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Alves, RR, Viana, RB, Silva, MH, Guimaraes, TC, Vieira, CA, Santos, DdAT, and Gentil, PRV. Postactivation potentiation improves performance in a resistance training session in trained men. J Strength Cond Res XX(X): 000-000, 2019-This study aims to analyze the influence of postactivation potentiation (PAP) on performance during a resistance training (RT) session in trained individuals. Fourteen trained men (25.0 ± 3.5 years; 89.9 ± 16.3 kg; 1.77 ± 0:08 m; 28.0 ± 4.0 kg·m; and 5 ± 4 years of RT experience) were tested in 2 situations: with PAP and without PAP (CON). Both situations involved 3 sets of the bench press exercise performed to muscle failure at 75% of the 1 repetition maximum load and with 1.5-minute interval between sets. Total work was greater (p < 0.001) for PAP (1,601 ± 504 kg) than for CON (1,379 ± 364 kg). The number of repetitions performed in the first and second sets of PAP (11.5 ± 3.1 and 6.5 ± 1.9, respectively) were greater (p < 0.05) than those performed in CON (10.4 ± 2.7, 5.5 ± 1.8, respectively). No significant difference was found in the number of repetitions in the last set between the situations. The present study suggests that PAP might be beneficial to improve total work and performance during multiple sets of RT in trained men. Therefore, PAP might be used during RT to promote higher total work and potentially increase results over long term. Thus, the protocol can use in sports centers, fitness centers, and gyms per coaches and athletes to increase performance and total work in trained individuals.

The aim of this study was to compare two different maximal intensity exercise modality training protocols of similar durations on muscle strength, cardiorespiratory fitness, and lower limb composition in recreationally trained men. Twenty-five trained men (28.9 ± 5.6 years) were randomly divided into Cycle ergometer (4 sets of 30 seconds sprints) and Leg press (4 sets of 10-12 repetitions to momentary failure). Both groups trained three times a week for 5 weeks. Before and after the training period, the participants performed a 10-repetition maximum (10RM) test for knee extension, an incremental exercise test on a treadmill for time to exhaustion (TTE) and peak oxygen consumption (V˙O2peak) and underwent dual energy X-ray absorptiometry to assess lower limb composition. Knee extension 10RM and TTE increased in both groups with no statistically significant between group (p = 0.614 and p = 0.210). Only cycle ergometer group increased V˙O2peak (p= 0,012). For all lower limb composition outcomes, changes were minimal. The results suggest that 5 weeks of effort and duration matched exercise protocols using cycle ergometer training or leg press may produce similar strength adaptations.

Training-intensity distribution (TID) is considered the key factor to optimize performance in endurance sports. This systematic review aimed to: I) characterize the TID typically used by middle-and long-distance runners; II) compare the effect of different types of TID on endurance performance and its physiological determinants; III) determine the extent to which different TID quantification methods can calculate same TID outcomes from a given training program. The keywords and search strategy identified 20 articles in the research databases. These articles demonstrated differences in the quantification of the different training-intensity zones among quantification methods (i. e. session-rating of perceived exertion, heart rate, blood lactate, race pace, and running speed). The studies that used greater volumes of low-intensity training such as those characterized by pyramidal and polarized TID approaches, reported greater improvements in endurance performance than those which used a threshold TID. Thus, it seems that the combination of high-volume at low-intensity (≥ 70% of overall training volume) and low-volume at threshold and high-intensity interval training (≤ 30%) is necessary to optimize endurance training adaptations in middle-and long-distance runners. Moreover, monitoring training via multiple mechanisms that systematically encompasses objective and subjective TID quantification methods can help coaches/researches to make better decisions.

The SARS-CoV-2 virus causes a respiratory disease in humans, known as COVID-19. The confirmatory diagnostic of this disease occurs through the real-time reverse transcription and polymerase chain reaction test (RT-qPCR). However, the period of obtaining the results limits the application of the mass test. Thus, chest X-ray computed tomography (CT) images are analyzed to help diagnose the disease. However, during an outbreak of a disease that causes respiratory problems, radiologists may be overwhelmed with analyzing medical images. In the literature, some studies used feature extraction techniques based on CNNs, with classification models to identify COVID-19 and non-COVID-19. This work compare the performance of applying pre-trained CNNs in conjunction with classification methods based on machine learning algorithms. The main objective is to analyze the impact of the features extracted by CNNs, in the construction of models to classify COVID-19 and non-COVID-19. A SARS-CoV-2 CT data-set is used in experimental tests. The CNNs implemented are visual geometry group (VGG-16 and VGG-19), inception V3 (IV3), and EfficientNet-B0 (EB0). The classification methods were k-nearest neighbor (KNN), support vector machine (SVM), and explainable deep neural networks (xDNN). In the experiments, the best results were obtained by the EfficientNet model used to extract data and the SVM with an RBF kernel. This approach achieved an average performance of 0.9856 in the precision macro, 0.9853 in the sensitivity macro, 0.9853 in the specificity macro, and 0.9853 in the F1 score macro.

Photobiomodulation is a non-pharmacological tool widely used to reduce inflammation in many tissues. However, little is known about its effects on the inflammatory response in the aged brain. We conducted the study to examine anti-inflammatory effects of photobiomodulation in aging brains. We used aged rats (20 months old) with control (handled, laser off) or transcranial laser (660 nm wavelength, 100 mW power) treatments for 10 consecutive days and evaluated the level of inflammatory cytokines and chemokines, and the expression and activation of intracellular signaling proteins in the cerebral cortex and the hippocampus. Inflammatory analysis showed that aged rats submitted to transcranial laser treatment had increased levels of IL-1alpha and decreased levels of IL-5 in the cerebral cortex. In the hippocampus, the laser treatment increased the levels of IL-1alpha and decreased levels of IL-5, IL-18, and fractalkine. Regarding the intracellular signaling proteins, a reduction in the ERK and p38 expression and an increase in the STAT3 and ERK activation were observed in the cerebral cortex of aged rats from the laser group. In addition, the laser treatment increased the hippocampal expression of p70S6K, STAT3, and p38 of aged rats. Taken together, our data indicate that transcranial photobiomodulation can improve the inflammatory response and the activation of intracellular signaling proteins linked to vascular function and cell survival in the aged brain.

Wang et al. [1] publicaram recentemente no Journal of Sports and Heath Science uma revisão intitulada “MicroRNAs in heart and circulation during physical exercise” onde sumarizam o papel regulatório de pequenas moléculas do ácido ribonucleico (RNA) não codificantes, os microRNAs (miRNAs), na fisiopatologia e nas respostas cardiovasculares frente ao exercício físico...

Pain is the most common symptom of osteoarthritis, and spinal glia is known to contribute to this symptom. Therapeutic ultrasound and laser therapy have been used to effectively treat osteoarthritis, with few adverse effects. Thus, this study aimed to investigate the effects of ultrasound and photobiomodulation on the symptoms and evaluate the participation of spinal glia in osteoarthritis-induced nociception in mice. Male Swiss mice were subjected to osteoarthritis induction with a 0.1-mg intra-articular injection of monosodium iodoacetate. Additionally, the mice received chronic ultrasound or photobiomodulation treatment for 21 days or a single treatment at day 14. Nociception was evaluated using von Frey filaments, and osteoarthritis symptoms were assessed by analysis of gait, joint temperature, and knee joint diameter. The role of spinal microglia and astrocytes on nociception was evaluated via an intrathecal injection of minocycline or fluorocitrate, and the spinal release of IL-1β and TNF-α was assessed by ELISA after chronic treatment with ultrasound or photobiomodulation. Our data showed that both single and chronic treatment with ultrasound or photobiomodulation attenuated the osteoarthritis-induced nociception. No differences in gait, knee joint temperature, or knee joint diameter were found. The intrathecal injection of minocycline and fluorocitrate decreased the osteoarthritis-induced nociception. There was an increase in the spinal levels of TNF-α, which was reverted by chronic ultrasound and laser treatments. These results suggest that osteoarthritis induces nociception and glial activation via spinal release of TNF-α and that the chronic treatment with ultrasound or photobiomodulation decreased nociception and TNF-α release.

