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1. Acute Citrulline-Malate Supplementation Increases Total Work in Short Lower-Body Isokinetic Tasks for Recreationally Active Females During Menstruation

Author: Jordan M. Glenn, Ho-Cheng Lu, Joshua L. Gills, Blake Spliker, David Szymanski, Braden Romer, and Michelle Gray
Subjects: Total work, business.industry, medicine.drug_class, media_common.quotation_subject, Physiology, Repeated measures design, Physical Therapy, Sports Therapy and Rehabilitation, General Medicine, Placebo, During menstruation, Estrogen, Follicular phase, Medicine, Orthopedics and Sports Medicine, Analysis of variance, business, Menstrual cycle, media_common
Abstract: Gills, JL, Spliker, B, Glenn, JM, Szymanski, D, Romer, B, Lu, H-C, and Gray, M. Acute citrulline-malate supplementation increases total work in short lower-body isokinetic tasks for recreationally active females during menstruation. J Strength Cond Res XX(X): 000-000, 2021-Citrulline-Malate (CM) exhibits acute ergogenic benefits through nitric oxide production (NO) and augmentation of vasodilatory properties. Nitric oxide is upregulated by estrogen and may influence CM's ergogenic efficacy in women. Therefore, the objective of this study was to evaluate the acute effects of CM supplementation on lower-body isokinetic performance in recreationally active women. Nineteen women (23.5 ± 3.1 years; 164.8 ± 7.0 cm; 61.9 ± 27.4 kg; 28.8 ± 8.1% body fat) completed 2 randomized, double-blind, crossover trials consuming CM (8 g CM + 12 g dextrose) or placebo (12 g dextrose). For testing trials, subjects were in the menstruating portion of the follicular phase of their menstrual cycle. Subjects performed a 5-repetition isokinetic leg extension protocol (5RP) followed by a 50-repetition isokinetic leg extension protocol (50RP), 60 minutes after supplement consumption. Repeated measures analysis of variance analysis showed that CM significantly increased total work completed, relative total work, and total work during maximum repetition compared with placebo (p < 0.05); but no significant performance differences existed between trials for peak torque production (p = 0.14) for the 5RP. No significant differences were identified between trials for peak torque production (p = 0.69) or total work (p = 0.33) completed during the 50RP. CM increased total work completed during the 5RP, but provided no ergogenic benefit during the 50RP in recreationally active menstruating women. Citrulline-Malate amplifies power-based resistance exercise performance in women during the follicular phase of the menstrual cycle, potentially because of depressed estrogen levels. Additional research is needed to identify timing efficacy of CM to increase sport performance during each phase of the menstrual cycle.
Published: 2023

2. A rare case of iliopsoas abscess caused by a retained shrapnel from a blast injury

Author: Jonathan Tiong, Katherine Grant, and Andrew Gray
Subjects: Male, medicine.medical_specialty, Fifth lumbar vertebra, medicine.diagnostic_test, business.industry, Retained foreign body, Computed tomography, General Medicine, Middle Aged, medicine.disease, Foreign Bodies, Blast injury, Surgery, Blast Injuries, Rare case, medicine, Humans, Psoas Abscess, Psoas abscesses, Iliopsoas, business, Abscess, Tomography, X-Ray Computed
Abstract: Iliopsoas abscesses (IPA) are uncommon, with an associated mortality rate of up to 20%. We describe the case of a 55-year-old man war veteran who presented with an unusual cause of IPA secondary to retained foreign body (FB). His initial trauma 30 years before was a result of a blast injury with shrapnel penetration suffered after inadvertently driving over a landmine as an ambulance driver in a conflict region. A CT scan was performed, revealing a 13 mmx8 mm radio-opaque FB within the right psoas at the level of the fifth lumbar vertebra with a surrounding collection. Subsequent open surgical exploration removed two gravel fragments. Given the knowledge of a traumatic blast injury with retained FB and repeated episodes of sepsis, surgical exploration is warranted. To our knowledge, this is the first case of recurrent IPA secondary to a retained FB from a historical trauma.
Published: 2023

3. Effects of Injury Pattern and Treatment on Case Length and Disposition for Hand Injuries Treated Under a Workers' Compensation Claim

Author: Aaron D. Gray and Colby P Young
Subjects: medicine.medical_specialty, business.industry, Compensation (psychology), Hand Injuries, Workers' compensation, Disposition, Return to work, Occupational Injuries, Functional capacity evaluation, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Return to Work, medicine, Humans, Workers' Compensation, Orthopedics and Sports Medicine, Surgery, 030212 general & internal medicine, business, 030217 neurology & neurosurgery, Retrospective Studies
Abstract: Background: In treating occupational hand injuries under workers’ compensation, the 2 most important goals are to maximize patient function, ideally to preinjury levels, and permit a timely return to work (RTW). The purpose of this study was to determine factors affecting total case length, that is, the total time from injury until primary closure of a patient’s claim, and disposition among patients with hand injuries treated under workers’ compensation. Methods: All cases treated under workers’ compensation by a single fellowship-trained hand surgeon within a single year were retrospectively reviewed. A case is defined as the entire management and treatment of a single patient related to a single occupational injury incident. Independent variables included age, sex, body mass index, comorbidity, occupation, injury pattern, and treatment modality. Dependent variables included treatment duration from injury to case closure and final case disposition (RTW, functional capacity evaluation [FCE], or loss to follow-up [LTFU]). Comparison between groups was accomplished with analysis of variance. Multivariate linear and logistic regression analysis was performed to predict case length and disposition. Results: In all, 447 cases involving a workers’ compensation claim were reviewed. Among these, 75 (16.8%) were LTFU, 24 (5.4%) required an FCE, and 346 (77.4%) an RTW. The RTW cases averaged 138.5 days, whereas those requiring FCE averaged 331.5 days. Compared with average case length, crush injuries (76.8 days. P < .001) and fractures (111.8 days, P = .0224) had significantly shorter time to closure. In a multivariate linear model, cases of soft tissue and nerve injury were associated with longer case lengths, remaining open for an additional 56.8 and 347.1 days, respectively ( P < .001). Each treatment modality studied, therapy, injections, and surgery, was associated with an increase in case length. Conclusions: Cases requiring FCE were open significantly longer than those resulting in RTW. In addition, injury pattern and treatment modality were associated with significant variations in total case length. These results imply that a specific subset of patients, namely those with soft tissue and nerve injuries, may experience delayed resolution among patients treated under a workers’ compensation claim.
Published: 2023

4. Opioid use after outpatient elective general surgery: quantifying the burden of persistent use

Author: Collin Clarke, Ken Leslie, Luke Hartford, Kelly Vogt, Chris Vinden, Julie Ann M. Van Koughnett, Andrew McClure, Laura J. Allen, Daryl K. Gray, and Patrick B. Murphy
Subjects: medicine.medical_specialty, Abdominal pain, business.industry, Postoperative pain, Opioid use, Chronic pain, Pain management, medicine.disease, Anesthesiology and Pain Medicine, Opioid, Emergency medicine, Medicine, Outpatient elective, medicine.symptom, Risk factor, business, medicine.drug
Abstract: Purpose: Surgery is a major risk factor for chronic opioid use among patients who had not recently been prescribed opioids. This study identifies the rate of, and risk factors for, persistent opioid use following laparoscopic cholecystectomy and open inguinal hernia repair in patients not recently prescribed opioids. Methods: This retrospective population-based cohort study included all patients who had not been prescribed opioids in the 6 months prior to undergoing open inguinal hernia repair or laparoscopic cholecystectomy from January 2013 to July 2016 in Ontario. Opioid prescription was identified from the provincial Narcotics Monitoring System and data were obtained from the Institute for Clinical Evaluative Sciences. The primary outcome was persistent opioid use after surgery (3, 6, 9 and 12 months). Associated risk factors and prescribing patterns were also examined. Results: Among the 90,326 patients in the study cohort, 80% filled an opioid prescription after surgery, with 11%, 9%, 5% and 1% filling a prescription at 3, 6, 9 and 12 months, respectively. Significant variability was identified in the type of opioid prescribed (41% codeine, 31% oxycodone, 18% tramadol) and in regional prescribing patterns (mean prescription/region range, 135–225 oral morphine equivalents). Predictors of continued opioid use included age, female gender, lower income quintile and being operated on by less experienced surgeons. Conclusion: Most patients who undergo elective cholecystectomy and hernia repair will fill a prescription for an opioid after surgery, and many will continue to fill opioid prescriptions for considerably longer than clinically anticipated. There is important variability in opioid type, regional prescribing patterns and risk factors that identify strategic targets to reduce the opioid burden in this patient population.
Published: 2023

5. Healthy Volunteers Immediately Adapt to Submental Stimulation During Swallowing

Author: Mohammed F. Safi, Lincoln Gray, Christy L. Ludlow, and Sandra B. Martin
Subjects: Male, Larynx, Laryngeal vestibule, Movement, Stimulation, stomatognathic system, Swallowing, Healthy volunteers, otorhinolaryngologic diseases, medicine, Humans, business.industry, Swallowing Disorders, digestive, oral, and skin physiology, Hyoid Bone, General Medicine, Dysphagia, Healthy Volunteers, Deglutition, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Neurology, Vestibule, Anesthesia, Neurology (clinical), medicine.symptom, Deglutition Disorders, business
Abstract: OBJECTIVES Transcutaneous stimulation above and below the hyoid is used to assist patients with swallowing disorders (dysphagia) but has shown different effects. Previously, infrahyoid transcutaneous stimulation lowered the hyoid and larynx resisting swallowing movement while suprahyoid stimulation had no effects on hyolaryngeal movement either at rest or during swallowing. More recently, large submental electrodes, covering the submental region, are used for swallowing therapy in combination with resistance therapy. To gain insight into the effects of these electrodes on movement during swallowing, we studied healthy volunteers using videofluoroscopy (VF). We hypothesized that submental electrical stimulation might elevate the hyoid but not the larynx increasing vestibular opening potentially reducing swallowing safety. MATERIALS AND METHODS While undergoing VF, seven healthy volunteers (mean age 51, 5 males) swallowed 5 mL of liquid barium on at least ten trials randomly ordered across three conditions: stimulation at rest, swallowing without stimulation, and swallowing with stimulation. RESULTS During stimulation at rest, significant (one tailed p
Published: 2022

6. Sensory processing and detection thresholds of burn-injured patients: A comparison to normative data

Author: E. Crofton, Jennifer Strong, Paul Gray, and Pamela Meredith
Subjects: Adult, Pain Threshold, medicine.medical_specialty, Adolescent, Sensory processing, medicine.medical_treatment, Pain, Sensory system, Audiology, Critical Care and Intensive Care Medicine, Secondary analysis, medicine, Humans, Outpatient clinic, Pain Measurement, Sensory sensitivity, business.industry, General Medicine, Compression garment, Cross-Sectional Studies, Sensory Thresholds, Cohort, Emergency Medicine, Normative, Surgery, Burns, business
Abstract: Objective There is emerging evidence that individual levels of sensory sensitivity may impact treatment outcomes for people recovering from burn injuries. For example, individuals with higher levels of sensory sensitivity were less adherent with compression garment wear, often used for scar management. The purpose of this study was to characterise sensory patterns for a sample of burn-injured patients as a cohort, using normative data as the reference. As different patterns of sensory processing can have implications clinically, understanding this at the cohort level may provide valuable insight for therapy. Method This was a secondary analysis of data collected during a cross-sectional study. Adults (N=117) attending the Professor Stuart Pegg Adult Burns Unit outpatient clinic completed the Adolescent/Adult Sensory Profile and the following quantitative sensory tests: two-point discrimination; mechanical detection threshold; and pressure pain threshold. Results Compared to matched normative data, burn-injured patients reported higher levels of sensory sensitive and avoiding patterns, and experienced lower detection thresholds for touch and pain. Conclusions Higher reports of sensory sensitivity and sensory avoiding, and lower thresholds for touch and pain, have been correlated with tactile defensiveness. Tactile defensiveness has been associated with social withdrawal and isolation, all of which could contribute to decreased engagement in therapy. The ways in which these sensory characteristics impact on burn-related treatments, such as compression garment adherence, warrant further investigation.
Published: 2022

7. Using artificial intelligence in a primary care setting to identify patients at risk for cancer: a risk prediction model based on routine laboratory tests

Author: Soeren Gray Worsoe Laursen, Jonna Skov Madsen, Ivan Brandslund, Henry Christensen, Christian Hardahl, and Patricia Diana Soerensen
Subjects: Framingham Risk Score, Primary Health Care, Receiver operating characteristic, business.industry, Biochemistry (medical), Clinical Biochemistry, Routine laboratory, Cancer, General Medicine, Primary care, Logistic regression, medicine.disease, Sensitivity and Specificity, ROC Curve, Artificial Intelligence, Neoplasms, Cohort, medicine, Humans, Artificial intelligence, Internal validation, business
Abstract: Objectives To evaluate the ability of an artificial intelligence (AI) model to predict the risk of cancer in patients referred from primary care based on routine blood tests. Results obtained with the AI model are compared to results based on logistic regression (LR). Methods An analytical profile consisting of 25 predefined routine laboratory blood tests was introduced to general practitioners (GPs) to be used for patients with non-specific symptoms, as an additional tool to identify individuals at increased risk of cancer. Consecutive analytical profiles ordered by GPs from November 29th 2011 until March 1st 2020 were included. AI and LR analysis were performed on data from 6,592 analytical profiles for their ability to detect cancer. Cohort I for model development included 5,224 analytical profiles ordered by GP’s from November 29th 2011 until the December 31st 2018, while 1,368 analytical profiles included from January 1st 2019 until March 1st 2020 constituted the “out of time” validation test Cohort II. The main outcome measure was a cancer diagnosis within 90 days. Results The AI model based on routine laboratory blood tests can provide an easy-to use risk score to predict cancer within 90 days. Results obtained with the AI model were comparable to results from the LR model. In the internal validation Cohort IB, the AI model provided slightly better results than the LR analysis both in terms of the area under the receiver operating characteristics curve (AUC) and PPV, sensitivity/specificity while in the “out of time” validation test Cohort II, the obtained results were comparable. Conclusions The AI risk score may be a valuable tool in the clinical decision-making. The score should be further validated to determine its applicability in other populations.
Published: 2022

8. Success in pediatric surgery: An updated survey of Program Directors 2020

Author: L. Grier Arthur, Brian W. Gray, Barbara A. Gaines, Jordan E. Jackson, Benedict C. Nwomeh, Grace Z. Mak, Richard G. Weiss, Cynthia D. Downard, Aaron P. Garrison, Mackenzie L. Shindorf, Nicole M. Chandler, Shreya Gupta, Paul D. Danielson, Peter F. Ehrlich, Michel Lallier, Patrick J. Javid, and Edward Tagge
Subjects: Canada, Matriculation, medicine.medical_specialty, media_common.quotation_subject, Specialties, Surgical, Likert scale, Phone, Surveys and Questionnaires, Pediatric surgery, medicine, Humans, Quality (business), Fellowships and Scholarships, Child, Curriculum, Retrospective Studies, media_common, Teamwork, Medical education, business.industry, Internship and Residency, General Medicine, Ranking, Pediatrics, Perinatology and Child Health, Surgery, business
Abstract: Background : One of the most competitive surgical sub-specialty fellowships remains Pediatric Surgery (PS), which requires candidates to develop a strong and research-oriented curriculum vitae. Although some objective factors of matriculation are known, factors for the interview selection and ranking per the program directors (PDs) have not been reviewed in over a decade. Methods : A web-based survey of US and Canadian PS program directors (PDs) (n=58) was used to evaluate a comprehensive list of factors in the selection criteria for PS fellowships. A mix of dichotomous, ranking, five-point Likert scale, and open-ended questions evaluated applicant characteristics, ABSITE scores, research productivity, interview day, and rank order criteria. Results : Fifty-five programs responded to the survey for a 95% participation rate. PDs desired an average of two years in dedicated research and weighted first authorship and total number of publications heavily. Only 38% of programs used an ABSITE score cutoff for offering interviews; however, the majority agreed that an overall upward trend was important. Quality letters of recommendation, especially from known colleagues, carried weight when deciding to offer interviews. Interview performance, being a team player, observed interpersonal interactions, perceived operative skills and patient care, and leadership were some of the notable factors when finalizing rank lists. Conclusions : A multitude of factors define a successful matriculant, including quality of letters of recommendation, quality and quantity of publications, supportive phone calls, observed interactions, interview performance, perceptions of being team player with leadership skills as well as perceptions of good operative skills and patient care.
Published: 2022

9. CONE PHOTORECEPTOR INTEGRITY ASSESSED WITH ADAPTIVE OPTICS IMAGING AFTER LASER POINTER-INDUCED RETINAL INJURY

Author: Frederick H. Davidorf, Carol Vitellas, Elaine Wells-Gray, Nayanika Challa, Stacey S. Choi, and Nathan Doble
Subjects: Optics and Photonics, medicine.medical_specialty, genetic structures, law.invention, chemistry.chemical_compound, Eye Injuries, Retinal Diseases, Optical coherence tomography, law, Foveal, Ophthalmology, Humans, Medicine, Adaptive optics, Retina, medicine.diagnostic_test, business.industry, Lasers, Fundus photography, Retinal, General Medicine, Laser, eye diseases, Ophthalmoscopy, medicine.anatomical_structure, chemistry, Retinal Cone Photoreceptor Cells, Laser pointer, sense organs, business, Tomography, Optical Coherence
Abstract: PURPOSE To examine the three-dimensional foveal cone photoreceptor structure in a patient who had suffered laser pointer induced retinal injury. METHODS Patient underwent standard fundus photography and clinical spectral domain optical coherence tomography (SD-OCT) imaging. High-resolution imaging was performed using an Adaptive Optics-OCT-Scanning Laser Ophthalmoscope (AO-OCT-SLO). RESULTS AO imaging revealed loss of inner and outer segments of cone photoreceptors while the anterior retinal layers appeared healthy. Analysis of cone topology showed an increase in Voronoi domain area and a less regular hexagonal packing structure closer to the lesion site. CONCLUSION Exposure to laser pointer radiation, however brief, can result in damage to the retina. Here, repeated imaging nine months later showed a decrease in the size of the lesions (ranging from 3.7 to 23.9%) compared to the first time point. However, the longer-term prognosis is likely permanent scarring.
Published: 2022

10. Correlating oxygen delivery on cardiopulmonary bypass with Society of Thoracic Surgeons outcomes following cardiac surgery

Author: J. Trent Magruder, Stuart J. Weiss, Katie Gray DeAngelis, John Haddle, Nimesh D. Desai, Wilson Y. Szeto, Michael A. Acker, Andrew Acker, Marijan Koprivanac, Joshua C. Grimm, Saumil J. Patel, Stephanie Ottemiller, and Marisa Cevasco
Subjects: Pulmonary and Respiratory Medicine, Mean arterial pressure, medicine.medical_specialty, 030204 cardiovascular system & hematology, law.invention, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, law, Cardiopulmonary bypass, medicine, Humans, cardiovascular diseases, Cardiac Surgical Procedures, Stroke, Retrospective Studies, Surgeons, Body surface area, Cardiopulmonary Bypass, business.industry, Acute kidney injury, medicine.disease, Surgery, Cardiac surgery, Oxygen, surgical procedures, operative, medicine.anatomical_structure, 030228 respiratory system, Cardiology and Cardiovascular Medicine, business, Perfusion, Artery
Abstract: Background The relationship between low oxygen delivery (DO2) on cardiopulmonary bypass and morbidity and mortality following cardiac surgery remains unexamined. Methods We reviewed patients undergoing Society of Thoracic Surgeons index procedures from March 2019 to July 2020, coincident with implementation of a new electronic perfusion record that provides for continuous recording of DO2 and flow parameters. Continuous perfusion variables were analyzed using area-over-the-curve (AOC) calculations below predefined thresholds (DO2 24 hours, stroke, sternal wound infection, and reoperation). Results Eight hundred thirty-four patients were included; 42.7% (356) underwent isolated coronary artery bypass grafting (CABG), whereas 57.3% underwent nonisolated CABG (eg, valvular or combined CABG/valvular operations). DO2 24 hours (P = .04), an effect again most pronounced in nonisolated-CABG cases (P = .002), as well as acute kidney injury Conclusions Low DO2 on bypass may be associated with morbidity/mortality following cardiac surgery, particularly in patients undergoing nonisolated CABG. These results underscore the importance of goal-directed perfusion strategies.
Published: 2022

11. Open abdomen during extracorporeal membrane oxygenation is a safe and effective treatment for abdominal compartment syndrome

Author: Joshua W. Brown, Brielle Warnock, Matthew L Friedman, Brian W. Gray, Michael J. Hobson, and Eamaan Turk
Subjects: Inotrope, medicine.medical_specialty, Abdominal compartment syndrome, medicine.medical_treatment, Extracorporeal Membrane Oxygenation, Abdomen, Extracorporeal membrane oxygenation, Humans, Medicine, Effective treatment, Respiratory system, Child, Open abdomen, Retrospective Studies, business.industry, Abdominal Cavity, General Medicine, medicine.disease, Surgery, body regions, Treatment Outcome, surgical procedures, operative, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Cohort, Intra-Abdominal Hypertension, business
Abstract: Background/Purpose Decompressive laparotomy and open abdomen for abdominal compartment syndrome have been historically avoided during Extracorporeal Membrane Oxygenation (ECMO) due to seemingly elevated risks of bleeding and infection. Our goal was to evaluate a cohort of pediatric respiratory ECMO patients who underwent decompressive laparotomy with open abdomen at a single institution and to compare these patients to ECMO patients without open abdomen. Methods We reviewed all pediatric respiratory ECMO (30 days-18 years) patients treated with decompressive laparotomy with open abdomen at Riley Hospital for Children (1/2000-12/2019) and compared these patients to concurrent respiratory ECMO patients with closed abdomen. We excluded patients with surgical cardiac disease. We assessed demographics, ECMO data, and outcomes and defined significance as p=0.05. Results 6 of 81 ECMO patients were treated with decompressive laparotomy and open abdomen. Open and closed abdomen groups had similar age (p=0.223) and weight (0.286) at cannulation, but the open abdomen group had a higher reliance on vasoactive medications (Vasoactive Inotropic Score, p=0.040). Open abdomen group survival was similar to closed abdomen patients (66.7%, vs 62.7%, p=1). Open abdomen patients had lower incidence of ECMO complications (33.3% vs 83.6%, p=0.014), but the groups had similar bleeding complications (p=0.412) and PRBC transfusion volume (p=0.941). Conclusion/Impact Pediatric ECMO patients with open abdomen after decompressive laparotomy had similar survival, blood products administered, and complications as those with a closed abdomen. An open abdomen is not a contra-indication to ECMO support in pediatric respiratory patients and should be considered in select patients.
Published: 2022

12. Comparison of <scp>Patient‐Reported</scp> Outcomes Measurement Information System Computerized Adaptive Testing Versus Fixed Short Forms in Juvenile Myositis

Author: Valeria G. Esparza, Rowland W. Chang, Bryce B. Reeve, Jin Shei Lai, Elizabeth Gray, David Cella, Ruchi N. Patel, and Kaveh Ardalan
Subjects: medicine.medical_specialty, business.industry, medicine.disease, Short Forms, Standard error, McNemar's test, Rheumatology, Physical therapy, medicine, Stopping rules, Juvenile, Anxiety, Computerized adaptive testing, medicine.symptom, business, Myositis
Abstract: OBJECTIVE Patient-Reported Outcomes Measurement Information System® (PROMIS® ) measures can be administered via computerized adaptive testing (CAT) or fixed short forms (FSF), but the empirical benefits of CAT versus FSF are unknown in juvenile myositis (JM). This study assesses if PROMIS CAT is feasible, precise, correlated with FSF, and less prone to respondent burden and floor/ceiling effects than FSF in JM. METHODS Patients 8-17 yo (self-report and parent proxy) and parents of patients 5-7 yo (only parent proxy) completed PROMIS Fatigue, Pain Interference, Upper Extremity Function, Mobility, Anxiety and Depressive Symptoms measures. Pearson correlations, paired t-tests, and Cohen's D were calculated between PROMIS CAT and FSF. McNemar test assessed floor/ceiling effects between CAT and FSF. Precision and respondent burden were examined across the T-score range. RESULTS Data from 67 patient-parent dyads were analyzed. CAT and FSF mean scores did not significantly differ except in parent proxy Anxiety and Fatigue (effect size: 0.23 and 0.19, respectively). CAT had less pronounced floor/ceiling effects at the less symptomatic extreme in all domains except self-report Anxiety. Increased item burden and higher standard errors were seen in less symptomatic scorers for CAT. Modified stopping rules limiting CAT item administration did not decrease precision. CONCLUSION PROMIS CAT appears to be feasible and correlated with FSF. CAT had less pronounced floor/ceiling effects, allowing detection of individual differences in less symptomatic patients. Modified stopping rules for CAT may decrease respondent burden. CAT can be considered for long-term follow-up of JM patients.
Published: 2022

13. Lifetime cost of HIV management in Australia: an economic model

Author: Jason J. Ong, Jisoo A. Kwon, Richard Gray, Jolie Hutchinson, Megumi Lim, and Angela Devine
Subjects: Actuarial science, Cost estimate, business.industry, Declaration, Public Health, Environmental and Occupational Health, Hiv management, Investment (macroeconomics), Confidence interval, Infectious Diseases, Health care, Economic model, business, Publication, health care economics and organizations
Abstract: Background: Antiretroviral therapy (ART) for HIV has significantly reduced morbidity and mortality, but the drugs can be expensive. This study aims to estimate the lifetime cost of HIV management from the Australian healthcare perspective. Methods: A Markov cohort model, consisting of 21 health states based on CD4 count and line of ART, simulated disease progression over the lifetime of persons living with HIV. We reported costs using 2019 Australian dollars (A$) at a discount rate of 3·5% per annum. One-way sensitivity analysis was used to assess the impact of model inputs, and probabilistic sensitivity analyses were conducted to calculate the 95% confidence intervals for the lifetime cost estimate. Findings: The average discounted lifetime cost of HIV management was A$282,093 [95% CI: $194,206 – 421,345]. The largest proportion of lifetime cost was due to ART (92%). The lifetime cost was most sensitive to third- and second-line ART costs, followed by the probability of failing third-line therapy for those with CD4 count
Published: 2022

14. A High-Frequency MMC for DC–DC Applications Using a Three-Winding Transformer With DC Flux Cancellation

Author: Ziyi Ma, Peter W. Lehn, and Philippe A. Gray
Subjects: Materials science, business.industry, Electrical engineering, Flux, General Medicine, business, Transformer (machine learning model)
Published: 2022

15. A Modular Multilevel DC–DC Converter With Flying Capacitor Converter Like Properties

Author: Peter W. Lehn, Netan Yakop, and Philippe A. Gray
Subjects: Forward converter, Computer science, business.industry, 020208 electrical & electronic engineering, String (computer science), Topology (electrical circuits), 02 engineering and technology, Modular design, Current source, 7. Clean energy, Reduction (complexity), Control and Systems Engineering, 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, Voltage source, Electrical and Electronic Engineering, business, Polarity (mutual inductance)
Abstract: In this paper, a novel modular multilevel dc-dc converter with high power-density potential is proposed based on a cascaded string of voltage source submodules (VSM) merged with a current source submodule (CSM) that is configured to rapidly invert the polarity of the current in the VSM string. The proposed hybrid converter combines the i) modularity advantages of the modular multilevel converter (MMC) and ii) the high effective frequency advantages of the flying capacitor converter (FCC). Unlike other hybrid non-isolated MMC structures the proposed converter features a novel CSM stage enabling i) a near 50% reduction in string current, and ii) the input source and output load to be commonly grounded. In addition, the proposed operational approach enables self-balancing of the VSMs and a simple overall control structure. This article introduces the main operating principles of this novel topology termed the Current Shaping Modular Multilevel Forward Converter (CS-M2FC) along with a proposed control design. A peak efficiency of 97.1% is measured for a laboratory-scale prototype at 950-137V and 1.45 kW.
Published: 2022

16. Reducing New Ileostomy Readmissions in a Rural Health Care Setting: A Quality Improvement Initiative

Author: Matthew Z. Wilson, Robert D. Shaw, Jessica Henkin, Brant Oliver, Srinivas J. Ivatury, Mark A. Eid, Jenaya L. Goldwag, and Philip P. Gray
Subjects: medicine.medical_specialty, Quality management, Ileostomy, business.industry, medicine.medical_treatment, Gastroenterology, Psychological intervention, Rural Health, General Medicine, Single Center, Patient Readmission, Quality Improvement, Colorectal surgery, Emergency medicine, Humans, Medicine, Oral rehydration therapy, business, PDCA, Retrospective Studies, Patient education
Abstract: Readmission after ileostomy creation continues to be a major cause of morbidity with rates ranging from 15% to 30% due to dehydration and obstruction. Rural environments pose an added risk of readmission due to larger travel distances and lack of consistent home health services.This study aimed to reduce ileostomy-related readmission rates in a rural academic medical center.This is a rapid cycle quality improvement study.This single-center study was conducted in a rural academic medical center.Colorectal surgery patients receiving a new ileostomy were included in this study.Improvement initiatives were identified through Plan-Do-Study-Act cycles (enhanced team continuity, standardized rehydration, nursing/staff education).Thirty-day readmission, average length of stay, and average time to readmission served as main outcome measures.Roughly equal rates of ileostomy were created in each time point, consistent with a tertiary care colorectal practice. The preimplementation readmission rate was 29%. Over the course of the entire quality improvement initiative, re-admission rates decreased by more than 50% (29% to 14%). PDSA cycle 1, which involved integrating a service-specific physician assistant to the team, allowed for greater continuity of care and had the most dramatic effect, decreasing rates by 27.5% (29% to 21%). Standardization of oral rehydration therapy and the implementation of a patient-directed intake/output sheet during PDSA cycle 2 resulted in further improvement in readmission rates (21% to 15%). Finally, implementation of nurse and physician assistant (PA)-driven patient education on fiber supplementation resulted in an additional yet nominal decrease in readmissions (15% to 14%). Latency to readmission also significantly increased throughout the study period.This study was limited by its small sample size in a single-center study.Implementation of initiatives targeting enhanced team continuity, the standardization of rehydration therapies, and improved patient education decreased readmission rates in patients with new ileostomies. Rural centers, where outpatient resources are not as readily available or accessible, stand to benefit the most from these types of targeted interventions to decrease readmission rates. See Video Abstract at http://links.lww.com/DCR/B771.ANTECEDENTES:La readmisión después de la creación de una ileostomía sigue siendo una de las principales causas de morbilidad con tasas que oscilan entre el 15% y el 30% debido a la deshidratación y la oclusión. Un entorno rurale presenta un riesgo adicional de readmisión debido a las mayores distancias de viaje y la falta de servicios de salud domiciliarios adecuados.OBJETIVO:Reducir las tasas de reingreso por ileostomía en un centro médico académico rural.DISEÑO:Estudio de mejoría de la calidad de ciclo rápido.AJUSTE:Estudio unicéntrico en una unidad de servicio médico académico rural.PACIENTES:Pacientes de cirugía colorrectal a quienes se les confeccionó una ileostomía.INTERVENCIONES:Iniciativas de mejoría identificadas a través de los ciclos Planificar-Hacer-Estudiar-Actuar (Continuidad del equipo mejorada, rehidratación estandarizada, educación de enfermería / personal).PRINCIPALES MEDIDAS DE RESULTADO:30 días de readmisión, duración media de la estadía hospitalaria, tiempo medio de reingreso.RESULTADOS:Se crearon tasas aproximadamente iguales de ileostomías un momento dado de tiempo, subsecuentes en la práctica colorrectal de atención terciaria. La tasa de readmisión previa a la implementación del estudio fue del 29%. En el transcurso de toda la iniciativa de mejoría en la calidad, las tasas de readmisión disminuyeron en más del 50% (29% a 14%). El ciclo 1 de PDSA, que implicó la integración en el equipo de un asistente médico específico, lo que permitió una mayor continuidad en la atención y tuvo el mayor efecto disminuyendo las tasas en un 27,5% (29% a 21%). La estandarización de una terapia de rehidratación oral y la implementación de una hoja de ingresos / perdidas dirigida al paciente durante el ciclo 2 de PDSA resultó en una mejoría adicional en las tasas de readmisión (21% a 15%). Finalmente, la implementación de la educación del paciente impulsada por enfermeras y AF sobre el consumo suplementario de dietas con fibra dio como resultado una disminución adicional, aunque nominal, de las readmisiones (15% a 14%). La latencia hasta la readmisión también aumentó significativamente durante el período de estudio.LIMITACIONES:Estudio de un solo centro con un muestreo de pequeño tamaño.CONCLUSIONES:La implementación de iniciativas dirigidas a mejorar la continuidad en el equipo, la estandarización de las terapias de rehidratación y la mejoría en la información de los pacientes disminuyeron las tasas de readmisión en todos aquellas personas con nuevas ileostomías. Los centros rurales, donde los recursos para pacientes ambulatorios no están tan fácilmente disponibles o accesibles, son los que más beneficiaron de este tipo de intervenciones específicas para reducir las tasas de readmisión. Consulte Video Resumen en http://links.lww.com/DCR/B771. (Traducción-Dr. Xavier Delgadillo).
Published: 2022

17. Inter-Phase 4D Cardiac MRI Registration With a Motion Prior Derived From CTA

Author: Mingsong Cao, Ran Yan, Dan Ruan, Michael F. McNitt-Gray, Yingli Yang, Peng Hu, Yudi Sang, and Yu Gao
Subjects: Landmark, Computed Tomography Angiography, Computer science, Image quality, business.industry, Biomedical Engineering, Magnetic Resonance Imaging, Regularization (mathematics), Motion, symbols.namesake, Hausdorff distance, Software, Robustness (computer science), Jacobian matrix and determinant, Image Processing, Computer-Assisted, symbols, Computer vision, Artificial intelligence, Tomography, X-Ray Computed, Representation (mathematics), business, Algorithms
Abstract: Registration between phases in 4D cardiac MRI is essential for reconstructing high-quality images and appreciating the dynamics. Complex motion and limited image quality make it challenging to design regularization functionals. We propose to introduce a motion representation model (MRM) into a registration network to impose customized, site-specific, and spatially variant prior for cardiac motion.We propose a novel approach to regularize deep registration with a deformation vextor field (DVF) representation model using computed tomography angiography (CTA). In the form of a convolutional auto-encoder, the MRM was trained to capture the spatially variant pattern of feasible DVF Jacobian. The CTA-derived MRM was then incorporated into an unsupervised network to facilitate MRI registration. In the experiment, 10 CTAs were used to derive the MRM. The method was tested on 10 0.35 T scans in long-axis view with manual segmentation and 15 3 T scans in short-axis view with tagging-based landmarks.Introducing the MRM improved registration accuracy and achieved 2.23, 7.21, and 4.42 mm 80% Hausdorff distance on left ventricle, right ventricle, and pulmonary artery, respectively, and 2.23 mm landmark registration error. The results were comparable to carefully tuned SimpleElastix, but reduced the registration time from 40 s to 0.02 s. The MRM presented good robustness to different DVF sample generation methods.The model enjoys high accuracy as meticulously tuned optimization model and the efficiency of deep networks.The method enables model to go beyond the quality limitation of MRI. The robustness to training DVF generation scheme makes the method attractive to adapting to the available data and software resources in various clinics.
Published: 2022

18. Treatment of GM2 Gangliosidosis in Adult Sandhoff Mice Using an Intravenous Self-Complementary Hexosaminidase Vector

Author: Cliff Heindel, Karlaina J.L. Osmon, Evan Woodley, John G. Keimel, Patrick Thompson, Subha Karumuthil-Melethil, William F. Kaemmerer, Jagdeep S. Walia, and Steven J. Gray
Subjects: Biodistribution, Gangliosidosis, Pharmacology, medicine.disease_cause, Mice, Gangliosidoses, GM2, In vivo, Drug Discovery, Genetics, Lysosomal storage disease, medicine, Animals, Humans, Tissue Distribution, Hexosaminidase, Molecular Biology, Adeno-associated virus, Genetics (clinical), business.industry, Sandhoff Disease, medicine.disease, HEXA, beta-N-Acetylhexosaminidases, Hexosaminidases, Toxicity, Molecular Medicine, business
Abstract: Background: GM2 gangliosidosis is a neurodegenerative, lysosomal storage disease caused by the deficiency of β-hexosaminidase A enzyme (Hex A), an α/β-subunit heterodimer. A novel variant of the human hexosaminidase α-subunit, coded by HEX M, has previously been shown to form a stable homodimer, Hex M, that hydrolyzes GM2 gangliosides (GM2) in vivo. Materials & Methods: The current study assessed the efficacy of intravenous (IV) delivery of a self-complementary adeno-associated virus serotype 9 (scAAV9) vector incorporating the HEXM transgene, scAAV9/HEXM, including the outcomes based on the dosages provided to the Sandhoff (SD) mice. Six-week-old SD mice were injected with either 2.5E+12 vector genomes (low dose, LD) or 1.0E+13 vg (high dose, HD). We hypothesized that when examining the dosage comparison for scAAV9/HEXM in adult SD mice, the HD group would have more beneficial outcomes than the LD cohort. Assessments included survival, behavioral outcomes, vector biodistribution, and enzyme activity within the central nervous system. Results: Toxicity was observed in the HD cohort, with 8 of 14 mice dying within one month of the injection. As compared to untreated SD mice, which have typical survival of 16 weeks, the LD cohort and the remaining HD mice had a significant survival benefit with an average/median survival of 40.6/34.5 and 55.9/56.7 weeks, respectively. Significant behavioral, biochemical and molecular benefits were also observed. The second aim of the study was to investigate the effects of IV mannitol infusions on the biodistribution of the LD scAAV9/HEXM vector and the survival of the SD mice. Increases in both the biodistribution of the vector as well as the survival benefit (average/median of 41.6/49.3 weeks) were observed. Conclusion: These results demonstrate the potential benefit and critical limitations of the treatment of GM2 gangliosidosis using IV delivered AAV vectors.
Published: 2022

19. Differentiation of Chiari malformation type 1 and spontaneous intracranial hypotension using objective measurements of midbrain sagging

Author: Timothy J. Amrhein, Michael D. Malinzak, Jessica L Houk, Peter G. Kranz, and Linda Gray
Subjects: education.field_of_study, business.industry, Unnecessary Surgery, Population, General Medicine, medicine.disease, Hydrocephalus, Midbrain, medicine.anatomical_structure, Clivus, medicine, Spontaneous Intracranial Hypotension, medicine.symptom, Nuclear medicine, business, education, Chiari malformation, Confusion
Abstract: OBJECTIVE Chiari malformation type 1 (CM-1) and spontaneous intracranial hypotension (SIH) are causes of headache in which cerebellar tonsillar ectopia (TE) may be present. An accurate method for differentiating these conditions on imaging is needed to avoid diagnostic confusion. Here, the authors sought to determine whether objective measurements of midbrain morphology could distinguish CM-1 from SIH on brain MRI. METHODS This is a retrospective case-control series comparing neuroimaging in consecutive adult subjects with CM-1 and SIH. Measurements obtained from brain MRI included previously reported measures of brain sagging: TE, slope of the third ventricular floor (3VF), pontomesencephalic angle (PMA), mamillopontine distance, lateral ventricular angle, internal cerebral vein–vein of Galen angle, and displacement of iter (DOI). Clivus length (CL), an indicator of posterior fossa size, was also measured. Measurements for the CM-1 group were compared to those for the entire SIH population (SIHall) as well as a subgroup of SIH patients with > 5 mm of TE (SIHTE subgroup). RESULTS Highly significant differences were observed between SIHall and CM-1 groups in the following measures: TE (mean ± standard deviation, 3.1 ± 5.7 vs 9.3 ± 3.5 mm), 3VF (−16.8° ± 11.2° vs −2.1° ± 4.6°), PMA (44.8° ± 13.1° vs 62.7° ± 9.8°), DOI (0.2 ± 4.1 vs 3.8 ± 1.6 mm), and CL (38.3 ± 4.5 vs 44.0 ± 3.3 mm; all p < 0.0001). Eight (16%) of 50 SIH subjects had TE > 5 mm; in this subgroup (SIHTE), a cutoff value of < −15° for 3VF and < 45° for PMA perfectly discriminated SIH from CM-1 (sensitivity and specificity = 1.0). DOI showed perfect specificity (1.0) in detecting SIH among both groups. No subjects with SIH had isolated TE without other concurrent findings of midbrain sagging. CONCLUSIONS Measures of midbrain sagging, including cutoff values for 3VF and PMA, discriminate CM-1 from SIH and may help to prevent misdiagnosis and unnecessary surgery.
Published: 2022

