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A dual-band miniaturized linear-to-circular metasurface polarization converter (LCPC) with wideband and wide-angle axial ratio is proposed and demonstrated. The metasurface is formed with periodic arrays of unit cells. The unit cells consist of three metallic layers separated by two substrates. The top and bottom metallic layers contain the identical cells with two metal strips and an “I”-type strip with four stubs for y-polarization each. The middle metallic layer comprises an infinitely long metal strip and two “I”-type strips for x-polarization. The LCPC performs a wideband response in both operating bands with the wide passbands generated by the orthogonal “I”-type strips. Prototyped K-/Ka-band design shows that the simulated/measured axial ratio (AR) remains below 3 dB over the lower bandwidth of 15-21.2 GHz (34.3%)/16.3-21.1 GHz (25.7%) and higher bandwidth of 27-30.3 GHz (11.5%)/27-29.8 GHz (9.9%) under normal incidence in y-z plane, respectively. For a 45°-incidence, the measured AR still achieved the 3-dB bandwidth of 33.7%/9.4% in both bands. The study shows that by virtue of orthogonal structures placed at different layers, the element size and the cross-polarization level are suppressed by 65% and 10 dB respectively, compared to the previous work. Furthermore, the LCPC with the miniaturized elements shows wide-angle response in both the bands.

Excessive glutamate leading to excitotoxicity worsens brain damage after SAH and contributes to long-term neurological deficits. The drug ifenprodil is a non-competitive antagonist of GluN1-GluN2B N-methyl-d-aspartate (NMDA) receptor, which mediates excitotoxic damage in vitro and in vivo. Here, we show that cerebrospinal fluid (CSF) glutamate level within 48 h was significantly elevated in aSAH patients who later developed poor outcome. In rat SAH model, ifenprodil can improve long-term sensorimotor and spatial learning deficits. Ifenprodil attenuates experimental SAH-induced neuronal death of basal cortex and hippocampal CA1 area, cellular and mitochondrial Ca2+ overload of basal cortex, blood-brain barrier (BBB) damage, and cerebral edema of early brain injury. Using in vitro models, ifenprodil declines the high-concentration glutamate-mediated intracellular Ca2+ increase and cell apoptosis in primary cortical neurons, reduces the high-concentration glutamate-elevated endothelial permeability in human brain microvascular endothelial cell (HBMEC). Altogether, our results suggest ifenprodil improves long-term neurologic deficits through antagonizing glutamate-induced excitotoxicity.

A wideband and wide-angle frequency selective surface (FSS) is proposed in this communication. The periodic element consists of a quarter-mode substrate integrated waveguide (QMSIW) cavity surrounded by two identical loop slots located on the top and bottom layers of the cavity. Two transmission poles and one transmission zero are caused by the fundamental mode in the QMSIW cavity, the slot mode, and the coupling between them, respectively. By precisely tuning the dual-mode configuration, the proposed FSS shows a wide passband with a good transmission efficiency and a rapid roll-off at the high side of the operation band due to the transmission zero. With the QMSIW-based miniaturized elements, the FSS is also insensitive to a large angle of incidence. Thanks to the novel structure, several higher order modes close to the target band are suppressed, making the parasitic passband far away from both sides of the designed band. To verify the advantages, a prototype operated at 10 GHz is fabricated and tested. The measured results show a wide passband performance with the 1/3 dB relative bandwidths of 34%/49% for normal incidence, which agree well with the simulated results. Besides, the 3 dB bandwidth still remains 23% for the incident angle of 60°.

Aneurysmal subarachnoid hemorrhage (SAH) causes permanent neurological sequelae, but the underlying mechanism needs to be further clarified. Here, we show that inhibition of metabotropic glutamate receptor 1 (mGluR1) with negative allosteric modulator JNJ16259685 improves long-term neurobehavioral outcomes in an endovascular perforation model of SAH. JNJ16259685 improves cerebrovascular dysfunction through attenuation of cerebral blood flow (CBF) reduction, cerebral vasoconstrictio, and microthrombosis formation in a rat SAH model. Moreover, JNJ16259685 reduces experimental SAH-induced long-term neuronal damage through alleviation of neuronal death and degeneration. Mechanically, JNJ16259685 maintains phosphorylation of endothelial NO synthase (eNOS) and vasodilator-stimulated phosphoprotein (VASP) and decreases apoptosis-related factors Bax, active caspase-9, and active caspase-3 following experimental SAH. Altogether, our results suggest JNJ16259685 improves long-term functional impairment through neurovascular protection.

Delayed cerebral ischemia (DCI) is an important complication after aneurysmal subarachnoid hemorrhage (aSAH). Early identification of cerebrospinal fluid (CSF) markers is helpful for warning of impending DCI. This study assessed whether early high CSF glutamate levels can be observed in aSAH patients who later developed DCI. In this prospective clinical study, patients with normal pressure hydrocephalus or aSAH were enrolled. We found that the early CSF levels of glutamate were significantly elevated in aSAH patients compared to patients with normal pressure hydrocephalus. There was a significant difference in early CSF levels of glutamate between aSAH patients without DCI and with DCI. The early CSF levels of glutamate are significantly related to the Hunt and Hess grade, the World Federation of Neurological Surgeons (WFNS) grade, and the modified Fisher score on admission and occurrence of DCI in aSAH patients. Preliminary evidence of this study suggests that early high CSF glutamate levels are correlated with DCI in aSAH patients.