The LD (Linz Donawitz) steelmaking process is the most used in the steel industry due to its high-volume capacity and low cost per ton of steel produced. However, the basic oxygen steelmaking proce...

Introdução: A crescente prevalência de obesidade e doenças cardiovasculares (DC) atenua a saúde da população, aumentando os gastos dos sistemas de saúde pública. A prática de exercício físico pode auxiliar na prevenção e/ou tratamento dessas doenças, sendo utilizada por programas do governo como o Núcleo de Apoio à Saúde da Família (NASF). Objetivo: Verificar os efeitos crônicos da prática de exercícios físicos do NASF em marcadores de obesidade e DC de sujeitos obesos. Métodos: Foi realizado um estudo transversal retrospectivo, composto pela análise de marcadores de obesidade e DC de 100 mulheres após 15 meses de treinamento em circuito. O teste de Friedman foi utilizado para comparações múltiplas do índice de massa corporal (IMC) e circunferência do abdome (CABD) entre os meses 1, 5, 10 e 15. Resultados: Foram encontradas diferenças significativas no IMC entre os meses 1, 5,10 e 15 (33,4±5,5, 31,6±5,5, 29,3±5,2 e 27,7±5,0, respectivamente. p

Nas empresas do setor de energia elétrica as demonstrações contábeis devem ser apresentadas conforme a Contabilidade Societária e a Contabilidade Regulatória. Sendo assim, esta pesquisa objetiva verificar, entre o modelo contábil societário e regulatório, qual melhor explica a variação do preço das ações das companhias elétricas brasileiras no período entre 2011 e 2018. As informações foram coletadas na base de dados da Economatica® e no sítio eletrônico da Agência Nacional de Energia Elétrica (ANEEL). A análise foi feita por meio de regressões múltiplas com dados em painel e os modelos foram estimados com base na metodologia de Collins, Maydew e Weiss (1997), desenvolvida a partir de Ohlson (1995). Os resultados apontaram que o modelo societário apresenta poder explicativo superior (R² de 65,39%) em comparação ao modelo regulatório (R² de 58,96), portanto não se rejeita a hipótese de pesquisa levantada de que as informações contábeis societárias são mais relevantes para os investidores em relação às informações contábeis regulatórias. Além disso, a análise adicional indicou que, ao segregar o período de investigação em 2011-2014 (período anterior à vigência da Orientação Técnica do Comitê de Pronunciamentos Contábeis (OCPC) 08) e em 2015-2018 (período posterior à vigência da OCPC 08), no anterior somente as informações contábeis regulatórias foram estatisticamente significativas e no posterior o modelo societário (R² de 73,37%) denotou maior relevância em relação ao modelo regulatório (R² de 65,41%). Essa maior relevância pode estar atrelada ao fato de que enquanto as demonstrações contábeis societárias têm como base os princípios, as demonstrações contábeis regulatórias do setor elétrico se fundamentam em regras fiscais e tarifárias específicas.

Introduction and objective Sickle cell anemia (SCA) is a genetic condition that alters the conformation of deoxygenated red blood cells, which results in their stiffening and the occurrence of vaso-occlusive crises, endothelium damage, organ dysfunction and systemic complications. Additionally, SCA limits the participation of individuals in physical and social activities. As we consider that physical exercise promotes the recovery of functional capacity and cardiorespiratory conditioning, we aim to verify the patterns of prescription, the effects and safety of exercise for individuals with SCA. Methodology We systematically reviewed the published literature focusing on clinical trials that correlated physical exercise with SCA patients and cross-sectional studies that applied the stress test. The data research was based on the PRISMA recommendations and the following databases were used: Medline by PubMed, Cochrane, PEDro, Scielo. Results Six studies which were based on the evaluation of 212 patients aged between 13 and 40 years, were selected from 122 identified studies. Those studies associated the individual effort tolerance improvement, its inflammatory profile adjustment and the absence of alteration in the autonomic nervous system activity to physical exercise or stress test. Conclusion Low-to-moderate intensity physical exercise increased the SCA individual tolerance without causing vaso-occlusive crises, nor changes in the hemorheological and inflammatory profiles.

Epilepsy is the most common chronic neurologic disorder in the world, affecting 1-2% of the population. Besides, 30% of epilepsy patients are drug-resistant. Genomic mutations seem to play a key role in its etiology and knowledge of strong effect mutations in protein structures might improve prediction and the development of efficacious drugs to treat epilepsy. Several genetic association studies have been undertaken to examine the effect of a range of candidate genes for resistance. Although, few studies have explored the effect of the mutations into protein structure and biophysics in the epilepsy field. Much work remains to be done, but the plans made for exciting developments will hold therapeutic potential for patients with drug-resistance. In summary, we provide a critical review of the perspectives for the development of individualized medicine for epilepsy based on genetic polymorphisms/mutations in light of core elements such as transcriptomics, structural biology, disease model, pharmacogenomics and pharmacokinetics in a manner to improve the success of trial designs of antiepileptic drugs.

Introdução: Uma doença altamente infecciosa do trato respiratório, a doença de coronavírus 2019 (COVID-19) pode causar disfunção respiratória, física e psicológica em pacientes. Portanto, a reabilitação pulmonar é crucial para pacientes admitidos e que recebem alta da COVID-19. As sequelas de longo prazo são desconhecidas, mas as evidências de surtos anteriores de CoV demonstram comprometimento da função pulmonar e física, redução da qualidade de vida e sofrimento emocional. Métodos: Trata-se de uma revisão sistemática da literatura realizada através de busca digital em artigos publicados em revistas impressas e eletrônicas, ensaios clínicos, estudos randomizados, revisões sistemáticas, no período compreendido entre os anos de 2003 e 2020. Resultados: Muitos sobreviventes da COVID-19 que necessitam de cuidados críticos podem desenvolver comprometimentos psicológicos, físicos e cognitivos. Conclusão: Existe uma clara necessidade de orientação sobre a reabilitação dos sobreviventes da COVID-19.

