, it is noted that the sulfur in the alloy does not distribute homogeneously, and it exists in the form of solid solution phase, (Ti, Al, Fe)S. S content in the slag, the sulfur capacity of the slag and the sulfur distribution ratio (LS) all increase with the increment of CaO addition, while S content in alloys decreases.

Ectopic thoracic kidneys are the rarest form of renal ectopia. Moreover, congenital abnormality of a primary anterior inferior vena cava (IVC) located behind the anterior abdominal wall is extremely rare. To date, only one such case has been reported. Herein, we report a rare case of a 55-year-old Chinese male with bilateral thoracic kidneys combined with an anterior IVC, a malformed liver, and a large-round-folds navel. The classification, clinical characteristics, and management options of a thoracic kidney was also summarized by literature review. To our best knowledge, the simultaneous detection of such multiple complex abnormalities has not been reported.

Background: To investigate the epidemiologic features of breast cancer laterality and molecular subtypes in Southern China, we retrospectively analyzed the clinical data of patients with a definite diagnosis of breast cancer in 2013-2017. Methods: Data for inpatient hospitalization associated with breast cancer were obtained from the Affiliated Hospital of Guangdong Medical University, Guangdong Province, South China. Around 2060 cases who were diagnosed with unilateral breast cancer for the past 5 years were classified based on laterality and molecular subtypes. Molecular subtypes were defined in accordance with the 2013 St. Gallen recommendations. All statistical analyses were performed using Statistical Product and Service Solutions version 21 and Excel version 2010. Results: Breast cancer is more likely to be diagnosed in the left breast than in the right by around 5%. In both in situ and invasive carcinomas, the right breast is more commonly affected than the left in young (

This research has analysed the entire construction data monitored from the largest constructed underground water-sealed oil storage cavern in China using time series analyses (auto-correlation and cross-correlation models) to access the functional efficiency of its water curtain system. For large-scale projects, data monitoring is the best method to assess the variation rules of the project. Specifically, a dataset of hydrologic time series were collected first, including the water supply of the water curtain system, the water inflow of the caverns, and the underground water level in different monitoring boreholes. The methods of auto-correlation and cross-correlation were then adapted to process the above three datasets to evaluate the functional efficiency of the water curtain system. It was concluded that setting the water curtain system in a traditional manner in an area with heavy rainfall leads to low-functional efficiency. Finally, the water-sealed efficiency and the optimised setting of a water curtain system were discussed. The results of the study provide new insights into the function of the water curtain system, and could constitute the basis for the optimisation of the water curtain system in an area with heavy rainfall.

// Liang Jiang 1 , Gao-Le Yuan 1 , Qi-Lian Liang 1 , Hui-Jie Zhang 1 , Jie Huang 1 , Shao-Ang Cheng 1 and Xiao-Xia Peng 1 1 Oncology Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China Correspondence to: Qi-Lian Liang, email: // Keywords : YB-1, NSCLC, IHC, prognosis, meta-analysis Received : October 08, 2016 Accepted : January 10, 2017 Published : January 18, 2017 Abstract Background: Y-box binding protein 1 (YB-1) belongs to the cold shock domain protein family involved in transcription and translation. We conducted a meta-analysis of the association between YB-1 expression and the survival and clinicopathological features in NSCLC. Methods: PubMed and Embase were searched to identify studies that evaluated the YB-1 expression (by immunohistochemistry) and overall survival (OS) in NSCLC. Hazard ratios (HRs) and 95% confidence intervals (CI) of OS were pooled. Odds ratios (ORs) of clinicopathological features were computed. Meta-analysis was performed using STATA 12.0 software. Results: Data on 692 NSCLC patients were collected from six eligible studies. Meta-analysis revealed that YB-1 was associated with worse OS (HR = 1.59, 95% CI [1.27, 2.00], P < 0.001, fixed effect), tumor stage (OR = 0.43, 95% CI [0.22-0.82], P = 0.01, random effect), and depth of invasion (OR = 0.37, 95%CI [0.22-0.63], P < 0.001, fixed effect). A subgroup was analyzed by IHC staining to determine the location of YB-1 positive expression. Poor OS was observed in nucleus staining (pooled HR = 1.86, 95% CI [1.41, 2.45], P < 0.001). However, no statistical significance was observed in combined cytoplasmic and nuclear staining (pooled HR = 1.14, 95% CI [0.76, 1.72], P = 0.536). Conclusions: Meta-analysis indicated that YB-1 overexpression is correlated with worse OS and clinicopathological features in NSCLC. Subgroup analysis revealed that the nucleus expression of YB-1 may be more closely associated with NSCLC prognosis than cytoplasmic expression.