20. Conservatism Gets Funded? A Field Experiment on the Role of Negative Information in Novel Project Evaluation

Author: Karim R. Lakhani, Eva C. Guinan, Michael Menietti, Misha Teplitskiy, Hardeep Ranu, Gary S. Gray, and Jacqueline N. Lane
Subjects: Program evaluation, Knowledge management, business.industry, Computer science, Strategy and Management, Information sharing, Negative information, Negativity bias, Management Science and Operations Research, Conservatism, business, Selection (genetic algorithm)
Abstract: The evaluation and selection of novel projects lies at the heart of scientific and technological innovation, and yet there are persistent concerns about bias, such as conservatism. This paper investigates the role that the format of evaluation, specifically information sharing among expert evaluators, plays in generating conservative decisions. We executed two field experiments in two separate grant-funding opportunities at a leading research university, mobilizing 369 evaluators from seven universities to evaluate 97 projects, resulting in 761 proposal-evaluation pairs and more than $250,000 in awards. We exogenously varied the relative valence (positive and negative) of others’ scores and measured how exposures to higher and lower scores affect the focal evaluator’s propensity to change their initial score. We found causal evidence of a negativity bias, where evaluators lower their scores by more points after seeing scores more critical than their own rather than raise them after seeing more favorable scores. Qualitative coding of the evaluators’ justifications for score changes reveals that exposures to lower scores were associated with greater attention to uncovering weaknesses, whereas exposures to neutral or higher scores were associated with increased emphasis on nonevaluation criteria, such as confidence in one’s judgment. The greater power of negative information suggests that information sharing among expert evaluators can lead to more conservative allocation decisions that favor protecting against failure rather than maximizing success. This paper was accepted by Alfonso Gambardella, business strategy.
Published: 2022

21. Robotic Approach Has Improved Outcomes for Minimally Invasive Resection of Mediastinal Tumors

Author: Stephanie G. Worrell, Katelynn C. Bachman, Matthew Janko, Philip A. Linden, Christopher W. Towe, Christine E. Alvarado, Kelsey E. Gray, Boxiang Jiang, and Luis M. Argote-Greene
Subjects: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Adverse outcomes, Mediastinal tumor, Mediastinal Neoplasms, Resection, Robotic Surgical Procedures, Thoracoscopy, medicine, Overall survival, Humans, Minimally Invasive Surgical Procedures, Retrospective Studies, Surgical approach, medicine.diagnostic_test, Thoracic Surgery, Video-Assisted, business.industry, Margins of Excision, Cancer, Robotics, Perioperative, medicine.disease, Surgery, Treatment Outcome, Cardiology and Cardiovascular Medicine, business
Abstract: The optimal minimally invasive surgical approach to mediastinal tumors is unknown. There are limited reports comparing the outcomes of resection with robotic-assisted thoracoscopic surgery (RATS) and video-assisted thoracoscopic surgery (VATS) surgery. We hypothesized that patients who underwent RATS would have improved outcomes.The National Cancer Database was queried for all patients who underwent a minimally invasive surgical approach for any mediastinal tumor from 2010 to 2016. Patients were determined to have an adverse composite outcome if they had any of the adverse perioperative outcomes: conversion to open procedure, 90-day mortality, 30-day readmission, and positive pathologic margins. Secondary outcomes of interest were length of stay and overall survival. Multivariable logistic regression was used to assess likelihood of having a composite adverse outcome based on surgical approach.The study included 856 patients: 402 (47%) underwent VATS and 454 (53%) underwent RATS. RATS resections were associated with fewer conversions (4.9% vs 14.7%, P.001), fewer positive margins (24.3% vs 31.6%, P = .02), shorter length of stay (3.8 days vs 4.3 days, P = .01), and fewer composite adverse events (36.7% vs 51.3%, P.001). Multivariate analysis showed RATS (odds ratio, 0.44; P.001) was independently associated with a decreased likelihood of a composite adverse outcome, even among tumors exceeding 4 cm (odds ratio, 0.45; P = .001). Overall survival was similar between the 2 groups.Among patients who underwent a minimally invasive surgical approach for a mediastinal tumor, RATS had fewer adverse outcomes than VATS, even for tumors 4 cm or larger. These data suggests that RATS may be the preferred technique for patients who are candidates for minimally invasive resection of mediastinal tumors.
Published: 2022

22. Discontinuous Conduction Mode Operation of the Current-Shaping Modular Multilevel DC–DC Converter

Author: Philippe A. Gray and Peter W. Lehn
Subjects: Computer science, business.industry, Ripple, Energy Engineering and Power Technology, Converters, Modular design, Current source, Inductor, Capacitance, Electronic engineering, Voltage source, Electrical and Electronic Engineering, business, Voltage
Abstract: The Current Shaping Modular Multilevel DC-DC Converter (CS-MMC) is a recently proposed class of modular multilevel dc-dc converters for dc distribution grid applications consisting of a single string of cascaded voltage source submodule cells (VSMs), a current source submodule (CSM) and notably no series inductor. In the CS-MMC, since it is the CSM that shapes the string current and there is no series inductor, this frequency can readily be in the medium-frequency range, enabling VSM cells to be realized with low cell capacitance. In the previous work, only continuous conduction mode (CCM) operation of the CS-MMC had been considered which led to several limitations including elevated switching losses and low utilization of the semiconductor devices in low output voltage applications. In this work, discontinuous conduction mode (DCM) operation is proposed for the CS-MMC which addresses these limitations. In traditional dc-dc converters, DCM is determined by the inductor current ripple. However, unique to the CS-MMC, DCM is determined by the VSM capacitor voltage ripple. In this work, the proposed DCM operational approach is presented along with its analysis and control. Both simulation and experimental results from a laboratory scale converter system are provided for validation.
Published: 2022

23. Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Author: Alison Halliday, Richard Bulbulia, Leo H Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan, John Potter, Hans Henning Eckstein, Barbara Farrell, Marcus Flather, Averil Mansfield, Boby Mihaylova, Kazim Rahimi, David Simpson, Dafydd Thomas, Peter Sandercock, Richard Gray, Andrew Molyneux, Cliff P Shearman, Peter Rothwell, Anna Belli, Will Herrington, Parminder Judge, Peter Leopold, Marion Mafham, Michael Gough, Piergiorgio Cao, Sumaira MacDonald, Vasha Bari, Clive Berry, S Bradshaw, Wojciech Brudlo, Alison Clarke, Robin Cox, Susan Fathers, Kamran Gaba, Mo Gray, Elizabeth Hayter, Constance Holliday, Rijo Kurien, Michael Lay, Steffi le Conte, Jessica McManus, Zahra Madgwick, Dylan Morris, Andrew Munday, Sandra Pickworth, Wiktor Ostasz, Michiel Poorthuis, Sue Richards, Louisa Teixeira, Sergey Tochlin, Lynda Tully, Carol Wallis, Monique Willet, Alan Young, Renato Casana, Chiara Malloggi, Andrea Odero Jr, Vincenzo Silani, Gianfranco Parati, Giuseppe Malchiodi, Giovanni Malferrari, Francesco Strozzi, Nicola Tusini, Enrico Vecchiati, Gioacchino Coppi, Antonio Lauricella, Roberto Moratto, Roberto Silingardi, Jessica Veronesi, Andrea Zini, Emanuele Ferrero, Michelangelo Ferri, Andrea Gaggiano, Carmelo Labate, Franco Nessi, Daniele Psacharopulo, Andrea Viazzo, Giovanni Malacrida, Daniela Mazzaccaro, Giovanni Meola, Alfredo Modafferi, Giovanni Nano, Maria Teresa Occhiuto, Paolo Righini, Silvia Stegher, Stefano Chiarandini, Filippo Griselli, Sandro Lepidi, Fabio Pozzi Mucelli, Marcello Naccarato, Mario D'Oria, Barbara Ziani, Andrea Stella, Mortalla Dieng, Gianluca Faggioli, Mauro Gargiulo, Sergio Palermo, Rodolfo Pini, Giovanni Maria Puddu, Andrea Vacirca, Domenico Angiletta, Claudio Desantis, Davide Marinazzo, Giovanni Mastrangelo, Guido Regina, Raffaele Pulli, Paolo Bianchi, Lea Cireni, Elisabetta Coppi, Rocco Pizzirusso, Filippo Scalise, Giovanni Sorropago, Valerio Tolva, Valeria Caso, Enrico Cieri, Paola DeRango, Luca Farchioni, Giacomo Isernia, Massimo Lenti, Gian Battista Parlani, Guglielmo Pupo, Grazia Pula, Gioele Simonte, Fabio Verzini, Federico Carimati, Maria Luisa Delodovici, Federico Fontana, Gabriele Piffaretti, Matteo Tozzi, Efrem Civilini, Giorgio Poletto, Bernhard Reimers, Barbara Praquin, Sonia Ronchey, Laura Capoccia, Wassim Mansour, Enrico Sbarigia, Francesco Speziale, Pasqualino Sirignano, Danilo Toni, Roberto Galeotti, Vincenzo Gasbarro, Francesco Mascoli, Tiberio Rocca, Elpiniki Tsolaki, Giulia Bernardini, Ester DeMarco, Alessia Giaquinta, Francesco Patti, Massimiliano Veroux, Pierfrancesco Veroux, Carla Virgilio, Nicola Mangialardi, Matteo Orrico, Vincenzo Di Lazzaro, Nunzio Montelione, Francesco Spinelli, Francesco Stilo, Carlo Cernetti, Sandro Irsara, Giuseppe Maccarrone, Diego Tonello, Adriana Visonà, Beniamino Zalunardo, Emiliano Chisci, Stefano Michelagnoli, Nicola Troisi, Maela Masato, Massimo Dei Negri, Andrea Pacchioni, Salvatore Saccà, Giovanni Amatucci, Alfredo Cannizzaro, Federico Accrocca, Cesare Ambrogi, Renzo Barbazza, Giustino Marcucci, Andrea Siani, Guido Bajardi, Giovanni Savettieri, Angelo Argentieri, Riccardo Corbetta, Attilio Odero, Pietro Quaretti, Federico Z Thyrion, Alessandro Cappelli, Domenico Benevento, Gianmarco De Donato, Maria Agnese Mele, Giancarlo Palasciano, Daniela Pieragalli, Alessandro Rossi, Carlo Setacci, Francesco Setacci, Domenico Palombo, Maria Cecilia Perfumo, Edoardo Martelli, Aldo Paolucci, Santi Trimarchi, Viviana Grassi, Luigi Grimaldi, Giuliana La Rosa, Domenico Mirabella, Matteo Scialabba, Leonildo Sichel, Costantino L D'Angelo, Gian Franco Fadda, Holta Kasemi, Mario Marino, Francesco Burzotta, Francesco Alberto Codispoti, Angela Ferrante, Giovanni Tinelli, Yamume Tshomba, Claudio Vincenzoni, Deborah Amis, Dawn Anderson, Martin Catterson, Mike Clarke, Michelle Davis, Anand Dixit, Alexander Dyker, Gary Ford, Ralph Jackson, Sreevalsan Kappadath, David Lambert, Tim Lees, Stephen Louw, James McCaslin, Noala Parr, Rebecca Robson, Gerard Stansby, Lucy Wales, Vera Wealleans, Lesley Wilson, Michael Wyatt, Hardeep Baht, Ibrahim Balogun, Ilse Burger, Tracy Cosier, Linda Cowie, Gunaratnam Gunathilagan, David Hargroves, Robert Insall, Sally Jones, Hannah Rudenko, Natasha Schumacher, Jawaharlal Senaratne, George Thomas, Audrey Thomson, Tom Webb, Ellen Brown, Bernard Esisi, Ali Mehrzad, Shane MacSweeney, Norman McConachie, Alison Southam, Wayne Sunman, Ahmed Abdul-Hamiq, Jenny Bryce, Ian Chetter, Duncan Ettles, Raghuram Lakshminarayan, Kim Mitchelson, Christopher Rhymes, Graham Robinson, Paul Scott, Alison Vickers, Ray Ashleigh, Stephen Butterfield, Ed Gamble, Jonathan Ghosh, Charles N McCollum, Mark Welch, Sarah Welsh, Leszek Wolowczyk, Mary Donnelly, Stephen D'Souza, Anselm A Egun, Bindu Gregary, Thomas Joseph, Christine Kelly, Shuja Punekar, M Asad Rahi, Sonia Raj, Dare Seriki, George Thomson, James Brown, Ragunath Durairajan, Iris Grunwald, Paul Guyler, Paula Harman, Matthew Jakeways, Christopher Khuoge, Ashish Kundu, Thayalini Loganathan, Nisha Menon, Raji O Prabakaran, Devesh Sinha, Vicky Thompson, Sharon Tysoe, Dennis Briley, Chris Darby, Linda Hands, Dominic Howard, Wilhelm Kuker, Ursula Schulz, Rachel Teal, David Barer, Andrew Brown, Susan Crawford, Paul Dunlop, Ramesh Krishnamurthy, Nikhil Majmudar, Duncan Mitchell, Min P Myint, Richard O'Brien, Janice O'Connell, Naweed Sattar, Shanmugam Vetrivel, Jonathan Beard, Trevor Cleveland, Peter Gaines, John Humphreys, Alison Jenkins, Craig King, Daniel Kusuma, Ralph Lindert, Robbie Lonsdale, Raj Nair, Shah Nawaz, Faith Okhuoya, Douglas Turner, Graham Venables, Paul Dorman, Andrea Hughes, Deborah Jones, David Mendelow, Helen Rodgers, Aidas Raudoniitis, Peter Enevoldson, Hans Nahser, Imelda O'Brien, Francesco Torella, Dave Watling, Richard White, Pauline Brown, Dipankar Dutta, Lorraine Emerson, Paula Hilltout, Sachin Kulkarni, Jackie Morrison, Keith Poskitt, Fiona Slim, Sarah Smith, Amanda Tyler, Joanne Waldron, Mark Whyman, Milda Bajoriene, Lucy Baker, Amanda Colston, Bekky Eliot-Jones, Gita Gramizadeh, Catherine Lewis-Clarke, Laura McCafferty, Deborah Oliver, Debbie Palmer, Abhijeet Patil, Suzannah Pegler, Gopi Ramadurai, Aisling Roberts, Tracey Sargent, Shivaprasad Siddegowda, Ravi Singh-Ranger, Akintunde Williams, Lucy Williams, Steve Windebank, Tadas Zuromskis, Lanka Alwis, Jane Angus, Asaipillai Asokanathan, Caroline Fornolles, Diana Hardy, Sophy Hunte, Frances Justin, Duke Phiri, Marie Mitabouana-Kibou, Lakshmanan Sekaran, Sakthivel Sethuraman, Margaret L Tate, Joyce Akyea-Mensah, Stephen Ball, Angela Chrisopoulou, Elizabeth Keene, Alison Phair, Steven Rogers, John V Smyth, Colin Bicknell, Jeremy Chataway, Nicholas Cheshire, Andrew Clifton, Caroline Eley, Richard Gibbs, Mohammad Hamady, Beth Hazel, Alex James, Michael Jenkins, Nyma Khanom, Austin Lacey, Maz Mireskandari, Joanna O'Reilly, Antony Pereira, Tina Sachs, John Wolfe, Philip Davey, Gill Rogers, Gemma Smith, Gareth Tervit, Ian Nichol, Andrew Parry, Gavin Young, Simon Ashley, James Barwell, Francis Dix, Azlisham M Nor, Chris Parry, Angela Birt, Paul Davies, Jim George, Anne Graham, Leon Jonker, Nicci Kelsall, Caroline Potts, Toni Wilson, Jamie Crinnion, Larissa Cuenoud, Nikola Aleksic, Srdan Babic, Nenad Ilijevski, Đorde Radak, Dragan Sagic, Slobodan Tanaskovic, Momcilo Colic, Vladimir Cvetic, Lazar Davidovic, Dejana R Jovanovic, Igor Koncar, Perica Mutavdžic, Miloš Sladojevic, Ivan Tomic, Eike S Debus, Ulrich Grzyska, Dagmar Otto, Götz Thomalla, Jessica Barlinn, Johannes Gerber, Kathrin Haase, Christian Hartmann, Stefan Ludwig, Volker Pütz, Christian Reeps, Christine Schmidt, Norbert Weiss, Sebastian Werth, Simon Winzer, Janine Gemper, Albrecht Günther, Bianka Heiling, Elisabeth Jochmann, Panagiota Karvouniari, Carsten Klingner, Thomas Mayer, Julia Schubert, Friederike Schulze-Hartung, Jürgen Zanow, Yvonne Bausback, Franka Borger, Spiridon Botsios, Daniela Branzan, Sven Bräunlich, Henryk Hölzer, Janin Lenzer, Christopher Piorkowski, Nadine Richter, Johannes Schuster, Dierk Scheinert, Andrej Schmidt, Holger Staab, Matthias Ulrich, Martin Werner, Hermann Berger, Gábor Biró, Hans-Henning Eckstein, Michael Kallmayer, Kornelia Kreiser, Alexander Zimmermann, Bärbel Berekoven, Klaus Frerker, Vera Gordon, Giovanni Torsello, Sebastian Arnold, Cora Dienel, Martin Storck, Bernhard Biermaier, Hans Martin Gissler, Christof Klötzsch, Tomas Pfeiffer, Ralph Schneider, Leander Söhl, Michael Wennrich, Angelika Alonso, Michael Keese, Christoph Groden, Andreas Cöster, Andreas Engelhardt, Christoph-Maria Ratusinski, Bengt Berg, Martin Delle, Johan Formgren, Peter Gillgren, Lotta Jarl, Torbjörn B Kall, Peter Konrad, Niklas Nyman, Claes Skiöldebrand, Johnny Steuer, Rabbe Takolander, Jonas Malmstedt, Stefan Acosta, Katarina Björses, Kerstin Brandt, Nuno Dias, Anders Gottsäter, Jan Holst, Thorarinn Kristmundsson, Tobias Kühme, Tilo Kölbel, Bengt Lindblad, Mats Lindh, Martin Malina, Tomas Ohrlander, Tim Resch, Viola Rönnle, Björn Sonesson, Margareta Warvsten, Zbigniew Zdanowski, Erik Campbell, Per Kjellin, Hans Lindgren, Johan Nyberg, Björn Petersen, Gunnar Plate, Håkan Pärsson, Peter Qvarfordt, Pavel Ignatenko, Andrey Karpenko, Vladimir Starodubtsev, Mikhail A Chernyavsky, Maria S Golovkova, Boris B Komakha, Nikolay N Zherdev, Andrey Belyasnik, Pavel Chechulov, Dmitry Kandyba, Igor Stepanishchev, Csaba Csobay-Novák, Edit Dósa, László Entz, Balázs Nemes, Zoltán Szeberin, Pál Barzó, Mihaly Bodosi, Eniko Fákó, Béla Fülöp, Tamás Németh, Szilárd Pazdernyik, Krisztina Skoba, Erika Vörös, Eleni Chatzinikou, Athanasios Giannoukas, Christos Karathanos, Stylianos Koutsias, Georgios Kouvelos, Miltiadis Matsagkas, Styliani Ralli, Christos Rountas, Nikolaos Rousas, Konstantinos Spanos, Elias Brountzos, John D Kakisis, Andreas Lazaris, Konstantinos G Moulakakis, Leonidas Stefanis, Georgios Tsivgoulis, Spyros Vasdekis, Constantine N Antonopoulos, Ion Bellenis, Dimitrios Maras, Antonios Polydorou, Victoria Polydorou, Antonios Tavernarakis, Nikolaos Ioannou, Maria Terzoudi, Miltos Lazarides, Michalis Mantatzis, Kostas Vadikolias, Lukasz Dzieciuchowicz, Marcin Gabriel, Zbigniew Krasinski, Grzegorz Oszkinis, Fryderyk Pukacki, Maciej Slowinski, Michal-Goran Stanišic, Ryszard Staniszewski, Jolanta Tomczak, Maciej Zielinski, Piotr Myrcha, Dorota Rózanski, Stanislaw Drelichowski, Wojciech Iwanowski, Katarzyna Koncewicz, Pawel Bialek, Zbigniew Biejat, Wojciech Czepel, Anna Czlonkowska, Anatol Dowzenko, Julia Jedrzejewska, Adam Kobayashi, Jerzy Leszczynski, Andrzej Malek, Jerzy Polanski, Robert Proczka, Maciej Skorski, Mieczyslaw Szostek, Piotr Andziak, Maciej Dratwicki, Robert Gil, Miroslaw Nowicki, Jaroslaw Pniewski, Jaroslaw Rzezak, Piotr Seweryniak, Pawel Dabek, Michal Juszynski, Grzegorz Madycki, Bartosz Pacewski, Witold Raciborski, Piotr Slowinski, Walerian Staszkiewicz, Martin Bombic, Vladimír Chlouba, Jirí Fiedler, Karel Hes, Petr Koštál, Jindrich Sova, Zdenek Kríž, Mojmír Prívara, Michal Reif, Robert Staffa, Robert Vlachovský, Bohuslav Vojtíšek, Tomáš Hrbác, Martin Kuliha, Václav Procházka, Martin Roubec, David Školoudík, David Netuka, Anna Šteklácová, Vladimír Beneš III, Pavel Buchvald, Ladislav Endrych, Miroslav Šercl, Walter Campos Jr, Ivan B Casella, Nelson de Luccia, André E V Estenssoro, Calógero Presti, Pedro Puech-Leão, Celso R B Neves, Erasmo S da Silva, Cid J Sitrângulo Jr, José A T Monteiro, Gisela Tinone, Marcelo Bellini Dalio, Edwaldo E Joviliano, Octávio M Pontes Neto, Mauricio Serra Ribeiro, Patrick Cras, Jeroen M H Hendriks, Mieke Hoppenbrouwers, Patrick Lauwers, Caroline Loos, Laetitia Yperzeele, Mia Geenens, Dimitri Hemelsoet, Isabelle van Herzeele, Frank Vermassen, Parla Astarci, Frank Hammer, Valérie Lacroix, André Peeters, Robert Verhelst, Silvana Cirelli, Pol Dormal, Annelies Grimonprez, Bart Lambrecht, Philipe Lerut, Eddy Thues, Guy De Koster, Quentin Desiron, Alain Maertens de Noordhout, Danielle Malmendier, Mireille Massoz, Georges Saad, Marc Bosiers, Joren Callaert, Koen Deloose, Estrella Blanco Cañibano, Beatriz García Fresnillo, Mercedes Guerra Requena, Pilar C Morata Barrado, Miguel Muela Méndez, Antonio Yusta Izquierdo, Fernando Aparici Robles, Paula Blanes Orti, Luis García Dominguez, Rafael Martínez López, Manuel Miralles Hernández, José I Tembl Ferrairo, Ángel Chamorro, Juan Macho, Víctor Obach, Vincent Riambau, Luis San Román, Frank J Ahlhelm, Kristine Blackham, Stefan Engelter, Thomas Eugster, Henrik Gensicke, Lorenz Gürke, Philippe Lyrer, Luigi Mariani, Marina Maurer, Edin Mujagic, Mandy Müller, Marios Psychogios, Peter Stierli, Christoph Stippich, Christopher Traenka, Thomas Wolff, Benjamin Wagner, Martina M Wiegert, Sandra Clarke, Michael Diepers, Ernst Gröchenig, Philipp Gruber, Andrej Isaak, Timo Kahles, Regula Marti, Krassen Nedeltchev, Luca Remonda, Nadir Tissira, Martina Valença Falcão, Gert J de Borst, Rob H Lo, Frans L Moll, Raechel Toorop, Bart H van der Worp, Evert J Vonken, Jaap L Kappelle, Ommid Jahrome, Floris Vos, Wouter Schuiling, Hendrik van Overhagen, Rudolf W M Keunen, Bob Knippenberg, Jan J Wever, Jan W Lardenoije, Michel Reijnen, Luuk Smeets, Steven van Sterkenburg, Gustav Fraedrich, Elke Gizewski, Ingrid Gruber, Michael Knoflach, Stefan Kiechl, Barbara Rantner, Timur Abdulamit, Patrice Bergeron, Raymond Padovani, Jean-Christophe Trastour, Jean-Marie Cardon, Anne Le Gallou-Wittenberg, Eric Allaire, Jean-Pierre Becquemin, Frédéric Cochennec-Paliwoda, Pascal Desgranges, Hassan Hosseini, Hicham Kobeiter, Jean Marzelle, Mohammed A Almekhlafi, Simerpreet Bal, Phillip A Barber, Shelagh B Coutts, Andrew M Demchuk, Muneer Eesa, Michelle Gillies, Mayank Goyal, Michael D Hill, Mark E Hudon, Anitha Jambula, Carol Kenney, Gary Klein, Marie McClelland, Alim Mitha, Bijoy K Menon, William F Morrish, Steven Peters, Karla J Ryckborst, Greg Samis, Supriya Save, Eric E Smith, Peter Stys, Suresh Subramaniam, Garnette R Sutherland, Tim Watson, John H Wong, L Zimmel, Vojko Flis, Jože Matela, Kazimir Miksic, Franko Milotic, Božidar Mrdja, Barbara Stirn, Erih Tetickovic, Mladen Gasparini, Anton Grad, Ingrid Kompara, Zoren Miloševic, Veronika Palmiste, Toomas Toomsoo, Balzhan Aidashova, Nursultan Kospanov, Roman Lyssenko, Daulet Mussagaliev, Rafi Beyar, Aaron Hoffman, Tony Karram, Arthur Kerner, Eugenia Nikolsky, Samy Nitecki, Silva Andonova, Chavdar Bachvarov, Vesko Petrov, Ivan Cvjetko, Vinko Vidjak, Damir Halužan, Mladen Petrunic, Bao Liu, Chang-Wei Liu, Daniel Bartko, Peter Beno, František Rusnák, Kamil Zelenák, Masayuki Ezura, Takashi Inoue, Naoto Kimura, Ryushi Kondo, Yasushi Matsumoto, Hiroaki Shimizu, Hidenori Endo, Eisuke Furui, Søren Bakke, Kristen Krohg-Sørensen, Terje Nome, Mona Skjelland, Bjørn Tennøe, João Albuquerque e Castro, Gonçalo Alves, Frederico Bastos Gonçalves, José de Aragão Morais, Ana C Garcia, Hugo Valentim, Leonor Vasconcelos, Fernando Belcastro, Fernando Cura, Patricio Zaefferer, Foad Abd-Allah, Mohamed H Eldessoki, Hussein Heshmat Kassem, Haytham Soliman Gharieb, Mary P Colgan, Syed N Haider, Joe Harbison, Prakash Madhavan, Dermot Moore, Gregor Shanik, Viviane Kazan, Munier Nazzal, Vicki Ramsey-Williams, ACST-2 Collaborative Group, Group, ACST-2 Collaborative, Halliday A., Bulbulia R., Bonati L.H., Chester J., Cradduck-Bamford A., Peto R., Pan H., Potter J., Henning Eckstein H., Farrell B., Flather M., Mansfield A., Mihaylova B., Rahimi K., Simpson D., Thomas D., Sandercock P., Gray R., Molyneux A., Shearman C.P., Rothwell P., Belli A., Herrington W., Judge P., Leopold P., Mafham M., Gough M., Cao P., MacDonald S., Bari V., Berry C., Bradshaw S., Brudlo W., Clarke A., Cox R., Fathers S., Gaba K., Gray M., Hayter E., Holliday C., Kurien R., Lay M., le Conte S., McManus J., Madgwick Z., Morris D., Munday A., Pickworth S., Ostasz W., Poorthuis M., Richards S., Teixeira L., Tochlin S., Tully L., Wallis C., Willet M., Young A., Casana R., Malloggi C., Odero A., Silani V., Parati G., Malchiodi G., Malferrari G., Strozzi F., Tusini N., Vecchiati E., Coppi G., Lauricella A., Moratto R., Silingardi R., Veronesi J., Zini A., Ferrero E., Ferri M., Gaggiano A., Labate C., Nessi F., Psacharopulo D., Viazzo A., Malacrida G., Mazzaccaro D., Meola G., Modafferi A., Nano G., Occhiuto M.T., Righini P., Stegher S., Chiarandini S., Griselli F., Lepidi S., Pozzi Mucelli F., Naccarato M., D'Oria M., Ziani B., Stella A., Dieng M., Faggioli G., Gargiulo M., Palermo S., Pini R., Puddu G.M., Vacirca A., Angiletta D., Desantis C., Marinazzo D., Mastrangelo G., Regina G., Pulli R., Bianchi P., Cireni L., Coppi E., Pizzirusso R., Scalise F., Sorropago G., Tolva V., Caso V., Cieri E., DeRango P., Farchioni L., Isernia G., Lenti M., Parlani G.B., Pupo G., Pula G., Simonte G., Verzini F., Carimati F., Delodovici M.L., Fontana F., Piffaretti G., Tozzi M., Civilini E., Poletto G., Reimers B., Praquin B., Ronchey S., Capoccia L., Mansour W., Sbarigia E., Speziale F., Sirignano P., Toni D., Galeotti R., Gasbarro V., Mascoli F., Rocca T., Tsolaki E., Bernardini G., DeMarco E., Giaquinta A., Patti F., Veroux M., Veroux P., Virgilio C., Mangialardi N., Orrico M., Di Lazzaro V., Montelione N., Spinelli F., Stilo F., Cernetti C., Irsara S., Maccarrone G., Tonello D., Visona A., Zalunardo B., Chisci E., Michelagnoli S., Troisi N., Masato M., Dei Negri M., Pacchioni A., Sacca S., Amatucci G., Cannizzaro A., Accrocca F., Ambrogi C., Barbazza R., Marcucci G., Siani A., Bajardi G., Savettieri G., Argentieri A., Corbetta R., Quaretti P., Thyrion F.Z., Cappelli A., Benevento D., De Donato G., Mele M.A., Palasciano G., Pieragalli D., Rossi A., Setacci C., Setacci F., Palombo D., Perfumo M.C., Martelli E., Paolucci A., Trimarchi S., Grassi V., Grimaldi L., La Rosa G., Mirabella D., Scialabba M., Sichel L., D'Angelo C.L., Fadda G.F., Kasemi H., Marino M., Burzotta F., Codispoti F.A., Ferrante A., Tinelli G., Tshomba Y., Vincenzoni C., Amis D., Anderson D., Catterson M., Clarke M., Davis M., Dixit A., Dyker A., Ford G., Jackson R., Kappadath S., Lambert D., Lees T., Louw S., McCaslin J., Parr N., Robson R., Stansby G., Wales L., Wealleans V., Wilson L., Wyatt M., Baht H., Balogun I., Burger I., Cosier T., Cowie L., Gunathilagan G., Hargroves D., Insall R., Jones S., Rudenko H., Schumacher N., Senaratne J., Thomas G., Thomson A., Webb T., Brown E., Esisi B., Mehrzad A., MacSweeney S., McConachie N., Southam A., Sunman W., Abdul-Hamiq A., Bryce J., Chetter I., Ettles D., Lakshminarayan R., Mitchelson K., Rhymes C., Robinson G., Scott P., Vickers A., Ashleigh R., Butterfield S., Gamble E., Ghosh J., McCollum C.N., Welch M., Welsh S., Wolowczyk L., Donnelly M., D'Souza S., Egun A.A., Gregary B., Joseph T., Kelly C., Punekar S., Rahi M.A., Raj S., Seriki D., Thomson G., Brown J., Durairajan R., Grunwald I., Guyler P., Harman P., Jakeways M., Khuoge C., Kundu A., Loganathan T., Menon N., Prabakaran R.O., Sinha D., Thompson V., Tysoe S., Briley D., Darby C., Hands L., Howard D., Kuker W., Schulz U., Teal R., Barer D., Brown A., Crawford S., Dunlop P., Krishnamurthy R., Majmudar N., Mitchell D., Myint M.P., O'Brien R., O'Connell J., Sattar N., Vetrivel S., Beard J., Cleveland T., Gaines P., Humphreys J., Jenkins A., King C., Kusuma D., Lindert R., Lonsdale R., Nair R., Nawaz S., Okhuoya F., Turner D., Venables G., Dorman P., Hughes A., Jones D., Mendelow D., Rodgers H., Raudoniitis A., Enevoldson P., Nahser H., O'Brien I., Torella F., Watling D., White R., Brown P., Dutta D., Emerson L., Hilltout P., Kulkarni S., Morrison J., Poskitt K., Slim F., Smith S., Tyler A., Waldron J., Whyman M., Bajoriene M., Baker L., Colston A., Eliot-Jones B., Gramizadeh G., Lewis-Clarke C., McCafferty L., Oliver D., Palmer D., Patil A., Pegler S., Ramadurai G., Roberts A., Sargent T., Siddegowda S., Singh-Ranger R., Williams A., Williams L., Windebank S., Zuromskis T., Alwis L., Angus J., Asokanathan A., Fornolles C., Hardy D., Hunte S., Justin F., Phiri D., Mitabouana-Kibou M., Sekaran L., Sethuraman S., Tate M.L., Akyea-Mensah J., Ball S., Chrisopoulou A., Keene E., Phair A., Rogers S., Smyth J.V., Bicknell C., Chataway J., Cheshire N., Clifton A., Eley C., Gibbs R., Hamady M., Hazel B., James A., Jenkins M., Khanom N., Lacey A., Mireskandari M., O'Reilly J., Pereira A., Sachs T., Wolfe J., Davey P., Rogers G., Smith G., Tervit G., Nichol I., Parry A., Young G., Ashley S., Barwell J., Dix F., Nor A.M., Parry C., Birt A., Davies P., George J., Graham A., Jonker L., Kelsall N., Potts C., Wilson T., Crinnion J., Cuenoud L., Aleksic N., Babic S., Ilijevski N., Radak, Sagic D., Tanaskovic S., Colic M., Cvetic V., Davidovic L., Jovanovic D.R., Koncar I., Mutavdzic P., Sladojevic M., Tomic I., Debus E.S., Grzyska U., Otto D., Thomalla G., Barlinn J., Gerber J., Haase K., Hartmann C., Ludwig S., Putz V., Reeps C., Schmidt C., Weiss N., Werth S., Winzer S., Gemper J., Gunther A., Heiling B., Jochmann E., Karvouniari P., Klingner C., Mayer T., Schubert J., Schulze-Hartung F., Zanow J., Bausback Y., Borger F., Botsios S., Branzan D., Braunlich S., Holzer H., Lenzer J., Piorkowski C., Richter N., Schuster J., Scheinert D., Schmidt A., Staab H., Ulrich M., Werner M., Berger H., Biro G., Eckstein H.-H., Kallmayer M., Kreiser K., Zimmermann A., Berekoven B., Frerker K., Gordon V., Torsello G., Arnold S., Dienel C., Storck M., Biermaier B., Gissler H.M., Klotzsch C., Pfeiffer T., Schneider R., Sohl L., Wennrich M., Alonso A., Keese M., Groden C., Coster A., Engelhardt A., Ratusinski C.-M., Berg B., Delle M., Formgren J., Gillgren P., Jarl L., Kall T.B., Konrad P., Nyman N., Skioldebrand C., Steuer J., Takolander R., Malmstedt J., Acosta S., Bjorses K., Brandt K., Dias N., Gottsater A., Holst J., Kristmundsson T., Kuhme T., Kolbel T., Lindblad B., Lindh M., Malina M., Ohrlander T., Resch T., Ronnle V., Sonesson B., Warvsten M., Zdanowski Z., Campbell E., Kjellin P., Lindgren H., Nyberg J., Petersen B., Plate G., Parsson H., Qvarfordt P., Ignatenko P., Karpenko A., Starodubtsev V., Chernyavsky M.A., Golovkova M.S., Komakha B.B., Zherdev N.N., Belyasnik A., Chechulov P., Kandyba D., Stepanishchev I., Csobay-Novak C., Dosa E., Entz L., Nemes B., Szeberin Z., Barzo P., Bodosi M., Fako E., Fulop B., Nemeth T., Pazdernyik S., Skoba K., Voros E., Chatzinikou E., Giannoukas A., Karathanos C., Koutsias S., Kouvelos G., Matsagkas M., Ralli S., Rountas C., Rousas N., Spanos K., Brountzos E., Kakisis J.D., Lazaris A., Moulakakis K.G., Stefanis L., Tsivgoulis G., Vasdekis S., Antonopoulos C.N., Bellenis I., Maras D., Polydorou A., Polydorou V., Tavernarakis A., Ioannou N., Terzoudi M., Lazarides M., Mantatzis M., Vadikolias K., Dzieciuchowicz L., Gabriel M., Krasinski Z., Oszkinis G., Pukacki F., Slowinski M., Stanisic M.-G., Staniszewski R., Tomczak J., Zielinski M., Myrcha P., Rozanski D., Drelichowski S., Iwanowski W., Koncewicz K., Bialek P., Biejat Z., Czepel W., Czlonkowska A., Dowzenko A., Jedrzejewska J., Kobayashi A., Leszczynski J., Malek A., Polanski J., Proczka R., Skorski M., Szostek M., Andziak P., Dratwicki M., Gil R., Nowicki M., Pniewski J., Rzezak J., Seweryniak P., Dabek P., Juszynski M., Madycki G., Pacewski B., Raciborski W., Slowinski P., Staszkiewicz W., Bombic M., Chlouba V., Fiedler J., Hes K., Kostal P., Sova J., Kriz Z., Privara M., Reif M., Staffa R., Vlachovsky R., Vojtisek B., Hrbac T., Kuliha M., Prochazka V., Roubec M., Skoloudik D., Netuka D., Steklacova A., Benes III V., Buchvald P., Endrych L., Sercl M., Campos W., Casella I.B., de Luccia N., Estenssoro A.E.V., Presti C., Puech-Leao P., Neves C.R.B., da Silva E.S., Sitrangulo C.J., Monteiro J.A.T., Tinone G., Bellini Dalio M., Joviliano E.E., Pontes Neto O.M., Serra Ribeiro M., Cras P., Hendriks J.M.H., Hoppenbrouwers M., Lauwers P., Loos C., Yperzeele L., Geenens M., Hemelsoet D., van Herzeele I., Vermassen F., Astarci P., Hammer F., Lacroix V., Peeters A., Verhelst R., Cirelli S., Dormal P., Grimonprez A., Lambrecht B., Lerut P., Thues E., De Koster G., Desiron Q., Maertens de Noordhout A., Malmendier D., Massoz M., Saad G., Bosiers M., Callaert J., Deloose K., Blanco Canibano E., Garcia Fresnillo B., Guerra Requena M., Morata Barrado P.C., Muela Mendez M., Yusta Izquierdo A., Aparici Robles F., Blanes Orti P., Garcia Dominguez L., Martinez Lopez R., Miralles Hernandez M., Tembl Ferrairo J.I., Chamorro A., Macho J., Obach V., Riambau V., San Roman L., Ahlhelm F.J., Blackham K., Engelter S., Eugster T., Gensicke H., Gurke L., Lyrer P., Mariani L., Maurer M., Mujagic E., Muller M., Psychogios M., Stierli P., Stippich C., Traenka C., Wolff T., Wagner B., Wiegert M.M., Clarke S., Diepers M., Grochenig E., Gruber P., Isaak A., Kahles T., Marti R., Nedeltchev K., Remonda L., Tissira N., Valenca Falcao M., de Borst G.J., Lo R.H., Moll F.L., Toorop R., van der Worp B.H., Vonken E.J., Kappelle J.L., Jahrome O., Vos F., Schuiling W., van Overhagen H., Keunen R.W.M., Knippenberg B., Wever J.J., Lardenoije J.W., Reijnen M., Smeets L., van Sterkenburg S., Fraedrich G., Gizewski E., Gruber I., Knoflach M., Kiechl S., Rantner B., Abdulamit T., Bergeron P., Padovani R., Trastour J.-C., Cardon J.-M., Le Gallou-Wittenberg A., Allaire E., Becquemin J.-P., Cochennec-Paliwoda F., Desgranges P., Hosseini H., Kobeiter H., Marzelle J., Almekhlafi M.A., Bal S., Barber P.A., Coutts S.B., Demchuk A.M., Eesa M., Gillies M., Goyal M., Hill M.D., Hudon M.E., Jambula A., Kenney C., Klein G., McClelland M., Mitha A., Menon B.K., Morrish W.F., Peters S., Ryckborst K.J., Samis G., Save S., Smith E.E., Stys P., Subramaniam S., Sutherland G.R., Watson T., Wong J.H., Zimmel L., Flis V., Matela J., Miksic K., Milotic F., Mrdja B., Stirn B., Tetickovic E., Gasparini M., Grad A., Kompara I., Milosevic Z., Palmiste V., Toomsoo T., Aidashova B., Kospanov N., Lyssenko R., Mussagaliev D., Beyar R., Hoffman A., Karram T., Kerner A., Nikolsky E., Nitecki S., Andonova S., Bachvarov C., Petrov V., Cvjetko I., Vidjak V., Haluzan D., Petrunic M., Liu B., Liu C.-W., Bartko D., Beno P., Rusnak F., Zelenak K., Ezura M., Inoue T., Kimura N., Kondo R., Matsumoto Y., Shimizu H., Endo H., Furui E., Bakke S., Krohg-Sorensen K., Nome T., Skjelland M., Tennoe B., Albuquerque e Castro J., Alves G., Bastos Goncalves F., de Aragao Morais J., Garcia A.C., Valentim H., Vasconcelos L., Belcastro F., Cura F., Zaefferer P., Abd-Allah F., Eldessoki M.H., Heshmat Kassem H., Soliman Gharieb H., Colgan M.P., Haider S.N., Harbison J., Madhavan P., Moore D., Shanik G., Kazan V., Nazzal M., Ramsey-Williams V., and Gargiulo M
Subjects: Male, medicine.medical_specialty, Time Factors, Time Factor, medicine.medical_treatment, Carotid Stenosi, MEDLINE, Carotid endarterectomy, Rate ratio, Risk Assessment, Asymptomatic, law.invention, Randomized controlled trial, law, Risk Factors, carotid artery stenting (CAS), carotid endarterectomy (CEA), Stent, medicine, Humans, Carotid Stenosis, Stroke, Endarterectomy, Aged, Endarterectomy, Carotid, business.industry, carotid artery, Risk Factor, Articles, General Medicine, trial, medicine.disease, Settore MED/22 - CHIRURGIA VASCOLARE, Surgery, Stenosis, Treatment Outcome, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Female, Stents, Human medicine, medicine.symptom, business, Human
Abstract: Summary Background Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding UK Medical Research Council and Health Technology Assessment Programme.
Published: 2021

