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2,135 results on '"Hermes A"'

1. Design of an early alert system for PM2.5 through a stochastic method and machine learning models

Author

Carlos Arturo Peña Rincón, Nathalia Celis, Hermes Martínez, Ellie Anne López-Barrera, Ricardo Arenas, Alejandro Casallas, and Camilo Ferro

Subjects
Computer science, business.industry, Geography, Planning and Development, Artificial intelligence, Management, Monitoring, Policy and Law, business, Machine learning, computer.software_genre, Alert system, computer
Published
2022
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2. Simulation of humidity fields in aerial lime mortar

Author

Anna Meneghini, Hermes Carvalho, Mateus Oliveira, and Erika Tinoco Guimarães

Subjects
Archeology, business.industry, Materials Science (miscellaneous), 0211 other engineering and technologies, Humidity, 02 engineering and technology, Conservation, engineering.material, Masonry, 021001 nanoscience & nanotechnology, Thermal diffusivity, Chemistry (miscellaneous), 021105 building & construction, engineering, Geotechnical engineering, Lime mortar, Mortar, 0210 nano-technology, Porosity, business, Porous medium, General Economics, Econometrics and Finance, Spectroscopy, Geology, Lime
Abstract

The structural safety of historic buildings frequently demands an advanced structural analysis. These constructions often have cultural and architectonic values and were constructed with porous materials bond with mortar. Mortar usually presents a complex composition and structural behavior. This fact supports the requirement for a meticulous analysis of the role of mortar within the scope of the structural behavior of historic masonry construction. In different parts of the world, there is a significant quantity of historic constructions comprehending binders based on aerial lime mortars. Aerial lime is one of the oldest binders discovered and used. Moisture content in aerial lime structures has an important influence on their behavior and performance. An experimental program was developed to study the humidity flux in aerial lime mortar including the self-desiccation phenomenon. In order to simulate this drying process, a software based on a Finite Difference Method Algorithm (1D and axisymmetric cases) is used. The pioneer software used to identify the main material parameters that better fit the experimental data, considering the approach presented by Model Code 2010. The modeling strategy was firstly applied to experimental results of cylinders specimens and in sequence to experimental results of a prismatic mold. In general, the model was able to satisfactory fit the experimental results. When compared to concrete material, higher values for diffusivity and for boundary coefficient were found. For the studied specimens, the experimental and numerical results indicated reduced humidity gradient. These results are probably associated with the high porosity of the mortar.

Published
2022
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3. Thrombin generation assays are versatile tools in blood coagulation analysis: A review of technical features, and applications from research to laboratory routine

Author

Stephan Schwers, Julia Mueller, Peter Turecek, Nikolaus B Binder, Matthias Germer, François Depasse, Björn Hermes, and Thomas Dr. Wissel

Subjects
medicine.drug_class, business.industry, Antithrombin, Anticoagulant, Thrombin, Hematology, Computational biology, Fibrinogen, Thrombin generation, Coagulation, Hemostasis, medicine, Coagulation testing, Humans, Blood Coagulation Tests, business, Blood Coagulation, Laboratories, Clinical, circulatory and respiratory physiology, medicine.drug
Abstract

Thrombin is the pivotal enzyme in the biochemistry of secondary hemostasis crucial to maintaining homeostasis of hemostasis. In contrast to routine coagulation tests (PT or aPTT) or procoagulant or anticoagulant factor assays (e.g. fibrinogen, factor VIII, antithrombin or protein C), the thrombin generation assay (TGA), also named thrombin generation test (TGT) is a so-called "global assay" that provides a picture of the hemostasis balance though a continuous and simultaneous measurement of thrombin formation and inhibition. First described in the early 1950s, as a manual assay, efforts have been made in order to standardize and automate the assay to offer researchers, clinical laboratories and the pharmaceutical industry a versatile tool covering a wide range of clinical and non-clinical applications. This review describes technical options offered to properly run TGA, including a review of preanalytical and analytical items, performance, interpretation, and applications in physiology research and pharmacy.

Published
2021
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4. Testing and modelling of hot-rolled steel castellated hollow tubular beams

Author

Hermes Carvalho, M. Anbarasu, Anjali Kumari Pravin Kumar Pandey, and M. Longshithung Patton

Subjects
Materials science, business.industry, Three point flexural test, Stiffness, Building and Construction, Structural engineering, Bending, Finite element method, Steel square, Structural load, Flexural strength, Deflection (engineering), Architecture, medicine, medicine.symptom, Safety, Risk, Reliability and Quality, business, Civil and Structural Engineering
Abstract

Researchers and design engineers are increasingly interested in castellated beams because of their ability to provide greater flexural strength with lower dead loads, as well as provide services and cost-effective structures. The influence of castellation on the bending strength and stiffness of the hot-rolled steel Square Tubular Beams (STBs) and Castellated Tubular Beams (CTBs) with simply supported end conditions were investigated in this study. Totally eight bending tests were carried out on hollow tubular beams with and without castellation under three point bending. The STBs with a nominal steel tube thickness of 2.5 mm are castellated in a hexagonal pattern. The ultimate moments, moment versus mid-span deflection response curves, and failure patterns are provided as part of the test results. The bending tests show that the flexural capacities and stiffness of the hollow tubular sections significantly increased due to the castellation process. Finite element (FE) models of STBs and CTBs were established by including the material and geometric nonlinearity as well as the measured geometric imperfections. The FE models established show good agreement with the experimental test in terms of ultimate bending strength, moment vs. mid-span deflection response, and failure modes.

Published
2021
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5. Clinical use of thrombin generation assays

Author

François Depasse, Peter Turecek, Thomas Dr. Wissel, Julia Mueller, Björn Hermes, Matthias Germer, Nikolaus B Binder, and Stephan Schwers

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, SARS-CoV-2, medicine.drug_class, business.industry, Anticoagulant, Thrombin, COVID-19, Hematology, Blood Coagulation Disorders, Bioinformatics, medicine.disease, Thrombosis, Review article, Breast cancer, Coagulation, Hemostasis, medicine, Humans, Blood Coagulation Tests, Neoplasm Recurrence, Local, business, medicine.drug, Blood coagulation test
Abstract

Determining patient's coagulation profile, i.e. detecting a bleeding tendency or the opposite, a thrombotic risk, is crucial for clinicians in many situations. Routine coagulation assays and even more specialized tests may not allow a relevant characterization of the hemostatic balance. In contrast, thrombin generation assay (TGA) is a global assay allowing the dynamic continuous and simultaneous recording of the combined effects of both thrombin generation and thrombin inactivation. TGA thus reflects the result of procoagulant and anticoagulant activities in blood and plasma. Because of this unique feature, TGA has been widely used in a wide array of settings from both research, clinical and pharmaceutical perspectives. This includes diagnosis, prognosis, prophylaxis, and treatment of inherited and acquired bleeding and thrombotic disorders. In addition, TGA has been shown to provide relevant information for the diagnosis of coagulopathies induced by infectious diseases, comprising also disturbance of the coagulation system in COVID-19, or for the assessment of early recurrence in breast cancer. This review article aims to document most clinical applications of TGA.

Published
2021
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6. Case Report: Invasive Sinusitis due to Sporothrix Brasiliensis in a Renal Transplant Recipient

Author

Maria Alice Barcellos, Maria Júlia Correia Lima Nepomuceno Araújo, Irene Faria Duayer, Hermes Higashino, Osni Braga, Vinicius Ponzio, Antonio Carlos Campos Pignatari, Anderson Messias Rodrigues, and Camila Hitome Nihei

Subjects
Adult, medicine.medical_specialty, Antifungal Agents, Article, Postoperative Complications, Virology, Biopsy, Humans, Medicine, Sinusitis, Sinus (anatomy), Mycosis, biology, medicine.diagnostic_test, Sporotrichosis, business.industry, Sporothrix, Mucormycosis, Triazoles, biology.organism_classification, medicine.disease, Kidney Transplantation, Dermatology, Transplant Recipients, Treatment Outcome, Infectious Diseases, medicine.anatomical_structure, Female, Parasitology, business, Brazil, Rare disease
Abstract

Sporotrichosis is usually a subcutaneous infection caused by thermodimorphic fungi of the genus Sporothrix. The disease occurs worldwide, but endemic areas are located in tropical and subtropical regions. The epidemiology of sporotrichosis in Brazil is peculiar because of the cat’s entry in the chain of transmission of this mycosis, associated with Sporothrix brasiliensis, the most virulent species in the genus. Sinusitis caused by Sporothrix species is unusual and may be underdiagnosed or confused with other fungal etiologies, like mucormycosis. We report a case of sinusitis due to a Sporothrix species in a 6-year renal transplant recipient. Direct examination of smears of exudate of the sinus specimen (aspirate, biopsy) revealed budding yeasts and cigar-shaped cells. Sporothrix was subsequently recovered from the patient’s exudate culture and identified as S. brasiliensis using species-specific polymerase chain reaction, and she was successfully treated with antifungal therapy. Her parents also developed the disease a week later, both only cutaneous involvement. Sporotrichosis sinusitis is a rare disease, even in immunocompromised patients. Diagnosis is crucial, and benefits from good epidemiological history.

Published
2021
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8. Experimental and numerical study on CFS composite beams with riveted shear connectors

Author

João Victor Fragoso Dias, Hermes Carvalho, Karen Aparecida Freitas Peroni Maia, Francisco Carlos Rodrigues, and Rodrigo Barreto Caldas

Subjects
Materials science, business.industry, 0211 other engineering and technologies, Stiffness, 020101 civil engineering, 02 engineering and technology, Building and Construction, Thread (computing), Structural engineering, Finite element method, 0201 civil engineering, Shear (sheet metal), Cable gland, 021105 building & construction, Architecture, Rivet, Slab, medicine, medicine.symptom, Safety, Risk, Reliability and Quality, business, Beam (structure), Civil and Structural Engineering
Abstract

This paper presents a study on the development of a novel shear connector for usage on cold-formed steel–concrete composite beams. The connector consists of a bolt fixed to the steel profile by means of a tubular rivet with inner thread and can be installed with a single access, allowing usage on tubular sections. Four push-out tests and four full-scale beam tests were conducted, two with friction between the steel section and the slab and two without friction. A numerical analysis was also conducted to assess whether the beam behaviour could be simulated in the finite element commercial code ABAQUS. It was noted that the shear connectors were extremely flexible and presented very large slips. The connectors also presented enough strength to allow for the construction of composite beams with adequate shear interaction between the slab and the steel beam without an excessive number of connectors. Due to the high flexibility of the connectors, even though the beam was designed considering full shear interaction between the slab and the steel section, the observed values of strength and stiffness were not as high as calculated. Design codes should have their procedures reviewed to consider this flexibility, as only a strength requirement proved to be unsuitable, indicating that full shear interaction was not achieved. It was also observed that the presence of friction increased the interaction level of the beams.

Published
2021
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9. Cardiac rehabilitation availability and characteristics in Latin America and the Caribbean: A Global Comparison

Author

Felipe Araya-Ramirez, Briseida Benaim, Sherry L. Grace, Taslima Mamataz, Audry Chacin-Suarez, Hermes Lomelí, Jacqueline Hol, Francisco Lopez-Jimenez, Gerard Burdiat, Raquel Rodrigues Britto, Jose R. Medina-Inojosa, Dawn C. Scantlebury, Marta Supervia, Claudia Anchique-Santos, Richard Salmon, Rosalia Fernandez, Karam Turk-Adawi, and Graciela Gonzalez

Subjects
Burden of disease, Latin Americans, medicine.medical_treatment, Myocardial Ischemia, Cardiac rehabilitation, Disease, 030204 cardiovascular system & hematology, Multidisciplinary team, Health Services Accessibility, Insurance Coverage, global comparison, 03 medical and health sciences, 0302 clinical medicine, Cost of Illness, medicine, Humans, 030212 general & internal medicine, Patient Care Team, Cardiac Rehabilitation, Rehabilitation, business.industry, Incidence, Incidence (epidemiology), Cardiovascular disease, Cross-Sectional Studies, Latin America, Caribbean Region, latin America, Health Expenditures, Cardiology and Cardiovascular Medicine, business, Ischemic heart, Demography
Abstract

This study aimed to establish availability and characteristics of cardiac rehabilitation (CR) in Latin America and the Caribbean (LAC), where cardiovascular disease is highly prevalent. In this cross-sectional sub-analysis focusing on the 35 LAC countries, local cardiovascular societies identified CR programs globally. An online survey was administered to identified programs, assessing capacity and characteristics. CR need was computed relative to ischemic heart disease (IHD) incidence from the Global Burden of Disease study. ≥1 CR program was identified in 24 LAC countries (68.5% availability; median = 3 programs/country). Data were collected in 20/24 countries (83.3%); 139/255 programs responded (54.5%), and compared to responses from 1082 programs in 111 countries. LAC density was 1 CR spot per 24 IHD patients/year (vs 18 globally). Greatest need was observed in Brazil, Dominican Republic and Mexico (all with >150,000 spots needed/year). In 62.8% (vs 37.2% globally P < .001) of CR programs, patients pay out-of-pocket for some or all of CR. CR teams were comprised of a mean of 5.0 ± 2.3 staff (vs 6.0 ± 2.8 globally; P < .001); Social workers, dietitians, kinesiologists, and nurses were significantly less common on CR teams than globally. Median number of core components offered was 8 (vs 9 globally; P < .001). Median dose of CR was 36 sessions (vs 24 globally; P < .001). Only 27 (20.9%) programs offered alternative CR models (vs 31.1% globally; P < .01). In LAC countries, there is very limited CR capacity in relation to need. CR dose is high, but comprehensiveness low, which could be rectified with a more multidisciplinary team.