A wideband and wide-angle linear-to-circular polarization converter (LCPC) based on a single-layer dielectric substrate is proposed. The converter element consists of a metal strip cross backed by a strip horizontally and centrically located on the other metallic layer. The vertical arm of the strip across the whole surface performs as a high- pass filter with a wide passband above a low cutoff frequency. Meanwhile, the horizontal strip resonates at a high out-of-band frequency and also offers a wideband response below the resonant frequency. Another two short strips vertically and horizontally placed around the crosses increase the phase shift caused by the crosses and improve both the passbands. Using equivalent circuit models and ANSOFT HFSS, an example of LCPC is designed with the overall element size of only $0.11\lambda _{0}\times 0.21\lambda _{0}$ for a 90° phase difference and wide-angle stability over the wide operation band. The prototype shows the simulated / measured axial ratios (ARs) below 3 dB over the bandwidth of 69%/74% for a normal incidence wave and 54% for the oblique incident angle of 55° in yz plane, respectively. With the insertion loss of less than 3 and 2 dB, the measured 3 dB AR bandwidth keeps 70% and 55%, respectively.

In order to improve the environmental monitoring and operation and maintenance level of the power distribution room, this paper designs an intelligent waterlogging sensor system, and introduces the overall design, hardware design, and software design of the sensor in detail. The sensor monitors the flooding situation based on the principle of liquid conduction, uses a ZigBee-based wireless transmission module and a 485 wired network to realize data transmission and communication between the sensor and the monitoring center, and judges the operation status of the power distribution room through the host computer. The low power consumption, long lifetime, and integration of waterlogging sensors are realized, which can improve resource utilization, reduce equipment installation costs, and provide technical reference for optimizing equipment operation.

Background Pancreatic adenoma can potentially transform into adenocarcinoma, so it is recommended to be resected surgically or endoscopically. Endoscopic papillectomy is one of the main treatments for papillary adenoma, and bleeding, perforation, and pancreatitis are the most frequent and critical adverse events that restrict its wider use. There is no standard procedure for endoscopic papillectomy yet. The procedure is relevant to postoperative adverse events. Aim To reduce the postoperative adverse event rates and improve patients' postoperative condition, we developed a standard novel procedure for endoscopic papillectomy. Methods The novel endoscopic papillectomy had two main modifications based on the conventional method: The isolation of bile from pancreatic juice with a bile duct stent and wound surface protection with metal clips and fibrin glue. We performed a single-center retrospective comparison study on the novel and conventional methods to examine the feasibility of the novel method for reducing postoperative adverse events. Results A total of 76 patients, of whom 23 underwent the novel procedure and 53 underwent the conventional procedure, were retrospectively evaluated in this study. The postoperative bleeding and pancreatitis rates of the novel method were significantly lower than those of the conventional method (0 vs 20.75%, P = 0.028, and 17.4% vs 41.5%, P = 0.042, respectively). After applying the novel method, the most critical adverse event, perforation, was entirely prevented, compared to a prevalence of 5.66% with the conventional method. Several postoperative symptoms, including fever, rapid pulse, and decrease in hemoglobin level, were significantly less frequent in the novel group (P = 0.042, 0.049, and 0.014, respectively). Overall, the total adverse event rate of the novel method was lower (0 vs 24.5%, P = 0.007) than that of the conventional method. Conclusion Patients who underwent the novel procedure had lower postoperative adverse event rates. This study demonstrates the potential efficacy and safety of the novel endoscopic papillectomy in reducing postoperative adverse events.

Key Clinical Message This article mainly reports the process of clinical diagnosis and treatment of a misdiagnosed Listeria monocytogenes meningoencephalitis. The patient's condition is aggravated because of the ineffective prophase therapy. In the later stage, we were mainly through combined antibiotics and given proper routes of administration, so that patient can recover quickly.

By applying moxibustion to the eight confluent points in different periods of time, to observe the changes in thermal pain threshold latency of acupoints based on Fei Teng Ba Fa. A total of 468 healthy college student volunteers received moxibustion at the eight confluent points in three different periods of time, i.e. Chen (7:00-9:00), Wu (11:00-13:00) and Xu (19:00-21:00). The thermal pain threshold latency was adopted to measure the changes in pain threshold of the eight confluent points under different conditions (different periods of time, different genders, different acupoints and different states of the acupoints) based on Fei Teng Ba Fa. Finally, thirty subjects dropped out and 438 subjects were included. The comparison of thermal pain threshold latencies of the eight confluent points in the same opening or closing state based on Fei Teng Ba Fa: latencies of the closing points and adjunct points were significantly different in different periods of time (P 0.05); in the female group, there was a significant difference in the latency between the lower-limb points and the upper-limb points (P

A frequency selective surface (FSS) based on hexagon substrate integrated waveguide (HSIW) technology is proposed in this letter and designed at the center frequency of 140 GHz. The periodic element comprises a HSIW cavity and two circular slots etched on the top and bottom conductor claddings of the cavity. Based on the hexagon cavity, this type of FSS has a better polarization stability and a closer element arrangement compared with square cavity FSS and circular cavity FSS, respectively. Besides, circular slots are better than polygonal slots which have round corners at their corners when fabricated using normal printed circuit board process. Thus, the HSIW FSS can achieve a good and stable performance at terahertz band. The proposed structure is fabricated and the measured result has a good agreement with the simulated one.