24. Reducing chronic stress to promote health in adults: the role of social prescriptions and social movements

Author: Anant Jani, Giovanna Adamo, William Bird, Muir Gray, and Erica Pitini
Subjects: Adult, medicine.medical_specialty, business.industry, Disease Management, Social Support, General Medicine, Health Promotion, Surveys and Questionnaires, Chronic Disease, Medicine, Humans, Chronic stress, Medical prescription, business, Psychiatry, Stress, Psychological, Series, Social movement
Published: 2023

25. Tuberculosis Screening in Silica-Exposed Workers : Developing a Tool for Health Care Providers

Author: Margaret A Leland, Barbara Burchell Braid, Nicholas K Reul, and Zachary Gray
Subjects: Adult, medicine.medical_specialty, Medical surveillance, Tuberculosis, Latent tuberculosis, Public Health Methodology, business.industry, Public health, Health Personnel, Public Health, Environmental and Occupational Health, Disease, Tuberculosis screening, medicine.disease, Silicon Dioxide, Occupational safety and health, Latent Tuberculosis, Family medicine, Occupational Exposure, Health care, medicine, Humans, business, Occupational Health
Abstract: Both the Occupational Safety and Health Administration and Washington State require safety and health protections for workers exposed to respirable crystalline silica, including tuberculosis (TB) screening as part of occupational medical surveillance. We describe the creation of a TB screening tool for silica-exposed workers receiving regulated medical surveillance examinations in Washington State. The tool provides relevant clinical recommendations to assist health care providers and public health practitioners who choose to use the tool when performing such examinations. A cross-disciplinary team at the Washington State Department of Labor and Industries created the TB screening tool to help health care providers identify silica-exposed workers who should receive a comprehensive evaluation for active TB disease and workers who should or must receive testing for latent TB infection. The Washington State Adult Tuberculosis Screening Tool for Workers Exposed to Respirable Crystalline Silica benefits occupational and respiratory clinicians and public health practitioners by aiding both the individual- and population-level delivery of occupational health and TB screening services to silica-exposed workers receiving required medical surveillance examinations.
Published: 2023

26. Complicated spontaneous pneumoparotid mimicking a neck mass in a child with Down’s syndrome

Author: Sheree C. Gray, Zelia Sofianos, Jacobus A. Pienaar, and Jacob Varghese
Subjects: Insufflation, lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, lcsh:R895-920, Neck mass, Computed tomography, Case Report, Oral cavity, Medicine, Radiology, Nuclear Medicine and imaging, Pneumoparotid, Paediatric population, S syndrome, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Spontaneous, Self-induced pneumoparotid, medicine.anatomical_structure, Stensen’s duct, Radiology, medicine.symptom, business, Duct (anatomy)
Abstract: Spontaneous or self-induced pneumoparotid, which usually manifests as acute unilateral gland enlargement, is caused by insufflation of air from the oral cavity via Stensen's duct. A 9-year-old patient, with known Down's syndrome, presented with a progressively enlarging, painless, spontaneous, left neck mass. Computed tomography showed features consistent with pneumoparotid, without underlying associated pathology. Identification of true cases of spontaneous pneumoparotid is crucial, as these require a holistic management approach to prevent recurrence and complications.
Published: 2023

27. Telemedicine for Gestational Diabetes Mellitus (TeleGDM): A Mixed-Method Study Protocol of Effects of a Web-Based GDM Support System on Health Service Utilization, Maternal and Fetal Outcomes, Costs, and User Experience

Author: Kathleen Gray, John Furler, Kwang Lim, Tshepo Rasekaba, and Irene Blackberry
Subjects: medicine.medical_specialty, Telemedicine, electronic personal health record, 020205 medical informatics, Birth weight, Population, Psychological intervention, 030209 endocrinology & metabolism, 02 engineering and technology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Nursing, law, 0202 electrical engineering, electronic engineering, information engineering, Protocol, Medicine, education, Uncategorized, education.field_of_study, Internet, Self-management, business.industry, General Medicine, medicine.disease, Clinical trial, Gestational diabetes, Family medicine, telemedicine, gestational diabetes, business
Abstract: Background: Women with insulin-treated gestational diabetes mellitus (GDM) require close monitoring and support to manage their diabetes. Recent changes to the diagnostic criteria have implications for service provision stemming from increased prevalence, suggesting an increased burden on health services in the future. Telemedicine may augment usual care and mitigate service burdens without compromising clinical outcomes but evidence in GDM is limited. Objective: The Telemedicine for Gestational Diabetes Mellitus (TeleGDM) trial aims to explore the use of telemedicine in supporting care and management of women with GDM treated with insulin. Methods: The TeleGDM is a mixed-methods study comprising an exploratory randomized controlled trial (RCT) and a qualitative evaluation using semistructured interviews. It involves women with insulin-treated GDM who are up to 35 weeks gestation. Participating patients (n=100) are recruited face-to-face in outpatient GDM clinics at an outer metropolitan tertiary hospital with a culturally diverse catchment and a regional tertiary hospital. The second group of participants (n=8) comprises Credentialed Diabetes Educator Registered Nurses involved in routine care of the women with GDM at the participating clinics. The RCT involves use of a Web-based patient-controlled personal health record for GDM data sharing between patients and clinicians compared to usual care. Outcomes include service utilization, maternal and fetal outcomes (eg, glycemic control, 2nd and 3rd trimester fetal size, type of delivery, baby birth weight), diabetes self-efficacy, satisfaction, and costs. Semistructured interviews will be used to examine user experiences and acceptability of telemedicine. Results: The trial recruitment is currently underway. Results are expected by the end of 2016 and will be reported in a follow-up paper. Conclusions: Innovative use of technology in supporting usual care delivery in women with GDM may facilitate timely access to GDM monitoring data and mitigate care burdens without compromising maternal and fetal outcomes. The intervention may potentially reduce health service utilization. Trial Registration: Australian and New Zealand Clinical Trials Registry (ANZCTR): ACTRN12614000934640; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=366740 (Archived by WebCite® at http://www.webcitation.org/6jRiqzjSv).
Published: 2023
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28. Controlled ecological evaluation of an implemented exercise-training programme to prevent lower limb injuries in sport: population-level trends in hospital-treated injuries

Author: Muhammad Akram, Shannon Gray, David Lloyd, Jill Cook, Alex Donaldson, and Caroline F. Finch
Subjects: Program evaluation, Adult, Male, medicine.medical_specialty, Population level, Adolescent, Victoria, injury prevention, Physical Therapy, Sports Therapy and Rehabilitation, Football, Lower limb, law.invention, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Randomized controlled trial, law, 11. Sustainability, Epidemiology, Injury prevention, Soccer, medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Young adult, implementation, Uncategorized, Ecology, business.industry, 030229 sport sciences, General Medicine, Middle Aged, Athletic Injuries, Original Article, business, exercise training, Leg Injuries, Physical Conditioning, Human, Program Evaluation
Abstract: ObjectiveExercise-training programmes have reduced lower limb injuries in trials, but their population-level effectiveness has not been reported in implementation trials. This study aimed to demonstrate that routinely collected hospital data can be used to evaluate population-level programme effectiveness.MethodA controlled ecological design was used to evaluate the effect of FootyFirst, an exercise-training programme, on the number of hospital-treated lower limb injuries sustained by males aged 16–50 years while participating in community-level Australian Football. FootyFirst was implemented with ‘support’ (FootyFirst+S) or ‘without support’ (FootyFirst+NS) in different geographic regions of Victoria, Australia: 22 clubs in region 1: FootyFirst+S in 2012/2013; 25 clubs in region 2: FootyFirst+NS in 2012/2013; 31 clubs region 3: control in 2012, FootyFirst+S in 2013. Interrupted time-series analysis compared injury counts across regions and against trends in the rest of Victoria.ResultsAfter 1 year of FootyFirst+S, there was a non-statistically significant decline in the number of lower limb injuries in region 1 (2012) and region 3 (2013); this was not maintained after 2 years in region 1. Compared with before FootyFirst in 2006–2011, injury count changes at the end of 2013 were: region 1: 20.0% reduction (after 2 years support); region 2: 21.5% increase (after 2 years without support); region 3: 21.8% increase (after first year no programme, second year programme with support); rest of Victoria: 12.6% increase.ConclusionEcological analyses using routinely collected hospital data show promise as the basis of population-level programme evaluation. The implementation and sustainability of sports injury prevention programmes at the population-level remains challenging.
Published: 2023
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29. Quality of Life in Men With Prostate Cancer Randomly Allocated to Receive Docetaxel or Abiraterone in the STAMPEDE Trial

Author: Ruth E Langley, David P. Dearnaley, H. Rush, Silke Gillessen, Mahesh K. B. Parmar, Andrew Protheroe, Robin Millman, Shaun Tolan, Zaf Malik, Peter Hoskin, Christopher D. Brawley, Duncan C. Gilbert, Simon Chowdhury, Noel W. Clarke, Sarah Rudman, Nicholas D. James, Carla Perna, Neil McPhail, J. Martin Russell, Robert Jones, John Wagstaff, Adrian Cook, Gerhardt Attard, Joanna Gale, Salil Vengalil, Emma Gray, Alison Birtle, David Gareth Fackrell, Jacob Tanguay, Matthew R. Sydes, Archie Macnair, Joe M. O'Sullivan, Chris Parker, Alicia K. Morgans, Laura Murphy, David Matheson, and C. Pugh
Subjects: Male, Oncology, Cancer Research, medicine.medical_specialty, Abiraterone Acetate, Docetaxel, Article, Androgen deprivation therapy, chemistry.chemical_compound, Prostate cancer, Quality of life, Prednisone, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, otorhinolaryngologic diseases, Humans, Medicine, business.industry, Abiraterone acetate, Prostatic Neoplasms, Androgen Antagonists, medicine.disease, Abiraterone, chemistry, Quality of Life, Prednisolone, Androstenes, business, medicine.drug
Abstract: PURPOSE Docetaxel and abiraterone acetate plus prednisone or prednisolone (AAP) both improve survival when commenced alongside standard of care (SOC) androgen deprivation therapy in locally advanced or metastatic hormone-sensitive prostate cancer. Thus, patient-reported quality of life (QOL) data may guide treatment choices. METHODS A group of patients within the STAMPEDE trial were contemporaneously enrolled with the possibility of being randomly allocated to receive either docetaxel + SOC or AAP + SOC. A mixed-model assessed QOL in those who had completed at least one QLQ-C30 + PR25 questionnaire. The primary outcome measure was difference in global-QOL (QLQ-C30 Q29&30) between patients allocated to docetaxel + SOC or AAP + SOC over the 2 years after random assignment, with a predefined criterion for clinically meaningful difference of > 4.0 points. Secondary outcome measures included longitudinal comparison of functional domains, pain, and fatigue, plus global-QOL at defined timepoints. RESULTS Five hundred fifteen patients (173 docetaxel + SOC and 342 AAP + SOC) were included. Baseline characteristics, proportion of missing data, and mean baseline global-QOL scores (docetaxel + SOC 77.8 and AAP + SOC 78.0) were similar. Over the 2 years following random assignment, the mean modeled global-QOL score was +3.9 points (95% CI, +0.5 to +7.2; P = .022) higher in patients allocated to AAP + SOC. Global-QOL was higher for patients allocated to AAP + SOC over the first year (+5.7 points, 95% CI, +3.0 to +8.5; P < .001), particularly at 12 (+7.0 points, 95% CI, +3.0 to +11.0; P = .001) and 24 weeks (+8.3 points, 95% CI, +4.0 to +12.6; P < .001). CONCLUSION Patient-reported QOL was superior for patients allocated to receive AAP + SOC, compared with docetaxel + SOC over a 2-year period, narrowly missing the predefined value for clinical significance. Patients receiving AAP + SOC reported clinically meaningful higher global-QOL scores throughout the first year following random assignment.
Published: 2022

30. Debris collision mitigation from the ground using laser guide star adaptive optics at mount Stromlo observatory

Author: Elliott Thorn, Noelia Martinez, John Hart, Marcus Lingham, M Blundell, Ian Price, Schofield W, Gray A, Fetzer G, Antony Galla, James Webb, Doris Grosse, Yue Gao, Chan A, Yanjie Wang, Michael Copeland, Steve Rako, Craig Smith, and Celine d'Orgeville
Subjects: Physics, business.industry, Aerospace Engineering, Laser, law.invention, Telescope, Laser guide star, Observatory, law, Guide star, Aerospace engineering, Safety, Risk, Reliability and Quality, Adaptive optics, business, Space debris, Space environment
Abstract: The Australian National University (ANU) and industry partners EOS Space Systems and Lockheed Martin are part of the Space Environment Research Centre (SERC), an Australian-Government funded cooperative research centre headquartered in Canberra, Australia. SERC aims to mitigate the threat of collisions with space debris using a ground-based high power (10-20kW) infrared (IR) laser to modify the debris orbit should a collision be predicted. To that end, the ANU has equipped the EOS 1.8m laser tracking station telescope on the ANU Mount Stromlo campus with a state-of-the-art Laser Guide Star Adaptive Optics (LGS AO) system to pre-compensate the IR laser prior to propagation through earth's atmosphere. The ANU LGS AO system is currently being integrated with the EOS telescope and the high-power IR laser. This paper provides a brief overview of the LGS AO system and focus more specifically on the design, integration and commissioning of the first LGS facility ever constructed in Australia. The LGS Facility includes two sodium guide star laser sources which can be either propagated separately or combined so as to produce a brighter reference star to maximise adaptive optics correction. The two lasers, their beam combining optics, their common beam transfer optics, and the laser launch telescope are hereby described.
Published: 2022

31. Macrophages from gut-corrected CF mice express human CFTR and lack a pro-inflammatory phenotype

Author: Jonathan L Gillan, Donald J. Davidson, Robert D. Gray, and Gareth Hardisty
Subjects: Pulmonary and Respiratory Medicine, Cystic Fibrosis, Transgene, Cystic Fibrosis Transmembrane Conductance Regulator, Inflammation, Disease, Cystic fibrosis, Mice, Immune system, Animal model, medicine, Animals, Humans, Mice, Inbred CFTR, business.industry, Macrophages, medicine.disease, Phenotype, Pathophysiology, Intestines, Disease Models, Animal, Pediatrics, Perinatology and Child Health, Immunology, medicine.symptom, business
Abstract: Macrophages represent prominent immune orchestrators of cystic fibrosis (CF) inflammation and, as such, are an ever-increasing focus of CF research with several reports of intrinsic immune dysfunction related to loss of CFTR activity in macrophages themselves. Animal models of CF have contributed, in no small part, to a deepening of our understanding of the pathophysiology of the disease and towards therapeutic development. A commonly-used animal model in CF research is the Cftrtm1Unc Tg(FABP-hCFTR) mouse, which displays gut-specific expression of a human CFTR transgene in order to rescue the high rate of early mortality in Cftr-null mice associated with severe intestinal obstruction. We find significant variation in the response to inflammatory challenge of patient macrophages and cells derived from the Cftrtm1Unc Tg(FABP-hCFTR) mouse and show that macrophages derived from this mouse exhibit aberrant expression of human CFTR. This may contribute to the absence of inflammatory changes in this model.
Published: 2022

32. Annular scaly plaques with peripheral pustules

Author: Taylor Gray, Lisa Fronek, Julie D. Gibbs, James Sligh, and Allyson Brahs
Subjects: Pathology, medicine.medical_specialty, business.industry, medicine, Dermatology, business, JDCR Case challenge, Peripheral
Published: 2022

33. A Framework for Anti-Racist Publication in Palliative Care: Structures, Processes, and Outcomes

Author: Bukiwe Sihlongonyane, Justin J. Sanders, Brigitte N. Durieux, Tamryn F. Gray, and Leigh Graham
Subjects: medicine.medical_specialty, Palliative care, business.industry, media_common.quotation_subject, Palliative Care, Equity (finance), Public relations, Racism, Hospice and palliative medicine, Scholarship, Anesthesiology and Pain Medicine, Social Justice, Publishing, Health care, Ethnicity, Humans, Medicine, Neurology (clinical), business, Minority Groups, General Nursing, Disadvantage, media_common
Abstract: Systemic or structural racism describes an embedded pattern of explicit and implicit racial biases that, through policy and action, systematically confer advantage to white people and disadvantage Black, indigenous, and other people of color. Hospice and palliative care journals participate in this broader system of racial discrimination. Building on palliative care's explicit focus on patients' goals and values, which may in and of itself comprise a form of social justice in healthcare, palliative care journals and their publishers have an opportunity to lead others in cultivating anti-racist practices and explicitly promoting equity. The publication life cycle of submission and solicitation, manuscript peer-review, and publication provide a framework for examining the structures, processes, and outcomes by which palliative care and other journals might address systemic racism. We describe the current academic publishing landscape, which diminishes the voices and experiences of racial and ethnic minority patients and undermines the careers of under-represented scholars. We then propose reforms that we believe will improve publication equity and quality as well as healthcare outcomes. These include an Equity in Publication checklist, solicitation of manuscripts on equity-relevant topics, promotion of scholars through editorial structures and peer review processes, and a standard Equity Rating for publications. Greater efforts to include non-dominant voices in every aspect of publication, through appropriate recognition of their scholarship and remuneration for their efforts, will drive equity in health outcomes. By pursuing an anti-racist and equity-focused publishing agenda, hospice and palliative medicine journals and their publishers have an opportunity to transform healthcare.
Published: 2022

34. Biomarkers in Unstable Carotid Plaque: Physiopathology and Prediction

Author: Giovambattista De Sarro, Sean M. Murphy, Antonio Siniscalchi, Luca Gallelli, and Cleona Gray
Subjects: Carotid Artery Diseases, medicine.medical_specialty, Cochrane Library, medicine.disease_cause, Drug treatment, Risk Factors, Carotid artery disease, Internal medicine, Humans, Medicine, Stroke, Pharmacology, business.industry, Hematology, medicine.disease, Vulnerable plaque, Inflammatory biomarkers, Plaque, Atherosclerotic, Pathophysiology, Stenosis, Carotid Arteries, Cardiology, Cardiology and Cardiovascular Medicine, business, Biomarkers
Abstract: Aims: To study the role of cytokines and vascular inflammatory biomarkers in unstable carotid plaque Background: Clinical studies showed that not only the degree of stenosis but also the type of carotid plaque can be responsible for ipsilateral ischemic stroke. Objective: The objective of this study is to suggest a role for vulnerable carotid atherosclerotic disease in the occurrence of ischemic stroke. Methods: PubMed, Embase, Cochrane library, and reference lists have been used to evaluate articles published until February 15, 2021. Results: Several factors may be involved in unstable plaque. Clinical studies support the involvement of brain inflammatory biomarkers as well as cytokines in the unstable carotid plaque. Conclusions: Biomarkers could help to stratify patients with a vulnerable carotid plaque and to personalize the drug treatment. In this review, we briefly discuss the characteristics of vulnerable plaque and the role of biomarkers in the vulnerable carotid plaque.
Published: 2022

35. Immune response to <scp>COVID</scp> ‐19 vaccination is attenuated by poor disease control and antimyeloma therapy with vaccine driven divergent T‐cell response

Author: Karthik Ramasamy, Ross Sadler, Sally Jeans, Paul Weeden, Sherin Varghese, Alison Turner, Jemma Larham, Nathanael Gray, Oluremi Carty, Joe Barrett, Stella Bowcock, Udo Oppermann, Gordon Cook, Chara Kyriakou, Mark Drayson, Supratik Basu, Sally Moore, Sarah McDonald, Sarah Gooding, and Muhammad K Javaid
Subjects: Adult, Male, COVID-19 Vaccines, T-Lymphocytes, Interferon gamma release assay, Antibodies, Viral, Serology, Immune system, Medicine, Humans, Clinical significance, Prospective Studies, Prospective cohort study, BNT162 Vaccine, business.industry, SARS-CoV-2, Vaccination, COVID-19, Hematology, Immunity, Humoral, Regimen, Immunology, Smouldering myeloma, business, Multiple Myeloma
Abstract: SummaryBackgroundMyeloma patients frequently respond poorly to bacterial and viral vaccination. A few studies have reported poor humoral immune responses in myeloma patients to COVID-19 vaccination.MethodsUsing a prospective study of myeloma patients in UK Rudy Study cohort, we assessed humoral and Interferon gamma release assay (IGRA) cellular immune responses to COVID-19 vaccination post second COVID-19 vaccine administration.FindingsWe report data from 214 adults with myeloma (n=204) or smouldering myeloma (n=10) who provided blood samples at least 3 weeks after second vaccine dose. Positive Anti-Spike antibody levels (> 50 IU/ml) were detected in 189/203 (92.7%), positive IGRA responses were seen in 97/158 (61.4%) myeloma patients. Only 10/158 (6.3%) patients were identified to have both a negative IGRA and negative Anti-Spike protein antibody response. 95/158 (60.1%) patients produced positive results for both anti-Spike protein serology and IGRA. After adjusting for disease severity and myeloma therapy, poor humoral immune response was predicted by male gender. Predictors of poor IGRA included anti-CD38/ anti-BCMA therapy and Pfizer-BioNTech (PB) vaccination.InterpretationSignificant majority of myeloma patients elicit Anti-Spike protein antibody responses to COVID-19 vaccine with 60% of myeloma patients showing both humoral and T cell response. Predictors of a poor immune response included male gender, myeloma therapy regimen and administration of Pfizer-BioNTech vaccination. Further work is required to understand the clinical significance of divergent cellular response to vaccination.FundingFunding for this study has been received from Blood Cancer Vaccine Consortium and Janssen UK. RUDY platform has been funded by NIHR.
Published: 2022

36. Adherence to ESPEN guidelines and associations with postoperative outcomes in upper gastrointestinal cancer resection: results from the multi-centre NOURISH point prevalence study

Author: Emma McNamara, Lindy Parfrey, Kieu Huynh, Carmel Zoanetti, Kai Chyi Lee, Stella Mexias, Roy Hoevenaars, Eliza Simpson, Tayla Robertson, Georgina Lockwood, Siobhan Wallin, Emma Hamdorf, Elizabeth Isenring, Justin M. C. Yeung, Natalie Brooks, Rachel Pons, Claire Nixon, Claire Douglas, Catrina Gray, Karina Haaksma, Nadia Hames, Gayathri Jegendran, Janan Arslan, Sheena Singh, Kate Fox, Kiah Witney Cochrane, Georgia Moore, Naomi Page, Emma Putrus, Brook Maguire, Eleanor Quinn, Annika Dorey, Nicole Kiss, Lauren Nevin, Kate Furness, Caitlin Davis, Simone McCoy, Tayla Storr, Vanessa M. Carter, Teresa Brown, Suzie Daniells, Nadia Hendricks, Emma Whelan, Anna Cardamis, Jacqueline McNamara, Christine Choong, Jemma Corrigan, Aurora Ottaway, Irene Deftereos, Daniel Platt, and Brydie Cleeve
Subjects: Parenteral Nutrition, medicine.medical_specialty, Nutrition and Dietetics, Nutritional Support, business.industry, Endocrinology, Diabetes and Metabolism, Australia, Prevalence, Cancer, Guideline, medicine.disease, Enteral administration, Resection, Exact test, Malnutrition, Internal medicine, Humans, Medicine, Medical prescription, business, Gastrointestinal Neoplasms
Abstract: Postoperative nutrition support is an essential component of management in upper gastrointestinal (UGI) cancer resection, however there is limited knowledge of current clinical practice. This study aimed to describe the postoperative nutrition support received by patients undergoing UGI cancer resections, assess adherence with ESPEN surgical guideline recommendations, and to investigate differences between oesophageal, gastric and pancreatic surgeries. The secondary aim was to explore the association of adherence with ESPEN guidelines and provision of nutrition support, with surgical complications and length of stay (LOS).The NOURISH point prevalence study was conducted between September 2019-June 2020 across 27 Australian tertiary centres. Malnutrition was diagnosed using subjective global assessment. Data on postoperative diet codes, prescription of nutrition support (oral (ONS), enteral (EN), parenteral (PN)) and nutritional adequacy were collected by dietitians for the first 10 days of admission. Fisher's exact test was used to determine differences in nutritional management and adherence to ESPEN guidelines between surgery types. Multivariate regression analysed associations with surgical outcomes.Two-hundred participants were included (42% pancreatic, 33% oesophageal, 25% gastric surgery). Overall, only 34.9% (n = 53) met the guideline recommendations that were applicable to them. Early oral intake of fluids or solids (within 24 h post surgery) was initiated for 23.5% (n = 47), whilst ONS/EN/PN was initiated for 49.5% (n = 99). Only 25% of pancreatic surgeries had nutrition support initiated on the first postoperative day compared to 86.4% of oesophageal and 42.0% of gastric surgeries (p 0.001). In those who were 'nil by mouth', EN/PN were commenced within 24 h for 51.0% (n = 78), with 18.5% and 45.2% for pancreatic and gastric surgeries compared to 86.0% in oesophageal surgeries (p 0.001). In malnourished patients, 35.7% (n = 30) commenced EN within 24 h, with 11.1% and 31.8% for pancreatic and gastric compared to 73.1% in oesophageal surgeries (p 0.001). For patients meeting60% energy/protein requirements for ≥7 days, only 14.8% (n = 9) received EN/PN, with 2.5% and 16.7% of pancreatic and gastric compared to 75.0% of oesophageal surgeries (p 0.001). The number of days spent 'nil by mouth' or 'clear fluids' without EN/PN, as well as number of days with60% estimated requirements met were independently associated with increased LOS and complications.Overall, there was poor adherence to the majority of assessed ESPEN guidelines, and care for patients undergoing pancreatic and gastric surgeries was less compliant than oesophagectomy. Poor nutritional adequacy was associated with increased LOS and complications. There is a clear need for knowledge translation and implementation studies to increase adherence to evidence-based recommendations in the Australian setting supported by an understanding of barriers and enablers to optimal postoperative nutrition management.
Published: 2022

37. Clinician Perspectives Guiding Approach to Comprehensiveness of Palliative Care Assessment

Author: Laura C. Hanson, Arif H. Kamal, Nathan A. Gray, Christine S. Ritchie, Jean S. Kutner, Janet Bull, and Kimberly S. Johnson
Subjects: medicine.medical_specialty, Palliative care, Tailored approach, media_common.quotation_subject, Surveys and Questionnaires, Humans, Medicine, Nurse Practitioners, Spirituality, Quality (business), Referral and Consultation, General Nursing, Quality of Health Care, media_common, business.industry, Palliative Care, Health services research, Workload, General Medicine, Guideline, United States, Anesthesiology and Pain Medicine, Scale (social sciences), Family medicine, Brief Reports, business, Psychosocial
Abstract: BACKGROUND: National Consensus Project for quality palliative care guidelines emphasizes the importance of a comprehensive assessment of all care domains, including physical, psychosocial, and spiritual aspects of care, for seriously ill patients. However, less is known about how real-world practice compares with this guideline. OBJECTIVE: To describe clinicians' assessment practices and factors influencing their approach. DESIGN: This is a two-part web-based survey of palliative care clinicians from five academic groups in the United States. RESULTS: Nineteen out of 25 invited clinicians (physicians, nurse practitioners, and physician assistants) completed the survey. A majority (62%) reported that, although some elements of assessment were mandatory, their usual practice was to tailor the focus of the consultation. Time limitations and workload received the highest mean scores as reasons for tailored assessment (6.1 on a 0–9 importance scale), followed by beliefs that comprehensive assessment is unnecessary (4.8) and absence of the full interdisciplinary team (4.4). All participants cited symptom acuity, and 91% cited reason for consult as factors influencing a tailored approach. Among domains “always” assessed, physical symptoms were reported most commonly (81%) and spiritual and cultural factors least commonly (24% and 19%, respectively). Although a majority of clinicians reported usually tailoring their consultations, mean importance scores for almost all assessment elements were high (range 3.9–8.8, mean 7.1); however, there was some variation based on reason for consult. Spiritual elements received lower importance scores relative to other elements (5.0 vs. 7.4 mean score for all others). CONCLUSION: Although clinicians placed high importance on most elements included in comprehensive palliative care, in practice they often tailored their consultations, and the perceived relative importance of domains shifted depending upon the type of consultation.
Published: 2022

38. Death and Dying in Hospitalized Pediatric Patients: A Prospective Multicenter, Multinational Study

Author: Kristen Middaugh, Jessica Nicoll, Chris Parshuram, Ari R. Joffe, Helena Frndova, Karen Dryden-Palmer, Vinay M. Nadkarni, Catherine Farrell, Leah Szadkowski, David Wensley, Jacques Lacroix, Elizabeth A. Hunt, James S. Hutchison, George Tomlinson, Martin Gray, and Ronald Gottesman
Subjects: medicine.medical_specialty, Palliative care, Intensive Care Units, Pediatric, law.invention, Randomized controlled trial, law, Terminal care, medicine, Humans, Prospective Studies, EPOCH (chemotherapy), Child, Generalized estimating equation, General Nursing, Resuscitation Orders, Retrospective Studies, Pediatric intensive care unit, Terminal Care, business.industry, Palliative Care, General Medicine, Intensive care unit, Confidence interval, Anesthesiology and Pain Medicine, Emergency medicine, business
Abstract: Background: For hospitalized children admitted outside of a critical care unit, the location, mode of death, "do-not-resuscitate" order (DNR) use, and involvement of palliative care teams have not been described across high-income countries. Objective: To describe location of death, patient and terminal care plan characteristics of pediatric inpatient deaths inside and outside the pediatric intensive care unit (PICU). Design: Secondary analysis of inpatient deaths in the Evaluating Processes of Care and Outcomes of Children in Hospital (EPOCH) randomized controlled trial. Setting/Subjects: Twenty-one centers from Canada, Belgium, the United Kingdom, Ireland, Italy, the Netherlands, and New Zealand. Measurement: Descriptive statistics were used to compare patient and terminal care plan characteristics. A multivariable generalized estimating equation examined if palliative care consult during hospital admission was associated with location of death. Results: A total of 365 of 144,539 patients enrolled in EPOCH died; 219 (60%) died in PICU and 143 (40%) died on another inpatient unit. Compared with other inpatient wards, patients who died in PICU were less likely to be expected to die, have a DNR or palliative care consult. Hospital palliative care consultation was more common in older children and independently associated with a lower adjusted odds (95% confidence interval) of dying in PICU [0.59 (0.52-0.68)]. Conclusion: Most pediatric inpatient deaths occur in PICU where patients were less likely to have a DNR or palliative care consult. Palliative care consultation could be better integrated into end-of-life care for younger children and those dying in PICU.
Published: 2022

39. Survey study of trends in adult nephrology advanced training in Australia and New Zealand

Author: Andrea K. Viecelli, Nicholas A Gray, Scott B. Campbell, and Julian Yaxley
Subjects: Adult, Response rate (survey), medicine.medical_specialty, business.industry, Public health, education, Australia, Specialty, Subspecialty, Likert scale, Test (assessment), Nephrology, Private practice, Surveys and Questionnaires, Family medicine, Internal Medicine, medicine, Humans, Fellowships and Scholarships, business, Competence (human resources), New Zealand
Abstract: BACKGROUND: There has been considerable growth in nephrology advanced trainee numbers in Australia and New Zealand, with uncertain effects on clinical experience, competence and employment outcomes. AIM: To review the perceived adequacy and temporal trends of advanced training in nephrology in Australia and New Zealand by evaluating training experiences, personal views on important aspects of training and nephrology, career paths and early employment outcomes. METHODS: An online survey was distributed to members of the Australian and New Zealand Society of Nephrology via email in December 2020. Responses were sought from current trainees and from nephrologists qualifying since 2014. Likert scale proportions were calculated and group comparisons made using the Chi-square test. RESULTS: A total of 88 participants returned the survey yielding a response rate of 32%, with a representative sample of trainees and consultants from across Australia and New Zealand. Training was reported as adequate in most aspects of clinical nephrology, although 88% of respondents felt poorly prepared for entering private practice and 61% reported inadequate training in kidney histopathology. Exposure to clinical procedures was variable, with adequate training in percutaneous kidney biopsy but mostly inadequate training in dialysis access insertion. Sixty-nine percent of nephrologists completed their advanced training entirely in large urban centres and 85% worked in an urban area after training. Only 23% of consultants were engaged in full-time clinical employment in their first year post-training and 78% were undertaking at least one of dual specialty training or a higher degree by research. Demand for subspecialty fellowships was high. CONCLUSION: Trainees and nephrologists in Australia and New Zealand are currently satisfied with their training in most aspects of nephrology, however some clinical experiences are perceived as inadequate and early career paths after advanced training are increasingly diverse. This article is protected by copyright. All rights reserved.
Published: 2022

40. Whole Genome Sequence Analysis of the Plasma Proteome in Black Adults Provides Novel Insights Into Cardiovascular Disease

Author: Daniel H. Katz, Usman A. Tahir, Alexander G. Bick, Akhil Pampana, Debby Ngo, Mark D. Benson, Zhi Yu, Jeremy M. Robbins, Zsu-Zsu Chen, Daniel E. Cruz, Shuliang Deng, Laurie Farrell, Sumita Sinha, Alec A. Schmaier, Dongxiao Shen, Yan Gao, Michael E. Hall, Adolfo Correa, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Xiuqing Guo, Jie Yao, Yii-Der Ida Chen, Ani W. Manichaikul, Deepti Jain, Claude Bouchard, Mark A. Sarzynski, Stephen S. Rich, Jerome I. Rotter, Thomas J. Wang, James G. Wilson, Pradeep Natarajan, Robert E. Gerszten, Namiko Abe, Gonçalo Abecasis, Francois Aguet, Christine Albert, Laura Almasy, Alvaro Alonso, Seth Ament, Peter Anderson, Pramod Anugu, Deborah Applebaum-Bowden, Kristin Ardlie, Dan Arking, Donna K. Arnett, Allison Ashley-Koch, Stella Aslibekyan, Tim Assimes, Paul Auer, Dimitrios Avramopoulos, Najib Ayas, Adithya Balasubramanian, John Barnard, Kathleen Barnes, R. Graham Barr, Emily Barron-Casella, Lucas Barwick, Terri Beaty, Gerald Beck, Diane Becker, Lewis Becker, Rebecca Beer, Amber Beitelshees, Emelia Benjamin, Takis Benos, Marcos Bezerra, Larry Bielak, Joshua Bis, Thomas Blackwell, John Blangero, Eric Boerwinkle, Donald W. Bowden, Russell Bowler, Jennifer Brody, Ulrich Broeckel, Jai Broome, Deborah Brown, Karen Bunting, Esteban Burchard, Carlos Bustamante, Erin Buth, Brian Cade, Jonathan Cardwell, Vincent Carey, Julie Carrier, April Carson, Cara Carty, Richard Casaburi, Juan P. Casas Romero, James Casella, Peter Castaldi, Mark Chaffin, Christy Chang, Yi-Cheng Chang, Daniel Chasman, Sameer Chavan, Bo-Juen Chen, Wei-Min Chen, Michael Cho, Seung Hoan Choi, Lee-Ming Chuang, Mina Chung, Ren-Hua Chung, Clary Clish, Suzy Comhair, Matthew Conomos, Elaine Cornell, Carolyn Crandall, James Crapo, L. Adrienne Cupples, Joanne Curran, Jeffrey Curtis, Brian Custer, Coleen Damcott, Dawood Darbar, Sean David, Colleen Davis, Michelle Daya, Mariza de Andrade, Lisa de las Fuentes, Paul de Vries, Michael DeBaun, Ranjan Deka, Dawn DeMeo, Scott Devine, Huyen Dinh, Harsha Doddapaneni, Qing Duan, Shannon Dugan-Perez, Ravi Duggirala, Jon Peter Durda, Susan K. Dutcher, Charles Eaton, Lynette Ekunwe, Adel El Boueiz, Patrick Ellinor, Leslie Emery, Serpil Erzurum, Charles Farber, Jesse Farek, Tasha Fingerlin, Matthew Flickinger, Myriam Fornage, Nora Franceschini, Chris Frazar, Mao Fu, Stephanie M. Fullerton, Lucinda Fulton, Stacey Gabriel, Weiniu Gan, Shanshan Gao, Margery Gass, Heather Geiger, Bruce Gelb, Mark Geraci, Soren Germer, Robert Gerszten, Auyon Ghosh, Richard Gibbs, Chris Gignoux, Mark Gladwin, David Glahn, Stephanie Gogarten, Da-Wei Gong, Harald Goring, Sharon Graw, Kathryn J. Gray, Daniel Grine, Colin Gross, C. Charles Gu, Yue Guan, Namrata Gupta, David M. Haas, Jeff Haessler, Michael Hall, Yi Han, Patrick Hanly, Daniel Harris, Nicola L. Hawley, Jiang He, Ben Heavner, Susan Heckbert, Ryan Hernandez, David Herrington, Craig Hersh, Bertha Hidalgo, James Hixson, Brian Hobbs, John Hokanson, Elliott Hong, Karin Hoth, Chao (Agnes) Hsiung, Jianhong Hu, Yi-Jen Hung, Haley Huston, Chii Min Hwu, Marguerite Ryan Irvin, Rebecca Jackson, Cashell Jaquish, Jill Johnsen, Andrew Johnson, Craig Johnson, Rich Johnston, Kimberly Jones, Hyun Min Kang, Robert Kaplan, Sharon Kardia, Shannon Kelly, Eimear Kenny, Michael Kessler, Alyna Khan, Ziad Khan, Wonji Kim, John Kimoff, Greg Kinney, Barbara Konkle, Charles Kooperberg, Holly Kramer, Christoph Lange, Ethan Lange, Leslie Lange, Cathy Laurie, Cecelia Laurie, Meryl LeBoff, Jiwon Lee, Sandra Lee, Wen-Jane Lee, Jonathon LeFaive, David Levine, Dan Levy, Joshua Lewis, Xiaohui Li, Yun Li, Henry Lin, Honghuang Lin, Xihong Lin, Simin Liu, Yu Liu, Ruth J.F. Loos, Steven Lubitz, Kathryn Lunetta, James Luo, Ulysses Magalang, Michael Mahaney, Barry Make, Ani Manichaikul, Alisa Manning, JoAnn Manson, Lisa Martin, Melissa Marton, Susan Mathai, Rasika Mathias, Susanne May, Patrick McArdle, Merry-Lynn McDonald, Sean McFarland, Stephen McGarvey, Daniel McGoldrick, Caitlin McHugh, Becky McNeil, Hao Mei, James Meigs, Vipin Menon, Luisa Mestroni, Ginger Metcalf, Deborah A. Meyers, Emmanuel Mignot, Julie Mikulla, Nancy Min, Mollie Minear, Ryan L. Minster, Braxton D. Mitchell, Matt Moll, Zeineen Momin, May E. Montasser, Courtney Montgomery, Donna Muzny, Josyf C. Mychaleckyj, Girish Nadkarni, Rakhi Naik, Take Naseri, Sergei Nekhai, Sarah C. Nelson, Bonnie Neltner, Caitlin Nessner, Deborah Nickerson, Osuji Nkechinyere, Kari North, Jeff O’Connell, Tim O’Connor, Heather Ochs-Balcom, Geoffrey Okwuonu, Allan Pack, David T. Paik, Nicholette Palmer, James Pankow, George Papanicolaou, Cora Parker, Gina Peloso, Juan Manuel Peralta, Marco Perez, James Perry, Ulrike Peters, Patricia Peyser, Lawrence S. Phillips, Jacob Pleiness, Toni Pollin, Wendy Post, Julia Powers Becker, Meher Preethi Boorgula, Michael Preuss, Bruce Psaty, Pankaj Qasba, Dandi Qiao, Zhaohui Qin, Nicholas Rafaels, Laura Raffield, Mahitha Rajendran, Vasan S. Ramachandran, D.C. Rao, Laura Rasmussen-Torvik, Aakrosh Ratan, Susan Redline, Robert Reed, Catherine Reeves, Elizabeth Regan, Alex Reiner, Muagututi’a Sefuiva Reupena, Ken Rice, Stephen Rich, Rebecca Robillard, Nicolas Robine, Dan Roden, Carolina Roselli, Jerome Rotter, Ingo Ruczinski, Alexi Runnels, Pamela Russell, Sarah Ruuska, Kathleen Ryan, Ester Cerdeira Sabino, Danish Saleheen, Shabnam Salimi, Sejal Salvi, Steven Salzberg, Kevin Sandow, Vijay G. Sankaran, Jireh Santibanez, Karen Schwander, David Schwartz, Frank Sciurba, Christine Seidman, Jonathan Seidman, Frédéric Sériès, Vivien Sheehan, Stephanie L. Sherman, Amol Shetty, Aniket Shetty, Wayne Hui-Heng Sheu, M. Benjamin Shoemaker, Brian Silver, Edwin Silverman, Robert Skomro, Albert Vernon Smith, Jennifer Smith, Josh Smith, Nicholas Smith, Tanja Smith, Sylvia Smoller, Beverly Snively, Michael Snyder, Tamar Sofer, Nona Sotoodehnia, Adrienne M. Stilp, Garrett Storm, Elizabeth Streeten, Jessica Lasky Su, Yun Ju Sung, Jody Sylvia, Adam Szpiro, Daniel Taliun, Hua Tang, Margaret Taub, Matthew Taylor, Simeon Taylor, Marilyn Telen, Timothy A. Thornton, Machiko Threlkeld, Lesley Tinker, David Tirschwell, Sarah Tishkoff, Hemant Tiwari, Catherine Tong, Russell Tracy, Michael Tsai, Dhananjay Vaidya, David Van Den Berg, Peter VandeHaar, Scott Vrieze, Tarik Walker, Robert Wallace, Avram Walts, Fei Fei Wang, Heming Wang, Jiongming Wang, Karol Watson, Jennifer Watt, Daniel E. Weeks, Joshua Weinstock, Bruce Weir, Scott T. Weiss, Lu-Chen Weng, Jennifer Wessel, Cristen Willer, Kayleen Williams, L. Keoki Williams, Carla Wilson, James Wilson, Lara Winterkorn, Quenna Wong, Joseph Wu, Huichun Xu, Lisa Yanek, Ivana Yang, Ketian Yu, Seyedeh Maryam Zekavat, Yingze Zhang, Snow Xueyan Zhao, Wei Zhao, Xiaofeng Zhu, Michael Zody, and Sebastian Zoellner
Subjects: Adult, Male, Proteomics, Aging, Whole genome sequence analysis, Proteome, Clinical Sciences, Black People, Disease, Computational biology, race and ethnicity, Cardiorespiratory Medicine and Haematology, Cardiovascular, Article, proteomics, cardiovascular disease, Physiology (medical), Genetics, 2.1 Biological and endogenous factors, Humans, Medicine, Aetiology, Lung, Heart Disease - Coronary Heart Disease, and Blood Institute TOPMed (Trans-Omics for Precision Medicine) Consortium†, business.industry, Prevention, Human Genome, National Heart, Genomics, Blood proteins, Genetic architecture, Heart Disease, Good Health and Well Being, Cardiovascular System & Hematology, Cardiovascular Diseases, Public Health and Health Services, Female, Cardiology and Cardiovascular Medicine, business, Biotechnology, Genome-Wide Association Study
Abstract: Background: Plasma proteins are critical mediators of cardiovascular processes and are the targets of many drugs. Previous efforts to characterize the genetic architecture of the plasma proteome have been limited by a focus on individuals of European descent and leveraged genotyping arrays and imputation. Here we describe whole genome sequence analysis of the plasma proteome in individuals with greater African ancestry, increasing our power to identify novel genetic determinants. Methods: Proteomic profiling of 1301 proteins was performed in 1852 Black adults from the Jackson Heart Study using aptamer-based proteomics (SomaScan). Whole genome sequencing association analysis was ascertained for all variants with minor allele count ≥5. Results were validated using an alternative, antibody-based, proteomic platform (Olink) as well as replicated in the Multi-Ethnic Study of Atherosclerosis and the HERITAGE Family Study (Health, Risk Factors, Exercise Training and Genetics). Results: We identify 569 genetic associations between 479 proteins and 438 unique genetic regions at a Bonferroni-adjusted significance level of 3.8×10 -11 . These associations include 114 novel locus-protein relationships and an additional 217 novel sentinel variant-protein relationships. Novel cardiovascular findings include new protein associations at the APOE gene locus including ZAP70 (sentinel single nucleotide polymorphism [SNP] rs7412-T, β=0.61±0.05, P =3.27×10 -30 ) and MMP-3 (β=-0.60±0.05, P =1.67×10 -32 ), as well as a completely novel pleiotropic locus at the HPX gene, associated with 9 proteins. Further, the associations suggest new mechanisms of genetically mediated cardiovascular disease linked to African ancestry; we identify a novel association between variants linked to APOL1-associated chronic kidney and heart disease and the protein CKAP2 (rs73885319-G, β=0.34±0.04, P =1.34×10 -17 ) as well as an association between ATTR amyloidosis and RBP4 levels in community-dwelling individuals without heart failure. Conclusions: Taken together, these results provide evidence for the functional importance of variants in non-European populations, and suggest new biological mechanisms for ancestry-specific determinants of lipids, coagulation, and myocardial function.
Published: 2022