Published
2021
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10. Neighborhood Socioeconomic Disadvantage and Mortality Among Medicare Beneficiaries Hospitalized for Acute Myocardial Infarction, Heart Failure, and Pneumonia

Author

Changyu Shen, Rishi K. Wadhera, Robert W. Yeh, Yuansong Zhao, Karen E. Joynt Maddox, and Zachary Hermes

Subjects
Population, Myocardial Infarction, Medicare, Internal Medicine, Humans, Medicine, Myocardial infarction, education, Aged, Retrospective Studies, Original Research, Heart Failure, education.field_of_study, business.industry, Mortality rate, Pneumonia, Odds ratio, medicine.disease, United States, Health equity, Disadvantaged, Hospitalization, Socioeconomic Factors, business, Medicaid, Demography
Abstract

BACKGROUND: The Centers for Medicare and Medicaid Services’ Hospital Value-Based Purchasing program uses 30-day mortality rates for acute myocardial infarction, heart failure, and pneumonia to evaluate US hospitals, but does not account for neighborhood socioeconomic disadvantage when comparing their performance. OBJECTIVE: To determine if neighborhood socioeconomic disadvantage is associated with worse 30-day mortality rates after a hospitalization for acute myocardial infarction (AMI), heart failure (HF), or pneumonia in the USA, as well as within the subset of counties with a high proportion of Black individuals. DESIGN AND PARTICIPANTS: This retrospective, population-based study included all Medicare fee-for-service beneficiaries aged 65 years or older hospitalized for acute myocardial infarction, heart failure, or pneumonia between 2012 and 2015. EXPOSURE: Residence in most socioeconomically disadvantaged vs. less socioeconomically disadvantaged neighborhoods as measured by the area deprivation index (ADI). MAIN MEASURE(S): All-cause mortality within 30 days of admission. KEY RESULTS: The study included 3,471,592 Medicare patients. Of these patients, 333,472 resided in most disadvantaged neighborhoods and 3,138,120 in less disadvantaged neighborhoods. Patients living in the most disadvantaged neighborhoods were younger (78.4 vs. 80.0 years) and more likely to be Black adults (24.6% vs. 7.5%) and dually enrolled in Medicaid (39.4% vs. 21.8%). After adjustment for demographics (age, sex, race/ethnicity), poverty, and clinical comorbidities, 30-day mortality was higher among beneficiaries residing in most disadvantaged neighborhoods for AMI (adjusted odds ratio 1.08, 95% CI 1.06–1.11) and pneumonia (aOR 1.05, 1.03–1.07), but not for HF (aOR 1.02, 1.00–1.04). These patterns were similar within the subset of US counties with a high proportion of Black adults (AMI, aOR 1.07, 1.03–1.11; HF 1.02, 0.99–1.05; pneumonia 1.03, 1.00–1.07). CONCLUSIONS: Neighborhood socioeconomic disadvantage is associated with higher 30-day mortality for some conditions targeted by value-based programs, even after accounting for individual-level demographics, clinical comorbidities, and poverty. These findings may have implications as policymakers weigh strategies to advance health equity under value-based programs. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11606-021-07090-z.

Published
2021
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12. Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Author

Niamh Mullins, JooEun Kang, Adrian I. Campos, Jonathan R.I. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark Adams, Swapnil Awasthi, Michael Gandal, Jonathan D. Hafferty, Akitoyo Hishimoto, Minsoo Kim, Satoshi Okazaki, Ikuo Otsuka, Stephan Ripke, Erin B. Ware, Andrew W. Bergen, Wade H. Berrettini, Martin Bohus, Harry Brandt, Xiao Chang, Wei J. Chen, Hsi-Chung Chen, Steven Crawford, Scott Crow, Emily DiBlasi, Philibert Duriez, Fernando Fernández-Aranda, Manfred M. Fichter, Steven Gallinger, Stephen J. Glatt, Philip Gorwood, Yiran Guo, Hakon Hakonarson, Katherine A. Halmi, Hai-Gwo Hwu, Sonia Jain, Stéphane Jamain, Susana Jiménez-Murcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Kelly L. Klump, Dong Li, Shih-Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Chih-Min Liu, Pierre J. Magistretti, Christian R. Marshall, James E. Mitchell, Eric T. Monson, Richard M. Myers, Dalila Pinto, Abigail Powers, Nicolas Ramoz, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Michael Strober, Laura M. Thornton, Janet Treasure, Ming T. Tsuang, Stephanie H. Witt, D. Blake Woodside, Zeynep Yilmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Tracy M. Air, Martin Alda, Lars Alfredsson, Ole A. Andreassen, Adebayo Anjorin, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M. Helena Azevedo, Nicholas Bass, Claiton H.D. Bau, Bernhard T. Baune, Frank Bellivier, Klaus Berger, Joanna M. Biernacka, Tim B. Bigdeli, Elisabeth B. Binder, Michael Boehnke, Marco P. Boks, Rosa Bosch, David L. Braff, Richard Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Miguel Casas, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Sven Cichon, Aiden Corvin, Nicholas Craddock, David Craig, Franziska Degenhardt, Srdjan Djurovic, Howard J. Edenberg, Ayman H. Fanous, Jerome C. Foo, Andreas J. Forstner, Mark Frye, Janice M. Fullerton, Justine M. Gatt, Pablo V. Gejman, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugenio H. Grevet, Maria Grigoroiu-Serbanescu, Blanca Gutierrez, Jose Guzman-Parra, Steven P. Hamilton, Marian L. Hamshere, Annette Hartmann, Joanna Hauser, Stefanie Heilmann-Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa A. Jones, Lina Jonsson, René S. Kahn, John R. Kelsoe, Kenneth S. Kendler, Stefan Kloiber, Karestan C. Koenen, Manolis Kogevinas, Bettina Konte, Marie-Odile Krebs, Mikael Landén, Jacob Lawrence, Marion Leboyer, Phil H. Lee, Douglas F. Levinson, Calwing Liao, Jolanta Lissowska, Susanne Lucae, Fermin Mayoral, Susan L. McElroy, Patrick McGrath, Peter McGuffin, Andrew McQuillin, Sarah E. Medland, Divya Mehta, Ingrid Melle, Yuri Milaneschi, Philip B. Mitchell, Esther Molina, Gunnar Morken, Preben Bo Mortensen, Bertram Müller-Myhsok, Caroline Nievergelt, Vishwajit Nimgaonkar, Markus M. Nöthen, Michael C. O’Donovan, Roel A. Ophoff, Michael J. Owen, Carlos Pato, Michele T. Pato, Brenda W.J.H. Penninx, Jonathan Pimm, Giorgio Pistis, James B. Potash, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos-Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea Roberts, Gloria Roberts, Guy A. Rouleau, Diego L. Rovaris, Dan Rujescu, Cristina Sánchez-Mora, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Stanley I. Shyn, Lea Sirignano, Pamela Sklar, Olav B. Smeland, Jordan W. Smoller, Edmund J.S. Sonuga-Barke, Gianfranco Spalletta, John S. Strauss, Beata Świątkowska, Maciej Trzaskowski, Gustavo Turecki, Laura Vilar-Ribó, John B. Vincent, Henry Völzke, James T.R. Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Naomi R. Wray, Clement C. Zai, Allison E. Ashley-Koch, Jean C. Beckham, Elizabeth R. Hauser, Michael A. Hauser, Nathan A. Kimbrel, Jennifer H. Lindquist, Benjamin McMahon, David W. Oslin, Xuejun Qin, Esben Agerbo, Anders D. Børglum, Gerome Breen, Annette Erlangsen, Tõnu Esko, Joel Gelernter, David M. Hougaard, Ronald C. Kessler, Henry R. Kranzler, Qingqin S. Li, Nicholas G. Martin, Andrew M. McIntosh, Ole Mors, Merete Nordentoft, Catherine M. Olsen, David Porteous, Robert J. Ursano, Danuta Wasserman, Thomas Werge, David C. Whiteman, Cynthia M. Bulik, Hilary Coon, Ditte Demontis, Anna R. Docherty, Po-Hsiu Kuo, Cathryn M. Lewis, J. John Mann, Miguel E. Rentería, Daniel J. Smith, Eli A. Stahl, Murray B. Stein, Fabian Streit, Virginia Willour, Douglas M. Ruderfer, Manuel Mattheisen, Abdel Abdellaoui, Mark J. Adams, Till F.M. Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan T.F. Beekman, Julien Bryois, Henriette N. Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Jane Hvarregaard Christensen, Toni-Kim Clarke, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Nick Craddock, Gregory E. Crawford, Gail Davies, Eske M. Derks, Nese Direk, Conor V. Dolan, Erin C. Dunn, Thalia C. Eley, Valentina Escott-Price, Farnush Farhadi Hassan Kiadeh, Hilary K. Finucane, Josef Frank, Héléna A. Gaspar, Michael Gill, Fernando S. Goes, Scott D. Gordon, Shantel Marie Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Yang Wu, Hualin S. Xi, Jian Yang, Futao Zhang, Volker Arolt, Dorret I. Boomsma, Udo Dannlowski, E.J.C. de Geus, J. Raymond Depaulo, Enrico Domenici, Katharina Domschke, Jakob Grove, Lynsey S. Hall, Christine Søholm Hansen, Thomas F. Hansen, Stefan Herms, Ian B. Hickie, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David M. Howard, Rick Jansen, Eric Jorgenson, James A. Knowles, Isaac S. Kohane, Julia Kraft, Warren W. Kretzschmar, Zoltán Kutalik, Yihan Li, Penelope A. Lind, Donald J. MacIntyre, Dean F. MacKinnon, Robert M. Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Christel M. Middeldorp, Evelin Mihailov, Lili Milani, Francis M. Mondimore, Grant W. Montgomery, Sara Mostafavi, Matthias Nauck, Bernard Ng, Michel G. Nivard, Dale R. Nyholt, Paul F. O’Reilly, Hogni Oskarsson, Caroline Hayward, Andrew C. Heath, Glyn Lewis, Pamela A.F. Madden, Patrik K. Magnusson, Andres Metspalu, Sara A. Paciga, Nancy L. Pedersen, Jodie N. Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E. Peterson, Wouter J. Peyrot, Danielle Posthuma, Jorge A. Quiroz, Per Qvist, John P. Rice, Brien P. Riley, Saira Saeed Mirza, Robert Schoevers, Eva C. Schulte, Ling Shen, Engilbert Sigurdsson, Grant C.B. Sinnamon, Johannes H. Smit, Hreinn Stefansson, Stacy Steinberg, Jana Strohmaier, Katherine E. Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa A. Thomson, Thorgeir E. Thorgeirsson, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G. Uitterlinden, Daniel Umbricht, Albert M. van Hemert, Alexander Viktorin, Peter M. Visscher, Yunpeng Wang, Bradley T. Webb, Roy H. Perlis, David J. Porteous, Catherine Schaefer, Kari Stefansson, Henning Tiemeier, Rudolf Uher, Patrick F. Sullivan, Kevin S. O’Connell, Brandon Coombes, Zhen Qiao, Thomas D. Als, Sigrid Børte, Alexander W. Charney, Ole Kristian Drange, Michael J. Gandal, Saskia P. Hagenaars, Masashi Ikeda, Nolan Kamitaki, Kristi Krebs, Georgia Panagiotaropoulou, Brian M. Schilder, Laura G. Sloofman, Bendik S. Winsvold, Hong-Hee Won, Liliya Abramova, Kristina Adorjan, Mariam Al Eissa, Diego Albani, Ney Alliey-Rodriguez, Verneri Antilla, Anastasia Antoniou, Ji Hyun Baek, Michael Bauer, Eva C. Beins, Sarah E. Bergen, Armin Birner, Erlend Bøen, Murielle Brum, Ben M. Brumpton, Nathalie Brunkhorst-Kanaan, William Byerley, Murray Cairns, Miquel Casas, Pablo Cervantes, Cristiana Cruceanu, Alfredo Cuellar-Barboza, Julie Cunningham, David Curtis, Piotr M. Czerski, Anders M. Dale, Nina Dalkner, Friederike S. David, Amanda L. Dobbyn, Athanassios Douzenis, Torbjørn Elvsåshagen, I. Nicol Ferrier, Alessia Fiorentino, Tatiana M. Foroud, Liz Forty, Oleksandr Frei, Nelson B. Freimer, Louise Frisén, Katrin Gade, Julie Garnham, Ian R. Gizer, Katherine Gordon-Smith, Tiffany A. Greenwood, José Guzman-Parra, Kyooseob Ha, Magnus Haraldsson, Martin Hautzinger, Urs Heilbronner, Dennis Hellgren, Peter A. Holmans, Laura Huckins, Jessica S. Johnson, Janos L. Kalman, Yoichiro Kamatani, Sarah Kittel-Schneider, Maria Koromina, Thorsten M. Kranz, Michiaki Kubo, Ralph Kupka, Steven A. Kushner, Catharina Lavebratt, Markus Leber, Heon-Jeong Lee, Shawn E. Levy, Catrin Lewis, Martin Lundberg, Sigurdur H. Magnusson, Adam Maihofer, Dolores Malaspina, Eirini Maratou, Lina Martinsson, Nathaniel W. McGregor, James D. McKay, Helena Medeiros, Vincent Millischer, Jennifer L. Moran, Derek W. Morris, Thomas W. Mühleisen, Niamh O’Brien, Claire O’Donovan, Loes M. Olde Loohuis, Lilijana Oruc, Sergi Papiol, Antonio F. Pardiñas, Amy Perry, Andrea Pfennig, Evgenia Porichi, Towfique Raj, Mark H. Rapaport, J. Raymond DePaulo, Eline J. Regeer, Fabio Rivas, Julian Roth, Panos Roussos, Fanny Senner, Sally Sharp, Paul D. Shilling, Claire Slaney, Janet L. Sobell, Maria Soler Artigas, Anne T. Spijker, Dan J. Stein, Chikashi Terao, Claudio Toma, Paul Tooney, Evangelia-Eirini Tsermpini, Marquis P. Vawter, Helmut Vedder, Simon Xi, Wei Xu, Jessica Mei Kay Yang, Allan H. Young, Hannah Young, Peter P. Zandi, Hang Zhou, null HUNT All-In Psychiatry, Gulja Babadjanova, Lena Backlund, Susanne Bengesser, Douglas H.R. Blackwood, Vaughan J. Carr, Stanley Catts, Dimitris Dikeos, Bruno Etain, Panagiotis Ferentinos, Micha Gawlik, Elliot S. Gershon, Frans Henskens, Jan Hillert, Kyung Sue Hong, Christina M. Hultman, Kristian Hveem, Nakao Iwata, Assen V. Jablensky, George Kirov, Christine Lochner, Carmel Loughland, Carol A. Mathews, Francis J. McMahon, Patricia Michie, Bryan Mowry, Benjamin M. Neale, Caroline M. Nievergelt, Ketil J. Oedegaard, Tomas Olsson, Chris Pantelis, George P. Patrinos, Eva Z. Reininghaus, Takeo Saito, Ulrich Schall, Martin Schalling, Rodney J. Scott, Eystein Stordal, Arne E. Vaaler, Eduard Vieta, Irwin D. 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J., Wasserman, D., Coon, H., Demontis, D., Docherty, A. R., Kuo, P. -H., Mann, J. J., Renteria, M. E., Stein, M. B., Willour, V., Psychiatry, Biological Psychology, APH - Methodology, APH - Mental Health, APH - Health Behaviors & Chronic Diseases, AMS - Sports, AMS - Ageing & Vitality, APH - Personalized Medicine, Amsterdam Neuroscience - Complex Trait Genetics, Complex Trait Genetics, Institute for Molecular Medicine Finland, Centre of Excellence in Complex Disease Genetics, Aarno Palotie / Principal Investigator, Genomics of Neurological and Neuropsychiatric Disorders, HUS Psychiatry, Department of Public Health, Clinicum, Nuorisopsykiatria, Faculty Common Matters (Faculty of Social Sciences), Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Biostatistics Helsinki, Anna Keski-Rahkonen / Principal Investigator, Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation, Internal medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Mullins N., Kang J., Campos A.I., Coleman J.R.I., Edwards 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Nyholt D.R., O'Reilly P.F., Oskarsson H., Hayward C., Heath A.C., Lewis G., Li Q.S., Madden P.A.F., Magnusson P.K., Martin N.G., McIntosh A.M., Metspalu A., Mors O., Nordentoft M., Paciga S.A., Pedersen N.L., Painter J.N., Pedersen C.B., Pedersen M.G., Peterson R.E., Peyrot W.J., Posthuma D., Quiroz J.A., Qvist P., Rice J.P., Riley B.P., Mirza S.S., Schoevers R., Schulte E.C., Shen L., Sigurdsson E., Sinnamon G.C.B., Smit J.H., Smith D.J., Stefansson H., Steinberg S., Streit F., Strohmaier J., Tansey K.E., Teismann H., Teumer A., Thompson W., Thomson P.A., Thorgeirsson T.E., Traylor M., Treutlein J., Trubetskoy V., Uitterlinden A.G., Umbricht D., der Auwera S.V., van Hemert A.M., Viktorin A., Visscher P.M., Wang Y., Webb B.T., Perlis R.H., Porteous D.J., Schaefer C., Stefansson K., Tiemeier H., Uher R., Werge T., Lewis C.M., Breen G., Borglum A.D., Sullivan P.F., O'Connell K.S., Coombes B., Qiao Z., Als T.D., Borte S., Charney A.W., Drange O.K., Gandal M.J., Hagenaars S.P., Ikeda M., Kamitaki N., Krebs K., Panagiotaropoulou G., Schilder B.M., Sloofman L.G., Winsvold B.S., Won H.-H., Abramova L., Adorjan K., Al Eissa M., Albani D., Alliey-Rodriguez N., Antilla V., Antoniou A., Baek J.H., Bauer M., Beins E.C., Bergen S.E., Birner A., Boen E., Brum M., Brumpton B.M., Brunkhorst-Kanaan N., Byerley W., Cairns M., Cervantes P., Cruceanu C., Cuellar-Barboza A., Cunningham J., Curtis D., Czerski P.M., Dale A.M., Dalkner N., David F.S., Dobbyn A.L., Douzenis A., Elvsashagen T., Ferrier I.N., Fiorentino A., Foroud T.M., Forty L., Frei O., Freimer N.B., Frisen L., Gade K., Garnham J., Gelernter J., Gizer I.R., Gordon-Smith K., Greenwood T.A., Ha K., Haraldsson M., Hautzinger M., Heilbronner U., Hellgren D., Holmans P.A., Huckins L., Johnson J.S., Kalman J.L., Kamatani Y., Kittel-Schneider S., Koromina M., Kranz T.M., Kranzler H.R., Kubo M., Kupka R., Kushner S.A., Lavebratt C., Leber M., Lee H.-J., Levy S.E., Lewis C., Lundberg M., Magnusson S.H., Maihofer A., Malaspina D., Maratou E., Martinsson L., McGregor N.W., McKay J.D., Medeiros H., Millischer V., Moran J.L., Morris D.W., Muhleisen T.W., O'Brien N., O'Donovan C., Olde Loohuis L.M., Oruc L., Papiol S., Pardinas A.F., Perry A., Pfennig A., Porichi E., Raj T., Rapaport M.H., Regeer E.J., Rivas F., Roth J., Roussos P., Ruderfer D.M., Senner F., Sharp S., Shilling P.D., Slaney C., Sobell J.L., Artigas M.S., Spijker A.T., Stein D.J., Terao C., Toma C., Tooney P., Tsermpini E.-E., Vawter M.P., Vedder H., Xi S., Xu W., Kay Yang J.M., Young A.H., Young H., Zandi P.P., Zhou H., HUNT All-In Psychiatry, Babadjanova G., Backlund L., Bengesser S., Blackwood D.H.R., Carr V.J., Catts S., Dikeos D., Etain B., Ferentinos P., Gawlik M., Gershon E.S., Henskens F., Hillert J., Hong K.S., Hultman C.M., Hveem K., Iwata N., Jablensky A.V., Kirov G., Lochner C., Loughland C., Mathews C.A., McMahon F.J., Michie P., Mowry B., Neale B.M., Nievergelt C.M., Oedegaard K.J., Olsson T., Pantelis C., Patrinos G.P., Reininghaus E.Z., Saito T., Schall U., Schalling M., Scott R.J., Weickert C.S., Stordal E., Vaaler A.E., Vieta E., Waldman I.D., Zwart J.-A., Nurnberger J.I., Stahl E.A., Di Florio A., Adan R.A.H., Ando T., Aschauer H., Baker J.H., Bencko V., Birgegard A., Boden J.M., Boehm I., Boni C., Perica V.B., Buehren K., Bulik C.M., Burghardt R., Carlberg L., Cassina M., Clementi M., Cone R.D., Courtet P., Crowley J.J., Danner U.N., Davis O.S.P., de Zwaan M., Dedoussis G., Degortes D., DeSocio J.E., Dick D.M., Dina C., Dmitrzak-Weglarz M., Martinez E.D., Duncan L.E., Egberts K., Mattingsdal M., McDevitt S., Meulenbelt I., Micali N., Mitchell J., Mitchell K., Monteleone P., Monteleone A.M., Munn-Chernoff M.A., Nacmias B., Navratilova M., Ntalla I., Olsen C.M., O'Toole J.K., Padyukov L., Palotie A., Pantel J., Papezova H., Parker R., Pearson J.F., Ehrlich S., Escaramis G., Espeseth T., Estivill X., Farmer A., Favaro A., Fischer K., Floyd J.A.B., Focker M., Foretova L., Forzan M., Franklin C.S., Gambaro G., Giuranna J., Giusti-Rodriquez P., Gonidakis F., Gordon S., Mayora M.G., Guillaume S., Hanscombe K.B., Hatzikotoulas K., Hebebrand J., Helder S.G., Henders A.K., Herpertz-Dahlmann B., Herzog W., Hinney A., Horwood L.J., Hubel C., Petersen L.V., Purves K.L., Raevuori A., Reichborn-Kjennerud T., Ricca V., Ripatti S., Ritschel F., Roberts M., Rybakowski F., Santonastaso P., Scherag A., Schmidt U., Schork N.J., Schosser A., Seitz J., Slachtova L., Slagboom P.E., Slof-Op 't Landt M.C.T., Slopien A., Soranzo N., Sorbi S., Southam L., Steen V.W., Huckins L.M., Hudson J.I., Imgart H., Inoko H., Janout V., Jordan J., Julia A., Kalsi G., Kaminska D., Kaprio J., Karhunen L., Karwautz A., Kas M.J.H., Kennedy M.A., Keski-Rahkonen A., Kiezebrink K., Kim Y.-R., Kirk K.M., Klareskog L., Knudsen G.P.S., Larsen J.T., Le Hellard S., Leppa V.M., Lichtenstein P., Lin B.D., Lundervold A., Luykx J., Maj M., Mannik K., Marsal S., Stuber G.D., Szatkiewicz J.P., Tachmazidou I., Tenconi E., Tortorella A., Tozzi F., Tsitsika A., Tyszkiewicz-Nwafor M., Tziouvas K., van Elburg A.A., van Furth E.F., Wade T.D., Wagner G., Walton E., Whiteman D.C., Wichmann H.E., Widen E., Yao S., Zeggini E., Zerwas S., Zipfel S., Jungkunz M., Dietl L., Schwarze C.E., Dahmen N., Schott B.H., Mobascher A., Crivelli S., Dennis M.F., Harvey P.D., Carter B.W., Huffman J.E., Jacobson D., Madduri R., Olsen M.K., Pestian J., Gaziano J.M., Muralidhar S., Ramoni R., Beckham J., Chang K.-M., O'Donnell C.J., Tsao P.S., Breeling J., Huang G., Romero J.P.C., Moser J., Whitbourne S.B., Brewer J.V., Aslan M., Connor T., Argyres D.P., Stephens B., Brophy M.T., Humphries D.E., Selva L.E., Do N., Shayan S., Cho K., Pyarajan S., Hauser E., Sun Y., Zhao H., Wilson P., McArdle R., Dellitalia L., Mattocks K., Harley J., Zablocki C.J., Whittle J., Jacono F., Gutierrez S., Gibson G., Hammer K., Kaminsky L., Villareal G., Kinlay S., Xu J., Hamner M., Mathew R., Bhushan S., Iruvanti P., Godschalk M., Ballas Z., Ivins D., Mastorides S., Moorman J., Gappy S., Klein J., Ratcliffe N., Florez H., Okusaga O., Murdoch M., Sriram P., Yeh S.S., Tandon N., Jhala D., Aguayo S., Cohen D., Sharma S., Liangpunsakul S., Oursler K.A., Whooley M., Ahuja S., Constans J., Meyer P., Greco J., Rauchman M., Servatius R., Gaddy M., Wallbom A., Morgan T., Stapley T., Sherman S., Ross G., Tsao P., Strollo P., Boyko E., Meyer L., Gupta S., Huq M., Fayad J., Hung A., Lichy J., Hurley R., Robey B., Striker R., Erlangsen A., Kessler R.C., Porteous D., Ursano R.J., Wasserman D., Coon H., Demontis D., Docherty A.R., Kuo P.-H., Mann J.J., Renteria M.E., Stein M.B., and Willour V.