The existing mobility strategy of the anchor node in wireless sensor network (WSN) has the shortcomings of too long moving path and low locating accuracy when the anchor node traverses the network voids area. A new mobility strategy of WSN anchor node is proposed based on an improved virtual forces model. The number of neighbor nodes and the distance between the neighbor nodes to the anchor nodes are introduced as their own dense weight attributes. The unknown nodes intensity is used as weights to improve the traditional virtual force model. Using the number of messages received by the unknown node as the parameters to calculate the virtual force from the unknown node to the anchor node. Then according to the virtual force, choose the direction and move the anchor nodes. Simulation experiments show that the algorithm can make the anchor nodes move according to the specific circumstances of unknown node distribution. It has a high locating accuracy and strong adaptability. It can successfully shorten the path of the anchor node movement. Moreover it can effectively avoid the anchor node to enter the network voids area and reduce the number of collinear virtual anchor nodes.

To discuss the acupoints selection pattern in acupuncture-moxibustion treatment of perimenopausal syndrome (PMS) from 2007 to 2016. Clinical literatures related to PMS treated with acupuncture-moxibustion published from 2007 to 2016 were collected from Chinese Biomedical Literature Database (CBM), Chongqing VIP Database (CQVIP), China National Knowledge Infrastructure (CNKI), and Wanfang Academic Journal Full-text Database (Wanfang). The retrieved data underwent descriptive analysis, cluster analysis and association pattern analysis to determine the acupoints selection principle in acupuncture-moxibustion treatment of PMS. The top five acupoints used in acupuncture-moxibustion treatment of PMS were Sanyinjiao (SP 6), Shenshu (BL 23), Guanyuan (CV 4), Baihui (GV 20), and Shenmen (HT 7). The leading 4 meridians were Bladder Meridian, Conception Vessel, Spleen Meridian, and Governor Vessel. The clustering analysis showed that the 5 core acupoint groups were: ① Sanyinjiao (SP 6); ② Shenshu (BL 23) and Guanyuan (CV 4); ③ Baihui (GV 20), Shenmen (HT 7), Zusanli (ST 36), Ganshu (BL 18) and Taichong (LR 3); ④ Taixi (KI 3), Pishu (BL 20), Xinshu (BL 15), Qihai (CV 6) and Neiguan (PC 6); ⑤ Sishencong (EX-HN 1), Zhongwan (CV 12), Hegu (LI 4), Yintang (GV 29), Fengchi (GB 20), Zhongji (CV 3) and Feishu (BL 13). The three most significant acupoints were Sanyinjiao (SP 6), Shenshu (BL 23) and Guanyuan (CV 4). Acupoint groups based on syndrome differentiation included: ① Hegu (LI 4), Zhongwan (CV 12) and Sishencong (EX-HN 1); ② Feishu (BL 13), Zhongji (CV 3), Fengchi (GB 20) and Yintang (GV 29); ③ Xinshu (BL 15), Pishu (BL 20), Qihai (CV 6), Neiguan (PC 6) and Taixi (KI 3); ④ Ganshu (BL 18), Zusanli (ST 36), Shenmen (HT 7), Taichong (LR 3) and Baihui (GV 20). The analysis of association pattern elaborated that Shenshu (BL 23) and Sanyinjiao (SP 6) won the highest support rate in the paired groups; Ganshu (BL 18), Shenshu (BL 23) and Sanyinjiao (SP 6) had the highest support rate among the acupoint groups. The data mining results of acupuncture-moxibustion treatment of PMS substantially conform to the general principle in traditional acupuncture-moxibustion theories, able to reflect the acupoints selection and grouping pattern and provide references for acupuncture-moxibustion treatment of PMS.

Broadband printed-circuit-board characterization using a multimode substrate-integrated-waveguide (SIW) resonator is proposed and investigated in this paper. The resonator sample is fed by two closed rectangular waveguides through two coupling slots positioned at two ends of the cavity. A series of TE $_{\mathrm {10}{k}}$ resonant modes with large mode index can be excited sequentially in the cavity. This design is able to perform an effective control of the frequency interval ( $\Delta f$ ) between two neighboring modes. Besides, $\Delta f$ approaches to be a constant with a large mode index $k$ . This feature is important to test dielectric materials at small and approximately uniform frequency intervals. The detailed design process is introduced to synthesize the dimensions of the resonator sample and the feeding structure for a given operation frequency band. As an example, the Taconic TLY-5 substrate is measured at $Ka$ -band firstly to validate the accuracy of this method. Two types of samples with different thicknesses are fabricated and tested to calibrate the conductor loss. After that, this SIW multimode measurement is employed to accurately test the same substrates over the whole $W$ -band with approximately uniform frequency intervals. This task cannot be implemented by conventional resonance methods based on microstrip lines because of the selection of resonant modes and the radiation leakage.

