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Axillary strategy decisions have become more complex and controversial in considering minimally traumatic therapy instead of sentinel lymph node biopsy, axillary lymph node dissection or regional nodal irradiation for people with breast cancer. The purpose of this study was to noninvasively predict sentinel lymph node (SLN) and non-sentinel lymph node (NSLN) status based on pre-operative sonographic and clinicopathologic features to determine optimal decisions regarding axillary therapy. In total, 701 patients with breast cancer from two independent centers were retrospectively analyzed. The SLN model (SLNM) for predicting SLN status and the NSLN model (NSLNM) for predicting NSLN status were trained based on a training set using the random-forest algorithm, and their performance was validated using an independent external test set. A receiver operating characteristic curve was drawn to obtain the area under the curve, which was used to assess performance. The area under the curve for the SLNM in the training and test, respectively, was 94.2% and 83.0%, and for the NSLNM, 99.5% and 92.7%. The SLNM and NSLNM accurately predicted that 61.46% (319/519) and 17.53% (91/519), respectively, of our participants were non-metastatic. The overall benefit of the three models was 78.99% in our participants. The two models for predicting SLN and NSLN status showed excellent application potential in optimizing axillary strategies.

In this letter, we perform a first-principles study on the adsorption performance of the InP3 monolayer upon three SF6 decomposed species, including SO2, SOF2, and SO2F2, to investigate its potential as a resistance-type, optical or field-effect transistor gas sensor. Results indicate that the InP3 monolayer exhibits strong chemisorption upon SO2 but weak physisorption upon SO2F2. The most admirable adsorption behavior is upon SOF2, which provides a favorable sensing response (-19.4%) and recovery property (10.4 s) at room temperature as a resistance-type gas sensor. A high response of 180.7% upon SO2 and a poor one of -1.9% upon SO2F2 are also identified, which reveals the feasibility of the InP3 monolayer as a resistance-type sensor for SO2 detection with recycle use via a heating technique to clean the surface. Moreover, the InP3 monolayer is a promising optical sensor for SO2 detection due to the obvious changes in adsorption peaks within the range of ultraviolet and is a desirable field-effect transistor sensor for selective and sensitive detection of SO2 and SOF2 given the evident changes of QT and Eg under the applied electric field.

This letter reports the avalanche and surge current ruggedness of the industry's first 1.2-kV-class vertical GaN p-n diodes fabricated on 100-mm GaN substrates. The 1.2-kV vertical GaN p-n diodes with a 1.39-mm2 device area and an avalanche breakdown voltage of 1589 V show a critical avalanche energy density of 7.6 J/cm2 in unclamped inductive switching tests, as well as a critical surge current of 54 A and a critical surge energy density of 180 J/cm2 in 10-ms surge current tests. All these values are the highest reported in vertical GaN devices and comparable to those of commercial SiC p-n diodes and merged p-n Schottky diodes. These GaN p-n diodes show significantly smaller reverse recovery compared to SiC p-n diodes, revealing less conductivity modulation in n-GaN. The negative temperature coefficient of differential on-resistance and the anticlockwise surge I–V locus are believed to be due to the increased acceptor ionization in p-GaN and the decreased contact resistance at high temperatures. These results suggest a high ruggedness of GaN p-n junctions with small bipolar currents and fast switching capabilities. As the first electrothermal ruggedness data for industry's vertical GaN devices, these results provide key new insights for the development of vertical GaN devices as well as their application spaces.

Objective To investigate the effect and mechanism of Glucocorticoids (GCs) induced oxidative stress and apoptosis on necrosis of the femoral head in patients and rats. Methods Eight patients with steroid‐induced avascular necrosis of the femoral head (SINFH) and eight patients with developmental dysplasia of the hips (DDH) were enrolled in our study. In animal model, twenty male Sprague‐Dawley rats were randomly divided into two groups (SINFH group and NS group). The SINFH model group received the methylprednisolone (MPS) injection, while control group was injected with normal saline (NS). MRI was used to confirm SINFH rat model was established successfully. Then, the rats were sacrificed 4 weeks later and femoral head samples were harvested. Histopathological staining was preformed to evaluate osteonecrosis. TUNEL staining was performed with 8‐OHdG and DAPI immunofluorescence staining to evaluate oxidative injury and osteocyte apoptosis. Immunohistochemistry staining was used to detect Nox1, Nox2, and Nox4 protein expression. Results MRI showed signs of typical osteonecrosis of femoral head in SIHFH patients. Histopathological staining showed that the rate of empty lacunae in SINFH patients was significantly higher (56.88% ± 9.72% vs 19.92% ± 4.18%, T = −11.04, P, Steroid‐induced avascular necrosis of the femoral head (SINFH) induction protocol. MPS, methylprednisolone; NS, normal saline.

The poor response time and incomplete recovery of MoS2 sensor at room temperature (RT) have been a serious issue to obstruct its widely sensing applications. In present work, we comprehensively studied three methods: rising temperature, building field-effect transistors (FETs), and adding light illumination to improve the performance of the device. The related sensing mechanism of the three processes was also analyzed. The high response rate up to 2510%, low theoretical concentration detection limit down to 693 ppb, and excellent recovery at RT to NO2 were achieved for the MoS2 FET sensor with the aid of light illumination. This significant improvement in sensing performances is mainly attributed to the activated sensing layer by phonon energy transfer and enhanced population of the charge carrier raised from optical energy. Schottky barrier modulation was also an important factor to impact sensing performance. Furthermore, the MoS2 nanosheets exhibit good photosensing characteristics such as rapid photon response, high light-induced photocurrent, and so on. It has been demonstrated that the light illuminated FET configuration can effectively accelerate response time and promote recovery rate of MoS2-based sensor operating at RT, which provides a strategy to design an optoelectronic device with optimal sensing properties.

Adversarial examples can easily fool existing powerful deep neural networks. However, we find that the attack ability of most existing adversarial attack methods is significantly degraded once the generated adversarial examples are shown on screen devices and are further captured. This is mainly attributed to two challenges: (1) Extra noises and variance during the capturing process, such as lens distortion and diverse capturing angle. (2) They get stuck in a self-contradictory problem between visual quality and attack ability. Inspired by the properties of the human visual system (HVS), this paper dedicatedly designs the first color decomposition-based adversarial example method CDAE for screen devices. Specifically, it decomposes one regular screen frame into two symmetric adversarial frames with maximum modifications while theoretically guaranteeing the visual quality perceived by human observers. Thanks to the powerful generalization ability of the proposed method, we can combine it with most adversarial example generation methods and achieve state-of-the-art attack ability. Additionally, it can also be used to protect important information from leakage and attack existing video action recognition networks .

In this article, a new procedure is proposed on the basis of Hilbert-Huang Transform and deep learning for cyber-attacks detection in direct current (DC) micro-grids (MGs) as well as detection of the attacks in distributed generation (DG) units and its sensors. An advanced elective group deep learning method with Krill Herd Optimization (KHO) algorithm is proposed. At first, Hilbert-Huang Transform is used with the aim of extracting the signals feature and next these features are applied as the multiple deep input basis models are made with the aim of capturing automatically sentient traits from raw fluctuation signals. At third, to make sure the variety of the basis patterns, linear decoder, denoising autoencoder and sparse autoencoder are applied to make various deep autoencoders, respectively. Further, Bootstrap is applied with the aim of designing separate educational data subsets for any base model. Fourth, for implementing selective ensemble learning, a combination strategy of enhanced weighted voting (EWV) with class-particular thresholds is studied. Eventually, KHO algorithm is applied with the aim of adaptive selecting the optimal class-specific thresholds. In the offered tactic, firstly, a DC micro-grid is functioned and controlled with the lack of any false data injection attacks (FDIAs) to collect adequate information within the usual operation needed for the educating of deep learning networks. It is noteworthy that, in the procedure of datum production, load variable is also determined with the aim of having distinctive datasets for cyber-attack scenarios and load variables. Also, to provide more realistic method, the smart plug-in electric vehicle is also considered in the model. Outcomes of Simulation in various scenarios are applied with the aim of verifying the benefit of the offered procedure. The outcomes propose that the offered procedure is able to more accurate and robust know various type of false data injection attack over than 93.76% accuracy detection of true rate.