Subjects
LD SCORE REGRESSION, Genome-wide association study, Suicide, Attempted, 3124 Neurology and psychiatry, 0302 clinical medicine, Risk Factors, Insomnia, Suicide attempt, GWAS, Suïcidi, Depression (differential diagnoses), Cause of death, Psychiatry, 0303 health sciences, Factors de risc en les malalties, Mental Disorders, Genetic Correlation, Genome-wide Association Study, Pleiotropy, Polygenicity, Suicide, Suicide Attempt, DEPRESSION, 3. Good health, Genetic correlation, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Depressive Disorder, Major, Mental illness, Cohort, SEX, medicine.symptom, Human, medicine.medical_specialty, Risk factors in diseases, BF, Locus (genetics), BEHAVIORS, Psykiatri, EVENTS, 03 medical and health sciences, SDG 3 - Good Health and Well-being, medicine, ddc:610, GENOME-WIDE ASSOCIATION, IDEATION, Socioeconomic status, METAANALYSIS, Biological Psychiatry, 030304 developmental biology, business.industry, Risk Factor, Genetic architecture, THOUGHTS, RC0321, business, Malalties mentals, 030217 neurology & neurosurgery
Abstract

Statistical analyses were carried out on the NL Genetic Cluster Computer (http://www.geneticcluster.org) hosted by SURFsara and the Mount Sinai high performance computing cluster (http://hpc.mssm.edu), which is supported by the Office of Research Infrastructure of the National Institutes of Health (Grant Nos. S10OD018522 and S10OD026880). This work was conducted in part using the resources of the Advanced Computing Center for Research and Education at Vanderbilt University, Nashville, TN. This work was funded by the National Institutes of Health (Grant Nos. R01MH116269 and R01MH121455 [to DMR]), NIGMS of the National Institutes of Health (Grant No. T32GM007347 [to JK]), and the Brain & Behavior Research Foundation (NARSAD Young Investigator Award No. 29551 [to NM])., BACKGROUND: Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. METHODS: We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. RESULTS: Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. CONCLUSIONS: Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders., Office of Research Infrastructure of the National Institutes of Health S10OD018522 S10OD026880, United States Department of Health & Human Services, National Institutes of Health (NIH) - USA R01MH116269 R01MH121455, NIH National Institute of General Medical Sciences (NIGMS) T32GM007347 NARSAD 29551

Published
2022
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13. Maternal SARS-CoV-2 infection during pregnancy: possible impact on the infant

Author

Sven Kehl, Joachim Woelfle, Johanna Hammersen, Christian Y. Mardin, Antje Neubert, Jörg Jüngert, Patrick Morhart, Holm Schneider, Michael Schneider, Alexander Hein, Wolfgang Schuh, Katharina Hermes, Manfred Rauh, and Sigrun Maier-Wohlfart

Subjects
Male, Pediatrics, medicine.medical_specialty, COVID-19 Vaccines, Short Communication, Rubella, Pregnancy, Case report, medicine, Humans, ddc:610, Pregnancy Complications, Infectious, Malformation, Optic nerve hypoplasia, SARS-CoV-2, business.industry, Transmission (medicine), Infant, Newborn, Pregnancy Outcome, Materno-fetal transmission, COVID-19, medicine.disease, Infectious Disease Transmission, Vertical, Coronavirus, Vaccination, Embryopathy, Pediatrics, Perinatology and Child Health, Cohort, Gestation, Female, business, Retinopathy
Abstract

The risk and potential consequences of mother-to-child transmission of severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) during pregnancy are still a matter of debate. We studied the impact of SARS-CoV-2 infection on 56 complete households, including 27 newborns whose mothers were pregnant when exposed to the virus. Two PCR-confirmed perinatal SARS-CoV-2 transmissions with mild symptoms in affected neonates were recorded. In addition, we observed a severe eye malformation (unilateral microphthalmia, optic nerve hypoplasia, and congenital retinopathy) associated with maternal SARS-CoV-2 infection in weeks 5 and 6 of embryonic development. This embryopathy could not be explained by other infectious agents, genetic factors, drug use, or maternal disease during pregnancy. Eight other women with a history of SARS-CoV-2 infection prior to gestational week 12, however, delivered healthy infants.Conclusion: The repeated occurrence of mother-to-child transmission in our cohort with risks that remain incompletely understood, such as long-term effects and the possibility of an embryopathy, should sensitize researchers and stimulate further studies as well as support COVID-19 vaccination recommendations for pregnant women. Trial registration number: NCT04741412. Date of registration: November 18, 2020 What is Known:•Materno-fetal transmission of severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) during pregnancy has rarely been reported so far, but was demonstrated in isolated cases. What is New:•In a study of complete households with documented SARS-CoV-2 infection, including a cohort of pregnant women, we observed perinatal coronavirus transmission at a higher frequency than expected.•We also describe a newborn boy with an eye malformation reminiscent of rubella embryopathy but associated with early gestation SARS-CoV-2 infection of his mother.•A coronavirus-related embryopathy, reported here for the first time, is a finding that requires further investigation.