In this special issue of Genes & Diseases, Primary Immune Deficiencies (PIDs) are the main focus. This is an exciting and a rapidly emerging field of basic and clinical immunology wherein upwards of 400 clinical conditions, with approximately 350 defined mutations, are now recognized. Contrary to common perception, PIDs as a group are not uncommon. Epidemiologic studies show that population prevalence of PIDs is approximately 1:2000. Statistical extrapolations of this figure would suggest that in a large country like China or India, approximately 1 million individuals would be expected to have a PID. However, at present because of lack of awareness of these conditions amongst both the laity as well as medical professionals, majority of these patients remain undiagnosed and untreated in many developing countries. This is clearly unfortunate. PIDs can affect children as well as adults. While serious forms of combined immunodeficiencies are medical emergencies and usually present in early infancy, no age seems to be exempt from these disorders. The term Common Variable Immunodeficiency (CVID) refers to a heterogenous group of disorders that usually affect older children and adults. As its name suggests, the clinical and laboratory phenotype of CVID is variable. Because of this heterogeneity in clinical presentation, patients with CVID may, at times, remain undiagnosed for prolonged periods especially in regions wherein awareness about PIDs is not high. In this issue, Jindal et al 1 present an overview of current status of PIDs in Asia and show that while countries such as Japan, Taiwan and Korea have advanced laboratory and treatment facilities for PIDs that are comparable to the best in the world, there are several other regions in Asia that need to improve their infrastructure. This is followed by a succinct review on the newly recognized clinical entity, phenocopies of PIDs, by Jindal et al 2 and an update on genetics of CVID by Aggarwal et al. 3 The field of PIDs is advancing so rapidly that the gap between bench and bedside is narrowing down every year. Gene therapy and gene editing for PIDs, hitherto considered experimental therapy, is now a well-recognized clinical option for patients with disorders such as Severe Combined Immunodeficiency (SCID), Wiskott-Aldrich syndrome and Chronic Granulomatous Disease (CGD). Zhang et al 4 discuss these exciting therapeutic options that have recently become available. SCID is a syndrome that can have heterogenous clinical phenotypes and several genotypes. Pandiarajan et al 5 provide an updated overview of genetics of SCID and detail how the clinician can go about diagnosing these children. Kawasaki disease (KD) is a common pediatric vasculitis whose etiopathogenesis is still not clearly understood. Both innate and acquired immune mechanisms are believed to play a role in pathogenesis of this enigmatic condition. Jindal et al 6 discuss the emerging role of platelets in development of the cytokine cascade that is so very characteristic of KD. Several new phenotypes of PIDs have been identified in the last few years. Activated PI3 Kinase Delta Syndrome (APKDS) is one such disorder – Rawat et al 7 explain the clinical and laboratory profile of this fascinating condition. Hereditary angioedema is an uncommon immunological disorder but the acute exacerbations can be fatal if there are delays in diagnosis and treatment. Jindal et al 8 discuss the genetics and pathogenesis of this disorder and show how a clear understanding of the underlying defect goes a long way in developing appropriate therapeutic interventions. CGD is a phagocytic defect involving the innate immune system and can have both X-linked recessive and autosomal recessive forms of inheritance. Pandiarajan et al 9 discuss some of the recent advances in diagnosis and management of this condition. It is not often realized that early onset inflammatory bowel disease (IBD) can sometimes be the manifestation of an underlying PID. Suri et al 10 provide an update on the genetic basis of IBD and show how it is of paramount importance to consider this differential diagnosis while managing infants with severe forms of IBD. Leucocyte adhesion deficiency (LAD) is an uncommon defect of the innate immune system. It can have protean clinical manifestations and requires a high index of suspicion for early diagnosis. Sharma et al 11 discuss some of the diagnostic and therapeutic challenges of managing children with LAD. Hematopoietic stem cell transplantation is curative in LAD and gene therapy is rapidly emerging as an alternative therapeutic option in situations wherein HSCT is not suitable. Selective IgA deficiency is a complex PID and several patients may go on to develop CVID later in life. Some patients with IgA deficiency may also have associated IgG subclass deficiency. Song et al 12 provide a clinical review based on their experience of 16 patients with selective IgA deficiency in China. Basic and clinical immunology are closely related specialties. Our understanding of pathogenesis of newly emerging PID syndromes is dependent upon figuring out the underlying immunological mechanisms. This compendium of articles also has overviews of basic immunology covering RIPK1 deficiency 13 , atypical SIFD and multiple immune defects 14 , tissue engineering 15 and transcriptomic changes associated with PCK1 overexpression in hepatocellular carcinoma 16 . This issue of Genes & Diseases highlights some of the recent advances in field of clinical and basic immunology and also details the complexities of underlying genetic aberrations.