Most patients that resuscitate successfully from cardiac arrest (CA) suffer from poor neurological prognosis. DL-3-n-butylphthalide (NBP) is known to have neuroprotective effects via multiple mechanisms. This study aimed to investigate whether NBP can decrease neurological impairment after CA. We studied the protective role of NBP in the hippocampus of a rat model of cardiac arrest induced by asphyxia. Thirty-nine rats were divided randomly into sham, control, and NBP groups. Rats in control and NBP groups underwent cardiopulmonary resuscitation (CPR) 6 min after asphyxia. NBP or vehicle (saline) was administered intravenously 10 min after the return of spontaneous circulation (ROSC). Ultrastructure of hippocampal neurons was observed under transmission electron microscope. NBP treatment improved neurological function up to 72 h after CA. The ultrastructural lesion in mitochondria recovered in the NBP-treated CA model. In conclusion, our study demonstrated multiple therapeutic benefits of NBP after CA.

Optical satellites are affected by factors such as seasonal and atmospheric variation, illumination, and sensor distortion. Thus, satellite images covering large-scale area often show conspicuous color differences, resulting in poor color continuity of the mosaicked satellite image. This study proposes a novel combined model color correction (CMCC) method for high-resolution optical satellite images, which constructively combines a defogging model with a radiation correction model. First, this study analyzed the feasibility of using easily available low-resolution satellite images as external references to correct the color of high-resolution images and describes the selection criteria for external references. Second, considering the negative effects of atmosphere on the color and clarity of remote sensing images, we proposed an optical satellite image enhancement method, which is based on the content characteristics of remote sensing images and the dark channel prior defogging method. Finally, we designed a two-stage color correction process: 1) correcting the color of downsampled images via low-frequency modeling and replacement and 2) mapping the color of downsampled images to original images through local modeling and super-resolution color correction. Furthermore, this study proposes an indicator of quality considered mean absolute error (QCMAE) for quantitative evaluation of the color correction result. We selected 328 Gaofen-1 (GF-1) high-resolution images for the experiments. Visual effects and statistical results of images after being processed by the proposed CMCC are both superior to the three state-of-the-art methods, which verifies the effectiveness and reliability of the proposed method.

Shengwei Wang,1 Hao Cui,2 Keshan Ji,3 Changsheng Zhu,4 Xiaohong Huang,3 Yongqiang Lai,1 Shuiyun Wang4 1Cardiovascular Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vascular Diseases, Beijing, People’s Republic of China; 2Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, USA; 3Special Medical Treatment Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 4Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Yongqiang LaiCardiovascular Surgery Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vascular Diseases, No. 2, Anzhen Road, Chaoyang District, Beijing, 100029, People’s Republic of ChinaEmail yongqianglai@yahoo.comShuiyun WangDepartment of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Xicheng District, Beijing, 100037, People’s Republic of ChinaEmail wsymd@sina.comPurpose: Obstructive sleep apnea (OSA) and myocardial fibrosis are associated with cardiac arrhythmia. The purpose of this study was to explore the relationship between OSA and myocardial fibrosis, as well as their impact on cardiac arrhythmia in hypertrophic obstructive cardiomyopathy (HOCM) patients.Methods: We prospectively studied 151 consecutive patients with a confirmed diagnosis of HOCM at the Fuwai Hospital between September 2017 and 2018. Polysomnography, Holter electrocardiography, and cardiac magnetic resonance imaging were performed on all patients. Myocardial fibrosis was reflected by late gadolinium enhancement (LGE), detected using cardiac magnetic resonance imaging.Results: Myocardial fibrosis, measured using LGE%, was found to increase with increasing OSA severity [6.8% (3.6– 12.9%), 6.1% (3.4– 10.0%), 9.6% (5.5– 14.5%), and 15.5% (9.3– 20.0%) for no-OSA, mild OSA, moderate OSA, and severe OSA, respectively; p=0.003]. LGE% correlated with the New York Heart Association functional classifications (p=0.018), septal thickness (p=0.026), and apnea-hypopnea index (AHI) (p< 0.001). The prevalence of isolated premature ventricular contraction (PVC) (p=0.028), paired PVC (p=0.036), ventricular bigeminy (p=0.005)/trigeminy (p< 0.001), non-sustained ventricular tachycardia (NSVT) (p=0.001), isolated premature atrial contraction (PAC) (p=0.032), and supraventricular tachycardia (p=0.029) was significantly higher in patients with OSA. Additionally, LGE% and AHI were independent risk factors for isolated PVC (OR: 1.04, p=0.001 and OR: 1.07, p=0.039, respectively), ventricular bigeminy (OR: 1.04, p=0.003 and OR: 1.26, p=0.002, respectively)/trigeminy (OR: 1.07, p=0.040 and OR: 1.06, p=0.001, respectively), and NSVT (OR: 1.17, p< 0.001 and OR: 1.08, p< 0.001, respectively) after adjustment for age, sex, and other parameters.Conclusion: Both OSA and LGE% were associated with a greater likelihood and increased frequency of ventricular arrhythmias (including NSVT) in patients with HOCM. Thus, the severity of OSA was independently associated with more severe myocardial fibrosis in patients with HOCM.Keywords: hypertrophic obstructive cardiomyopathy, obstructive sleep apnea, cardiac arrhythmia

AIM: To determine the etiologies, treatment modalities and visual outcomes of vitreous hemorrhage (VH; range from birth to 18y). METHODS: A total of 262 eyes from 210 patients between January 2010 and September 2016 were included. All children underwent an appropriate ocular and systemic examination. Data collected included demographics, clinical manifestations, details of the ocular and systemic examination, management details, final fundus anatomy and visual acuity (VA). RESULTS: The most common etiologies were non-traumatic VH (64.89%), most of which were due to retinopathy of prematurity (ROP; 37.10%); while traffic accidents, including 16 (21.00%) eyes, was the most common ocular traumas. Surgery, performed in 143 (54.58%) eyes, was the most common management modality. The initial mean baseline visual acuity was 2.77±0.21 logarithm of the minimal angle of resolution (logMAR) in children and adolescent with traumatic VH, which was significantly improved to 2.15±1.31 logMAR (P