MARCO LEGAL PARA COMÉRCIO DE ENERGIA EM USINA SUCROALCOOLEIRA SOLAR HÍBRIDA ALCIR MONTEIRO COLLAÇO1, PEDRO HENRIQUE SILVA BEZERRA2, RENAN DE SOUZA CARVALHO3, CELSO LINS DE OLIVEIRA4 1Professor. Universidade de Mogi das Cruzes, Campus Villa-Lobos. Av. Imperatriz Leopoldina, 550, Vila Leopoldina. 05305-060. São Paulo, SP, Brasil. E-mail:alcir.collaco@hotmail.com 2Professor Adjunto. Universidade do Estado de Mato Grosso “Carlos Alberto Reyes Maldonado”, Campus de Nova Mutum. Av. das Garças, 1192, Jardim das Orquídeas. 78450-000. Nova Mutum, MT, Brasil. E-mail: pedro.bezerra@unemat.br 3Mestre em Tecnologia da Energia. Instituto de Energia e Ambiente. Universidade de São Paulo. Av. Prof. Luciano Gualberto, 1289, Butantã. 05508-010. São Paulo, SP, Brasil. E-mail: renan2.scarvalho@gmail.com 4Professor Titular no Departamento Engenharia de Biossistemas. Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos. Av. Duque de Caxias Norte, 225, Campus Pirassununga. 13635-900. Pirassununga, SP, Brasil. E-mail: celsooli@usp.br RESUMO: A utilização de fontes de energias renováveis em sistemas agroindustriais, têm sido uma alternativa no processo de transição energética. No mercado de energia, o principal quesito para a seleção do tipo de geração ainda é o custo. O objetivo deste trabalho, foi demonstrar o desempenho energético de 4 modelos de sistemas heliotérmicos híbridos, acoplados a uma usina sucroalcooleira, atuando no atual mercado de energia por meio do comércio da energia gerada excedente ao consumo. O software System Advisor Model (SAM), foi utilizado nas simulações para a obtenção do desempenho energético e do custo nivelado da energia gerada (LCoE). Os casos foram dimensionados a atender a carga de consumo de uma usina sucroalcooleira, operando em resposta ao recurso solar. A hibridização de sistemas (Concentrated Solar Power) CSP de geração com biomassa disponível durante parte do ano contribui para um bom fator de capacidade. Sistemas de geração, que operam com duas fontes distintas, possibilitam mais segurança de entrega e minimizam riscos, o que contribuiu na formulação do contrato de energia. Os entraves do mercado de energia são possíveis de serem solúveis por meio da aplicação de políticas públicas energéticas, de forma a alavancar a competitividade da tecnologia CSP em relação às demais. Palavras-chave: energia solar concentrada, geração híbrida, usina sucroalcooleira, mercado de energia, contrato de energia. LEGAL FRAMEWORK FOR ENERGY TRADE IN HYBRID SOLAR SUGAR ALCOHOL POWER PLANT ABSTRACT: The use of renewable energy sources in agro-industrial systems has been an alternative in the energy transition process. In the energy market, the main issue for selecting the type of generation still the cost. This paper aimed to demonstrate the energy performance of 4 models of hybrid heliothermic systems, coupled to a sugar and alcohol power plant, operating in the current energy market through the trade of energy generated in excess of consumption. To obtain the energy performance and the leveled cost of energy (LCoE), simulations were carried on the software System Advisor Model (SAM). The cases were sized to meet the consumption load of a power plant, operating in response to the solar resource. The hybridization of CSP (Concentrated Solar Power) systems with biomass available during part of the year can increase the capacity factor. Generation systems, which operate from two sources, provide more secure delivery of energy and minimize risks, which contributed to the formulation of the energy contract. The obstacles in the energy market are possible to be solved through the application of public energy policies, in order to leverage the CSP technologies’ competitiveness regarding other green technologies. Keywords: concentrated solar power, hybrid generation, sugar/alcohol power plant, energy market, energy contract.

The sugarcane cystatin (CaneCPI-5) was recently cloned and showed strong binding force to dental enamel and protection against initial erosion. However, evaluations on its safety and efficacy in a situation closer to the clinical condition are necessary. In the present study we analyzed 1) the cytotoxicity of CaneCPI-5 on human gingival fibroblasts (HGFs); 2) the ability of CaneCPI-5 to reduce enamel erosion and erosion+abrasion in situ. In part 1, HGFs were treated with CaneCPI-5 (0.025, 0.05, 0.1, 0.5 or 1.0 mg/mL) or no treatment (control). The cytotoxicity was assessed after 60 s and 24 h by mitochondrial activity (MTT), confocal microscopy, and hematoxylin/eosin staining. In part 2, 15 volunteers participated in a double-blind crossover protocol consisting of 3 phases, according to the following treatments: 1) 0.1 mg/mL CaneCPI-5; 2) SnCl2/NaF/AmF (Elmex; positive control); 3) water (negative control). The volunteers wore an appliance containing 4 bovine enamel specimens for 5 d. Each day, the specimens were individually treated with 50 µL of the tested solutions per 60 s and then subjected to erosive challenges (0.1% citric acid, pH 2.5, for 90 s, 4 times per day). After the first and last erosive challenge each day, 2 samples were abraded (toothbrushing, 15 s). Enamel wear was measured by contact profilometry. One or two-way analysis of variance (ANOVA)/Tukey’s or Sidak’s tests ( P < 0.05) were applied. Regardless of the concentration and the experimental time, CaneCPI-5 did not decrease the cell viability compared to the negative control ( P < 0.05). Erosion+abrasion led to significantly greater wear compared to erosion only. For both conditions, the lowest wear was found for SnCl2 and CaneCPI-5, which did not differ significantly from each other, but showed significant protection when compared to the negative control. In conclusion, CaneCPI-5 is safe on HGFs and reduces enamel erosive wear to the same extent as a commercial solution used to control erosive tooth wear (ETW).

Recent evidences have shown the therapeutic potential of transcranial photobiomodulation on traumatic brain injury and Alzheimer's disease. Despite the promising benefits in the brain, little is known about the laser's effects in the absence of pathological conditions. We submitted young (4 months old) and aged (20 months old) rats to transcranial low-level laser and evaluated their exploratory activity and habituation in open field, anxiety in elevated plus maze, spatial memory in Barnes maze, and aversive memory in a step-down inhibitory avoidance task. Additionally, the levels of a panel of inflammatory cytokines and chemokines were quantified in two different brain regions: the cerebral cortex and the hippocampus. Young and aged rats submitted to transcranial laser exhibited better cognitive performance in Barnes maze than did control rats. Transcranial laser therapy decreased cortical levels of GM-CSF, IL-10, MCP-1, LIX, and TNFα in young rats and IL-5 in aged rats. High levels of IL-6, IL-10, and TNF-alpha were found in the cerebral cortex of aged rats submitted to transcranial laser. In the hippocampus, a decrease in IP-10 and fractalkine levels was observed in the aged rats from the laser group when compared to the aged rats from the control group. Our data indicate that transcranial photobiomodulation improves spatial learning and memory and alters the neuroinflammatory profile of young and aged rats' brains.

Considerando que as empresas vivem em um cenário competitivo mais agressivo e dinâmico, a gestão da produção torna-se cada vez mais necessária. Sendo assim, a programação e o sequenciamento da produção aparecem como diferenciais no que diz respeito a fatores de extrema importância em uma linha produtiva. Neste contexto, o foco deste trabalho foi utilizar o software Preactor AS Express 2016® para simular o método de sequenciamento atual da empresa estudada e, também, outros métodos oferecidos pelo software, a fim de encontrar aquele que fosse mais ágil e eficiente. A metodologia utilizada foi o estudo de caso tendo como foco um cliente especifico da empresa, que representa 74,02% do faturamento anual. A obtenção dos dados se deu através da coleta e análise documental dos dados das ordens de produção deste cliente nos meses de Setembro e Dezembro de 2019, sendo esses os de maior participação do cliente no ano. Os dados foram importados no software e diferentes alternativas foram analisadas e, após estas análises, foi possível identificar que a alternativa de sequenciamento utilizada pela empresa era viável em meses cujos prazos de produção fossem maiores, já o método proposto se adequava com eficiência mesmo em meses mais emergentes. Por fim, concluiu-se que o método de sequenciamento utilizado pela empresa não é o mais adequado, haja visto que meses emergentes são mais comuns durante todo o ano, assim recomenda-se para a empresa a utilização do método Para trás por ordem de entrega

A pancreatite configura-se como uma das doenças mais comuns dentro da rotina médico veterinária. É considerada uma doença inflamatória grave, de caráter agudo e/ou crônico, e que ainda é subdiagnosticada devido a impasses existentes na determinação da doença. Os animais mais afetados são cães, de meia idade e idosos e algumas raças podem ser consideradas como mais predispostas a adquirirem a condição. Os pacientes afetados apresentam sintomatologia variada, a depender da gravidade da doença. O diagnóstico pode ser difícil devido a pancreatite possibilitar inúmeros sintomas semelhantes com outras doenças gastroentéricas. O uso combinado de estratégias diagnósticas como exames laboratoriais e de imagem, além dos dados colhidos através do exame físico e anamnese, possibilitam a análise sistêmica da condição e a escolha da terapia. O manejo terapêutico apropriado pode reduzir a morbidade e mortalidade na pancreatite.

