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Adaptive, 3-interval, 3-alternative forced-choice discrimination experiments were performed for changes in the amplitude of single elements that composed two-tone complexes. We utilized two-tone complexes of fixed frequency difference or fixed frequency ratio for each of several center frequencies. Experiments were carried out while roving overall stimulus intensity within and across trials. Sensitivity measured with two-tone complexes with a fixed frequency difference of 60 Hz reached a minimum of 0.5 dB for center frequencies near 1 kHz. In contrast, sensitivity measured with a fixed frequency ratio of 1.059 remained fairly invariant with changes of the center frequency. In general the results suggest that the auditory system performs an across-channel spectral profile analysis. Some of the results appear unexplainable by existing models, including the envelope-weighted averaged instantaneous frequency (EWAIF) model, which has explained many of such data in the past.

To the Editor:— In an article by Dr. Wilbur E. Post and myself on "The Comparative Efficiency of Some Common Germicides" which appeared inThe Journal, Nov. 5, 1910, the value of chinosol as a germicide was the subject of criticism. Since the publication of the article, my attention has been called to the fact that chinosol is no longer advertised as a germicide nor has it been since the Council on Pharmacy and Chemistry proved to the satisfaction of its manufacturer that, while it possessed antiseptic powers, its germicidal action was practically nil. Our criticisms of this preparation, therefore, were without foundation. Chinosol was examined by us because at the time our experiments were made this product was advertised and sold as a germicide. In publishing the results of our work reference to chinosol should, of course, have been omitted.

An extensive literature bears witness of the attempts which have been made in the past few years to make some use of passive immunization by means of antiserums against various forms of streptococcus infection. The serums prepared by Marmorek, Aronson, Moser and Menzer were perhaps given the most exhaustive trials. It appears that only a moderate and only a variable degree of success has been attained as compared with some of the effective immune serums, and it seems probable that some of the factors in the production or transfer of the immune bodies are at fault. The causes of this discrepancy have been sought in various parts of the immunizing process such as a lack of specificity in the organism used, the absence of polyvalence, insufficient dosage, and the apparently demonstrated fact that the streptococcus develops no true antitoxin, so that any immunity must be entirely phagocytic and would require

In the case of an obstinate gonorrheal arthritis in a hospital, the advisability of injecting argyrol into the joint arose and the question was asked, What is the germicidal power of this preparation? The literature seemed indefinite and various in its answers and tests were accordingly made. The results were so unexpected and so much at variance with the prevalent opinion that the tests were repeated and extended to protargol, and silver nitrate, and from these to a considerable number of germicides in ordinary use for clinical purposes in a large well-regulated hospital. As a consequence of the evidence produced, many solutions previously in use in that hospital have been discarded and in their place more effective ones substituted. Because of the daily interest of clinicians, as well as the importance of the subject to patients, a summary of these investigations is here presented. The development of methods for testing

To the Editor:— In the article March 26 by Dr. George B. Hassin there are references, both in the heading of the article and in the text, to nerve injuries caused by intravenous injections of dextrose. After reading the article I am at a loss to understand why dextrose was included as part of the cause of these injuries, since the case records seem to indicate quite clearly that the injuries were incident to the injections and not to the substance injected.