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1. Prevention of SARS-CoV-2 transmission during a large, live, indoor gathering (SPRING): a non-inferiority, randomised, controlled trial

Author: Frantz Foissac, Claire Poyart, Marie Laure Néré, Malika Seguineau, Laure Choupeaux, Séverine Delarue, Sarah Schmitt, Hendy Abdoul, Eric Dufour, Alexis Olivier, Maud Salmona, Marine Minier, Sébastien Tonglet, Guillaume Masson, Xavier Lescure, Jean-Marc Treluyer, Audrey Gabassi, Constance Delaugerre, Jérôme Le Goff, Nabil Gastli, and Solen Kernéis
Subjects: education.field_of_study, medicine.medical_specialty, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Population, MEDLINE, COVID-19, Articles, law.invention, Test (assessment), Infectious Diseases, Transmission (mechanics), Non inferiority, Randomized controlled trial, law, Clinical endpoint, Physical therapy, medicine, Humans, education, business
Abstract: Background Mass indoor gatherings were banned in early 2020 to prevent the spread of SARS-CoV-2. We aimed to assess, under controlled conditions, whether infection rates among attendees at a large, indoor gathering event would be similar to those in non-attendees, given implementation of a comprehensive prevention strategy including antigen-screening within 3 days, medical mask wearing, and optimised ventilation. Methods The non-inferiority, prospective, open-label, randomised, controlled SPRING trial was done on attendees at a live indoor concert held in the Accor Arena on May 29, 2021 in Paris, France. Participants, aged 18–45 years, recruited via a dedicated website, had no comorbidities, COVID-19 symptoms, or recent case contact, and had had a negative rapid antigen diagnostic test within 3 days before the concert. Participants were randomly allocated in a 2:1 ratio to the experimental group (attendees) or to the control group (non-attendees). The allocation sequence was computer-generated by means of permuted blocks of sizes three, six, or nine, with no stratification. The primary outcome measure was the number of patients who were SARS-CoV-2-positive by RT-PCR test on self-collected saliva 7 days post-gathering in the per-protocol population (non-inferiority margin
Published: 2022

2. Are solo driving commuters ready to switch to carpool? Heterogeneity of preferences in Lyon's urban area

Author: Alix Le Goff, Charles Raux, and Guillaume Monchambert
Subjects: geography, Discrete choice, geography.geographical_feature_category, business.industry, Geography, Planning and Development, Transportation, Sample (statistics), Urban area, Value of time, Travel time, Transport engineering, Carpool, Public transport, TRIPS architecture, Business
Abstract: We conduct a discrete choice experiment on 1556 solo-driving commuters in Lyon, France to estimate the values of end-to-end travel time (VoTT) of commuting trips in the presence of a HOV-lane for four modes: Solo Driver, Carpool Driver, Carpool Passenger and Public Transport. Using discrete choice models, we find a strong heterogeneity in VoTT across modes and individuals. The analysis of individual heterogeneity distinguishes four behavior patterns: reluctant to mode change (20% of our sample), preferring the three alternative modes over solo driver (35%), preferring public transport (12%) and preferring driver modes whether solo or carpool (32%). We find that current solo drivers are more likely to switch to carpooling as a driver rather than as a passenger. As suggested by our simulations aimed at marginally changing mode shares, carpool passenger will be the scarce resource if one wants to decrease car traffic by stimulating carpooling for commuting trips.
Published: 2022

3. Raising up to the climate challenge - Understanding and assessing farmers’ strategies to build their resilience. A comparative analysis between Ugandan and Swiss farmers

Author: Johan Six, Dominique Barjolle, Maria Hernandez Lagana, Ulysse Le Goff, Adelaide Sander, and Suzanne Phillips
Subjects: Sociology and Political Science, business.industry, Emerging technologies, Farming system resilience agroecology Switzerland Uganda, Geography, Planning and Development, Context (language use), Citizen journalism, Development, Local community, Agriculture, Food systems, Resilience (network), business, Environmental planning, Agroecology
Abstract: Climate change is a growing concern for farmers and food systems across the globe, raising interest in their resilience to climate change. Thus, exploring farm resilience in various contexts may help understand its prerequisites and build context and scale-specific strategies. Using an adaptive cycle framework through a survey-based assessment of the resilience of farmers in Uganda and Switzerland, we assessed farmers’ resilience across a set of 13 behaviour-based indicators. Farm resilience appeared to be differently constructed in each context. While in Uganda, farmers maintain a high degree of resilience through local community interconnections and agroecological practices, Swiss farmers rely more on institutional support, high access to information and new technologies. Additionally, the self-perceived resilience proved to be strongly and positively correlated to the overall farm resilience, further supporting the potential for more participatory approaches. In a complex field where methodologies are numerous and contexts vary dramatically, flexible yet consistent tools based on participatory approaches may pave the way to context-specific recommendations to stakeholders to strengthen farming system resilience under different context found around the world., Journal of Rural Studies, 89, ISSN:0743-0167
Published: 2022

4. Surging bloodstream infections and antimicrobial resistance during the first wave of COVID–19: a study in a large multihospital institution in the Paris region

Author: Rishma Amarsy, David Trystram, Emmanuelle Cambau, Catherine Monteil, Sandra Fournier, Juliette Oliary, Helga Junot, Pierre Sabatier, Raphaël Porcher, Jérôme Robert, Vincent Jarlier, Guillaume Arlet, Laurence Armand Lefevre, Alexandra Aubry, Laurent Belec, Béatrice Bercot, Stéphane Bonacorsi, Vincent Calvez, Etienne Carbonnelle, Stéphane Chevaliez, Jean-Winoc Decousser, Constance Delaugerre, Diane Descamps, Florence Doucet-Populaire, Jean-Louis Gaillard, Antoine Garbarg- Chenon, Elyanne Gault, Jean-Louis Herrmann, Jérôme Le Goff, Jean-Christophe Lucet, Jean-Luc Mainardi, Anne-Geneviève Marcellin, Laurence Morand-Joubert, Xavier Nassif, Jean-Michel Pawlotsky, Anne-Marie Roque Afonso, Martin Rottman, Christine Rouzioux, Flore Rozenberg, François Simon, Nicolas Veziris, David Skurnik, Jean-Ralph Zahar, Guilene Barnaud, Typhaine Billard Pomares, Gaëlle Cuzon, Dominique Decré, Alexandra Doloy, Jean-Luc Donay, Laurence Drieux-Rouzet, Isabelle Durand, Agnès Ferroni, Vincent Fihman, Nicolas Fortineau, Camille Gomart, Nathalie Grall, Christelle Guillet Caruba, Françoise Jaureguy, Valérie Lalande, Luce Landraud, Véronique Leflon, Patricia Mariani, Liliana Mihaila, Didier Moissenet, Latifa Noussair, Isabelle Podglajen, Isabelle Poilane, Hélène Poupet, Emilie Rondinaud, Valérie Sivadon Tardy, Charlotte Verdet, Emmanuelle Vigier, Sophie Vimont Billarant, Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Bactériologie et d'Hygiène Hospitalière [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Lariboisière-Fernand-Widal [APHP], Service de Biochimie Métabolique [CHU Pitié-Salpêtrière], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and HAL-SU, Gestionnaire
Subjects: Microbiology (medical), medicine.medical_specialty, Klebsiella pneumoniae, medicine.drug_class, Cephalosporin, Bacteremia, Infectious and parasitic diseases, RC109-216, medicine.disease_cause, Antimicrobial resistance, Blood culture, Article, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, Internal medicine, Sepsis, Drug Resistance, Bacterial, medicine, Humans, 030212 general & internal medicine, Pandemics, Retrospective Studies, 0303 health sciences, Cross Infection, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, biology, 030306 microbiology, Pseudomonas aeruginosa, business.industry, SARS-CoV-2, Incidence (epidemiology), COVID-19, Bloodstream infection incidence, General Medicine, Enterobacter, biology.organism_classification, COVID-19, blood culture, 3. Good health, Anti-Bacterial Agents, Infectious Diseases, Staphylococcus aureus, Antibiotic consumption, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Objectives: This study measured the impact of the first wave of COVID-19 pandemic (COVID-19) (March–April 2020) on the incidence of bloodstream infections (BSIs) at Assistance Publique – Hôpitaux de Paris (APHP), the largest multisite public healthcare institution in France. Methods: The number of patient admission blood cultures (BCs) collected, number of positive BCs, and antibiotic resistance and consumption were analysed retrospectively for the first quarter of 2020, and also for the first quarter of 2019 for comparison, in 25 APHP hospitals (ca. 14 000 beds). Results: Up to a fourth of patients admitted in March–April 2020 in these hospitals had COVID-19. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, and separately for the major pathogens (Escherichia coli, Klebsiella pneumoniae, enterococci, Staphylococcus aureus, Pseudomonas aeruginosa, yeasts). A sharp increase in the rate of BSIs caused by microorganisms resistant to third-generation cephalosporins (3GC) was also observed in March–April 2020, particularly in K. pneumoniae, enterobacterial species naturally producing inducible AmpC (Enterobacter cloacae...), and P. aeruginosa. A concomitant increase in 3GC consumption occurred. Conclusions: The COVID-19 pandemic had a strong impact on hospital management and also unfavourable effects on severe infections, antimicrobial resistance, and laboratory work diagnostics.
Published: 2022

5. Usage de Jeux de hasard et d’argent et d’Internet dans une population de patients en demande de soins en addictologie–Étude multicentrique

Author: E. Beaugrard, D. Le Goff, M. Tirmont, X. Guillery, Morgane Guillou-Landreat, Delphine Lever, Antoine Dany, P. Lechifflart, G. Descarpentries, and I. Levenez
Subjects: Sexual addiction, medicine.medical_specialty, education.field_of_study, Internet use, business.industry, media_common.quotation_subject, Addiction, Population, medicine.disease, Psychiatry and Mental health, Promotion (rank), Arts and Humanities (miscellaneous), Compulsive buying, mental disorders, medicine, The Internet, Psychiatry, education, Psychology, business, Video game, media_common
Abstract: BACKGROUND Transversal grouping of addictions under the heading "Substance related and addictive disorders" in the DSM-5 has led to a common policy on addictions and the promotion of addiction services covering all types of addictions, including behavioral addictions. MATERIAL AND METHODS The main objective of this study was to describe the prevalence of problem gambling in a population of patients seeking treatment in addictive disorders center. Secondary objectives were: to describe the use of Internet and the prevalence of gaming disorder, sexual addiction and compulsive buying online ; to describe a population of patients consulting in addictive disorders center; to explore associated factors related to problem gambling. A self-questionnaire was built, evaluating the socio-demographic elements, the addiction pathway, problem gambling and Internet use with a focus on video game disorder, sexual addiction and compulsive buying. It was offered to consultants from five addictology centers in Brittany. RESULTS 252 patients seeking treatment for addictive disorders were included. Problem gambling was present in 9.9 % of patients. Problem gamblers were more likely to have been asked about their gambling by the addictology team than other patients. The rate of identification of gambling habits, whether in addiction or outside, was generally low. Internet use was 83 %. The prevalence of other online behavioral addictions was low. DISCUSSION AND CONCLUSION The prevalence of problem gambling is almost 4 times higher among addictology consultants, compared to the general population, probably related to addictive comorbidities. The identification of gambling habits concerned a small proportion of the patients included, whether in specialized care or outside. There is significant room for improvement in the identification of problem gambling, in addictology and beyond. It is important to question gambling habits for any reason for addiction consultation and to repeat this identification over time. As the Internet is widely used by addictology consultants, it can represent a key element in care, both in the identification of behavioral addictions and in follow-up.
Published: 2021

6. Perceived patient-centered communication, quality of life, and symptom burden in individuals with ovarian cancer

Author: Meghan Underhill-Blazey, Rachel Pozzar, Fangxin Hong, Marilyn J. Hammer, James A. Tulsky, Niya Xiong, Alexi A. Wright, Donna L. Berry, and Barbara A. Goff
Subjects: Disease, Cost of Illness, Quality of life, Patient-Centered Care, Humans, Medicine, Patient Reported Outcome Measures, Qualitative Research, Aged, Ovarian Neoplasms, Physician-Patient Relations, Descriptive statistics, business.industry, Communication, Uncertainty, Symptom burden, Obstetrics and Gynecology, Middle Aged, medicine.disease, System characteristics, Cross-Sectional Studies, Oncology, Quality of Life, bacteria, Female, Self Report, business, Communication quality, Ovarian cancer, Patient centered, Clinical psychology
Abstract: Objective To describe perceptions of patient-centered communication (PCC); assess whether physician specialty, patient characteristics, or health system characteristics are associated with PCC; and identify associations between PCC, health-related quality of life (HRQoL), and symptom burden among individuals with ovarian cancer. Methods Cross-sectional, descriptive survey of English-speaking adults with ovarian cancer. PCC, HRQoL, and ovarian cancer symptom burden were assessed with the PCC-Ca-36, the FACT-G, and the FOSI-18, respectively. PCC-Ca-36 scores were summarized using descriptive statistics. Predictors of PCC-Ca-36, FACT-G, and FOSI-18 scores were identified using multiple linear regression. Results Participants (n = 176) had a mean age of 59.4 years (SD = 12.1). The majority (65.9%) had advanced-stage disease, while 42.0% were receiving treatment. The mean PCC-Ca-36 total score was 4.09 (SD = 0.78) out of a possible 5, indicating participants often perceived that clinicians engaged in PCC. Among the PCC functions, participants reported that clinicians least often enabled patient self-management (M = 3.65, SD = 0.99), responded to emotions (M = 3.84, SD = 1.04), and managed uncertainty (M = 3.91, SD = 0.93). In multivariable analyses, neither physician specialty nor patient and health system characteristics were significantly associated with overall PCC. Greater overall PCC predicted better overall HRQoL; better social/family, emotional, and functional well-being; and lower overall and physical symptom burden (all p ≤ 0.05). Conclusion Greater PCC is significantly associated with better HRQoL and lower symptom burden among individuals with ovarian cancer. Practice implications Promotion of PCC is a promising strategy to improve patient-reported outcomes in the ovarian cancer care setting.
Published: 2021