Published
2021
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14. Qualitätssicherung bei hämatoonkologischen Schwerpunktpraxen

Author

Hermes-Moll K, Osburg S, Heidt, and Walawgo T

Subjects
Medical education, Quality management, business.industry, media_common.quotation_subject, Hematology, Certification, Clinical trial, Presentation, Quality management system, Oncology, Professional association, Quality (business), Psychology, business, Quality assurance, media_common
Abstract

Background The regularly published quality reports of the haemato-oncology specialist practices primarily include billing data and results of patient and staff surveys as well as current project-related results. In order to obtain further information on structural quality, an additional survey was conducted among haemato-oncology practices. Objectives The goals are the analysis and presentation of structural quality characteristics of haemato-oncology specialist practices. Methods We performed an online survey of practices with at least one member in the Professional Association of Office-based Haematologists and Oncologists in Germany in 2019 on practice characteristics, professional policy issues, quality management, and networking. Results Of 372 practices contacted, 130 participated in the structural data survey (35%). Regarding the topics of quality management and networking, the data show that more than 60% of the practices have a certified quality management system. Almost all practices (94%) are contracted to at least one certified centre and regularly participate in tumour conferences (98%). Furthermore, 77% of the practices participate in clinical trials. Conclusions The results of the 2019 structural data survey provide insights into quality characteristics of haemato-oncology specialist practices and demonstrate a strong cross-sector networking of these practices in Germany.

Published
2021
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15. Blue rubber bleb nevus syndrome: Presentation of a case and review of the literature

Author

Rodrigo Zanabria Zarmienta, Jorge Alejandro Cadena Arteaga, Paula Andrea Nieto Lozano, Migdalia Zamirna Zuleny Lasso Anacona, Daniela Steffany Possos Obando, María Alejandra Palacios Rodríguez, Jenny Alexandra Jurado Pantoja, Hermes Albeiro Ortega Diaz, Diana Yulieth Ramírez Anacona, Madelen Alexandra Ortiz Cárdenas, Angela Maria Fajardo Arteaga, Fabricio Andres Lasso Andrade, and Viviana Lizeth Echeverry Morillo

Subjects
Gastrointestinal bleeding, Pathology, medicine.medical_specialty, Blue rubber bleb nevus syndrome, genetic structures, Anemia, Vascular malformations, R895-920, Case Report, 030218 nuclear medicine & medical imaging, Hemangioma, Medical physics. Medical radiology. Nuclear medicine, 03 medical and health sciences, 0302 clinical medicine, Medicine, Radiology, Nuclear Medicine and imaging, skin and connective tissue diseases, Blue nevus, Gastrointestinal tract, business.industry, Thyroid, medicine.disease, medicine.anatomical_structure, Iron-deficiency anemia, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Blue Rubber Bleb Nevus Syndrome, is a rare condition characterized by skin lesions caused by vascular malformations most frequently associated with lesions of the gastrointestinal tract, although rare, it can present with lesions in the central nervous system, thyroid, liver, spleen and lungs; common symptoms are: digestive tract bleeding and iron deficiency anemia. The main manifestation are skin lesions that are characterized by being button-like, with a bluish tint, covered by skin, called blue nevus with a rubbery consistency due to its rubber-like consistency. We present a case of Blue Rubber Bleb Nevus Syndrome with involvement in the central nervous and gastrointestinal systems.

Published
2021
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16. Association of Glycemia, Lipids, and Blood Pressure With Cognitive Performance in People With Type 2 Diabetes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)

Author

Elizabeth R. Seaquist, Heidi Krause-Steinrauf, José A. Luchsinger, Mary E. Larkin, Corinna Falck-Ytter, Jennifer J. Manly, Joshua I. Barzilay, Naji Younes, Hermes Florez, Rodica Pop-Busui, and Willy Marcos Valencia

Subjects
Research design, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Clinical Trials and Supportive Activities, Blood Pressure, Type 2 diabetes, Cardiovascular, Verbal learning, Medical and Health Sciences, Endocrinology & Metabolism, Cognition, [GRADE Research Group Investigators], Clinical Research, Diabetes mellitus, Internal medicine, Behavioral and Social Science, Diabetes Mellitus, Internal Medicine, medicine, Humans, Epidemiology/Health Services Research, Risk factor, Aged, Advanced and Specialized Nursing, business.industry, Diabetes, Middle Aged, GRADE Research Group, medicine.disease, Lipids, Cross-Sectional Studies, Blood pressure, Diabetes Mellitus, Type 2, Hypertension, Digit symbol substitution test, Female, business, Type 2
Abstract

OBJECTIVE Type 2 diabetes is a risk factor for cognitive impairment. We examined the relation of glycemia, lipids, blood pressure (BP), hypertension history, and statin use with cognition in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). RESEARCH DESIGN AND METHODS Cross-sectional analyses from GRADE at baseline examined the association of glycemia (hemoglobin A1c [HbA1c]), LDL, systolic BP (SBP) and diastolic BP (DBP), hypertension history, and statin use with cognition assessed by the Spanish English Verbal Learning Test, letter and animal fluency tests, and Digit Symbol Substitution Test (DSST). RESULTS Among 5,047 GRADE participants, 5,018 (99.4%) completed cognitive assessments. Their mean age was 56.7 ± 10.0 years, and 36.4% were women. Mean diabetes duration was 4.0 ± 2.7 years. HbA1c was not related to cognition. Higher LDL was related to modestly worse DSST scores, whereas statin use was related to modestly better DSST scores. SBP between 120 and 139 mmHg and DBP between 80 and 89 mmHg were related to modestly better DSST scores. Hypertension history was not related to cognition. CONCLUSIONS In people with type 2 diabetes of a mean duration of

Published
2021
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17. EVALUATION BYAN ENZIMATIC IMMUNOASSAY (ELISA) OFToxocara canis SEUDOCOELOMATIC FLUID ANTIGENS FOR DETECT SPECIFIC ANTIBODIES

Author

César Jara Campos, Hermes Escalante Añorga, and Adderly Benites Murrieta

Subjects
Marketing, biology, medicine.diagnostic_test, business.industry, Strategy and Management, biology.organism_classification, Virology, Specific antibody, Canis, Antigen, Immunoassay, Media Technology, medicine, General Materials Science, business
Published
2021
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18. Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients

Author

Maria Clara Saad Menezes, Luz Marina Gomez Gomez, Claudia de Lucena Moreira, Suely Kubo Ariga, Thais Martins de Lima, Júlio César Garcia de Alencar, Lucas Oliveira Marino, Niels Olsen Saraiva Camara, Julio Flávio Meirelles Marchini, Heraldo Possolo de Souza, Rodrigo Antonio Brandao, Agnes Araujo Sardinha Pinto, Hermes Vieira Barbeiro, and Alicia Dudy Muller Veiga

Subjects
Male, 0301 basic medicine, medicine.medical_treatment, Science, Pyrin domain, Article, 03 medical and health sciences, 0302 clinical medicine, Interferon, medicine, Humans, 030212 general & internal medicine, Receptor, Aged, Innate immunity, Mechanical ventilation, Toll-like receptor, Multidisciplinary, Innate immune system, business.industry, COVID-19, Middle Aged, Prognosis, Respiration, Artificial, Toll-Like Receptor 3, 030104 developmental biology, Gene Expression Regulation, Immunology, TLR3, TLR4, Cytokines, Medicine, Female, business, Biomarkers, medicine.drug
Abstract

The role of innate immunity in COVID-19 is not completely understood. Therefore, this study explored the impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection on the expression of Pattern Recognition Receptors (PRRs) in peripheral blood cells and their correlated cytokines. Seventy-nine patients with severe COVID-19 on admission, according to World Health Organization (WHO) classification, were divided into two groups: patients who needed mechanical ventilation and/or deceased (SEVERE, n = 50) and patients who used supplementary oxygen but not mechanical ventilation and survived (MILD, n = 29); a control group (CONTROL, n = 17) was also enrolled. In the peripheral blood, gene expression (mRNA) of Toll-like receptors (TLRs) 3, 4, 7, 8, and 9, retinoic-acid inducible gene I (RIGI), NOD-like receptor family pyrin domain containing 3 (NLRP3), interferon alpha (IFN-α), interferon beta (IFN-β), interferon gamma (IFN-γ), interferon lambda (IFN-λ), pro-interleukin(IL)-1β (pro-IL-1β), and IL-18 was determined on admission, between 5–9 days, and between 10–15 days. Circulating cytokines in plasma were also measured. When compared to the COVID-19 MILD group, the COVID-19 SEVERE group had lower expression of TLR3 and overexpression of TLR4.

Published
2021

19. Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates

Author

Greg Jensen, Vincent P. Ferrera, Nancy Kwon, Mark Burgess, Elisa E. Konofagou, Robin Ji, Fabian Munoz, Hermes A. S. Kamimura, Andrew F. Teich, Antonios N. Pouliopoulos, Alicia J McLuckie, Anna Meaney, and Yusuke Niimi

Subjects
0301 basic medicine, Primates, Neuronavigation, Science, Blood–brain barrier, Focused ultrasound, Article, 03 medical and health sciences, 0302 clinical medicine, Animal model, Cognition, Quantitative Trait, Heritable, medicine, Animals, Prefrontal cortex, Multidisciplinary, Microbubbles, Human studies, Microglia, Behavior, Animal, business.industry, Biological Transport, Magnetic Resonance Imaging, Safety profile, 030104 developmental biology, medicine.anatomical_structure, Ultrasonic Waves, Preclinical research, Blood-Brain Barrier, Models, Animal, Medicine, business, Neuroscience, Biomedical engineering, 030217 neurology & neurosurgery, Biomarkers
Abstract

An emerging approach with potential in improving the treatment of neurodegenerative diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain barrier (BBB) in a non-invasive and localized manner. A large body of pre-clinical work has paved the way for the gradual clinical implementation of FUS-induced BBB opening. Even though the safety profile of FUS treatments in rodents has been extensively studied, the histological and behavioral effects of clinically relevant BBB opening in large animals are relatively understudied. Here, we examine the histological and behavioral safety profile following localized BBB opening in non-human primates (NHPs), using a neuronavigation-guided clinical system prototype. We show that FUS treatment triggers a short-lived immune response within the targeted region without exacerbating the touch accuracy or reaction time in visual-motor cognitive tasks. Our experiments were designed using a multiple-case-study approach, in order to maximize the acquired data and support translation of the FUS system into human studies. Four NHPs underwent a single session of FUS-mediated BBB opening in the prefrontal cortex. Two NHPs were treated bilaterally at different pressures, sacrificed on day 2 and 18 post-FUS, respectively, and their brains were histologically processed. In separate experiments, two NHPs that were earlier trained in a behavioral task were exposed to FUS unilaterally, and their performance was tracked for at least 3 weeks after BBB opening. An increased microglia density around blood vessels was detected on day 2, but was resolved by day 18. We also detected signs of enhanced immature neuron presence within areas that underwent BBB opening, compared to regions with an intact BBB, confirming previous rodent studies. Logistic regression analysis showed that the NHP cognitive performance did not deteriorate following BBB opening. These preliminary results demonstrate that neuronavigation-guided FUS with a single-element transducer is a non-invasive method capable of reversibly opening the BBB, without substantial histological or behavioral impact in an animal model closely resembling humans. Future work should confirm the observations of this multiple-case-study work across animals, species and tasks.

Published
2021

20. Blood pressure in children with renal cysts and diabetes syndrome

Author

Filip Fencl, Ulrike John-Kroegel, Veit Grote, Tomáš Seeman, Richard Klaus, Bärbel Lange-Sperandio, Kveta Blahova, Stepanka Pruhova, Katharina Hermes, and Friederike Weigel

Subjects
Cystic kidney, medicine.medical_specialty, Ambulatory blood pressure, Proteinuria, business.industry, Renal function, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Blood pressure, 030225 pediatrics, Internal medicine, Diabetes mellitus, Pediatrics, Perinatology and Child Health, Polycystic kidney disease, Albuminuria, Medicine, 030212 general & internal medicine, medicine.symptom, business
Abstract

Cystic kidney diseases such as autosomal recessive or dominant polycystic kidney disease (ARPKD and ADPKD) are associated with high prevalence of arterial hypertension. On the contrary, studies on hypertension in children with renal cysts and diabetes (RCAD) syndrome caused by abnormalities in the HNF1B gene are rare. Therefore, the primary aim of our study was to investigate the prevalence of high blood pressure in children with RCAD syndrome due to HNF1B gene abnormalities and secondary to search for possible risk factors for development of high blood pressure. Data on all children with genetically proven RCAD syndrome from three pediatric nephrology tertiary centers were retrospectively reviewed (office blood pressure (BP), ambulatory blood pressure monitoring (ABPM), creatinine clearance, renal ultrasound, echocardiography, albuminuria/proteinuria). High blood pressure was defined as BP ≥ 95th percentile of the current ESH 2016 guidelines and/or by the use of antihypertensive drugs. Thirty-two children with RCAD syndrome were investigated. Three children received ACE inhibitors for hypertension and/or proteinuria. High blood pressure was diagnosed using office BP in 22% of the children (n = 7). In the 7 performed ABPM, 1 child (14%) was diagnosed with hypertension and one child with white-coat hypertension. Creatinine clearance, proteinuria, albuminuria, body mass index, enlargement, or hypodysplasia of the kidneys and prevalence of HNF1B-gene deletion or mutation were not significantly different between hypertensive and normotensive children. Conclusion: High blood pressure is present in 22% of children with RCAD syndrome.

Published
2021
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21. Employee competence development in corporate volunteering

Author

Akram Hatami, Jan Hermes, Aldona Glińska-Neweś, Pauliina Ulkuniemi, and Anne Keränen

Subjects
Sustainable development, business.industry, media_common.quotation_subject, 05 social sciences, Beneficiary, Public relations, General Business, Management and Accounting, Empirical research, Perception, 0502 economics and business, Corporate social responsibility, 050211 marketing, Business case, business, Psychology, Competence (human resources), 050203 business & management, Social Sciences (miscellaneous), Diversity (business), media_common
Abstract

PurposeThe purpose of this study is to examine how employee competences can be developed through corporate volunteering (CV). Specifically, this study focuses on diversity of volunteering studies categorized according to the type of beneficiaries and intensity of volunteer contact with them. The study examines how the beneficiary-employee relation influences the development of employee competences in CV projects.Design/methodology/approachIn this qualitative empirical study, interview data collected in Poland about the perceived effects of CV projects on employee competences was used.FindingsThe findings suggest that to understand the competences generated in CV, attention needs to be paid to the nature of the volunteering study itself. The study proposes four different logics of competence development in CV, based on the type of the beneficiary and contact with them.Research limitations/implicationsThe study builds on managers’ perceptions of competence development. For a holistic understanding, future research should include employees’ perceptions of the process. Also, more research is needed regarding national and organizational settings as factors in competence development through CV.Practical implicationsThe study suggests how companies could best engage in volunteering programs and improve existing ones to make them more beneficial for all parties involved.Social implicationsThe findings build the better business case for CV and other corporate social responsibility (CSR) initiatives, i.e. they deliver rationales for business engagement in this regard.Originality/valueThe study contributes to the conceptual understanding of CSR activities by presenting four logics of competence development in CV.