41. Changes in inferior vena cava area represent a more sensitive metric than changes in filling pressures during experimental manipulation of intravascular volume and tone

Author: Marat Fudim, Javed Butler, Kenneth McDonald, Juan Betuel Ivey-Miranda, Robert Gaul, Devin Mahoney, Stephen Sheridan, Barry A. Borlaug, Jeffrey M. Testani, Alastair P Gray, Kevin Damman, Daniel Burkhoff, Christopher Maulion, Alexandre Mebazaa, Jennifer L. Asher, Veena S. Rao, Martin R. Cowie, Friedrich Wetterling, Zachary L. Cox, and Cardiovascular Centre (CVC)
Subjects: Cardiac function curve, Cardiac Catheterization, medicine.medical_specialty, Central Venous Pressure, Heart Diseases, Vena Cava, Inferior, Vasodilation, Volume loading, Inferior vena cava, medicine.artery, Internal medicine, medicine, Intravascular volume status, Animals, Humans, Heart Failure, Sheep, business.industry, medicine.disease, Additional research, medicine.vein, Heart failure, Pulmonary artery, cardiovascular system, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract: AIMS: Remote monitoring of pulmonary artery pressure has reduced heart failure (HF) hospitalizations in chronic HF as elevation of pulmonary artery pressure provides information that can guide treatment. The venous system is characterized by high capacitance, thus substantial increases in intravascular volume can occur before filling pressures increase. The inferior vena cava (IVC) is a highly compliant venous conduit and thus a candidate for early detection of change in intravascular volume. We aimed to compare IVC cross-sectional area using a novel sensor with cardiac filling pressures during experimental manipulation of volume status, vascular tone, and cardiac function.METHODS AND RESULTS: Experiments were conducted in sheep to manipulate volume status (colloid infusion), vascular tone (nitroglycerin infusion) and cardiac function (rapid cardiac pacing). A wireless implantable IVC sensor was validated ex-vivo and in-vivo, and then used to measure the cross-sectional area of the IVC. Right- and left-sided cardiac filling pressures were obtained via right heart catheterization. The IVC sensor provided highly accurate and precise measurements of cross-sectional area in ex-vivo and in-vivo validation. IVC area changes were more sensitive than the corresponding changes in cardiac filling pressures during colloid infusion (p CONCLUSIONS: Inferior vena cava area can be remotely and accurately measured in real time with a wireless implantable sensor. Changes in IVC area are more sensitive than corresponding changes in filling pressures following experimental volume loading and fluid redistribution. Additional research is warranted to understand if remote monitoring of the IVC may have advantages over pressure-based monitors in HF.
Published: 2022

42. The impact of common factors on coaching outcomes

Author: Robert van der Veen, Erik de Haan, Joanna Molyn, David Gray, Management and Organisation, and VU SBE Executive Education
Subjects: Organizational Behavior and Human Resource Management, Social Psychology, coaching outcomes, business.industry, education, Applied psychology, social support, Coaching, Social support, working alliance, expectancies and hope, Developmental and Educational Psychology, Common factors, business, Psychology, human activities
Abstract: Previous studies examining coaching outcomes generally rely on cross-sectional data which limits our understanding of the enduring and long-term effects of coaching. To address this issue, this study, based on longitudinal data, explores several popular variables associated with coaching outcomes. The study is underpinned by Lambert’s [(1992). Lambert, M. J. (1992). Psychotherapy outcome research: Implications for integrative and eclectic therapists. In J. C. Norcross, & M. R. Goldfried (Eds.), Handbook of psychotherapy integration (pp. 94–129). Basic Books] four-factor model of common factors and recognises them as variables which are customary to all coaching approaches contributing to coaching outcomes. The study considers stress, wellbeing, resilience, goal attainment and coaching effectiveness as coaching outcomes. Working alliance mediates the impact of self-efficacy, outcome expectations; and perceived social support which are regarded as the predictors of the coaching outcomes. The results indicate that social support predicts working alliance, and working alliance in turn predicts wellbeing and coaching effectiveness over time. The findings suggest that it is vital for coaches to monitor changes in the coachees’ social networks and their working alliance since these have a significant bearing on the effectiveness of the sessions and the coachees’ wellbeing.
Published: 2022

43. Employment search, initial employment experience, and career preferences of recent pediatric surgical fellowship graduates: An APSA survey, part of the right child/right surgeon initiative

Author: Samuel M. Alaish, Michael R. Phillips, Shawn D. Safford, Abigail E. Martin, Claudia N. Emami, Stephen P. Dunn, Brian W. Gray, Christian S. McEvoy, Patrick J. Healey, Anthony L DeRoss, Kimberly Lumpkins, Stefan Scholz, and Faisal G. Qureshi
Subjects: Employment, Surgeons, Medical education, Career Choice, business.industry, General Medicine, Specialties, Surgical, Surveys and Questionnaires, Pediatrics, Perinatology and Child Health, Humans, Medicine, Surgery, Fellowships and Scholarships, business
Abstract: APSA's Right Child/Right Surgeon Initiative addresses issues concerning patient access to appropriate pediatric surgical care and workforce distribution. The APSA Workforce Committee sought to understand the experiences and motivations of recent graduates of Pediatric Surgery Training Programs entering the workforce.Using APSA membership databases, we identified members who completed fellowship training from 2010 to 2019. An online survey was created using Survey Monkey, and invitations to participate were sent via email.144 of 447 invited participants responded (32% response rate). 91% of respondents participated in dedicated research prior to fellowship, but only 64% perform research during their employment. 23% completed an additional clinical fellowship, but only 54% currently practice within the second field. When asked to identify the top three factors used to choose a position, the most common responses were "location or geography" (71%), "available mentorship" (53%), and "compensation and benefits" (37%). Describing their first position, 77% reported working in an academic institution, 78% reported working in a metropolitan/urban area, and 55% reported working in a free-standing children's hospital. 94% participate in General Surgery resident education, and 49% are faculty within a Pediatric Surgery fellowship. Overall, 92% of respondents were able to find the type of employment position that they had wanted.In our survey the overwhelming majority of young pediatric surgeons found the type of job they desired. Most report beginning their practice in more populated, urban areas within academic institutions. Geographic location and work environment played heavily into their employment decisions. These preferences could contribute to continued disparity in access to pediatric surgeons between urban and rural America and to dilution of experience for urban surgeons. Possible solutions include alternative incentive programs for employment in less populated areas or new training models for general surgeons in rural areas to train in fundamentals of Pediatric Surgery.
Published: 2022

44. The Relationship Between Obesity and Amputation-free Survival in Patients Undergoing Lower-limb Revascularisation for Chronic Limb-threatening Ischaemia: A Retrospective Cohort Study

Author: Svetlana Dubkova, Bhavisha Patel, Andrew T.O. Nickinson, Cezar Sabbagh, Rob D. Sayers, Laura J. Gray, Sarah Cullen, and Robert S.M. Davies
Subjects: Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Context (language use), Overweight, Risk Assessment, Amputation, Surgical, Peripheral Arterial Disease, Ischemia, Risk Factors, Internal medicine, medicine, Humans, Obesity, Survival analysis, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Retrospective cohort study, General Medicine, Middle Aged, Protective Factors, Limb Salvage, Progression-Free Survival, Lower Extremity, Amputation, Female, Surgery, medicine.symptom, Underweight, Cardiology and Cardiovascular Medicine, business, Vascular Surgical Procedures, Body mass index, Obesity paradox
Abstract: Background The obesity paradox is a well-documented phenomenon in cardiovascular disease, however it remains poorly understood. We aimed to investigate the relationship between body mass (as measured by body mass index [BMI]) and 1-year amputation-free survival (AFS) for patients undergoing lower limb revascularisation for chronic limb-threatening ischaemia (CLTI). Methods A retrospective analysis was undertaken of all consecutive patients undergoing lower limb revascularisation for CLTI at the Leicester Vascular Institute between February 2018–19. Baseline demographics and outcomes were collected using electronic records. BMI was stratified using the World Health Organization criteria. One-year AFS (composite of major amputation/death) was the primary outcome. Kaplan-Meier survival analysis and adjusted Cox's proportional hazard models were used to compare groups to patients of normal mass. Results One-hundred and ninety patients were included. Overall, no difference was identified in 1-year AFS across all groups (pooled P = 0.335). Compared to patients with normal BMI (n = 66), obese patients (n = 43) had a significantly lower adjusted combined risk of amputation/death (aHR 0.39, 95% CI 0.16–0.92, P = 0.032), however no significant differences were observed for overweight (aHR 0.89, 95% CI 0.47–1.70, P = 0.741), morbidly obese (aHR 1.15, 95% CI 0.41–3.20, P = 0.797) and underweight individuals (aHR 1.86, 95% CI 0.56–6.20, P = 0.314). Conclusions In the context of CLTI, obesity is potentially associated with favourable amputation-free survival at 1 year, compared to normal body mass. The results of this study support the notion of an obesity paradox existing within CLTI and question whether current guidance on weight management requires a more patient-specific approach.
Published: 2022

45. Early Surgery for Spontaneous Pneumothorax Associated With Reduced Recurrence, Resource Utilization

Author: Cody Tragesser, Cameron L. Colgate, Matthew P. Landman, Brian W. Gray, and Niloufar Hafezi
Subjects: Adult, medicine.medical_specialty, Adolescent, Demographics, Single Center, Young Adult, Early surgery, Recurrence, Thoracoscopy, Humans, Medicine, Child, Retrospective Studies, First admission, medicine.diagnostic_test, Thoracic Surgery, Video-Assisted, business.industry, Pneumothorax, nutritional and metabolic diseases, Primary spontaneous pneumothorax, medicine.disease, Surgery, Hospitalization, Treatment Outcome, Child, Preschool, business, human activities, tissues, Resource utilization
Abstract: Primary spontaneous pneumothorax (PSP) occurs in adolescent patients and frequently recurs. Reliable predictors of recurrence may identify candidates for early VATS (video-assisted thoracoscopic surgery). We hypothesize that demographic and clinical factors are associated with recurrence, and that earlier surgery is associated with decreased recurrence and resource utilization.Patients between ages 5 and 21 treated for PSP at a single center from January 1, 2008 to June 30th, 2019 were identified. Presenting demographics, clinical management, and outcomes were analyzed, with focus on the first admission for PSP. "Early VATS" was defined as VATS during the first admission, and "late VATS" as VATS at any point after the first admission for a given side.Thirty-nine patients met inclusion criteria, with a total of 82 pneumothoraces. Following initial encounter, 48.7% had ipsilateral recurrence. Early VATS was associated with less recurrence (P = 0.002). No other predictive factors were associated with ipsilateral recurrence. Early VATS was associated with reduced overall recurrence (P0.001), admissions (P0.001), cumulative chest x-rays (P = 0.043), and cumulative hospital length of stay (P = 0.022) compared to late VATS.While predictors of recurrence are not apparent at initial admission, early VATS is associated with decreased recurrence and resource utilization.
Published: 2022

46. Overall Treatment Strategy for Patients With Metastatic NSCLC With Activating EGFR Mutations

Author: Christian Grohé, Nicola Caria, Tarun Puri, Hidetoshi Hayashi, Ernest Nadal, Jhanelle E. Gray, and Andrea Ardizzoni
Subjects: Pulmonary and Respiratory Medicine, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Antineoplastic Agents, Disease-Free Survival, Metastasis, Therapeutic approach, chemistry.chemical_compound, T790M, Clinical trials, Metàstasi, Carcinoma, Non-Small-Cell Lung, Internal medicine, medicine, Humans, Osimertinib, Epidermal growth factor receptor, Neoplasm Metastasis, Lung cancer, Randomized Controlled Trials as Topic, Chemotherapy, biology, business.industry, Genes, erbB-1, medicine.disease, respiratory tract diseases, Vascular endothelial growth factor, Drug Combinations, chemistry, Mutation, Càncer de pulmó, biology.protein, business, Tyrosine kinase, Assaigs clínics
Abstract: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) are standard of care in the first-line (1L) setting for patients with metastatic non-small cell lung cancer (mNSCLC) with activating EGFR mutations. EGFR-activating mutations are a predictive factor for response to EGFR-TKIs. Meta-analyses have shown that patients with exon 21_L858R mutations exhibit reduced sensitivity to EGFR-TKIs, resulting in inferior patient outcomes compared to those with exon 19 deletion mutations, with worse overall survival, progression-free survival, objective response, and disease control rates. Clinical activity observed with 1L therapy with first-generation (1G), second-generation (2G), and third-generation (3G) EGFR-TKIs is not permanent, and resistance inevitably develops in all cases, supporting the importance of overall treatment planning. The introduction of the 3G EGFR-TKI, osimertinib, provides an opportunity to overcome T790M-mediated resistance to 1G and 2G EGFR-TKIs. Additionally, with the use of osimertinib, fewer T790M mutations are being detected as T790M is not a reported resistance mechanism to 3G EGFR-TKIs. However, there are currently no approved targeted therapies after 3G EGFR-TKIs. In order to further improve patient outcomes, there is a need to explore additional options for the overall treatment strategy for patients, including 1L and beyond. Combination of vascular endothelial growth factor (VEGF) inhibitors and EGFR-TKIs or chemotherapy and EGFR-TKIs may be a potential therapeutic approach in the 1L setting. This review discusses current treatment options for mNSCLC with activating EGFR mutations based on tumor, patient, and treatment characteristics and how an overall treatment plan may be developed.
Published: 2022

47. Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Author: Obbina Abani, Ali Abbas, Fatima Abbas, Mustafa Abbas, Sadia Abbasi, Hakam Abbass, Alfie Abbott, Nabeel Abdallah, Ashraf Abdelaziz, Mohamed Abdelfattah, Bushra Abdelqader, David Abdo, Basir Abdul, Althaf Abdul Rasheed, Ajibode Abdulakeem, Rezan Abdul-Kadir, Amina Abdulle, Abdulfatahi Abdulmumeen, Rasheed Abdul-Raheem, Niyaz Abdulshukkoor, Kula Abdusamad, Yazeed Abed El Khaleq, Mai Abedalla, Abeer Ul Amna Abeer Ul Amna, Katrina Abernethy, Adebanke Aboaba, Hani Abo-Leyah, Ahmed Abou-Haggar, Mahmoud Abouibrahim, Miriam Abraham, Tizzy Abraham, Abraheem Abraheem, Judith Abrams, Hyacinth-John Abu, Ahmed Abu-Arafeh, Syed M Abubacker, Akata Abung, Yaa Aceampong, Amaka Achara, Devikumar Acharya, Sarah Acheampong, Janet Acheson, Andres Acosta, Catherine Acton, Jacqueline Adabie-Ankrah, Sara Adair, Fiona Adam, Matthew Adam, Huzaifa Adamali, Carol Adams, Charlotte Adams, Kate Adams, Lisa Adams, Richard Adams, Tim Adams, Kirsty Adcock, Jemaimah Addai, Ade Adebiyi, Ken Adegoke, Vicki Adell, Debo Ademokun, Sherna Adenwalla, Oluwasegun A Adesemoye, Emmanuel O Adewunmi, Joyce Adeyemi, Rina Adhikary, Gabrielle Adkins, Adnan Adnan, John Aeron-Thomas, Debbie Affleck, Dominic Affron, Carmel Afnan, Muhammad Afridi, Zainab A Aftab, Meenakshi Agarwal, Rachel Agbeko, Chris Agbo, Penny Agent, Sunil Aggarwal, Arameh Aghababaie, Shafana Ahamed Sadiq, Mohamed H Ahammed Nazeer, Humayun Ahmad, Mohammad Ahmad, Syed Ahmad, Asim Ahmed, Bilal Ahmed, Forizuddin Ahmed, Hamze Ahmed, Iram Ahmed, Irshad Ahmed, Khaled Ahmed, Liban Ahmed, Mahin Ahmed, Maria C Ahmed, Muhammad S Ahmed, Naseer Ahmed, Nausheen Ahmed, Osama Ahmed, Rajia A Ahmed, Rizwan Ahmed, Saif Ahmed, Sammiya Ahmed, Sara Ahmed, Sophia Ahmed, Syed Ahmed, Syed Haris Ahmed, Roa Ahmed Ali, Sana Ahmed, Sana Ahmer, Dhiraj Ail, Mark Ainsworth, Giulia Airoldi, Myriam Aissa, Lindianne Aitken, Bini Ajay, Francis Ajeneye, Abdulakeem Ajibode, Ayesha Ajmi, Tahir Akbar, Naim Akhtar, Nasim Akhtar, Nauman Akhtar, Suha Akili, Oludoyinsola Akindolie, Yinka Akinfenwa, Olugbenga Akinkugbe, Ibrahim Akinpelu, Olajide Akinwumiju, Olugbenro Aktinade, Ahmad Al Aaraj, Asma Al Balushi, Majd Al Dakhola, Aladdin Al Swaifi, Eslam Al-Abadi, Narendra Aladangady, Ayaz Alam, Sajid Alam, Abbas Al-Asadi, Karina Al-Asadi, Kyriaki Alatzoglou, Manaf Al-Bayati, Paul Albert, Lorraine Albon, Gemma Alcorn, Stephen Alcorn, Aggie Aldana, David Alderdice, Rayan Aldouri, Jonathan Aldridge, Nicolas Aldridge, Ana Alegria, Alison Alexander, John Alexander, Peter D G Alexander, Charlotte Alford, Julyan Al-Fori, Laith Alghazawi, Bahij Al-Hakim, Shams Al-Hity, Ali Ali, Asad Ali, Fawzia R Ali, Hoodo Ali, Jawad Ali, Mariam Ali, Mohammad Ali, Nayab Ali, Oudai Ali, Sabira Ali, Sakina Ali, Syed Ali, Abid Alina, Fine Aliyuda, Katrin Alizadeh, Maithem Al-Jibury, Saba Al-Juboori, Majid Al-Khalil, Moutaz Alkhusheh, Allameddine Allameddine, Fiona Allan, Rachel Allan, Alison Allanson, Robert Allcock, Beverley Allen, Eireann Allen, Jess Allen, Kerry Allen, Laura Allen, Louise Allen, Poppy Allen, Rebecca Allen, Sam Allen, Sharon Allen, Simon Allen, Kathryn Allison, Bethan Allman, Lynne Allsop, Hassan Al-Moasseb, Magda Al-Obaidi, Lina Alomari, Akram Al-Rabahi, Bahar Al-Ramadhani, Zayneb Al-Saadi, Inji Alshaer, Rustam Al-Shahi Salman, Warkaq Al-Shamkhani, Bashar Al-Sheklly, Sara Altaf, Mary Alvarez, Balaal Alyas, Maysaa Alzetani, Susan Amamou, Noor Amar, Sakkarai Ambalavanan, Sarah-Jayne Ambler, Robert Ambrogetti, Chris Ambrose, Amir Ameen, Kenneth Amenyah, Maria R Amezaga, Allison Amin, Amina Amin, Kanish Amin, Syed Amin, Tara Amin, Amjad Amjad, Neelma Amjad, Mariam Ammoun, Victoria Amosun, Khaled Amsha, Pugh Amy, Atul Anand, Rekha Anand, Samantha Anandappa, Julie Anderson, Kevin Anderson, Laura Anderson, Michelle Anderson, Nicola Anderson, Rachel Anderson, Rory Anderson, Wendy Anderson, Prematie Andreou, Angela Andrews, Antonette Andrews, Jill Andrews, Susan Andrews, Gregory Andrikopoulos, Kanayochukwu Aneke, Andrew Ang, Wan Wei Ang, Tammy Angel, Aramburo Angela, Paola Angelini, Lazarus Anguvaa, Oleg Anichtchik, Millicent Anim-Somuah, Krishnan Aniruddhan, Jessica Annett, Patrick J Anstey, Rebekah Anstey, Alpha Anthony, Aaron Anthony-Pillai, Philip Antill, Zhelyazkova Antonina, Varghese Anu, Muhammad Anwar, George Apostolides, Aristeidis Apostolopoulos, Sarah Appleby, Diane Appleyard, Maia Far Aquino, Bianca Araba, Samuel Aransiola, Mariana Araujo, Emily Arbon, Ann Archer, Denise Archer, Simon Archer, Christian Ardley, Ana-Maria Arias, Ryoki Arimoto, Charlotte Arkley, Charlotte Armah, Ilianna Armata, Adam Armitage, Ceri Armstrong, Maureen Armstrong, Sonia Armstrong, Sylvia Armstrong-Fisher, Philippa Armtrong, Heike Arndt, Clare Arnison-Newgass, David Arnold, Rachael Arnold, Sarah Arnott, Dhawal Arora, Kavan Arora, Pardeep Arora, Rishi Arora, Andrea Arroyo, Arslam Arter, Ayush Arya, Rita Arya, Denisa Asandei, Adeeba Asghar, Catherine Ashbrook-Raby, Glen Ashby, Helen Ashby, Jan Ashcroft, John Ashcroft, Samuel Ashcroft, Deborah Asher, 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Dinh, Tri Dinh, Alex Dipper, Laura Dirmantaite, Lisa Ditchfield, Sarah Diver, Lavanya Diwakar, Caroline Dixon, Giles Dixon, Stephen Dixon-Mould, Brice Djeugam, Petr Dlouhy, Laurence Dobbie, Marinela Dobranszky Oroian, Charlotte Dobson, Lee Dobson, Marie Docherty, David Dockrell, James Dodd, Jackie Dodds, Rebecca Dodds, Steve Dodds, Richi Dogra, Erin Doherty, Warren Doherty, Yumiko Doi, Iain Doig, Eleanor Doke, Daniel Dolan, Mark Dolman, Rozzie Dolman, Lisa Donald, Callum Donaldson, Christopher Donaldson, Denise Donaldson, Gillian Donaldson, Kate Donaldson, Joanne Donnachie, Christopher Donnelly, Eilish Donnelly, Ronan Donnelly, Aravindhan Donohoe, Gemma Donohoe, Bryan Donohue, Sinead Donton, Emma Dooks, Grainne Doran, Kane Dorey, Sharon Dorgan, Amanda Dornan, Moonira Dosani, Davinder Dosanjh, Paula Dospinescu, Katie Douglas, Jonathan Douse, Lucy Dowden, Michelle Dower, Kerry Dowling, Sud Dowling, Nicola Downer, Charlotte Downes, Rob Downes, Thomas Downes, Damian Downey, Philippa 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Eagles, Joanne Early, Melissa Earwaker, Nicholas Easom, Clare East, Kim East, Amy Easthope, Fraser Easton, Caroline Eaton, Caroline Eaton-Howell, Ruth Eatough, Adrian Ebbs, Oluwadamilola Ebigbola, Daniel Ebner, Martin Ebon, Sinan Eccles, Chloe Eddings, Michael Eddleston, Maureen Edgar, Katharine Edgerley, Nicholas Edmond, Julie Edmonds, Dave Edmondson, Mary Edmondson, Tracy Edmunds, Alexandra Edwards, Catherine Edwards, Joy Edwards, Kennedy Edwards, Mandy Edwards, Tomos Edwards, Jenny Eedle, Dawn Egginton, Loveth Ehiorobo, Sarah Eisen, Ugochukwu Ekeowa, Mohamed Ekoi, Ayomide Ekunola, Soha El Behery, Moulod El-Agnaf, Mohamed Elbeshy, Kate El-Bouzidi, Jennifer Elder, Mohammed El-Din, Diana Eleanor, Ibrahim Eletu, Eman Elfar, Mayy Magdy Elgamal, Amr Elgohary, Stellios Elia, Jennifer Elias, Tania Elias, Nadia Elkaram, Mohammed El-Karim, Andrew Victor Elkins, Julie Ellam, Nikki Ellard, Laura Nicola Ellerton, Lucy Elliot, Amy Elliott, Chris Elliott, Fiona Elliott, Kerry Elliott, Scott Elliott, Toby Elliott, Annie Ellis, Ann-Marie Ellis, Christine Ellis, Kay Ellis, Kaytie Ellis, Tak-Yan Ellis, Yvette Ellis, Megan Ellison, Rahma Elmahdi, Einas Elmahi, Hannah-May Elmasry, Mohammed Elmi, Najla Elndari, Omer Elneima, Mohamed Elokl, Ahmed Elradi, Mohamed Elsaadany, Sally El-Sayeh, Hana El-Sbahi, Tarek Elsefi, Karim El-Shakankery, Robert Elshaw, Hosni El-Taweel, Sarah Elyoussfi, Jonathan Emberey, Jonathan R Emberson, John Emberton, Julian Emmanuel, Ingrid Emmerson, Michael Emms, Florence Emond, Marieke Emonts, Nicu Enachi, Angila Engden, Katy English, Emma Entwistle, Hene Enyi, Marios Erotocritou, Helen Escreet, Peter Eskander, Hanif Esmail, Lise Estcourt, Amy Evans, Brynach Evans, Chris Evans, Daren Evans, Debra Evans, Gail Evans, Gareth Evans, Jennifer Evans, Lisa Evans, Lynn Evans, Margaret Evans, Michelle Evans, Mim Evans, Morgan Evans, Ranoromanana Evans, Ryan Evans, Teriann Evans, Terry John Evans, Tony Eve, Caroline Everden, Serenydd Everden, Hayley Evison, Lynsey Evison, Penny Eyton-Jones, Jacqueline Faccenda, Leila Fahel, Youstina Fahmay, Sara Fairbairn, Terry Fairbairn, Andy Fairclough, Louise Fairlie, Mark Fairweather, Anne Fajardo, Naomi Falcone, Euan Falconer, Jonathan Falconer, John Fallon, Andrea Fallow, David Faluyi, Victoria Fancois, Qayyum Farah, Novin Fard, Amr Farg, Margaret Farinto, Adam Farmer, Katie Farmer, Toni Farmery, Samantha Farnworth, Faiyaz Farook, Hadia Farooq, Sidrah Farooq, Fiona Farquhar, Karen Farrar, Aaron Farrell, Barbara Farrell, James Farthing, Syeda Farzana, Rahmatu Fasina, Azam Fatemi, Mina Fatemi, Nibah Fatimah, Maria Faulkner, Saul N Faust, Joe Fawke, Sinmidele Fawohunre, Abul Fazal, Kelly Feane, Simon Fearby, Alex Feben, Federico Fedel, Daria Fedorova, James Feely-Henderson, Christopher Fegan, Mae Felongco, Lynsey Felton, Tim Felton, Kate Fenlon, Andrea Fenn, Isabelle Fenner, Ciara Fenton, Melisa Fenton, Cameron Ferguson, Jenny Ferguson, Kathryn Ferguson, Katie Ferguson, Stephanie Ferguson, Susan Ferguson, Susie Ferguson, Victoria Ferguson, Denzil Fernandes, Candida Fernandez, Eduardo Fernandez, Maria Fernandez, Sonia Fernandez Lopez, Callum Jeevan Fernando, Ahmed Feroz, Pietro Ferranti, Thais Ferrari Gersogamo, Eleanor Ferrelly, Alexandra Ferrera, Emma Ferriman, Nicholas Fethers, Ben Field, Janet Field, Rebecca Field, Karen Fielder, Lindsey Fieldhouse, Andra Fielding, Julie Fielding, Len Fielding, Sarah Fielding, Asma Fikree, Sarah Ann Filson, Sarah Finbow, Debbie Finch, Joanne Finch, Laurie Finch, Joanne Finden, Natalie Fineman, Lauren Finlayson, Adam Finn, Joanne Finn, Clare Finney, Sofia Fiouni, Jo Fiquet, Dani Fisher, Emily Fisher, James Fisher, Neil Fisher, Meadow Fisher Crisp, Daniel Fishman, Krystofer Fishwick, Lorraine Fitzgerald, Chloe Fitzpatrick-Creamer, Jan Flaherty, Michael Flanagan, Charles Flanders, Cathy Flatters, Julie Fleming, Lucy Fleming, Paul Fleming, William Flesher, Alison Fletcher, Jonathan Fletcher, Lucy Fletcher, Simon Fletcher, Sophie Fletcher, Karen Flewitt, Christopher Flood, Ian Floodgate, Vincent Florence, Sharon Floyd, Kelly Flynn, Rachel Flynn, Sara Flynn, Claire Foden, Adama Fofana, Georgina Fogarty, Claire Foley, Paul Foley, Linda Folkes, Daniela Mock Font, Evodian Fonyonga, Aiwyne Foo, Jane Foo, Andrew Foot, Jayne Foot, Jane Forbes, Jamie Ford, Kathy Ford, Jennifer Foreman, Caroline Fornolles, Adam Forrest, Ellie Forsey, Miranda Forsey, Thomas Forshall, Elliot Forster, Julian Forton, Emily Foster, Joseph Foster, Rachel A Foster, Tracy Foster, Theodora Foukanelli, Angela Foulds, Ian Foulds, Folakemi Fowe, Emily Fowler, Robert Fowler, Stephen Fowler, Caroline Fox, Claire Fox, Daniel Fox, Heather Fox, Jonathan Fox, Lauren Fox, Natalie Fox, Olivia Fox, Simon Fox, Sarah-Jane Foxton, Yasin Fozdar, Rebecca Frake, Alex Francioni, Olesya Francis, Rebecca Francis, Sarah Francis, Theodora Francis-Bacon, Jason Frankcam, Helen Frankland, Gayle Franklin, Jessica Franklin, Darron Franks, Catherine Fraser, Laura Fraser, Sharon Frayling, Martyn Fredlund, Matthew Free, Carol Freeman, Elaine Freeman, Hannah Freeman, Nicola Freeman, Clare Freer, Ian Freestone, Eleanor French, Matthew Frise, Renate Fromson, Claire Froneman, Adam Frosh, John Frost, Victoria Frost, Oliver Froud, Rachel Frowd, Arun Fryatt, Jake Fryer, Janet Fu, Bridget Fuller, Liz Fuller, Neil Fuller, Tracy Fuller, Duncan Fullerton, Jenny Fullthorpe, Carrie Fung, Gayle Fung, Sarah Funnell, John Furness, Charlene Furtado, Andrew Fyfe, Nytianandan G, Elizabeth Gabbitas, Claire Gabriel, Diana Gabriel, Hadiza Gachi, Rose Gad, Joshua Gahir, Sarveen Gajebasia, Katarzyna Gajewska-Knapik, Zacharoula Galani, Christopher Gale, Hugo Gale, Rebecca Gale, Swetha Gali, Karen Galilee, Bernadette Gallagher, Jude Gallagher, Rosie Gallagher, William Gallagher, Joanne Galliford, Catherine Galloway, Chris Galloway, Emma Galloway, Jacqui Galloway, James Galloway, Laura Gamble, Liz Gamble, Brian Gammon, Jaikumar Ganapathi, Ramesh Ganapathy, Kaminiben Gandhi, Sarah Gandhi, Usha Ganesh, Abrar Gani, Emma-James Garden, Antoni D Gardener, Emma Gardiner, Jill Gardiner, Michael Gardiner, Phil Gardiner, Siobhan Gardiner, Caroline Gardiner-Hill, Jonathan Gardner, Mark Garfield, Atul Garg, Nathan Garlick, Justin Garner, Lucie Garner, Zoe Garner, Kimberley Garnett, Robert Garney, Rosaline Garr, Michael Garstka, Peter Gartan, Florence Garty, Rachel Gascoyne, Hyeriju Gashau, Noha Gasmalseed, Michaela Gaspar, Aoife Gatenby, Erin Gaughan, Alok Gaurav, Mariana Gavrila, Jane Gaylard, Emma Gaywood, Catherine Geddie, Alison Geddis, Ian Gedge, Sarah Gee, Minerva Gellamucho, Karzan Gelly, Leila Gelmon, Sandra Gelves-Zapata, Gemma Genato, Susan Gent, Natalie Geoghegan, Chloe George, Sam George, Tina George, Simon Georges, Domonique Georgiou, Peter Gerard, Leigh Gerdes, Louise Germain, Helen Gerrish, Abel Getachew, Louise Gethin, Hisham Ghanayem, Amardeep Ghattaoraya, Anca Gherman, Alison Ghosh, Justin Ghosh, Sudhamay Ghosh, Sarra Giannopoulou, Malick Gibani, Andrew Gibb, Ben Gibbison, Kerry Gibbons, Alex Gibson, Bethan Gibson, Kimberley Gibson, Kirsty Gibson, Sian Gibson, Cat Gilbert, Jeanette Gilbert, Joanne Gilbert, Kayleigh Gilbert, Sean Gilchrist, Benjamin Giles, Mandy Gill, Rose Gill, Lynne Gill, Paul Gillen, Annelies Gillesen, Katherine Gillespie, Matt Gillespie, Elizabeth Gillham, Andrew Gillian, Deborah Gilliland, Robert Gillott, Danielle Gilmour, Kate Gilmour, Theodora Giokanini-Royal, Anna Gipson, Joanna Girling, Rhian Gisby, Angelena Gkioni, Aikaterini Gkoritsa, Effrossyni Gkrania-Klotsas, Amy Gladwell, James Glanville, Jessica Glasgow, Susannah Glasgow, Jon Glass, Lynn Glass, Sharon Glaysher, Lisa Gledhill, Ana Glennon, John Glover, Kyle Glover, Jan Glover Bengtsson, Chevanthy Gnanalingam, Julie Goddard, Wendy Goddard, Emily Godden, Jo Godden, Gillian Godding, Emma Godson, Gerry Gogarty, Sukanya Gogoi, Aiky Goh, Rebeca Goiriz, Sriya Gokaraju, Philip Gold, Raphael Goldacre, Arthur Goldsmith, Portia Goldsmith, Darren Gomersall, Lucia Gomez, Raquel Gomez-Marcos, Ali Gondal, Celia Gonzalez, Jack Goodall, Bob Goodenough, Laura Goodfellow, James Goodlife, Camelia Goodwin, Elizabeth Goodwin, Jayne Goodwin, Paula Goodyear, Rajiv Gooentilleke, Sharif Goolam-Hossen, Michelle Goonasekara, Sheila Gooseman, Shameer Gopal, Peter Gordon, Sally Gordon, Hugh Gorick, Caitlin Gorman, Claire Gorman, Stuart Gormely, Diana Gorog, Jan Gorry, Michelle Gorst, Thomas Gorsuch, Jayshreebahen Gosai, Rebecca Gosling, Sally Gosling, Georgina Gosney, Vanessa Goss, Dzintars Gotham, Naomi Gott, Elizabeth Goudie, Amanda Gould, Angela Gould, Susan Gould, Lysander Gourbault, Anna Gouveia, Abha Govind, Sharon Gowans, Girish Gowda, Rohit Gowda, Pauline Gowdy, Hannah Gower, Thomas Gower, Pankaj Goyal, Sunil Goyal, Sushant Goyal, Beverley Graham, Clive Graham, Jane Graham, Jonathan Graham, Justin Graham, Libby Graham, Sharon Graham, Matthew Graham-Brown, Julia Grahamslaw, Gianluca Grana, Tracyanne Grandison, Louis Grandjean, Alison Grant, Ann Grant, David Grant, 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Griffiths, Yvonne Griffiths, Sofia Grigoriadou, Steph Grigsby, Paul Grist, Stephen Grist, Evelina Grobovaite, Clarissa Grondin, Rachel Groome, Liliana Grosu, Jenny Grounds, Margaret Grout, Helen Grover, Jayne Groves, Neil Grubb, Julie Grundy, Francesca Guarino, Sharada Gudur, Sharazeq Guettari, Shivang Gulati, Vikas Gulia, Pumali Gunasekera, Malin Gunawardena, Kirun Gunganah, Jessica Gunn, Emma Gunter, Alok Gupta, Atul Gupta, Rajeev Gupta, Richa Gupta, Rishi Gupta, Tarun Gupta, Vineet Gupta, Ankur Gupta-Wright, Victoria Guratsky, Alvyda Gureviciute, Sambasivarao Gurram, Bhawana Gurung, Shraddha Gurung, Hazel Guth, Ruth Habibi, Berkin Hack, Pamela Hackney, Christian Hacon, Aiman Haddad, Denise Hadfield, Michalis Hadjiandreou, Nikolaos Hadjisavvas, Leah Hadzik, Anna Haestier, Nauman Hafiz, Rana Hafiz-Ur-Rehman, Javed Hafsa, Samantha Hagan, Jack W Hague, Rosemary Hague, Kate Haigh, Christina Haines, Scott Hainey, Morton Hair, Brigid Hairsine, Juraj Hajnik, Anne Haldeos, Writaja Halder, Jennie Hale, Carmel Halevy, Paul Halford, William Halford, Alistair Hall, Anthony Hall, Claire Hall, Elizabeth Hall, Emma Hall, Fiona Hall, Helen Hall, Jennifer Hall, Kathryn Hall, Bill Hall, Jan Hallas, Kyle Hallas, Charles Hallett, Becky-Lee Halls, Heather Halls, Maryam Hamdollah-Zadeh, Bilal Hameed, Imran Hamid, Mohamad Hamie, Bethany Hamilton, Fergus Hamilton, Leigh Hamilton, Nicola Hamilton, Ruth Hamlin, Eleanor Hamlyn, Beatrice Hammans, Shirley Hammersley, Kate Hammerton, Bev Hammond, Leah Hammond, Sara Hammond, Fiona Hammonds, Ibrahim Hamoodi, Karen Hampshire, Elizabeth Hampson, Jude Hampson, Lucy Hampson, Ozan Hanci, Ian Hancock, Sadiyah Hand, Jasmine Handford, Soran Handrean, Sarah Haney, Sheharyar Hanif, E Hanison, Alison Hanlon, Jennifer Hannah, Amy Hannington, Merhej Hannun, Aidan Hanrath, Anita Hanson, Jane Hanson, Kathryn Hanson, Steve Hanson, Helen Hanwell, Mazhar Ul Haq, Ala Haqiqi, Monjurul Haque, Lesley Harden, Zoe Harding, Simon Hardman, Joanna Hardy, Kumar Haresh, Rachel Harford, Beverley Hargadon, Carolyn Hargreaves, Emily Hargreaves, James Hargreaves, Alice Harin, Mohammed Haris, Edward Harlock, Sandra Harlow, Paula Harman, Tracy Harman, Mark Harmer, Muhammad A Haroon, Charlie Harper, Fiona Harper, Heather Harper, Melanie Harper, Peter Harper, Rosemary Harper, Sarah Harrhy, Sian Harrington, Yasmin Harrington-Davies, Jade Harris, Jess Harris, John Harris, Laura Harris, Marie-Clare Harris, Naomi Harris, Nichola Harris, Sophie Harris, Alex Harrison, David Harrison, Julie Harrison, Laura Harrison, Melanie Harrison, Rowan Harrison, Susie Harrison, Thomas Harrison, Wendy Harrison, Elizabeth Harrod, Ciaran Hart, Dominic Hart, Lisa Hartley, Rosemary Hartley, Ruth Hartley, Tom Hartley, William Hartrey, Phillipa Hartridge, Stuart Hartshorn, Heli Harvala, Alice Harvey, Angela Harvey, Max Harvey, Catherine Harwood, Helen Harwood, Brigitte Haselden, Kazi Hashem, Mohammed Hashimm, Tadaaki Hashimoto, Imranullah Hashmi, Sarah Haskins, Zena Haslam, Adil Hassan, Ali Hassan, Wagae UI Hassan, Waqar Ul Hassan, Sapna Hassasing, Jane Hassell, Philip Hassell, Alex Hastings, Bethany Hastings, Janice Hastings, Stephanie Hatch, Jonathan Hatton, Sheryl Haviland, May Havinden-Williams, Stefan Havlik, Daniel B Hawcutt, Kadean Hawes, Liz Hawes, Nicola Hawes, Annie Hawkins, Catherine Hawkins, Nancy Hawkins, Tanya Hawkins, Dan Hawley, Ed Hawley-Jones, Edward Haworth, Cathy Hay, Amna Hayat, Jamal Hayat, Mohamed-Riyal Hayathu, Tamsin Haydon, Anne Hayes, Jonas Hayes, Kate Hayes, Melony Hayes, Vanessa Hayes, Fiona Hayes, Patrick Hayle, Chloe Haylett, Antara Hayman, Melanie Hayman, Matthew Haynes, Richard Haynes, Rachel Hayre, Sarah Haysom, James Hayward, Patrick Haywood, Tracy Hazelton, Phoebe Hazenberg, Zhengmai He, Elizabeth Headon, Carrie Heal, Brendan Healy, Amy Hearn, Angela Heath, Rowan Heath, Diane Heaton, Kerry Hebbron, Gemma Hector, Andy Hedges, Katrine Hedges, Cheryl Heeley, Elaine Heeney, Rajdeep Heire, Ulla Hemmila, Cassie Hemmings, Scott 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Hill, Phoebe Hill, Uta Hill, Annette Hilldrith, Elizabeth Hillerby, Catherine Hillman-Cooper, Elisabeth Hilton, Zoe Hilton, Sarah Hinch, Marcus Hinde, Andrew Hindle, Alice Hindmarsh, Paul Hine, Kim Hinshaw, Clare Hird, Alison Hirst, Jemma Hives, Benson Ho, Michaela Hoare, David Hobden, Gill Hobden, Maria Hobrok, Simon Hobson, Renate Hodge, Simon Hodge, Lesley Hodgen, Holly Hodgkins, Louise Hodgkinson, Sally Hodgkinson, David Hodgson, Helen Hodgson, Luke Hodgson, Sheila Hodgson, Gemma Hodkinson, Kenneth Hodson, Matthew Hogben, Lucy Hogg, Lee Hoggett, Abigail Holborow, Catherine Holbrook, Catherine Holden, Melinda Holden, Thomas Holder, Niels Holdhof, Hannah Holdsworth, Lisa Holland, Maureen Holland, Nicky Holland, Marie Hollands, Elizabeth Holliday, Nina Holling, Gillian Hollis, Laszlo Hollos, Linda Holloway, Simon Holloway, Marcus Hollyer, Amy Holman, Ann Holmes, Benjamin Holmes, Megan Holmes, Raphael Holmes, Rebecca Holmes, Kelly Holroyd, Caroline Holt, Lyndsey Holt, Siobhan Holt, Susie Holt, Alexandra Holyome, Marie Home, Toni Home, Renate Homewood, Kate Hong, Laura Hontoria del Hoyo, Clare Hooper, Sarah Hoosdally, Samantha Hope, Susan Hope, Bridget Hopkins, Peter W Horby, Stephanie Horler, Anil Hormis, Daniel Hornan, Nicola Hornby, Zoey Horne, Latoya Horsford, Megan Horsford, Mark Horsford, Valana Horsham, Alexander Horsley, Ashley Horsley, Elizabeth Horsley, Sarah Horton, Nicola Horton-Turner, Jane Hosea, Toby Hoskins, Muhammad S Hossain, Rashed Hossain, Leanne Hostler, Maxine Hough, Sarah Hough, Brittany Houghton, Catherine Houghton, Iain Houghton, Kathryn Houghton, Rebecca Houlihan, Angela Houston, Hamish Houston, Tawedzegwa Hove, Roseanna Hovvels, Lee How, Laura Howaniec, Laura Howard, Linda Howard, Lucy Howard, Sarah Howard, Stuart Howard, Richard Howard-Griffin, Alison Howarth, Diane Howarth, Serena Howe, Mark Howells, Lyn Howie, Kerry Howlett, Sophie Howlett, Joanne Hoyle, Josh Hrycaiczuk, Naing Zaya Htoon, Su Htwe, Ying Hu, Chiang Ooi Huah Huah, Abby Huckle, Shahzya Huda, Alison Hudak, Lisa Hudig, Alex Hudson, Cara Hudson, Heather Hudson, Peter Hudson, Oli Hudson, Alison Hufton, Connor Huggins, Alistair Hughes, Eithne Hughes, Emma Hughes, Gareth Hughes, Heather Hughes, Luke Hughes, Rachel Hughes, Rebecca Hughes, Samantha Hughes, Stephen Hughes, Vikki Hughes, Wesley Hughes, Lukas Huhn, Ching Hui, Ruth Hulbert, Diana Hull, Grace Hull, Robert Hull, Amanda Hulme, Peter Hulme, Wendy Hulse, George Hulston, Ryan Hum, Laura Humber, Megan Hume, Charlotte Humphrey, Ismay Humphreys, Alasdair Humphries, Joanne Humphries, Lena Hunold, Fiona Hunt, Kristen Hunt, Luke Hunt, Sophie Hunt, Al Hunter, Alexandra Hunter, Isobel Hunter, Karl Hunter, Neil Hunter, George Huntington, Elizabeth Hurditch, Cian Hurley, Katrina Hurley, Mohammed A Husain, Syeda Yusra Husaini, Coralie Huson, Afreen Hussain, Ibraar Hussain, Ifza Hussain, Mohammad Hussain, Muhammad Hussain, Reda Hussain, Sajid Hussain, Samia Hussain, Sanniah Hussain, Wasim Hussain, Yasmin Hussain, Mohammed Hussam El-Din, Raheem Hussein, Rebecca Hussey, Camille Hutchinson, Dorothy Hutchinson, Elizabeth Hutchinson, John Hutchinson, Claire Hutsby, Paula Hutton, Daniella Hydes, Jamie Hyde-Wyatt, Niamh Hynes, Megan Hyslop, Mazen Ibraheim, Abdalla Ibrahim, Ahmed Ibrahim, Asil Ibrahim, Mohamed Ibrahim, Monzeer Ibrahim, Wadah Ibrahim, Adetokunbo I Idowu, Muhammad Idrees, Hina Iftikhar, Mawara Iftikhar, Chukwuemeka Igwe, Mohammad Ijaz, Amaju Ikomi, Clare Iles, Stamatina Iliodromiti, Mary Ilsley, Lorna Ilves, La'ali Imam-Gutierrez, Christopher Imray, Alison Imtiaz, Haider Imtiaz, Claire Ingall, Jack Ingham, Julie Ingham, Rory Ingham, Tejas Ingle, Jennifer Inglis, Anne Ingram, Luke Ingram, Peter Inns, Ken Inweregbu, Andreea A Ionescu, Ana Ionita, Ilian P Iordanov, Anil Ipe, Adil Iqbal, Madiha Iqbal, Mohammed Iqbal, Faisal Iqbal Sait, Jane Ireland, Robert Irons, Mohannad Irshad, Muhammad S Irshad, Janice Irvine, Val Irvine, Pamela Irving, Robert Irving, Mina Ishak, Erica Isherwood, Aminul Islam, Abdurrahman Islim, Ali Ismail, Omar Ismail, Caroline Ison, M'hamedi Israa, Sharon Isralls, Ali Issa, Monica Ivan, Catrina Ivel, Chineze Ivenso, Ashleigh Ivy, Sophie Iwanikiw, Karen Ixer, Menaka Iyer, Mia Iyer, Calum Jack, Amanda Jackson, Anthony Jackson, Ben Jackson, Beth Jackson, Douglas Jackson, Ella Jackson, Hayley Jackson, Helen Jackson, Jane Jackson, Julie Jackson, Karin Jackson, Lauren Jackson, Melanie Jackson, Nicola Jackson, Shane Jackson, Sharon Jackson, Nikita Jacob, Patricia Jacob, Reni Jacob, Nicola Jacques, Terri-Lisa Jacques-Brown, Anisa Jafar, Daniel Jafferji, Ali Jaffery, Chandrashekar Jagadish, Vijay Jagannathan, Sam Jaggard, Mandeep Jagpal, Fernandez R Jaime, Neemisha Jain, Seema Jain, Susan Jain, Sanjay Jaiswal, Danyal Jajbhay, Thomas Jaki, Bintou Jallow, Yusuf Jaly, Sabine Jamal, Zeba Jamal, Yasmin Jameel, Albie James, Christie James, Kate James, Lee James, Linda James, Mark James, Nicholas James, Olivia James, Rebecca James, Ruth James, Tracy James, Jack Jameson, Aaron Jamison, Phoebe Jane, Azara Janmohamed, Sabrina Jansz, Deepa Japp, Lorraine Jappy, Victor Jardim, Catherine Jardine, Emma Jarnell, Ellie Jarvie, Ann Jarvis, Claire Jarvis, Lisa Jarvis, Rosina Jarvis, Patrycja Jastrzebska, Hafsa Javed, Mays Jawad, Lona Jawaheer, Kauky Jawaid, Anu Jayachandran, Dinakaran Jayachandran, Angelina Jayakumar, Deepak Jayaram, Ravi Jayaram, Geeshath Jayasekera, Thilina Jayatilleke, Abi Jayebalan, Saman Jeddi, Vandana Jeebun, Mohammad S Jeelani, Zeynab Jeewa, Emma Jefferson, Katie Jeffery, Helen Jeffrey, Jenni Jeffrey, Rachel Jeffrey, Sue Jeffrey, Nathan Jeffreys, Benjamin Jeffs, Debbie Jegede, Taylor Jemima, Ifan Jenkin, Alison Jenkins, Christopher Jenkins, David Jenkins, Elinor Jenkins, Sarah Jenkins, Sian Jenkins, Stephen Jenkins, Jacqui Jennings, Louise Jennings, Rebecca Jennings, Virginia Jennings, Ellen Jerome, Douglas Jerry, Ellen Jessup-Dunton, Jorge Antonio Jesus Silva, Champa Jetha, Kishan Jethwa, Jeby Jeyachandran, Visuvanathan Jeyakumar, Dharshana Jeyapalan, Shaman Jhanji, Khoo Jian, Zhixin Jiao, Laura Jimenez, Ana Jimenez Gil, Jithin Jith, Teishel Joefield, Navraj Johal, Karine Johannessen, Aisyah Johari, Annie John, Anu John, Navin John, Sarah John, Emma Johns, Margaret Johns, Anne-Marie Johnson, Antoinette Johnson, David Johnson, Emma Johnson, Gillian Johnson, Kathryn Johnson, Katie Johnson, Luke Johnson, Mark Johnson, Nelsonseelan Johnson, Oliver Johnson, Rachel Johnson, Tracy Johnson, Zoe Johnson, Claire Johnston, Janet Johnston, Laura Johnston, Susan Johnston, Victoria Johnston, Dawn Johnstone, Ed Johnstone, Janet Johnstone, Manohar Joishy, Adam Jones, Alistair Jones, Annabel Jones, Ben Jones, Bryony Jones, Carys Jones, Ceri Jones, Charlotte Jones, Christine E Jones, Debra Jones, Emily Jones, Gareth Jones, Geraldine Jones, Hazel Jones, Jac Jones, James Jones, Jamie Jones, Jessica Jones, Jonathon Jones, Julie Jones, Karen Jones, Kate E Jones, Kevin Jones, Laura Jones, Laura M Jones, Lorna Jones, Louise Jones, Mathew Jones, Nicola Jones, Paul Jones, Rhianna Jones, Ruth E Jones, Samantha Jones, Sophie Jones, Stefanie Jones, Steve Jones, Taya Jones, Tim Jones, Tracey Jones, Ramya Jonnalagadda, Rebecca Jordache, Annette Jose, Sanal Jose, Anna Joseph, Joseph Joseph, Rosane Joseph, Sibet Joseph, Dhaara Joshi, Mehul Joshi, Pratichi Joshi, Revati Joshi, Benz Josiah, Tiffany Joyce, Adriel Ju Wen Kwek, Edward Jude, Parminder Judge, Jessica Juhl, Sirisha Jujjavarapu, Mark Juniper, Edmund Juszczak, Deepthi Jyothish, Kasamu Kabiru Dawa, Mark Kacar, Katarina Kacinova, Nikhil Kadam, Rebecca Kahari, Gail Kakoullis, Azad Kala Bhushan, Richard JK Kalayi, Roobala Kaliannan Periyasami, Efthymia Kallistrou, Seika Kalsoom, Elisa Kam, John Kamara, Mohamed Kamara, Ajay Kamath, Prakash Kamath, Ravindra Kamath, Siddharth Arun Kamerkar, Nick Kametas, Musaiwale Kamfose, Arul Kandaswamy, Leia Kane, Osei Kankam, Thogulava Kannan, Abhinav Kant, Vikas Kapil, Ritoo Kapoor, Sonal Kapoor, Sourjya Kar, Janaka Kara, Vasita Kara, Marina Karakantza, Rona Kark, Nicholas Karunaratne, Natashja Kasianczuk, Vidya Kasipandian, Rizwan Kassam, Janarth Kathirgamachelvam, Victoria Katsande, Kulbinder Kaul, Daljit Kaur, Dervinder Kaur, Jasmin Kaur, Jaspreet Kaur, Satvinder Kaur, Zunaira Kausar, Mohammad AA Kawser, Andrea Kay, Sarah Kay, Jossy N Kayappurathu, Callum Kaye, Ahemd Kazeem, Naved Kazi, Sharon Kaznica, Samantha Kearley, Rachel Kearns, Nichola Kearsley, Joanne Keating, John Keating, Liza Keating, Elizabeth Keddie-Gray, Katie Keen, Natalie Keenan, Jonathan Kefas, Stephen Kegg, Laura Keith, Uzoamaka Keke, Tosin Kelani, Joanne Kellett, Jeremy Kellington, Alison Kelly, Conor Kelly, David Kelly, Diane Kelly, Dominic Kelly, Emma Kelly, Laura Kelly, Martin Kelly, Michael Kelly, Rosalind Kelly, Sinead Kelly, Stephen Kelly, Thomas Kelly, Mary Kelly-Baxter, Marketa Keltos, Timothy Kemp, Kelly Kemsley, Alexandra Kendall-Smith, Sarah Kennard, Ann Kennedy, Caroline Kennedy, James Kennedy, Sophie Kennedy-Hay, Julia Kenny, Kelly Kent, Melanie Kent, Lynne Keogan, Alexander Keough, Clement Kerlin, A Kerr, Andrew Kerr, Maria Kerr, Caroline Kerrison, Anthony Kerry, Samantha Kershaw, Helen Kerslake, Ian Kerslake, Helen Kerss, Jocelyn Keshet-Price, Margaret Kevern, Georgina Keyte, Abdul Khadar, Ali Khalid, Muhammad U Khalid, Syed Khalid, Amir Khalil, Asma Khalil, Sijjad Khalil, Abubakar Khan, Ali Khan, Al-Imran Khan, Arham Khan, Asad Khan, Aurangzeb Khan, Burhan Khan, Camran Khan, Fatimah Khan, Kausik Khan, Malik Aamaz Khan, Marria Khan, Mehrunnisha Khan, Mohammad Khan, Mohammed Khan, Nayeem Khan, Omar Khan, Rahe Khan, Rahila Khan, Sabiya Khan, Shabana Khan, Shahul Khan, Shoaib Khan, Tasaduksultan Khan, Waseem Khan, Usman F Khatana, Jibran Khatri, Jyoti Khatri, Hafiza Khatun, Taslima Khatun, Mena Kheia, Jacyntha Khera, Htet Ei Khin, Najaf Khoja, Kiran Khokhar, Jayne Khorsandi, Chloe Khurana, Faith Kibutu, Andrew Kidd, Michelle Kidd, Joe Kidney, Shane Kidney, Will Kieffer, James Kilbane, Caroline Kilby, Eileen Killen, Susan Kilroy, Bomee Kim, Jee Whang Kim, Sarah Kimber, Andy King, Barbara King, Jennifer King, Kirsten King, Rachel King, Sarah King, Tony King, Victoria King, Emily King-Oakley, Laura Kingsmore, Andy King-Venables, Fiona Kinney, Sidra Kiran, Jeremy Kirk, Jodie Kirk, Daniel Kirkbride, Amy Kirkby, Ian Kirker, Emily Kirkham, Gemma Kirkman, Ursula Kirwan, Kelly Kislingbury, Toby Kitching, Laura Kitto, Lauren Kittridge, Sarah Klaczek, Frieder Kleemann, Susan Kmachia, Chris Knapp, Lucy Knibbs, Alicia Knight, Fraser Knight, Marian Knight, Sarah Knight, Steven Knight, Tom Knight, Ellen Knights, Jane Knights, Toby Knights, Martin Knolle, Carol Knott, Charlotte Knowles, Karen Knowles, Laurence Knowles, Emily Knox, Lucy Knox, Oliver Koch, Ronan Kodituwakku, Gouri Koduri, Aisha Koirata, Eirene Kolakaluri, Magdalena Kolodziej, Eirini Kolokouri, Keith Kolsteren, Samantha Kon, Niladri Konar, Mari Kononen, Athanasios Konstantinidis, Hui Fen Koo, Imogen Koopmans, Emmanuela Kopyj, Laura Korcierz, James Korolewicz, George Koshy, Chris Kosmidis, Jalpa Kotecha, Easwari Kothandaraman, Leonidas Koukouflis, Koushan Kouranloo, Rukhsana Kousar'c, Margarita Kousteni, Maja Kovac, Alex Kozak Eskenazia, Kestutis Krasauskas, Raghu Krishnamurthy, Vinodh Krishnamurthy, Manju Krishnan, Hari Krishnan, Suzanne Krizak, Sean Krupej, Agnieszka Kubisz-Pudelko, Soren Kudsk-Iversen, Aurimas Kudzinskas, Chirag Kukadiya, Nainesha Kulkarni, Aditi Kumar, Mayur Kumar, Ramesh Kumar, Ravi Kumar, Rita Kumar, Rupa Kumar, Satish Kumar, Vimal Kumar, Arun Kundu, Heinke Kunst, Amit Kurani, Mohammed Kurdy, Rincy Kurian, Vimal Kurmars, Cameron Kuronen-Stewart, Ranganai S Kusangaya, Vlad Kushakovsky, Mandy Kuunal, Apexa Kuverji, Amma Kyei-Mensah, Thyra Kyere-Diabour, Moe Kyi, Nyan M Kyi, Laura Kyle, Karali-Tsilimpari Kyriaki, Julius Labao, Louise Lacey, Nikki Lack, Emma Ladlow, Heather Lafferty, Shondipon Laha, Sushil Lahane, Clement Lai, James Lai, Emma Laing, Robert Laing, Inez Laing-Faiers, Emily Laity, Michelle Lake, Nicki Lakeman, David Lalloo, Fiona Lalloo, Alison Lam, Fiona Lamb, Lucy Lamb, Thomas Lamb, Nick Lambe, Pauline Lambert, Claudia Lameirinhas, Mohammed KG Lami, Abigail Lamikanra, Holly Lamont, Michal Lamparski, Djillali Lamrani, Christine Lanaghan, Rebecca Lanaway, Ivone Lancona-Malcolm, Julia Lancut, Geraldine Landers, Martin J Landray, Matthew Lane, Nicholas Lane, Alidih Lang, Stephen Lang, Daniel Langer, Margaret Langley, Charles Langoya, Emily Langthorne, Taiya Large, Wojciech Lason, Anna Last, Scott Latham, John Latham-Mollart, Afzal Latheef, Darren Latimer, Nang Latt, Carly-Jane Lattimore, Dawn Lau, Eva Lau, Myra Laurenson, Hou Law, Jennifer Law, Jessica Law, Penny Law, Richard Law, Colin Lawler, Mark Lawley, Emma Lawrence, Jo Lawrence, Neil Lawrence, Ryan Lawrie, Jemima Lawson, Joanne Lawson, Louise Lawson, Rebecca Lawton, Michael Lay, Christine Laycock, Reina Layug, Maria Lazo, Vietland Le, Amelia Lea, William Lea, Ian Leadbitter, Thomas Leahy, Richard Lean, Lorna Leandro, Darren Leaning, Sandra Leason, Christina Leaver, Marie Anne Ledingham, Emma Lee, Hannah Lee, Irish Lee, Judith Lee, Sam Lee, Shi Han Lee, Simon Lee, Sindy Lee, Stephanie Lee, Tracey Lee, Xiang Lee, Diana Lees, Jennifer Lees, Helen Legge, Julian Leggett, Katie Leigh-Ellis, Kevan Leighton, Nicky Leitch, Eleni Lekoudis, Petula Lemessy, Nicholas Lemoine, Joana Lemos, Irina Lenchuk, Katy Leng, Katrina Lennon, Liz Lennon, Isabel Lentell, Kelly Leonard, Wen Leong, Nicky Leopold, Oskar Lepiarczyk, Isla Leslie, Eleni Lester, Joe Leung, Ullrich Leuschner, Emma Levell, Chris Levett, Alice Lewin, Michaela Lewin, Alison Lewis, David Lewis, Dee Lewis, Georgina Lewis, Gillian Lewis, Joanne Lewis, Joseph Lewis, Kathryn Lewis, Keir Lewis, Leon Lewis, Lisa Lewis, Marissa Lewis, Rob Lewis, Robert Lewis, Catherine Lewis-Clarke, Lorraine Lewis-Prosser, Katherine Lewiston, Adam Lewszuk, Penny Lewthwaite, Samantha Ley, Anna Li, Jenny Li, Angela Liao, Victoria Licence, David Lieberman, Susan 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Kateryna Macconaill, Chloe Macdonald, Stuart MacDonald, Tania MacDonald, Claire Macfadyen, James G Macfarlane, Jill Macfarlane, Laura Macfarlane, Cara MacGuigan, Lisa MacInnes, Iain MacIntyre, Jill MacIntyre, Kirsten Mack, Callum Mackay, Euan Mackay, Laura Mackay, Alexander Mackenzie, Matt Mackenzie, Robert MacKenzie Ross, Ami Mackey, Patricia Mackey, Fiona Mackie, Robert Mackie, Carolyn Mackinlay, Claire Mackintosh, Katherine Mackintosh, Sheila MacLennan, Mary Joan MacLeod, Michael Macmahon, Andrew MacNair, Catherine Macphee, Iain Macpherson, Catriona Macrae, Allan MacRaild, Eilidh MacVean, Alannah Madden, Mary Madden, Norman Madeja, Karen Madgwick, Pradeep Madhivathanan, Madhavi Madhusudhana, Harriet Madiyiko, Alpha Madu, Lorraine Madziva, Marion Mafham, Nick Magee, Frederick Magezi, Tim Maggs, Negar Maghsoodi, Christopher Magier, Marios Magriplis, Kathryn Maguire, Natasha Mahabir, Subramanian Mahadevan-Bava, Anjanie Maharajh, Ajit Mahaveer, Bal Mahay, Kanta Mahay, Hibo Mahdi, Thushika Mahendiran, Siva Mahendran, Sarah Maher, Anistta Maheswaran, Shameera Maheswaran, Tina Maheswaran, Parisa Mahjoob-Afag, Ahmed Mahmood, Farhana Mahmood, Waheed Mahmood, Zahra Mahmood, Hager Mahmoud, Ewan Mahony, Luke Mair, Toluwani Majekdunmi, Kesson Majid, Rupert Major, Jaydip Majumdar, Mohammad KH Majumder, Stephen Makin, Marius Malanca, Hannah Malcolm, Flora Malein, Neeraj Malhan, Ayesha Malik, Gulshan Malik, Mohammed Maljk, Paul Mallett, Petrina Mallinder, Georgia Mallison, Louise Mallon, Edward Malone, Gracie Maloney, Edgar Malundas, Madhu Mamman, Irene Man, Kathy Man, Rossana Mancinelli, Marco Mancuso-Marcello, Tracy Manders, Lauren Manderson, Justin Mandeville, Roope Manhas, Carmen Maniero, Ravi Manikonda, Bobby Mann, Jonathan Manning, Lynne Mannion, Katherine Mansi, Katarina Manso, Dina Mansour, Isheunesu T Mapfunde, Predeesh Mappa, Hemant Maraj, Garikayi Marange, Lisa March, Clare Marchand, Neil Marcus, Maria Marecka, Gomathi Margabanthu, Jordi Margalef, Lavinia Margarit, Georgios Margaritopoulos, Mike Margarson, Fernandez M Maria del Rocio, Teresa Maria Pfyl, Victor Mariano, Helen Maria-Osborn, Ashleigh Maric, Grace Markham, John Markham, Maria Marks, Pamela Marks, Elisabeth Marouzet, Arran Marriott, Cheryl Marriott, Nemonie Marriott, Brian Marsden, Karen Marsden, Paul Marsden, Sarah Marsden, Tracy Marsden, Robyn Marsh, Adam Marshall, Andrew Marshall, Gail Marshall, Henry Marshall, Jaimie Marshall, James Marshall, Jenna Marshall, Nicola Marshall, Riley Marshall, Jennifer Marshall, Samantha Marston, Emmeline Martin, Hayley Martin, Hope Martin, Jane Martin, Karen Martin, Kate Martin, Laila Martin, Michael Martin, Noelia Martin, Tim Martin, Winston Martin, Sarah Martin, Tim Martindale, Marcus Martineau, Alexander Martinez, Lauren Martinez, Jose Carlos Martinez Garrido, Juan Martin-Lazaro, Olivia Martins, Lucas Martins Ferreira, Vijay Kumar Maruthamuthu, Gemma Maryan, Roman Mary-Genetu, Sam Maryosh, Vidan Masani, Diego Maseda, Sheila Mashate, Yasaman Mashhoudi, Al Mashta, Izhaq Masih, Sanna Masih, Nick Maskell, Perry Maskell, Matthew Masoli, Lynn Mason, Rebecca Mason, Richard Mason, Ruth Mason, Claire Mason, Mohammad Masood, Mohammad T Masood, Syed Masood, Syed SME Masood, Aaqib Masud, Lear Matapure, Cristina Matei, Ropafadzo Matewe, Manraj Matharu, Stephy Mathen, Alex Mather, Nicole Mather, Jonathan Mathers, Joanna Matheson, Amal Mathew, Anna Mathew, Moncy Mathew, Verghese Mathew, Caroline Mathews, Jesha Mathews, Kate Mathias, Marion Mathie, Darwin Matila, Wadzanai Matimba-Mupaya, Nashaba Matin, Elina Matisa, Max Matonhodze, Elijah Matovu, Jaysankar Mattappillil, Alison J Matthews, Heather Matthews, Helen Matthews, Sue Matthews, Gwynn Matthias, Fiona Maxton, Adam Maxwell, Gemma Maxwell, Veronica Maxwell, James May, Joanne May, Oliver May, Philippa May, Irving Mayanagao, Matthew Maycock, Graham Mayers, Lee Maynard, Shelley Mayor, Ibreaheim Mazen, Andrea Mazzella, Nyambura Mburu, Mercy Mbwembwe, Martyn McAdam, Eleanor McAleese, Helinor McAleese, Paul McAlinden, Audrey McAlpine, Graeme McAlpine, Jonathan McAndrew, Hamish McAuley, Sarah McAuliffe, Claire McBrearty, Carole McBride, Erin McBride, Michael McBuigan, James McBurney, Laura McCabe, Amanda McCairn, Martina McCalmont, Jake McCammon, Nicole McCammon, Conor McCann, Alexandra McCarrick, Brendan McCarron, Eoghan McCarthy, Michelle McCarthy, Natalie McCarthy, Sinead McCaughey, Gareth McChlery, Tara McClay, Beverley McClelland, Declan McClintock, Patricia McCormack, Jacqueline McCormick, Wendy McCormick, Paul McCourt, Jame McCrae, Sharon McCready, Allison McCreath, Gordan McCreath, Helen McCreedy, Louise McCreery, Iain J McCullagh, Josephine McCullagh, Liz McCullagh, Megan McCullagh, Conor McCullough, Katherine McCullough, Nicola McCullough, Sarah McCullough, Fiona McCurrach, Rory McDermott, Katharine McDevitt, Helen McDill, Basil McDonald, Claire McDonald, Debbie McDonald, Rob McDonald, Sam McDonald, Damhnaic McDonald, Rowan McDougall, Irene 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Mollet, Malid Molloholli, Aoife Molloy, April Molloy, Linda Molloy, Andrew Molyneux, Tasnim Momoniat, Holly Monaghan, Josephine Monaghan, Krista Monaghan, Shiva Mongolu, Katelyn Monsell, Mahmoud Montasser, Alan Montgomery, Hugh Montgomery, Prebashan Moodley, Ian Moody, Margaret Moody, Nick Moody, Angela Moon, James Moon, Ji-Hye Moon, Maria Moon, May Moonan, Parvez Moondi, Alex Moore, Carly Moore, Christopher Moore, Davidjar Moore, Faye Moore, Gillian Moore, Hannah Moore, Judith Moore, Laura Moore, Sally Moore, Sonia Moore, Tracy Moore, Rachel Moores, Ed Morab, Jose Morales, Nuria Moramorell, Louise Moran, Grishma Moray, Jeronimo Moreno-Cuesta, Adam Morgan, Amy Morgan, Christine Morgan, Colin Morgan, Jackie Morgan, Lauren Morgan, Leila Morgan, Matthew Morgan, Patrick Morgan, Katie Morgan-Jones, Emily Morgan-Smith, Anna Morley, Thomas Morley, Wendy Morley, Anna Morris, Damian Morris, Fiona Morris, Helen Morris, Juliet Morris, Katie Morris, Laura Morris, Lucy Morris, Mary-Anne Morris, Niall Morris, Paul Morris, Sheila Morris, Susan Morris, Douglas Morrison, Moira Morrison, Mary Morrissey, Anna Morrow, Chantal Morrrell, Franca Morselli, Gordon Mortem, Chelsea Morton, Gordon Morton, Rosna Mortuza, Priti Morzaria, Alison Moss, Charlotte Moss, Rachel Moss, Sarah Moss, Stuart Moss, Nicki Motherwell, Johanna Mouland, Caroline Moulds, Hilary Moulton, Lorraine Mounsey, Elizabeth Mousley, Karen Moxham, Borja Moya, Quberkani Moyo, Eunice Mshengu, Sheila Mtuwa, Ali Muazzam, Iqtedar A Muazzam, Nykki Muchenje, Dalia Mudawi, Girish Muddegowda, Imran Mugal, Ahsan Mughal, Javaid Muglu, Javed Muhammad, Alison Muir, Carol Muir, Martin Muir, Dipak Mukherjee, Syed Asim Ali Mukhtar, Denise Mukimbiri, Tshinupay Mukwa, Peter Mulgrew, Ben Mulhearn, Arafat Mulla, Dee Mullan, Dileepkumar Mullasseril Kutten, Niall Mullen, Rosemary Mullett, Sandra Mulligan, Barbara Mullin, Joanne Mullings, Lana Mumelj, Andrew Mumford, Sarah Mumford, Mohammed Munavvar, Henry Munby, Anne-Marie Munro, Sheila Munt, Nafissah Munu, McDonald Mupudzi, Arshid Murad, Oluwatosin H Muraina, Koteshwara Muralidhara, Diane Murdoch, Mhairi Murdoch, Jennifer Murira, Alison Murphy, Carl Murphy, Emily Murphy, Fidelma Murphy, Gail Murphy, Jo Murphy, Peter Murphy, Sheenagh Murphy, Simon Murphy, Clare Murray, David Murray, Eleanor Murray, Katie Murray, Kenneth Murray, Lisa Murray, Lorna Murray, Tracey Murray, Eoin Murtagh, Mithun Murthy, Catherine Murton, Rosie Murton, Neeka Muru, Rosemary Musanhu, Maimuna Mushabe, Kaiser Mushtaq, Omaisa Mushtaq, Ahmed M Mustafa, Elhaytham Mustafa, Mustafa Mustafa, Ibrahim Mustapha, Zhain Mustufvi, Callum Mutch, Eric Mutema, Balakumar Muthukrishnan, Sheree Mutton, Natasha Muzengi, Memory Mwadeyi, Bettina Mwale, Esther Mwaura, Raji Myagerimath, Alice Myers, Sam Myers, Khin Swe Myint, Yadee Myint, Libor Myslivecek, Helen Nabakka, Evelyn Nadar, Iftikhar Nadeem, Moosa Nadheem, Asma Naeem, Hassan Naeem, Salman Naeem, Samraiz Nafees, Mohamed Nafei, Parminder Naga, Thapas Nagarajan, Imrun Nagra, Deepak Nagra, Mina Naguib, Kirushthiga Naguleswaran, K Shonit Nagumantry, Kevin Naicker, Sarveshni Naidoo, Gireesha Naik, Rishi Naik, Samir Naik, Devu S Nair, Rajiv Nair, Tanushree Nair, Jay Naisbitt, Kerry Naismith, Sri Nallapareddy, Soum Nallapeta, Arumugan Nallasivan, Uttam Nanda, Aarti Nandani, Ali Raza Naqvi, Asadullah Naqvi, Sara Naqvi, Shruthi Narayan, Sophia Nasa, Dominic Nash, Nader Nasheed, Abdul Nasimudeen, Umer Nasir, Marwan Nassari, Tahir Nasser, Anushka Natajaran, Anuja Natarajan, Geetha Natarajan, Nalin Natarajan, Nikhila Natarajan, Rajkumar Natarajan, Noel Nathaniel, Mala Nathvani, Priyan Nathwani, George Nava, Neena Navaneetham, Jeya Navaratnam, Helen Navarra, Sadaf Naveed, John Navin, Khuteja Nawaz, Sarfaraz Nawaz, Shasta Nawaz, Bonilla Nayar, Suzanne Naylor, Moez Nayyar, Farrah Naz, Mobeena Naz, Salima Nazarali, Babak Nazari, S Nazir, Sehar Nazir, Dumisani Ncomanzi, Onyine Ndefo, Alan Neal, Elaine Neary, Mostafa Negmeldin, Paula Neill, Hector E Neils, Avideah Nejad, Louise Nel, Marie Nelson, Richard Nelson, Scott Nelson, Rajesh Nemane, Samiksha Nepal, Daniel Nethercott, Kimberley Netherton, Kimberley Nettleton, Claire-Michelle Neville, Tracy Nevin, Josephine Newanji, Alison Newby, Angela Newby, David Newby, Tracy Newcombe, Charlotte Newman, Diana Newman, Julie Newman, Oscar Newman, Richard Newman, Tabitha Newman, Thomas Newman, Rachel Newport, Claire Newsam, Christopher Newson, Maria Newton, Anthony YKC Ng, Ka Wing Ng, Maxine Ng, Sarah Ng, Wee Jin Ng, Thomas Ngan, Gabriel CE Ngui, Alice Ngumo, Caoimhe Nic Fhogartaigh, Nathalie Nicholas, Philip Nicholas, Rachel Nicholas, Teresa Nicholas, Donna Nicholls, Lisa Nicholls, Alice Nicholson, Anne Nicholson, Annette Nicholson, Janet Nicholson, Ian Nickson, Eileen Nicol, Elizabeth Nicol, Rebecca Nicol, Pantelis Nicola, Antony Nicoll, Pantzaris Nikolaos, Georgii Nikonovich, Annette Nilsson, Kofi Nimako, Louise Nimako, Camus Nimmo, Preethy Ninan, Mahesh Nirmalan, Muhammad Nisar, Toby 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Sudershan, Lee Sudlow, Gayle Sugden, Peter Sugden, Rudresh Sukla, Ali Suliman, Fatimah Suliman, Ian Sullivan, Sugrah Sultan, Jennifer Summers, Mark Summerton, Samyukta Sundar, Reka Sundhar, Edmond Sung, Nadia Sunni, Jay Suntharalingam, Amitava Sur, Dharmic Suresh, Shilpa Suresh, Rachel Suri, Michael Surtees, Danielle Suter, Helen Sutherland, Rachel Sutherland, Rebecca Sutherland, Dovile Sutinyte, Deborah Sutton, John Sutton, Sam Sutton, Mihaela Sutu, Marie-Louise Svensson, Sima Svirpliene, Andrew Swain, Thomas Swaine, Christopher Swales, Lorna Swan, Nicola Swarbrick, Tirion Swart, Stephen Sweetman, Samaher Sweity, Ealish Swift, Paul Swift, Pauline Swift, Peter Swift, Rachael Swift, Rachel Swingler, Sophie Swinhoe, Katarzyna Swist-Szulik, Luke Swithenbank, Omair Syed, Catriona Sykes, Daisy Sykes, Eliot Sykes, Luke Sylvester, Dominic Symon, Andrew Syndercombe, Zoe Syrimi, Jen Syson, Gemma Szabo, Tamas Szakmany, Megan Szekely, Matthew Szeto, Maria Tadros, Amr Tageldin, Lucy Tague, Hasan Tahir, Muhammad Tahir, Silvia Taibo, Zsofia Takats, Abigail Takyi, Peter Talbot, Alison Talbot -Smith, James Talbot-Ponsonby, Richard Tallent, Bradley Tallon, Phoebe Tamblin-Hopper, Adrian Tan, Bee T Tan, Hock Tan, Huey Tan, Jade Tan, Keith Tan, WeiTeen Tan, Anand Tana, Xiaohui Tang, Christina Tanney, Tabitha Tanqueray, Emma Tanton, Ran Tao, Mark Taplin, Hayley Tarft, Priyal Taribagil, Obaid Tarin, Syed Tariq, Zeeshan Tariq, David Tarpey, Lisa Tarrant, Antonia Tasiou, Elizabeth Tatam, Margaret L Tate, Kate Tatham, Vera Tavoukjian, Alexander Taylor, Beverley Taylor, Brian Taylor, Charlie Taylor, Charlotte Taylor, David Taylor, Elisabeth Taylor, Janet Taylor, Jennifer Taylor, Joanne Taylor, Julie Taylor, Karen Taylor, Leanne Taylor, Margaret Taylor, Matthew Taylor, Melanie Taylor, Natalie Taylor, Rachael Taylor, Rachel Taylor, Samantha Taylor, Suzanne Taylor, Tina Taylor, Tracey Taylor, Vicky Taylor, Michelle Taylor-Siddons, Thomas Taynton, Amelia Te, Jessica Teasdale, Julie Tebbutt, 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Lucy Turner, Marc Turner, Mark Turner, Patricia Turner, Ruth Turner, Sally Turner, Samantha Turner, Susan Turner, Victoria Turner, Sharon Turney, Jon Turvey, Conor Tweed, David Tweed, Rebecca Twemlow, Emma Twohey, Bhavya Tyagi, Vedang Tyagi, Abigail Tyer, Jayne Tyler, Jennifer Tyler, Alison Tyzack, Petros Tzavaras, Mohammad S Uddin, Ruhama Uddin, Ruzena Uddin, Salamat Ullah, Sana Ullah, Sanda Ullah, Athavan Umaipalan, Judith Umeadi, Akudo Umeh, Wilfred Umeojiako, Ben Ummat, Charlotte Underwood, Jonathan Underwood, Laura Unitt, Adam Unsworth, Jasvinder Uppal, Veerpal S Uppal, James Uprichard, Gerry Upson, Masood Ur Rasool, Alison Uriel, Sebastian Urruela, Hiromi Uru, Miranda Usher, Rebecca Usher, Alex UsherRea, Andrew Ustianowski, Jane Uttley, Linda C Vaccari, Uddhav Vaghela, Abhay Vaidya, Bernardas Valecka, Jennifer Valentine, Balan Valeria, Pramodh Vallabhaneni, Pedro Valle Vallines, Luke Vamplew, Ekaterini Vamvakiti, Joannis Vamvakopoulos, Maud van de Venne, Alex van der Meer, Nora 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Holt Walters, James Walters, Jocelyn Walters, Eileen Walton, Lucy Walton, Olivia Walton, Sharon Walton, Susan Walton, Mandy Wan, Thin Wan, Mary Wands, Rachel Wane, Frank Wang, Nick Wang, Ran Wang, Deborah Warbrick, Samantha Warburton, Deborah Ward, Emma Ward, Joanna Ward, Karen Ward, Luke Ward, Nicola Ward, Rachael Ward, Rebecca Ward, Thomas Ward, Tom Ward, Scott A Warden, Adele Wardle, Karen Wardle, Steve Wardle, Hassan Wardy, Scott Waring, Jenny Warmington, Ben Warner, Christian Warner, Lewis Warnock, Sarah Warran, Jade Warren, Lisa Warren, Yolanda Warren, Hannah Warren-Miell, Gill Warwick, Charlotte Washington, Helen Wassall, Hazel J Watchorn, Holly Waterfall, Abby Waters, Donald Waters, Mark Waterstone, Catherine Watkins, Catrin Watkins, Eleanor Watkins, Karen Watkins, Lynn Watkins, Nick Watkins, Abigail Watson, Adam JR Watson, Ekaterina Watson, Eleanor Watson, Paul Watson, Rebecca Watson, Robert Watson, Sandra Watson, Malcolm Watters, Donna Watterson, Daniel Watts, John Watts, Merlin Watts, Victoria Waugh, Emma Wayman, Akhlaq Wazir, Mark Weatherhead, Nick Weatherly, Paul Weaver, Hayley Webb, Kathryn Webb, Kylie Webb, Stephen Webb, Cheryl Websdale, Deborah Webster, Ian Webster, Tim Webster, Kathleen Wedgeworth, Ling Wee, Rebecca Weerakoon, Thanuja Weerasinghe, Janaka Weeratunga, Maria Weetman, Shuying Wei, Immo Weichert, Hugh Welch, James Welch, Leanne Welch, Steven Welch, Samantha Weller, Lucy Wellings, Brian Wells, Susan Wellstead, Berni Welsh, Richard Welsh, Ingeborg Welters, Rachael Welton, Lauren Wentworth, Kate Wesseldine, James Wesson, Jim Wesson, Adam West, Magdelena West, Raha West, Ruth West, Sophie West, Luke Western, Ruth Westhead, Heather Weston, Alice Westwood, Bill Wetherill, Sharon Wheaver, Helen Wheeler, Ben Whelan, Matthew Whelband, Amanda Whileman, Alison Whitcher, Abbie White, Andrew White, Benjamin White, Christopher White, Duncan White, Emily White, James White, Jonathan White, Katie White, Marie White, Nick White, Sarah White, Sonia 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Alexandra Williams, Alison Williams, Angharad Williams, Ava Williams, Carl Williams, Caroline V Williams, Claire Williams, Dewi Williams, Gail Williams, Gemma Williams, Gina Williams, Hannah Williams, James Williams, Jayne Williams, Jennie Williams, John Williams, Joseph Williams, Karen Williams, Kathryn Williams, Marie Williams, Matthew Williams, Patricia Williams, Penny Williams, Rachael Williams, Rupert Williams, Samson Williams, Sarah Williams, Sophie Williams, Tamanna Williams, Annie Williamson, Cath Williamson, Catherine Williamson, Dawn Williamson, James D Williamson, Rachel Williamson, Helen Williamson, Bruce Willian, Elizabeth Willis, Emily Willis, Heather Willis, Herika Willis, Joanna Willis, Laura Willmott, Louise Wills, Lucy Willsher, Catherine Willshire, Francesca Willson, Alison Wilson, Andrea Wilson, Antoinette Wilson, Billy Wilson, Catherine Wilson, Eve Wilson, James Wilson, Karen Wilson, Kate Wilson, Lucinda Wilson, Mark Wilson, Matthew Wilson, Toni Wilson, Evie Wiltsher, Marlar Win, Tin Win, Wut Yee Win Win, Lucinda Winckworth, Laura Winder, Piers Winder, Phillip Windrum, Kerry Winham-Whyte, Helen Winmill, Simon Winn, Carmen Winpenny, Helen Winslow, Helen Winter, Jonathan Winter, Pascal Winter, Barbara Winter-Goodwin, Stephen Wisdom, Matthew Wise, Martin Wiselka, Rebecca Wiseman, Sophie Wiseman, Steven Wishart, Holly Wissett, Eric Witele, Nicholas Withers, Janet Wittes, Donna Wixted, Therese Wodehouse, Will Wolf, Nicola Wolff, Kirsten Wolffsohn, Rebecca Wolf-Roberts, Magda Wolna, Elena Wolodimeroff, Adam Wolstencroft, Alan Wong, Charlotte Wong, Chi-Hung Wong, Edwin Wong, Jessica Sue Yi Wong, Kit Y Wong, Lee Wong, Mei Yin Wong, Nick Wong, Sam Wong, Yun Man Wong, Amanda Wood, Caroline Wood, Carrie Anne Wood, Dianne Wood, Fiona Wood, Hannah Wood, Jennifer Wood, Joe Wood, Julia Wood, Kathryn Wood, Lisa Wood, Louise Wood, Michelle Wood, Stephen Wood, Tracy Wood, Ursula Wood, Katharine Woodall, Rebecca Woodfield, Christopher Woodford, Elizabeth Woodford, Jill Woodford, Luke Woodford, Louise Woodhead, Timothy Woodhead, Philip Woodland, Marc Woodman, Debra Woods, Jane Woods, Katherine Woods, Sarah Woods, Zoe Woodward, Rachel Wookey, Megan Woolcock, Gemma Wooldridge, Rebecca Woolf, Chris Woollard, Christopher Woollard, Louisa Woollen, Emma Woolley, Jade Woolley, Daniel Woosey, Dan Wootton, Joanne Wootton, Daniel Worley, Stephy Worton, Jonathan Wraight, Maria Wray, Tim Wreford-Bush, Joanne Wren, Kim Wren, Lynn Wren, Caroline Wrey Brown, Catherine Wright, Demi Wright, Francesca Wright, Imogen Wright, Lee Wright, Lianne Wright, Pete Wright, Rachel Wright, Rebecca Wright, Stephanie Wright, Tim Wright, Caroline Wroe, Hannah Wroe, Henry Wu, Peishan Wu, Pensee Wu, Jonathan Wubetu, Retno Wulandari, Craig Wyatt, Frederick Wyn-Griffiths, Inez Wynter, Bindhu Xavier, Arnold Xhikola, Zhongyang Xia, Huiyuan Xiao, Masseh Yakubi, May Yan, Freda Yang, Yingjia Yang, Michael Yanney, Woei Lin Yap, Nabil Yaqoob, Naairah Yaqub, Salima Yasmin, Bryan Yates, David Yates, Edward Yates, Helen Yates, Julie Yates, Mark Yates, Charlotte Yearwood Martin, Andrew Yeatman, Khin Yein, Fiona Yelnoorkar, Peter Yew, Kawai Yip, Laura Ylquimiche, Laura Ylquimiche Melly, Inez Ynter, H Yong, Jemma Yorke, Jasmine Youens, Abdel Younes Ibrahim, Eoin Young, Gail Young, Louise Young, Richard Young, Asfand Yousafzar, Sajeda Youssouf, Ahmed Yousuf, Chrissie Yu, Bernard Yung, Daniel Yusef, Said Yusef, Intekhab Yusuf, Anna-Sophia Zafar, Silvia Zagalo, Su Zaher, Aqsa Zahoor, Kareem Zaki, Nabhan Zakir, Kasia Zalewska, Ane Zamalloa, Mohsin Zaman, Raisa Zaman, Shakir Zaman, Julie Zamikula, Louise Zammit, Marie Zammit-Mangion, Lynn Zarb, Esther Zebracki, Daniel Zehnder, Lisa Zeidan, Marian Zelman, Xiaobei Zhao, Dongling Zheng, Doreen Zhu, Madiha Zia, Omar Zibdeh, Rabia Zill-E-Huma, Ei Thankt Zin, Veronica Zindonda, Eleanor Zinkin, Vivian Zinyemba, Christos Zipitis, Arkadiusz Zmierczak, Azam Zubir, Roslin Zuha, Naz Zuhra, Rasha Zulaikha, Sabrina Zulfikar, Carol Zullo, Ana Zuriaga-Alvaro, Will Zuurbier, Sheba Zyengi, and University of St Andrews. School of Medicine
Subjects: Male, Convalescent plasma, medicine.medical_treatment, 030204 cardiovascular system & hematology, Antibodies, Viral, Rate ratio, 0302 clinical medicine, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Medicine, Hospital Mortality, 030212 general & internal medicine, 11 Medical and Health Sciences, Aged, 80 and over, Medicine(all), Mortality rate, Covid19, Articles, 3rd-DAS, General Medicine, Middle Aged, Hospitals, Treatment Outcome, Female, Open label, Coronavirus Infections, Life Sciences & Biomedicine, RM, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), 03 medical and health sciences, Medicine, General & Internal, SDG 3 - Good Health and Well-being, General & Internal Medicine, Internal medicine, Humans, In patient, Pandemics, COVID-19 Serotherapy, Aged, Mechanical ventilation, Science & Technology, SARS-CoV-2, business.industry, Significant difference, Immunization, Passive, COVID-19, Length of Stay, NIS, R1, Respiration, Artificial, United Kingdom, RM Therapeutics. Pharmacology, RECOVERY Collaborative Group, business
Abstract: Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research.
Published: 2021

48. Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study

Author: Dmitri Nepogodiev, Richard JW Wilkin, Catherine J Bradshaw, Clare Skerritt, Alasdair Ball, Waaka Moni-Nwinia, Ruth Blanco-Colino, Priyesh Chauhan, Thomas M Drake, Matteo Frasson, Oliver Gee, James C Glasbey, Jacob H Matthews, Gabriella L Morley, David N Naumann, Francesco Pata, Antonio S Soares, Aneel Bhangu, SH Abbas, AM Abdelgadir, A Abdelrahman, M Abdelrahman, A Abdelwahed, Y Abou El Ella, M Abulafi, A Acharya, ME Adam, RE Adams, SO Adegbola, A Adimonye, M Adnan, S Afshar, A Ahad, J Ahel, DP Ahern, A Ahmad Asmadi, B Ahmed, G Ahmed, OS Ahmed, S Ahmed, K Akbari, O Akinsola, W Al-Khyatt, B Al-Sarireh, M Al-Sheikh, M Alani, R Alexander, T Alhammali, M Ali, A Aljorfi, M Allen, J Allington, A Alshafei, R Amarasinghe, A Amayo, V Amin, Thuva Amuthalingam, L Anandan, O Anderson, SM Andreani, B Andrews, A Ang, B Aravind, JE Archer, MA Aremu, S Arunachalam, N Aruparayil, DL Ashmore, O Ashour, N Ashraf, N Assaf, H Avalapati, OO Awokoya, J Ayube-Brown, T Badenoch, R Bagga, A Baginski, S Bailey, STR Bailey, C Baird, B Baker, EJ Balai, A Balasubramaniam, SK Bandyopadhyay, A Banks, H Bansal, W Barnieh, A Barrie, CA Barter, J Bastianpillai, WD Beasley, CR Bell, J Bell, D Beral, BJM Berry, KE Bevan, V Bevan, Shiv Bhanderi, A Bhargava, D Bilku, A Birindelli, OD Blackford, JEM Blackwell, L Blake, Natalie S Blencowe, TD Boam, C Boereboom, M Bogdan, P Bohra, JC Bolger, W Bolton, S Bond, CM Borg, K Borghol, PR Boshier, N Bouhadiba, J Bowen, H Bowerman, CR Bowman, H Boyd-Carson, CJ Bradshaw, G Branagan, P Brennan, M Brett, HK Brewer, H Brewer, C Bronder, A Brown, AG Brown, CE Brown, M Brown, R Brown, S Buckley-Jones, A Budzanowski, W Bukhari, C Bull, JK Bullivant, KM Burns, D Burnside, A Busuttil, BE Byrne, CK Byrnes, M Caldwell, R Callan, FC Cameron, U Campbell, UM Campbell, W Campbell, CA Carden, CFW Carder, K Carney, H Cartwright, P Cay, A Chalk, B Chambers, A Champsi, D Chan, TCW Chan, SB Chandler, J Chapman, A Charalabopoulos, B Chasty, M Chatzikonstantinou, WL Cheah, CS Chean, S Cheng, SA Cheng, M Cheruvu, MY Chin, IA Chishti, S Choi, SM Chok, B Chong, JH Choong, M Chowdhary, F Chowdhury, CH Choy, L Christian, P Christopoulos, K Chui, M Cipparrone, GL Clark, SA Clarke, SJ Cleeve, KD Clement, B Clements, C Clements, JD Clements, JM Clements, JS Clements, JA Clements, R Clingan, L Cloney, ECS Clough, PO Coe, O Collier-Wakefield, DW Colliver, DA Colvin, TM Connelly, MJ Connor, V Cook, F Cooke, F Cooper, AE Cotton, DG Couch, L Cousins, D Coyle, W Creasy, RL Cresner, A Crone, K Cross, J Crozier, P Cunha, NJ Curtis, N D'Souza, H Dagash, S Dalmia, I Daniels, D Danquah-Boateng, FA Dar, K Dart, A Das, R Daureeawoo, S Davidson, JR Davidson, PL Davies, S Davis, V Daya Shetty, A De-Manzoni-Garberini, JA De-Marchi, EA Dean, S Dean, C Delimpalta, S Denley, G Dennison, AA Devine, S Dharamavaram, AA Dhari, F Di Franco, S Di Saverio, C Dobson, JA Docherty, C Doherty, G Donaldson, NO Donohoe, O Donohoe, E Douka, T Doulias, M Downey, C Doyle, N Drye, DT Du, JG Dudek, PG Dunning, ARS Dyal, NJ Eardley, L Earnshaw, S Easdon, SE Edwards, RJ Egan, S El-Masry, O El-Tayar, CR Elbourne, S Elgaddal, M Elseedawy, M Elshaer, OH Elsharnoby, WMA Elzeneini, KM Emslie, NFT Engall, B Ertansel, HD Esmail, C Ettles, J Evans, JD Evans, A Everden, M Fadel, SE Fahmy, CJ Fairfield, BF Fanibi, Valeria Farina, SM Farrell, EZ Farrow, JA Fasuyi, G Faulkner, D Fawkner-Corbett, F Fawzi, M Fehervari, N Ferguson, JG Finch, H Finlayson, T Flack, W Foers, NM Foley, K Ford, A Forgie, A Foster, JD Foster, AMW Fox, N Francis, D Franklin, H Froud, HL Fuller, E Gaines, J Galea, E Gammeri, J Garnham, J Garvin, Z Gates, R Gentry, I Ghaffari, S Ghatorae, AL Gidwani, TG Gilbert, TM Gilbert, S Gill, M Gillespie, J Gillick, A Giorga, K Gopalakrishnan, S Gopalswamy, S Gopinath, R Gormely, G Govind, C Grant, J Graveston, J Gray, RT Gray, D Griffith, JP Griffith, Ewen A Griffiths, SN Griffiths, EJ Griggs, S Grosvenor, T Grove, M Gulamhussein, J Guliani, A Gummaraju, S Gunning, SV Gurjar, S Guru-Naidu, S Gurung, H Habib, L Hackney, James B Haddow, S Hajibandeh, C Halkias, NJ Hall, RN Hamelmann, M Haneef, MS Haneef, Z Hanif, C Hanley, AJ Hann, T Hanna, E Hardy, A Harlinska, F Harper, RL Harries, A Harris, Grant Harris, MP Harris, R Hasan, A Hassane, JR Hatt, Z Haveliwala, W Hawkins, Z Hayat, C Hayes, KRM Hebbar, L Henderson, LT Henderson, PJJ Herrod, P Hever, LM Hickey, G Hicks, JM Hodgson, M Hoff, A Hollingsworth, A Hook, ST Hornby, E Horsfield, EE Howie, L Huang, NJ Hudson-Peacock, DL Hughes, KA Hureibi, A Hussain, N Hussain, SA Hussaini, A Hussein, B Hutchinson, YMS Ibrahim, S Ikram, T Ilozue, E Iosif, MR Iqbal, S Irukulla, R Irwin, N Islam, P Ivey, CR Jackson, A Jackson, SMH Jah, A Jain, S Jain, Sarus Jain, GM Jama, NB Jamieson, S Janardanan, B Jasinski, D Jenner, E Jerome, B Johnson, A Johnstone, S Jokhan, A Jones, CE Jones, CS Jones, E Jones, L Jones, U Kabir, S Kabwama, M Kamal, IW Kamande, V Kanakala, M Kannegieser-Bailey, S Kaptanis, MJ Karim, RS Karwal, G Kaur, R Keegan, A Kelay, ND Kennedy, DA Kent, A Khair, K Khan, S Khan, A Khasria, H Kho, J Kilkenny, R King, J Kinross, EN Kirkham, B Knight, R Kochupapy, C Koh, O Kouli, A Krishnamoorthy, S Krivan, K Kumar, S Kumar, VWS Kung, R Kuo, G Lafaurie, CW Lai, N Lal, S Lawday, S Layman, GR Layton, A Lazzaro, L Lecky-Thompson, KA Lee, KJ Lee, M Lee, SL Lee, PA Leighton, RP Leitch, HC Lennox-Warburton, EL Leung, CH Li, JM Lim, C Limb, G Ljungqvist, G Lloyd, S Lodhia, PC Logan, M Long, P Long, RH Long, A Longshaw, C Louw, JN Lund, C Ly, MJ Lynch Wong, JKY Ma, A Macdonald, EGE Macinnes, T Magro, R Mahapatra, B Mahendran, F Mahmood, A Mahmoud, D Mahon, D Mai, A Maina, CP Major, R Makhija, Y Malam, A Malik, K Malik, SN Malik, VM Manda, KM Manektella, C Mann, P Manoharan, R Manson, S Mansoor, MM Mansour, S Mansour, F Maqboul, D Maragouthakis, G Marangoni, S Mardhiah, H Maripi, P Marriott, L Marsh, G Marshall, A Martin, LM Martin, E Martinou, R Mashar, John Mason, M Masood, G Mathew, K Maude, E Mazumdar, A 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AE Redmond, S Rekhraj, S Renshaw, D Rex, M Rezacova, S Rezvani, B Ribeiro, JE Rich, TD Richardson, S Rigby, B Rigney, S Rinkoff, HD Robb, C Robertson, D Robinson, A Robinson, V Rodger, R Rolph, S Roomi, NPG Roth, K Rothnie, C Roy, S Rupani, DG Rutherford, R Sacks, N Saghir, A Saha, SJ Sahay, K Sahnan, Y Salama, S Salim, M Samuel, S Sana, L Sandu, P Sarmah, J Sarveswaran, SMF Saunders, A Savill, F Savioli, JR Schuster Bruce, JF Sebastian, TC Seddon, N Seneviratne, M Seth, T Setshwaelo, E Sezen, P Sgardelis, A Sgrò, C Shah, J Shah, K Shah, SM Shah, Z Shakoor, MS Shalaby, V Shanmuganathan, K Shanmugarajah, A Sharma, P Sharma, OL Sharp, JA Shepherd, MA Sherif, S Shet, G Shingler, MH Shiwani, D Shreshta, T Sian, MN Siddiqui, ZA Siddiqui, KL Siggens, N Sihra, I Silva, A Simioni, LFC Simmonds, DJ Simpson, A Singh, S Singh, T Singhal, P Sivaloganathan, K Sloan, N Smallcombe, CJ Smart, Neil J Smart, R Smith, H Smoker, L Solinas, JEH Souter, EL Springate, GF Stephens, R Stevenson, DJ Stewart, I 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J., Smith, R., Smoker, H., Solinas, L., Souter, J. E. H., Springate, E. L., Stephens, G. F., Stevenson, R., Stewart, D. J., Stoica, I., Strachan, E., Stubbs, B. M., Stupalkowska, W., Suliman, A., Sultana, A., Sunter, H., Suriyakumar, S., Symons, N. R. A., Szentpali, K., Szucs, A., Tabain, V., Tague, L. E., Tailor, K., Tan, C. Y., Tan, S., Tang, A. M., Tarazi, M., Tay, Y. H., Tayeh, S., Taylor, M., Taylor, N. S., Taze, D., Teasdale, E., Thakral, N., Thava, B., Thavanesan, N., Thaventhiran, A. J., Theodoropoulou, K., Thomas, A. T., Thomas, L., Thompson, D. B., Thompson, R., Thoukididou, S. N., Tiboni, S. G., Tiedt, L. A., Ting, N., Tinsley, B. J., Tognarelli, J. M., Torkington, J., Torrance, A., Townsend, D. C., Tozer, P. J., Trail, M., Trew, F., Tudyka, V., Tullie, L., Turnbull, A., Turner, E. J., Twum-Barima, C. S., Tyler, R., Vakis, S., Valle, A. L., Van Boxel, G. I., Vance-Daniel, J., Varcada, M., Varma, N., Vaughan, E. M., Velchuru, V. R., Velho, R., Venkatasubramaniam, A. K., Venn, M. L., Vijay, V., Vinnicombe, Z., Vitish-Sharma, P., Wagener, S., Waite, K., Walters, K. J., Walters, U., Wardle, B. G., Wardle, S. D., Warusavitarne, J., Watfah, J., Watson, N., Wauchope, J., Weatherburn, L. W., Weegenaar, C. R., Welsh, S., Wheatstone, S., Whewell, H. E., Whitehouse, P., Whiteman, E., Whittaker, L., Wijesundera, K., Wilkinson, D., Williams, G. L., Williams, M., Williams, R., Williams, S., Wilson, E. J., Wilson, M. S. J., Winter, D. C., Winter, G., Wolff, J., Wong, A., Wong, C. L. L., Wong, S. Y., Wood, C. S., Woodrow, C., Woodward, A., Woodward, B., Wright, E., Wright, H. L., Wu, F., Yalamarthi, S., Yang, P., Yardimci, E., Yasin, T., Yen, S. K., Yoganathan, S., Yoong, S., Youssef, H., Yow, L. P. S., Zaborowski, A., Zadi, A. Z., Zarka, Z. A., Zarog, M. A., and Zhang, A. Y.
Subjects: Male, Pediatrics, medicine.medical_specialty, Validation study, Adolescent, Ultrasound scan, Pain, Risk prediction models, Risk Assessment, Sensitivity and Specificity, Cohort Studies, Ilium, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, 030225 pediatrics, Developmental and Educational Psychology, medicine, Appendectomy, Humans, Prospective Studies, 030212 general & internal medicine, Surgical emergency, Child, Ultrasonography, business.industry, Area under the curve, Appendicitis, medicine.disease, United Kingdom, Child, Preschool, Acute Disease, Pediatrics, Perinatology and Child Health, Female, Right iliac fossa pain, business, Ireland, Cohort study
Abstract: BACKGROUND: Acute appendicitis is the most common surgical emergency in children. Differentiation of acute appendicitis from conditions that do not require operative management can be challenging in children. This study aimed to identify the optimum risk prediction model to stratify acute appendicitis risk in children. METHODS: We did a rapid review to identify acute appendicitis risk prediction models. A prospective, multicentre cohort study was then done to evaluate performance of these models. Children (aged 5-15 years) presenting with acute right iliac fossa pain in the UK and Ireland were included. For each model, score cutoff thresholds were systematically varied to identify the best achievable specificity while maintaining a failure rate (ie, proportion of patients identified as low risk who had acute appendicitis) less than 5%. The normal appendicectomy rate was the proportion of resected appendixes found to be normal on histopathological examination. FINDINGS:15 risk prediction models were identified that could be assessed. The cohort study enrolled 1827 children from 139 centres, of whom 630 (34·5%) underwent appendicectomy. The normal appendicectomy rate was 15·9% (100 of 630 patients). The Shera score was the best performing model, with an area under the curve of 0·84 (95% CI 0·82-0·86). Applying score cutoffs of 3 points or lower for children aged 5-10 years and girls aged 11-15 years, and 2 points or lower for boys aged 11-15 years, the failure rate was 3·3% (95% CI 2·0-5·2; 18 of 539 patients), specificity was 44·3% (95% CI 41·4-47·2; 521 of 1176), and positive predictive value was 41·4% (38·5-44·4; 463 of 1118). Positive predictive value for the Shera score with a cutoff of 6 points or lower (72·6%, 67·4-77·4) was similar to that of ultrasound scan (75·0%, 65·3-83·1). INTERPRETATION: The Shera score has the potential to identify a large group of children at low risk of acute appendicitis who could be considered for early discharge. Risk scoring does not identify children who should proceed directly to surgery. Medium-risk and high-risk children should undergo routine preoperative ultrasound imaging by operators trained to assess for acute appendicitis, and MRI or low-dose CT if uncertainty remains. FUNDING: None.
Published: 2021