7. Extraction and preservation of lycopene: A review of the advancements offered by the value chain of nanotechnology

Author: Carlos Molina-Ramírez, Piedad Gañán, Catalina Gómez Hoyos, Arantxa Eceiza, Robin Zuluaga, J. Velásquez-Cock, H. Douglas Goff, Lina María Vélez, and Angélica María Serpa Guerra
Subjects: food.ingredient, Food industry, business.industry, Food additive, Extraction (chemistry), Nanotechnology, Health benefits, Lycopene, chemistry.chemical_compound, food, chemistry, Food processing, business, Food Science, Biotechnology
Abstract: The chemical structure of lycopene has been associated with significant health benefits as an antioxidant, resulting in promising applications as a food additive. However, lycopene is susceptible to chemical changes, such as isomerization and decomposition, when exposed to light and high temperatures. Therefore, lycopene stability during its isolation, food processing, and storage has sparked interest. Isolation includes the extraction of lycopene from vegetable cells by various means and its preservation to protect the biocompound from decomposition. This review explores opportunities to improve lycopene extraction and preservation through the nanotechnology value chain, a framework introduced in 2004. The nanotools explored to extract lycopene are techniques already used in the food industry, such as high-pressure homogenization and microfluidization, which allow the use of food-grade solvents, such as edible oils. Lycopene in oil can be protected by a Pickering emulsion or nanoemulsion, developed with the same nanotools used in lycopene extraction.
Published: 2021

8. Elevated serum sodium in recipients of liver transplantation has a substantial impact on outcomes

Author: Cameron R. Goff, John A. Goss, Spencer C. Barrett, Caroline R. Christmann, Fasiha Kanwal, Malcolm F McDonald, Adrish Anand, Abbas Rana, Thao Galvan, George Cholankeril, Tahir H Malik, and Stephanie S. Keeling
Subjects: medicine.medical_specialty, Sodium, medicine.medical_treatment, chemistry.chemical_element, Liver transplantation, Gastroenterology, Elevated serum, chemistry.chemical_compound, Risk Factors, Internal medicine, Humans, Medicine, Retrospective Studies, Transplantation, Creatinine, Hypernatremia, business.industry, Proportional hazards model, medicine.disease, Liver Transplantation, surgical procedures, operative, chemistry, Graft survival, business, Hyponatremia
Abstract: Dysnatremias are a rare but significant event in liver transplantation. While recipient pre-transplant hypernatremia has been demonstrated to increase post-transplant mortality, the degree of hypernatremia and the impact of its resolution have been less well characterized. Here, we used multivariate Cox regression with a comprehensive list of donor and recipient factors in order to conduct a robust multivariate retrospective database study of 54,311 United Network for Organ Sharing (UNOS) liver transplant patients to analyze the effect of pre-transplant serum sodium on post-transplant mortality, post-transplant length of hospitalization, and post-transplant graft survival. Mortality and graft failure increased in a stepwise fashion with increasing pre-transplant hypernatremia: 145 -150 mEq/L (HR = 1.118 and HR = 1.113), 150-155 mEq/L (HR = 1.324 and HR = 1.306), and > 155 mEq/L (HR = 1.623 and HR = 1.661). Pre-transplant hypo- and hypernatremia also increased length of post-transplant hospitalization: < 125 mEq/L (HR = 1.098), 125-130 mEq/L (HR = 1.060), 145 -150 mEq/L (HR = 1.140), and 150-155 mEq/L (HR = 1.358). Resolution of hypernatremia showed no significant difference in mortality compared with normonatremia, while unresolved hypernatremia significantly increased mortality (HR = 1.254), including a durable long-term increased mortality risk for patients with creatinine < 2 mg/dL and MELD < 25. Pre-transplant hypernatremia serves as a morbid prognostic indicator for post-transplant morbidity and mortality.
Published: 2021

9. Ectopic fat deposition in populations of black African ancestry: A systematic review and meta-analysis

Author: Graham J. Kemp, Reuben M Reed, Daniel J. Cuthbertson, Sarah J Nevitt, Louise M Goff, and Martin Whyte
Subjects: medicine.medical_specialty, South asia, Black african, business.industry, Endocrinology, Diabetes and Metabolism, Hypercholesterolemia, Black People, Adipose tissue, General Medicine, Type 2 diabetes, Intra-Abdominal Fat, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, Diabetes mellitus, Internal medicine, Meta-analysis, Ethnicity, Internal Medicine, Humans, Medicine, business, Systematic search
Abstract: Aims In populations of black African ancestry (BA), a paradox exists whereby lower visceral adipose tissue is found despite their high risk for type 2 diabetes (T2D). This systematic review investigates ethnic differences in other ectopic fat depots (intrahepatic lipid: IHL; intramyocellular lipid: IMCL and intrapancreatic lipid; IPL) to help contextualise their potential contribution to T2D risk. Methods A systematic literature search was performed in December 2020 to identify studies reporting at least one ectopic fat comparison between BA and one/more other ethnicity. For IHL, a meta-analysis was carried out with studies considered comparable based on the method of measurement. Results Twenty-eight studies were included (IHL: n = 20; IMCL: n = 8; IPL: n = 4). Meta-analysis of 11 studies investigating IHL revealed that it was lower in BA populations vs pooled ethnic comparators (MD −1.35%, 95% CI −1.55 to −1.16, I2 = 85%, P I2 = 79%, P I2 = 81%, P I2 = 78%, P = 0.005). However, heterogeneity was high in all analyses. Most studies found no significant differences in IMCL between BA and WE. Few studies investigated IPL, however, indicated that IPL is lower in BA compared to WE and HIS. Conclusion The discordance between ectopic fat and greater risk for T2D in BA populations raises questions around its contribution to T2D pathophysiology in BA.
Published: 2021

10. The Place of Pharmacotherapy in Alcohol Use Disorder Management in Family Practice - A Systematic Review

Author: Guillou Landreat Morgane, Le Goff Delphine, Kergoat Guillaume, and Le Reste Jean Yves
Subjects: Pharmacology, medicine.medical_specialty, business.industry, MEDLINE, Craving, Primary care, Alcohol use disorder, medicine.disease, Alcoholism, Cross-Sectional Studies, Pharmacotherapy, Systematic review, Prescription database, Family medicine, Disulfiram, mental disorders, Drug Discovery, medicine, Humans, Medical prescription, medicine.symptom, Family Practice, business, Follow-Up Studies
Abstract: Background and Aims: Alcohol use disorders (AUD) are among the most prevalent mental disorders around the world, yet still remain the most undertreated. Many studies report the low rate of treatment uptake, less than 20%, among people with AUD. Among those accessing care, a large majority only approach their GP for help. Therefore, primary care is a strategic setting for the identification and the management of AUD. International recommendations stress AUD pharmacotherapy for withdrawal and craving management, but very few studies have shown interest in the management of AUDs in primary care. The main objective of this study was to analyse pharmacotherapy in AUD management in primary care by means of a systematic literature review. Methods: A systematic literature review (PRISMA) was carried out. 5 databases were screened: PUBMED via MEDLINE, LiSSa, the SUDOC catalogue, PASCAL and EMBASE. Search algorithms were used integrating the concepts of pharmacotherapy management, alcohol use disorders and primary care, only in the English language. Results: 296 studies were selected and 10 were included. One was a follow-up study on the national prescription database, while four were cross-sectional studies with an auto-questionnaire survey. Of the 10 studies included, two were conducted in Europe, five in North America, two in Australia and one in South Africa. These pharmacotherapy studies were concerned with the anti-craving treatment, and 3 types of medications were used: Disulfiram, Acamprosate and Naltrexone. Factors identified as limiting or facilitating prescriptions concerned cost, indications, efficacy, training and adjuncts to pharmacotherapy. Conclusion: Knowledge and prescription of pharmacotherapy for AUD, more specifically, anti-craving treatment, is insufficient in primary care. There is a lack of data and studies on the efficacy of anti-craving treatment in primary care. Guidelines for AUD management, including psychological and medical management and pharmacotherapy, do exist but have not been adapted to primary care practice. Barriers and facilitators of pharmacotherapy prescription in AUD in primary care were identified in this study.
Published: 2021

11. International train the trainer neonatal antibiotic stewardship program for South African pharmacists

Author: Pavel Prusakov, Pablo J. Sánchez, Angeliki P Messina, Ama Sakoa Annor, Dini Mawela, Sithembiso Velaphi, Dena van den Bergh, Debra A. Goff, Pinky Lea Chirwa, Azraa Cassim, Sonya Kolman, Benedict C. Nwomeh, Julie E. Mangino, Natalie Schellack, and Lindie Van Tonder
Subjects: Neonatal intensive care unit, Nursing, business.industry, Global health, Pharmaceutical Science, Antimicrobial stewardship, Antibiotic Stewardship, Medicine, Pharmacology (medical), Pharmacy, business, Train the trainer
Published: 2021

12. Is Medication Adherence Predictive of Cardiovascular Outcomes and Blood Pressure Control? The Systolic Blood Pressure Intervention Trial (SPRINT)

Author: Mara Z. Vitolins, Carolyn H Still, David C. Goff, Michael V. Rocco, Stephen P. Glasser, William E. Haley, and Stacey S. Cofield
Subjects: Ajhype/Ajh-08, medicine.medical_specialty, hypertension, Myocardial Infarction, Medication Adherence, Internal medicine, Internal Medicine, Medicine, Humans, AcademicSubjects/MED00200, Myocardial infarction, Stroke, Antihypertensive Agents, business.industry, SPRINT, Standard treatment, blood pressure, Odds ratio, Original Articles, medicine.disease, Confidence interval, Clinical trial, Treatment, Blood pressure, predictors, Heart failure, AcademicSubjects/SCI00960, business
Abstract: BACKGROUND Adherence to study medications is crucial to evaluating treatment effects in clinical trials. To assess whether in the SPRINT trial, adherence and cardiovascular outcomes are associated regardless of intervention assignment. METHODS This study included 9,361 participants aged ≥50 years, recruited from 102 clinics. Participants were randomized to a Standard Treatment Group (targeted systolic blood pressure [SBP], Graphical Abstract Graphical Abstract
Published: 2021

13. Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients

Author: Karl A. Lautenschlager, Cameron M. Shawver, Grant Schroeder, Pei Han, John P. McCallin, Catherine Bresee, Zulma Gazit, Brandon J. Goff, Aaron M. Betts, Maxim Bez, Dan Gazit, Marcel M. Maya, Gadi Pelled, Debiao Li, Tristan T. Lai, Matthew B. Hoch, Howard E. Gill, Margaux M. Salas, Cody Lynch, and Zhengwei Zhou
Subjects: Adult, Male, Discogenic pain, Science, Intervertebral Disc Degeneration, Article, Diagnosis, Differential, medicine, Chemical Exchange Saturation Transfer MRI, Humans, Intervertebral Disc, Multidisciplinary, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Intervertebral disc, Magnetic resonance imaging, Translational research, Low back pain, Magnetic Resonance Imaging, medicine.anatomical_structure, Saturation transfer, Biomarker (medicine), Feasibility Studies, Medicine, Female, medicine.symptom, Chronic Pain, Nuclear medicine, business, Low Back Pain, Biomarkers
Abstract: Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan.
Published: 2021

14. Utilité des suivis de cohortes de patients de la vraie-vie par questionnaires pour évaluer l’effet des traitements sur l’ensemble de la population

Author: Benoit Le Goff, Jean-Marie Berthelot, and Christelle Darrieutort-Laffite
Subjects: Rheumatology, business.industry, Medicine, business
Published: 2022

15. Lyme arthritis in Western Europe: a multicentre retrospective study

Author: Brigitte Degeilh, Xavier Guennic, Benoit Le Goff, Jean-David Albert, Clémence Corre, Guillaume Coiffier, Solène Patrat-Delon, Pierre Tattevin, Marine Ferreyra, Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), CHU Pontchaillou [Rennes], Centre hospitalier Rene Pleven de Dinan, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU de Saint-Brieuc, ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
Subjects: Adult, Male, Microbiology (medical), medicine.medical_specialty, [SDV]Life Sciences [q-bio], Lyme Arthritis, Polymerase Chain Reaction, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Borreliella, Borrelia burgdorferi Group, Interquartile range, Internal medicine, Borrelia, Synovial Fluid, medicine, Monoarthritis, Humans, Synovial fluid, Serologic Tests, Borrelia burgdorferi, Lyme borreliosis, Retrospective Studies, 030304 developmental biology, 030203 arthritis & rheumatology, Doxycycline, Lyme Disease, 0303 health sciences, biology, business.industry, Lyme arthritis, General Medicine, Middle Aged, Amoxicillin, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Antibodies, Bacterial, Anti-Bacterial Agents, 3. Good health, Europe, Infectious Diseases, business, medicine.drug
Abstract: International audience; To characterize Lyme arthritis, with a focus on management, and outcome. Observational retrospective multicentre study in Western France, of all consecutive cases of Lyme arthritis, documented by Borrelia burgdorferi IgG on ELISA serological testing, confirmed by Western blot, with or without positive Borrelia PCR in synovial fluid, with no alternative diagnosis. We enrolled 52 patients (29 males), with a mean age of 43 +/- 19.4 years. Most patients had monoarthritis (n = 43, 82.7%), involving the knee (n = 51, 98.1%), with a median delay between symptoms onset and Lyme arthritis diagnosis of 5 months (interquartile range, 1.5-8). Synovial fluid analysis yielded median white cell count of 16,000/mm(3) (9230-40,500), and positive PCR in 16 cases (39%), for B. burgdorferi sensu stricto (n = 5), B. garinii (n = 5), B. afzelii (n = 3), and undetermined (n = 3). All patients received antibiotics, for a median duration of 28 days (21-30), with doxycycline (n = 44, 84.6%), ceftriaxone (n = 6, 11.5%), or amoxicillin (n = 2). Twelve patients (23.1%) also received intra-articular injection of glucocorticoids as first-line treatment. Of 47 patients with follow-up, 35 (74.5%) had complete resolution of Lyme arthritis. Lyme arthritis in Western Europe may be due to B. burgdorferi ss, B. afzelii, or B. garinii. Clinical presentation is similar to Lyme arthritis in North America (i.e. chronic knee monoarthritis), with low sensitivity of synovial fluid PCR (39%).
Published: 2021

16. Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults — United States, March–July 2021

Author: Tenforde, Mark W., Self, Wesley H., Naioti, Eric A., Ginde, Adit A., Douin, David J., Olson, Samantha M., Talbot, H. Keipp, Casey, Jonathan D., Mohr, Nicholas M., Zepeski, Anne, Gaglani, Manjusha, McNeal, Tresa, Ghamande, Shekhar, Shapiro, Nathan I., Gibbs, Kevin W., Files, D. Clark, Hager, David N., Shehu, Arber, Prekker, Matthew E., Erickson, Heidi L., Gong, Michelle N., Mohamed, Amira, Henning, Daniel J., Steingrub, Jay S., Peltan, Ithan D., Brown, Samuel M., Martin, Emily T., Monto, Arnold S., Khan, Akram, Hough, Catherine L., Busse, Laurence W., ten Lohuis, Caitlin C., Duggal, Abhijit, Wilson, Jennifer G., Gordon, Alexandra June, Qadir, Nida, Chang, Steven Y., Mallow, Christopher, Rivas, Carolina, Babcock, Hilary M., Kwon, Jennie H., Exline, Matthew C., Halasa, Natasha, Chappell, James D., Lauring, Adam S., Grijalva, Carlos G., Rice, Todd W., Jones, Ian D., Stubblefield, William B., Baughman, Adrienne, Womack, Kelsey N., Lindsell, Christopher J., Hart, Kimberly W., Zhu, Yuwei, Stephenson, Meagan, Schrag, Stephanie J., Kobayashi, Miwako, Verani, Jennifer R., Patel, Manish M., Calhoun, Nicole, Murthy, Kempapura, Herrick, Judy, McKillop, Amanda, Hoffman, Eric, Zayed, Martha, Smith, Michael, Settele, Natalie, Ettlinger, Jason, Priest, Elisa, Thomas, Jennifer, Arroliga, Alejandro, Beeram, Madhava, Kindle, Ryan, Kozikowski, Lori-Ann, De Souza, Lesley, Ouellette, Scott, Thornton-Thompson, Sherell, Tyler, Patrick, Mehkri, Omar, Ashok, Kiran, Gole, Susan, King, Alexander, Poynter, Bryan, Stanley, Nicholas, Hendrickson, Audrey, Maruggi, Ellen, Scharber, Tyler, Jorgensen, Jeffrey, Bowers, Robert, King, Jennifer, Aston, Valerie, Armbruster, Brent, Rothman, Richard E., Nair, Rahul, Chen, Jen-Ting (Tina), Karow, Sarah, Robart, Emily, Maldonado, Paulo Nunes, Khan, Maryiam, So, Preston, Levitt, Joe, Perez, Cynthia, Visweswaran, Anita, Roque, Jonasel, Rivera, Adreanne, Frankel, Trevor, Howell, Michelle, Friedel, Jennifer, Goff, Jennifer, Huynh, David, Tozier, Michael, Driver, Conner, Carricato, Michael, Foster, Alexandra, Nassar, Paul, Stout, Lori, Sibenaller, Zita, Walter, Alicia, Mares, Jasmine, Olson, Logan, Clinansmith, Bradley, Gershengorn, Hayley, McSpadden, EJ, Truscon, Rachel, Kaniclides, Anne, Thomas, Lara, Bielak, Ramsay, Valvano, Weronika Damek, Fong, Rebecca, Fitzsimmons, William J., Blair, Christopher, Valesano, Andrew L., Gilbert, Julie, Crider, Christine D., Steinbock, Kyle A., Paulson, Thomas C., Anderson, Layla A., Kampe, Christy, Johnson, Jakea, McHenry, Rendie, Blair, Marcia, Conway, Douglas, LaRose, Mary, Landreth, Leigha, Hicks, Madeline, Parks, Lisa, Bongu, Jahnavi, McDonald, David, Cass, Candice, Seiler, Sondra, Park, David, Hink, Tiffany, Wallace, Meghan, Burnham, Carey-Ann, and Arter, Olivia G.
Subjects: Adult, Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Health (social science), COVID-19 Vaccines, Time Factors, Coronavirus disease 2019 (COVID-19), Adolescent, Epidemiology, Health, Toxicology and Mutagenesis, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Young Adult, Health Information Management, Internal medicine, Medicine, Humans, Full Report, Young adult, Aged, Vaccines, Synthetic, business.industry, Vaccination, COVID-19, General Medicine, High effectiveness, Middle Aged, Confidence interval, United States, Hospitalization, Female, business
Abstract: Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19-associated hospitalizations (1-4) measured shortly after vaccination; longer follow-up is needed to assess durability of protection. In an evaluation at 21 hospitals in 18 states, the duration of mRNA vaccine (Pfizer-BioNTech or Moderna) effectiveness (VE) against COVID-19-associated hospitalizations was assessed among adults aged ≥18 years. Among 3,089 hospitalized adults (including 1,194 COVID-19 case-patients and 1,895 non-COVID-19 control-patients), the median age was 59 years, 48.7% were female, and 21.1% had an immunocompromising condition. Overall, 141 (11.8%) case-patients and 988 (52.1%) controls were fully vaccinated (defined as receipt of the second dose of Pfizer-BioNTech or Moderna mRNA COVID-19 vaccines ≥14 days before illness onset), with a median interval of 65 days (range = 14-166 days) after receipt of second dose. VE against COVID-19-associated hospitalization during the full surveillance period was 86% (95% confidence interval [CI] = 82%-88%) overall and 90% (95% CI = 87%-92%) among adults without immunocompromising conditions. VE against COVID-19- associated hospitalization was 86% (95% CI = 82%-90%) 2-12 weeks and 84% (95% CI = 77%-90%) 13-24 weeks from receipt of the second vaccine dose, with no significant change between these periods (p = 0.854). Whole genome sequencing of 454 case-patient specimens found that 242 (53.3%) belonged to the B.1.1.7 (Alpha) lineage and 74 (16.3%) to the B.1.617.2 (Delta) lineage. Effectiveness of mRNA vaccines against COVID-19-associated hospitalization was sustained over a 24-week period, including among groups at higher risk for severe COVID-19; ongoing monitoring is needed as new SARS-CoV-2 variants emerge. To reduce their risk for hospitalization, all eligible persons should be offered COVID-19 vaccination.
Published: 2021

17. Clinical characteristics and management of olecranon and prepatellar septic bursitis in a multicentre study

Author: Géraldine Bart, Benoit Le Goff, Laurie Charret, Grégoire Cormier, David Boutoille, Emmanuelle Dernis, Christelle Darrieutort-Laffite, and Emmanuel Hoppe
Subjects: Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Bursitis, medicine.drug_class, Olecranon, 030106 microbiology, Antibiotics, medicine.disease_cause, Septic bursitis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Antibiotic therapy, Elbow Joint, medicine, Humans, Pharmacology (medical), Olecranon Process, Pharmacology, 030222 orthopedics, Streptococcus, business.industry, Bacterial Infections, Middle Aged, medicine.disease, Comorbidity, Anti-Bacterial Agents, Infectious Diseases, medicine.anatomical_structure, Cellulitis, Female, business
Abstract: Background No current guidelines are available for managing septic bursitis (SB). Objectives To describe the clinical characteristics and management of olecranon and prepatellar SB in five French tertiary care centres. Methods This is a retrospective observational multicentre study. SB was diagnosed on the basis of positive cultures of bursal aspirate. In the absence of positive bursal fluid, the diagnosis came from typical clinical presentation, exclusion of other causes of bursitis and favourable response to antibiotic therapy. Results We included 272 patients (median age of 53 years, 85.3% male and 22.8% with at least one comorbidity). A microorganism was identified in 184 patients (67.6%), from bursal fluids in all but 4. We identified staphylococci in 135 samples (73.4%), streptococci in 35 (19%) and 10 (5.5%) were polymicrobial, while 43/223 bursal samples remained sterile (19.3%). Forty-nine patients (18%) were managed without bursal fluid analysis. Antibiotic treatment was initially administered IV in 41% and this route was preferred in case of fever (P = 0.003) or extensive cellulitis (P = 0.002). Seventy-one (26%) patients were treated surgically. A low failure rate was observed (n = 16/272, 5.9%) and failures were more frequent when the antibiotic therapy lasted Conclusions Despite variable treatments, SB resolved in the majority of cases even when the treatment was exclusively medical. The success rate was equivalent in the non-surgical and the surgical management groups. However, a treatment duration of
Published: 2021

18. Knee strength measurement: Can we switch between isokinetic dynamometers?

Author: Thierry Bury, Jean-Louis Croisier, Jerome Pauls, Arnaud Laly, Julien Paulus, Laurent Krecke, Jean-François Kaux, Laurent Radizzi, Caroline Le Goff, Cédric Schwartz, and Bénédicte Forthomme
Subjects: 030506 rehabilitation, Reproducibility, Dynamometer, business.industry, Biophysics, Physical Therapy, Sports Therapy and Rehabilitation, 030229 sport sciences, 03 medical and health sciences, 0302 clinical medicine, Compatibility (mechanics), Medicine, Orthopedics and Sports Medicine, 0305 other medical science, business, Biomedical engineering
Abstract: BACKGROUND: Isokinetic evaluation is considered the gold standard in muscle strength measurement due to its sensitivity, intra-dynamometer reproducibility and usefulness in the injury prevention screening and follow up of subjects with musculoskeletal pathologies, neurological disease or after surgical operation. However, can one switch among different isokinetic dynamometers for the purpose of knee muscles evaluation? OBJECTIVES: To comprehensively evaluate the compatibility of the isokinetic short concentric and eccentric strength evaluation protocol and of the fatigability resistance evaluation between three different isokinetic devices. METHODS: Eighteen recreationally active men underwent three isokinetic knee testing sessions on three different isokinetic devices with 7–10 days of rest between each session. Relative (Pearson’s r product-moment correlation coefficient – PCC) and absolute (standard error of measurement – SEM, Cohen effect sizes (d) and probabilistic inferences – MBI) parameters of reproducibility were determined to assess the inter-dynamometer agreement. RESULTS: For the short concentric and eccentric strength evaluation protocol, the extensors in concentric mode and the flexors in eccentric mode can be compared (eventually with transposition formulas provided) between Biodex, Con-Trex and Cybex (almost all PCC ⩾ 0.80). The DCR could be compared between Con-Trex and Cybex and between Biodex and Cybex pairs (eventually with transposition formula provided). For the fatigability resistance evaluation protocol, the total sum can be compared for extensors (eventually with transposition formulas provided) for PM for all dynamometer pairs considered and, in the case of MW, only for Biodex and Con-Trex (PCC ⩾ 0.80). CONCLUSIONS: Only some of the parameters derived either from the short concentric and eccentric strength evaluation protocol or the fatigability resistance evaluation protocol may be interchangeable providing transposition formulas are applied. Otherwise, isokinetic findings are largely system-dependent save some specific instances.
Published: 2021

19. Patient education improves pain and function in people with knee osteoarthritis with better effects when combined with exercise therapy: a systematic review

Author: Danilo de Oliveira Silva, A. Goff, Mark Merolli, Emily C Bell, Kay M. Crossley, and Christian J Barton
Subjects: medicine.medical_specialty, medicine.medical_treatment, MEDLINE, Psychological intervention, Physical Therapy, Sports Therapy and Rehabilitation, Osteoarthritis, RM1-950, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Quality of life, law, medicine, Knee, 030212 general & internal medicine, Rehabilitation, business.industry, Chronic pain, Patient education, medicine.disease, Physical therapy, Systematic review, Therapeutics. Pharmacology, business, 030217 neurology & neurosurgery
Abstract: Question Is patient education effective as a standalone intervention or combined with other interventions for people with knee osteoarthritis? Design Systematic review of randomised controlled trials. MEDLINE, EMBASE, SPORTDiscus, CINAHL and Web of Science were searched from inception to April 2020. The Cochrane Risk of Bias tool was used for included studies, and Grading of Recommendations, Assessment, Development and Evaluations (GRADE) was used to interpret certainty of results. Participants People with knee osteoarthritis. Intervention Any patient education intervention compared with any non-pharmacological comparator. Outcome measures Primary outcomes were self-reported pain and function. Results Twenty-nine trials involving 4,107 participants were included, informing low to very-low certainty evidence. Nineteen of 28 (68%) pooled comparisons were not statistically significant. Patient education was superior to usual care for pain (SMD −0.35, 95% CI −0.56 to −0.14) and function in the short term (−0.31, 95% CI −0.62 to 0.00), but inferior to exercise therapy for pain in the short term (0.77, 95% CI 0.07 to 1.47). Combining patient education with exercise therapy produced superior outcomes compared with patient education alone for pain in the short term (0.44, 95% CI 0.19 to 0.69) and function in the short (0.81, 95% CI 0.54 to 1.08) and medium term (0.39, 95% CI 0.15 to 0.62). When using the Western Ontario and McMaster Universities Osteoarthritis Index for these comparisons, clinically important differences indicated that patient education was inferior to exercise therapy for pain in the short term (MD 1.56, 95% CI 0.14 to 2.98) and the combination of patient education and exercise therapy for function in the short term (8.94, 95% CI 6.05 to 11.82). Conclusion Although patient education produced statistically superior short-term pain and function outcomes compared with usual care, differences were small and may not be clinically important. Patient education should not be provided as a standalone treatment and should be combined with exercise therapy to provide statistically superior and clinically important short-term improvements in function compared with education alone. Registration PROSPERO CRD42019122004.
Published: 2021

20. Navigating the COVID-19 pandemic: Initial impacts and responses of the Organ Procurement and Transplantation Network in the United States