Published
2021
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22. Reduced esophageal heating in high‐power short‐duration atrial fibrillation ablation in the contact force catheter era

Author

Carlos Volponi Lovatto, Christiano Cunha, Aloyr Gonçalves Simoes Jr., Eduardo Serpa, Dalton Amaral, Fabricio Vassallo, Hermes Carloni, and Lucas Luis Meigre

Subjects
Male, medicine.medical_specialty, Hot Temperature, Time Factors, medicine.medical_treatment, Catheter ablation, 030204 cardiovascular system & hematology, Cardioversion, 03 medical and health sciences, Esophagus, 0302 clinical medicine, Internal medicine, Atrial Fibrillation, medicine, Humans, Sinus rhythm, 030212 general & internal medicine, Retrospective Studies, Fibrillation, business.industry, Atrial fibrillation, General Medicine, Middle Aged, medicine.disease, Ablation, Catheter Ablation, Cardiology, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Complication, Atrial flutter
Abstract

BACKGROUND Atrial fibrillation (AF) ablation is alternative treatment to medical therapy. Most feared complication is atrioesophageal fistula METHODS: Observational, retrospective analysis of consecutive 355 patients undergoing first AF ablation. Low-power long-duration (LPLD) group contained 158 patients, with 121 (76.58%) having paroxysmal AF who underwent ablation with power 20/30W (anterior and posterior left atrial wall), 17 mL/min flow, and a contact force of 10-30 g for 30 s. High-power short-duration group (HPSD) contained 197 patients, with 113 (57.36%) having paroxysmal AF who underwent ablation at 45/50W of power with a contact force of 8-15 g/10-20 g and a 35 mL/min flow rate for 6-8 s on the anterior and the posterior left atrial wall, respectively. Both groups had pulmonary veins isolated and atrial flutter was ablated when needed. For patients not in sinus rhythm, cardioversion was performed before ablation RESULTS: There were no complications. LPLD group: Left atrial time 118.74 min, total 145.32 min, radiofrequency time 4317.99s, X-ray 13.42 min, and elevation of luminal esophageal temperature (LET) in 132 (84.53%) patients. HPSD group: Left atrial time 72.16 min, total 93.76 min, radiofrequency time 1511.29s, X-ray 7.6 min, and LET elevation in only 75 (38.07%) patients. A markedly higher rate of first-pass isolation was observed in HPSD compared to LPLD, 77.16% versus 13.29%, respectively. Recurrence occurred in 64 (40.50%) and 32 (16.24%) in 28.45 and 22.35 months in LPLD and HPSD patients, respectively. In LPLD, 10 patients were submitted to endoscopy, and one (10%) had mild erythema and in HPSD, 13 performed the endoscopy, with two (15.38%) patients showing mild erythema CONCLUSION: HPSD technique compared to the LPLD technique showed significant reduced radiofrequency and fluoroscopy times, higher rate of first-pass isolation, lower recurrence rate, and esophageal temperature elevation and may also have a protective effect avoiding incidental esophageal injury due to these findings.

Published
2021
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23. Dynamics in oral health‐related factors of Indigenous Australian children: A network analysis of a randomized controlled trial

Author

Pedro Henrique Ribeiro Santiago, Lisa Jamieson, Edgard Michel-Crosato, Maria Gabriela Haye Biazevic, and Gustavo Hermes Soares

Subjects
Gerontology, medicine.medical_specialty, Native Hawaiian or Other Pacific Islander, Oral Health, Dental Caries, Indigenous, law.invention, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Randomized controlled trial, law, Intervention (counseling), Epidemiology, Humans, Medicine, 030212 general & internal medicine, General Dentistry, Partial correlation, Clustering coefficient, business.industry, Australia, Public Health, Environmental and Occupational Health, 030206 dentistry, stomatognathic diseases, Quality of Life, business, Centrality
Abstract

OBJECTIVES Network analysis is an innovative, analytic approach that enables visual representation of variables as nodes and their corresponding statistical associations as edges. It also provides a new way of framing oral health-related questions as complex systems of variables. We aimed to generate networks of oral health variables using epidemiological data of Indigenous children, and to compare network structures of oral health variables among participants who received immediate or delayed delivery of an oral health intervention. METHODS Epidemiological data from 448 mother-child dyads enrolled in a randomized controlled trial of dental caries prevention in South Australia, Australia, were obtained. Networks were estimated with nodes representing study variables and edges representing partial correlation coefficients between variables. Data included dental caries, impact on quality of life, self-rated general health, self-rated oral health, dental service utilization, knowledge of oral health, fatalism and self-efficacy in three time points. Communities of nodes, centrality, clustering coefficient and network stability were estimated. RESULTS The oral health intervention interacted with the network through self-rated general health and knowledge of oral health. Networks depicting groups shortly after receiving the intervention presented higher clustering coefficients and a similar arrangement of nodes. Networks tended to return to a preintervention state. CONCLUSION The intervention resulted in increased connectivity and changes in the structure of communities of variables in both intervention groups. Our findings contribute to elucidating dynamics between variables depicting oral health networks over time.

Published
2021
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24. Calibration and validation of a freight wagon dynamic model in operating conditions based on limited experimental data

Author

C. Bragança, J. Neto, Nuno Pinto, Diogo Ribeiro, Hermes Carvalho, P.A. Montenegro, and Rui Calçada

Subjects
Engineering, Calibration and validation, business.industry, Mechanical Engineering, Experimental data, 020302 automobile design & engineering, Control engineering, 02 engineering and technology, 020303 mechanical engineering & transports, 0203 mechanical engineering, Automotive Engineering, Genetic algorithm, Safety, Risk, Reliability and Quality, business, Dynamic testing
Abstract

This article presents an efficient methodology for the calibration and validation of a numerical model of a freight wagon based on a dynamic test under real operation conditions. The dynamic test t...

Published
2021
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25. Fatigue safety assessment of longitudinal and transverse reinforcements for concrete girder bridge designs

Author

Hermes Carvalho, Anselmo Leal Carneiro, Túlio Nogueira Bittencourt, Enson de Lima Portela, and André Teófilo Beck

Subjects
Structural safety, business.industry, Computer science, Mechanical Engineering, Girder bridge, Ocean Engineering, Building and Construction, Structural engineering, Geotechnical Engineering and Engineering Geology, ESTRUTURAS, Stress (mechanics), Transverse plane, Girder, Probabilistic analysis of algorithms, Safety, Risk, Reliability and Quality, Reinforcement, business, human activities, Reliability (statistics), Civil and Structural Engineering
Abstract

Highway concrete bridges are subjected to fatigue, with stress cycles from the traffic defining the fatigue lives of reinforcement and concrete. Most existing studies on fatigue reliability of brid...

Published
2021
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26. Initial Experience and Results of Combined Treatment for Atrial Fibrillation: Catheter Ablation with High-Power Short Duration Ablation and Left Atrial Appendage Closure

Author

Betina Reseck Walker, Flávia Pezzin, Hermes Carloni, Dalton Amaral, Lucas Luis Meigre, Aloyr Gonçalves Simoes Jr., Renato Giestas Serpa, Fabricio Vassallo, Walter Batista, Christiano Cunha, Carlos Alexandre Lovatto, Karla Loureiro, and Eduardo Serpa

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Catheter ablation, Atrial fibrillation, 030204 cardiovascular system & hematology, medicine.disease, Amiodarone, Surgery, 03 medical and health sciences, Pseudoaneurysm, 0302 clinical medicine, medicine, Sinus rhythm, 030212 general & internal medicine, Thrombus, business, Stroke, Contraindication, medicine.drug
Abstract

Introduction: Long-term freedom from atrial fibrillation (AF) after catheter ablation and, consequently, the potential for stroke reduction remain unpredictable. Recently, left atrial appendage closure (LAAC) became an effective mechanical alternative to oral anticoagulation (OAC) for stroke prevention in AF patients. Objective: This study aims to evaluate the feasibility and safety of combined treatment for AF with catheter ablation (CA) with the high-power short duration technique associated with LAAC in one single procedure. Methods: Patients with non-valvular AF who underwent combined CA and LAAC procedure were included in the retrospective observational study. Between April 2018 and October 2020, 13 patients with AF were included, eight (61,54%) males, eight (61.54%) with persistent AF (PersAF), mean age 68.54 (65–84) years old, mean time from AF diagnosis to treatment 13.08 (3–33) months, mean CHA2VASC2 5.08 (3–7), all patients with coronary or vascular disease, 12 (92.31%) with hypertension, five (38.46%) with left ventricular dysfunction, four (30.77%) prior strokes using OAC and four (30.77%) patients with diabetes. Indications for LAAC included history of contraindication to OAC because of severe bleeding in eight (61.54%), previous stroke in four (30.77%) and two (13.08%) patients with LAA thrombus, despite the use of two different OAC (one associated with bleeding). One patient had a pseudoaneurysm in femoral artery, and two patients died of non-procedure complications after 30 days. At six months, angiotomography showed successful complete sealing of the LAA in seven (77.72%) of nine patients evaluated, and the two patients without it had a leak of less than 2 mm. After mean follow-up of 14 months (five to 33), 10 (90.91%) of the 11 patients were in sinus rhythm. Three (27.27%) patients, one in blanking period, recovered sinus rhythm after amiodarone. No cardioembolic or bleeding events occurred. Conclusion: In this small observational study, we showed the feasibility and safety of the combined therapy with AF catheter ablation with LAAC with a high rate of sinus rhythm and no cardioembolic event.

Published
2021
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27. Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms

Author

Peter M Morgan, Helen C. Fox, Stephanie E. Wemm, Nia Fogelman, Rajita Sinha, Gretchen Hermes, Gustavo A. Angarita, and Verica Milivojevic

Subjects
medicine.medical_specialty, business.industry, Alcohol, Alcohol use disorder, Moderation, medicine.disease, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, chemistry.chemical_compound, 0302 clinical medicine, chemistry, mental disorders, medicine, Prazosin, Psychiatry, business, 030217 neurology & neurosurgery, Disease burden, medicine.drug
Abstract

Objective: Alcohol use disorder (AUD) is a leading cause of global disease burden. Chronic, heavy use increases the likelihood of alcohol withdrawal symptoms and associated secondary outcomes of al...

Published
2021
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28. Einstellung zur Impfung gegen SARS-CoV-2

Author

Uwe Janssens, Bernd Salzberger, Christian Karagiannidis, Carsten Hermes, Gernot Marx, and Stefan Kluge

Subjects
Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, Emergency Medicine, Internal Medicine, medicine, 030212 general & internal medicine, Emergency Nursing, Critical Care and Intensive Care Medicine, business
Published
2021
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29. Contribution of food groups to energy, grams and nutrients-to-limit: the Latin American Study of Nutrition and Health/Estudio Latino Americano de Nutrición y Salud (ELANS)

Author

Agatha Nogueira Previdelli, Cristiane Hermes Sales, Aline Veroneze de Mello, Irina Kovalskys, Angela Graciela Martinez, Martha Cecilia Yépez García, Ana Carolina B Leme, Mauro Fisberg, Regina Mara Fisberg, Gervasio Gomez, Rossina G. Torres, Marianella Herrera-Cuenca, Lilia Yadira Cortés Sanabria, and Attilio Rigotti

Subjects
Adult, Latin Americans, Adolescent, Population, Medicine (miscellaneous), Biology, Toxicology, Food group, Young Adult, Nutrient, AMÉRICA LATINA, Vegetables, Food classification, Humans, Sugar, education, Aged, Gram, education.field_of_study, Nutrition and Dietetics, business.industry, Public Health, Environmental and Occupational Health, Hispanic or Latino, Nutrients, Middle Aged, Nutrition Surveys, United States, Diet, Cross-Sectional Studies, Latin America, Agriculture, Energy Intake, business, Research Paper
Abstract

Objective:To quantify the energy, nutrients-to-limit and total gram amount consumed and identify their top food sources consumed by Latin Americans.Design:Data from the Latin American Study of Nutrition and Health (ELANS).Setting:ELANS is a cross-sectional study representative of eight Latin American countries: Argentina, Brazil, Chile, Colombia, Costa Rica, Ecuador, Peru and Venezuela.Participants:Two 24-h dietary recalls on non-consecutive days were used to estimate usual dietary intake of 9218 participants with ages between 15–65 years. ‘What We Eat in America’ food classification system developed by United States Department of Agriculture was adapted and used to classify all food items consumed by the ELANS population. Food sources of energy, added sugars, SFA, Na and total gram amount consumed were identified and ranked based on percentage of contribution to intake of total amount.Results:Three-highest ranked food categories of total energy consumed were: rice (10·3%), yeast breads (6·9%), and turnovers and other grain-based items (6·8 %). Highest ranked food sources of total gram amount consumed were fruit drinks (9·6%), other 100% juice (9·3%) and rice (8·3%). Three highest ranked sources for added sugars were other 100% juice (24·1 %), fruit drinks (16·5%), and sugar and honey (12·4%). SFA ranked foods were turnovers and other grain-based (12·6 %), cheese (11·9%), and pizza (10·3%). Three top sources of Na were rice (13·9%), soups (9·1 %) and rice mixed dishes (7·3 %).Conclusion:Identification of top sources of energy and nutrients-to-limit among Latin Americans is critical for designing strategies to help them meet nutrient recommendations within energy needs.