A dual circularly polarized (CP) waveguide array antenna is presented for Ka-band wireless communication. A novel triple-resonant cavity is proposed to implement mode conversion and impedance matching in the $2 \times 2$ -element subarray. A ridge waveguide polarizer is integrated to form the left-hand circular polarization (LHCP) and the right-hand circular polarization (RHCP). A flyover-shaped full-corporate feeding network is designed to accommodate the dual polarizations and keep the wideband characteristic for a large-scale array. Subarray spacing is used to optimize the port-to-port isolation and decrease the sidelobe level at some definite angles. Computer numerically controlled machining technology is applied to fabricating a $16 \times 16$ -element prototype. Measured results demonstrate a bandwidth of 16% from 27.6 to 32.4 GHz for the dual polarizations, in terms of good reflection coefficient and axial ratio. A maximum gain of 32.8 dBic is achieved at 28.8 GHz. A total efficiency over 60% is obtained throughout the above band for both LHCP and RHCP ports.

Cisplatin-based chemotherapy has been widely used in the perioperative period of cancer surgery, which exacerbates the risk of renal injury. In this study, we examined whether dexmedetomidine (DEX), a commonly used anesthetic adjuvant, shows a protective effect against cisplatin-induced acute kidney injury. Acute kidney injury in mice was induced by cisplatin. Mice were administered with DEX 25 μg/kg or atipamezole 250 μg/kg (once a day, for 3 days) after cisplatin treatment. The renal function and tubular damage score were evaluated at 72 h following cisplatin administration. Apoptotic tubular cells were detected by TUNEL assay. Caspase-3, p53, Bax, F4/80+ macrophages, CD3+ T cells, and NF-κB were examined by immunohistochemistry staining or Western blot. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein (MCP)-1 in kidney were measured using real-time polymerase chain reaction. DEX treatment preserved renal function and reduced tubular damage score of mice after cisplatin administration. Mice treated with DEX exhibited less apoptotic tubular cells in response to cisplatin insult, which was associated with decreased Bax and reduced activation of p53 and caspase-3. DEX suppressed the infiltration of macrophages and T cells into the kidneys following cisplatin treatment, which was involved in the inhibition of NF-κB activation and decreased expression of TNF-α, IL-1β, IL-6, and MCP-1. Furthermore, we showed that the renoprotective effect conferred by DEX may be related to α2 adrenoceptor-dependent pathway. We demonstrate that DEX protects the kidney against cisplatin-induced AKI by the regulation of apoptosis and inflammatory response.

Background Cysticercosis is an emerging and neglected tropical disease (NTD) that poses a serious public health concern worldwide. Disseminated cysticercosis (DCC) is an uncommon manifestation of cysticercosis, also found in China. Case presentation We report three cases of DCC in patients living in China, with different clinical and radiological presentations. All three patients had DCC with active ocular cysticercosis, including one patient with widespread DCC caused by direct ingestion of Taenia solium eggs. The intravitreal cysticercus cyst in this patient was completely extracted entirely by 23-gauge pars plana vitrectomy, and the cyst was oval in shape on the flat mount preparation. Conclusion The clinical presentation of DCC is highly sophisticated. The diagnosis depended on the typical radiological presentations, biopsy and flat mount preparations of the cyst.

In this paper, high-temperature solar-blind photodetectors were fabricated based on polycrystalline Ga2O3 (poly-Ga2O3) film which was prepared by annealing amorphous Ga2O3 (a-Ga2O3) film in oxygen atmosphere. The effects of annealing temperature on the properties of the material and the performances of the corresponding Metal–semiconductor–metal photodetector were investigated. The main factors affecting device performance are attributed to the oxygen vacancy defect concentration in Ga2O3 and the effective Schottky barrier height and width between gold and Ga2O3. We found that the detector based on 650 °C annealed poly-Ga2O3 showed the best solar-blind detection photoelectric performance and good thermal stability. More interestingly, the device has fast response recovery speed (0.16 s), low dark current (≤0.1 nA) and high photo-to-dark current ratio (≥97) at 200 °C high temperature operation. These performances are even better than the reported high-temperature photodetectors based on high-quality crystal Ga2O3 thin film or Ga2O3 bulk. Besides, our method that avoid direct high-temperature growth of poly-Ga2O3 and may be beneficial to its commercial large-area production and further cost reduction.

For nursing overactive bladder syndrome in the lower urinary tract, it is important to understand the origins of urination-desire sensing during natural bladder filling. This study proposes a noninvasive urination-desire sensing method based on bioimpedance (BI) spectrum analysis. For BI measurement of the bladder, two excitation electrodes and two measurement electrodes are placed on the hypogastric surface of the body. The measurement system for BI provided a 0.2-mA alternating current with a 50-kHz frequency, which was sufficient to continuously measure the changes of the bladder during the various control stages of bladder filling. The results show that the higher-frequency spectral power (0.15–0.4 Hz) decreased (p = 0.05) and the low-to-high frequency ratio significantly increased (p = 0.001) during natural bladder filling for 12 healthy male volunteers. In contrast, the change in the lower-frequency spectral power (0.04–0.15 Hz) was insignificant. So to some extent, the method can be used to check the necessity to void for bladder, and assess neural regulation during bladder filling.