Background Although surgical treatment of residual obstruction after alcohol septal ablation (ASA) is often challenging in patients with obstructive hypertrophic cardiomyopathy (OHCM) there are very few relevant clinical reports. Thus, outcomes of surgical septal myectomy (SSM) in this subgroup of patients remain to be determined. Therefore, this study aimed to determine the surgical and follow-up outcomes in patients with OHCM exhibiting residual obstruction after ASA. Methods We collected case data for 62 patients with OHCM and residual obstruction after ASA who underwent SSM at Fuwai Hospital between January 2002 and June 2019. Propensity score matching with patients having had a myectomy as the only invasive procedure-was conducted in a 1:2 ratio. Echocardiography parameters, surgery results, and follow-up outcomes were compared between the groups. Results The prior ASA group had a higher incidence of complete atrioventricular block (AVB) and subsequently postoperative permanent pacemaker (PPM) implantation than the primary myectomy group (9.7% vs. 1.6%, P=0.01). Two patients died within 30 days after surgery in the prior ASA group, and one patient died in the primary myectomy group, with an operative mortality rate of 3.2% and 0.8%, respectively (P=0.2). The 5-year event-free survival rate was 86.0% in the prior ASA group (median follow-up period: 3.2 years; mean: 3.9±2.6 years; maximum, 10.6 years) and 88.5% in the primary myectomy group (median follow-up period: 2.4 years; mean 2.8±1.7 years; maximum, 9.1 years) (P=0.2). During follow-up, four of 62 (6.5%) patients in the prior ASA group and one of 124 (0.8%) patients in the primary myectomy group progressed to advanced heart failure (P=0.025). Conclusions Patients with OHCM following ASA are at an increased risk of developing AVB after SSM. Their surgical outcomes, and long-term survival rate were satisfactory and, osimilar to those for patients having had a myectomy as the only invasive procedure. In addition, they had an increased risk of advanced heart failure after SSM in the present study.

BACKGROUND Myocardial bridging (MB) is commonly treated in patients with hypertrophic cardiomyopathy. However, whether and how MB should be treated in patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent septal myectomy remain unclear. METHODS A total of 823 adults with HOCM who underwent septal myectomy at the Fuwai Hospital from 2011 to 2017 were retrospectively studied. RESULTS Overall, 31 events occurred: 24 patients died and 7 had nonfatal myocardial infarction (MI). The 3-year cumulative event-free survival of all-cause death (97.9% vs. 100% vs. 100% vs. 98.4%, p = .89) and cardiovascular death (98.3% vs. 100% vs. 100% vs. 98.4%, p = .63) were similar among the four groups (non-MB, coronary artery bypass grafting [CABG], unroofing, untreated, respectively). However, the 3-year cumulative event-free survival of nonfatal MI (100% vs. 97.5% vs. 98.0% vs. 89.9%, p

The Editors of Tissue Engineering: Part A retract the article entitled, "Cell Fate and Tissue Remodeling in Canine Urethral Repair Using a Bone Marrow Mesenchymal Stem Cell+Endothelial Progenitor Cell Amniotic Patch," by Wenxin Zhang, Xin Zhang, Yihua Zhang, Xinke Zhang, Tong Zou, Wen Zhao, Yangou Lv, Jinglu Wang, Pengxiu Dai, Hao Cui, Yi Zhang, Dengke Gao, Chenmei Ruan, and Xia Zhang (epub ahead of print September 21, 2020; DOI: http://doi.org/10.1089/ten.tea.2020.0129). After the online publication of the article, the authors have indicated that they "feel that we have not yet studied our work completely and some new great results are discovered. So after carefully thinking, we are going to rearrange this manuscript and try to give more precise model. [sic]" The authors have not explained what those expected results will be, so it remains unclear the direction their work is headed. The authors also indicated that they plan to submit an updated version of the paper to Tissue Engineering in the future. Upon submission the new manuscript will undergo rigorous peer review, and there is no guarantee of acceptance.

This paper designs a novel underpainting based camera shooting resilient (CSR) document watermarking algorithm for dealing with the leak source tracking problem. By applying such algorithm, we can extract the authentication watermark information from the candid photographs. The watermarked underpainting contains three significant properties. 1) Inconspicuousness. The watermarked underpainting is inconspicuous and it will not easily be maliciously attacked. 2) Robustness. We propose DCT-based watermark embedding algorithm and distortion compensation based extracting algorithm, which make the watermark robust to camera shooting process. 3) Autocorrelation. We design the flip-based method to arrange the watermarked underpainting. So that a complete watermark region can be accurately located even if part of the document is recorded. Compared with previous watermarking algorithms, the proposed scheme guaranteed content independent embedding as well as the robustness to the camera shooting process. Besides, the proposed scheme satisfies the accuracy of extraction even when the captured document is incomplete.

Large-scale deployment of photovoltaic (PV) modules has considerably increased in recent decades. Given an estimated lifetime of 30 years, the challenge of how to handle large volumes of end-of-life PV modules is starting to emerge. In this Perspective, we assess the global status of practice and knowledge for end-of-life management for crystalline silicon PV modules. We focus in particular on module recycling, a key aspect in the circular economy of photovoltaic panels. We recommend research and development to reduce recycling costs and environmental impacts compared to disposal while maximizing material recovery. We suggest that the recovery of high-value silicon is more advantageous than the recovery of intact silicon wafers. This approach requires the identification of contaminants and the design of purification processes for recovered silicon. The environmental and economic impacts of recycling practices should be explored with techno–economic analyses and life-cycle assessments to optimize solutions and minimize trade-offs. As photovoltaic technology advances rapidly, it is important for the recycling industry to plan adaptable recycling infrastructure. The increasing deployment of photovoltaic modules poses the challenge of waste management. Heath et al. review the status of end-of of-life management of silicon solar modules and recommend research and development priorities to facilitate material recovery and recycling of solar modules.

Objective To describe the characteristics and outcomes of patients with severe COVID-19 and in-hospital cardiac arrest (IHCA) in Wuhan, China. Methods The outcomes of patients with severe COVID-19 pneumonia after IHCA over a 40-day period were retrospectively evaluated. Between January 15 and February 25, 2020, data for all cardiopulmonary resuscitation (CPR) attempts for IHCA that occurred in a tertiary teaching hospital in Wuhan, China were collected according to the Utstein style. The primary outcome was restoration of spontaneous circulation (ROSC), and the secondary outcomes were 30-day survival, and neurological outcome. Results Data from 136 patients showed 119 (87.5%) patients had a respiratory cause for their cardiac arrest, and 113 (83.1%) were resuscitated in a general ward. The initial rhythm was asystole in 89.7%, pulseless electrical activity (PEA) in 4.4%, and shockable in 5.9%. Most patients with IHCA were monitored (93.4%) and in most resuscitation (89%) was initiated Conclusion Survival of patients with severe COVID-19 pneumonia who had an in-hospital cardiac arrest was poor in Wuhan.

OBJECTIVE The optimal effective temperature of targeted temperature management (TTM) used to prevent cerebral injury following cardiopulmonary resuscitation (CPR) is undetermined. In this study, we compared the mortality, neurologic deficits, and cerebral protein levels of two target temperatures. METHODS Fifty 4-month-old female domestic pigs were randomized to sham, TTM at 33°C ± 0.5°C (T33), TTM at 35°C ± 0.5°C (T35), and normothermic (NT) groups. In the NT and TTM groups, untreated ventricular fibrillation was induced electrically in animals for 10 min, followed by 6 min of CPR. Target core temperatures (Tc) of TTM groups were induced and maintained (6 h) using an endovascular hypothermia device, and rewarmed to 37.5 ± 0.5°C in the next 6 h. Tc of the NT group was maintained at 37.5 ± 0.5°C. The survival outcomes and neurological function were evaluated every 24 h for 72 h. RESULTS All animals were successfully resuscitated with no significant differences in baseline characteristics or hemodynamic indexes. Survival rates and neurological outcomes were significantly improved in the TTM groups, with T33 showing the most significant effect. Compared with NT-treated animals, TTM-treated animals had higher expressions of angiopoietin-1, transforming growth factor-alpha , vascular endothelial growth factor, metallopeptidase inhibitor (TIMP)-1, TIMP-2, and platelet-derived growth factor-BB. Macrophage migration inhibitory factor and IL-17F levels were markedly upregulated after resuscitation in the NT group but inhibited in the TTM groups. Neuron-specific enolase staining data was also consistent with our conclusion that hypothermia can reduce reperfusion-induced brain injuries. CONCLUSION Lower target temperature showed greater protective effects against cerebral injuries after CPR, and the improved neurological outcomes after TTM may be associated with decreased expression of pro-inflammatory cytokines and increased expression of blood-brain barrier and neurogenesis regulatory factors in this porcine model of CA following resuscitation.