Published
2021
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30. Relational attractiveness between supplier-customer in a supply chain

Author

Rodrigo Soares Santana, Gustavo Hermínio Salati Marcondes de Moraes, Hermes Moretti Ribeiro da Silva, Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp), and Universidade de São Paulo (USP)

Subjects
Value (ethics), Attractiveness, business.industry, Supply chain, 05 social sciences, Context (language use), Customer relationship management, General Business, Management and Accounting, Cooperativism, Confirmatory factor analysis, Structural equation modeling, Education, B2B relationship, Microeconomics, Relationship marketing, Brazil, Relationship marketing, B2B relationship, Cooperativism, Relational attractiveness, 0502 economics and business, 050211 marketing, Business, Relational attractiveness, Brazil, 050203 business & management
Abstract

Purpose This study aims to evaluate the influence of factors attributed to relationship attractiveness between supplier and customer, from the supplier’s perspective. Design/methodology/approach The empirical exercise was based on the use of multivariate data analysis with confirmatory factor analysis and a partial least squares approach to structural equation modeling. Findings The study resulted in a robust model, with a high explanatory factor for the latent variable relational attractiveness and commitment was the most influential factor, followed by expected value and interorganizational trust. Research limitations/implications Some limitations of the study can be highlighted: conducting research in a single cooperative and with a single audience; choosing a short-cycle supply chain, which may make it difficult to generalize to other industries; the cross-section nature of data also hinders the analysis to understand how the association between variables of interest may vary over time. Practical implications The negative influence of interpersonal trust reinforces the importance of developing collaborative attitudes between parties, whereas the non-significant value for dependence (financial and volume dependence) shows this is not a risk factor for relational attractiveness in a supply chain. Such results provide evidence on how to develop relationship management between suppliers and customers that are part of the same supply chain. Social implications It offers a new perspective for research in cooperatives, which still have no consensus on the motivating factors for members’ participation, including as evidence the results of the largest flower producing center in Latin America. The more a cooperative succeeds in increasing relational attractiveness, the greater the cooperative power and the ability to adapt to shocks and changes, which are fundamental factors for the success and longevity of the cooperative. Originality/value The research presents a model that is comprehensive enough to fit in different contexts and consider its specific characteristics. Additionally, this paper has added in-depth information on the relational attractiveness relationships in the context of a developing country.

Published
2021
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31. Displacement Imaging During Focused Ultrasound Median Nerve Modulation: A Preliminary Study in Human Pain Sensation Mitigation

Author

Elisa E. Konofagou, Hermes A. S. Kamimura, and Stephen A. Lee

Subjects
Acoustics and Ultrasonics, business.industry, Transducers, Ultrasound, Sensation, Pain, Pain sensation, Article, Neuromodulation (medicine), Median nerve, Focused ultrasound, Median Nerve, Modulation, Humans, Medicine, Displacement (orthopedic surgery), Electrical and Electronic Engineering, business, Instrumentation, Temporal information, Ultrasonography, Biomedical engineering
Abstract

Focused ultrasound (FUS)-based viscoelastic imaging techniques using high frame rate (HFR) ultrasound to track tissue displacement can be used for mechanistic monitoring of FUS neuromodulation. However, a majority of techniques avoid imaging during the active push transmit (interleaved or postpush acquisitions) to mitigate ultrasound interference, which leads to missing temporal information of ultrasound effects when FUS is being applied. Furthermore, critical for clinical translation, use of both axial steering and real-time (1 s) capabilities for optimizing acoustic parameters for tissue engagement are largely missing. In this study, we describe a method of noninterleaved, single Vantage imaging displacement within an active FUS push with simultaneous axial steering and real-time capabilities using a single ultrasound acquisition machine. Results show that the pulse sequence can track micron-sized displacements using frame rates determined by the calculated time-of-flight (TOF), without interleaving the FUS pulses and imaging acquisition. Decimation by 3-7 frames increases signal-to-noise ratio (SNR) by 15.09±7.03 dB. Benchmarking tests of CUDA-optimized code show increase in processing speed of 35- and 300-fold in comparison with MATLAB parallel processing GPU and CPU functions, respectively, and we can estimate displacement from steered push beams ±10 mm from the geometric focus. Preliminary validation of displacement imaging in humans shows that the same driving pressures led to variable nerve engagement, demonstrating important feedback to improve transducer coupling, FUS incident angle, and targeting. Regarding the use of our technique for neuromodulation, we found that FUS altered thermal perception of thermal pain by 0.9643 units of pain ratings in a single trial. Additionally, 5 [Formula: see text] of nerve displacement was shown in on-target versus off-target sonications. The initial feasibility in healthy volunteers warrants further study for potential clinical translation of FUS for pain suppression.

Published
2021
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32. Incidência de KPC (Klebsiella Pneumoniae Carbapenemase) em adultos internados em hospitais nas regiões do Brasil de 2006 a 2016: revisão bibliográfica

Author

Diana Rodrigues Nicoletti, Morgana Thais Carollo Fernandes, Tássia Vieira Goularte Marçal, Letí­cia Falkenbach da Costa, Bruna Amorin, and Djuli Hermes

Subjects
SciELO, medicine.medical_specialty, biology, Klebsiella pneumoniae, business.industry, Materials Science (miscellaneous), Incidence (epidemiology), MEDLINE, biology.organism_classification, chemistry.chemical_compound, chemistry, Internal medicine, Medicine, business, Ertapenem
Abstract

A Klebsiella pneumoniae carbapenemase (KPC), conhecida como "superbactéria", desempenha um papel importante em relação í s infecções hospitalares. Objetivos: Identificar a incidência de Klebsiella pneumoniae com fator de resistência KPC em adultos nos hospitais das regiões Centro-Oeste, Sudeste e Sul do Brasil entre os anos de 2006 e 2016, observando também, o perfil de resistência aos antimicrobianos. Método: Pesquisa retrospectiva com base descritiva e qualitativa, sendo uma revisão bibliográfica literária sistemática realizada por meio das bases de dados: SciELO, Medline, LILACS e Pubmed. Resultados: Localizou-se 95 artigos, dos quais 58 foram incluí­dos. A região Sul obteve a maior prevalência para isolados KPC nos hospitais, sendo a Klebsiella pneumoniae. Em relação aos antimicrobianos o Ertapenem teve quase 100% de resistência em todos os estados. Conclusão: É necessário que sejam implementadas precauções e o controle da disseminação desse tipo de mecanismo de resistência.

Published
2021
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33. Efecto de un programa de entrenamiento físico en la ocurrencia de arritmias inducidas por el ejercicio en pacientes con cardiopatía

Author

Nayelí García, Karla Castolo Sánchez, María Dolores Ríus Suárez, Angel Avila Estrada, Jessica Espinoza Perez, Jessica Rojano Castillo, Mariana García Saldivia, and Hermes Illaraza Lomelí

Subjects
medicine.medical_specialty, arritmias, Medicine (General), Rehabilitation, Heart disease, rehabilitación cardiaca, RD1-811, business.industry, medicine.medical_treatment, General Medicine, medicine.disease, R5-920, Cardiopulmonary exercise test, Internal medicine, Cohort, Medicine, In patient, Surgery, ejercicio, business, Training program, prueba cardiopulmonar
Abstract

Objetivo. El entrenamiento físico se ha asociado a un incremento en la supervivencia de pacientes cardiopatas, sin embargo, su papel en la disminución de las arritmias inducidas por ejercicio (AIE) en esta población aún no ha sido demostrado. El objetivo del estudio fue evaluar el efecto del entrenamiento físico en la ocurrencia de AIE en pacientes con cardiopatía. Metodología. Se evaluó una cohorte retroprospectiva y autocontrolada de pacientes mayores de 18 años con cardiopatía, que ingresaron al programa de rehabilitación cardíaca del Instituto Nacional de Cardiología Ignacio Chávez de México durante enero del 2005 a diciembre 2016. En todos los pacientes se estratificó el riesgo cardiovascular, incluyendo una prueba de ejercicio cardiopulmonar al inicio y al finalizar el programa. Se evaluó la ocurrencia de arritmias antes y después del programa de entrenamiento. Resultados. Se analizaron 160 pacientes, de los cuales 126 (79%) fueron varones. La proporción de pacientes que desarrollaron AIE en la primera prueba de ejercicio fue de 56% y en la segunda de 48%. Del primer grupo 35% ( n=31) no hizo arritmia en la segunda prueba. De los 71 pacientes que no presentaron AIE al inicio del programa, veinte (28%) las presentaron en la segunda prueba, asociado con un incremento del porcentaje de la frecuencia cardiaca máxima alcanzado. En relación con el efecto del programa de entrenamiento en la ocurrencia de arritmias, pudimos observar que tuvo un efecto protector, con un RR= 0.49 (IC 95%:0.35- 0.67, p

Published
2021

34. Krebserkrankung und das letzte Lebensjahr: Palliative Leistungen, Krankenhausaufenthalte und Sterbeort

Author

Ingrid Schubert, Walter Baumann, Peter Ihle, Kerstin Hermes-Moll, Katja Blaschke, and Veronika Lappe

Subjects
Gynecology, medicine.medical_specialty, Palliative care, business.industry, Public Health, Environmental and Occupational Health, Neoplasms therapy, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Oncology, Place of death, 030220 oncology & carcinogenesis, Claims data, Terminal care, medicine, 030212 general & internal medicine, business
Abstract

Zusammenfassung Einleitung Palliativ versorgte Patientinnen und Patienten haben zu einem hohen Anteil onkologische Diagnosen. Die spezialisierte ambulante Palliativversorgung (SAPV) richtet sich an Erkrankte mit komplexem Symptomgeschehen und intensivem Betreuungsbedarf und soll eine Betreuung im häuslichen Umfeld bis zum Lebensende ermöglichen. In Hessen wurden ab 2009 die ersten SAPV-Angebote geschaffen. Entsprechend untersucht diese Studie (i) die Inanspruchnahme von SAPV und spezialisierten stationären palliativen Leistungen im letzten Lebensjahr von Krebserkrankten, (ii) die SAPV verordnende Arztgruppe und (iii) den Sterbeort und Krankenhausaufenthalte in den letzten 91 Lebenstagen. Methoden In der retrospektiven Sekundärdatenanalyse wurden Daten der AOK Hessen für 2009–2014 deskriptiv ausgewertet. Studienpopulation waren an Brust-, Prostata- oder Darmkrebs Erkrankte, die im jeweiligen Beobachtungsjahr (2010–2014) verstarben und 360 Tage vor ihrem Tod durchgängig versichert waren. Ergebnisse In die Studie konnten je nach Beobachtungsjahr 492–545 Personen mit Brust-, 546–625 mit Prostata- und 709–752 mit Darmkrebs eingeschlossen werden. In allen 3 Gruppen Krebserkrankter stieg zwischen 2010 und 2014 der Anteil mit Inanspruchnahme von mindestens einer Palliativleistung. Die Häufigkeit der Inanspruchnahme von SAPV-Leistungen lag bei den betrachteten Krebserkrankten meist höher im Vergleich zu Palliativstationen bzw. stationären Hospizen. SAPV wurde bei den 3 Krebsdiagnosen zu über 90 % von Hausärztinnen bzw. -ärzten verordnet. Sowohl der Anteil von Personen mit einem Krankenhausaufenthalt in den letzten 91 Lebenstagen als auch der im Krankenhaus Verstorbenen ging von 2010 bis 2014 bei allen 3 Krebsarten zurück. Schlussfolgerung Die Ergebnisse sind vor dem Hintergrund des Aufbaus der SAPV in Hessen zu bewerten. Die Zunahme an SAPV-Leistungen und der Rückgang an Krankenhauseinweisungen am Lebensende weist auf eine gelungene Etablierung der SAPV in Hessen hin.

Published
2021
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35. Extracorporeal life support as bridge to recovery in yew poisoning: case reports and literature review

Author

Daniel Müller, Aline Herzog, Martin Meyer, Judith Engeler, Julia Hermes-Laufer, Hugo Kupferschmidt, Alain Rudiger, Dagmar I. Keller, Dominique Bettex, Bernard Krüger, Julian Henze, Kai Enselmann, University of Zurich, and Krüger, Bernard

Subjects
Adult, Resuscitation, endocrine system, lcsh:Diseases of the circulatory (Cardiovascular) system, Refractory ventricular tachycardia, 10216 Institute of Anesthesiology, Short Communication, Short Communications, Shock, Cardiogenic, 610 Medicine & health, 030204 cardiovascular system & hematology, Ventricular tachycardia, 2705 Cardiology and Cardiovascular Medicine, Extracorporeal, 03 medical and health sciences, Taxus baccata, Extracorporeal Membrane Oxygenation, 0302 clinical medicine, medicine, Humans, 030212 general & internal medicine, ECLS, Cardiogenic shock, 10038 Institute of Clinical Chemistry, Plant Poisoning, business.industry, Arrhythmias, Cardiac, Middle Aged, medicine.disease, Yew poisoning, Treatment Outcome, lcsh:RC666-701, Heart failure, Life support, Anesthesia, 10209 Clinic for Cardiology, Female, Poisoning case, 10023 Institute of Intensive Care Medicine, Differential diagnosis, Cardiology and Cardiovascular Medicine, business
Abstract

Aims This short communication aims to review the treatment of cardiogenic shock in patients with yew poisoning based on two case reports from our institution, focusing on the use of extracorporeal life support (ECLS). Methods and results We report two cases of Taxus baccata poisoning treated with ECLS at our institution and review the literature based on a search in PubMed and Google Scholar on the topic of yew poisoning and ECLS. All cases were combined for analysis of demographics, ECLS therapy, and outcome. Case 1: A 35‐year‐old woman developed polymorphic ventricular tachycardia followed by cardiovascular arrest 5 h after orally ingesting a handful of yew needles. Successful resuscitation required ECLS for 72 h due to ongoing cardiac arrhythmias and cardiogenic shock. The patient left the hospital without neurological sequelae after 10 days. Case 2: A 30‐year‐old woman developed refractory cardiac arrhythmias and circulatory arrest. Resuscitation included ECLS for 71 h. T. baccata needles found by gastroscopy confirmed the diagnosis. The patient had no neurologic deficits and was transferred to psychiatry after 11 days. Review of the literature: Nine case reports were found and analysed along with our two cases. Five out of the 11 (45%) patients were female. Median (range) age was 28 (19–46) years. T. baccata needles were ingested with a suicidal intention in all patients. Median (range) duration of ECLS was 70 h (24–120 h). Eight (73%) patients had full neurological recovery. Conclusions Yew poisoning is a differential diagnosis in young psychiatric patients presenting with polymorphic ventricular tachycardia and cardiogenic shock. A characteristic cardiac contraction pattern in echocardiography may present a diagnostic clue. The early use of ECLS is a valuable bridge to recovery in most of these patients.

Published
2021

36. Evidence of Dental Lamina Preservation in the Development of Mice First Molars

Author

Hermes Pretel, Sebastião Hetem, Celina Antônio Prata, Marlei Seccani Galassi, and Lizeti Toledo Oliveira Ramalho

Subjects
Molar, business.industry, Offspring, Developing tooth, H&E stain, Dentistry, Mandibular first molar, Dental lamina, stomatognathic diseases, stomatognathic system, Dental eruption, Oral epithelium, Medicine, business
Abstract

The aim of this work was to analyse the behaviour of the dental lamina during the development process of first molar teeth. The offspring of female mice were analysed at the 16th day of intra-uterine life and since birth till 17 days old with the aim to evaluate the dental lamina evolution of upper and lower first molars. The animals were sacrificed, and the heads embedded in paraffin in order to get frontal or sagittal sections whose were stained by hematoxylin and eosin method. The results showed a very clear presence of the dental lamina in all periods under analysis, without the occurrence of its disorganization, in other words, it was permanently connecting the developing tooth germ to the oral epithelium until advanced dental eruption.