49. The ATLAS fast TracKer system

Author: Aad, Georges, Abbott, Braden Keim, Abreu, Henso, Arcangeletti, Chiara, Gutierrez Zagazeta, Luis Felipe, Gutschow, Christian, Guyot, Claude, Gwenlan, Claire, Gwilliam, Carl, Haaland, Even Simonsen, Haas, Andy, Haas, Andrew, Haber, Carl, Hadavand, Haleh, Arce, Ayana Tamu, Hadef, Asma, Haleem, Mahsana, Haley, Joseph, Hall, Jack Joseph, Halladjian, Garabed, Hallewell, Gregory, Hamano, Kenji, Hamdaoui, Hassane, Hamer, Matthias, Hamity, Guillermo Nicolas, Arguin, Jean-francois, Han, Kunlin, Han, Liangliang, Han, Liang, Han, Shuo, Han, Yi Fei, Hanagaki, Kazunori, Hance, Mike, Hank, Michael Donald, Hankache, Robert, Hansen, Eva Brottmann, Argyropoulos, Spyros, Hansen, Jorgen Beck, Hansen, Dines, Hansen, Maike Christina, Hansen, Peter, Hanson, Emily Claire, Hara, Kazuhiko, Harenberg, Torsten, Harkusha, Siarhei, Harrison, Paul Fraser, Hartman, Nicole Michelle, Arling, Jan-hendrik, Hartmann, Nikolai, Hasegawa, Yoji, Hasib, Ahmed, Hasley, Lloyd Alan, Hassani, Samira, Haug, Sigve, Hauser, Reiner, Havranek, Miroslav, Hawkes, Chris, Hawkings, Richard, Armbruster, Aaron James, Hayashida, Shota, Hayden, Daniel, Hayes, Christopher Robyn, Hayes, Robin, Hays, Chris, Hays, Jonathan, Hayward, Helen, Haywood, Stephen, He, Fudong, He, Yunjian, Armstrong, Alexander, Heath, Matthew Peter, Hedberg, Vincent, Heggelund, Andreas Lokken, Hehir, Natasha, Heidegger, Constantin, Heidegger, Kim Katrin, Heidorn, William Dale, Heilman, Jesse Alan, Heim, Sarah, Heim, Timon, Arnaez, Olivier, Heinemann, Beate, Heinlein, James Geddy, Heinrich, Jochen Jens, Heinrich, Lukas Alexander, Hejbal, Jiri, Helary, Louis, Held, Alexander, Hellesund, Simen, Helling, Cole Michael, Hellman, Sten, Arnold, Hannah, Helsens, Clement, Henderson, Robert, Henkelmann, Lars, Henriques Correia, Ana Maria, Herde, Hannah Elizabeth, Hernandez Jimenez, Yesenia, Herr, Holger Arnold, Herrmann, Maximilian Georg, Herrmann, Tim, Herten, Gregor, Arrubarrena Tame, Zulit Paola, Hertenberger, Ralf, Hervas, Luis, Hessey, Nigel, Hibi, Hiroaki, Higashino, Satoshi, Higon-rodriguez, Emilio, Hildebrand, Kevin, Hill, John, Hill, Kurt Keys, Hiller, Karl Heinz, Abulaiti, Yiming, Artoni, Giacomo, Hu, Yi Fan, Hiller, Karlheinz, Hillier, Stephen, Hils, Maximilian, Hinchliffe, Ian, Hinterkeuser, Florian, Hirose, Minoru, Hirose, Shigeki, Hirschbuehl, Dominic, Hiti, Bojan, Asada, Haruka, Hladik, Ondrej, Hobbs, John David, Hobincu, Radu, Tal Hod, Noam, Hodgkinson, Mark, Hoecker, Andreas, Hohn, David, Hohov, Dmytro, Holm, Tanja, Holmes, Tova, Asai, Kanae, Holzbock, Michael, Hommels, Bart, Hong, Tae Min, Honig, Jan Cedric, Honle, Andreas, Hooberman, Benjamin Henry, Hopkins, Walter, Horii, Yasuyuki, Horn, Philipp, Horyn, Lesya Anna, Asai, Shoji, Hou, Suen, Howarth, James William, Hoya, Joaquin, Hrabovsky, Miroslav, Hrynevich, Aliaksei, Hrynova, Tetiana, Hsu, Pai-hsien, Hsu, Shih-chieh, Hu, Qipeng, Hu, Shuyang, Asawatavonvanich, Thanawat, Iakovidis, Georgios, Hu, Yifan, Huang, Danping, Huang, Xiaozhong, Huang, Yicong, Huang, Yanping, Hubacek, Zdenek, Hubaut, Fabrice, Hubner, Michael, Huegging, Fabian, Asbah, Nedaa Alexandra, Huffman, Todd Brian, Huhtinen, Mika, Hulsken, Raphael, Hunter, Robert Francis, Husejko, Michal, Huseynov, Nazim, Huston, Joey, Huth, John, Hyneman, Rachel Jordan, Hyrych, Sofiia, Asimakopoulou, Eleni Myrto, Iacobucci, Giuseppe, Iakovidis, George, Ibragimov, Iskander, Iconomidou-fayard, Lydia, Iengo, Paolo, Ignazzi, Rosanna, Iguchi, Ryunosuke, Iizawa, Tomoya, Ikegami, Yoichi, Ilic, Nikolina, Asquith, Lily, Imam, Hajar, Introzzi, Gianluca, Iodice, Mauro, Iordanidou, Kalliopi, Ippolito, Valerio, Isacson, Max Fredrik, Ishino, Masaya, Islam, Wasikul, Issever, Cigdem, Istin, Serhat, Assahsah, Jihad, Ito, Hiroki, Iturbe, Julia, Iuppa, Roberto, Ivina, Anna, Izen, Joseph Michael, Izzo, Vincenzo, Jacka, Petr, Jackson, Paul, Jacobs, Ruth Magdalena, Jaeger, Benjamin Paul, Assamagan, Ketevi Adikle, Jakel, Gunnar, Jakobi, Katharina Bianca, Jakobs, Karl, Jakoubek, Tomas, Jamieson, Jonathan, Janas, Krzysztof, Jansky, Roland, Janus, Piotr Andrzej, Jarlskog, Goran, Jaspan, Adam Elliott, Acharya, Bobby Samir, Astalos, Robert, Javadov, Namig, Javurek, Tomas, Javurkova, Martina, Jeanneau, Fabien, Jeanty, Laura, Jejelava, Juansher, Jenni, Peter, Jezequel, Stephane, Jia, Jiangyong, Jia, Zihang, Atkin, Ryan Justin, Jiang, Yi, Jiggins, Stephen, Jimenez Morales, Fabricio Andres, Jimenez Pena, Javier, Jin, Shan, Jinaru, Adam, Jinnouchi, Osamu, Jivan, Harshna, Johansson, Per Daniel Conny, Johns, Kenneth, Atkinson, Markus Julian, Johnson, Christian, Jones, Eleanor, Jones, Roger, Jones, Samuel David, Jones, Tim, Joos, Markus, Jovicevic, Jelena, Ju, Xiangyang, Junggeburth, Johannes Josef, Juste Rozas, Aurelio, Atlay, Naim Bora, Kaczmarska, Anna, Kado, Marumi, Kagan, Harris, Kagan, Michael Aaron, Kahn, Alan Mathew, Kahra, Christian, Kaji, Toshiaki, Kajomovitz Must, Enrique, Kalderon, Charles William, Kartvelishvili, Vakhtang, Atmani, Hicham, Kalderon, Will, Kaluza, Adam, Kamenshchikov, Andrey, Kaneda, Michiru, Kang, Nathan Jihoon, Kang, Shuaiyan, Kano, Yuya, Kanzaki, Junichi, Kar, Deepak, Karava, Kla, Atmasiddha, Prachi, Kareem, Mohammad, Karkanias, Ioannis, Karpov, Sergey, Karpova, Zoya, Kaya, Fikriye Idil, Kartvelishvili, Vato, Karyukhin, Andrei, Kasimi, Eirini, Kastanas, Alex, Kasten, Michael Scott, Augsten, Kamil, Kato, Chikuma, Katzy, Judith, Kawade, Kentaro, Kawagoe, Kiyotomo, Kawaguchi, Tomomi, Kawaguchi, Yoshimasa, Kawamoto, Tatsuo, Kawamura, Gen, Kay, Ellis, Kaya, Colette, Austrup, Volker Andreas, Kazakos, Stergios, Kazanin, Vassili, Keaveney, James Michael, Keeler, Richard, Keller, John Stakely, Kelsey, Daniel Christopher, Kempster, Jacob Julian, Kendrick, James Andrew, Kennedy, Kiley Elizabeth, Kepka, Oldrich, Avolio, Giuseppe, Kersten, Susanne, Kersevan, Borut Paul, Ketabchi, Sana, Khalil-zada, Farhad, Khandoga, Mykola, Khanov, Alexander, Kharlamov, Alexey, Kharlamova, Tatyana, Khoda, Elham E, Khoo, Teng Jian, Ayoub, Mohamad Kassem, Khoriauli, Gia, Khramov, Evgeny, Khubua, Djemal, Kido, Shogo, Kiehn, Moritz, Kilgallon, Aaron Joseph, Kim, Eunchong, Kim, Young-kee, Kimura, Naoki, Kirchhoff, Andreas, Achkar, Baida, Azuelos, Georges, Kirchmeier, David, Kirk, Julie, Kiryunin, Andrei, Kishimoto, Tomoe, Kisliuk, Dylan Perry, Kitali, Vincent, Kitsaki, Chara, Kivernyk, Oleh, Klapdor-kleingrothaus, Thorwald, Klassen, Martin, Babal, Dominik, Klein, Christoph Thomas, Klein, Lucas, Klein, Matthew Henry, Klein, Max, Klein, Uta, Klimek, Pawel Jan, Klimentov, Alexei, Klimpel, Fabian, Klingl, Tobias, Klioutchnikova, Tatiana, Bachacou, Henri, Klitzner, Felix Fidelio, Kluit, Peter, Kluth, Stefan, Kneringer, Emmerich, Knoops, Edith, Knue, Andrea Helen, Kobayashi, Dai, Kobel, Michael, Kocian, Martin, Kodama, Takafumi, Bachas, Dinos, Kodys, Peter, Kock, Daniela, Konig, Philipp, Koffas, Thomas, Koehler, Nicolas, Kolb, Mathis, Koletsou, Iro, Komarek, Tomas, Koeneke, Karsten, Kong, Albert, Backman, Karl Filip, Kono, Takanori, Konstantinides, Vasilis, Konstantinidis, Nikolaos, Konya, Balazs, Kopeliansky, Revital, Koperny, Stefan Zenon, Korcyl, Krzysztof Marian, Kordas, Konstantinos, Kowalewski, Robert Victor, Kordas, Kostas, Bagnaia, Paolo, Koren, Guy, Korn, Andreas, Korolkov, Ilya, Korolkova, Elena, Korotkova, Natalia, Kortner, Oliver, Kortner, Sandra, Kostyukhin, Vadim, Kotsokechagia, Anastasia, Kotwal, Ashutosh, Bahrasemani, Sina, Koulouris, Aimilianos, Kourkoumeli-charalampidi, Athina, Kourkoumelis, Christine, Kourlitis, Evangelos, Kowalewski, Bob, Kozanecki, Witold, Kozhin, Anatoli, Kramarenko, Viktor, Kramberger, Gregor, Krasnopevtsev, Dimitrii, Bailey, Adam, Krasny, Mieczyslaw, Krasznahorkay, Attila, Kremer, Jakub, Kretzschmar, Jan, Kreul, Ken Matthias, Krieger, Peter, Krieter, Ferdinand, Krishnamurthy, Samyukta, Krishnan, Anjali, Krivos, Martin, Bailey, Virginia, Krizka, Karol, Kroeninger, Kevin Alexander, Kroha, Hubert, Kroll, Jiri, Kroll, Joe, Kulchitsky, Yuri, Kuleshov, Sergey, Kroll, Joseph Ira, Krowpman, Kyle Stuart, Kruchonak, Uladzimir, Baines, John, Krueger, Hans, Krumnack, Nils Erik, Kruse, Mark, Krzysiak, Janina Anna, Kubota, Arisa, Kuchinskaia, Olesia, Kuday, Sinan, Kuchler, Daniela, Kuechler, Jan, Kuehn, Susanne, Adam, Lennart, Bakalis, Christos, Kuhl, Thorsten, Kukhtin, Victor, Koultchitski, Yuri, Kuleshov, Serguei, Kulinich, Yakov Petrovich, Kumar, Mukesh, Kuna, Marine, Kupco, Alexander, Kupfer, Tobias, Kuprash, Oleg, Baker, Keith, Kurashige, Hisaya, Kurchaninov, Leonid, Kurochkin, Yurii, Kurova, Anastasia, Kurth, Matthew Glenn, Kuwertz, Emma Sian, Kuze, Masahiro, Kvam, Audrey Katherine, Kvita, Jiri, Kwan, Tony, Bakker, Pepijn Johannes, Lacasta Llacer, Carlos, Lacava, Francesco, Lack, David Philip John, Lacker, Heiko Markus, Lacour, Didier, Ladygin, Evgueni, Lafaye, Remi, Laforge, Bertrand, Lagouri, Theodota, Lai, Stanley, Bakos, Evelin, Lai, Stan, Lakomiec, Inga Katarzyna, Lambert, Joseph Earl, Lammers, Sabine Wedam, Lampl, Walter, Lampoudis, Christos, Lancon, Eric Christian, Landgraf, Ulrich, Landon, Murrough, Lang, Valerie, Bakshi Gupta, Debottam, Lange, Joern, Langenberg, Robert Johannes, Lankford, Andrew James, Lanni, Francesco, Lantzsch, Kerstin, Lanza, Agostino, Lapertosa, Alessandro, Laporte, Jean-francois, Lari, Tommaso, Lasagni Manghi, Federico, Balaji, Shyam, Lassnig, Mario, Latonova, Vera, Lau, Tak Shun, Laudrain, Antoine, Laurier, Alexandre, Lavorgna, Marco, Lawlor, Sean Dean, Lazzaroni, Massimo, Le, Brian, Le Guirriec, Emmanuel, Balasubramanian, Rahul, Lebedev, Alexandre, Leblanc, Matthew Edgar, LeCompte, Thomas, Leblanc, Matt, Le Compte, Tom, Ledroit, Fabienne, Lee, Ava Chloe Audrey, Lee, Claire, Lee, Graham Richard, Lee Jr, Lawrence, Baldin, Evgenii, Lee, Shih-chang, Lee, Songkyo, Lefebvre, Benoit, Lefebvre, Helena, Lefebvre, Michel, Leggett, Charles, Lehmann, Konstantin, Lehmann, Niklaus, Lehmann Miotto, Giovanna, Leight, William Axel, Balek, Petr, Leisos, Antonios, Lisboa Leite, Marco, Leitgeb, Clara Elisabeth, Leitner, Rupert, Leney, Katharine, Lenz, Tatjana, Leone, Sandra, Leonidopoulos, Christos, Leopold, Alexander, Leroy, Claude, Balli, Fabrice, Les, Robert, Lester, Christopher, Levchenko, Mikhail, Leveque, Jessica, Levin, Daniel, Levin, Dan, Levinson, Lorne, Lewis, Daniel James, Li, Boyang, Li, Bing, Adam Bourdarios, Claire, Balunas, William Keaton, Li, Changqiao, Li, Fan, Li, Heng, Li, Haifeng, Li, Jing, Li, Ke, Li, Liang, Li, Mengran, Li, Quanyin, Li, Shu, Balz, Johannes, Li, Xingguo, Li, Yichen, Li, Zhi, Li, Zhiying, Li, Zhelun, Li, Zhiyuan, Liang, Zhijun, Liberali, Valentino, Liberatore, Marianna, Liberti, Barbara, Banas, Elzbieta, Lie, Ki, Lim, Sanghoon, Lin, Chiao-ying, Lin, Kuan-yu, Linck, Rebecca, Lindley, Rachel Elizabeth, Lindon, Jack, Linss, Arthur, Lionti, Anthony, Lipeles, Elliot, Bandieramonte, Marilena, Lipniacka, Anna, Lisovyi, Mykhailo, Liss, Tony, Liss, Anthony Michael, Lister, Alison, Little, Jared, Liu, Bo, Liu, Bingxuan, Liu, Jianbei, Liu, Jesse, Bandyopadhyay, Anjishnu, Liu, Kun, Liu, Minghui, Liu, Mingyi, Liu, Peilian, Liu, Xiaotian, Liu, Yi, Liu, Yang, Liu, Yanlin, Liu, Yanwen, Livan, Michele, Barak, Liron, Lleres, Annick, Llorente Merino, Javier, Lloyd, Stephen, Lloyd, Steve, Lobodzinska, Ewelina Maria, Loch, Peter, Loffredo, Salvatore, Lohse, Thomas, Lohwasser, Kristin, Lokajicek, Milos, Barbe, William Mickael, Long, Jonathan, Long, Robin Eamonn, Longarini, Iacopo, Longo, Luigi, Longo, Riccardo, Lopez Paz, Ivan, Lopez Solis, Alvaro, Lorenz, Jeanette Miriam, Lorenzo Martinez, Narei, Lory, Alexander, Barberio, Elisabetta, Loesle, Alena, Lou, Xuanhong, Lou, Xinchou, Lounis, Abdenour, Love, Jeremy Robert, Love, Peter, Lozano Bahilo, Julio, Lu, Miaoran, Lu, Sicong, Lu, Yun-ju, Barberis, Dario, Lubatti, Henry, Luci, Claudio, Lucio Alves, Fabio Lucio, Lucotte, Arnaud, Luehring, Fred, Luise, Ilaria, Luminari, Lamberto, Lund-jensen, Bengt, Luongo, Nicholas, Lutz, Margaret Susan, Barbero, Marlon Benoit, Lynn, David, Lyons, Harry John, Lysak, Roman, Lytken, Else, Lyu, Feng, Lyubushkin, Vladimir, Lyubushkina, Tatiana, Ma, Hong, Ma, Lianliang, Ma, Yanhui, Adamczyk, Leszek, Barbour, Gregory, Macdonell, Danika Marina, Maccarrone, Giovanni, Macdonald, Calum Michael, Macdonald, Jack, Machado Miguens, Joana, Madar, Romain, Mader, Wolfgang, Madugoda Ralalage Don, Madhuranga, Madysa, Nico, Maeda, Junpei, Barillari, Teresa, Maeno, Tadashi, Maerker, Max, Magerl, Veronika, Magro, Jacopo, Mahon, Devin, Maidantchik, Carmen, Maio, Amelia, Maj, Klaudia, Majersky, Oliver, Majewski, Stephanie, Barisits, Martin, Makovec, Nikola, Malaescu, Bogdan, Malecki, Pawel, Maleev, Victor, Malek, Fairouz, Malito, Davide, Mallik, Usha, Malone, Claire, Maltezos, Stavros, Malyukov, Sergey, Barkeloo, Jason Tyler Colt, Mamuzic, Judita, Mancini, Giada, Mandalia, Jesal, Mandic, Igor, Manhaes De Andrade Filho, Luciano, Maniatis, Ioannis Michail, Manjarres, Joany, Mankinen, Katja Hannele, Mann, Alexander, Manousos, Athanasios, Barklow, Tim, McCarthy, Tom, McDonald, Emily, Manousos, Thanos, Mansoulie, Bruno, Manthos, Ioannis, Manzoni, Stefano, Marantis, Alexandros, Marchese, Luigi, Marchiori, Giovanni, Marcisovsky, Michal, Barnett, Bruce M, Marcoccia, Lorenzo, Marcon, Caterina, Marjanovic, Marija, Marshall, Zach, Martensson, Mikael, Marti I Garcia, Salvador, Martin, Tim, Martin, Victoria, Martin Dit Latour, Bertrand, Martinelli, Luca, Barnett, Michael, Martinez-perez, Mario, Martinez Agullo, Pablo, Martinez Outschoorn, Verena Ingrid, Martin-haugh, Stewart, Martoiu, Sorin, Martyniuk, Alex Christopher, Marzin, Antoine, Maschek, Stefan Raimund, Masetti, Lucia, Mashimo, Tetsuro, Blenessy, Zuzana, Mashinistov, Ruslan, Masik, Jiri, Maslennikov, Alexei, Massa, Lorenzo, Massarotti, Paolo, Mastrandrea, Paolo, Mastroberardino, Anna, Masubuchi, Tatsuya, Matakias, Dimitrios, Mathisen, Thomas, Baroncelli, Toni, Matic, Andrea, Matsuzawa, Nobuo, Maurer, Julien, Macek, Bostjan, Maximov, Dmitriy, Mazini, Rachid, Maznas, Ioannis, Mazza, Simone Michele, Mc Ginn, Christopher, Mc Gowan, John Patrick, Barone, Gaetano, Mc Kee, Shawn, Mcfayden, Joshua Angus, McPherson, Robert, Mikenberg, Giora, Mccarthy, Thomas, Mccormack, William Patrick, Milke, Christopher Don, Mina, Robert Arthur, Mcdonald, Millie, Mcdougall, Ashley Ellen, Adamek, Lukas, Barr, Alan, Mcfayden, Josh, Mchedlidze, Gvantsa, Mc Kay, Maddie, Mclean, Kayla, Mcmahon, Stephen, Mcnamara, Peter Charles, Mcnicol, Christopher John, Mcpherson, Rob, Mdhluli, Joyful Elma, Meadows, Zachary Alden, Barranco Navarro, Laura, Meehan, Samuel Ross, Megy, Theo, Mehlhase, Sascha, Mehta, Andrew, Meirose, Bernhard, Melini, Davide, Mellado Garcia, Bruce, Meloni, Federico, Melzer, Alexander, Gouveia, Emanuel, Barreiro Alonso, Fernando, Mendes Jacques Da Costa, Antonio Manuel, Meng, Huan Yu, Meng, Lingxin, Menke, Sven, Meoni, Evelin, Mergelmeyer, Sebastian, Merkt, Sebastian Andreas, Merlassino, Claudia, Mermod, Philippe, Merola, Leonardo, Barreiro Guimaraes Da Costa, Joao, Meroni, Chiara, Merz, Garrett William, Meshkov, Oleg, Meshreki, John Kamal Rizk, Metcalfe, Jessica, Mete, Alaettin Serhan, Meyer, Christopher John, Meyer, Jean-pierre, Michetti, Michele, Middleton, Robin, Barron, Uriel, Mijovic, Liza, Mikenberg, George, Mikestikova, Marcela, Mikuz, Marko, Mildner, Hannes, Milic, Adriana, Milke, Chris, Miller, David, Miller, Laura Stephanie, Milov, Alexander, Barsov, Sergey, Milstead, David Anthony, Mina, Rob, Minaenko, Andrei, Minashvili, Irakli, Mince, Laurynas, Mincer, Allen Irving, Mindur, Bartosz, Mineev, Mikhail, Minegishi, Yuji, Mino, Yuya, Bartels, Falk, Mir Martinez, Lluisa Maria, Mironova, Maria, Mitani, Takashi, Mitrevski, Jovan, Mitsou, Vasiliki, Mittal, Monika, Miu, Ovidiu, Miucci, Antonio, Miyagawa, Paul, Mizukami, Atsushi, Bartoldus, Rainer, Mjoernmark, Jan-ulf, Mkrtchyan, Tigran, Mlynarikova, Michaela, Moa, Torbjorn, Mobius, Silke, Mochizuki, Kazuya, Moder, Paul, Mogg, Philipp, Mohapatra, Soumya, Mokgatitswane, Gaogalalwe, Bartolini, Giovanni, Momiyama, Keisuke, Mondal, Buddhadeb, Mondal, Santu, Monig, Klaus, Monnier, Emmanuel, Montalbano, Alyssa Rae, Montejo Berlingen, Javier, Montella, Marco, Monticelli, Fernando, Morange, Nicolas, Barton, Adam Edward, Moreira De Carvalho, Ana Luisa, Moreno Llacer, Maria, Moreno Martinez, Carlos, Morettini, Paolo, Morgenstern, Marcus Matthias, Morgenstern, Stefanie, Mori, Daniel, Morii, Masahiro, Morinaga, Masahiro, Morisbak, Vanja, Adelman, Jahred, Bartos, Pavol, Morley, Anthony, Mornacchi, Giuseppe, Morris, Alice, Morvaj, Ljiljana, Moschovakos, Paraschos, Moss, Josh, Nachman, Benjamin Philip, Moschovakos, Paris, Moser, Brian, Mosidze, Maia, Basalaev, Artem, Moskalets, Tetiana, Moskvitina, Polina, Naryshkin, Iouri, Moss, Joshua, Moyse, Edward, Muanza, Steve, Mueller, James Alfred, Muenstermann, Daniel, Mullier, Geoffrey, Mullin, Joseph, Basan, Alexander, Mungo, Davide Pietro, Munoz Martinez, Jose Luis, Munoz Sanchez, Francisca, Murin, Pavel, Murray, Bill, Murrone, Alessia, Muse, Joseph M, Muskinja, Miha, Mwewa, Chilufya, Myagkov, Alexei, Bassalat, Ahmed, Myers, Ava Anne, Myers, Greg, Myers, John, Myska, Miroslav, Neep, Thomas James, Ng, Yan Wing, Nachman, Ben, Nackenhorst, Olaf, Nag, Abhishek, Nagai, Koichi, Basso, Matthew Joseph, Nagano, Kunihiro, Nagle, James Lawrence, Nagy, Elemer, Nairz, Armin, Higuchi, Yu Nakahama, Nakamura, Koji, Nanjo, Hajime, Napolitano, Fabrizio, Naranjo, Roger, Narayan, Rohin Thampilali, Basson, Candice Ruth, Naryshkin, Iurii, Naseri, Mohsen, Naumann, Thomas, Navarro, Gabriela Alejandra, Navarro Gonzalez, Josep, Nechaeva, Polina, Nechansky, Filip, Neep, Tom, Negri, Andrea, Negrini, Matteo, Bates, Richard, Nellist, Clara, Nelson, Christina, Nelson, Michael Edward, Nemecek, Stanislav, Nessi, Marzio, Neubauer, Mark, Neuhaus, Friedemann, Neumann, Manuel, Newhouse, Robin, Newman, Paul Richard, Batlamous, Souad, Ng, Chi Wing, Ng, Sam Yanwing, Ng, Ying Wun Yvonne, Ngair, Badr-eddine, Nguyen, Hoang Dai Nghia, Nguyen Manh, Tuan, Nibigira, Emery, Nickerson, Richard, Nikolaidou, Rosy, Nielsen, Daniel, Batley, Richard, 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Giuseppe, Schaffer, Arthur, Schegelsky, Valery, Benoit, Mathieu, Salnikov, Andy, Salt, Jose, Salvador Salas, Adrian, Salvatore, Daniela, Salvatore, Fabrizio, Salzburger, Andreas, Sammel, Dirk, Sampsonidis, Dimos, Sampsonidou, Despoina, Sanchez Martinez, Francisco Javier, Bensinger, Jim, Sanchez Pineda, Arturos, Sandaker, Heidi, Sander, Christian, Sanderswood, Izaac, Sandhoff, Marisa, Sandoval Usme, Carlos, Sankey, David, Sannino, Mario, Sano, Yuta, Sansoni, Andrea, Bentvelsen, Stan, Santoni, Claudio, Santos, Helena, Santpur, Sai Neha, Santra, Arka, Saoucha, Kamal, Sapronov, Andrey, Mendes Saraiva, Joao Gentil, Sasaki, Osamu, Sato, Koji, Sauerburger, Frank, Beresford, Lydia Audrey, Sauvan, Emmanuel, Savard, Pierre, Sawada, Ryu, Sawyer, Craig Anthony, Sawyer, Lee, Sayago Galvan, Ivan, Sbarra, Carla, Sbrizzi, Antonio, Scanlon, Timothy Paul, Schaarschmidt, Jana, Afik, Yoav, Beretta, Matteo Mario, Schacht, Peter, Schaefer, Douglas Michael, Schaefer, Leigh Catherine, Schaefer, Uli, Schaffer, R. 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M. S., Sultanov, Salekh, Sumida, Toshi, Sun, Siyuan, Sun, Xiaohu, Suster, Carl Joseph Edmund, Sutton, Mark, Svatos, Michal, Swiatlowski, Maximilian J, Swift, Stewart Patrick, Biebel, Otmar, Swirski, Thorben, Sydorenko, Alexander, Sykora, Ivan, Sykora, Martin, Sykora, Tomas, Ta, Duc Bao, Tackmann, Kerstin, Kinghorn-taenzer, Joseph Peter, Taffard, Anyes, Tafirout, Reda, Biedermann, Dustin, Tagiev, Emin, Taibah, Reem Hani M, Takashima, Ryuichi, Takeda, Kosuke, Takeshita, Toru, Takeva, Emily Petrova, Takubo, Yosuke, Talby, Mossadek, Talyshev, Alexei, Tam, Kai Chung, Bielski, Rafal, Tamir, Nadav Michael, Tanaka, Junichi, Tanaka, Reisaburo, Tokar, Stanislav, Tsukerman, Ilya, Tsybychev, Dmitri, Tuts, Michael, Vacek, Vaclav, Tanaka, Rei, Tang, Fukun, Bierwagen, Katharina, Tapia Araya, Sebastian, Tapprogge, Stefan, Tarek, Ahmed, Tarem, Shlomit, Tariq, Khuram, Tarna, Grigore, Vandewall, Evan Richard, Vermeulen, Jos, Tartarelli, Francesco, Tas, Petr, Biesuz, Nicolo Vladi, Tasevsky, Marek, Tassi, 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Thomas, Whalen, Kate, Wharton, Andrew Mark, White, Aaron Stephen, White, Andrew, White, Martin John, Whiteson, Daniel, Whitmore, Ben, Bogdan, Mircea Arghir, Wiedenmann, Werner, Wiel, Christian, Wielers, Monika, Wieseotte, Natalie, Wiglesworth, Craig, Wiik-fuchs, Liv, Wilkens, Henric, Wilkins, Lewis, Williams, Daniel, Williams, Hugh, Bogdanchikov, Alexander, Williams, Sarah Louise, Willocq, Stephane, Windischhofer, Philipp, Wingerter, Isabelle, Winkels, Emma, Winklmeier, Frank, Winter, Benedict Tobias, Wittgen, Matthias, Wobisch, Markus, Wolf, Anton, Bohm, Christian, Woelker, Ricardo, Wollrath, Julian, Wolter, Marcin, Wolters, Helmut, Wong, Vincent Wai Sum, Wongel, Alicia, Woods, Natasha Lee, Worm, Steven, Wosiek, Barbara Krystyna, Wozniak, Krzysztof Wieslaw, Boisvert, Veronique, Wraight, Kenneth Gibb, Wu, Sau Lan, Wu, Xin, Wu, Yusheng, Wurzinger, Jonas, Wyatt, Terry, Wynne, Benjamin Michael, Xella, Stefania, Xiang, Jianhuan, Xiao, Xiong, Bokan, Petar, Xie, Xiangyu, Xiotidis, Ioannis, Xu, Da, Xu, Hanlin, Xu, Hao, Xu, Lailin, Xu, Riley, Xu, Tairan, Zaitsev, Alexander, Zeng, Jian Cong, Bold, Tomasz, Zhu, Cheng Guang, Xu, Wenhao, Xu, Yue, Xu, Zhongyukun, Xu, Zijun, Yabsley, Bruce Donald, Yacoob, Sahal, Yallup, David, Yamaguchi, Naoki, Yamaguchi, Yohei, Ahmad, Ammara, Bomben, Marco, Yamatani, Masahiro, Yamauchi, Hiroki, Yamazaki, Tomohiro, Yamazaki, Yuji, Yan, Jun, Yan, Zhen, Yang, Haijun, Yang, Hongtao, Yang, Siqi, Yang, Tianyi, Bona, Marcella, Yang, Xiao, Yang, Xuan, Yang, Yi-lin, Yang, Zhe, Yao, Weiming, Young, Charles, Zacharis, George, Yao, Wei-ming, Yap, Yee Chinn, Ye, Hanfei, Bonilla, Johan Sebastian, Ye, Jingbo, Ye, Shuwei, Yeletskikh, Ivan, Yexley, Melissa, Yin, Pengqi, Yorita, Kohei, Yoshihara, Keisuke, Young, Christopher, Young, Charlie, Yuan, Rui, Boonekamp, Maarten, Yue, Xiaoguang, Zaazoua, Mohamed, Zabinski, Bartlomiej Henryk, Zacharis, Georgios, Zaffaroni, Ettore, Zahreddine, Jad, Zaytsev, Alexandre, Zakareishvili, Tamar, Zakharchuk, Nataliia, Zambito, Stefano, Booth, Callum Dale, Zanzi, Daniele, Zeissner, Sonja Verena, Zeitnitz, Christian, Zemaityte, Gabija, Zeng, Jiancong, Zenin, Oleg, Zenis, Tibor, Zenz, Seth, Zerradi, Soufiane, Zerwas, Dirk, Borbely, Albert Gyorgy, Zgubic, Miha, Zhang, Bowen, Zhang, Dengfeng, Zhang, Gang, Zhang, Jinlong, Zhang, Kaili, Zhang, Lei, Zhang, Liqing, Zhang, Matt, Zhang, Rui, Borecka-bielska, Hanna Maria, Zhang, Shuzhou, Zhang, Xiangke, Zhang, Xueyao, Zhang, Yu, Zhang, Zhiqing Philippe, Zhao, Pingchuan, Zhao, Yuzhan, Zhao, Zhengguo, Zhemchugov, Alexey, Zheng, Zhi, Borgna, Lucas Santiago, Zhong, Dewen, Zhou, Bing, Zhou, Chen, Zhou, Hao, Zhou, Mingliang, Zhou, Ning, Zhou, You, Zhu, Chengguang, Zhu, Chenzheng, Zhu, Heling, Borisov, Anatoli, Zhu, Hongbo, Zhu, Junjie, Zhu, Yingchun, Zhuang, Xuai, Zhukov, Konstantin, Zhulanov, Vladimir, Zieminska, Daria, Zimine, Nikolai, Zimmermann, Stephanie Ulrike, Zinonos, Zinonas, Borissov, Guennadi, Ziolkowski, Michal, Zivkovic, Lidija, Zoccoli, Antonio, Zoch, Knut, Zorbas, Theodore, Zou, Rui, Zwalinski, Lukasz, ATLAS Collaboration, Abed Abud, Adam, Ahmadov, Faig, Bortoletto, Daniela, Boscherini, Davide, Fernandez-bosman, Martine, Bossio, Jonathan, Bouaouda, Khalil, Boudreau, Joseph, Bouhova-thacker, Eva, Boumediene, Djamel Eddine, Bouquet, Romain, Bourlis, Georgios, Ahmed, Waleed Syed, Boveia, Antonio, Boyd, Jamie, Boye, Diallo, Boyko, Igor, Bozson, Adam, Bracinik, Juraj, Brahimi, Nihal, Brandt, Gerhard Immanuel, Brandt, Oleg, Braren, Frued Erik, Ai, Xiaocong, Brau, Benjamin Paul, Brau, Jim, Breaden Madden, Will, Brendlinger, Kurt, Schimmel Brener, Roy, Brenner, Lydia, Brenner, Richard, Bressler, Shikma, Brickwedde, Bernard, Briglin, Daniel Lawrence, Aielli, Giulio, Britton, David, Britzger, Daniel Andreas, Brock, Ian, Brock, Raymond, Brooijmans, Gustaaf, Brooks, William King, Brost, Elizabeth, Bruckman De Renstrom, Pawel, Bruers, Ben, Bruncko, Dusan, Akatsuka, Shunichi, Bruni, Alessia, Bruni, Graziano, Bruschi, Marco, Bruscino, Nello, Bryant, Patrick Eugene, Bryngemark, Lene Kristian, Buanes, Trygve, Buat, Quentin, Buchholz, Peter, Buckley, Andy, Akbiyik, Melike, Budagov, Ioulian, Bugge, Magnar Kopangen, Bulekov, Oleg, Bullard, Brendon, Burch, Tyler James, Burdin, Sergey, Burgard, Carsten Daniel, Burger, Angela Maria, Burghgrave, Blake Oliver, Burr, Jon, Akesson, Torsten, Burton, Charles, Burzynski, Jackson Carl, Buescher, Volker, Buschmann, Eric, Bussey, Peter John, Butler, John Mark, Buttar, Craig, Butterworth, Jonathan, Buzykaev, Aleksey, Buttinger, Will, Akilli, Ece, Buxo Vazquez, Carlos Josue, Buzykaev, Alexey, Cabras, Grazia, Cabrera Urban, Susana, Caforio, Davide, Cai, Huacheng, Cairo, Valentina, Cakir, Orhan, Calace, Noemi, Calafiura, Paolo, Akimov, Andrei, Calderini, Giovanni, Calfayan, Philippe, Callea, Giuseppe, Caloba, Luiz, Caltabiano, Alessandro, Calvente Lopez, Sergio, Calvet, David, Calvet, Samuel, Calvet, Thomas Philippe, Calvetti, Milene, Al Khoury, Konie, Camacho Toro, Reina Coromoto, Camarda, Stefano, Camarero Munoz, Daniel, Camarri, Paolo, Camerlingo, Maria Teresa, Cameron, David, Camincher, Clement, Campana, Simone, Campanelli, Mario, Camplani, Alessandra, Abeling, Kira, Alberghi, Gian Luigi, Canale, Vincenzo, Canesse, Auriane, Bret Cano, Marc, Cantero Garcia, Josu, Cao, Yumeng, Capua, Marcella, Cardarelli, Roberto, Cardillo, Fabio, Carducci, Giovandomenico, Carli, Tancredi, Albert, Justin, Carlino, Giampaolo, Carlson, Ben, Carlson, Evan Michael, Carminati, Leonardo, Carney, Rebecca, Caron, Sascha, Carquin Lopez, Edson, Carra, Sonia, Carratta, Giuseppe, Carter, Joseph, Albicocco, Pietro, Carter, Thomas Michael, Casado Lechuga, Pilar, Casha, Albert Francis, Castiglia, Emma Grace, Castillo, Florencia Luciana, Castillo Garcia, Lucia, Castillo Gimenez, Victoria, Castro, Nuno, Catinaccio, Andrea, Catmore, James, Alconada, Josefina, Cattai, Ariella, Cavaliere, Viviana, Cavasinni, Vincenzo, Celebi, Emre, Celli, Federico, Cerny, Karel, Santiago Cerqueira, Augusto, Cerri, Alex, Cerrito, Lucio, Cerutti, Fabio, Alderweireldt, Sara, Cervelli, Alberto, Cetin, Serkant, Chadi, Zakaria, Chakraborty, Dhiman, Chan, Jay, Chan, Terry Ws, Chan, Wai Yuen, Chapman, John Derek, Chargeishvili, Bakar, Charlton, Dave, Aleksa, Martin, Charman, Thomas Paul, Chatterjee, Meghranjana, Chau, Chav Chhiv, Chekanov, Sergei, Chekulaev, Sergey, Shelkov, G., Chen, Boping, Chen, Cheng, Chen, Chunhui, Chen, Huirun, Alexandrov, Igor, Chen, Hucheng, Chen, Jing, Chen, Jue, Chen, Jiayi, Chen, Shion, Chen, Shenjian, Chen, Xin, Chen, Ye, Chen, Yu-heng, Cheng, Hok Chuen, Alexa, Calin, Cheng, Huajie, Cheplakov, Alexander, Cheremushkina, Evgeniya, Cherkaoui El Moursli, Rajaa, Cheu, Elliott, Cheung, Kingman, Chevalerias, Thibault, Chevalier, Laurent, Chiarella, Vitaliano, Chiarelli, Giorgio, Alexopoulos, Theodoros, Chiodini, Gabriele, Chisholm, Andrew Stephen, Chitan, Adrian, Chiu, I-huan, Chiu, Justin, Chizhov, Mihail, Choi, Kyungeon, Chomont, Arthur, Chou, Yuan-tang, Chow, Edwin, Alfonsi, Alice, Christopher, Lawrence Davou, Chu, Ming Chung, Chu, Xiaotong, Chudoba, Jiri, Chwastowski, Janusz, Cieri, Davide, Ciesla, Krzysztof, Cindro, Vladimir, Cioara, Irina Antonela, Ciocio, Alessandra, Abhayasinghe, Deshan Kavishka, Alfonsi, Fabrizio, Cirotto, Francesco, Citraro, Saverio, Citron, Zvi, Citterio, Mauro, Ciubotaru, Dan Andrei, Ciungu, Bianca Monica, Clark, Allan, Clark, Philip, Clawson, Savannah, Clement, Christophe, Alhroob, Muhammad, Clissa, Luca, Coadou, Yann, Cobal, Marina, Coccaro, Andrea, Cochran Jr, James Herbert, Coelho Lopes De Sa, Rafael, Cohen, Hadar, Coimbra, Artur, Cole, Brian, Colijn, Auke-pieter, Ali, Babar, Collot, Johann, Conde Muino, Patricia, Connell, Simon, Connelly, Ian Allan, Conventi, Francesco, Sarkar, Amanda, Cormier, Felix, Corpe, Louie Dartmoor, Corradi, Massimo, Corrigan, Eric Edward, Ali, Shahzad, Corriveau, Francois, Costa Mezquita, Maria Jose, Costanza, Francesco, Costanzo, Davide, Cowan, Glen, Cowley, James William, Crane, Jonathan, Cranmer, Kyle Stuart, Creager, Rachael Ann, Crepe-renaudin, Sabine, Aliev, Malik, Crescioli, Francesco, Cristinziani, Markus, Cristoforetti, Marco, Croft, Vincent Alexander, Crone, Gordon, Crosetti, Giovanni, Cunningham, William Reilly, Crosetti, Nanni, Cueto Gomez, Ana Rosario, Cuhadar Donszelmann, Tulay, Alimonti, Gianluca, Cui, Han, Cukierman, Aviv Ruben, Dandoy, Jeffrey Rogers, Darbo, Giovanni, Cunningham, Liam, Czekierda, Sabina Anna, Czodrowski, Patrick Karl, Czurylo, Marta, Sousa, Mario Jose, Da Fonseca Pinto, Joao Victor, Alison, John, Da Via, Cinzia, Dabrowski, Wladyslaw, Dachs, Florian, Dado, Tomas, Dahbi, Salah-eddine, Dai, Tiesheng, Dallapiccola, Carlo, Dam, Mogens, D'amen, Gabriele, D'amico, Valerio, Allaire, Corentin, Damp, Johannes Frederic, Dandoy, Jeff, Daneri, Maria Florencia, Danninger, Matthias, Dao, Valerio, Darbo, Nanni, Dartsi, Olympia, Dattagupta, Aparajita, D'auria, Saverio, David, Claire, Allbrooke, Benedict, Davidek, Tomas, Davis, Douglas Raymond, Dawson, Ian, De, Kaushik, De Asmundis, Riccardo, De Beurs, Marcus, De Castro, Stefano, De Groot, Nicolo, Vicente, Marcelo, De Jong, Paul, Allport, Philip Patrick, De La Torre Perez, Hector, De Maria, Antonio, De Pedis, Daniele, De Salvo, Alessandro, De Sanctis, Umberto, De Santis, Maurizio, De Santo, Antonella, De Vivie De Regie, Jean-baptiste, Dedovich, Dmitri, Deiana, Allison Mccarn, Abidi, Haider, Aloisio, Alberto, Del Peso, Jose, Delabat Diaz, Yasiel, Delgove, David, Deliot, Frederic, Delitzsch, Chris Malena, Della Pietra, Massimo, Della Volpe, Domenico, Dell'acqua, Andrea, Dell'asta, Lidia, Delmastro, Marco, Alonso, Francisco, Delporte, Charles Eliaz, Delsart, Pierre Antoine, Demers Konezny, Sarah Marie, Demichev, Mikhail, Demontigny, Gabriel, Denisov, Sergey, Denisov, Serguei, D'eramo, Louis, Derendarz, Dominik Karol, Derkaoui, Jamal, Alpigiani, Cristiano, Derue, Frederic, Dervan, Paul, Desch, Klaus, Dette, Karola, Deutsch, Christopher, Deviveiros, Pier-olivier, Di Bello, Francesco Armando, Di Ciaccio, Anna, Di Ciaccio, Lucia, Di Donato, Camilla, Alunno Camelia, Elio, Di Girolamo, Alessandro, Di Gregorio, Giulia, Di Luca, Andrea, Di Micco, Biagio, Di Nardo, Roberto, Di Sipio, Riccardo, Diaconu, Cristinel, De Almeida Dias, Flavia, Vale, Tiago, Diaz Gutierrez, Marco Aurelio, Alvarez Estevez, Manuel, Diaz Capriles, Federico Guillermo, Dickinson, Jennet Elizabeth, Didenko, Mariia, Diehl, Edward, Dietrich, Janet, Diez Cornell, Sergio, Diez Pardos, Carmen, Dimitrievska, Aleksandra, Ding, Wei, Dingfelder, Jochen Christian, Alviggi, Mariagrazia, Dittmeier, Sebastian, Dittus, Fido, Djama, Fares, Djobava, Tamar, Djuvsland, Julia Isabell, Barros do Vale, Maria Aline, Dobre, Monica, Dodsworth, David Michael, Doglioni, Caterina, Dolejsi, Jiri, Do Amaral Coutinho, Yara, Dolezal, Zdenek, Donadelli, Marisilvia, Dong, Binbin, Donini, Julien Noce, D'onofrio, Adelina, D'onofrio, Monica, Dopke, Jens, Doria, Alessandra, Dova, Maria Teresa, Doyle, Tony, Ambler, Alessandro, Drake, Gary, Drechsler, Eric, Dreyer, Etienne, Dreyer, Timo, Drobac, Alec Swenson, Du, Dongshuo, Du Pree, Tristan Arnoldus, Duan, Yanyun, Dubinin, Filipp, Dubovsky, Michal, Ambroz, Luca, Dubreuil, Arnaud, Duchovni, Ehud, Duckeck, Guenter, Ducu, Otilia Anamaria, Duda, Dominik, Dudarev, Alexey, Dudder, Andreas Christian, D'uffizi, Matteo, Duflot, Laurent, Duehrssen-debling, Michael, Amelung, Christoph, Dulsen, Carsten, Dumancic, Mirta, Dumitriu, Ana Elena, Dunford, Monica, Dungs, Sascha, Duperrin, Arnaud, Yildiz, Duran, Dueren, Michael Johannes, Durglishvili, Archil, Dutta, Baishali, Abouzeid, Hass, Amidei, Dante, Duvnjak, Damir, Dyckes, George, Ellis, Nicolas, Dyckes, Ian, Dyndal, Mateusz, Dysch, Samuel Dezso, Dziedzic, Bartosz Sebastian, Eggleston, Michael Glenn, Eifert, Till, Eigen, Gerald, Amor Dos Santos, Susana Patricia, Einsweiler, Kevin Frank, Ekelof, Tord Johan Carl, El Jarrari, Hassnae, Ellajosyula, Venugopal, Ellert, Mattias, Ellinghaus, Frank, Elliot, Alison, Ellis, Nick, Emerman, Alexander, Elmsheuser, Johannes, Amoroso, Simone, Elsing, Markus, Emeliyanov, Dmitry, Ezhilov, Alexey, Emerman, Alex, Enari, Yuji, Erdmann, Johannes, Ereditato, Antonio, Erland, Paula Agnieszka, Errenst, Martin, Escalier, Marc, Amrouche, Cherifa Sabrina, Escobar Ibanez, Carlos, Estrada Pastor, Oscar, Etzion, Erez, Gaspar De Andrade Evans, Guiomar, Evans, Hal, Evans, Meirin Oan, Ezhilov, Aleksei, Fabbri, Federica, Fabbri, Laura, Fabiani, Veronica, Anastopoulos, Christos, Facini, Gabriel, Fakhrutdinov, Rinat, Falciano, Speranza, Falke, Peter Johannes, Falke, Saskia, Faltova, Jana, Fang, Yi, Fang, Yaquan, Fanourakis, Georgios, Fanti, Marcello, Andari, Nansi, Faraj, Mohammed, Farbin, Amir, Farilla, Addolorata, Farilla, Ada, Farina, Edoardo Maria, Farooque, Trisha, Farrington, Sinead, Farthouat, Philippe, Fassi, Farida, Fassnacht, Patrick, Andeen, Timothy Robert, Fassouliotis, Dimitris, Faucci Giannelli, Michele, Fawcett, William James, Fayard, Louis, Fedin, Oleg, Fehr, Armin, Feickert, Matthew Carl, Feligioni, Lorenzo, Fell, Alix, Fell, Alexandra, Anders, John Kenneth, Feng, Cunfeng, Feng, Minyu, Fenton, Michael James, Fenyuk, Alexandre, Ferguson, Sarah Whitney, Ferrando, James Edward, Ferrari, Arnaud, Ferrari, Pamela, Ferrari, Roberto, Ferrer Soria, Antonio, Anderson, John Thomas, Ferrere, Didier, Ferretti, Claudio, Fiedler, Frank, Filipcic, Andrej, Filthaut, Frank, Finelli, Kevin Daniel, Castro Nunes Fiolhais, Miguel, Fiorini, Luca, Fischer, Florian, Fischer, Julian, Andrean, Stefio Yosse, Fisher, Wade Cameron, Fitschen, Tobias, Fleck, Ivor, Fleischmann, Philipp, Flick, Tobias, Flierl, Bernhard Matthias, Flores, Lucas Macrorie, Flores Castillo, Luis Roberto, Follega, Francesco Maria, Fomin, Nikolai, Abraham, Nicola Louise, Andreazza, Attilio, Foo, Joel Hengwei, Forcolin, Giulio Tiziano, Forland, Blake Christopher, Formica, Andrea, Forster, Fabian Alexander, Forti, Alessandra, Fortin, Etienne Marie, Foti, Maria Giovanna, Fournier, Daniel, Fox, Harald, Andrei, Victor, Francavilla, Paolo, Francescato, Simone, Franchini, Matteo, Franchino, Silvia, Francis, David, Franco, Luca, Franconi, Laura, Franklin, Melissa, Frattari, Guglielmo, Freeman, Patrick Moriishi, Anelli, Christopher Ryan, Freund, Benjamin, Spolidoro Freund, Werner, Freundlich, Elena Murielle, Frizzell, Dylan Cooper, Froidevaux, Daniel, Frost, James, Fujimoto, Minori, Fullana Torregrosa, Esteban, Fusayasu, Takahiro, Fuster Verdu, Juan, Angelidakis, Stylianos, Gabrielli, Alessandro, Gabrielli, Andrea, Gadow, Paul Philipp, Gagliardi, Guido, Gagnon, Louis-guillaume, Gallardo, Gabriel, Gallas, Elizabeth, Gallop, Bruce Joseph, Gamboa Goni, Rodrigo, Gan, KK, Angerami, Aaron, Garcia Pascual, Juan Antonio, Gan, Kock Kiam, Ganguly, Sanmay, Gao, Jun, Gao, Yanyan, Gao, Yongsheng, Garay Walls, Francisca, Garcia, Carmen, Garcia Navarro, Jose Enrique, Garcia, Juanan, Anisenkov, Alexey, Garcia-sciveres, Maurice, Gardner Jr, Robert William, Garelli, Nicoletta, Gargiulo, Simona, Garner, Christopher Andrew, Garonne, Vincent, Gasiorowski, Sean Joseph, Do Nascimento Gaspar, Philipp, Gatta, Maurizio, Gaudio, Gabriella, Annovi, Alberto, Gauzzi, Paolo, Gavrilenko, Igor, Gavrilyuk, Alexander, Gavriliuk, Aleksandr, Gay, Colin Warren, Gaycken, Goetz, Gazis, Evangelos, Geanta, Andrei Alexandru, Gee, Carolyn, Gee, Norman, Antel, Claire, Geisen, Jannik, Geisen, Marc, Gemme, Claudia, Genest, Marie-helene, Geng, Cong, Gentile, Simonetta, Gentsos, Christos, George, Simon, Geralis, Theodoros, Gerlach, Lino Oscar, Anthony, Matthew Thomas, Gessinger-befurt, Paul, Gessner, Gregor, Ghasemi Bostanabad, Meisam, Ghneimat, Mazuza, Ghosh, Aishik, Ghosh, Anindya, Giacobbe, Benedetto, Giagu, Stefano, Giangiacomi, Nico, Giannetti, Paola, Antipov, Egor, Giannini, Antonio, Giannini, Giulia, Gibson, Stephen, Gignac, Matthew, Gil, Damian Tomasz, Gilbert, Benjamin Jacob, Gillberg, Dag, Gilles, Geoffrey, Gillwald, Nils, Gingrich, Douglas, Abramowicz, Halina, Antonelli, Mario, Giordani, MarioPaolo, Gingrich, Doug, Giordani, Mapo, Giraud, Pierre-francois, Giugliarelli, Gilberto, Giugni, Danilo, Giuli, Francesco, Gkaitatzis, Stamatios, Gkialas, Ioannis, Gkougkousis, Evangelos, Antrim, Daniel Joseph, Gkougkousis, Vagelis, Gkountoumis, Panagiotis, Gladilin, Leonid, Glasman, Claudia, Glaysher, Paul, Gledhill, Galen Rhodes, Gnesi, Ivan, Goblirsch-kolb, Maximilian Emanuel, Godin, Dominique, Goldfarb, Steven, Anulli, Fabio, Golling, Tobias, Golubkov, Dmitry, Da Silva Gomes, Agostinho, Goncalves Gama, Rafael, Morais Silva Goncalo, Ricardo Jose, Gonella, Giulia, Gonella, Laura, Gongadze, Alexi, Gonnella, Francesco, Gonski, Julia Lynne, Aoki, Masato, Gonzalez De La Hoz, Santiago, Gonzalez Fernandez, Sergio, Gonzalez Lopez, Ricardo, Gonzalez Renteria, Cesar, Gonzalez Suarez, Rebeca, Gonzalez Sevilla, Sergio, Gonzalvo Rodriguez, Galo Rafael, Goossens, Luc, Gorasia, Nandish Arjan, Gorbounov, Petr, Aparisi Pozo, Javier Alberto, Gordon, Howard, Gorini, Benedetto, Gorini, Edoardo, Gorisek, Andrej, Goshaw, Alfred, Grillo, Alexander, Goshaw, Al, Gostkin, Mikhail, Gottardo, Carlo Alberto, Gouighri, Mohamed, Aparo, Marco, Goussiou, Anna, Govender, Nicolin, Goy, Corinne, Grabowska-bold, Iwona, Gramstad, Eirik, Grancagnolo, Sergio, Grandi, Mario, Grachev, Vadim, Gravila, Paul, Gravili, Francesco Giuseppe, Aperio Bella, Ludovica, Gray, Chloe, Gray, Heather, Green, Barry, Grefe, Christian, Gregor, Ingrid, Grenier, Philippe, Grevtsov, Kirill, Grieco, Chiara, Grieser, Nathan Allen, Grillo, Alex, Aranzabal Barrio, Nordin, Grimm, Kathryn, Grinstein, Sebastian, Grivaz, Jean-francois, Groh, Sabrina, Gross, Eilam, Grosse-knetter, Joern, Grout, Zara Jane, Grud, Christopher Ryan, Grummer, Aidan, Grundy, James Cameron, Araujo Ferraz, Victor, Guan, Liang, Guan, Wen, Gubbels, Chris, Guenther, Jaroslav, Gubbels, Christopher, Guerrero Rojas, Jesus, Guescini, Francesco, Guest, Dan, Guest, Daniel, Gugel, Ralf, Pereira, Rodrigo, Guida, Alessandro, Guillemin, Thibault, Guindon, Stefan, Guo, Jun, Guo, Ziyu, Gupta, Ruchi, Gurbuz, Saime, Gustavino, Giuliano, Guth, Manuel, Gutierrez, Phillip, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), De Castro , S., Fabbri , L., Gabrielli , A., Rinaldi , L., Semprini Cesari , N., Sioli , M., Villa , M., Zoccoli , A., Bellagamba , L., Boscherini , D., Bruni , A., Bruni , G., Giacobbe , B., Polini , A., Sbarra , C., Sidoti , A., Franchini , M., Romano , M., Valentinetti , S., Alberghi , G. L., Lasagni Manghi , F, Massa , L., Vittori , C., Alfonsi , F, Cabras , G., Cervelli , A., Negrini , M., Todome , K., Carratta , G., Cavalli , N., Clissa , L., ATLAS collaboration, Aad, G., Abbott, B., Abbott, D. C., Abud, A. A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adam, L., Bourdarios, C. A., Adamczyk, L., Adamek, L., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Akesson, T. P. A., Akilli, E., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Albicocco, P., Verzini, M. J. A., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Alison, J., Allaire, C., Allbrooke, B. M. M., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Camelia, E. A., Estevez, M. A., Alviggi, M. G., Coutinho, Y. A., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Dos Santos, S. P. A., Amoroso, S., Amrouche, C. S., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Anderson, J. T., Andrean, S. Y., Andreazza, A., Andrei, V., Anelli, C. R., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Pozo, J. A. A., Aparo, M. A., Bella, L. A., Aranzabal, N., Ferraz, V. A., Pereira, R. A., Arcangeletti, C., Arce, A. T. H., Arguin, J. -F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Tame, Z. P. A., Artoni, G., Asada, H., Asai, K., Asai, S., Asawatavonvanich, T., Asbah, N., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Atmasiddha, P. A., Augsten, K., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Backman, F., Bagnaia, P., Bahmani, M., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Gupta, D. B., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barillari, T., Barisits, M. -S., Barkeloo, J., Barklow, T., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Navarro, L. B., Barreiro, F., da Costa, J. B. G., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bassalat, A., Basso, M. J., Basson, C. R., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. S., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. P., Becker, K., Becot, C., Beddall, A., Beddall, A. J., Bednyakov, V. A., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beisiegel, F., Belfkir, M., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Benekos, N., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Kuutmann, E. B., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bylund, O. B., Bethke, S., Betti, A., Bevan, A. J., Bhatta, S., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birch-Sykes, C. J., Birman, M., Bisanz, T., Biswal, J. P., Biswas, D., Bitadze, A., Bittrich, C., Bjorke, K., Blair, R. E., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Bobbink, G. J., Bobrovnikov, V. S., Bogavac, D., Bogdan, M., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bomben, M., Bona, M., Bonilla, J. S., Boonekamp, M., Booth, C. D., Borbely, A. G., Borecka-Bielska, H. M., Borgna, L. S., Borisov, A., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Sola, J. D. B., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bouquet, R., Bourlis, G., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Madden, W. D. B., Brendlinger, K., Brener, R., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I., Brock, R., Brooijmans, G., Brooks, W. K., Brost, E., de Renstrom, P. A. B., Bruers, B., Bruncko, D., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Bryant, P., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Bugge, M. K., Bulekov, O., Bullard, B. A., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burr, J. T. P., Burton, C. D., Burzynski, J. C., Buscher, V., Buschmann, E., Bussey, P. J., Butler, J. M., Buttar, C. M., Butterworth, J. M., Buttinger, W., Vazquez, C. J. B., Buzykaev, A. R., Cabras, G., Urban, S. C., Caforio, D., Cai, H., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Caltabiano, A., Lopez, S. 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E., Corriveau, F., Costa, M. J., Costanza, F., Costanzo, D., Cowan, G., Cowley, J. W., Crane, J., Cranmer, K., Creager, R. A., Crepe-Renaudin, S., Crescioli, F., Cristinziani, M., Cristoforetti, M., Croft, V., Crone, G. J., Crosetti, G., Cueto, A., Donszelmann, T. C., Cui, H., Cukierman, A. R., Cunningham, W. R., Czekierda, S., Czodrowski, P., Czurylo, M. M., da Cunha Sargedas De Sousa, M. J., da Fonseca Pinto, J. V., da Via, C., Dabrowski, W., Dachs, F., Dado, T., Dahbi, S., Dai, T., Dallapiccola, C., Dam, M., D'Amen, G., D'Amico, V., Damp, J., Dandoy, J. R., Daneri, M. F., Danninger, M., Dao, V., Darbo, G., Dartsi, O., Dattagupta, A., D'Auria, S., David, C., Davidek, T., Davis, D. R., Dawson, I., De, K., de Asmundis, R., de Beurs, M., de Castro, S., de Groot, N., de Jesus Pardal Vicente, M., de Jong, P., de la Torre, H., de Maria, A., de Pedis, D., de Salvo, A., de Sanctis, U., de Santis, M., de Santo, A., de Vivie De Regie, J. B., Dedovich, D. V., Deiana, A. M., Del Peso, J., Delabat Diaz, Y., Delgove, D., Deliot, F., Delitzsch, C. M., della Pietra, M., della Volpe, D., Dell'Acqua, A., Dell'Asta, L., Delmastro, M., Delporte, C., Delsart, P. A., Demers, S., Demichev, M., Demontigny, G., Denisov, S. P., D'Eramo, L., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Dette, K., Deutsch, C., Deviveiros, P. O., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Donato, C., Di Girolamo, A., Di Gregorio, G., Di Luca, A., Di Micco, B., Di Nardo, R., Di Sipio, R., Diaconu, C., Dias, F. A., Do Vale, T. D., Diaz, M. A., Capriles, F. G. D., Dickinson, J., Didenko, M., Diehl, E. B., Dietrich, J., Cornell, S. D., Pardos, C. D., Dimitrievska, A., Ding, W., Dingfelder, J., Dittmeier, S. J., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., Do Vale, M. A. B., Dobre, M., Dodsworth, D., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Dong, B., Donini, J., D'Onofrio, A., D'Onofrio, M., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drake, G., Drechsler, E., Dreyer, E., Dreyer, T., Drobac, A. S., Du, D., du Pree, T. A., Duan, Y., Dubinin, F., Dubovsky, M., Dubreuil, A., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., Dudder, A. C., D'Uffizi, M., Duflot, L., Duhrssen, M., Dulsen, C., Dumancic, M., Dumitriu, A. E., Dunford, M., Dungs, S., Duperrin, A., Yildiz, H. D., Duren, M., Durglishvili, A., Dutta, B., Duvnjak, D., Dyckes, G. I., Dyndal, M., Dysch, S., Dziedzic, B. S., Eggleston, M. G., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Jarrari, H., Ellajosyula, V., Ellert, M., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Emerman, A., Enari, Y., Erdmann, J., Ereditato, A., Erland, P. A., Errenst, M., Escalier, M., Escobar, C., Pastor, O. E., Etzion, E., Evans, G., Evans, H., Evans, M. O., Ezhilov, A., Fabbri, F., Fabbri, L., Fabiani, V., Facini, G., Fakhrutdinov, R. M., Falciano, S., Falke, P. J., Falke, S., Faltova, J., Fang, Y., Fanourakis, G., Fanti, M., Faraj, M., Farbin, A., Farilla, A., Farina, E. M., Farooque, T., Farrington, S. M., Farthouat, P., Fassi, F., Fassnacht, P., Fassouliotis, D., Giannelli, M. F., Fawcett, W. J., Fayard, L., Fedin, O. L., Fehr, A., Feickert, M., Feligioni, L., Fell, A., Feng, C., Feng, M., Fenton, M. J., Fenyuk, A. B., Ferguson, S. W., Ferrando, J., Ferrari, A., Ferrari, P., Ferrari, R., Ferrer, A., Ferrere, D., Ferretti, C., Fiedler, F., Filipcic, A., Filthaut, F., Finelli, K. D., Fiolhais, M. C. N., Fiorini, L., Fischer, F., Fischer, J., Fisher, W. C., Fitschen, T., Fleck, I., Fleischmann, P., Flick, T., Flierl, B. M., Flores, L., Castillo, L. R. F., Follega, F. M., Fomin, N., Foo, J. H., Forcolin, G. T., Forland, B. C., Formica, A., Forster, F. A., Forti, A. C., Fortin, E., Foti, M. G., Fournier, D., Fox, H., Francavilla, P., Francescato, S., Franchini, M., Franchino, S., Francis, D., Franco, L., Franconi, L., Franklin, M., Frattari, G., Freeman, P. M., Freund, B., Freund, W. S., Freundlich, E. M., Frizzell, D. C., Froidevaux, D., Frost, J. A., Fujimoto, M., Torregrosa, E. F., Fusayasu, T., Fuster, J., Gabrielli, A., Gadow, P., Gagliardi, G., Gagnon, L. G., Gallardo, G. E., Gallas, E. J., Gallop, B. J., Goni, R. G., Gan, K. K., Ganguly, S., Gao, J., Gao, Y., Gao, Y. S., Walls, F. M. G., Garcia, C., Navarro, J. E. G., Pascual, J. A. G., Garcia-Sciveres, M., Gardner, R. W., Garelli, N., Gargiulo, S., Garner, C. A., Garonne, V., Gasiorowski, S. J., Gaspar, P., Gatta, M., Gaudio, G., Gauzzi, P., Gavrilenko, I. L., Gavrilyuk, A., Gay, C., Gaycken, G., Gazis, E. N., Geanta, A. A., Gee, C. M., Gee, C. N. P., Geisen, J., Geisen, M., Gemme, C., Genest, M. H., Geng, C., Gentile, S., Gentsos, C., George, S., Geralis, T., Gerlach, L. O., Gessinger-Befurt, P., Gessner, G., Bostanabad, M. G., Ghneimat, M., Ghosh, A., Giacobbe, B., Giagu, S., Giangiacomi, N., Giannetti, P., Giannini, A., Giannini, G., Gibson, S. M., Gignac, M., Gil, D. T., Gilbert, B. J., Gillberg, D., Gilles, G., Gillwald, N. E. K., Gingrich, D. M., Giordani, M. P., Giraud, P. F., Giugliarelli, G., Giugni, D., Giuli, F., Gkaitatzis, S., Gkialas, I., Gkougkousis, E. L., Gkountoumis, P., Gladilin, L. K., Glasman, C., Glaysher, P. C. F., Gledhill, G. R., Gnesi, I., Goblirsch-Kolb, M., Godin, D., Goldfarb, S., Golling, T., Golubkov, D., Gomes, A., Gama, R. G., Goncalo, R., Gonella, G., Gonella, L., Gongadze, A., Gonnella, F., Gonski, J. L., de la Hoz, S. G., Fernandez, S. G., Lopez, R. G., Renteria, C. G., Suarez, R. G., Gonzalez-Sevilla, S., Rodriguez, G. R. G., Goossens, L., Gorasia, N. A., Gorbounov, P. A., Gordon, H. A., Gorini, B., Gorini, E., Gorisek, A., Goshaw, A. T., Gostkin, M. I., Gottardo, C. A., Gouighri, M., Goussiou, A. G., Govender, N., Goy, C., Grabowska-Bold, I., Gramstad, E., Grancagnolo, S., Grandi, M., Gratchev, V., Gravila, P. M., Gravili, F. G., Gray, C., Gray, H. M., Green, B., Grefe, C., Gregor, I. M., Grenier, P., Grevtsov, K., Grieco, C., Grieser, N. A., Grillo, A. A., Grimm, K., Grinstein, S., Grivaz, J. -F., Groh, S., Gross, E., Grosse-Knetter, J., Grout, Z. J., Grud, C., Grummer, A., Grundy, J. C., Guan, L., Guan, W., Gubbels, C., Guenther, J., Rojas, J. G. R. G., Guescini, F., Guest, D., Gugel, R., Guida, A., Guillemin, T., Guindon, S., Guo, J., Guo, Z., Gupta, R., Gurbuz, S., Gustavino, G., Guth, M., Gutierrez, P., Zagazeta, L. F. G., Gutschow, C., Guyot, C., Gwenlan, C., Gwilliam, C. B., Haaland, E. S., Haas, A., Haber, C., Hadavand, H. K., Hadef, A., Haleem, M., Haley, J., Hall, J. J., Halladjian, G., Hallewell, G. D., Hamano, K., Hamdaoui, H., Hamer, M., Hamity, G. N., Han, K., Han, L., Han, S., Han, Y. F., Hanagaki, K., Hance, M., Hank, M. D., Hankache, R., Hansen, E., Hansen, J. 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[0000-0002-1928-1717], Xu, T. [0000-0002-0215-6151], Xu, W. [0000-0001-5661-1917], Xu, Y. [0000-0001-9563-4804], Xu, Z. [0000-0001-9571-3131], Xu, Z. [0000-0001-9602-4901], Yabsley, B. [0000-0002-2680-0474], Yacoob, S. [0000-0001-6977-3456], Yallup, D.P. [0000-0003-4716-5817], Yamaguchi, N. [0000-0002-6885-282X], Yamaguchi, Y. [0000-0002-3725-4800], Yamazaki, T. [0000-0003-0411-3590], Yamazaki, Y. [0000-0003-3710-6995], Yan, Z. [0000-0002-2483-4937], Yang, H.J. [0000-0001-7367-1380], Yang, H.T. [0000-0003-3554-7113], Yang, S. [0000-0002-0204-984X], Yang, T. [0000-0002-4996-1924], Yang, X. [0000-0002-1452-9824], Yang, X. [0000-0002-9201-0972], Yang, Y. [0000-0001-8524-1855], Yang, Z. [0000-0002-7374-2334], Yao, W-M. [0000-0002-3335-1988], Yap, Y.C. [0000-0001-8939-666X], Ye, H. [0000-0002-4886-9851], Ye, J. [0000-0001-9274-707X], Ye, S. [0000-0002-7864-4282], Yeletskikh, I. [0000-0003-0586-7052], Yexley, M.R. [0000-0002-1827-9201], Yin, P. [0000-0003-2174-807X], Yorita, K. [0000-0003-1988-8401], Yoshihara, K. [0000-0002-3656-2326], Young, C.J.S. [0000-0001-5858-6639], Young, C. [0000-0003-3268-3486], Yuan, R. [0000-0002-8452-0315], Yue, X. [0000-0001-6956-3205], Zaazoua, M. [0000-0002-4105-2988], Zabinski, B. [0000-0001-5626-0993], Zacharis, G. [0000-0002-3156-4453], Zaffaroni, E. [0000-0003-1714-9218], Zahreddine, J. [0000-0002-6932-2804], Zaitsev, A.M. [0000-0002-4961-8368], Zakareishvili, T. [0000-0001-7909-4772], Zakharchuk, N. [0000-0002-4963-8836], Zambito, S. [0000-0002-4499-2545], Zanzi, D. [0000-0002-1222-7937], Zeißner, S.V. [0000-0002-9037-2152], Zeitnitz, C. [0000-0003-2280-8636], Zemaityte, G. [0000-0001-6331-3272], Zeng, J.C. [0000-0002-2029-2659], Zenin, O. [0000-0002-5447-1989], Ženiš, T. [0000-0001-8265-6916], Zenz, S. [0000-0002-9720-1794], Zerradi, S. [0000-0001-9101-3226], Zerwas, D. [0000-0002-4198-3029], Zgubič, M. [0000-0002-5110-5959], Zhang, B. [0000-0002-9726-6707], Zhang, D.F. [0000-0001-7335-4983], Zhang, G. [0000-0002-5706-7180], Zhang, J. [0000-0002-9907-838X], Zhang, K. [0000-0002-9778-9209], Zhang, L. [0000-0002-9336-9338], Zhang, L. [0000-0001-5241-6559], Zhang, M. [0000-0001-8659-5727], Zhang, R. [0000-0002-8265-474X], Zhang, X. [0000-0003-4731-0754], Zhang, X. [0000-0003-4341-1603], Zhang, Y. [0000-0002-4554-2554], Zhang, Z. [0000-0002-7853-9079], Zhao, P. [0000-0003-0054-8749], Zhao, Y. [0000-0003-0494-6728], Zhao, Z. [0000-0001-6758-3974], Zhemchugov, A. [0000-0002-3360-4965], Zheng, Z. [0000-0002-8323-7753], Zhong, D. [0000-0001-9377-650X], Zhou, C. [0000-0001-5904-7258], Zhou, H. [0000-0002-7986-9045], Zhou, M. [0000-0001-7223-8403], Zhou, N. [0000-0002-1775-2511], Zhu, C.G. [0000-0001-8015-3901], Zhu, C. [0000-0002-5918-9050], Zhu, H.L. [0000-0001-8479-1345], Zhu, H. [0000-0001-8066-7048], Zhu, J. [0000-0002-5278-2855], Zhu, Y. [0000-0002-7306-1053], Zhuang, X. [0000-0003-0996-3279], Zhukov, K. [0000-0003-2468-9634], Zhulanov, V. [0000-0002-0306-9199], Zieminska, D. [0000-0002-6311-7420], Zimine, N.I. [0000-0003-0277-4870], Zimmermann, S. [0000-0002-1529-8925], Živković, L. [0000-0003-4236-8930], Zoccoli, A. [0000-0002-0993-6185], Zoch, K. [0000-0003-2138-6187], Zorbas, T.G. [0000-0003-2073-4901], Zou, R. [0000-0002-0542-1264], Zwalinski, L. [0000-0002-9397-2313], Apollo - University of Cambridge Repository, Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2890, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, and Atlas, Collaboration
Subjects: Kjerne- og elementærpartikkelfysikk: 431 [VDP], Physics - Instrumentation and Detectors, Computer science, data acquisition, Tracking (particle physics), 01 natural sciences, Online farms and online filtering, High Energy Physics - Experiment, Subatomär fysik, High Energy Physics - Experiment (hep-ex), Data acquisition, Software, cluster finding, Subatomic Physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], hardware, Calibration and fitting methods, Cluster finding, Modular electronics, Pattern recognition, Trigger concepts and systems (hardware and software), Detectors and Experimental Techniques, Instrumentation, Mathematical Physics, FPGA, Settore FIS/01, Large Hadron Collider, Pattern recognition, cluster finding, calibration and fitting methods, track data analysis, Detector, integrated circuit, microstrip [semiconductor detector], Modular electronic, Instrumentation and Detectors (physics.ins-det), calibration and fitting methods, ATLAS, medicine.anatomical_structure, Nuclear and elementary particle physics: 431 [VDP], Pattern recognition (psychology), design [electronics], semiconductor detector: microstrip, LHC, Computer hardware, performance, Particle Physics - Experiment, 530 Physics, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, Accelerator Physics and Instrumentation, programming, Calibration and fitting method, semiconductor detector: pixel, Atlas (anatomy), 0103 physical sciences, medicine, High Energy Physics, ddc:610, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Field-programmable gate array, numerical calculations, pixel [semiconductor detector], 010308 nuclear & particles physics, business.industry, paper, bibliography, Acceleratorfysik och instrumentering, trigger, LHC, Particle Tracking, High-level Trigger, Particle Tracking, efficiency, High-level Trigger, data management, business, Hadron-hadron collisions, electronics: design
Abstract: We thank CERN for the very successful operation of the LHC, as well as the support staff from our institutions without whom ATLAS could not be operated efficiently. We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerba¼an; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRC KI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZŠ, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada; Be¼ing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union; Investissements d’Avenir Labex, Investissements d’Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO TEO and GenT Programmes Generalitat Valenciana, Spain; Göran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom. The crucial computing support from all WLCG partners is acknowledged gratefully, in particular from CERN, the ATLAS Tier-1 facilities at TRIUMF (Canada), NDGF (Denmark, Norway, Sweden), CC-IN2P3 (France), KIT/GridKA (Germany), INFN-CNAF(Italy), NL-T1 (Netherlands), PIC (Spain), ASGC (Taiwan), RAL (U.K.) and BNL (U.S.A.), the Tier-2 facilities worldwide and large non-WLCG resource providers. Major contributors of computing resources are listed in ref. [52]., The ATLAS Fast TracKer (FTK) was designed to provide full tracking for the ATLAS high-level trigger by using pattern recognition based on Associative Memory (AM) chips and fitting in high-speed field programmable gate arrays. The tracks found by the FTK are based on inputs from all modules of the pixel and silicon microstrip trackers. The as-built FTK system and components are described, as is the online software used to control them while running in the ATLAS data acquisition system. Also described is the simulation of the FTK hardware and the optimization of the AM pattern banks. An optimization for long-lived particles with large impact parameter values is included. A test of the FTK system with the data playback facility that allowed the FTK to be commissioned during the shutdown between Run 2 and Run 3 of the LHC is reported. The resulting tracks from part of the FTK system covering a limited η-ϕ region of the detector are compared with the output from the FTK simulation. It is shown that FTK performance is in good agreement with the simulation., ANPCyT, Argentina, YerPhI, Armenia, ARC, Australia, BMWFW and FWF, Austria, ANAS, Azerbaijan, SSTC, Belarus, CNPq and FAPESP, Brazil, NSERC, NRC and CFI, Canada, CERN, ANID, Chile, CAS, MOST and NSFC, China, COLCIENCIAS, Colombia, MSMT CR, MPO CR and VSC CR, Czech Republic, DNRF and DNSRC, Denmark, IN2P3-CNRS and CEA-DRF/IRFU, France, SRNSFG, Georgia, BMBF, HGF and MPG, Germany, GSRT, Greece, RGC and Hong Kong SAR, China, ISF and Benoziyo Center, Israel, INFN, Italy, MEXT and JSPS, Japan, CNRST, Morocco, NWO, Netherlands, RCN, Norway, MNiSW and NCN, Poland, FCT, Portugal, MNE/IFA, Romania, JINR, MES of Russia and NRC KI, Russian Federation, MESTD, Serbia, MSSR, Slovakia, ARRS and MIZŠ, Slovenia, DST/NRF, South Africa, MICINN, Spain, SRC and Wallenberg Foundation, Sweden, SERI, SNSF and Cantons of Bern and Geneva, Switzerland, MOST, Taiwan, TAEK, Turkey, STFC, United Kingdom, DOE and NSF, United States of America, BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada, Bejiing Municipal Science & Technology Commission, China, COST, ERC, ERDF, Horizon 2020 and Marie Skłodowska-Curie Actions, European Union, Investissements d’Avenir Labex, Investissements d’Avenir Idex and ANR, France, DFG and AvH Foundation, Germany, Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece, BSF-NSF and GIF, Israel, La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain, Göran Gustafssons Stiftelse, Sweden, The Royal Society and Leverhulme Trust, United Kingdom
Published: 2021