Supplemental Digital Content is available in the text, Introduction: S-1, a new oral fluorouracil chemotherapeutical drug, has been increasingly used in clinical maintenance after first-line chemotherapy for stage III or IV gastric carcinoma (GC) and colorectal carcinoma (CRC) for its own advantages. XiangshaLiujunzi Decoction (XSLJZD), a classic traditional Chinese medicine (TCM) formula with effects of alleviating the adverse reactions of chemotherapy and improving the quality of life of cancer patients has been gradually confirmed, with no more reports about the maintenance therapy mode of combination of chemotherapeutic drugs and TCM. We designed the study of XSLJZD combined with S-1 in the maintenance therapy of Stage III or IV GC and CRC, and hoped that this research program will go further and comprehensively evaluate its efficacy and safety. Objectives: The aim of this study was to determine the efficacy and safety of XSLJZD combined with S-1 in the maintenance therapy of stage III or IV GC and CRC. Methods: This study is an open, single-center, randomized study. Patients with stage III or stage IV GC and CRC will be randomized (1:1) into S-1group, S-1 combined with XSLJZD group for 5 years of maintenance therapy. The primary endpoint was progression-free survival, and secondary end point was overall survival and Quality of Life Assessment (QOLA), which include an improvement in symptoms before and after treatment, Karnofsky Performance Status, and adverse events assessment. Discussion: This study will provide meaningful clinical information about the combination of chemotherapeutic drugs S-1 with TCM in the maintenance therapy of stage III or IV GC and CRC. Trial registration: Chinese Clinical Trial Registry: ChiCTR-INR-16008575.

Background The prevalence of hypertension is high and is increasing worldwide, whereas the proportion of controlled hypertension is low. Purpose To assess the comparative effectiveness of 8 implementation strategies for blood pressure (BP) control in adults with hypertension. Data Sources Systematic searches of MEDLINE and Embase from inception to September 2017 with no language restrictions, supplemented with manual reference searches. Study Selection Randomized controlled trials lasting at least 6 months comparing the effect of implementation strategies versus usual care on BP reduction in adults with hypertension. Data Extraction Two investigators independently extracted data and assessed study quality. Data Synthesis A total of 121 comparisons from 100 articles with 55 920 hypertensive patients were included. Multilevel, multicomponent strategies were most effective for systolic BP reduction, including team-based care with medication titration by a nonphysician (-7.1 mm Hg [95% CI, -8.9 to -5.2 mm Hg]), team-based care with medication titration by a physician (-6.2 mm Hg [CI, -8.1 to -4.2 mm Hg]), and multilevel strategies without team-based care (-5.0 mm Hg [CI, -8.0 to -2.0 mm Hg]). Patient-level strategies resulted in systolic BP changes of -3.9 mm Hg (CI, -5.4 to -2.3 mm Hg) for health coaching and -2.7 mm Hg (CI, -3.6 to -1.7 mm Hg) for home BP monitoring. Similar trends were seen for diastolic BP reduction. Limitation Sparse data from low- and middle-income countries; few trials of some implementation strategies, such as provider training; and possible publication bias. Conclusion Multilevel, multicomponent strategies, followed by patient-level strategies, are most effective for BP control in patients with hypertension and should be used to improve hypertension control. Primary Funding Source National Institutes of Health.