Published
2021
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37. Value creation in company–NGO collaboration in corporate volunteering

Author

Iwona Escher, Pauliina Ulkuniemi, Paweł Brzustewicz, and Jan Hermes

Subjects
Marketing, Value (ethics), Sustainable development, Value creation, business.industry, 05 social sciences, Public relations, 0502 economics and business, 050211 marketing, Business, Business and International Management, Social responsibility, 050203 business & management, Volunteer work
Abstract

Purpose This paper aims to examine corporate volunteering as a form of social responsibility carried out by companies in relationships with non-governmental organizations (NGOs). Applying the value creation concept, the success of such relationships is based on value created between the focal company, its employees engaging in the volunteer work and the collaborating NGO actors representing the beneficiaries of the volunteer work. However, how to meaningfully engage employees and strategically manage company–NGO relationships in corporate volunteering has received less scholarly attention. The study hence asks the question: How is mutual value created in corporate volunteering collaborations between business organizations and NGOs? Design/methodology/approach Two qualitative case studies of company–NGO relationships involved in corporate volunteer programs for social benefit in Poland and Finland are analyzed. Findings Corporate volunteering offers value creation opportunities for each of the three actors in the relationships, namely, the company, the NGO and the employees who participate in the volunteer work. Particularly, employment and volunteering relationships appear to be catalysts for the creation of mutual value in the organizational relationship between a company and NGO. Originality/value The present study contributes to the current understanding of company–NGO relationships by emphasizing the role of individual employee volunteers in creating relationship-level value. The study adds also to existing research on corporate volunteering by identifying the way value is created in company–NGO relationships within corporate volunteering.

Published
2021
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38. Association of Intensive Lifestyle and Metformin Interventions With Frailty in the Diabetes Prevention Program Outcomes Study

Author

Jill P. Crandall, Andrea M. Kriska, Sherita Hill Golden, Hermes Florez, Helen P. Hazuda, José A. Luchsinger, Qing Pan, Elizabeth M. Venditti, and George A. Bray

Subjects
Male, Aging, medicine.medical_specialty, THE JOURNAL OF GERONTOLOGY: Medical Sciences, 030209 endocrinology & metabolism, Placebo, Gee, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Humans, Hypoglycemic Agents, Medicine, 030212 general & internal medicine, Prediabetes, Life Style, Frailty, business.industry, Repeated measures design, Odds ratio, Middle Aged, medicine.disease, Metformin, Clinical trial, Diabetes Mellitus, Type 2, Female, Geriatrics and Gerontology, business, Follow-Up Studies, medicine.drug
Abstract

Background Frailty is a geriatric syndrome of decreased physiologic reserve and resistance to stressors that results in increased vulnerability to adverse health outcomes with aging. Diabetes and hyperglycemia are established risk factors for frailty. We sought to examine whether the odds of frailty among individuals at high risk of diabetes randomized to treatment with intensive lifestyle (ILS), metformin, or placebo differed after long-term follow-up. Method The sample comprised participants in the Diabetes Prevention Program (DPP) clinical trial, who continued follow-up in the DPP Outcomes Study (DPPOS) and completed frailty assessments in DPPOS Years 8 (n = 2385) and 10 (n = 2289), approximately 12 and 14 years after DPP randomization. Frailty was classified using Fried Frailty Phenotype criteria. GEE models adjusting for visit year with repeated measures pooled for Years 8 and 10 were used to estimate pairwise odds ratios (ORs) between ILS, metformin, and placebo for the outcomes of frail and prefrail versus nonfrail. Results Frailty prevalence by treatment group was ILS = 3.0%, metformin = 5.4%, placebo = 5.7% at Year 8, and ILS = 3.6%, metformin = 5.3%, placebo = 5.4% at Year 10. Odds ratios (95% CI) estimated with GEE models were ILS versus placebo, 0.62 (0.42–0.93), p = .022; metformin versus placebo, 0.99 (0.69–1.42), p = .976; and ILS versus metformin, 0.63 (0.42–0.94), p = .022. Odds of being frail versus nonfrail were 37% lower for ILS compared to metformin and placebo. Conclusions Early ILS intervention, at an average age of about 50 years, in persons at high risk of diabetes may reduce frailty prevalence in later life. Metformin may be ineffective in reducing frailty prevalence. Clinical Trials Registration Numbers NCT00004992 (DPP) and NCT00038727 (DPPOS).

Published
2021
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39. Curriculum Internistische Intensivmedizin

Author

Valentin Fuhrmann, H.-J. Busch, Stefan Kluge, Konstantin Mayer, Pia Lebiedz, Michael Buerke, F. Sayk, Matthias Kochanek, Carsten Hermes, Frank Erbguth, Christian Karagiannidis, S. John, Uwe Janssens, Karl Werdan, Ursula Müller-Werdan, Michael Oppert, Daniel Sedding, Stephan Braune, Guido Michels, Reimer Riessen, M. Baumgärtel, and Carsten Willam

Subjects
Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, Emergency Medicine, Internal Medicine, medicine, 030212 general & internal medicine, Emergency Nursing, Critical Care and Intensive Care Medicine, business
Abstract

Die Internistische Intensivmedizin ist fur die intensivmedizinische Diagnostik, Uberwachung, Therapie, Pflege und Nachsorge von Patienten mit schweren, potenziell lebensbedrohlichen Erkrankungen aus dem gesamten Bereich der Inneren Medizin verantwortlich. Die Qualifikation in Internistischer Intensivmedizin erfordert breite Kenntnisse und praktische Fahigkeiten, zum einen im gesamten Fach Innere Medizin und zum anderen in der konservativen (Internistischen) Intensivmedizin einschlieslich der Einbeziehung spezieller Diagnostik- und Therapieoptionen der angrenzenden Fachgebiete. Die Patientenbetreuung darf sich deshalb nicht nur auf lebenserhaltende Masnahmen beschranken, sondern muss wahrend der intensivmedizinischen Behandlungsphase auch die zugrunde liegenden internistischen Erkrankungen in bestmoglicher Weise einschliesen. Das Fundament der Internistischen Intensivmedizin beinhaltet theoretische Kenntnisse, praktische Fahigkeiten (Kompetenzlevel I–III) und eine adaquate beruflich-professionelle Einstellung. Fur die Zusatz-Weiterbildung (ZWB) (Internistische) Intensivmedizin der Bundesarztekammer soll dieses Curriculum der Deutschen Gesellschaft fur Internistische Intensivmedizin und Notfallmedizin (DGIIN) dem intensivmedizinisch weiterzubildenden Internisten die Moglichkeit geben, seine Weiterbildungszeit so effizient wie moglich zu strukturieren, sich gut auf die Prufung vorzubereiten und das Erlernte anschliesend im Sinne eines „berufslebenslangen“ Qualifizierens zu bewahren. Das Curriculum mochte aber auch die Weiterbilder und Weiterbildungsausschusse der Arztekammern erreichen und aufzeigen, welche Kenntnisse und Fertigkeiten nach Ansicht der DGIIN in der ZWB zum Internistischen Intensivmediziner vermittelt werden sollen.

Published
2021
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40. Quantitative Analysis of β-Asarone Derivatives in Acorus calamus and Herbal Food Products by HPLC-MS/MS

Author

Benedikt Cramer, Melanie Esselen, Lena Hermes, and Janis Römermann

Subjects
biology, Traditional medicine, Chemistry, business.industry, General Chemistry, biology.organism_classification, chemistry.chemical_compound, Hplc ms ms, Food products, Toxicity, Acorus calamus, Food processing, Asarone, General Agricultural and Biological Sciences, business, Quantitative analysis (chemistry), Drug metabolism
Abstract

α-Asarone and β-asarone are reported as bioactive constituents of Acorus calamus. Phase I metabolism of asarone isomers results in a multiple spectrum of genotoxic metabolites. Thus, the question arises whether structural analogues of the known phase I metabolites also naturally occur in A. calamus-based food products. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for three product classes, herbal infusions, alcoholic beverages, and food supplements. High asarone contents were detected in herbal infusions (total mean 9.13 mg/kg, n = 8) and food supplements (total mean 14.52 mg/kg, n = 6); hence, these food products can highly contribute to human exposure to genotoxic asarone derivatives. Also, the occurrence of asarone oxidation products found in food and food supplements has to be taken under consideration because data on toxicity is limited so far.

Published
2021
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41. Pain mapping and characteristics in breast cancer survivors during task-oriented training: analysis at 3, 6, and 9 months

Author

Anke Bergmann, Kamilla Zomkowski, Natália de Souza Cunha, Mariana Dos Santos Hermes, Bruna Baungarten Hugen Back, and Fabiana Flores Sperandio

Subjects
Adult, Shoulder, medicine.medical_specialty, Movement, Population, Upper limb pain, Breast Neoplasms, Upper Extremity, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Cancer Survivors, Musculoskeletal Pain, Surveys and Questionnaires, Dash, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, education, Exercise, Pain Measurement, education.field_of_study, business.industry, Middle Aged, medicine.disease, Trunk, Exercise Therapy, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Arm, Physical therapy, Upper limb, Female, Analysis of variance, business
Abstract

To evaluate the frequency and characteristics of trunk and upper limb pain in women diagnosed with breast cancer, in different movement planes, during task-oriented training (TOT) 3, 6, and 9 months after surgery. A prospective cohort study with 20 women. The body pain diagram (BPD), VAS, and McGill questionnaire were used. The TOT consisted of 20 exercises based on the Disabilities of the Arm, Shoulder and Hand Questionnaire (DASH) questionnaire. BPD overlay was performed in GIMP® image editor. The chi-square test was applied to the relationship between population characteristics and pain. Freedman's ANOVA and the Cochran's Q test were used in the comparison of pain site frequencies and intensity over time. In total, 297 BPDs were generated, which identified the affected upper limb as the body area with the highest frequency of pain at the three moments. However, at 9 months, the unaffected upper limb presented the same frequency as the affected limb. Radiotherapy presented a statistically significant relationship (p

Published
2021
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42. Cathelicidin protects mice from Rhabdomyolysis-induced Acute Kidney Injury

Author

Suely Kubo Ariga, Antonio Carlos Seguro, Beatriz Helena Cermaria Soares da Silva, Rildo Aparecido Volpini, Denise Frediani Barbeiro, Fabiano Pinheiro da Silva, and Hermes Vieira Barbeiro

Subjects
Glycerol, Male, antimicrobial peptide, medicine.medical_treatment, Antimicrobial peptides, Inflammation, Context (language use), Kidney, urologic and male genital diseases, Injections, Intramuscular, Rhabdomyolysis, Cathelicidin, sepsis, Sepsis, Mice, 03 medical and health sciences, 0302 clinical medicine, Cathelicidins, cathelicidin, medicine, Animals, Humans, innate immunity, Mice, Knockout, business.industry, Acute kidney injury, General Medicine, Acute Kidney Injury, medicine.disease, Disease Models, Animal, Immunology, lipids (amino acids, peptides, and proteins), 030211 gastroenterology & hepatology, medicine.symptom, business, Antimicrobial Cationic Peptides, Signal Transduction, Research Paper
Abstract

Background: Cathelicidins are ancient and well-conserved antimicrobial peptides (AMPs) with intriguing immunomodulatory properties in both infectious and non-infectious inflammatory diseases. In addition to direct antimicrobial activity, cathelicidins also participate in several signaling pathways inducing both pro-inflammatory and anti-inflammatory effects. Acute kidney injury (AKI) is common in critically ill patients and is associated with high mortality and morbidity. Rhabdomyolysis is a major trigger of AKI. Objectives: Here, we investigated the role of cathelicidins in non-infectious Acute kidney Injury (AKI). Method: Using an experimental model of rhabdomyolysis, we induced AKI in wild-type and cathelicidin-related AMP knockout (CRAMP-/-) mice. Results: We previously demonstrated that CRAMP-/- mice, as opposed wild-type mice, are protected from AKI during sepsis induced by cecal ligation and puncture. Conversely, in the current study, we show that CRAMP-/- mice are more susceptible to the rhabdomyolysis model of AKI. A more in-depth investigation of wild-type and CRAMP-/- mice revealed important differences in the levels of several inflammatory mediators. Conclusion: Cathelicidins can induce a varied and even opposing repertoire of immune-inflammatory responses depending on the subjacent disease and the cellular context.

Published
2021
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44. Spatially assessing unpleasant places with hard- and soft-GIS methods: a river landscape application

Author

Johannes Hermes, Sarah Gottwald, Christian Albert, Stefan Schmidt, and Sina Röing

Subjects
Geographic information system, Ecology, business.industry, christine fürst, media_common.quotation_subject, Environmental resource management, Management, Monitoring, Policy and Law, Research objectives, Environmental sciences, GF1-900, Geography, Human ecology. Anthropogeography, Automotive Engineering, GE1-350, Quality (business), business, Ecology, Evolution, Behavior and Systematics, Nature and Landscape Conservation, media_common
Abstract

This paper explores the visual, acoustic and olfactory impairments to landscape aesthetic quality in a river landscape case study, using hard- and soft-GIS approaches. The research objectives are (1) to develop a model that localizes the spatial distribution of areas likely perceived as unpleasant and assesses the intensity of visual, acoustic and olfactory impairments in those areas by using a hard-GIS method, and (2) to test the statistical validity of the model based on results gained from a soft GIS method. The case study area is the Lahn river landscape, Germany. Results show a substantial share of the study area affected by modelled impairments, especially areas close to urban environments and along rivers. The area affected by impairments is highest for visual (91%), followed by acoustic (84%) and olfactory factors (54%). However, impairment intensities are greatest for acoustics (30% of study area) and visual (18%). Soft-GIS data tests revealed statistical defensibility of modeled impaired areas. The results highlight the importance of disaggregate analyses of impairments and can provide information on suitable locations for interventions to minimize impairments. Combining hard-GIS with soft-GIS methods may contribute to the credibility, relevance and legitimacy of scientific findings for planning processes and decision-making.