Author: David K. Klassen, Amber R. Wilk, Maureen A. McBride, Alice E Toll, and Rebecca R. Goff
Subjects: medicine.medical_specialty, Tissue and Organ Procurement, Waiting Lists, Coronavirus disease 2019 (COVID-19), infectious disease, organ procurement and allocation, Organ transplantation, infection and infectious agents ‐ viral, Pandemic, medicine, Humans, Immunology and Allergy, organ transplantation in general, Pharmacology (medical), donors and donation: deceased, organ procurement, Pandemics, Deceased donor kidney, Transplantation, Geographic area, SARS-CoV-2, business.industry, COVID-19, Original Articles, Organ Transplantation, Organ Procurement and Transplantation Network (OPTN), ethics and public policy, Tissue Donors, United States, Organ procurement, Emergency medicine, Original Article, donors and donation: living, Living donor transplantation, business
Abstract: COVID-19 has been sweeping the globe, hitting the United States particularly hard with a state of emergency declared on March 13, 2020. Transplant hospitals have taken various precautions to protect patients from potential exposure. OPTN donor, candidate, and transplant data were analyzed from January 5, 2020 to September 5, 2020. The number of new waiting list registrations decreased, with the Northeast seeing over a 50% decrease from the week of 3/8 versus the week of 4/5. The national transplant system saw near cessation of living donor transplantation (-90%) from the week of 3/8 to the week of 4/5. Similarly, deceased donor kidney transplant volume dropped from 367 to 202 (-45%), and other organs saw similar decreases: lung (-70%), heart (-43%), and liver (-37%). Deceased donors recovered dropped from 260 to 163 (-45%) from 3/8 compared to 4/5, including a 67% decrease for lungs recovered. The magnitude of this decrease varied by geographic area, with the largest percent change (-67%) in the Northeast. Despite the pandemic, discard rates across organ has remained stable. Although the COVID-19 pandemic continues to evolve, OPTN data show recent evidence of stabilization, an indication that an early recovery of the number of living and deceased donors and transplants has ensued.
Published: 2021