A frequency selective surface (FSS) with miniaturized elements based on a quarter-mode substrate integrated waveguide (QMSIW) is proposed and investigated in this paper. The periodic element includes the QMSIW cavity and two L-type slots etched on the top and bottom conductor claddings of the cavity. The slot not only performs as the equivalent magnetic wall of the QMSIW FSS element but also provides a pole near the resonant frequency of the QMSIW cavity to improve the passband characteristics of the FSS. In this case, the size of the conventional FSS element can be reduced by 65% at the same operation frequency while keeping a similar performance. Based on this miniaturized element, the frequency interval between the passband and the first parasitic passband can increase 2.7 times compared with that of a conventional SIW FSS. As an example, an X-band QMSIW FSS is designed, fabricated, and measured. Besides, it is insensitive to the incident angle and polarization of the incident wave. Such a miniaturized FSS element can also be employed in the design of a multiband FSS with controllable transmission zeroes.

To eliminate the time-consuming oil-gas separation process in online dissolved gas detection of power transformer, fiber Bragg grating (FBG)-based hydrogen sensor is proposed to be installed into the power transformer oil directly. In the sensor design, the FBG cladding is side-polished with a residual thickness of 20 μm and sputtered with palladium/silver. Since side-polished cladding is very sensitive to curvature strain induced by palladium in the presence of dissolved hydrogen, the proposed sensor is much more sensitive than the untreated FBG hydrogen sensor. Measurements prove that the sensitivity is as high as 0.477 (pm/(μL/L)), about 11.4 times higher than the conventional FBG hydrogen sensor. Furthermore, repeatability and short-term stability have been investigated. The performances satisfy the actual need of monitoring dissolved hydrogen concentration in power transformer oil.

Most optical hydrogen sensors are based on light intensity measurement and light intensity detection is vulnerable to the light source output and the optical fiber arrangement. To overcome the shortcomings, an optical fiber based sensor based on fiber Bragg grating (FBG) technique which is capable to measure the concentration of hydrogen dissolved is described in this paper. To examine the availability of monitoring initial hydrogen generation, a needle-to-plate partial discharge (PD) model was setup in the lab. The results between wavelength shifts of optical hydrogen sensor well agreed with conventional dissolved gas analysis (DGA), proving a potential utilization in the detection of dissolved hydrogen in power transformer.

This paper presents the development and fabrication of fiber Bragg grating hydrogen sensor by using magnetron sputtering method to overcome the problem of hydrogen embrittlement.With compact, smooth and high quality thin films deposited by magnetron sputtering, two layers have been sputtered around the fiber cladding: titanium (Ti) layer (20nm) and palladium (Pd) layer (500nm). Between the two layers, Ti is acted as adhesive coatings to ensure connection between fiber and Pd film. Finally, the performance of the developed FBG hydrogen sensor was tested in the laboratory under low hydrogen concentration. The results prove that the fabricated hydrogen sensor has a high sensitivity of 22.67pm/%H2.

This paper mainly discusses the applications of real-time data mining technology in fault prediction of power plant generator. Massive real-time historical data of thermal power plant turbine generator equipment is stored to realize comprehensive quantitative assessment of thermal power plant turbine generator’s online security status and potential failure Early Warning. It is based on the Real-time data mining analysis and modeling techniques.

Depression caused by genetic and environmental factors is acomplicated disease. Here, it is demonstrated that glycogen synthase kinase-3β is highly expressed and phosphorylated in the brain of a chronic stress mouse. Inhibition of glycogen synthase kinase-3βleads to decreased depression-like symptoms which manifest in open-field test, tail-suspension test, forced swim test, and a novelty suppressed feeding test. It was also found that β-catenin is attenuated, and its target genes Cyclin D1 and c-Myc are down-regulated. Glycogen synthase kinase-3β was also found to inhibit Erk-Creb-BDNF signaling. These results show that glycogen synthase kinase-3β may promote the progression of depression. Therefore, targeting glycogen synthase kinase-3β may be an effective therapeutic strategy.

Fracture accidents of a certain type of pump shaft on a ship occurred repeatedly at runtime. The physicochemical properties, macro morphology, microstructure, chemical compositions at typical locations are analyzed in this paper. The main reason of the accidents is fatigue fracture. The material analysis and subsequent force-vibration analysis give the main cause of pump shaft fracture and provide guidance for ships design.

To observe the effect of reinforcing and reducing manipulation by breathing on yin and yang meridian points for motor function of knee joints in patients with ischemic stroke. A total of 60 ischemic stroke cases were randomly allocated into an observation group and a control group, 30 in each group. Other than basic and conventional rehabilitation therapies, cases in the observation group were treated with reinforcing and reducing manipulation on yin and yang meridians points for a period of 8 weeks; whereas cases in the control group only received the same basic and conventional rehabilitation therapy as that in the observation group. Then the knee joint energy, support moment and shaking moment were compared between the two groups before treatment, and after 4-week and 8-week treatment respectively. Before treatment, there were no between-group significant differences in knee joint energy, support moment and shaking moment (all P>0.05). After treatment, the knee joint energy, support moment and shaking moment in both groups were significantly improved (P

On the strength of the description of scalar diffraction theory, the difference between the sinusoidal grating and the black–white transmission grating in diffraction is caused by the transmittance of aperture. The diffraction experiment of sinusoidal grating in soft X-ray region is simulated by Matlab through the physical formulas is parsed. The conclusion attained in this simulation is that the distance of the 0th and 1st diffraction lines of sinusoidal grating is proportional to the wavelength of the incident light, transfer distance and the grating frequency, and is independent of the amplitude modulation, which affects peak intensity of the 1st diffraction. Additionally the main lobe width of the 1st diffraction is also influenced by the wavelength, transfer distance and grating effective acreage. This provides the theoretical basis for the property testing and the future widening of the application of the sinusoidal grating.