Mesenchymal stromal cells (MSCs) have therapeutic potential for the prevention and treatment of graft-versus-host disease (GVHD). However, MSCs comprise several subpopulations, which have not been individually assessed for their role in GVHD suppression. In this study, we assessed the immunosuppressive effect of bone-related Sca1(+) MSCs on acute GVHD in a MHC-mismatched mouse model of allogeneic hematopoietic stem cell transplantation (HCT). Our results showed that Sca1(+) MSCs decreased the severity of acute GVHD (aGVHD) and prolonged the survival period of allogeneic HCT recipients. This effect was exerted through lowered T lymphocyte infiltration in target organs and by inhibition of CD80/86 expression on host dendritic cells. Furthermore, the expression of cytotoxic T-lymphocyte antigen-4 (CTLA-4), a negative regulator of T cells, was elevated in the recipient splenocytes. In conclusion, bone-related Sca1(+) MSCs subpopulation suppressed GVHD and could be a novel treatment for acute GVHD.

Radiotherapy is a vital treatment option for patients with nasopharyngeal carcinoma (NPC). Concurrent cisplatin-based radiochemotherapy with or without adjuvant chemotherapy had acquired good clinical effects with good local control rates. However, a number of patients present with metastasis following systemic regimens or initial diagnosis of locally advanced NPC, which cause difficulty for subsequent therapy. Therefore, there is an urgent requirement to discover novel targeted therapies. The present report describes one case of a patient with NPC and multiple metastases. The patient was treated with systemic therapy in combination with bevacizumab, palliative radiotherapy and chemotherapy following treatment with cetuximab and concurrent chemoradiotherapy in 2015. Following the addition of bevacizumab, metastases were reduced or disappeared after >2 months, and the duration of progression-free survival was 7 months. Bevacizumab is a monoclonal antibody that targets VEGF, and it is associated with angiogenesis, which causes the growth, invasion and progression of tumors. In previous studies, bevacizumab has been approved for the treatment of several types of malignant cancer and it has been able to effectively improve prognosis. In the present review, the effect of adding bevacizumab to systemic therapy for the treatment of NPC was analyzed, with a particular focus on advanced and metastatic diseases. A growing number of phase I/II clinical trials involving bevacizumab for NPC have been conducted with clinical outcomes showing improved rates of overall survival and progression-free survival as well as improvements in the quality of life of patients. However, severe or deadly toxicities can also result from combination treatment with bevacizumab. In the future, bevacizumab may become a common addition to systemic therapy for the treatment of locally advanced and metastatic NPC.

Background: The objective of this study was to explore the influence factors of hospitalization costs of treating colorectal cancer in China. And the study provides new estimates on hospitalization costs and length of hospital stay for patients with colorectal cancer in China. Methods: Data for inpatient hospitalization associated with colorectal cancer were obtained from a 3-tier hospital in Guangdong Province and were analyzed post hoc. We conducted descriptive statistical methods, Wilcoxon rank–sum tests (for 2 groups) and the Kruskal–Wallis test (for more than 2 groups) to analyze the hospitalization costs of treating colorectal cancer. Results: The analysis included 8021 patients (female: 40.54%; mean age; 61.80 ± 13.28 years; male: 59.46%; mean age: 61.80 ± 13.28 years). The overall mean length of hospital stay was 11.35 days. Over the 5 years, the mean length of hospital stay showed a small decrease from 12.22 days in 2012 to 10.69 days in 2016, while per-day costs showed a trend of increase between 2012 and 2015 (increase from

Er3+ and Yb3+ co-doped TiO2−xFx up-conversion luminescence powder (UC-TiO2−xFx) was fabricated via hydrothermal method and calcined at 500 °C for 2 h. The prepared powders were characterized by SEM, XRD, PL, UC-PL, UV–Vis, SPS and IPCE spectra. The results showed that UC-TiO2−xFx possessed the property of up-conversion, increasing the percentage of visible light that can be absorbed by N719 dyes; it got a lower band gap energy which contributed to a faster electrons injection and decreased the radiative recombination process of photo-generated electrons and holes in TiO2; and adequate F-doping could enhance the performance of luminescence and widened the light absorption in visible light range, but excessive F-doping could cause blue-shift. We applied the UC-TiO2−xFx into dye sensitized solar cell (DSSC), as a light scattering layer for its special morphology, to gain a higher light harvesting and a lower light loss so as to achieve a satisfied DSSC efficiency. Under the simulated solar irradiation of 100 mW cm−2 (AM1.5G), a short-circuit current density of 16.3 mA cm−2, an open-circuit voltage of 0.725 V and an overall energy conversion efficiency of 7.08% were obtained by introducing this light scattering layer.