Objetivo: Analisar se a relevância da informação contábil, em relação ao valor de mercado, possui características diferentes nas empresas do segmento de construção civil e incorporação imobiliária em comparação com entidades dos demais segmentos. Metodologia: A janela temporal da pesquisa abrangeu o período de 2011 a 2017, sendo a amostra final composta por 182 empresas listadas na Bovespa, das quais 20 são do setor de construção civil e incorporação imobiliária. Foi estimada regressão com dados em painel de efeitos fixos com base no modelo econométrico desenvolvido por Barth, Clinch e Israeli (2016). Resultados: Os resultados apontam que, em relação às empresas que não são do segmento de construção civil, o mercado atribui relevância a todas as variáveis contábeis presentes no modelo. Já em relação às empresas do setor de construção civil e incorporação imobiliária os resultados trazem evidências estatísticas de que, em relação ao valor de mercado, os números contábeis das entidades do setor de construção civil e incorporação imobiliária possuem relevância informacional diferente das entidades brasileiras dos demais segmentos. Os resultados também indicam que os métodos de reconhecimento de receitas específicos adotados pelo setor de construção civil e incorporação refletem na relevância de seus números contábeis em relação ao valor de mercado das empresas. Contribuições do Estudo: O estudo contribui com a literatura atual ao analisar a o poder informacional dos relatórios financeiros em um setor específico. Os resultados contribuem com os profissionais que elaboram as demonstrações financeira pois sinaliza a necessidade de melhoria da qualidade informacional. Também sinaliza aos agentes normatizadores que as normas destinadas especificamente a estes setores, podem estar acarretando a redução da qualidade informacional das demonstrações financeiras.

Este artigo relata resultados de uma pesquisa que teve por objetivo analisar criticamente a abordagem sobre Gestão Financeira Pessoal apresentada pela coleção de livros “Educação Financeira nas Escolas – Ensino Médio”, disponibilizado pelo Ministério da Educação para as escolas brasileiras. A pesquisa, de cunho bibliográfico, tem aporte teórico na sociologia de Bauman e nas concepções de projeto e comunicação postuladas por Machado e Skovsmose. Apresentamos uma sistematização do material empírico selecionado e a abordagem das categorias custo, recebimento, planejamento, poupança e crédito. Enfatizamos os temas que transversa o conteúdo do material, o consumismo e projetos de vida, destacando a importância dos mesmos para pensarmos uma sociedade onde tenha lugar para todos. Por fim, apresentamos as conclusões, em que retomamos a proposta desenvolvida e destacamos potencialidades e fragilidades do material do MEC, objetivando analisar as abordagens das categorias e apresentando sugestões de melhorias, disposto a aprimorá-lo.

Background Amyotrophic Lateral Sclerosis (ALS) leads to a drastic reduction in quality of life, generating intense psychological distress and predisposing those affected to mental illness and, in more severe cases, suicidal behavior. Objective This is a systematic review aiming to estimate the frequency of wish to die, suicide ideation and suicide in individuals with ALS using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Methods The following databases were used: Pubmed/MEDLINE, PsycINFO, Embase, SciELO, Biblioteca Virtual de Saude (BVS), and Cochrane Library. The choice of appropriate descriptors, or their equivalents, to define the search terms was based on the technical and scientific vocabulary of each database. Results 13 articles were included in the present systematic review, of which three were cross-sectional studies, nine were cohort-type and there was one case-control study. The studies show that individuals with ALS have a higher risk of suicide in relation to the general population, and there is evidence that this risk is even higher in the early stages of the disease. Major Depressive Disorder was the most prevalent mental disorder in the studies included. This mental health concern is often undertreated, leading to the increased susceptibility of this population to suicide. Limitations In general, the study samples represent a highly heterogeneous population while many instruments used in the data collection were not uniform. Conclusions The high degree of psychological vulnerability of this population, associated with a greater predisposition to suicidal behavior, should be minimized through public health measures.

A insuficiência renal (IR) é caracterizada pela perda da capacidade dos rins em filtrar os resíduos metabólicos, sais e líquidos sanguíneos. As principais causas desta moléstia são a hipertensão arterial sistêmica e a diabetes mellitus descontrolada [1,2]. Entretanto, outras causas são descritas, como o uso de fármacos nefrotóxicos, desidratação prolongada, infecção e outros fatores que contribuem para a lesão renal [1]. A IR pode ser classificada em aguda (rápida e reversível) e crônica (gradual, lenta e sem reversibilidade) [1,2]. Estas doenças representam um grave problema de saúde pública no Brasil, estima-se que 134 mil doentes renais crônicos necessitam de terapia substitutiva (hemodiálise) [3]. Estes números crescem a cada ano, somente no ano de 2018 foram diagnosticados 42.546 novos casos de indivíduos que necessitaram desta terapia [3].

Made available in DSpace on 2020-12-12T02:22:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) This article proposes a calculation methodology that starts from the demand calculation to supply a fleet bus with renewable hydrogen based on the electrolysis process until the energetic, economic, and environmental analyses, involving all the processes of the productive chair. Also considering the dynamic behaviour of the following hydrogen processes: production, storage, and use. The simplified scheme of the proposed system configuration to be studied consists of the use of alternative and renewable sources of energy (solar-wind-biogas) to generate electrical energy in order to produce hydrogen from electrolysis of the water, which is stored in its gaseous state and subsequently redirected to a filling station to be used as vehicle fuel in buses. The results show that to feed one bus the hybrid system generates an average of 78,110 kWh/month with an installed capacity of 1101.905 kW, producing 1209.90 kgH2/month through the electrolysis process from water. The results also show a range of electricity generation costs between 1.130 and 0.123 US$/kWh and H2 production between 0.963 and 0.110 US$/kWh. Concluding that the application of renewable energies to produce hydrogen and electricity for the public transport sector is an attractive alternative in the future throughout the country, because the proposed system is technically, economically and ecologically viable. São Paulo State University (UNESP) School of Engineering Department of Energy, Av. Ariberto Pereira da Cunha, 333, Portal Das Colinas Laboratory of Optimization of Energy Systems (LOSE) Institute of Bioenergy Research (IPBEN - UNESP) – Associated Laboratory of Guaratinguetá University of São Paulo (USP) Lorena School of Engineering Anhanguera Faculty Department of Electrical Engineering, Ave. Nossa Sra. do Bonsucesso São Paulo State University (UNESP) School of Engineering Department of Energy, Av. Ariberto Pereira da Cunha, 333, Portal Das Colinas Laboratory of Optimization of Energy Systems (LOSE) Institute of Bioenergy Research (IPBEN - UNESP) – Associated Laboratory of Guaratinguetá CNPq: 300992/2018–1 CNPq: 301817/2019–7