50. Measurements of sensor radiation damage in the ATLAS inner detector using leakage currents

Author: Aad, G., Abbott, B., Abbott, D. C., Abed Abud, A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., Abouzeid, O. S., Abraham, N. L., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B. S., Achkar, B., Adam, L., Adam Bourdarios, C., Adamczyk, L., Adamek, L., Adelman, J., Adersberger, M., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Åkesson, T. P. A., Akilli, E., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Allaire, C., Allbrooke, B. M. M., Allen, B. W., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Alunno Camelia, E., Alvarez Estevez, M., Alviggi, M. G., Amaral Coutinho, Y., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., An, F., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Andrei, V., Anelli, C. R., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J. A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Aparo, M. A., Aperio Bella, L., Aranzabal, N., Araujo Ferraz, V., Pereira, R. A., Arcangeletti, C., Arce, A. T. H., Arduh, F. A., Arguin, J. -F., Argyropoulos, S., Arling, J. -H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Arrubarrena Tame, Z. P., Artoni, G., Asada, H., Asai, K., Asai, S., Asawatavonvanich, T., Asbah, N. A., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Augsten, K., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Backman, F., Bagnaia, P., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Bakshi Gupta, D., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Banerjee, Sw., Barak, L., Barbe, W. M., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barillari, T., Barisits, M. -S., Barkeloo, J., Barklow, T., Barnea, R., Barnett, B. M., Barnett, R. M., Barnovska-Blenessy, Z., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães Da Costa, J., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bassalat, A., Basso, M. J., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. S., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. C., Beck, H. P., Becker, K., Becot, C., Beddall, A., Beddall, A. J., Bednyakov, V. A., Bedognetti, M., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beisiegel, F., Belfkir, M., Bell, A. S., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Benekos, N., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bessidskaia Bylund, O., Besson, N., Bethani, A., Bethke, S., Betti, A., Bevan, A. J., Beyer, J., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Biedermann, D., Bielski, R., Bierwagen, K., Biesuz, N. V., Biglietti, M., Billoud, T. R. V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birch-Sykes, C. J., Birman, M., Bisanz, T., Biswal, J. P., Biswas, D., Bitadze, A., Bittrich, C., Bjørke, K., Blazek, T., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Bobbink, G. J., Bobrovnikov, V. S., Bocchetta, S. S., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bolz, A. E., Bomben, M., Bona, M., Bonilla, J. S., Boonekamp, M., Booth, C. D., Borbély, A. G., Borecka-Bielska, H. M., Borgna, L. S., Borisov, A., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Bossio Sola, J. D., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Breaden Madden, W. D., Brendlinger, K., Brener, R., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I., Brock, R., Brooijmans, G., Brooks, W. K., Brost, E., Bruckman De Renstrom, P. A., Brüers, B., Bruncko, D., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Bugge, M. K., Bührer, F., Bulekov, O., Bullard, B. A., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burr, J. T. P., Burton, C. D., Burzynski, J. C., Büscher, V., Buschmann, E., Bussey, P. J., Butler, J. M., Buttar, C. M., Butterworth, J. M., Butti, P., Buttinger, W., Buxo Vazquez, C. J., Buzatu, A., Buzykaev, A. R., Cabras, G., Cabrera Urbán, S., Caforio, D., Cai, H., Cairo, V. M. M., Cakir, O., Calace, N., Calafiura, P., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Caltabiano, A., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Camacho Toro, R., Camarda, S., Camarero Munoz, D., Camarri, P., Camerlingo, M. T., Cameron, D., Camincher, C., Campana, S., Campanelli, M., Camplani, A., Canale, V., Canesse, A., Cano Bret, M., Cantero, J., Cao, T., Cao, Y., Capeans Garrido, M. D. M., Capua, M., Cardarelli, R., Cardillo, F., Carducci, G., Carli, I., Carli, T., Carlino, G., Carlson, B. T., Carlson, E. M., Carminati, L., Carney, R. M. D., Caron, S., Carquin, E., Carrá, S., Carratta, G., Carter, J. W. S., Carter, T. M., Casado, M. P., Casha, A. F., Castiglia, E. G., Castillo, F. L., Castillo Garcia, L., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Cavaliere, V., Cavasinni, V., Celebi, E., Celli, F., Cerny, K., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chadi, Z., Chakraborty, D., Chan, J., Chan, W. S., Chan, W. Y., Chapman, J. D., Chargeishvili, B., Charlton, D. G., Charman, T. P., Chatterjee, M., Chau, C. C., Che, S., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chen, B., Chen, C., Chen, C. H., Chen, H., Chen, J., Chen, S., Chen, S. J., Chen, X., Chen, Y., Chen, Y. -H., Cheng, H. C., Cheng, H. J., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Cheu, E., Cheung, K., Chevalérias, T. J. A., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, I., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chow, Y. S., Christopher, L. D., Chu, M. C., Chu, X., Chudoba, J., Chwastowski, J. J., Chytka, L., Cieri, D., Ciesla, K. M., Cindro, V., Cioarǎ, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubotaru, D. A., Ciungu, B. M., Clark, A., Clark, M. R., Clark, P. J., Clawson, S. E., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Coelho Lopes De Sa, R., Cohen, H., Coimbra, A. E. C., Cole, B., Colijn, A. P., Collot, J., Conde Muiño, P., Connell, S. H., Connelly, I. A., Constantinescu, S., Conventi, F., Cooper-Sarkar, A. M., Cormier, F., Cormier, K. J. R., Corpe, L. D., Corradi, M., Corrigan, E. 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B., Simion, S., Simoniello, R., Simsek, S., Sinervo, P., Sinetckii, V., Singh, S., Sinha, S., Sioli, M., Siral, I., Sjölin, J., Skaf, A., Skorda, E., Skubic, P., Slawinska, M., Sliwa, K., Smakhtin, V., Smart, B. H., Smiesko, J., Smirnov, Y., Smirnova, L. N., Smirnova, O., Smith, E. A., Smith, H. A., Smizanska, M., Smolek, K., Smykiewicz, A., Snesarev, A. A., Snoek, H. L., Snyder, I. M., Snyder, S., Sobie, R., Soffer, A., Søgaard, A., Sohns, F., Solans Sanchez, C. A., Soldevila, U., Solodkov, A. A., Solomon, S., Soloshenko, A., Solovyanov, O. V., Solovyev, V., Sommer, P., Son, H., Sonay, A., Song, W. Y., Sopczak, A., Sopio, A. L., Sopkova, F., Sottocornola, S., Soualah, R., Soukharev, A. M., Soumaimi, Z., South, D., Spagnolo, S., Spalla, M., Spangenberg, M., Spanò, F., Sperlich, D., Spieker, T. M., Spigo, G., Spina, M., Spiteri, D. P., Spousta, M., Stabile, A., Stamas, B. L., Stamen, R., Stamenkovic, M., Stampekis, A., Stanecka, E., Stanislaus, B., Stanitzki, M. 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M., Trincaz-Duvoid, S., Trischuk, D. A., Trischuk, W., Trocmé, B., Trofymov, A., Troncon, C., Trovato, F., Truong, L., Trzebinski, M., Trzupek, A., Tsai, F., Tsiareshka, P. V., Tsirigotis, A., Tsiskaridze, V., Tskhadadze, E. G., Tsopoulou, M., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Tsur, O., Tsybychev, D., Tu, Y., Tudorache, A., Tudorache, V., Tuna, A. N., Turchikhin, S., Turgeman, D., Turk Cakir, I., Turner, R. J., Turra, R., Tuts, P. M., Tzamarias, S., Tzanis, P., Tzovara, E., Uchida, K., Ukegawa, F., Unal, G., Unal, M., Undrus, A., Unel, G., Ungaro, F. C., Uno, K., Urban, J., Urquijo, P., Usai, G., Ushioda, R., Uysal, Z., Vacek, V., Vachon, B., Vadla, K. O. H., Vafeiadis, T., Valderanis, C., Valdes Santurio, E., Valente, M., Valentinetti, S., Valero, A., Valéry, L., Vallance, R. A., Vallier, A., Valls Ferrer, J. A., Van Daalen, T. R., Van Gemmeren, P., Van Stroud, S., Van Vulpen, I., Vanadia, M., Vandelli, W., Vandenbroucke, M., Vandewall, E. 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G., Zou, R., Zou, W., Zwalinski, L., Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Della Pietra, Massimo, Merola, Leonardo, Massarotti, Paolo, Conventi, Francesco, Rossi, Elvira, Carlino, Giampaolo, de Asmundis, Riccardo, Di Donato, Camilla, Doria, Alessandra, Iengo, Paolo, Izzo, Vincenzo, Perrella, Sabrina, Sekhniaidze, Givi, Cirotto, Francesco, Lavorgna, Marco, Giannini, Antonio, Atlas, Collaboration, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Centre de Calcul de l'IN2P3 (CC-IN2P3), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ATLAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Współautorami artykułu są członkowie ATLAS Collaboration w liczbie 2842, Aad, G, Bachas, K, Chiodini, G, Gorini, E, Gravili, F, Longo, L, Primavera, M, Reale, M, Schioppa, E, Spagnolo, S, Ventura, A, ATLAS Collaboration, And, Aad, G. 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[0000-0002-6885-282X], Yamaguchi, Y. [0000-0002-3725-4800], Yamauchi, H. [0000-0003-2123-5311], Yamazaki, T. [0000-0003-0411-3590], Yamazaki, Y. [0000-0003-3710-6995], Yan, Z. [0000-0002-2483-4937], Yang, H.J. [0000-0001-7367-1380], Yang, H.T. [0000-0003-3554-7113], Yang, S. [0000-0002-0204-984X], Yang, T. [0000-0002-4996-1924], Yang, X. [0000-0002-1452-9824], Yang, X. [0000-0002-9201-0972], Yang, Y. [0000-0001-8524-1855], Yang, Z. [0000-0002-7374-2334], Yap, Y.C. [0000-0001-8939-666X], Ye, H. [0000-0002-4886-9851], Ye, J. [0000-0001-9274-707X], Ye, S. [0000-0002-7864-4282], Yeletskikh, I. [0000-0003-0586-7052], Yexley, M.R. [0000-0002-1827-9201], Yin, P. [0000-0003-2174-807X], Yorita, K. [0000-0003-1988-8401], Yoshihara, K. [0000-0002-3656-2326], Young, C.J.S. [0000-0001-5858-6639], Young, C. [0000-0003-3268-3486], Yuan, R. [0000-0002-8452-0315], Yue, X. [0000-0001-6956-3205], Zaazoua, M. [0000-0002-4105-2988], Zabinski, B. [0000-0001-5626-0993], Zacharis, G. [0000-0002-3156-4453], Zaffaroni, E. [0000-0003-1714-9218], Zahreddine, J. [0000-0002-6932-2804], Zaitsev, A.M. [0000-0002-4961-8368], Zakareishvili, T. [0000-0001-7909-4772], Zakharchuk, N. [0000-0002-4963-8836], Zambito, S. [0000-0002-4499-2545], Zanzi, D. [0000-0002-1222-7937], Zeißner, S.V. [0000-0002-9037-2152], Zeitnitz, C. [0000-0003-2280-8636], Zemaityte, G. [0000-0001-6331-3272], Zeng, J.C. [0000-0002-2029-2659], Zenin, O. [0000-0002-5447-1989], ženiš, T. [0000-0001-8265-6916], Zenz, S. [0000-0002-9720-1794], Zerradi, S. [0000-0001-9101-3226], Zerwas, D. [0000-0002-4198-3029], Zgubič, M. [0000-0002-5110-5959], Zhang, B. [0000-0002-9726-6707], Zhang, D.F. [0000-0001-7335-4983], Zhang, G. [0000-0002-5706-7180], Zhang, J. [0000-0002-9907-838X], Zhang, K. [0000-0002-9778-9209], Zhang, L. [0000-0002-9336-9338], Zhang, L. [0000-0001-5241-6559], Zhang, M. [0000-0001-8659-5727], Zhang, R. [0000-0002-8265-474X], Zhang, X. [0000-0003-4731-0754], Zhang, X. 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[0000-0002-0779-8815], Zwalinski, L. [0000-0002-9397-2313], and Apollo - University of Cambridge Repository
Subjects: Physics::Instrumentation and Detectors, design, 01 natural sciences, damage [radiation], High Energy Physics - Experiment, design [detector], High Energy Physics - Experiment (hep-ex), NIEL damage, pixel, scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Detector modelling and simulations I (interaction of radiation with matter, interaction of photons with matter, interaction of hadrons with matter, etc), Radiation damage to detector materials (solid state), tracking detector, Instrumentation, Mathematical Physics, Leakage (electronics), radiation: damage, Physics, Settore FIS/01, Large Hadron Collider, track data analysis, 4. Education, pixel [detector], Detector, microstrip [semiconductor detector], interaction of photons with matter, Monte Carlo [numerical calculations], ATLAS, semiconductor, charged particle, Semiconductor detector, interaction of hadrons with matter, medicine.anatomical_structure, CERN LHC Coll, semiconductor detector: microstrip, LHC, colliding beams [p p], numerical calculations: Monte Carlo, LHC, NIEL damage, silicon sensor, damage, Particle Physics - Experiment, safety, p p: scattering, 530 Physics, energy loss, Detector modelling and simulations I (interaction of radiation with matter, FOS: Physical sciences, LHC, ATLAS, High Energy Physics, Radiation, Optics, Atlas (anatomy), 0103 physical sciences, medicine, detector: pixel, High Energy Physics, ddc:610, 010306 general physics, detector: design, etc), Pixel, detector, 010308 nuclear & particles physics, business.industry, paper, radiation, Semiconductor, 13. Climate action, silicon sensor, semiconductor detector, High Energy Physics::Experiment, business, microstrip, p p: colliding beams, experimental results
Abstract: We acknowledge the support of ANPCyT, Argentina; YerPhI, Armenia; ARC, Australia; BMWFW and FWF, Austria; ANAS, Azerba 1/4 an; SSTC, Belarus; CNPq and FAPESP, Brazil; NSERC, NRC and CFI, Canada; CERN; ANID, Chile; CAS, MOST and NSFC, China; COLCIENCIAS, Colombia; MSMT CR, MPO CR and VSC CR, Czech Republic; DNRF and DNSRC, Denmark; IN2P3-CNRS and CEA-DRF/IRFU, France; SRNSFG, Georgia; BMBF, HGF and MPG, Germany; GSRT, Greece; RGC and Hong Kong SAR, China; ISF and Benoziyo Center, Israel; INFN, Italy; MEXT and JSPS, Japan; CNRST, Morocco; NWO, Netherlands; RCN, Norway; MNiSW and NCN, Poland; FCT, Portugal; MNE/IFA, Romania; JINR; MES of Russia and NRC KI, Russian Federation; MESTD, Serbia; MSSR, Slovakia; ARRS and MIZS, Slovenia; DST/NRF, South Africa; MICINN, Spain; SRC and Wallenberg Foundation, Sweden; SERI, SNSF and Cantons of Bern and Geneva, Switzerland; MOST, Taiwan; TAEK, Turkey; STFC, United Kingdom; DOE and NSF, United States of America. In addition, individual groups and members have received support from BCKDF, CANARIE, Compute Canada, CRC and IVADO, Canada; Be 1/4 ing Municipal Science & Technology Commission, China; COST, ERC, ERDF, Horizon 2020 and Marie Sklodowska-Curie Actions, European Union; Investissements d'Avenir Labex, Investissements d'Avenir Idex and ANR, France; DFG and AvH Foundation, Germany; Herakleitos, Thales and Aristeia programmes co-financed by EU-ESF and the Greek NSRF, Greece; BSF-NSF and GIF, Israel; La Caixa Banking Foundation, CERCA Programme Generalitat de Catalunya and PROMETEO and GenT Programmes Generalitat Valenciana, Spain; Goran Gustafssons Stiftelse, Sweden; The Royal Society and Leverhulme Trust, United Kingdom., Non-ionizing energy loss causes bulk damage to the silicon sensors of the ATLAS pixel and strip detectors. This damage has important implications for data-taking operations, charged-particle track reconstruction, detector simulations, and physics analysis. This paper presents simulations and measurements of the leakage current in the ATLAS pixel detector and semiconductor tracker as a function of location in the detector and time, using data collected in Run 1 (2010-2012) and Run 2 (2015-2018) of the Large Hadron Collider. The extracted fluence shows a much stronger vertical bar z vertical bar-dependence in the innermost layers than is seen in simulation. Furthermore, the overall fluence on the second innermost layer is significantly higher than in simulation, with better agreement in layers at higher radii. These measurements are important for validating the simulation models and can be used in part to justify safety factors for future detector designs and interventions., ANPCyT, YerPhI, Armenia, Australian Research Council, Austrian Science Fund (FWF), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Natural Sciences and Engineering Research Council of Canada (NSERC), NRC, Canada, Canada Foundation for Innovation, ANID, Chile, Chinese Academy of Sciences, Ministry of Science and Technology, China, National Natural Science Foundation of China (NSFC), Departamento Administrativo de Ciencia, Tecnologia e Innovacion Colciencias, Ministry of Education, Youth & Sports - Czech Republic, Czech Republic Government, DNRF, Denmark, Federal Ministry of Education & Research (BMBF), HGF, Germany, Max Planck Society, Greek Ministry of Development-GSRT, Israel Science Foundation, Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT), Japan Society for the Promotion of Science, Netherlands Organization for Scientific Research (NWO), Netherlands Government, RCN, Norway, Ministry of Science and Higher Education, Poland, NCN, Poland, Portuguese Foundation for Science and Technology, European Commission, JINR, Russian Federation, NRC KI, Russian Federation, MSSR, Slovakia, Slovenian Research Agency - Slovenia, DST/NRF, South Africa, Spanish Government, SRC, Sweden, Wallenberg Foundation, Sweden, Ministry of Science and Technology, Taiwan, Ministry of Energy & Natural Resources - Turkey, UK Research & Innovation (UKRI), Science & Technology Facilities Council (STFC), United States Department of Energy (DOE), National Science Foundation (NSF), BCKDF, Canada, CRC, Canada, COST, European Union, European Research Council (ERC), ERDF, European Union, Horizon 2020, European Union, Marie Sklodowska-Curie Actions, European Union, French National Research Agency (ANR), German Research Foundation (DFG), Alexander von Humboldt Foundation, EU-ESF, Greece, Greek NSRF, Greece, BSF-NSF, Israel, German-Israeli Foundation for Scientific Research and Development, La Caixa Banking Foundation, Spain, BMWFW, Austria, CERN, Danish Natural Science Research Council, Centre National de la Recherche Scientifique (CNRS), CEA-DRF/IRFU, France, RGC, China, Hong Kong SAR, China, Benoziyo Center, Israel, Istituto Nazionale di Fisica Nucleare (INFN), CNRST, Morocco, MNE/IFA, Romania, Ministry of Education, Science & Technological Development, Serbia, MIZS, Slovenia, SERI, Switzerland, Swiss National Science Foundation (SNSF), Canton of Bern, Switzerland, Canton of Geneva, Switzerland, CANARIE, Canada, Compute Canada, Canada, IVADO, Canada, Be 1/4 ing Municipal Science & Technology Commission, China, Herakleitos programme, Thales Group, Aristeia programme, CERCA Programme Generalitat de Catalunya, Spain PROMETEO Programme Generalitat Valenciana, Spain, GenT Programme Generalitat Valenciana, Spain, Goran Gustafssons Stiftelse, Sweden, Royal Society of London, Leverhulme Trust
Published: 2021

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