21. Open data from the first and second observing runs of advanced LIGO and advanced Virgo

Author: Rich&nbsp, Abbott, Thomas&nbsp, Sheelu&nbsp, Abraham, Fausto&nbsp, Acernese, Kendall&nbsp, Ackley, Carl&nbsp, Adams, Rana&nbsp, Adhikari, Vaishali&nbsp, Adya, Christoph&nbsp, Affeldt, Michalis&nbsp, Agathos, Kazuhiro&nbsp, Agatsuma, Nancy&nbsp, Aggarwal, Odylio&nbsp, Aguiar, Amit&nbsp, Aich, Lorenzo&nbsp, Aiello, Anirban&nbsp, Ain, Ajith&nbsp, Parameswaran, Gabrielle&nbsp, Allen, Annalisa&nbsp, Allocca, Paul&nbsp, Altin, Alex&nbsp, Amato, Shreya&nbsp, Anand, Alena&nbsp, Ananyeva, Stuart&nbsp, Anderson, Warren&nbsp, Svetoslava, Angelova, Stefano&nbsp, Ansoldi, Sarah&nbsp, Antier, Stephen&nbsp, Appert, Koji&nbsp, Arai, Melody, Araya, Joseph, Areeda, Marc&nbsp, Arène, Nicolas&nbsp, Arnaud, Scott, Aronson, Arun, Kg, Ascenzi, Gregory&nbsp, Ashton, Stuart, Aston, Pia&nbsp, Astone, Florian&nbsp, Aubin, Peter&nbsp, Aufmuth, Kellie&nbsp, Aultoneal, Corey&nbsp, Austin, Valerie&nbsp, Avendano, Stanislav&nbsp, Babak, Philippe&nbsp, Bacon, Francesca&nbsp, Badaracco, Maria, Bader, Sangwook&nbsp, Bae, Anne, Baer, Jonathon&nbsp, Baird, Baldaccini, Giulio&nbsp, Ballardin, Stefan, Ballmer, Anna-marie&nbsp, Bals, Alexander&nbsp, Balsamo, Baltus, Sharan&nbsp, Banagiri, Deepak&nbsp, Bankar, Rameshwar, Bankar, Juan, Barayoga, Claudio&nbsp, Barbieri, Barry, Barish, David&nbsp, Barker, Kevin&nbsp, Barkett, Pablo&nbsp, Barneo, Fabrizio&nbsp, Barone, Bryan&nbsp, Barr, Lisa&nbsp, Barsotti, Matteo&nbsp, Barsuglia, Daniel&nbsp, Barta, Jeffrey&nbsp, Bartlett, Imre&nbsp, Bartos, Riccardo&nbsp, Bassiri, Andrea&nbsp, Basti, Mateusz&nbsp, Bawaj, Joseph, Bayley, Marco&nbsp, Bazzan, Bence&nbsp, Bécsy, Michal&nbsp, Bejger, Imene&nbsp, Belahcene, Angus, Bell, Deeksha&nbsp, Beniwal, Michael, Benjamin, Joe, Bentley, Fabio&nbsp, Bergamin, Beverly, Berger, Gerald&nbsp, Bergmann, Sebastiano&nbsp, Bernuzzi, Christopher, Berry, Diego&nbsp, Bersanetti, Alessandro&nbsp, Bertolini, Joseph&nbsp, Betzwieser, Rohan&nbsp, Bhandare, Ankit, Bhandari, Bidler, Edward&nbsp, Biggs, Igor, Bilenko, Garilynn&nbsp, Billingsley, Ross&nbsp, Birney, Ofek&nbsp, Birnholtz, Sebastien&nbsp, Biscans, Bischi, Sylvia&nbsp, Biscoveanu, Aparna&nbsp, Bisht, Guldauren&nbsp, Bissenbayeva, Massimiliano&nbsp, Bitossi, Marieanne, Bizouard, Kent, Blackburn, Jonathan&nbsp, Blackman, Carl, Blair, David, Blair, Ryan, Blair, Bobba, Nina&nbsp, Bode, Michel&nbsp, Boer, Yannick&nbsp, Boetzel, Gilles&nbsp, Bogaert, Francois&nbsp, Bondu, Edgard&nbsp, Bonilla, Romain&nbsp, Bonnand, Phillip&nbsp, Booker, Boris, Boom, Rolf&nbsp, Bork, Valerio&nbsp, Boschi, Sukanta&nbsp, Bose, Vladimir&nbsp, Bossilkov, Joel&nbsp, Bosveld, Yann&nbsp, Bouffanais, Antonella&nbsp, Bozzi, Carlo&nbsp, Bradaschia, Patrick, Brady, Alyssa&nbsp, Bramley, Marica&nbsp, Branchesi, Jim, Brau, Breschi, Tristan&nbsp, Briant, Joseph, Briggs, Francesco&nbsp, Brighenti, Alain&nbsp, Brillet, Brinkmann, Patrick&nbsp, Brockill, Aidan, Brooks, Brooks, Daniel, Brown, Sharon&nbsp, Brunett, Giacomo&nbsp, Bruno, Robert&nbsp, Bruntz, Aaron&nbsp, Buikema, Tomasz&nbsp, Bulik, Henk, Bulten, Alessandra&nbsp, Buonanno, Damir&nbsp, Buskulic, Robert, Byer, Miriam&nbsp, Cabero, Laura&nbsp, Cadonati, Giampietro&nbsp, Cagnoli, Craig&nbsp, Cahillane, Juan&nbsp, Calderón&nbsp, Bustillo, Jack, Callaghan, Thomas, Callister, Enrico&nbsp, Calloni, Jordan, Camp, Maurizio&nbsp, Canepa, Kipp, Cannon, Huy-tuong&nbsp, Cao, Junwei&nbsp, Giovanni&nbsp, Carapella, Franco&nbsp, Carbognani, Santiago&nbsp, Caride, Matthew, Carney, Gregorio&nbsp, Carullo, Julia&nbsp, Casanueva&nbsp, Diaz, Claudio&nbsp, Casentini, Javier&nbsp, Castañeda, Sarah&nbsp, Caudill, Marco&nbsp, Cavaglià, Fabien&nbsp, Cavalier, Roberto&nbsp, Cavalieri, Giancarlo&nbsp, Cella, Pablo&nbsp, Cerdá-Durán, Elisabetta&nbsp, Cesarini, Oualid&nbsp, Chaibi, Kabir&nbsp, Chakravarti, Chiwai&nbsp, Chan, Manleong&nbsp, Chan, Shiuh&nbsp, Chao, Philip&nbsp, Charlton, Eve, Chase, Eric&nbsp, Chassande-Mottin, Deep&nbsp, Chatterjee, Mayank&nbsp, Chaturvedi, Hsin-yu, Chen, Xu&nbsp, Chen, Yanbei&nbsp, Hai-ping&nbsp, Cheng, Chi-kit, Cheong, Hanyu, Chia, Chiadini, Roberto&nbsp, Chierici, Chincarini, Antonino&nbsp, Chiummo, Gihyuk&nbsp, Cho, Heesuk, Cho, Min-a&nbsp, Nelson&nbsp, Christensen, Qi&nbsp, Chu, Sheon&nbsp, Chua, Ka-wai, Chung, Shinkee&nbsp, Chung, Ciani, Pawel&nbsp, Ciecielag, Marek&nbsp, Cieślar, Alexei, Ciobanu, Ciolfi, Cipriano, Alessio&nbsp, Cirone, Filiberto&nbsp, Clara, James, Clark, Clearwater, Clesse, Frederic&nbsp, Cleva, Eugenio&nbsp, Coccia, Pierre-francois&nbsp, Cohadon, Cohen, Marta&nbsp, Colleoni, Christophe, Collette, Christopher&nbsp, Collins, Monica&nbsp, Colpi, Marcio&nbsp, Constancio&nbsp, Livia&nbsp, Jr., Conti, Sam, Cooper, Corban, Thomas, Corbitt, Isabel&nbsp, Cordero-Carrión, Silvia&nbsp, Corezzi, Kenneth, Corley, Neil&nbsp, Cornish, Corre, Corsi, Cortese, Cesar, Costa, Cotesta, Michael, Coughlin, Scott, Coughlin, Jeanpierre&nbsp, Coulon, Stefan, Countryman, Couvares, Pep, Covas, David, Coward, Matthew, Cowart, Dennis, Coyne, Coyne, Jolien, &nbsp, Creighton, Teviet, Creighton, Cripe, Michael&nbsp, Croquette, Sgwynne, Crowder, Jean-rene&nbsp, Cudell, Torrey, Cullen, Alan&nbsp, Cumming, Rebecca&nbsp, Cummings, Liam&nbsp, Cunningham, Elena&nbsp, Cuoco, Malgorzata&nbsp, Curylo, Tito&nbsp, Dal&nbsp, Canton, Gergely&nbsp, Dálya, Aykutlu&nbsp, Dana, Lara, Daneshgaran-Bajastani, Beatrice&nbsp, D’Angelo, Stefan, Danilishin, Sabrina&nbsp, D’Antonio, Karsten&nbsp, Danzmann, Christian&nbsp, Darsow-Fromm, Arnab&nbsp, Dasgupta, Laurence, &nbsp, Datrier, Vincenzo&nbsp, Dattilo, Ishant&nbsp, Dave, Michel&nbsp, Davier, Gareth, Davies, Derek&nbsp, Davis, Edward, Daw, Dan&nbsp, Debra, Malathi&nbsp, Deenadayalan, Jerome&nbsp, Degallaix, Martina&nbsp, De&nbsp, Laurentis, Samuel&nbsp, Deléglise, Matthew&nbsp, Delfavero, Nicola&nbsp, Lillo, Walter&nbsp, Del&nbsp, Pozzo, Lindsay, Demarchi, Virginia&nbsp, D’Emilio, Nicholas&nbsp, Demos, Dent, Pietri, Rosario&nbsp, Rosa, Camilla&nbsp, Rossi, Riccardo&nbsp, Desalvo, Omar&nbsp, de&nbsp, Varona, Sanjeev&nbsp, Dhurandhar, Mario, Díaz, Mauricio&nbsp, Diaz-Ortiz&nbsp, Tim&nbsp, Dietrich, Luciano&nbsp, Di&nbsp, Fiore, Chiara&nbsp, Fronzo, Cinzia&nbsp, Giorgio, Giovanni, Matteo&nbsp, Giovanni, Tristano&nbsp, Girolamo, Alberto&nbsp, Lieto, Binlei&nbsp, Ding, Sibilla&nbsp, Pace, Irene&nbsp, Palma, Renzo, Atul, Divakarla, Artemiy&nbsp, Dmitriev, Zoheyr&nbsp, Doctor, Fred&nbsp, Donovan, Katherine, Dooley, Suresh&nbsp, Doravari, Iain&nbsp, Dorrington, Thomas, Downes, Drago, Jenne, Driggers, Zhihui&nbsp, Jean-gregoire&nbsp, Ducoin, Dupej, Ofelia&nbsp, Durante, Domenico&nbsp, D’Urso, Sheila, Dwyer, Paul, Easter, Graeme&nbsp, Eddolls, Bruce&nbsp, Edelman, Tega, Edo, Oliver&nbsp, Edy, Anamaria&nbsp, Effler, Phil&nbsp, Ehrens, Johannes&nbsp, Eichholz, Stephen, Eikenberry, Eisenmann, Robert, Eisenstein, Aldo&nbsp, Ejlli, Lucianolucianikerrico&nbsp, Errico, Reed, Essick, Hector&nbsp, Estelles, Dimitri&nbsp, Estevez, Zachariah, Etienne, Todd&nbsp, Etzel, Matthew&nbsp, Evans, Tom, Evans, Rebecca, Ewing, Viviana&nbsp, Fafone, Fairhurst, Xilong&nbsp, Fan, Stefania&nbsp, Farinon, Benjamin&nbsp, Farr, Will, Farr, Edward, Fauchon-Jones, Favata, Maxime&nbsp, Fays, Mariana&nbsp, Fazio, Jon&nbsp, Feicht, Martin, Fejer, Fangchen&nbsp, Feng, Edit&nbsp, Fenyvesi, Deborah, Ferguson, Alvaro&nbsp, Fernandez-Galiana, Isidoro&nbsp, Ferrante, Elvis, Ferreira, Tabata, Ferreira, Fidecaro, Irene&nbsp, Fiori, Donatella&nbsp, Fiorucci, Maya&nbsp, Fishbach, Ryan, Fisher, Rosalba&nbsp, Fittipaldi, Margot&nbsp, Fitz-Axen, Vincenzo&nbsp, Fiumara, Raffaele&nbsp, Flaminio, Erik&nbsp, Floden, Flynn, Heather&nbsp, Fong, Antonio, Font, Perry&nbsp, Forsyth, Jean-daniel&nbsp, Fournier, Sergio&nbsp, Frasca, Frasconi, Zsolt&nbsp, Frei, Andreas&nbsp, Freise, Raymond&nbsp, Frey, Valentin&nbsp, Fritschel, Valery, Frolov, Gabriele&nbsp, Fronzè, Fulda, Fyffe, Hunter, Gabbard, Bhooshan, Gadre, Sebastian, Gaebel, Jonathan, Gair, Shanika&nbsp, Galaudage, Dhruva&nbsp, Ganapathy, Sharad, Gaonkar, Cecilio&nbsp, García-Quirós, Garufi, Bubba&nbsp, Gateley, Gaudio, Gayathri&nbsp, Gayathri, Gianluca&nbsp, Gemme, Genin, Alberto&nbsp, Gennai, George, Jogy&nbsp, Laszlo&nbsp, Gergely, Sudarshan&nbsp, Ghonge, Abhirup&nbsp, Ghosh, Archisman&nbsp, Shaon&nbsp, Bruno&nbsp, Giacomazzo, Joe, Giaime, Dwayne, Giardina, Des, Gibson, Chalisa&nbsp, Gier, Kiranjyot&nbsp, Gill, Jane&nbsp, Glanzer, Jan&nbsp, Gniesmer, Godwin, Evan&nbsp, Goetz, Ryan&nbsp, Niklas&nbsp, Gohlke, Boris&nbsp, Goncharov, Gabriela&nbsp, González, Gopakumar&nbsp, Gopakumar, Sarah, Gossan, Matthieu&nbsp, Gosselin, Gouaty, Grace, Aniello&nbsp, Grado, Massimo&nbsp, Granata, Alastair&nbsp, Grant, Slawomir&nbsp, Gras, Grassia, Gray, Rachel&nbsp, Giuseppe&nbsp, Greco, Anna, Green, Rhys&nbsp, Green, Elizabeth, Gretarsson, Hannah, Griggs, nbsp, Grignani, Grimaldi, Stefan, Grimm, Hartmut&nbsp, Grote, Steffen&nbsp, Grunewald, Pierre&nbsp, Gruning, Gianluca, Guidi, Andre, Guimaraes, Gerard&nbsp, Guixé, Hitesh, Gulati, Yuefan&nbsp, Guo, Anuradha&nbsp, Gupta, Anchal&nbsp, Pawan&nbsp, Eric, Gustafson, Dick&nbsp, Gustafson, Leila&nbsp, Haegel, Odysse&nbsp, Halim, Evan, Hall, Eleanor, Hamilton, Giles&nbsp, Hammond, Maria&nbsp, Haney, Manuela, Hanke, Hanks, Chad&nbsp, Hanna, Mark, Hannam, Otto, Hannuksela, Travis, Hansen, Joe&nbsp, Hanson, Harder, Terra&nbsp, Hardwick, Haris&nbsp, Haris, Harms, Gregg, Harry, Ian, Harry, Raine, Hasskew, Carl-johan&nbsp, Haster, Karen&nbsp, Haughian, Fergus, Hayes, James&nbsp, Healy, Antoine&nbsp, Heidmann, Matthew, Heintze, Joscha&nbsp, Heinze, Henrich&nbsp, Heitmann, Frances&nbsp, Hellman, Patrice&nbsp, Hello, Gary&nbsp, Hemming, Martin&nbsp, Hendry, Siong, Heng, Hennes, Jan-simon&nbsp, Hennig, Michele&nbsp, Heurs, Stefan&nbsp, Hild, Tanja&nbsp, Hinderer, Sarah, Hoback, Sven&nbsp, Hochheim, Elyssa&nbsp, Hofgard, Hofman, Aaron, Holgado, Nathan, Holland, Kathy&nbsp, Holt, Daniel, Holz, Hopkins, Horst, Hough, Eric, Howell, Charlie, Hoy, Yiwen&nbsp, Huang, Moritz, Hübner, Eliu, Huerta, Dominique&nbsp, Huet, Brennan&nbsp, Hughey, Victor&nbsp, Hui, Sascha&nbsp, Husa, Sabina, Huttner, Rachael&nbsp, Huxford, Tien&nbsp, Huynh-Dinh, Bartosz&nbsp, Idzkowski, Iess, Henri&nbsp, Inchauspe, Ingram, Intini, Jean, Isac, Max&nbsp, Isi, Bala, Iyer, Thibaut&nbsp, Jacqmin, Sameer, Jadhav, Shreejit, Jadhav, Alasdair, James, Karan&nbsp, Jani, Nagaraj, Janthalur, Piotr&nbsp, Jaranowski, Jariwala, Rafel&nbsp, Jaume, Alex, Jenkins, Jun&nbsp, Jiang, Grace, Johns, Aaron, Jones, Ian, Jones, Jeff, Jones, Philip&nbsp, Jones, Russell&nbsp, Reinier, &nbsp, Jonker, Ju&nbsp, Jonas&nbsp, Junker, Chinmay, Kalaghatgi, Vassiliki&nbsp, Kalogera, Brittany&nbsp, Kamai, Shivaraj&nbsp, Kandhasamy, Gungwon&nbsp, Kang, Jonah, Kanner, Shasvath, Kapadia, Karki, Rahul&nbsp, Kashyap, Marie&nbsp, Kasprzack, Wolfgang&nbsp, Kastaun, Stavros&nbsp, Katsanevas, Katsavounidis, William&nbsp, Katzman, Kaufer, Keita&nbsp, Kawabe, Fabien&nbsp, Kéfélian, Keitel, Azadeh&nbsp, Keivani, Kennedy, Joey, Key, Sudiksha&nbsp, Khadka, Farit, Khalili, Imran&nbsp, Khan, Sebastian&nbsp, Zaki, Khan, Efim, Khazanov, Nandita&nbsp, Khetan, Mohammad&nbsp, Khursheed, Nutsinee&nbsp, Kijbunchoo, Chunglee&nbsp, Kim, Grace, Kim, Jeongcho, Kim, Kyungmin&nbsp, Won&nbsp, Whansun, Kim, Young-min&nbsp, Charles&nbsp, Kimball, Peter, King, Kinley-Hanlon, Robin&nbsp, Kirchhoff, Jeffrey, Kissel, Kleybolte, Sergei&nbsp, Klimenko, Tyler, Knowles, Koch, Sina, Koehlenbeck, Gideon&nbsp, Koekoek, Soumen&nbsp, Koley, Veronica&nbsp, Kondrashov, Antonios&nbsp, Kontos, Nico&nbsp, Koper, Mikhail&nbsp, Korobko, William, Korth, Manoj&nbsp, Kovalam, Dan, Kozak, Volker&nbsp, Kringel, Krishnendu, Nv, Andrzej&nbsp, Królak, Natalie&nbsp, Krupinski, Gerrit&nbsp, Kuehn, Anil&nbsp, Kumar, Prayush&nbsp, Rakesh&nbsp, Sumit&nbsp, Ling-chi&nbsp, Kuo, Adam&nbsp, Kutynia, Benjamin, Lackey, Danny&nbsp, Laghi, Emile&nbsp, Lalande, Lam, Lam, Astrid&nbsp, Lamberts, Landry, Benjamin, Lane, Ryan, Lang, Jacob&nbsp, Lange, Brian&nbsp, Lantz, Robert, Lanza, Iuri&nbsp, La&nbsp, Rosa, Angelique&nbsp, Lartaux-Vollard, Paul, Lasky, Laxen, Albert&nbsp, Lazzarini, Claudia&nbsp, Lazzaro, Paola&nbsp, Leaci, Sean&nbsp, Leavey, Yannick, Lecoeuche, Chang-hwan, Lee, Hyung-mok, Lee, Hyungwon, Lee, Joongoo&nbsp, Lee, Kyung-ha&nbsp, Lehmann, Leroy, Letendre, Yuri&nbsp, Levin, Alvin, &nbsp, Jin&nbsp, Kaye&nbsp, Tjonnie, &nbsp, Xiang&nbsp, Frank&nbsp, Linde, Seth, Linker, Jethro, Linley, Tyson, Littenberg, Liu&nbsp, Liu, Xiaoshu&nbsp, Miquel&nbsp, Llorens-Monteagudo, Ka-lok&nbsp, Alexandra&nbsp, Lockwood, Lionel, London, Longo, Lorenzini, Vincent&nbsp, Loriette, Lormand, Losurdo, James, Lough, Carlos, Lousto, Geoffrey&nbsp, Lovelace, Harald&nbsp, Lück, Diana&nbsp, Lumaca, Andrew, Lundgren, Ma&nbsp, Yiqiu, Ronaldas&nbsp, Macas, Macfoy, Myron&nbsp, Macinnis, Duncan, Macleod, Ian, Macmillan, Adrian&nbsp, Macquet, Ignacio&nbsp, Magaña&nbsp, Hernandez, Fabian&nbsp, Magaña-Sandoval, Ryan, Magee, Ettore&nbsp, Majorana, Ivan&nbsp, Maksimovic, Asmita&nbsp, Malik, Catherine&nbsp, Man, Vuk&nbsp, Mandic, Valentina&nbsp, Mangano, Georgia, Mansell, Manske, Maddalena&nbsp, Mantovani, Michela&nbsp, Mapelli, Marchesoni, Frederique&nbsp, Marion, Szabolcs&nbsp, Márka, Zsuzsanna&nbsp, Charalampos&nbsp, Markakis, Ashot, Markosyan, Markowitz, Ed&nbsp, Maros, Antonio&nbsp, Marquina, Sylvain&nbsp, Marsat, Filippo&nbsp, Martelli, Ian, Martin, Rodica, Martin, Martinez, Denis, Martynov, Hossein&nbsp, Masalehdan, Ken&nbsp, Mason, Massera, Masserot, Thomas, Massinger, Mariela&nbsp, Masso-Reid, Simone&nbsp, Mastrogiovanni, Andrew&nbsp, Matas, Fabrice&nbsp, Matichard, Nergis&nbsp, Mavalvala, Emily&nbsp, Maynard, Joshua, Mccann, Richard&nbsp, Mccarthy, David, Mcclelland, Scott&nbsp, Mccormick, Lee&nbsp, Mcculler, Stephen, Mcguire, Connor&nbsp, Mcisaac, Jessica&nbsp, Mciver, David, Mcmanus, Terry&nbsp, Mcrae, Sean, Mcwilliams, Duncan&nbsp, Meacher, Grant, Meadors, Moritz&nbsp, Mehmet, Ajit, Mehta, Mejuto&nbsp, Villa, Andrew&nbsp, Melatos, Gregory&nbsp, Mendell, Adam, Mercer, Mereni, Kara&nbsp, Merfeld, Edmond, Merilh, Jonathan, Merritt, Mourad&nbsp, Merzougui, Syd&nbsp, Meshkov, Chris&nbsp, Messenger, Cody&nbsp, Messick, Remi&nbsp, Metzdorff, Patrick, Meyers, Fabian&nbsp, Meylahn, Ashish&nbsp, Mhaske, Miani, Haixing&nbsp, Miao, Ioannis&nbsp, Michaloliakos, Christophe&nbsp, Michel, Hannah&nbsp, Middleton, Leopoldo&nbsp, Milano, Andrewlawrence, Miller, Meg&nbsp, Millhouse, Joseph, Mills, Edoardo&nbsp, Milotti, Michael, Milovich-Goff, Olivier&nbsp, Minazzoli, Minenkov, Alec&nbsp, Mishkin, Chandra&nbsp, Mishra, Timesh&nbsp, Mistry, Sanjit&nbsp, Mitra, Valery, Mitrofanov, Guenakh&nbsp, Mitselmakher, Mittleman, Kentaro&nbsp, Mogushi, Satyanarayan, &nbsp, Mohapatra, Siddharth, Mohite, Manel&nbsp, Molina-Ruiz, Marina&nbsp, Mondin, Montani, Christopher, Moore, Moraru, Filip&nbsp, Morawski, Gerardo&nbsp, Moreno, Soichiro&nbsp, Morisaki, Benoit&nbsp, Mours, Conor, Mow-Lowry, Mozzon, Federico&nbsp, Muciaccia, Arunava&nbsp, Mukherjee, Debnandini&nbsp, Soma&nbsp, Subroto&nbsp, Nikhil&nbsp, Mukund, Mullavey, Jesper&nbsp, Munch, Erik, Muñiz, Peter, Murray, Nagar, Ilaria&nbsp, Nardecchia, Luca&nbsp, Naticchioni, Rajesh, Nayak, Benjamin, Neil, Joshua&nbsp, Neilson, Gijs&nbsp, Nelemans, Timothy, &nbsp, Nelson, Marina&nbsp, Nery, Ansel&nbsp, Neunzert, Kwan-yeung, Ng, Nguyen, Nichols, Shania, Nichols, Samaya&nbsp, Nissanke, Flavio&nbsp, Nocera, Minkyun&nbsp, Noh, North, Devon&nbsp, Nothard, Laura, Nuttall, Jason&nbsp, Oberling, Brendan, O’Brien, Gor&nbsp, Oganesyan, Greg, Ogin, John, Oh, Sanghoon, Oh, Ohme, Hiroaki&nbsp, Ohta, Marcos, Okada, Oliver, Olivetto, Oppermann, Oram, O’Reilly, Rich, Ormiston, Luis, Ortega, O’Shaughnessy, Serguei&nbsp, Ossokine, Osthelder, David, Ottaway, Harry&nbsp, Overmier, Ben, Owen, Alexander, Pace, Giulia&nbsp, Pagano, Michael, Page, Pagliaroli, Archana&nbsp, Pai, Siddhesh, Pai, Jordan, Palamos, Oleg&nbsp, Palashov, Cristiano&nbsp, Palomba, Howard&nbsp, Pan, Pratap, Panda, Tsun-ho&nbsp, Pang, Pankow, Pannarale, F, Brijesh, Pant, Paoletti, Paoli, Abhishek&nbsp, Parida, Parker, Daniela&nbsp, Pascucci, Pasqualetti, Passaquieti, Passuello, Barbara&nbsp, Patricelli, Ethan&nbsp, Payne, Brynley, Pearlstone, Thida, Pechsiri, Ari, Pedersen, Mike&nbsp, Pedraza, Arnaud&nbsp, Pele, Steven&nbsp, Penn, Albino&nbsp, Perego, Carlos, Perez, Perigois&nbsp, Périgois, Perreca, Stephane&nbsp, Perriès, Petermann, Harald, Pfeiffer, Phelps, Khun, Phukon, Ornella, Piccinni, Mikhael&nbsp, Pichot, Piendibene, Piergiovanni, Pierro, Gabriel&nbsp, Pillant, Laurent&nbsp, Pinard, Innocenzo, Pinto, Krzysztof&nbsp, Piotrzkowski, Pirello, Pitkin, Wolfango&nbsp, Plastino, Rosa&nbsp, Poggiani, Yat-tung, Pong, Ponrathnam, Pasquale&nbsp, Popolizio, Porter, Ed, Jade&nbsp, Powell, Atul, Prajapati, Kiran&nbsp, Prasai, Raghurama&nbsp, Prasanna, Geraint&nbsp, Pratten, Tanner&nbsp, Prestegard, Principe, Prodi, Leonid&nbsp, Prokhorov, Punturo, Puppo, Pürrer, Hong&nbsp, Quetschke, Pedro, Quinonez, Fred, Raab, Geert&nbsp, Raaijmakers, Hugh&nbsp, Radkins, Radulesco, Raffai, Hanna&nbsp, Rafferty, Sendhil&nbsp, Raja, Rajan&nbsp, Rajan, Binod&nbsp, Rajbhandari, Malik&nbsp, Rakhmanov, Karla, Ramirez, Antoni&nbsp, Ramos-Buades, Javed&nbsp, Rana, Kaushik&nbsp, Rao, Piero&nbsp, Rapagnani, Vivien&nbsp, Raymond, Razzano, Jocelyn&nbsp, Read, Tania&nbsp, Regimbau, Rei, Reid, David, Reitze, Rettegno, Fulvio&nbsp, Ricci, Colter, Richardson, Jonathan, Richardson, Paul, Ricker, Gunnar&nbsp, Riemenschneider, Keith&nbsp, Riles, Rizzo, Norna, Robertson, Florent&nbsp, Robinet, Rocchi, Ramon, Rodriguez-Soto, Loic&nbsp, Rolland, Jameson, Rollins, Vincent, Roma, Romanelli, Rocco&nbsp, Romano, Chandra, Romel, Isobel, Romero-Shaw, Janeen, Romie, Caitlin, Rose, Dakota&nbsp, Rose, Kyle&nbsp, Dorota&nbsp, Rosińska, Shawn, Rosofsky, Michael, Ross, Sheila&nbsp, Rowan, Samuel, Rowlinson, Palash, Roy, Santosh&nbsp, Roy, Paolo&nbsp, Ruggi, Guntis&nbsp, Rutins, Ryan, Surabhi&nbsp, Sachdev, Travis&nbsp, Sadecki, Mairi&nbsp, Sakellariadou, Salafia, Om, Livio&nbsp, Salconi, Muhammed&nbsp, Saleem, Samajdar, Eduardo, Sanchez, Luis, Sanchez, Sanchis-Gual, Jaclyn, Sanders, Kevin, Santiago, Edison&nbsp, Santos, Sarin, Sassolas, Sathyaprakash, B, Orion&nbsp, Sauter, Richard, Savage, Vaibhav&nbsp, Savant, Disha&nbsp, Sawant, Sihem&nbsp, Sayah, Dean&nbsp, Schaetzl, Schale, Mark&nbsp, Scheel, Scheuer, Patricia&nbsp, Schmidt, Roman&nbsp, Schnabel, Robert, &nbsp, Schofield, Axel&nbsp, Schönbeck, Emil&nbsp, Schreiber, Bernd, Schulte, Bernard, Schutz, Otto&nbsp, Schwarm, Eyal&nbsp, Schwartz, Jamie&nbsp, Scott, Susan, Scott, Seidel, Sellers, Anand, Sengupta, Noah&nbsp, Sennett, Sentenac, Valeria&nbsp, Sequino, Sergeev, Yoshinta&nbsp, Setyawati, Daniel, Shaddock, Shaffer, Selim, Shahriar, Sharma, Priyanka&nbsp, Shawhan, Hongyu&nbsp, Shen, Minori&nbsp, Shikauchi, Rosalie&nbsp, Shink, David, Shoemaker, Deirdre, Shoemaker, Keerti&nbsp, Shukla, Shyamsundar&nbsp, Shyamsundar, Karelle&nbsp, Siellez, Magdalena&nbsp, Sieniawska, Sigg, Leo, Singer, Divya&nbsp, Singh, Neha&nbsp, Ayatri&nbsp, Singha, Akshat&nbsp, Singhal, Alicia, Sintes, Sipala, Vasileios&nbsp, Skliris, Bram, &nbsp, Slagmolen, Teresa, Slaven-Blair, Jiri&nbsp, Smetana, Joshua, Smith, Rory, &nbsp, Smith, Surendranadh&nbsp, Somala, Edwin, Son, Siddharth&nbsp, Soni, Borja&nbsp, Sorazu, Viola&nbsp, Sordini, Fiodor&nbsp, Sorrentino, Tarun&nbsp, Souradeep, Sowell, Andrew, Spencer, Mario&nbsp, Spera, Amit, Srivastava, Varun&nbsp, Srivastava, Kai&nbsp, Staats, Cosmin&nbsp, Stachie, Standke, Daniele, Steer, Steinke, Steinlechner, Steinmeyer, Dane&nbsp, Stocks, David, Stops, Madeline&nbsp, Stover, Ken, Strain, Stratta, Amber&nbsp, Strunk, Sturani, Amber, Stuver, Sudhagar&nbsp, Sudhagar, Vivishek&nbsp, Sudhir, Tiffany, Summerscales, Ling&nbsp, Sun, Sunil&nbsp, Sunil, Ankan&nbsp, Sur, Jishnu&nbsp, Suresh, Patrick, Sutton, Bas, Swinkels, Marek, Szczepańczyk, Tacca, Simon, Tait, Colm&nbsp, Talbot, Andres, Tanasijczuk, David, Tanner, Duo&nbsp, Tao, Marton&nbsp, Tápai, Amauri&nbsp, Tapia, Enzo, Tapia&nbsp, San&nbsp, Martin, Jay, Tasson, Taylor, Rodrigo&nbsp, Tenorio, Lukas&nbsp, Terkowski, Manasadevi, Thirugnanasambandam, Thomas, Jonathan, Thompson, Sivananda, Thondapu, Keith, Thorne, Thrane, Calley, Tinsman, Saravanan, Saravanan, Shubhanshu&nbsp, Tiwari, Srishti&nbsp, Karl&nbsp, Toland, Mauro&nbsp, Tonelli, Zeno&nbsp, Tornasi, Alejandro&nbsp, Torres-Forné, Calum, Torrie, Iara&nbsp, Tosta&nbsp, e&nbsp, Melo, Töyrä, Emily, Trail, Travasso, Traylor, Maria, Tringali, Aashish&nbsp, Tripathee, Agata&nbsp, Trovato, Randy, Trudeau, Ka-wa, Tsang, Maggie&nbsp, Tse, Rhondale&nbsp, Tso, Leo&nbsp, Tsukada, Daichi&nbsp, Tsuna, Takuya&nbsp, Tsutsui, Margherita&nbsp, Turconi, Amit, Ubhi, Koh&nbsp, Ueno, Dennis&nbsp, Ugolini, Unnikrishnan, Cs, Alexander, Urban, Samantha, Usman, Andrei, Utina, Henning&nbsp, Vahlbruch, Vajente, Guillermo&nbsp, Valdes, Valentini, Vallisneri, Niels&nbsp, van&nbsp, Bakel, Martin&nbsp, Beuzekom, den&nbsp, Brand, Chris&nbsp, Van&nbsp, Den&nbsp, Broeck, Daniel, Vander-Hyde, der&nbsp, Schaaf, Joris, Van&nbsp, Heijningen, Marielle, van&nbsp, Veggel, Marco&nbsp, Vardaro, Vijay&nbsp, Varma, Steve&nbsp, Vass, Matyas&nbsp, Vasúth, Alberto&nbsp, Vecchio, Gabriele&nbsp, Vedovato, John&nbsp, Veitch, Peter, Veitch, Krishna&nbsp, Venkateswara, Gautam&nbsp, Venugopalan, Didier&nbsp, Verkindt, Doga&nbsp, Veske, Vetrano, Viceré, Aaron, Viets, Serena&nbsp, Vinciguerra, David, Vine, Jeanyves&nbsp, Vinet, Salvatore&nbsp, Vitale, Francisco&nbsp, Hernandez&nbsp, Vivanco, Thomas&nbsp, Helios&nbsp, Vocca, Cheryl&nbsp, Vorvick, Sergey, Vyatchanin, Andrew, Wade, Leslie, Wade, Wade, Rob&nbsp, Walet, Marissa&nbsp, Walker, Gavin, Wallace, Larry&nbsp, Wallace, Sinead&nbsp, Walsh, Jonathan, Wang, Sibo&nbsp, Wang, Wenhui, Wang, Yifan, Wang, Robert, Ward, Zane, Warden, Jim&nbsp, Warner, Was, Jennifer&nbsp, Watchi, Betsy&nbsp, Weaver, Li-wei&nbsp, Wei, Weinert, Alan, Weinstein, Rainer&nbsp, Weiss, Felix&nbsp, Wellmann, Linqing&nbsp, Wen, Weßels, Jonathan, Westhouse, Wette, 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(IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut des Hautes Études Scientifiques (IHES), IHES, LIGO Scientific, Virgo, (Astro)-Particles Physics, LIGO Scientific Collaboration, Virgo Collaboration, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Observatoire de la Côte d'Azur, Université Côte 