Made available in DSpace on 2021-06-25T15:38:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-16 Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Artemisinin (ART) was initially described for the control of inflammation and pain. However, the mechanisms involved with its antinociceptive effect are still poorly understood. Thus, this present study aimed to investigate the effect of ART in both free and nanocapsulated form on postoperative pain, as well as the participation of the spinal Toll-like receptor 4 (TLR4) in this process. Postoperative pain was induced using the skin/muscle incision retraction (SMIR) model in male Swiss mice. After 3 and 28 days of SMIR, the animals received an intrathecal injection of free or nanocapsulated ART, and the nociceptive threshold was evaluated by von Frey filament test. To evaluate the involvement of the microglia, astrocytes, and TLR4, minocycline (a microglia inhibitor), fluorocitrate (an astrocyte inhibitor), andLipopolysaccharide Rhodobacter sphaeroides(LPS-RS), a TLR4 antagonist, were intrathecally injected on the third day of SMIR. The levels of spinal TLR4 protein and proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), and interleukin-1-beta (IL-1 beta) were quantified by western blot and enzyme-linked immunosorbent assay, respectively. The results showed that free ART reduced postoperative pain (P < 0.001,F-5,F-30 = 7.49, 16.66% for 1000 ng dose; andP < 0.01,F-5,F-30 = 7.49, 14.58% for 500 ng dose) on the 3rd day of SMIR; while the ART nanocapsule had this effect on both the third (P < 0.001;F-5,F-30 = 4.94; 43.75, 39.58 and 72.91% for the 250, 500 and 1000 ng doses, respectively) and 28th (P < 0.05;F-5,F-30 = 7.71; 29.16 and 33.33% for the 500 and 1000 ng doses, respectively) day. The ART nanocapsule had a more potent and longer antinociceptive effect than free ART or morphine. Postoperative pain was also reduced by minocycline and LPS-RS. The ART nanocapsule also reduced the increased levels of TLR4, TNF-alpha, and IL-1 beta induced by SMIR. These data suggest that the ART nanocapsule has a potent analgesic effect on postoperative pain at the spinal level, and this response involves the inhibition of TLR4 and the proinflammatory cytokines TNF-alpha and IL-1 beta. Univ Fed Alfenas, Fac Motr Sci, Sci Motr Inst, Jovino Fernandes Sales Ave 2600, BR-37133840 Alfenas, Brazil Univ Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, Brazil Sao Paulo State Univ, Inst Sci & Technol, Sorocaba, Brazil Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, Brazil Sao Paulo State Univ, Inst Sci & Technol, Sorocaba, Brazil CAPES: 001 FAPESP: 2014/16008-3

Communication and information technologies are increasingly influencing health actions, as well as patient safety. Thus, this study aimed to develop an application for conference and control of all stages of the Safe Surgery checklist suggested by the World Health Organization improving the safety of patients submitted to surgery. The problem of research lies precisely in the absence of mobile applications capable of meeting the need for patient safety. This study is applied in the technological development of an application with the possibility of deployment in any health service and easy installation on mobile devices. The app was built based on the Safe Surgery checklist established by the World Health Organization. The application allows patient identification through three identifiers. Later it contemplates all the items of the three stages of the checklist of safe surgery: Before anesthetic induction, Before the Surgical Incision and Before the Patient Leaves the Room. At the end of all the steps of the application, it calculates the risk to patient safety. The application developed is a tool that can be implemented in health institutions and used by professionals working in the operating room.

As modalidades de estimulação elétrica (EE) podem ser utilizadas para promover alívio de dor ou gerar força muscular. Entretanto, observa-se que existem poucos estudos que analisam o Limiar de Tolerância de Dor à Pressão (LTDP) em parâmetros que promovem fortalecimento muscular. Objetivamos verificar e comparar o LTDP após a EE com parâmetros indicados para o fortalecimento muscular em indivíduos saudáveis. Para isso participaram 51 mulheres randomizadas em três grupos (n=17 cada): RUSSA, AUSSIE e FES. A EE foi aplicada por 10 minutos com intensidade em nível motor no músculo quadríceps direito. O quadríceps esquerdo foi utilizado como controle. Avaliou-se o LTDP no músculo reto femoral pela algometria de pressão antes, imediatamente após, 30 minutos após e 1 hora após a eletroestimulação. Quando comparado com o controle, o grupo FES apresentou aumento estatisticamente significativo no LTDP imediatamente após a EE (p=0,009), enquanto o grupo RUSSA apresentou diferença estatística 30 minutos após a EE (p=0,007), mas com aumento significativo no lado controle. No grupo AUSSIE não houve diferença estatística entre os lados em nenhuma das situações avaliadas. Na comparação entre os momentos avaliados no lado experimental, o grupo FES apresentou um aumento significativo no LTDP imediatamente após e 30 minutos após a EE (p=0,03). As demais comparações não apresentaram diferenças significativas. Os dados deste estudo sugerem que a EE pode aumentar o LTDP por meio da corrente FES, quando utilizada com parâmetros para fortalecimento muscular.

Arugula is a crop of fast vegetative growth and short cycle, widely accepted worldwide. In Brazil, its production generates jobs and income for family farming. However, the use of saline water in the cultivation of this plant is one of the main factors that limit production. Given this situation, the objective of this study was to evaluate the growth of Apreciatta arugula cultivated under conditions of shading and salinity levels of irrigation water. The experiment was conducted in a greenhouse in the experimental area of the Agricultural Sciences Center of the Federal University of Alagoas, in the city of Rio Largo, AL. The treatments were obtained from the combination of two shading conditions (with shading and without shading) and five levels of electrical conductivity of the irrigation water (0.5; 2.0; 3.5; 5.0 and 6.5 dS m-1). The experimental design used was completely randomized in a 2 x 5 factorial scheme. Combined, the factors resulted in 10 treatments with four replications and one plant per plot, totaling 40 experimental units. Arugula plants were evaluated for leaf number, plant height, leaf area and dry matter of the aerial part. Increasing levels of salinity in the irrigation water, lead to a reduction in the number of leaves, plant height and dry mass of the aerial part of arugula plants cultivar Apreciatta. However, the use of shading together with the salinity of irrigation water up to 1.4 dS m-1does not affect the leaf area of arugula plants, being possible to cultivate without considerable losses.

Body posture and movement seem to be responsible for multiple variations of microcirculation in the foot, although difficulties associated with measurement during movement have limited their characterization. This pilot study sought to explore a new non-invasive instrument based on polarized light spectroscopy – the TiVi system, under orthostatic and dynamic conditions. Five healthy participants (duly informed, 26.0 ± 6.5 years of age) of both genders were selected. The protocol involved sequential posture changes (orthostatic variation) and dynamic movements (squatting and unipodal flexion). Perfusion variations were evaluated in both feet by laser-Doppler flowmetry (LDF) and polarized spectroscopy (TiVi). Both systems revealed the same type of modification of these flow-related variables. The most pronounced changes were obtained with exercise, especially with squatting, which caused a marked increase in foot perfusion. Less dramatic but in the same direction, the increased perfusion with unipodal flexion was also observed in the contralateral limb. This study confirmed the interest in using the TiVi system in these domains, as well as the appropriateness of this experimental design to look deeper into the impact of lower limb movement on the functional dynamics of the foot.