11β-Hydroxylase deficiency (11β-OHD), caused by CYP11B1 mutations, is characterized by hyporeninemic, hypokalemic hypertension and hyperandrogenism. We identified a prevalent and three novel mutations of CYP11B1 gene in nine patients with classic 11β-OHD. Subjects and methods Nine patients with 11β-OHD from unrelated families were recruited. The complications of 11β-OHD occurred in three patients who never received glucocorticoid treatment. CYP11B1 gene was sequenced and 11β-hydroxylase enzymatic activities were assessed in vitro. A haplotype analysis was performed to determine a common ancestor for those subjects who carried the same p.R454C mutation. Results CYP11B1 gene mutations were identified in all patients, with a prevalent (p.R454C) and three novel mutations (p.V148G, IVS7-9C>A, c.1359_1360insG). The p.R141X, p.V148G, c.1359_1360insG and p.R454C mutations retained 4.9%, 3.9%, 3.7%, 4.5% of residual enzymatic activity, respectively. Five of nine patients carried p.R454C mutation, which was only reported in Chinese 11OHD patients. Haplotype analysis showed that this mutation might be inherited from a common ancestor. Conclusion The enzymatic activities for p.R141X, p.V148G, c.1359_1360insG and p.R454C mutants were almost completely abolished, which corresponds to classic form of 11β-OHD. The observations of a prevalent mutation and three novel mutations might have potential clinical utility for genetic counseling and prenatal diagnosis in Chinese 11β-OHD patients.

// Xi Lan 1 , Li-Juan Fu 1, 2 , Jun Zhang 3 , Xue-Qing Liu 1 , Hui-Jie Zhang 4 , Xue Zhang 1 , Ming-Fu Ma 5 , Xue-Mei Chen 1 , Jun-Lin He 1 , Lian-Bing Li 5 , Ying-Xiong Wang 1 and Yu-Bin Ding 1 1 Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing, 400016, P.R. China 2 Department of Immunology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, 15260, USA 3 Center of Molecular Diagnostic Medicine, Life Science Institute, Chongqing Medical University, Chongqing, 400016, P.R. China 4 Ministry of Education Key Laboratory of Diagnostic Medicine, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, P.R. China 5 The Key Laboratory of Birth Defects and Reproductive Health of the National Health and Family Planning Commission, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, 401147, P.R. China Correspondence to: Yu-Bin Ding, email: 178384198@qq.com Keywords: bisphenol A, extravillous trophoblasts, cell migration, placentation, MAPK/PI3K signaling pathway Received: September 28, 2016 Accepted: April 19, 2017 Published: May 16, 2017 ABSTRACT In this study, we investigated the effect of Bisphenol A (BPA), an endocrine-disrupting chemical, on the migration of human trophoblasts and mouse placentation by using the primary extravillous trophoblast (EVT) and its cell line HTR-8/SVneo, villous explant cultures, and pregnant mice. BPA increased EVT motility and the outgrowth of villous explants in a dose-dependent manner. BPA also increased the protein levels of integrin-β1 and matrix metalloproteinase (MMP)-9 in human EVTs. Low-dose BPA (≤50 mg) increased the protein levels of MMP-9 and MMP-2 as well as integrin-β1 and integrin-α5 in mouse placenta and decreased the proportion of the labyrinth and spongiotrophoblast layers. Inhibitors of mitogen-activated protein kinase (MAPK) U0126 and phosphatidylinositol-3-kinases (PI3K) LY294002 reversed the protein levels of integrin-β1 and MMP-9 as well as the migratory ability induced by BPA. In conclusion, these results indicated that BPA can enhance trophoblast migration and impair placentation in mice by a mechanism involving upregulation of integrin(s) and MMP(s) as well as the stimulation of MAPK and PI3K/Akt (protein kinase B) signaling pathways.