Background Type 2 diabetes mellitus is common in cardiovascular disease. It is associated with adverse clinical outcomes for patients who had undergone coronary artery bypass and valve operations. The aim of this study was to evaluate the impact of type 2 diabetes mellitus on the midterm outcomes of patients with hypertrophic cardiomyopathy who underwent septal myectomy. Methods We retrospectively analyzed the data of 67 hypertrophic cardiomyopathy patients with type 2 diabetes mellitus who underwent septal myectomy from two medical centers in China from 2011 to 2018. A propensity score–matched cohort of 134 patients without type 2 diabetes mellitus was also analyzed. Results During a median follow-up of 28.0 (interquartile range: 13.0–3.0) months, 9 patients died. The cause of death of all of these patients was cardiovascular, particularly sudden cardiac death in 3 patients. Patients with type 2 diabetes mellitus had a higher rate of sudden cardiac death (4.5% vs. 0.0%, p = 0.04). The Kaplan–Meier survival analysis revealed that the rates of predicted 3-year survival free from cardiovascular death (98.1% vs. 95.1%, p = 0.14) were similar between the two groups. However, the rates of predicted 3-year survival free from sudden cardiac death (100% vs. 96.7%, p = 0.01) were significantly higher in hypertrophic cardiomyopathy patients without type 2 diabetes mellitus than in those with type 2 diabetes mellitus. Furthermore, after adjustment for age and sex, only N-terminal pro-brain natriuretic peptide (hazards ratio: 1.002, 95% confidence interval: 1.000–1.005, p = 0.02) and glomerular filtration rate ≤ 80 ml/min (hazards ratio: 3.23, 95% confidence interval: 1.34–7.24, p = 0.047) were independent risk factors for hypertrophic cardiomyopathy patients with type 2 diabetes mellitus. Conclusions Hypertrophic cardiomyopathy patients with and without type 2 diabetes mellitus have similar 3-year cardiovascular mortality after septal myectomy. However, type 2 diabetes mellitus is associated with higher sudden cardiac death rate in these patients. In addition, N-terminal pro-brain natriuretic peptide and glomerular filtration rate ≤ 80 ml/min were independent risk factors among hypertrophic cardiomyopathy patients with type 2 diabetes mellitus.

Deep learning has achieved tremendous success in numerous industrial applications. As training a good model often needs massive high-quality data and computation resources, the learned models often have significant business values. However, these valuable deep models are exposed to a huge risk of infringements. For example, if the attacker has the full information of one target model including the network structure and weights, the model can be easily finetuned on new datasets. Even if the attacker can only access the output of the target model, he/she can still train another similar surrogate model by generating a large scale of input-output training pairs. How to protect the intellectual property of deep models is a very important but seriously under-researched problem. There are a few recent attempts at classification network protection only. In this paper, we propose the first model watermarking framework for protecting image processing models. To achieve this goal, we leverage the spatial invisible watermarking mechanism. Specifically, given a black-box target model, a unified and invisible watermark is hidden into its outputs, which can be regarded as a special task-agnostic barrier. In this way, when the attacker trains one surrogate model by using the input-output pairs of the target model, the hidden watermark will be learned and extracted afterward. To enable watermarks from binary bits to high-resolution images, both traditional and deep spatial invisible watermarking mechanism are considered. Experiments demonstrate the robustness of the proposed watermarking mechanism, which can resist surrogate models learned with different network structures and objective functions. Besides deep models, the proposed method is also easy to be extended to protect data and traditional image processing algorithms., Comment: AAAI 2020

Differences in individual drug responses are obstacles in breast cancer (BRCA) treatment, so predicting responses would help to plan treatment strategies. The accumulation of cancer molecular profiling and drug response data provide opportunities and challenges to identify novel molecular signatures and mechanisms of tumor responsiveness to drugs in BRCA. This study evaluated drug responses with a multi-omics integrated system that depended on long non-coding RNAs (lncRNAs). We identified drug response-related lncRNAs (DRlncs) by combining expression data of lncRNA, microRNA, messenger RNA, methylation levels, somatic mutations, and the survival data of cancer patients treated with drugs. We constructed an integrated and computational multi-omics approach to identify DRlncs for diverse chemotherapeutic drugs in BRCA. Some DRlncs were identified with Adriamycin, Cytoxan, Tamoxifen, and all samples for BRCA patients. These DRlncs showed specific features regarding both expression and computational accuracies. The DRlnc-gene co-expression networks were constructed and analyzed. Key DRlncs, such as HOXA-AS2 (Ensembl: ENSG00000253552), in the drug Adriamycin were characterized. The experimental analysis also suggested that HOXA-AS2 (Ensembl: ENSG00000253552) was a key DRlnc in Adriamycin drug resistance in BRCA patients. Some DRlncs were associated with survival and some specific functions. A possible mechanism of DRlnc HOXA-AS2 (Ensembl: ENSG00000253552) in the Adriamycin drug response for BRCA resistance was inferred. In summary, this study provides a framework for lncRNA-based evaluation of clinical drug responses in BRCA. Understanding the underlying molecular mechanisms of drug responses will facilitate improved responses to chemotherapy and outcomes of BRCA treatment.

The existing deep learning methods for human fall detection have difficulties to distinguish falls from similar daily activities such as lying down because of not using the 3D network. Meanwhile, they are not suitable for mobile devices because they are heavyweight methods and consume a large number of memories. In order to alleviate these problems, a two-stream approach to fall detection with the MobileVGG is proposed in this paper. One stream is based on the motion characteristics of the human body for detection of falls, while the other is an improved lightweight VGG network, named the MobileVGG, put forward in the paper. The MobileVGG is constructed as a lightweight network model through replacing the traditional convolution with a simplified and efficient combination of point convolution, depth convolution and point convolution. The residual connection between layers is designed to overcome the gradient disappeared and the obstruction of gradient reflux in the deep model. The experimental results show that the proposed two-stream lightweight fall classification model outperforms the existing methods in distinguishing falls from similar daily activities such as lying and reducing the occupied memory. Therefore, it is suitable for mobile devices.

Efficient semantic segmentation of large-scale 3D point clouds is a fundamental and essential capability for real-time intelligent systems, such as autonomous driving and augmented reality. The high dimension feature vector and the complex network structure are two major constraints to utilize the large-scale point cloud. This paper proposes an optimal feature description vector network (OFDV-Net) for 3D point cloud semantic segmentation. First, a multiscale point cloud feature extraction structure is constructed to generate an initial feature description vector (IFDV). Then, IFDV is selected by a feature selection unit to obtain the optimal feature description vector (OFDV). The OFDV encapsulates the best 3D features set of the points and can be used as the input of the deep neural network for training and testing. Finally, the OFDV-Net was applied to the standard public outdoor large-scale point cloud datasets Semantic3D and NPM3D, and the overall segmentation accuracy of 88.3% and 87.7% were obtained, respectively; moreover, the OFDV-Net requires less training time, which indicates that the algorithm can obtain high-precision semantic segmentation results on an outdoor large-scale point cloud while reducing model training time.