The immune system plays an essential role in the COVID-19 pandemic, as it is involved in the pathogenesis and worsening of the disease. The purpose of this review is to address aspects of innate immunity in COVID-19, especially the role of neutrophils. The innate immune system corresponds to the organism's first defense, but a balance must be effective against the invader without harming the host excessively. An immune imbalance is related to more severe conditions and aberrant neutrophil activation, with lymphopenia and neutrophilia being predictors of a worse prognosis in patients with COVID-19. Neutrophilia is speculated to be an important source for the excessive formation of NET (Neutrophil Extracellular Traps), leading to increased inflammatory response and unfavorable evolution of the disease. NETs are also associated with the cytokine storm, another mechanism related to COVID-19's gravity. Therefore, strategies involving immunomodulation may have an essential role in controlling the disease. O sistema imune apresenta papel importante na pandemia da COVID-19, pois está envolvido na patogênese e agravamento da doença. O objetivo desta revisão é abordar os aspectos da imunidade inata na COVID-19, especialmente o papel dos neutrófilos. O sistema imune inato corresponde à primeira defesa do organismo, porém é necessário um equilíbrio para obter efetividade contra o invasor sem lesar excessivamente o hospedeiro. O desequilíbrio imune está relacionado com quadros mais graves e à ativação aberrante de neutrófilos, sendo a linfopenia e a neutrofilia preditores de pior prognóstico em pacientes com COVID-19. Especula-se que a neutrofilia seja uma importante fonte para formação excessiva de NET (Neutrophil Extracellular Traps), levando ao aumento da resposta inflamatória e evolução desfavorável da doença. As NET também estão associadas à tempestade de citocinas, outro mecanismo relacionado a gravidade da COVID-19. Portanto, estratégias que envolvam a imunomodulação podem ter um papel importante no controle da doença.

Objectives: to describe the characteristics of pneumonia hospitalizations in children under five years of age across the State of Maranhão, Brazil, and explore patterns of spatial distribution of admissions. Methods: ecological study using data on occurrences (age, gender, skin color/race, month of occurrence, and municipality of residence) between 2012 and 2017 taken from the Unified Health System’s Hospital Information System and municipal level socioeconomic indicators for 2010. Each respiratory disease, including pneumonia, was presented as a percentage of overall admissions for respiratory tract diseases, together with the monthly distribution of admissions as a percentage of total annual cases, and annual rate of admissions by gender. The General G* statistic was calculated to identify significant clustering of municipalities with similar proportions of hospital admissions for pneumonia relative to overall hospital admissions. Results: pneumonia was the leading cause of admissions for respiratory disease, accounting for 57% of all cases and occurring with greater frequency in the rainy season (February to June) and in cities with lower socioeconomic indicator values. The rate of admissions decreased over the study period. Significant clusters (p

Massage is commonly used as a complementary therapy for many different conditions. Demonstration of its physiological impact and understanding of its therapeutic mechanisms is still insufficient and often inconclusive. This study aims to characterize the physiological effects of effleurage, one of the most popular techniques, on human in vivo microcirculation and its impact on cardiovascular function. Two differently oriented variations of the technique, referred to influence physiological outcomes, were applied to 32 young (mean 19.8 ± 1.6 yr old) healthy volunteers of both sexes in a single, randomly chosen limb after informed written consent. Each protocol included a 10-min baseline (

People use Online Social Networks (OSNs) to express their opinions and feelings about many topics. Depending on the nature of an event and its dissemination rate in OSNs, and considering specific regions, the users’ behavior can drastically change over a specific period of time. In this context, this work aims to propose an event detection system at the early stages of an event based on changes in the users’ behavior in an OSN. This system can detect an event of any subject, and thus, it can be used for different purposes. The proposed event detection system is composed of the following main modules: (1) determination of the user’s location, (2) message extraction from an OSN, (3) topic identification using natural language processing (NLP) based on the Deep Belief Network (DBN), (4) the user behavior change analyzer in the OSN, and (5) affective analysis for emotion identification based on a tree-convolutional neural network (tree-CNN). In the case of public health, the early event detection is very relevant for the population and the authorities in order to be able take corrective actions. Hence, the new coronavirus disease (COVID-19) is used as a case study in this work. For performance validation, the modules related to the topic identification and affective analysis were compared with other similar solutions or implemented with other machine learning algorithms. In the performance assessment, the proposed event detection system achieved an accuracy higher than 0.90, while other similar methods reached accuracy values less than 0.74. Additionally, our proposed system was able to detect an event almost three days earlier than the other methods. Furthermore, the information provided by the system permits to understand the predominant characteristics of an event, such as keywords and emotion type of messages.

In this paper, we aimed at selecting genotypes of Coffea arabica L. that are responsive to framework prunin, with high productive potential and desirable agricultural features. We evaluated 18 progenies in the F5 generation, 8 of them being from the group Catucai (breeding of seedlings of Red Catuai with coffee seeds of the Icatu germplasm) and ten descendants from the Timor Hybrid (breeding of the Red and Yellow Catuai with the Timor Hybrid), as well as two commercial cultivars as witnesses (Tupi IAC 1669-33 and Obata IAC 1669-20). The experiment was carried out at the experimental field of the Federal University of Lavras. The coffee was pruned in August 2014 after the sixth crop and once again in August 2016, being two cycles in the “safra zero” system. The design used was in randomized blocks (RBD) with three repetitions and 20 treatments (18 progenies and two commercial cultivars) totaling 60 experimental plots. We evaluated the area under the progress curve of incidence and severity of leaf rust and cercosporiosis, the productivity (sacs ha-1), sieve #16 and over (%), mocha-type grains (%) and apparent specific mass of grains (ton.m3). The genotype 12 (H516-2-1-1-18-1-4) was responsive to the framework pruning and kept its productivity stable in both pruning cycles, being efficient in such system of crop conduction, besides presenting low incidence and severity of coffee leaf rust and cercosporiosis and high sieve. Key words: Timor hybrid; Cercosporiosis; Leaf rust.

We provide novel data on anti-SARS-CoV-2 immunogenicity decay and incident cases six months after the 2nd dose of Sinovac-CoronaVac inactivated vaccine(D210) in 828 autoimmune rheumatic diseases(ARD) patients compared with 223 age/sex-balanced control group(CG). From D69 to D210, anti-S1/S2IgG positivity and GMT reduced 23.8% and 38% in ARD(p

The Covid-19 pandemic has created an unprecedented need for epidemiological monitoring using diverse strategies. We conducted a project combining prevalence, seroprevalence, and genomic surveillance approaches to describe the initial pandemic stages in Betim City, Brazil. We collected 3239 subjects in a population-based age-, sex- and neighbourhood-stratified, household, prospective; cross-sectional study divided into three surveys 21 days apart sampling the same geographical area. In the first survey, overall prevalence (participants positive in serological or molecular tests) reached 0.46% (90% CI 0.12% – 0.80%), followed by 2.69% (90% CI 1.88% – 3.49%) in the second survey and 6.67% (90% CI 5.42% - 7.92%) in the third. The underreporting reached 11, 19.6, and 20.4 times in each survey, respectively. We observed increased odds to test positive in females compared to males (OR 1.88 95% CI 1.25 – 2.82), while the single best predictor for positivity was ageusia/ anosmia (OR 8.12, 95% CI 4.72 – 13.98). Thirty-five SARS-CoV-2 genomes were sequenced, of which 18 were classified as lineage B.1.1.28, while 17 were B.1.1.33. Multiple independent viral introductions were observed. Integration of multiple epidemiological strategies was able to describe Covid-19 dispersion in the city adequately. Presented results have helped local government authorities to guide pandemic management.

This study proposes a selection strategy to be applied to a large number of coffee accessions, which can be useful when exploring many genotypes in breeding programs for beverage quality. Over three consecutive years, 270 Arabica coffee accessions from the Germplasm Bank of Minas Gerais, Brazil, were sensorially characterized. At the end of this period, the 20 genotypes with the greatest potential for specialty coffee production were selected, which were subjected to a second sensory characterization. Additionally, we determined the genetic correlations between the attributes that make up the final beverage score. We did not identify an attribute that was more important than the others in the organoleptic performance of the studied accessions. Through the proposed method, we identified genetic variation in our original population and selected five accessions with beverage quality considered excellent according to the SCA classification. These accessions were planted in field conditions of highly specialized farms to study their interaction with the cultivation environment and to promote the increase in production of such coffees. Additionally, the five selected accessions are being used in crosses with elite cultivars create new segregating populations. We conclude that estimation of the heritable variation of each accession, the use over the years of common check cultivars with known performance, and extremely care of experimental precision in the entire processes warrant fair comparisons.

Sars-Cov-2 has been the subject of study in the most diverse medical fields, since the pandemic began in China in late 2019. According to the American College of Cardiology, individuals with comorbid conditions have a hospitalization rate of 50%, when affected by COVID-19. It is observed that patients with comorbidities, such as arterial hypertension and diabetes, in addition to elderly individuals, have a higher rate of hospitalization due to the infection of the new coronavirus, as well as the aforementioned case. In view of the current pandemic and a disease still under investigation, all information about the clinic, treatment, complementary exams and patient monitoring can generate better knowledge about the characteristics of the infection and the development of treatment protocols. Therefore, with pharmacological management still uncertain, the use of antivirals, such as Oseltamivir, anticoagulants and 3rd generation cephalopsorins, have created positive perspectives regarding the prognosis of patients infected with Sars-Cov-2. Therefore, with pharmacological management still uncertain, the use of antivirals, such as Oseltamivir, anticoagulants and 3rd generation cephalopsorins, have created positive perspectives regarding the prognosis of patients infected with Sars-Cov-2.

In this work, circular economy was investigated for commercial indium tin oxide (ITO) thin films deposited on glass substrates obtained from degraded organic light-emitting diodes (OLED). These devices were assembled and polarized at laboratory in a previous work. For each substrate, with geometry 2.5 × 2.5 cm, four OLEDs with active area of 3 × 3 mm were set up. These OLED devices were assembled with ITO as the electrode anode and successive depositions of other materials (layer-by-layer), to form the complete structure. To obtain the recovered ITO, all layers were removed from the samples containing the OLEDs previously mounted, remaining only the ITO thin films, that were cleaned with commercial product together with the received ITO/glass samples. Both samples were compared using some techniques, such as: colorimetry, electrical resistance, and Raman spectroscopy. A methodology with light-emitting diode (LED) device polarized emitting light crossing the ITO thin films was used, and the luminance with chromaticity coordinates was obtained, revealing the good transparency of the thin films. Electrical resistance of recovered ITO revealed five higher orders of magnitude in comparison to the one of received ITO. This fact can be tributed to a poly(3,4-ethylenedioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS) layer, causing corrosion of the ITO thin films during the assembly of OLEDs or loss of the field lines created during the electrical measurements by probes of four-point probe. Raman spectroscopy did not show satisfactory results in the chemical composition analyses of the samples, but it indicated good cleaning process of the samples before the analyses.

Introduction The aim of the present study was to evaluate the presence of the median perforating canal (MPC) and its morphometric measurements in Cone Beam CT (CBCT) scans of adult patients, correlating the findings with sex, age and skeletal facial patterns. Material and Methods 717 CBCT scans were selected from a Brazilian population and the presence of the MPC was recorded. MPC diameter was measured in three points: lingual, medial and buccal. To determine the correlation between MPC presence and sex, age and ANB angle classifications the Chi-square test was performed. MPC diameters were related to sex, age and skeletal discrepancies using Mann-Whitney U and Kruskal-Wallis tests. The level of significance adopted was 5%. Results Of the 717 CBCT scans analyzed, the MPC was present in 181 patients (25.24%), 279 (38.91%) men and 438 (61.09%) women. The mean age was 37.91 (±14.46) years old, ranging from 18 to 88 years old. There were no differences in the presence of MPC between women and men (p= 0.85), between skeletal discrepancies (p= 0.09) and age groups (p= 0.94). Regarding the MPC diameter, statistical difference was found only for the medial diameter between sexes (p= 0.04), with the highest values in men. Conclusion The MPC was detected in 25.24% of the studied population, with significant differences only for its medial diameter in men.

The poor positioning of dental implants directly influences the functional and esthetic result of the implant-supported prosthesis. And as an alternative to correcting the positioning, prosthetic components such as prefabricated and customized abutments may be used. The current study aims to present an alternative resolution for malpositioned dental implants, with the hopes of minimizing damage to osseointegration and gingival tissues. A 53-year-old female patient had two implants in regions 11 and 21 with a height discrepancy of approximately 7 mm between them. The following treatment plan was proposed: the manufacture of two metal-free crowns and the use of a customized abutment to correct the height of the implant. A metal UCLA (Universal Long Castable Abutment) was used as a healer. The case includes 5 years of follow-up. It can be concluded that the use of a customized abutment as a prosthetic solution for an implant installed far below the cervical region of the tooth presented satisfactory esthetic and functional results with peri-implant bone maintenance and long-term gingival health.Descriptors: Dental Implantation; Dental Prosthesis, Esthetics, Dental.ReferênciasGoodacre CJ, Bernal G, Rungcharassaeng K, Kan JY. Clinical complications with implants and implant prostheses. J Prosthet Dent. 2003;90(2):121-32.Branemark PI, Hansson BO, Adell R, Breine U, Lindström J, Hallén O, et al. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand J Plast Reconstr Surg Suppl. 1977;16:1-132.Simensen AN, Bøe OE, Berg E, Leknes KN. Patient knowledge and expectations prior to receiving implant-supported restorations. Int J Oral Maxillofac Implants. 2015;30(1):41-7.Hyland R, Ellis J, Thomason M, El-Feky A, Moynihan P. A qualitative study on patient perspectives of how conventional and implant-supported dentures affect eating. J Dent. 2009;37(9):718-23.Arunyanak SP, Pollini A, Ntounis A, Morton D. Clinician assessments and patient perspectives of single-tooth implant restorations in the esthetic zone of the maxilla: A systematic review. J Prosthet Dent. 2017;118(1):10-17. Higginbottom FL. Implants as an option in the esthetic zone. J Oral Maxillofac Surg. 2005; 63(9 Suppl 2):33-44.Moráguez OD, Vailati F, Belser UC. Malpositioned implants in the anterior maxilla: a novel restorative approach to reestablish peri-implant tissue health and acceptable esthetics. Part II: Case report and discussion. Int J Esthet Dent. 2015;10(4):522-32.Pelekanos S, Pozi di G, Kourtis S. Restoration of divergent implants with a 2-piece screw-retained fixed, complete dental implant prostheses. J Prosthet Dent. 2016;115(4):389-92.DeFuria C, Weber HP, Kudara Y, Papaspyridakos P. Management of a Malpositioned Implant in the Anterior Maxilla. Compend Contin Educ Dent. 2017;38(3):e9-e12.Scutellà F, Weinstein T, Lazzara R, Testori T. Buccolingual implant position and vertical abutment finish line geometry: two strictly related factors that may influence the implant esthetic outcome. Implant Dent. 2015;24(3):343-8.Funato A, Salama MA, Ishikawa T, Garber DA, Salama H. Timing, positioning, and sequential staging in esthetic implant therapy: a four-dimensional perspective. Int J Periodontics Restorative Dent. 2007;27(4):313-23.Pjetursson BE, Asgeirsson AG, Zwahlen M, Sailer I. Improvements in implant dentistry over the last decade: comparison of survival and complication rates in older and newer publications. Int J Oral Maxillofac Implants. 2014;29 Suppl:308-24.Fuentealba R, Jofré J. Esthetic failure in implant dentistry. Dent Clin North Am. 2015;59(1):227-46.Kim DG, Elias KL, Jeong YH, Kwon HJ, Clements M, Brantley WA, et al. Differences between buccal and lingual bone quality and quantity of peri-implant regions. J Mech Behav Biomed Mater. 2016;60:48-55.Arai K, Takeda Y, Mori Y, Terauchi R, Furumori T, Tanaka S, et al. Analysis of factors associated with maintenance discontinuation in implant patients. Springerplus. 2015;12;4:767.

A mucosa vesical, na presença de agentes agressores, sofre alterações inicialmente benignas, mas com a cronicidade pode sofrer modificações potencialmente metaplásicas. A cistite glandular apresenta um quadro sintomático inespecífico, sendo necessária a realização de biópsia para seu diagnóstico e diferenciação histológica, podendo dividir-se em subtipos clássico e intestinal. Após análise de prontuário médico pertencente ao Hospital Santa Rita de Maringá, objetiva-se relatar o caso de um paciente masculino, de 32 anos, com disúria e dor em hipogástrico, apresentando em ultrassonografia lesão cística de 3,8 cm de diâmetro na bexiga. Após a retirada da lesão por ressecção transuretral, a análise histopatológica revelou presença de ninhos de Von Brunn, áreas de epitélio mucossecretor e mucina extracelular na mucosa vesical, propondo a existência de lesão glandular com metaplasia intestinal. Foi realizado estudo imuno-histoquímico para diagnóstico diferencial de adenocarcinoma mucossecretor bem diferenciado. A cistite glandular, quando manifestada macroscopicamente, assemelha-se a uma neoplasia por apresentar um aspecto irregular, difuso e algumas vezes ulceroso. Seu diagnóstico e tratamento podem ser simultâneos, porém, nos casos mais graves, as opções terapêuticas são restritas. O diagnóstico diferencial é extremamente importante para afastar a possibilidade de adenocarcinoma vesical, portanto, é imprescindível o acompanhamento periódico dos pacientes após o tratamento com a realização de exames específicos. O uso de marcadores imuno-histoquímicos tem se tornado relevante para o correto diagnóstico, pois genes relacionados ao ciclo celular, como o fator de transcrição homebox 2 do tipo caudal (CDX2), podem representar um vínculo entre o surgimento de metaplasia e sua possível progressão a adenocarcinoma.

Human tracking is an important challenge in a wide variety of applications, including but not limited to, surveillance, military operations, and disaster relief services. Unmanned Aerial Vehicles (UAVs) allow the surveying of dangerous or impassable areas from a safe distance. They also provide a machine-based capability, which may not only solve resource constraint issues, but can also improve effectiveness and efficiency in the tracking task. The effectiveness of tracking is directly related to the angle of view and degree of freedom of the camera system. In this paper, we introduce a decentralized, distributed deep learning algorithm for Real-Time Privacy-preserving Target Tracking Re-Identification (RPTT-ReID) used by cooperative UAVs in complex and adversarial environments involving motion, crowded scenes, and varied camera angles. The efficiency of RPTT-ReID makes it amenable to edge computing applications. The proposed algorithmic approach resolves shortfalls with current tracking algorithms, specifically challenges in maintaining tracking when subjects cross paths, switch identity, or are occluded in a frame of view. We demonstrate the power of our approach both in single and multi-UAV scenarios to track movable targets by extracting the facial embedding information in crowds, in order to ensure the privacy of individuals captured by the UAVs without compromising the capability for target re-identification. We validate RPTT-ReID on a challenging video dataset of crowded scenes. Our experimental evaluation shows that the proposed approach is capable of tracking and re-identifying people in crowds despite blended trajectories with minimum and maximum accuracy of 79.91 ± 0.2% and 93.27 ± 0.1% respectively. The proposed approach is 18% faster than previous methods for tracking in crowded urban environments.

Computational fluid dynamics was used to study the evolution of small patches of vegetation into a vegetated landscape in a channel. The growth of new vegetation occurred in regions where the flow velocity was reduced below a threshold value defined as a fraction of the channel-average velocity (U0). Two threshold values, or limiting velocity values (LV), were used: LV = 0.5 and 0.7. Two initial blockage factors (percentage vegetation coverage of the channel) were considered, 3% and 0.3%, chosen to represent cases with and without, respectively, hydrodynamic interaction between the initial patches. The simulation illustrated both positive feedbacks between flow and vegetation, which enhanced vegetation expansion, and negative feedbacks, which led to patch erosion and limited patch growth. The most rapid expansion of the vegetated area occurred during the initial simulation steps, when the flow blockage due to vegetation was small. A higher velocity threshold (higher LV) produced more rapid initial growth and a higher final coverage of vegetation. The patches evolved to one or a few elongated islands extending along the channel.

A autenticação biométrica por meio da dinâmica da digitação, oferece uma segurança a mais para os sistemas, se associando ao tradicional login e senha, pois associa autenticação com fatores biométricos. Esse trabalho apresenta metodologias para a realização da autenticação biométrica po meio da dinâmica da digitação, utilizando técnicas para a extração de características após capturar o tempo em que se pressionar e soltar as teclas. Os métodos utilizados foram: Classificador baseado na distância de Mahalanobis (classificação e autenticação) e Floresta Aleatória (classificação).

OBJECTIVEThe objective of this study was to describe a new experimental model of hemispherotomy performed on laboratory animals.METHODSTwenty-six male young adult Wistar rats were distributed into two groups (surgery and control). The nonfluorescent anterograde neurotracer biotinylated dextran amine (BDA; 10,000 MW) was microinjected into the motor cortex area (M1) according to The Rat Brain in Stereotaxic Coordinates atlas to identify pathways and fibers disconnected after the experimental hemispherectomy. SPECT tomographic images of 99mTc hexamethylpropyleneamine oxime were obtained to verify perfusion in functioning areas of the disconnected and intact brain. A reproducible and validated surgical procedure is described in detail, including exact measurements and anatomical relationships. An additional 30 rodents (n = 10 rats per group) were divided into naïve, sham, and hemispherotomy groups and underwent the rotarod test.RESULTSCortico-cortical neural pathways were identified crossing the midline and contacting neuronal perikarya in the contralateral brain hemisphere in controls, but not in animals undergoing hemispherotomy. There was an absence of perfusion in the left side of the brain of the animals undergoing hemispherotomy. Motor performance was significantly affected by brain injuries, increasing the number of attempts to maintain balance on the moving cylinder in the rotarod test at 10 and 30 days after the hemispherotomy, with a tendency to minimize the motor performance deficit over time.CONCLUSIONSThe present findings show that the technique reproduced neural disconnection with minimal resection of brain parenchyma in young adult rats, thereby duplicating the hemispherotomy procedures in human patients.