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lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Fédération de recherche du Département de physique de l'Ecole Normale Supérieure - ENS Paris (FRDPENS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Spectroscopies optiques des matériaux verres, amorphes et à nanoparticules (SOPRANO), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut des Hautes Etudes Scientifiques (IHES), Agencia Estatal de Investigación (España), Generalitat de Catalunya, Generalitat Valenciana, European Commission, Grav. waves and fundamental physics, RS: FSE Grav. waves and fundamental physics, RS: FSE MSP, Abbott, R., Abbott, T. D., Abraham, S., Acernese, F., Ackley, K., Adams, C., Adhikari, R. X., Adya, V. B., Affeldt, C., Agathos, M., Agatsuma, K., Aggarwal, N., Aguiar, O. D., Aich, A., Aiello, L., Ain, A., Ajith, P., Allen, G., Allocca, A., Altin, P. A., Amato, A., Anand, S., Ananyeva, A., Anderson, S. B., Anderson, W. G., Angelova, S. V., Ansoldi, S., Antier, S., Appert, S., Arai, K., Araya, M. C., Areeda, J. S., Arène, M., Arnaud, N., Aronson, S. M., Arun, K. G., Ascenzi, S., Ashton, G., Aston, S. M., Astone, P., Aubin, F., Aufmuth, P., Aultoneal, K., Austin, C., Avendano, V., Babak, S., Bacon, P., Badaracco, F., Bader, M. K. M., Bae, S., Baer, A. M., Baird, J., Baldaccini, F., Ballardin, G., Ballmer, S. W., Bals, A., Balsamo, A., Baltus, G., Banagiri, S., Bankar, D., Bankar, R. S., Barayoga, J. C., Barbieri, C., Barish, B. C., Barker, D., Barkett, K., Barneo, P., Barone, F., Barr, B., Barsotti, L., Barsuglia, M., Barta, D., Bartlett, J., Bartos, I., Bassiri, R., Basti, A., Bawaj, M., Bayley, J. C., Bazzan, M., Bécsy, B., Bejger, M., Belahcene, I., Bell, A. S., Beniwal, D., Benjamin, M. G., Bentley, J. D., Bergamin, F., Berger, B. K., Bergmann, G., Bernuzzi, S., Berry, C. P. L., Bersanetti, D., Bertolini, A., Betzwieser, J., Bhandare, R., Bhandari, A. V., Bidler, J., Biggs, E., Bilenko, I. A., Billingsley, G., Birney, R., Birnholtz, O., Biscans, S., Bischi, M., Biscoveanu, S., Bisht, A., Bissenbayeva, G., Bitossi, M., Bizouard, M. A., Blackburn, J. K., Blackman, J., Blair, C. D., Blair, D. G., Blair, R. M., Bobba, F., Bode, N., Boer, M., Boetzel, Y., Bogaert, G., Bondu, F., Bonilla, E., Bonnand, R., Booker, P., Boom, B. A., Bork, R., Boschi, V., Bose, S., Bossilkov, V., Bosveld, J., Bouffanais, Y., Bozzi, A., Bradaschia, C., Brady, P. R., Bramley, A., Branchesi, M., Brau, J. E., Breschi, M., Briant, T., Briggs, J. H., Brighenti, F., Brillet, A., Brinkmann, M., Brockill, P., Brooks, A. F., Brooks, J., Brown, D. D., Brunett, S., Bruno, G., Bruntz, R., Buikema, A., Bulik, T., Bulten, H. J., Buonanno, A., Buskulic, D., Byer, R. L., Cabero, M., Cadonati, L., Cagnoli, G., Cahillane, C., Bustillo, J. Calderón, Callaghan, J. D., Callister, T. A., Calloni, E., Camp, J. B., Canepa, M., Cannon, K. C., Cao, H., Cao, J., Carapella, G., Carbognani, F., Caride, S., Carney, M. F., Carullo, G., Diaz, J. Casanueva, Casentini, C., Castañeda, J., Caudill, S., Cavaglià, M., Cavalier, F., Cavalieri, R., Cella, G., Cerdá-Durán, P., Cesarini, E., Chaibi, O., Chakravarti, K., Chan, C., Chan, M., Chao, S., Charlton, P., Chase, E. A., Chassande-Mottin, E., Chatterjee, D., Chaturvedi, M., Chen, H. Y., Chen, X., Chen, Y., Cheng, H. -P., Cheong, C. K., Chia, H. Y., Chiadini, F., Chierici, R., Chincarini, A., Chiummo, A., Cho, G., Cho, H. S., Cho, M., Christensen, N., Chu, Q., Chua, S., Chung, K. W., Chung, S., Ciani, G., Ciecielag, P., Cieślar, M., Ciobanu, A. A., Ciolfi, R., Cipriano, F., Cirone, A., Clara, F., Clark, J. A., Clearwater, P., Clesse, S., Cleva, F., Coccia, E., Cohadon, P. -F., Cohen, D., Colleoni, M., Collette, C. G., Collins, C., Colpi, M., Constancio, M., Conti, L., Cooper, S. J., Corban, P., Corbitt, T. R., Cordero-Carrión, I., Corezzi, S., Corley, K. R., Cornish, N., Corre, D., Corsi, A., Cortese, S., Costa, C. A., Cotesta, R., Coughlin, M. W., Coughlin, S. B., Coulon, J. -P., Countryman, S. T., Couvares, P., Covas, P. B., Coward, D. M., Cowart, M. J., Coyne, D. C., Coyne, R., Creighton, J. D. E., Creighton, T. D., Cripe, J., Croquette, M., Crowder, S. G., Cudell, J. -R., Cullen, T. J., Cumming, A., Cummings, R., Cunningham, L., Cuoco, E., Curylo, M., Canton, T. Dal, Dálya, G., Dana, A., Daneshgaran-Bajastani, L. M., D’Angelo, B., Danilishin, S. L., D’Antonio, S., Danzmann, K., Darsow-Fromm, C., Dasgupta, A., Datrier, L. E. H., Dattilo, V., Dave, I., Davier, M., Davies, G. S., Davis, D., Daw, E. J., Debra, D., Deenadayalan, M., Degallaix, J., De Laurentis, M., Deléglise, S., Delfavero, M., De Lillo, N., Del Pozzo, W., Demarchi, L. M., D’Emilio, V., Demos, N., Dent, T., De Pietri, R., De Rosa, R., De Rossi, C., Desalvo, R., de Varona, O., Dhurandhar, S., Díaz, M. C., Diaz-Ortiz, M., Dietrich, T., Di Fiore, L., Di Fronzo, C., Di Giorgio, C., Di Giovanni, F., Di Giovanni, M., Di Girolamo, T., Di Lieto, A., Ding, B., Di Pace, S., Di Palma, I., Di Renzo, F., Divakarla, A. K., Dmitriev, A., Doctor, Z., Donovan, F., Dooley, K. L., Doravari, S., Dorrington, I., Downes, T. P., Drago, M., Driggers, J. C., Du, Z., Ducoin, J. -G., Dupej, P., Durante, O., D’Urso, D., Dwyer, S. E., Easter, P. J., Eddolls, G., Edelman, B., Edo, T. B., Edy, O., Effler, A., Ehrens, P., Eichholz, J., Eikenberry, S. S., Eisenmann, M., Eisenstein, R. A., Ejlli, A., Errico, L., Essick, R. C., Estelles, H., Estevez, D., Etienne, Z. B., Etzel, T., Evans, M., Evans, T. M., Ewing, B. E., Fafone, V., Fairhurst, S., Fan, X., Farinon, S., Farr, B., Farr, W. M., Fauchon-Jones, E. J., Favata, M., Fays, M., Fazio, M., Feicht, J., Fejer, M. M., Feng, F., Fenyvesi, E., Ferguson, D. L., Fernandez-Galiana, A., Ferrante, I., Ferreira, E. C., Ferreira, T. A., Fidecaro, F., Fiori, I., Fiorucci, D., Fishbach, M., Fisher, R. P., Fittipaldi, R., Fitz-Axen, M., Fiumara, V., Flaminio, R., Floden, E., Flynn, E., Fong, H., Font, J. A., Forsyth, P. W. F., Fournier, J. -D., Frasca, S., Frasconi, F., Frei, Z., Freise, A., Frey, R., Frey, V., Fritschel, P., Frolov, V. V., Fronzè, G., Fulda, P., Fyffe, M., Gabbard, H. A., Gadre, B. U., Gaebel, S. M., Gair, J. R., Galaudage, S., Ganapathy, D., Gaonkar, S. G., García-Quirós, C., Garufi, F., Gateley, B., Gaudio, S., Gayathri, V., Gemme, G., Genin, E., Gennai, A., George, D., George, J., Gergely, L., Ghonge, S., Ghosh, Abhirup, Ghosh, Archisman, Ghosh, S., Giacomazzo, B., Giaime, J. A., Giardina, K. D., Gibson, D. R., Gier, C., Gill, K., Glanzer, J., Gniesmer, J., Godwin, P., Goetz, E., Goetz, R., Gohlke, N., Goncharov, B., González, G., Gopakumar, A., Gossan, S. E., Gosselin, M., Gouaty, R., Grace, B., Grado, A., Granata, M., Grant, A., Gras, S., Grassia, P., Gray, C., Gray, R., Greco, G., Green, A. C., Green, R., Gretarsson, E. M., Griggs, H. L., Grignani, G., Grimaldi, A., Grimm, S. J., Grote, H., Grunewald, S., Gruning, P., Guidi, G. M., Guimaraes, A. R., Guixé, G., Gulati, H. K., Guo, Y., Gupta, A., Gupta, Anchal, Gupta, P., Gustafson, E. K., Gustafson, R., Haegel, L., Halim, O., Hall, E. D., Hamilton, E. Z., Hammond, G., Haney, M., Hanke, M. M., Hanks, J., Hanna, C., Hannam, M. D., Hannuksela, O. A., Hansen, T. J., Hanson, J., Harder, T., Hardwick, T., Haris, K., Harms, J., Harry, G. M., Harry, I. W., Hasskew, R. K., Haster, C. -J., Haughian, K., Hayes, F. J., Healy, J., Heidmann, A., Heintze, M. C., Heinze, J., Heitmann, H., Hellman, F., Hello, P., Hemming, G., Hendry, M., Heng, I. S., Hennes, E., Hennig, J., Heurs, M., Hild, S., Hinderer, T., Hoback, S. Y., Hochheim, S., Hofgard, E., Hofman, D., Holgado, A. M., Holland, N. A., Holt, K., Holz, D. E., Hopkins, P., Horst, C., Hough, J., Howell, E. J., Hoy, C. G., Huang, Y., Hübner, M. T., Huerta, E. A., Huet, D., Hughey, B., Hui, V., Husa, S., Huttner, S. H., Huxford, R., Huynh-Dinh, T., Idzkowski, B., Iess, A., Inchauspe, H., Ingram, C., Intini, G., Isac, J. - M., Isi, M., Iyer, B. R., Jacqmin, T., Jadhav, S. J., Jadhav, S. P., James, A. L., Jani, K., Janthalur, N. N., Jaranowski, P., Jariwala, D., Jaume, R., Jenkins, A. C., Jiang, J., Johns, G. R., Jones, A. W., Jones, D. I., Jones, J. D., Jones, P., Jones, R., Jonker, R. J. G., Ju, L., Junker, J., Kalaghatgi, C. V., Kalogera, V., Kamai, B., Kandhasamy, S., Kang, G., Kanner, J. B., Kapadia, S. J., Karki, S., Kashyap, R., Kasprzack, M., Kastaun, W., Katsanevas, S., Katsavounidis, E., Katzman, W., Kaufer, S., Kawabe, K., Kéfélian, F., Keitel, D., Keivani, A., Kennedy, R., Key, J. S., Khadka, S., Khalili, F. Y., Khan, I., Khan, S., Khan, Z. A., Khazanov, E. A., Khetan, N., Khursheed, M., Kijbunchoo, N., Kim, Chunglee, Kim, G. J., Kim, J. C., Kim, K., Kim, W., Kim, W. S., Kim, Y. -M., Kimball, C., King, P. J., Kinley-Hanlon, M., Kirchhoff, R., Kissel, J. S., Kleybolte, L., Klimenko, S., Knowles, T. D., Koch, P., Koehlenbeck, S. M., Koekoek, G., Koley, S., Kondrashov, V., Kontos, A., Koper, N., Korobko, M., Korth, W. Z., Kovalam, M., Kozak, D. B., Kringel, V., Krishnendu, N. V., Królak, A., Krupinski, N., Kuehn, G., Kumar, A., Kumar, P., Kumar, Rahul, Kumar, Rakesh, Kumar, S., Kuo, L., Kutynia, A., Lackey, B. D., Laghi, D., Lalande, E., Lam, T. L., Lamberts, A., Landry, M., Lane, B. B., Lang, R. N., Lange, J., Lantz, B., Lanza, R. K., La Rosa, I., Lartaux-Vollard, A., Lasky, P. D., Laxen, M., Lazzarini, A., Lazzaro, C., Leaci, P., Leavey, S., Lecoeuche, Y. K., Lee, C. H., Lee, H. M., Lee, H. W., Lee, J., Lee, K., Lehmann, J., Leroy, N., Letendre, N., Levin, Y., Li, A. K. Y., Li, J., Li, K., Li, T. G. F., Li, X., Linde, F., Linker, S. D., Linley, J. N., Littenberg, T. B., Liu, J., Liu, X., Llorens-Monteagudo, M., Lo, R. K. L., Lockwood, A., London, L. T., Longo, A., Lorenzini, M., Loriette, V., Lormand, M., Losurdo, G., Lough, J. D., Lousto, C. O., Lovelace, G., Lück, H., Lumaca, D., Lundgren, A. P., Ma, Y., Macas, R., Macfoy, S., Macinnis, M., Macleod, D. M., Macmillan, I. A. O., Macquet, A., Hernandez, I. Magaña, Magaña-Sandoval, F., Magee, R. M., Majorana, E., Maksimovic, I., Malik, A., Man, N., Mandic, V., Mangano, V., Mansell, G. L., Manske, M., Mantovani, M., Mapelli, M., Marchesoni, F., Marion, F., Márka, S., Márka, Z., Markakis, C., Markosyan, A. S., Markowitz, A., Maros, E., Marquina, A., Marsat, S., Martelli, F., Martin, I. W., Martin, R. M., Martinez, V., Martynov, D. V., Masalehdan, H., Mason, K., Massera, E., Masserot, A., Massinger, T. J., Masso-Reid, M., Mastrogiovanni, S., Matas, A., Matichard, F., Mavalvala, N., Maynard, E., Mccann, J. J., Mccarthy, R., Mcclelland, D. E., Mccormick, S., Mcculler, L., Mcguire, S. C., Mcisaac, C., Mciver, J., Mcmanus, D. J., Mcrae, T., Mcwilliams, S. T., Meacher, D., Meadors, G. D., Mehmet, M., Mehta, A. K., Villa, E. Mejuto, Melatos, A., Mendell, G., Mercer, R. A., Mereni, L., Merfeld, K., Merilh, E. L., Merritt, J. D., Merzougui, M., Meshkov, S., Messenger, C., Messick, C., Metzdorff, R., Meyers, P. M., Meylahn, F., Mhaske, A., Miani, A., Miao, H., Michaloliakos, I., Michel, C., Middleton, H., Milano, L., Miller, A. L., Millhouse, M., Mills, J. C., Milotti, E., Milovich-Goff, M. C., Minazzoli, O., Minenkov, Y., Mishkin, A., Mishra, C., Mistry, T., Mitra, S., Mitrofanov, V. P., Mitselmakher, G., Mittleman, R., Mo, G., Mogushi, K., Mohapatra, S. R. P., Mohite, S. R., Molina-Ruiz, M., Mondin, M., Montani, M., Moore, C. J., Moraru, D., Morawski, F., Moreno, G., Morisaki, S., Mours, B., Mow-Lowry, C. M., Mozzon, S., Muciaccia, F., Mukherjee, Arunava, Mukherjee, D., Mukherjee, S., Mukherjee, Subroto, Mukund, N., Mullavey, A., Munch, J., Muñiz, E. A., Murray, P. G., Nagar, A., Nardecchia, I., Naticchioni, L., Nayak, R. K., Neil, B. F., Neilson, J., Nelemans, G., Nelson, T. J. N., Nery, M., Neunzert, A., Ng, K. Y., Ng, S., Nguyen, C., Nguyen, P., Nichols, D., Nichols, S. A., Nissanke, S., Nocera, F., Noh, M., North, C., Nothard, D., Nuttall, L. K., Oberling, J., O’Brien, B. D., Oganesyan, G., Ogin, G. H., Oh, J. J., Oh, S. H., Ohme, F., Ohta, H., Okada, M. A., Oliver, M., Olivetto, C., Oppermann, P., Oram, Richard