Objectives: This study aims to investigate the risk factors of in-hospital postoperative atrial fibrillation (POAF) and the impact of POAF on the clinical outcome in hypertrophic cardiomyopathy (HCM) patients who underwent myectomy. Methods: Data from a total of 494 obstructive HCM patients, who had undergone preoperative cardiac magnetic resonance (CMR) testing and who underwent myectomy at Fuwai Hospital from June 2011 to June 2016, were collected. Results: Multivariate logistic regression analysis showed that old age (odds ratio [OR], 4.326; 95% confidence interval [CI], 2.248–8.325; p

This investigation analyzed clinical characteristics of patients with hypertrophic cardiomyopathy (HCM) and latent left ventricular outflow tract (LVOT) and outcomes following septal myectomy.We reviewed patients with HCM and LVOT obstruction undergoing septal myectomy from 2001 to 2016 at our center. Follow-up data on functional status were obtained through mailed survey questionnaires.There were 629 (31.8%) patients with latent obstruction (resting LVOT gradientlt;30 mm Hg, provoked gradientgt;30 mm Hg) among 1981 patients undergoing septal myectomy. Patients with latent obstruction were more likely to be male (65.7% vs 51.8%, P lt; .001), but there were no important differences in other clinical characteristics. The New York Heart Association functional classes and measured/predicted maximal oxygen consumption (62 [51, 72] vs 60 [48, 72], P = .158) in cardiopulmonary exercise tests were comparable between the 2 groups. Patients with latent obstruction had both lower septal thickness and lower posterior wall thickness. Median intraoperative provoked pressure gradient decreased from 96 (68, 126) mm Hg to 0 (0, 6) mm Hg after myectomy (P lt; .001). There was no difference in early (lt;30 days) deaths (3/629 vs 5/1352, P = .726) and long-term survival between patients with latent obstruction and resting obstruction. In follow-up, both general health status and New York Heart Association functional class were significantly improved following septal myectomy.Patients with HCM and latent LVOT obstruction generally have milder left ventricular hypertrophy but similarly impaired functional capacity compared to those with resting obstruction. Septal myectomy improves functional capacity and symptoms.

In this paper a method of research for the reliability of solder joint shapes is proposed. By using Surface Evolver software, finite element analysis, minimum energy principle and gradient descent method to calculate the minimum state of energy, the final shape of the solder joint is predicted. By studying the shape of SOP solder joints and using Surface Evolver software, the error between model parameters and slice parameters is finally less than ±10%, which reduces the error between device models and slices. The reliability and life of solder joints are more accurately predicted.

A Special Issue of Metals was commissioned that was devoted to aspects of Mineral Processing and Hydrometallurgy [...]

Objective This study was conducted to determine the influence of early septal reduction therapy (SRT) after referral on survival in patients with obstructive hypertrophic cardiomyopathy. Methods We reviewed the patients with obstructive hypertrophic cardiomyopathy (resting pressure gradient ≥30 mm Hg or provoked pressure gradient ≥50 mm Hg) who were evaluated at our clinic from 2000 to 2012. Early SRT was defined as undergoing septal myectomy or alcohol septal ablation during the 6 months after index evaluation. Survival after the 6-month landmark period was analyzed in a multivariable Cox model. Results A total of 1351 patients were included in the landmark analysis. Patients who were more symptomatic and had received more medical treatment at index evaluation were more likely to undergo early SRT. Over a median follow-up period of 10.2 years, the survival was comparable (P = .207) but patients undergoing early SRT had, on average, improved survival compared with the medical treatment group (hazard ratio, 0.66; 95% confidence interval, 0.48-0.90) after adjustment by age and comorbidities. Further analysis revealed significant treatment heterogeneity, with increased benefit of early SRT seen in women (hazard ratio, 0.51; 95% confidence interval, 0.35-0.75), those who are in New York Heart Association functional class III or IV (hazard ratio, 0.52; 95% confidence interval, 0.36-0.76), and patients without diabetes (hazard ratio, 0.59; 95% confidence interval, 0.42-0.82). Conclusions In experienced hypertrophic cardiomyopathy centers, early SRT is similar to continued medical treatment for patients with obstructive hypertrophic cardiomyopathy. It appears to improve survival of female patients and those who are in New York Heart Association functional class III or IV.

BACKGROUND At present, some cancer patients experience hyperprogressive disease (HPD) after receiving immunotherapy. This study used the Response Evaluation Criteria in Solid Tumors 1.1 to evaluate the incidence of HPD in patients receiving immune checkpoint inhibitors (ICIs) for treating primary liver cancer (PLC) and to explore the risk factors for HPD. METHODS This retrospective, single-center study included patients with PLC who were treated with ICIs. The RECIST 1.1 was used to determine patients with HPD. Univariate and multivariate regression analyses were performed to explore the risk factors for HPD, and clinical variables with prognostic significance for HPD were included to establish a risk model. RESULTS Among 129 patients with PLC treated with ICIs, HPD occurred in 13 patients (10.1%). In the multivariate regression analysis, lymph node metastasis and lung metastasis were risk factors for HPD. The area under the curve of the risk model, established by including lymph node metastasis, lung metastasis, neutrophil-lymphocyte ratio, albumin, and performance status, was 0.801 (P

Objective The objective of this study was to determine the characteristics of longitudinal strain and its effect on outcomes in patients with obstructive hypertrophic cardiomyopathy (HCM) who underwent septal myectomy. Methods We reviewed patients with obstructive HCM who underwent septal myectomy at our clinic from 2007 to 2016. Data of those who had strain echocardiography within 6 months before isolated myectomy were analyzed. Results The median age of the 857 patients studied was 55 (interquartile range [IQR], 44-63) years, and 451 (52.6%) were male. Left ventricular ejection fraction was 71% (IQR, 67%-74%), and the resting peak outflow tract gradient was 58 (IQR, 27-85) mm Hg. The median global longitudinal strain (GLS) was −14.6% (IQR, −12.0% to −17.3%). Regional longitudinal strain was nonuniform as reflected by more normal values in apical segments and more abnormal in basal segments. Moreover, GLS correlated poorly with ejection fraction and outflow tract gradient. In 64 patients who had postoperative strain echocardiography, GLS was comparable before and after septal myectomy, but regional strain was more uniform after myectomy. Over a follow-up of 8.3 (IQR, 6.5-10.3) years, when patients were equally stratified according to GLS (cutoff, −14.64%), the group with worse GLS had significantly poorer survival compared with the better GLS group (P = .002). Left ventricular ejection fraction had no association with survival. Conclusions Left ventricular longitudinal strain is nonuniform and might be significantly reduced in patients with obstructive HCM. Septal myectomy does not impair GLS but is associated with more uniform regional strains. Most importantly, reduced GLS preoperatively is strongly and independently associated with increased all-cause mortality after septal myectomy for obstructive HCM.

Background Phosphoglucomutase 1 (PGM1) acts as an important regulator in glucose metabolism. However, the role of PGM1 in gastric cancer (GC) remains unclear. This study aims to investigate the role of PGM1 and develop novel regimens based on metabolic reprogramming in GC. MethodsCorrelation and enrichment analysis of PGM1 was conducted based on The Cancer Genome Atlas database. Data derived from the Kaplan-Meier Plotter database were analyzed for correlations between PGM1 expression and survival time of GC patients. CCK-8, EdU, flow cytometry assays, generation of subcutaneous tumor and lung metastasis mouse models were used to determine growth and metastasis in vitro and in vivo. Cell glycolysis was detected by a battery of glycolytic indicators, including lactate, pyruvic acid, ATP production and glucose uptake. Fatty Acid Synthase (FASN) activity and detection of lipid regulators levels by western blot were used to reflect on the cell lipid metabolism. ResultsCorrelation and enrichment analysis suggested that PGM1 was closely associated with cell proliferation and metabolism. PGM1 was overexpressed in GC tissues and cell lines. High PGM1 expression served as an indicator of shorter survival for specific subpopulation of GC patients, which was also correlated with some clinicopathological features, including T stage and TNM stage. Under low glucose conditions, knockdown of PGM1 significantly suppressed cell proliferation and glycolysis levels, whereas lipid metabolism was enhanced. Orlistat, as a drug that was designed to inhibit FASN activity for obesity treatment, effectively induced apoptosis, suppressed FASN activity. However, orlistat conversely increased glycolytic levels in GC cells. Orlistat exhibited more significant inhibitive effects on GC progression after knockdown of PGM1 under glucose deprivation due to combination of glycolysis and lipid metabolism. ConclusionsDownregulation of PGM1 expression under glucose deprivation synergistically enhanced anti-cancer effects of orlistat. This combination application may serve as a novel strategy for GC treatment.

Background and AimsPrediction of pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) for breast cancer is critical for surgical planning and evaluation of NAC efficacy. The purpose of this project was to assess the efficiency of a novel nomogram based on ultrasound and clinicopathological features for predicting pCR after NAC.MethodsThis retrospective study included 282 patients with advanced breast cancer treated with NAC from two centers. Patients received breast ultrasound before NAC and after two cycles of NAC; and the ultrasound, clinicopathological features and feature changes after two cycles of NAC were recorded. A multivariate logistic regression model was combined with bootstrapping screened for informative features associated with pCR. Then, we constructed two nomograms: an initial-baseline nomogram and a two-cycle response nomogram. Sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were analyzed. The C-index was used to evaluate predictive accuracy.ResultsSixty (60/282, 21.28%) patients achieved pCR. Triple-negative breast cancer (TNBC) and HER2-amplified types were more likely to obtain pCR. Size shrinkage, posterior acoustic pattern, and elasticity score were identified as independent factors by multivariate logistic regression. In the validation cohort, the two-cycle response nomogram showed better discrimination than the initial-baseline nomogram, with the C-index reaching 0.79. The sensitivity, specificity, and NPV of the two-cycle response nomogram were 0.77, 0.77, and 0.92, respectively.ConclusionThe two-cycle response nomogram exhibited satisfactory efficiency, which means that the nomogram was a reliable method to predict pCR after NAC. Size shrinkage after two cycles of NAC was an important in dependent factor in predicting pCR.

The present study compared the clinical functional outcomes and new vertebral compression fractures (NVCFs) between percutaneous vertebroplasty (PVP) and conservative treatment (CT) in patients with severe pain due to acute osteoporotic vertebral compression fractures (OVCFs). PVP has been increasingly used for the treatment of pain in patients with OVCFs. However, the effectiveness of the procedure and whether it causes NVCFs has remained controversial.A total of 544 eligible patients with OVCFs found on spinal radiographs and intractable back pain for ≤6 weeks were recruited from September 2012 to February 2018 and assigned to PVP (n = 280; 392 levels) or CT (n = 264; 366 levels). The visual analog scale and Oswestry Disability Index scores were determined before the intervention and at the 1-week and 1-, 3-, 6-, 12-, and 24-month follow-up examinations. In addition, monthly telephone follow-up interviews were performed. In the case of a sudden increase in back pain, the patient returned to the hospital for medical and magnetic resonance imaging examinations for NVCF detection.The PVP group had significantly lower visual analog scale and Oswestry Disability Index scores than those for the CT group at 1 week and 1, 3, and 6 months (P0.05). However, the differences after 6 months were not statistically significant (P0.05). Similar numbers of NVCFs (total and adjacent fractures) were found at 24 months in both groups (P0.05).Compared with CT, PVP provided a rapid decrease in pain and an early return to daily life activities, without an increase in the incidence of NVCFs.

Wear and tear are the most common failures of tubes in cross-flow during long time operation of a steam generator due to the fluid induced vibrations. A fluid-elastic approach with high order was developed by coupling the CFD method and the CSD method. In the method, fluid forces were predicted by the CFD method followed by structural response calculations, and data were transferred via fluid-structure interaction interface. The unsteady flow through normal triangular cylinder arrays with one single tube undergoing self-excited oscillations was simulated by the proposed method. Lifts, displacement and velocity of the particular cylinder were obtained followed by calculations of the corresponding frequency spectrums. Results showed that the proposed method can predict the flow induced vibrations with high accuracy. When the natural frequency of the cylinder increased to the dominant frequency of the flow, an abrupt increment of vibrational velocity was observed.

Background Conduction abnormalities including bundle branch block are recognized sequelae following septal myectomy in patients with hypertrophic cardiomyopathy, but their incidence and effect on long-term mortality have not been well studied. Objectives This study was conducted to determine the impact of conduction abnormalities on mortality in patients with obstructive hypertrophic cardiomyopathy following myectomy. Methods The outcomes of 2,482 patients with obstructive hypertrophic cardiomyopathy who underwent transaortic septal myectomy from 1961 to 2016 were analyzed. Pre-operative and early post-operative electrocardiograms were reviewed to determine conduction status. The study endpoint was all-cause mortality. Results Mean age at operation was 54.2 ± 14.6 years, and 1,370 patients (55.2%) were men. Pre-operatively, 2,159 patients (87.0%) had normal conduction, of whom 38.8% developed left bundle branch block, 1.1% developed right bundle branch block (RBBB), and 0.6% had complete heart block (CHB) after myectomy. Among 112 patients with baseline RBBB, 34.8% developed CHB post-operatively. Overall, only 2.3% of patients developed CHB. Over a median follow-up period of 8.6 years, overall mortality differed among post-operative conduction groups after adjustment for age, sex, and concomitant procedures (p = 0.015). Specifically, mortality in those with paced rhythm after myectomy was significantly increased relative to those with normal conduction (hazard ratio: 1.57; 95% confidence interval: 1.15 to 2.14; p = 0.005), although no significant difference was observed in left bundle branch block and RBBB (vs. normal) groups. Conclusions Left bundle branch block is a common sequela after septal myectomy but does not influence post-operative mortality. Myectomy-related CHB is rare in patients with baseline normal conduction, while pre-existing RBBB greatly increases the risk for CHB. Persistent paced rhythm after operation is an independent predictor of mortality.

Background: Identification of Enzyme Commission (EC) number of enzymes is quite important for understanding the metabolic processes that produce enough energy to sustain life. Previous studies mainly focused on predicting six main functional classes or sub-functional classes, i.e., the first two digits of the EC number. Objective: In this study, a binary classifier was proposed to identify the full EC number (four digits) of enzymes. Methods: Enzymes and their known EC numbers were paired as positive samples and negative samples were randomly produced that were as many as positive samples. The associations between any two samples were evaluated by integrating the linkages between enzymes and EC numbers. The classic machining learning algorithm, Support Vector Machine (SVM), was adopted as the prediction engine. Results: The five-fold cross-validation test on five datasets indicated that the overall accuracy, Matthews correlation coefficient and F1-measure were about 0.786, 0.576 and 0.771, respectively, suggesting the utility of the proposed classifier. In addition, the effectiveness of the classifier was elaborated by comparing it with other classifiers that were based on other classic machine learning algorithms. Conclusion: The proposed classifier was quite effective for prediction of EC number of enzymes and was specially designed for dealing with the problem addressed in this study by testing it on five datasets containing randomly produced samples.

This paper proposes a novel screen-shooting resilient watermarking scheme, which means that if the watermarked image is displayed on the screen and the screen information is captured by the camera, we can still extract the watermark message from the captured photo. To realize such demands, we analyzed the special distortions caused by the screen-shooting process, including lens distortion, light source distortion, and moire distortion. To resist the geometric deformation caused by lens distortion, we proposed an intensity-based scale-invariant feature transform (I-SIFT) algorithm which can accurately locate the embedding regions. As for the loss of image details caused by light source distortion and moire distortion, we put forward a small-size template algorithm to repeatedly embed the watermark into different regions, so that at least one complete information region can survive from distortions. At the extraction side, we designed a cross-validation-based extraction algorithm to cope with repeated embedding. The validity and correctness of the extraction method are verified by hypothesis testing. Furthermore, to boost the extraction speed, we proposed a SIFT feature editing algorithm to enhance the intensity of the keypoints, based on which, the extraction accuracy and extraction speed can be greatly improved. The experimental results show that the proposed watermarking scheme achieves high robustness for screen-shooting process. Compared with the previous schemes, our algorithm provides significant improvement in robustness for screen-shooting process and extraction efficiency.

Network coding has received great attention for its ability to dramatically improve the performance of wireless networks. However, there still is a lack of research on how and to which degree the packet size affects the performance of a wireless network with network coding. In this letter, we study the issue of optimal packet size for inter-flow network coding enabled two-hop error-prone wireless networks with the IEEE 802.11. We analyze the network throughput of such networks and then derive the optimal packet size for maximizing the network throughput under various cases. The simulation results validate the accuracy of our analytical results.

Obstructive sleep apnea (OSA) prevalence is high among patients with hypertrophic cardiomyopathy (HCM). OSA can cause increase in carotid intima-media thickness (CIMT) in the general population. However, whether this phenomenon is applicable to patients with HCM is unclear.A total of 130 consecutive patients with a confirmed diagnosis of hypertrophic obstructive cardiomyopathy (HOCM) at Fuwai Hospital between September 2017 and May 2018 were analyzed.72 patients (55.4%) were diagnosed with OSA. Patients with OSA were older. Compared to those in patients without OSA, the left, right, and mean CIMTs were significantly increased in patients with OSA. In the multiple linear regression model, age (β = 0.341, p 0.001), apnea-hypopnea index (AHI) (β = 0.421, p 0.001), and fasting glucose level (β = 0.167, p 0.03) were independently associated with mean CIMT increase (adjusted RIn patients with HOCM, CIMT increased with OSA severity. Age, AHI, and fasting plasma glucose level were independently associated with mean CIMT increase. Moreover, amaurosis, LVEF, and higher mean CIMT were independently associated with unexplained syncope in patients with HOCM.

Purpose Evaluate the correlation between lumbar facet joint tropism, lumbar facet joint degeneration, and intervertebral disc degeneration. Methods Forty-two of facet joints were evaluated histologically and radiologically. Results The correlation between facet joint tropism and histologic, CT, and MRI grading was −0.159 (P = 0.339), 0.025 (P = 0.226) and −0.270 (P = 0.102), respectively. The correlation between facet joint tropism and intervertebral disc MRI grading was 0.346 (P = 0.033), and that between facet joint and intervertebral disc MRI grading was 0.208 (P = 0.210). Conclusions Facet joint tropism was correlated with intervertebral disc degeneration but not with facet joint degeneration.

In proteomics, it is important to detect, analyze, and quantify complex peptide components and differences. The key is to match the elution time peaks (LC peaks) produced by the same peptide in replicate experiments. Warping functions are currently widely used to correct the mean of time shifts among replicates. However, they cannot reduce the ambiguity to distinguish the corresponding peak pairs and the non-corresponding ones because the time shifts are random based on each extracted-ion-chromatogram (XIC). In this paper, besides time feature, isotope distribution pattern similarity is considered. The novelty is that compared with other feature based methods including the isotope feature, the algorithm is not based on the peak profile similarity as usual, but on the isotope distribution similarity. First, the training set of peptides including the corresponding and non-corresponding peak pairs were selected from the MS/MS results. Second, we generated time difference and isotope distribution pattern similarities for each peak pair. Third, Support Vector Machine (SVM) classification was used based on the two features. Finally, the accuracy was measured along with final coverage. We first used a 10-fold cross validation to test the effectiveness of the SVM learning model. The accuracy of correct matching could reach 97%. Second, we evaluated the coverage based on the learning model, which could be from 75% to 91% in different datasets. Thus, this matching algorithm based on time and isotope distribution pattern features could provide a high accuracy and coverage for the corresponding peak identification.

Epithelial to mesenchymal transition (EMT) is a physiological process that assumes a primary role in the induction of cancer metastasis. This results in increased cell renewal, and resistance to cell death and therapies. EMT, therefore, represents an effective strategy for regulating cancerous cell activity. A need for efficacy and low cytotoxicity epithelial to mesenchymal transition modifying drugs has led to the investigational testing of the efficacy of plethora of different groups of phytonutrients. Luteolin is a natural flavonoid inhibits the growth of cancer cells by various mechanisms, such as the stimulation of cancer cell apoptosis, cell cycle arrest, inhibition of cell replication, tumor growth, improvement of drug resistance, prevention of cancer cell intrusiveness and metastasis. This review article focuses on the anti-cancer and anti-metastatic potential of luteolin targeting various transcription factors, markers and signaling pathways associated with the repression of epithelial to mesenchymal transition.

Atherosclerosis is an inflammatory disease of high lethality associated with endothelial dysfunction. Due to the pathophysiological complexity and our incomplete understanding of the mechanisms for the development and progression of atherosclerosis, effective means for the prevention and treatment of atherosclerosis still need further exploration. This study was designed to investigate the potential effects and underlying mechanisms of aloe-emodin derivative (AED) on atherosclerosis. High fat diet (HFD) treated ApoE−/- mice were used as an animal model of atherosclerosis. Intragastric administration of aloe-emodin (AE) or AED for 12 weeks markedly reduced the atherosclerotic plaque in aorta with decreased plaque area, lipid accumulation, macrophage infiltration, collagen content and metabolic abnormalities. By comparison, AED produced more potent anti-atherosclerosis effects than AE at the same dose. AED enhanced production of autophagy flux in cultured human aortic endothelial cells (HAECs). Moreover, AED increased the expression of activating molecule in Beclin1-regulated autophagy 1 (AMBRA1), a key protein involved in autophagosome formation. Furthermore, knockdown of AMBRA1 blocked the promotion effect of AED on autophagy in HAECs. Taken together, AED facilitates endothelial autophagy via AMBRA1 during the progression of atherosclerosis, suggesting the potential application of this compound for atherosclerosis treatment.