Response surface methodology based on single factors was used to optimize the process condition for extraction of nitrite nitrogen in sediment . The results indicated that the extraction amount of nitrite nitrogen was 9.5μg /g under the optimum condition of extraction time of 44min, ultrasonic power of 280W, solid-liquid ratio of 1:19,which was closed to the predicated yield of 9.3μg/g. The process can be used for the extraction of nitrite nitrogen in sediments.

Objective We observed the clinical effect of massage in treating chronic persistent pediatric asthma and the changes in expression of TLR1, TLR2, and TLR4 on macrophages. Methods One hundred sixty pediatric patients with persistent chronic asthma were collected, and divided into treatment and control groups of 80 each in strict accordance with the principle of random allocation. The patients in the control group received general nebulizer therapy, and the patients in the treatment group received infantile massage. Both groups of patients were observed for 3 months with respect to the following indicators: the frequency of asthmatic attacks; the frequency of respiratory tract infections (RTIs); C-ACT rating; and the PEF% of peripheral blood (PB) before and after treatment to detect macrophage TLR1, TLR2, and TLR4. Results After treatment, the frequency of asthmatic attacks, frequency of RTIs, C-ACT rating, and the PEF% and macrophage TLR1, TLR2, and TLR4 expression of fluorescence intensity in the treatment group showed a statistically significant increase when compared with the control group (*P Conclusion Pediatric massage can improve the clinical symptoms of pediatric asthma by up-regulating the expression of macrophage TLR1, TLR2, and TLR4.

In order to further enhance the performance of syntax parsing, for the shortcomings of hidden Markov model (HMM) in the parameter optimization, an improved syntax parsing method based on adaptive genetic annealing and HMM was presented. First, an adaptive hybrid genetic annealing algorithm was adopted to optimize HMM initial parameters. Second, the improved HMM was trained by Baum Welch algorithm, and then a modified Viterbi algorithm was used to recognize various types of phrases at the same layer, finally a hierarchical analysis algorithm and Viterbi algorithm were combined together to solve hierarchy and recursion in the sentence. In the adaptive genetic annealing HMM algorithm, genetic operators and parameters of simulated annealing (SA) were first respectively improved, subpopulations were classified according to the adaptive crossover and mutation probability of GA in order to realize the multi-group parallel search and information exchange, which could avoid premature and accelerate convergence, then SA was taken as a GA operator to strengthen the local search capability. Compared with several new approaches, Fβ = 1 value is averagely increased by 3%. The experiment results prove that this method is very effective for syntactic parsing.

By Using polymer modified asphalt bridge deck waterproof coating synchronous shearing spraying technology, the fiber reinforced bridge deck waterproofing adhesive layer had succeed carried out in Xisang highway bridge. Shear test was conducted in the waterproof layer structure. When completed bridge deck pavement, core was drilled and samples were carried out pull-out test. The results indicate that fiber reinforced bridge deck waterproof layer can improve waterproof coating gave resistance, crack resistance and tensile ability. The introduction of asphalt bridge deck waterproof can improve the bonding strength between the layers and the overall shear strength of the waterproof layer, enhance the overall waterproof effect and enhance the service life of asphalt layer effectively.

Electrode configuration is an important issue in the continuous measurement of respiration using impedance pneumography (IP). The robust configuration is usually confirmed by comparing the amplitude of the IP signals acquired with different electrode configurations, while the relative change in waveform and the effects of body posture and respiratory pattern are ignored. In this study, the IP signals and respiratory volume are simultaneously acquired from 8 healthy subjects in supine, left lying, right lying and prone postures, and the subjects are asked to perform four respiratory patterns including free breathing, thoracic breathing, abdominal breathing and apnea. The IP signals are acquired with four different chest electrode configurations, and the volume are measured using pneumotachograph (PNT). Differences in correlation and absolute deviation between the IP-derived and PNT-derived respiratory volume are assessed. The influences of noise, respiratory pattern and body posture on the IP signals of different configurations have significant difference (p < 0.05). The robust electrode configuration is found on the axillary midline, which is suitable for long term respiration monitoring.

This paper discussed the effect of Suizhong 36-1 oilfield reinjection sewage on core permeability in different suspending particle sizes, different concentration of suspended substances and different injection volume of water. The experimental results showed that: The larger the suspended particles diameter, the greater the concentration, the higher the injury rate; The lower the formation permeability, the greater the damage; The core permeability was markedly decreased with the increase of the volume of injected water; The formation damage degree was D11 > mixed injection > well water.