J., O’Reilly, B., Ormiston, R. G., Ortega, L. F., O’Shaughnessy, R., Ossokine, S., Osthelder, C., Ottaway, D. J., Overmier, H., Owen, B. J., Pace, A. E., Pagano, G., Page, M. A., Pagliaroli, G., Pai, A., Pai, S. A., Palamos, J. R., Palashov, O., Palomba, C., Pan, H., Panda, P. K., Pang, P. T. H., Pankow, C., Pannarale, F., Pant, B. C., Paoletti, F., Paoli, A., Parida, A., Parker, W., Pascucci, D., Pasqualetti, A., Passaquieti, R., Passuello, D., Patricelli, B., Payne, E., Pearlstone, B. L., Pechsiri, T. C., Pedersen, A. J., Pedraza, M., Pele, A., Penn, S., Perego, A., Perez, C. J., Périgois, C., Perreca, A., Perriès, S., Petermann, J., Pfeiffer, H. P., Phelps, M., Phukon, K. S., Piccinni, O. J., Pichot, M., Piendibene, M., Piergiovanni, F., Pierro, V., Pillant, G., Pinard, L., Pinto, I. M., Piotrzkowski, K., Pirello, M., Pitkin, M., Plastino, W., Poggiani, R., Pong, D. Y. T., Ponrathnam, S., Popolizio, P., Porter, E. K., Powell, J., Prajapati, A. K., Prasai, K., Prasanna, R., Pratten, G., Prestegard, T., Principe, M., Prodi, G. A., Prokhorov, L., Punturo, M., Puppo, P., Pürrer, M., Qi, H., Quetschke, V., Quinonez, P. J., Raab, F. J., Raaijmakers, G., Radkins, H., Radulesco, N., Raffai, P., Rafferty, H., Raja, S., Rajan, C., Rajbhandari, B., Rakhmanov, M., Ramirez, K. E., Ramos-Buades, A., Rana, Javed, Rao, K., Rapagnani, P., Raymond, V., Razzano, M., Read, J., Regimbau, T., Rei, L., Reid, S., Reitze, D. H., Rettegno, P., Ricci, F., Richardson, C. J., Richardson, J. W., Ricker, P. M., Riemenschneider, G., Riles, K., Rizzo, M., Robertson, N. A., Robinet, F., Rocchi, A., Rodriguez-Soto, R. D., Rolland, L., Rollins, J. G., Roma, V. J., Romanelli, M., Romano, R., Romel, C. L., Romero-Shaw, I. M., Romie, J. H., Rose, C. A., Rose, D., Rose, K., Rosińska, D., Rosofsky, S. G., Ross, M. P., Rowan, S., Rowlinson, S. J., Roy, P. K., Roy, Santosh, Roy, Soumen, Ruggi, P., Rutins, G., Ryan, K., Sachdev, S., Sadecki, T., Sakellariadou, M., Salafia, O. S., Salconi, L., Saleem, M., Samajdar, A., Sanchez, E. J., Sanchez, L. E., Sanchis-Gual, N., Sanders, J. R., Santiago, K. A., Santos, E., Sarin, N., Sassolas, B., Sathyaprakash, B. S., Sauter, O., Savage, R. L., Savant, V., Sawant, D., Sayah, S., Schaetzl, D., Schale, P., Scheel, M., Scheuer, J., Schmidt, P., Schnabel, R., Schofield, R. M. S., Schönbeck, A., Schreiber, E., Schulte, B. W., Schutz, B. F., Schwarm, O., Schwartz, E., Scott, J., Scott, S. M., Seidel, E., Sellers, D., Sengupta, A. S., Sennett, N., Sentenac, D., Sequino, V., Sergeev, A., Setyawati, Y., Shaddock, D. A., Shaffer, T., Shahriar, M. S., Sharma, A., Sharma, P., Shawhan, P., Shen, H., Shikauchi, M., Shink, R., Shoemaker, D. H., Shoemaker, D. M., Shukla, K., Shyamsundar, S., Siellez, K., Sieniawska, M., Sigg, D., Singer, L. P., Singh, D., Singh, N., Singha, A., Singhal, A., Sintes, A. M., Sipala, V., Skliris, V., Slagmolen, B. J. J., Slaven-Blair, T. J., Smetana, J., Smith, J. R., Smith, R. J. E., Somala, S., Son, E. J., Soni, S., Sorazu, B., Sordini, V., Sorrentino, F., Souradeep, T., Sowell, E., Spencer, A. P., Spera, M., Srivastava, A. K., Srivastava, V., Staats, K., Stachie, C., Standke, M., Steer, D. A., Steinke, M., Steinlechner, J., Steinlechner, S., Steinmeyer, D., Stocks, D., Stops, D. J., Stover, M., Strain, K. A., Stratta, G., Strunk, A., Sturani, R., Stuver, A. L., Sudhagar, S., Sudhir, V., Summerscales, T. Z., Sun, L., Sunil, S., Sur, A., Suresh, J., Sutton, P. J., Swinkels, B. L., Szczepańczyk, M. J., Tacca, M., Tait, S. C., Talbot, C., Tanasijczuk, A. J., Tanner, D. B., Tao, D., Tápai, M., Tapia, A., Martin, E. N. Tapia San, Tasson, J. D., Taylor, R., Tenorio, R., Terkowski, L., Thirugnanasambandam, M. P., Thomas, M., Thomas, P., Thompson, J. E., Thondapu, S. R., Thorne, K. A., Thrane, E., Tinsman, C. L., Saravanan, T. R., Tiwari, Shubhanshu, Tiwari, S., Tiwari, V., Toland, K., Tonelli, M., Tornasi, Z., Torres-Forné, A., Torrie, C. I., Tosta e Melo, I., Töyrä, D., Trail, E. A., Travasso, F., Traylor, G., Tringali, M. C., Tripathee, A., Trovato, A., Trudeau, R. J., Tsang, K. W., Tse, M., Tso, R., Tsukada, L., Tsuna, D., Tsutsui, T., Turconi, M., Ubhi, A. S., Ueno, K., Ugolini, D., Unnikrishnan, C. S., Urban, A. L., Usman, S. A., Utina, A. C., Vahlbruch, H., Vajente, G., Valdes, G., Valentini, M., Vallisneri, M., van Bakel, N., van Beuzekom, M., van den Brand, J. F. J., Van Den Broeck, C., Vander-Hyde, D. C., van der Schaaf, L., Van Heijningen, J. V., van Veggel, A. A., Vardaro, M., Varma, V., Vass, S., Vasúth, M., Vecchio, A., Vedovato, G., Veitch, J., Veitch, P. J., Venkateswara, K., Venugopalan, G., Verkindt, D., Veske, D., Vetrano, F., Viceré, A., Viets, A. D., Vinciguerra, S., Vine, D. J., Vinet, J. -Y., Vitale, S., Vivanco, Francisco Hernandez, Vo, T., Vocca, H., Vorvick, C., Vyatchanin, S. P., Wade, A. R., Wade, L. E., Wade, M., Walet, R., Walker, M., Wallace, G. S., Wallace, L., Walsh, S., Wang, J. Z., Wang, S., Wang, W. H., Wang, Y. F., Ward, R. L., Warden, Z. A., Warner, J., Was, M., Watchi, J., Weaver, B., Wei, L. -W., Weinert, M., Weinstein, A. J., Weiss, R., Wellmann, F., Wen, L., Weßels, P., Westhouse, J. W., Wette, K., Whelan, J. T., Whiting, B. F., Whittle, C., Wilken, D. M., Williams, D., Williams, R. D., Williamson, A. R., Willis, J. L., Willke, B., Winkler, W., Wipf, C. C., Wittel, H., Woan, G., Woehler, J., Wofford, J. K., Wong, C., Wright, J. L., Wu, D. S., Wysocki, D. M., Xiao, L., Yamamoto, H., Yang, L., Yang, Y., Yang, Z., Yap, M. J., Yazback, M., Yeeles, D. W., Yu, Hang, Yu, Haocun, Yuen, S. H. R., Zadrożny, A. K., Zadrożny, A., Zanolin, M., Zelenova, T., Zendri, J. -P., Zevin, M., Zhang, J., Zhang, L., Zhang, T., Zhao, C., Zhao, G., Zhou, M., Zhou, Z., Zhu, X. J., Zimmerman, A. B., Zucker, M. E., Zweizig, J., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université Nice Sophia Antipolis (... - 2019) (UNS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-École Nationale Supérieure des Sciences Appliquées et de Technologie (ENSSAT)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Collège de France (CdF (institution)), Abbott, R, Abbott, T, Abraham, S, Acernese, F, Ackley, K, Adams, C, Adhikari, R, Adya, V, Affeldt, C, Agathos, M, Agatsuma, K, Aggarwal, N, Aguiar, O, Aich, A, Aiello, L, Ain, A, Ajith, P, Allen, G, Allocca, A, Altin, P, Amato, A, Anand, S, Ananyeva, A, Anderson, S, Anderson, W, Angelova, S, Ansoldi, S, Antier, S, Appert, S, Arai, K, Araya, M, Areeda, J, Arene, M, Arnaud, N, Aronson, S, Arun, K, Ascenzi, S, Ashton, G, Aston, S, Astone, P, Aubin, F, Aufmuth, P, Aultoneal, K, Austin, C, Avendano, V, Babak, S, Bacon, P, Badaracco, F, Bader, M, Bae, S, Baer, A, Baird, J, Baldaccini, F, Ballardin, G, Ballmer, S, Bals, A, Balsamo, A, Baltus, G, Banagiri, S, Bankar, D, Bankar, R, Barayoga, J, Barbieri, C, Barish, B, Barker, D, Barkett, K, Barneo, P, Barone, F, Barr, B, Barsotti, L, Barsuglia, M, Barta, D, Bartlett, J, Bartos, I, Bassiri, R, Basti, A, Bawaj, M, Bayley, J, Bazzan, M, Becsy, B, Bejger, M, Belahcene, I, Bell, A, Beniwal, D, Benjamin, M, Bentley, J, Bergamin, F, Berger, B, Bergmann, G, Bernuzzi, S, Berry, C, Bersanetti, D, Bertolini, A, Betzwieser, J, Bhandare, R, Bhandari, A, Bidler, J, Biggs, E, Bilenko, I, Billingsley, G, Birney, R, Birnholtz, O, Biscans, S, Bischi, M, Biscoveanu, S, Bisht, A, Bissenbayeva, G, Bitossi, M, Bizouard, M, Blackburn, J, Blackman, J, Blair, C, Blair, D, Blair, R, Bobba, F, Bode, N, Boer, M, Boetzel, Y, Bogaert, G, Bondu, F, Bonilla, E, Bonnand, R, Booker, P, Boom, B, Bork, R, Boschi, V, Bose, S, Bossilkov, V, Bosveld, J, Bouffanais, Y, Bozzi, A, Bradaschia, C, Brady, P, Bramley, A, Branchesi, M, Brau, J, Breschi, M, Briant, T, Briggs, J, Brighenti, F, Brillet, A, Brinkmann, M, Brockill, P, Brooks, A, Brooks, J, Brown, D, Brunett, S, Bruno, G, Bruntz, R, Buikema, A, Bulik, T, Bulten, H, Buonanno, A, Buskulic, D, Byer, R, Cabero, M, Cadonati, L, Cagnoli, G, Cahillane, C, Bustillo, J, Callaghan, J, Callister, T, Calloni, E, Camp, J, Canepa, M, Cannon, K, Cao, H, Cao, J, Carapella, G, Carbognani, F, Caride, S, Carney, M, Carullo, G, Diaz, J, Casentini, C, Castaneda, J, Caudill, S, Cavaglia, M, Cavalier, F, Cavalieri, R, Cella, G, Cerda-Duran, P, Cesarini, E, Chaibi, O, Chakravarti, K, Chan, C, Chan, M, Chao, S, Charlton, P, Chase, E, Chassande-Mottin, E, Chatterjee, D, Chaturvedi, M, Chen, H, Chen, X, Chen, Y, Cheng, H, Cheong, C, Chia, H, Chiadini, F, Chierici, R, Chincarini, A, Chiummo, A, Cho, G, Cho, H, Cho, M, Christensen, N, Chu, Q, Chua, S, Chung, K, Chung, S, Ciani, G, Ciecielag, P, Cieslar, M, Ciobanu, A, Ciolfi, R, Cipriano, F, Cirone, A, Clara, F, Clark, J, Clearwater, P, Clesse, S, Cleva, F, Coccia, E, Cohadon, P, Cohen, D, Colleoni, M, Collette, C, Collins, C, Colpi, M, Constancio, M, Conti, L, Cooper, S, Corban, P, Corbitt, T, Cordero-Carrion, I, Corezzi, S, Corley, K, Cornish, N, Corre, D, Corsi, A, Cortese, S, Costa, C, Cotesta, R, Coughlin, M, Coughlin, S, Coulon, J, Countryman, S, Couvares, P, Covas, P, Coward, D, Cowart, M, Coyne, D, Coyne, R, Creighton, J, Creighton, T, Cripe, J, Croquette, M, Crowder, S, Cudell, J, Cullen, T, Cumming, A, Cummings, R, Cunningham, L, Cuoco, E, Curylo, M, Canton, T, Dalya, G, Dana, A, Daneshgaran-Bajastani, L, D'Angelo, B, Danilishin, S, D'Antonio, S, Danzmann, K, Darsow-Fromm, C, Dasgupta, A, Datrier, L, Dattilo, V, Dave, I, Davier, M, Davies, G, Davis, D, Daw, E, Debra, D, Deenadayalan, M, Degallaix, J, De Laurentis, M, Deleglise, S, Delfavero, M, De Lillo, N, Del Pozzo, W, Demarchi, L, D'Emilio, V, Demos, N, Dent, T, De Pietri, R, De Rosa, R, De Rossi, C, Desalvo, R, de Varona, O, Dhurandhar, S, Diaz, M, Diaz-Ortiz, M, Dietrich, T, Di Fiore, L, Di Fronzo, C, Di Giorgio, C, Di Giovanni, F, Di Giovanni, M, Di Girolamo, T, Di Lieto, A, Ding, B, Di Pace, S, Di Palma, I, Di Renzo, F, Divakarla, A, Dmitriev, A, Doctor, Z, Donovan, F, Dooley, K, Doravari, S, Dorrington, I, Downes, T, Drago, M, Driggers, J, Du, Z, Ducoin, J, Dupej, P, Durante, O, D'Urso, D, Dwyer, S, Easter, P, Eddolls, G, Edelman, B, Edo, T, Edy, O, Effler, A, Ehrens, P, Eichholz, J, Eikenberry, S, Eisenmann, M, Eisenstein, R, Ejlli, A, Errico, L, Essick, R, Estelles, H, Estevez, D, Etienne, Z, Etzel, T, Evans, M, Evans, T, Ewing, B, Fafone, V, Fairhurst, S, Fan, X, Farinon, S, Farr, B, Farr, W, Fauchon-Jones, E, Favata, M, Fays, M, Fazio, M, Feicht, J, Fejer, M, Feng, F, