1. The INHANCE consortium: toward a better understanding of the causes and mechanisms of head and neck cancer
- Author
-
Neonila Szeszenia-Dabrowska, Dana Mates, Danièle Luce, Lorenzo Simonato, José Eluf-Neto, Michael Pawlita, Elaine M. Smith, Kim De Ruyck, Gwenn Menvielle, Cristina Bosetti, Deborah M. Winn, David Zaridze, Gabriella Cadoni, Keitaro Matsuo, Diego Serraino, Isabelle Stücker, Richard B. Hayes, Mia Hashibe, Andrew F. Olshan, Robert I. Haddad, David I. Conway, Guo-Pei Yu, Tatiana V. Macfarlane, Simone Benhamou, Chu Chen, Brenda Diergaarde, Maura L. Gillison, Paul Brennan, Michael D. McClean, Kristina Kjærheim, Vladimir Bencko, Peter Rudnai, Guojun Li, Eleonora Fabianova, Pagona Lagiou, Thomas L. Vaughan, Witold Zatonski, Silvia Franceschi, Gypsyamber D'Souza, Rayjean J. Hung, Victor Wünsch-Filho, Antonio Agudo, Yuan Chin Amy Lee, Martin Lacko, Erich M. Sturgis, Xavier Castellsagué, Fabio Levi, Luigino Dal Maso, Jolanta Lissowska, Carlo La Vecchia, Franco Merletti, Steve Schwartz, Oxana Shangina, Ariana Znaor, Gregory T. Wolf, Jonathan N. Hofmann, Ivana Holcatova, Wolfgang Ahrens, Rolando Herrero, Alexander W. Daudt, Kirsten B. Moysich, Heribert Ramroth, Karl T. Kelsey, Maria Paula Curado, Zuo-Feng Zhang, Ana M. B. Menezes, Philip Lazarus, Laura S. Rozek, Tongzhang Zheng, Paolo Boffetta, Jose P. Zevallos, Peter Thomson, Claire M. Healy, Stefania Boccia, Wilbert H.M. Peters, Stimson P. Schantz, Marta Vilensky, Joshua E. Muscat, Hermann Brenner, Sergio Koifman, Geoffrey Liu, Manoj B. Mahimkar, Leticia Fernandez, Winn, D.M., Lee, Y.-C., Hashibe, M., Boffetta, P., Agudo, A., Ahrens, W., Bencko, V., Benhamou, S., Boccia, S., Bosetti, C., Brennan, P., Brenner, H., Cadoni, G., Castellsague, X., Chen, C., Conway, D., Curado, M.P., D'Souza, G., Maso, L.D., Daudt, A.W., Ruyck, K.D., Diergaarde, B., Eluf-Neto, J., Fabianova, E., Fernandez, L., Franceschi, S., Gillison, M., Haddad, R.I., Hayes, R., Healy, C., Herrero, R., Hofmann, J., Holcátová, I., Hung, R., Kelsey, K., Kjaerheim, K., Koifman, S., Vecchia, C.L., Lacko, M., Lagiou, P., Lazarus, P., Levi, F., Li, G., Lissowska, J., Liu, G., Luce, D., Macfarlane, T., Mahimkar, M., Mates, D., Matsuo, K., McClean, M., Menezes, A., Menvielle, G., Merletti, F., Moysich, K., Muscat, J., Olshan, A., Pawlita, M., Peters, W.H.M., Ramroth, H., Rozek, L., Rudnai, P., Schantz, S., Schwartz, S., Serraino, D., Shangina, O., Simonato, L., Smith, E., Stucker, I., Sturgis, E.M., Szeszenia-Dabrowska, Neonila and Thomson, P., Vaughan, T., Vilensky, M., Wolf, G., Wünsch-Filho, V., Yu, G., Zaridze, D., Zatonski, W., Zevallos, J.P., Zhang, Z.-F., Zheng, T.-Z., and Znaor, A.
- Subjects
Larynx ,Data Pooling ,Oncology ,medicine.medical_specialty ,Research groups ,Alcohol Drinking ,Scientific productivity ,Risk Factors ,Internal medicine ,Epidemiology ,Humans ,Medicine ,Cooperative Behavior ,Family history ,Settore MED/42 - IGIENE GENERALE E APPLICATA ,General Dentistry ,business.industry ,Smoking ,Head and neck cancer ,Confounding ,medicine.disease ,Diet ,Surgery ,medicine.anatomical_structure ,Socioeconomic Factors ,Otorhinolaryngology ,Head and Neck Neoplasms ,epidemiology ,head and neck cancer ,Settore MED/31 - OTORINOLARINGOIATRIA ,business - Abstract
The International Head and Neck Cancer Epidemiology (INHANCE) consortium is a collaboration of research groups leading large epidemiology studies to improve the understanding of the causes and mechanisms of head and neck cancer. The consortium includes investigators of 35 studies who have pooled their data on 25 500 patients with head and neck cancer (i.e., cancers of the oral cavity, oropharynx, hypopharynx, and larynx) and 37 100 controls. The INHANCE analyses have confirmed that tobacco use and alcohol intake are key risk factors of these diseases and have provided precise estimates of risk and dose response, the benefit of quitting, and the hazard of smoking even a few cigarettes per day. Other risk factors include short height, lean body mass, low education and income, and a family history of head and neck cancer. Risk factors are generally similar for oral cavity, pharynx, and larynx, although the magnitude of risk may vary. Some major strengths of pooling data across studies include more precise estimates of risk and the ability to control for potentially confounding factors and to examine factors that may interact with each other. The INHANCE consortium provides evidence of the scientific productivity and discoveries that can be obtained from data pooling projects. © 2015 John Wiley & Sons A/S.
- Published
- 2015
- Full Text
- View/download PDF