Ten mixed-breed female dogs were used in the study. Abdominal wall lifting was performed with a sterilised cotton strip. Four portal sites were used to complete gasless laparoscopic ovariohysterectomy (GLOHE) procedures. The proper and suspensor ligament, ovarian pedicle, and broad ligament of the uterus, uterine artery and vein were coagulated using bipolar electrocoagulation. After the uterine body was coagulated and cut, the end of the cervix was ligated with a loop suture. Blood samples were obtained before the surgery, immediately after the procedure, and on 1, 3, and 5 d postoperatively for the determination of interleukin-6 (IL-6) and C-reactive protein (CRP). No significant surgical complications occurred. After gasless laparoscopic ovariohysterectomy, a significantly higher serum IL-6 level was found immediately after the surgery and 1 d postoperatively when compared with the level observed after traditional laparoscopic ovariohysterectomy (LOHE). However, no significant differences were observed in CRP level between GLOHE and LOHE. GLOHE proved to be a safe and feasible procedure in bitches.

This study focused on anaesthesia and cardiopulmonary effects of tiletamine-zolazepam/xylazine/tramadol in miniature pigs and its effects on endothelium-derived vasoactive factors. A total of 14 eight-month-old Chinese experimental miniature pigs were used in this study. Tiletamine-zolazepam (3.5 mg·kg-1), xylazine (1.32 mg·kg-1) and tramadol (1.8 mg·kg-1) were administered i.m.; blood pressure and heart rate were recorded. At the same time, blood was collected through precaval vein, and nitric oxide, endothelin, 6-keto-PGF1α and thromboxanes B2 were determined by colorimetry and radioimmunoassay. The mean times to dorsal recumbency, duration of immobilization, standing and walking were 2.26 ± 0.72, 87.57 ± 9.61, 25.63 ± 12.55 and 36.70 ± 14.53 min, respectively. Blood pressure was significantly changed at 10 and 80 min (P < 0.01), and the heart rate ranged from 89 to 134 bpm without episodes of severe bradycardia or tachycardia. Significantly positive correlation was observed between endothelin, thromboxanes B2 and blood pressure as well as the heart rate (P < 0.05). There was negative correlation between PGI2 and blood pressure as well as heart rate (P < 0.05). The results showed that endothelin, 6-keto-PGF1α and thromboxanes B2 participated in the changing of cardiopulmonary parameters which were caused by tiletamine-zolazepam-xylazine-tramadol anaesthesia in miniature pigs, and the 6-keto-PGF1α, ET and TXB2 concentrations in plasma participated in the changing of blood pressures during anaesthesia. Therefore, we can recommend tiletamine-zolazepam/xylazine/tramadol for anaesthesia in pigs, and this study also contributes to the evaluation of the effect of endothelium-derived vasoactive factors during anaesthesia.

There are few researches on seismic response of reinforced concrete rib arch bridges at present; therefore, it is necessary to analyze seismic performance of this kind of bridges. Based on the engineering background of a three-span reinforced concrete rib arch bridge, a full bridge finite element model is built to analyze the structural dynamic characteristic and seismic response of the bridge. The internal forces and displacements of each key section is compared and discussed when the bridge is excited by horizontal unidirectional ground motion or the combination of vertical and horizontal ground motion. The structural seismic response calculated with different analysis methods is compared. The research results of this study can be used as a reference for the seismic design of similar bridges.

To evaluate the safety and effectiveness of Shenbei Guchang capsules in treatment of diarrhea type irritable bowel syndrome (yang deficiency of spleen and kidney) under widely used conditions, an open, multicenter, controlled, phase Ⅳ clinical trial was conducted in the drug clinical trial centers of 16 domestic hospitals. 2 123 patients from June 10, 2011 to November 29, 2012 were enrolled in the trial. Drug clinical trial was approved by Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital Ethics Committee before implementation. Before the start of trial, subjects were selected according to the research scheme and inclusion criteria, then they would step into the 14 d study after signing Informed Consent Form. All subjects were treated according to the research scheme, evaluated the conditions and filled in CFR sheet, to provide the evaluation data and information on safety and efficacy of Shenbei Guchang capsules. Shenbei Guchang capsules were used to treat diarrhea type irritable bowel syndrome in widely used conditions (2 123 cases), and 2 029 cases of them entered FAS set, cure+markedly effective in 1 921 cases, with a comprehensive curative effect rate of 94.68%; 2 010 cases of them entered PPS set, cure+markedly effective in 1 906 cases, with a comprehensive curative effect rate of 94.83%. The primary symptoms of IBS were abdominal pain and diarrhea. After treatment, both abdominal pain and diarrhea were improved, with significant differences (P

Traditional methane detection techniques in power transformer oil have the problems of cross sensitivity and insecurity factor. Based on Beer-Lambert spectral absorption law, low concentration methane detection with tunable diode laser absorption spectrum is proposed in this paper for the advantages of high sensitivity and resolution. Firstly, the central wavelength of 1653.72 nm in near infrared spectrum is selected. Then long optical length gas cell by means of refraction and reflection more than 20 times is built in the laboratory. At last, at different concentrations ranging from 50∼1000 μL/L, the harmonic signal waveforms are obtained. Experimental results show that the lower detection limit of this developed methane system can detect 1.28 μL/L approximately and the deviation is less than 0.02 V, which proved to be a prospective sensing technique to be utilized in power transformers.