BACKGROUND: Red blood cell distribution width (RDW) is associated with increased morbidity and mortality in several cardiovascular diseases. However, the prognostic significance of RDW in patients with hypertrophic obstructive cardiomyopathy (HOCM) who underwent septal myectomy remains unclear as no studies have been conducted on this topic. This study aimed to assess the prognostic significance of RDW in these patients. METHODS: A total of 867 adults with HOCM who underwent septal myectomy at Fuwai Hospital from 2011 to 2017 were retrospectively studied. All patients were assessed comprehensively, including their medical history, echocardiograms, and blood test results. RESULTS: The median age of patients was 47.9 [interquartile range (IQR), 37.0–56.0] years and 61.5% of patients were men. During a median follow-up period of 32 (IQR, 17–53) months, 26 patients died and 23 had a cardiovascular death during follow-up. Compared to patients in the lowest RDW quartile, those in the highest quartile had a significantly lower 5-year survival free from all-cause and cardiovascular death (95.9% vs. 87.6%, P

Spectral bandwidth correction is an effective way to obtain the original spectrum. However, the correct selection of optimal parameters used to recover the distortion spectrum in bandwidth correction algorithms has always been an important problem. To overcome the shortcomings of traditional parameter selection methods and obtain the optimal parameter, we propose a new optimal parameter selection method based on deep learning (DL). First, the database and neural network were constructed, and then the optimal parameters of corresponding algorithms were obtained through the training of the neural network. In order to verify the superiority of the optimal parameter selection method based on DL, the Levenberg–Marquardt (L-M) and Richardson–Lucy (R-L) algorithms with corresponding optimal parameters were compared with the traditional L-M and R-L algorithms to recover the distortion white light-emitting diode, Raman spectrum, and compact fluorescent lamp spectrum. The type A uncertainty and root mean square error values of the different cases were calculated. The results proved that, compared with the traditional methods for obtaining the optimal parameters, the neural network was capable of obtaining parameters that can make the bandwidth correction algorithm more efficient at recovering the distorted spectrum.

With the continuous development of the modern construction industry, electrical installation occupies an extremely important position in the construction process of modern construction projects, and has a great impact on the normal operation of the project itself. In actual construction, relevant units and personnel need to strengthen the attention and application of lightning protection and grounding technology to avoid the hazards of lightning disasters to the internal electrical equipment and personnel safety of the building, thereby promoting the progress and development of the building itself and the industry. In this regard, the article first explains the concept of building electrical lightning protection grounding technology and analyzes the significance of lightning protection grounding technology applied to building electrical installations and related measures. Finally, specific quality management countermeasures to ensure the operation normality and stability of modern building internal electrical engineering is proposed. The proposed method is to ensure the overall safety of the building, thereby promoting the healthy development of my country’s construction industry and society.

Hypertrophic cardiomyopathy (HCM) is characterized by multiple pathological features including myocyte hypertrophy, myocyte disarray, and interstitial fibrosis.This study sought to correlate myocardial histopathology with clinical characteristics of patients with obstructive HCM and post-operative outcomes following septal myectomy.The authors reviewed the pathological findings of the myocardial specimens from 1,836 patients with obstructive HCM who underwent septal myectomy from 2000 to 2016. Myocyte hypertrophy, myocyte disarray, interstitial fibrosis, and endocardial thickening were graded and analyzed.The median age at operation was 54.2 years (43.5 to 64.3 years), and 1,067 (58.1%) were men. A weak negative correlation between myocyte disarray and age at surgery was identified (ρ = -0.22; p 0.001). Myocyte hypertrophy (p 0.001), myocyte disarray (p 0.001), and interstitial fibrosis (p 0.001) were positively associated with implantable cardioverter-defibrillator implantation. Interstitial fibrosis (p 0.001) and endocardial thickening (p 0.001) were associated with atrial fibrillation pre-operatively. In the Cox survival model, older age (p 0.001), lower degree of myocyte hypertrophy (severe vs. mild hazard ratio: 0.41; 95% confidence interval: 0.19 to 0.86; p = 0.040), and lower degree of endocardial thickening (moderate vs. mild hazard ratio: 0.75; 95% confidence interval: 0.58 to 0.97; p = 0.019) were independently associated with worse post-myectomy survival. Among 256 patients who had genotype analysis, patients with pathogenic or likely pathogenic variants (n = 62) had a greater degree of myocyte disarray (42% vs. 15% vs. 20%; p = 0.022). Notably, 13 patients with pathogenic or likely pathogenic genetic variants of HCM had no myocyte disarray.Histopathology was associated with clinical manifestations including the age of disease onset and arrhythmias. Myocyte hypertrophy and endocardial thickening were negatively associated with post-myectomy mortality.

By using full body radiograph, the aim of the current study was to elucidate the expected degree of lower extremity compensatory change after long thoracolumbar realignment surgery with adult spinal deformity patient who had normal or only mild osteoarthritis on lower extremities.Two novel parameters were used for assessment of regional compensation of the lower extremity. The Pearson correlation test was used to assess the correlation of postoperative changes of lower extremity compensation with the other spinopelvic parameters.Overall, 113 spinal deformity patients (mean age was 54.5 years) were recruited and the average number of fused vertebrae was 13.3 ± 3.5. Except pelvic tilt (PT), postoperative sacrum-femur angle (SF) changes showed only moderate correlation with all angular spinopelvic parameters (r = 0.323-0.374;For adult spinal deformity patients who had normal or only mild osteoarthritis on the lower extremities underwent long thoracolumbar realignment surgery, the surgeon could expect improvement of compensatory change of the knee with correction of spinopelvic parameters. However, the degree of hip compensation improvement was relatively difficult to predict than that of the knee, except PT.

BACKGROUND The potential survival benefit of neoadjuvant chemotherapy (NC) in patients with advanced gastric cancer has been widely recognized. With the development of minimally invasive surgery, which is represented by laparoscopy, the effect of NC on the safety of laparoscopic gastrectomy remains to be further explored. AIM To compare the short-term outcomes of laparoscopic total gastrectomy (LTG) after NC (NC-LTG) with LTG alone. METHODS A total of 92 patients who underwent NC-LTG and 381 patients who received LTG alone at the Chinese PLA General Hospital between September 2015 and September 2020 were retrospectively included in our study. We used propensity-score matching (PSM) to balance baseline bias. After 1:1 PSM, 73 patients were included in each group with no statistically significant difference in baseline characteristics. RESULTS The NC-LTG group exhibited a longer operation time (244.10 ± 48.13 min vs 225.74 ± 45.33 min, P = 0.019) and increased intraoperative blood loss [150 (100-300) mL vs 100 (100-200) mL, P = 0.011] compared to the LTG group. The 30-d postoperative morbidity of the NC-LTG group was 20.5% (15/73), and that of the LTG group was 13.7% (10/73). There were no significant differences in 30-d severe complication rates or anastomotic leakage rates. Subgroup analysis showed that the patients with pTNM (pathological tumor-node-metastasis classification) T0N0-II in the NC-LTG group underwent a longer operation than the LTG group, while no significant difference was found in any perioperative index for the pTNM III patients. A multivariate analysis showed that an operation time longer than 240 min was an independent risk factor (odds ratio = 3.021, 95% confidence interval: 1.160-7.868, P = 0.024), while NC was not an independent risk factor for postoperative complications in LTG. CONCLUSION Despite a longer operation time and more blood loss after NC-LTG, which indicate surgical difficulty, NC-LTG exhibits acceptable short-term outcomes compared to LTG, suggesting the safety and feasibility of NC-LTG.