Nowadays, the idea of recognition based on image sets looms so large in real world applications. From the view of manifold learning, each image set has commonly been regarded as a manifold, and we formulate the problem of set recognition as manifold recognition (MR). Since it is impossible to directly compute the distance between nonlinear manifolds, constructing local linear subspaces is brought into our focus. Among methods offering of subspace matching, canonical correlations have recently drawn intensive attention. For the task of MR, we propose a method of Manifold Recognition Based On Discriminative-analysis of Canonical Correlations (MRDCC). The proposed method is evaluated on two datasets: Honda/UCSD face video database and ETH-80 object database. Comprehensive comparisons and results demonstrate the effectiveness of our method.

Chronic myeloid leukemia (CML) is a myeloid proliferative disorder mainly result from chimeric protein BCR-ABL1 encoded by a fusion gene at the t(9;22) (q34;q11) chromosomal translocation. Intrinsically, this recombined protein results in an increased tyrosine kinase (TK) activity that directly related to hematopoietic stem cell malignant proliferation. Consequently, the drugs derived from tyrosine kinase inhibitors (TKI) have been developed as an infective therapy, and greatly improved patients survival in clinic. Unfortunately, single TKI administration led to toxicities or tolerance in long-term treated CML patients. Even worse is, about 5% CML patients were not caused by bcr-abl gene mutation. Thus better medicines are badly needed to compensate CML therapy. Herein, we investigated the undefined function of a biscoumarins. The new synthesized compound exhibited a null toxicity on HUVECs but intensive toxicity on K562 leukemic cells. Subsequent results demonstrated that it efficiently inhibited the expansion of human CML cell line and bone marrow cells of SCL-tTA-BCL/ABL transgenic model mice via increased apoptosis. Critically, we also showed that CD34+ bone marrow leukemic cells collected from patients underwent more apoptosis after treated by the biscoumarins derivate. To extend these results into vivo, we observed a prolonged survival of bcr-abl transgenic mice treated by derivate mono-therapy or combination with imatinib compared to those of untreated or imatinib-treated CML mice. All together, these results indicated that this biscoumarins derivate may have novel potential as a therapeutic agent against CML. Disclosures No relevant conflicts of interest to declare.

The complete funding information is: "This work was supported by a grant from the the National Natural Science Foundation of China (30972147), the Ministry of Education of the People's Republic of China Program for Changjiang Scholars and Innovative Research Team in University (No. IRT0750), CSIRO and the Doctoral Innovation Fund of Southwest University (kb2008002). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."

In this paper, dynamic buckling of a martensitic transformation dominated super-elastic TiNi thin cylindrical shell under single loading was studied and analyzed. The results showed that the buckling mode was mainly the non-axisymmetric diamond model, and recovered when unloading, and related with martensitic transformation and the behavior of the transformation hinge, and was significantly different from the traditional elastic-plastic cylindrical shell. The article also discussed that the influence of the length-to-diameter rate and boundary conditions on buckling mode, specific energy, critical instability threshold, and so on. The study showed, as length and boundary conditions changed, TiNi thin cylindrical shells showed a variety of buckling modal development. Under the same boundary condition, S e was reduced as length-diameter ratio increased, had the similar law with the quasi-static compression experiments. But the specific energy of a TiNi thin cylindrical shell was greater than that in the quasi-static compression experiments.

Primary pulmonary paraganglioma is a rare disease. We report a case of a 37-year old female patient with space-occupying lesions in the right lower pulmonary lobe during a routine examination without any symptoms. The patient underwent video-assisted thoracoscopic surgery (VATS) resection of the right middle lobe and dissection of hilar and mediastinal lymph nodes under general anesthesia. She recovered without recrudescence. Preoperative diagnosis is difficult. Accurate diagnosis requires pathological examination, and immunohistochemical test is particularly important. Complete resection is the first treatment option for solitary primary pulmonary paraganglioma; however, VATS is a better technique. Given the high local control rates and few complications of radiotherapy, it is considered as a standard treatment.