The objective of this study was to investigate the suitability of tiletamine/zolazepam-xylazine-tramadol combination for miniature pigs. Fourteen Chinese experimental miniature pigs subjected to this study received 3.5 mg tiletamine/zolazepam kg−1 bw, 1.32 mg xylazine kg−1 bw and 1.8 mg tramadol kg−1 bw intramuscularly, as a mixture of the drugs. Cardiopulmonary, biochemical and haematological parameters were recorded before drug administration and after anaesthesia. The combination of the compounds resulted in anaesthesia lasting about 87 min and a satisfactory immobilization for handling. Cardiopulmonary parameters were changed after administration, but there were within biologically acceptable limits. Biochemical and haematological values decreased after drug administration, however, they returned to the baseline at 24 h. At the doses described, tiletamine/zolazepam-xylazine-tramadol combination produced good immobilization in miniature pigs with minimal changes over time in cardiopulmonary, biochemical and haematological parameters.

A new visual servo control scheme for a robotic manipulator is presented in this paper, where a back propagation (BP) neural network is used to make a direct transition from image feature to joint angles without requiring robot kinematics and camera calibration. To speed up the convergence and avoid local minimum of the neural network, this paper uses a genetic algorithm to find the optimal initial weights and thresholds and then uses the BP algorithm to train the neural network according to the data given. The proposed method can effectively combine the good global searching ability of genetic algorithms with the accurate local searching feature of BP neural network. The Simulink model for PUMA560 robot visual servo system based on the improved BP neural network is built with the Robotics Toolbox of Matlab. The simulation results indicate that the proposed method can accelerate convergence of the image errors and provide a simple and effective way of robot control.

Based on the method of CFD, a study on the structure parameters that affect the performance of chevron-type corrugated plate were carried out by simulating with the CFD software Fluent. The impact on flow and heat transfer performance were compared in different plate arrangement forms, different corrugation angles, corrugation depths and corrugation spacing for periodic boundary condition. The results show that heat transfer can be enhanced by staggering the plates. Heat transfer performance is about 1.444 times as corrugation angel is 60° to that of 30° while friction factor is 6.97 times as the angel is 70° to that of 30°. Comprehensive performance is higher at a small corrugation angel. When the ratio of corrugation length to depth is less than 3.0, skin friction factor increases with the increasing of depth, the dimple corrugated plate is about 59.2% and 58.7% higher than the common one on heat transfer and friction factor respectively.

On the basis of summary and analysis of the characteristics of concrete hollow blocks and composite masonry walls, this paper puts forward the concept of composite masonry wall with condensed core columns. Regarding the distance between core columns (s=600mm and s=1200mm) as the main influencing factors, two composite masonry walls were designed and built to carry out the axial compression capacity experimental study. The results of the study show that the composite masonry wall with condensed core columns can greatly improve the ultimate axial compression capacity of the wall, delay the fracture process, and influence the failure modes. In the entire experiment, the deformation of concrete hollow blocks and core columns was basically the same, and can work in coordination. The stress mechanism of the composite masonry wall which had splitting fracture changed from the composite masonry wall to the (weak) frame structure, which finally formed column hinge and got destroyed. The experimental results of this paper can provide a new way for the application of concrete hollow blocks as main wall materials in the field of high-rise buildings. The establishment of axial compression capacity formula and the eccentric compression performance of the composite masonry wall with condensed core columns deserve further study.

The paper first displays the feature of food, then points out the significance of putting into practice the Customer Relationship Management and supply chain administration in selling management, thereby draws out data mining. Finally, the paper describes the application of data mining in food.

Objective— To report laparoscopic splenectomy in goats. Study Design— Experimental study. Animals— Healthy female goats (n=9); aged, 10–18 months; weighing, 22–30 kg. Methods— Food was withheld for 24 hours and water for 10 hours. Anesthetized right laterally recumbent goats had a laparoscopic portal and 3 instrumental portals created in the left flank. Splenic attachments were dissected with monopolar electrocautery and blunt dissection through 2 instrument portals. Exposure and isolation of splenic vessels was performed with laparoscopic “right-angle” preparation forceps. Vessels were ligated with a medium-titanium clip and 2 silk sutures and then transected between the silk sutures. The detached spleen was manipulated into a specimen retrieval bag, morcellated, and the bag retrieved through an enlarged portal. Repeat laparoscopic examination was performed at 1 month. Results— Laparoscopic splenectomy required 70 minutes (range, 52–88 minutes) and was successful without major intraoperative and postoperative complications. Postoperatively, all goats had signs of mild abdominal discomfort. On repeat laparoscopy, with the exception of 1 goat that had a focal omental adhesion to the enlarged portal site, no other abnormalities were identified. Conclusions— Laparoscopic splenectomy can be accomplished in goats using 4 portals in the left flank and a combination of monopolar cautery dissection of splenic attachments, ligation of vessels using metal clips and intracorporeal ligatures, and intra-abdominal morcellation of the detached spleen in a specimen retrieval bag. Clinical Relevance— Laparoscopic splenectomy is an effective and safe technique in goats.