Published
2021
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45. Cyberspace as an Example of Self-Organisation from a Network Perspective

Author

Cäcilia Maria Hermes

Subjects
Self organisation, business.industry, Perspective (graphical), Sociology, Public relations, Cyberspace, business
Abstract

The present contribution defends network theory empirically by considering the governance of cyberspace. It aims to normatively explain the largely non-state regulation of cyberspace with the help of network theory. To this end, it first introduces key conglomerates of cyberspace governance and analyses their structures and processes. The empirical analysis of the organisational structures forms the basis for the concluding theoretical evaluation. The contribution can serve as an impulse for further research on global governance in a departure from state-centred perceptions.

Published
2021
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46. Como engajar estudantes das séries iniciais (5º ano) a desenvolver o pensamento matemático utilizando robótica e aprendizagem maker

Author

Sandra Muniz Bozolan and Hermes Renato Hildebrand

Subjects
business.industry, Computer science, Process (engineering), Software tool, Computational thinking, Learning to program, Primary education, Robotics, Artifact (software development), Scratch, Mathematics education, Artificial intelligence, business, computer, computer.programming_language
Abstract

O processo de ensino e aprendizagem dos fundamentos de programação tem se demonstrado difícil e complexo para alunos e professores. Desta forma, torna-se imprescindível desenvolver pesquisas para sua melhoria. Cada vez mais, percebe-se que o aprendizado de programação é um grande desafio para todos os alunos, em diversas áreas do conhecimento. Sendo assim, essa pesquisa busca mostrar como o “pensamento computacional”, aliado a uma ferramenta de software, pode auxiliar no processo de ensino e aprendizagem de alunos do 5º ano do ensino fundamental, que tiveram atividades envolvendo o raciocínio matemático e o uso de ferramentas computacionais. Neste sentido, métodos que facilitam a aprendizagem no ensino fundamental podem ser utilizados de forma eficiente. O presente trabalho propõe três cenários que são exemplos de processos de aprendizagem: desenvolvimento dos conceitos matemáticos de práticas computacionais e desenvolvimento de aprendizado computacional. E os resultados obtidos neste estudo de caso comprovam a eficácia do método aplicado.

Published
2020
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48. Do network centrality measures predict dental outcomes of Indigenous children over time?

Author

Gustavo Hermes Soares, Lisa Jamieson, Maria Gabriela Haye Biazevic, Pedro Henrique Ribeiro Santiago, and Edgard Michel-Crosato

Subjects
Gerontology, media_common.quotation_subject, Closeness, Psychological intervention, Mothers, Oral Health, Dental Caries, Indigenous, Literacy, law.invention, 03 medical and health sciences, 0302 clinical medicine, Betweenness centrality, Randomized controlled trial, Pregnancy, law, Humans, Medicine, 030212 general & internal medicine, Child, Baseline (configuration management), General Dentistry, media_common, business.industry, 030206 dentistry, Health Literacy, stomatognathic diseases, Cross-Sectional Studies, Child, Preschool, Female, Centrality, business
Abstract

Background Centrality measures identify items that are central to a network, which may inform potential targets for oral interventions. Aim We tested whether centrality measures in a cross-sectional network of mothers' baseline factors are able to predict the association with children's dental outcomes at age 5 years. Design A network approach was applied to longitudinal data from a randomised controlled trial of dental caries prevention delivered to 448 women pregnant with an Indigenous child in South Australia. Central items were identified at baseline using three centrality measures (strength, betweenness, and closeness). Centrality values of mothers' outcomes were regressed with their predictive values to dental caries experience and dental service utilisation at child age 5 years. Results Items of oral health self-efficacy and oral health literacy were central to mothers' baseline network. Strength at baseline explained 51% and 45% of items' predictive values to dental caries experience and dental service utilisation at child age 5 years, respectively. Adjusted and unadjusted values of node strength for the children's oral health network were highly correlated. Conclusion Strength at baseline successfully identified mothers' items with greater importance to dental caries experience and dental service utilisation at child age 5 years.

Published
2020
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49. Horizontal muon track identification with neural networks in HAWC

Author

Ian Herzog, Lukas Nellen, Hao Zhou, Ramiro Torres Escobedo, Segev BenZvi, Nicola Omodei, Samridha Kunwar, Arturo Iriarte, Israel Martinez Castellanos, David Kieda, Ke Fang, Hannah Jhee, Josefa Becerra Gonzalez, Harm Schoorlemmer, Jesús Martínez-Castro, Michael Newbold, Francisco Salesa Greus, Fernando Garfias, J. A. Goodman, Joshua Wood, David Berley, Nissim Illich Fraija, Alison Peisker, Thomas Weisgarber, Andrew James Smith, Xiaojie Wang, Henrike Fleischhack, Rishi Babu, Kelly Malone, Jason Fan, Humberto Ibarguen Salazar, Rhiannon Turner, Chad Brisbois, Vikas Joshi, Kristi Engel, Dezhi Huang, Diego Garcia Aguilar, Vincent Marandon, Alberto Carramiñana, Brenda Dingus, Mehr Nisa, Raquel Diaz Hernandez, Ian James Watson, Vardan Baghmanyan, José Roberto Angeles Camacho, Daniel Omar Avila Rojas, Hawc, Miguel Mostafa, Dirk Lennarz, Jorge Luis Flores, Cederik León de León, Ibrahim Torres, Joe Lundeen, Gilgamesh Luis-Raya, Maria Magdalena González, Pedro Miranda-Romagnoli, Kirsten Tollefson, Eucario Gonzalo Pérez Pérez, Andrea Albert, Hugo Alberto Ayala Solares, Eduardo Moreno Barbosa, Roberto Noriega-Papaqui, Eduardo de la Fuente, Gwenael Giacinti, Filiberto Hueyotl-Zahuantitla, Juan Carlos Arteaga Velazquez, Guillermo García-Torales, Arun Babu Kollamparambil, Robert Ellsworth, Meghan Tanner, Gerd J. Kunde, Colas Rivière, Hermes Leon Vargas, Oscar Chaparro-Amaro, Umberto Cotti, Arnulfo Zepeda, Sabrina Casanova, Ruben Lopez-Coto, Brian Fick, Pooja Surajbali, Andrés Sandoval, Lorenzo Diaz, Laura Olivera-Nieto, Yunior Pérez Araujo, Anna Lia Longinotti, Gus Sinnis, Fernando Ureña-Mena, Ernesto Belmont-Moreno, Jim Hinton, María Catalina Espinoza Hernández, Jorge Antonio Morales Soto, Tomás Capistrán, Hazal Goksu, Gaurang Yodh, Sergio Hernández Cadena, Brian Humensky, Jorge Cotzomi, Anushka Udara Abeysekara, Michelle Hui, Elijah Willox, César Alvarez, Jose Luis García-Luna, Ignacio Taboada, José Serna-Franco, Ruben Alfaro, Karen S. Caballero Mora, Jason Lee, J. T. Linnemann, Daniel Rosa-Gonzalez, Michael Schneider, Luis Villaseñor, Felix Werner, Ahron S. Barber, Jose Andres Garcia-Gonzalez, John Matthews, Mora Durocher, Petra Hüntemeyer, Mateo Fernandez Alonso, Oscar Martinez, Wayne Robert Springer, Amid Nayerhoda, James Ryan, Binita Hona, Sara Coutiño de Leon, Alejandro Lara, Michael DuVernois, Juan de Dios Álvarez Romero, William H. Lee, Julie McEnery, Juan Carlos Díaz Vélez, Chang Dong Rho, Armelle Jardin-Blicq, J. Patrick Harding, Humberto Martínez Huerta, Edna Ruiz-Velasco, and HAWC Collaboration

Subjects
HAWC - Abteilung Hinton, Physics - Instrumentation and Detectors, Muon, Artificial neural network, Computer science, business.industry, Track (disk drive), Computer Science::Neural and Evolutionary Computation, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Identification (information), Computer vision, Artificial intelligence, Astrophysics - Instrumentation and Methods for Astrophysics, business, Instrumentation and Methods for Astrophysics (astro-ph.IM)
Abstract

Nowadays the implementation of artificial neural networks in high-energy physics has obtained excellent results on improving signal detection. In this work we propose to use neural networks (NNs) for event discrimination in HAWC. This observatory is a water Cherenkov gamma-ray detector that in recent years has implemented algorithms to identify horizontal muon tracks. However, these algorithms are not very efficient. In this work we describe the implementation of three NNs: two based on image classification and one based on object detection. Using these algorithms we obtain an increase in the number of identified tracks. The results of this study could be used in the future to improve the performance of the Earth-skimming technique for the indirect measurement of neutrinos with HAWC., Comment: 8 pages, 6 figures, Proceedings of the 37th International Cosmic Ray Conference (ICRC 2021)

Published
2022

50. Nature of Cardiac Rehabilitation Around the Globe

Author

Jo Hayward, Masoumeh Sadeghi, Egle Tamuleviciute-Prasciene, Francisco Lopez-Jimenez, Stefan Farsky, Bruno Pavy, Wayne Derman, Attila Simon, Tee Joo Yeo, Eleonora Vataman, Brendon Roxburgh, Anna Kiessling, Dawn C. Scantlebury, Ilker Yagci, Nizal Sarrafzadegan, Marco Ambrosetti, Evangelia Kouidi, Dayi Hu, Dan Gaita, Marta Supervia, Sherry L. Grace, Arto J. Hautala, Juan Castillo Martin, Claudio Santibáñez, Basuni Radi, Randal J. Thomas, Elad Asher, Ella Pesah, Ana Abreu, Graciela Gonzalez, Raquel Rodrigues Britto, Chul Kim, Ssu-Yuan Chen, Abraham Samuel Babu, Birna Bjarnason-Wehrens, Claudia Victoria Anchique Santos, Jacqueline Cliff, Rongjing Ding, Vojislav Giga, Dusko Vulic, Gerard Burdiat, Rosalia Fernandez, Lis Neubeck, Susan Dawkes, Karam Turk-Adawi, Karl Andersen, Cecilia Zeballos, Zbigniew Eysymontt, Lucky Cuenza, Seng K. Jong, Richard Salmon, L Maskhulia, Hermes Lomelí, Eduardo Rivas Estany, Briseida Benaim, Eva Prescott, Eliška Sovová, Hareld M. C. Kemps, Carolyn Baer, Supervia, Marta, Turk-Adawi, Karam, Lopez-Jimenez, Francisco, Pesah, Ella, Ding, Rongjing, Britto, Raquel R., Bjarnason-Wehrens, Birna, Derman, Wayne, Abreu, Ana, Babu, Abraham S., Santos, Claudia Anchique, Jong, Seng K., Cuenza, Lucky, Yeo, Tee Joo, Scantlebury, Dawn, Andersen, Karl, Gonzalez, Graciela, Giga, Vojislav, Vulic, Dusko, Vataman, Eleonora, Cliff, Jacqueline, Kouidi, Evangelia, Yagci, Ilker, Kim, Chul, Benaim, Briseida, Estany, Eduardo Rivas, Fernandez, Rosalia, Radi, Basuni, Gaita, Dan, Simon, Attila, Chen, Ssu-Yuan, Roxburgh, Brendon, Martin, Juan Castillo, Maskhulia, Lela, Burdiat, Gerard, Salmon, Richard, Lomeli, Hermes, Sadeghi, Masoumeh, Sovova, Eliska, Hautala, Arto, Tamuleviciute-Prasciene, Egle, Ambrosetti, Marco, Neubeck, Lis, Asher, Elad, Kemps, Hareld, Eysymontt, Zbigniew, Farsky, Stefan, Hayward, Jo, Prescott, Eva, Dawkes, Susan, Santibanez, Claudio, Zeballos, Cecilia, Pavy, Bruno, Kiessling, Anna, Sarrafzadegan, Nizal, Baer, Carolyn, Thomas, Randal, Hu, Dayi, Grace, Sherry L., Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, and University of Iceland

Subjects
Heilsufar, medicine.medical_treatment, Cardiac rehabilitation, SECONDARY PREVENTION, 01 natural sciences, Coronary artery bypass surgery, 0302 clinical medicine, PROGRAMS, Cardiac rehabilitation, Nature, Preventive cardiology, Global health, Health services, Survey, Global health, Blóðrásarsjúkdómar, 030212 general & internal medicine, Myocardial infarction, Survey, CARDIOLOGY, Response rate (survey), lcsh:R5-920, Rehabilitation, STATEMENT, Preventive cardiology, Saúde - Pesquisa, General Medicine, Health services, AMERICAN-ASSOCIATION, lcsh:Medicine (General), Research Paper, medicine.medical_specialty, Kannanir, Programas de sáude, Endurhæfing, World health, Cardiologia, 03 medical and health sciences, MANAGEMENT, medicine, QUALITY, 0101 mathematics, DELIVERY MODEL, business.industry, AVAILABILITY, Reabilitação cardíaca, 010102 general mathematics, Percutaneous coronary intervention, Guideline, medicine.disease, Nature, CORE COMPONENTS, Family medicine, Coração - Doenças, business
Abstract

Publisher's version (útgefin grein), Background: Cardiac rehabilitation (CR) is a clinically-effective but complex model of care. The purpose of this study was to characterize the nature of CR programs around the world, in relation to guideline recommendations, and compare this by World Health Organization (WHO) region. Methods: In this cross-sectional study, a piloted survey was administered online to CR programs globally. Cardiac associations and local champions facilitated program identification. Quality (benchmark of ≥ 75% of programs in a given country meeting each of 20 indicators) was ranked. Results were compared by WHO region using generalized linear mixed models. Findings: 111/203 (54.7%) countries in the world offer CR; data were collected in 93 (83.8%; N = 1082 surveys, 32.1% program response rate). The most commonly-accepted indications were: myocardial infarction (n = 832, 97.4%), percutaneous coronary intervention (n = 820, 96.1%; 0.10), and coronary artery bypass surgery (n = 817, 95.8%). Most programs were led by physicians (n = 680; 69.1%). The most common CR providers (mean = 5.9 ± 2.8/program) were: nurses (n = 816, 88.1%; low in Africa, p < 0.001), dietitians (n = 739, 80.2%), and physiotherapists (n = 733, 79.3%). The most commonly-offered core components (mean = 8.7 ± 1.9 program) were: initial assessment (n = 939, 98.8%; most commonly for hypertension, tobacco, and physical inactivity), risk factor management (n = 928, 98.2%), patient education (n = 895, 96.9%), and exercise (n = 898, 94.3%; lower in Western Pacific, p < 0.01). All regions met ≥ 16/20 quality indicators, but quality was < 75% for tobacco cessation and return-to-work counseling (lower in Americas, p = < 0.05). Interpretation: This first-ever survey of CR around the globe suggests CR quality is high. However, there is significant regional variation, which could impact patient outcomes., This project was supported by a research grant from York University 's Faculty of Health. The funder had no role in study design, data collection, data analysis, interpretation or writing of the report.

Published
2019
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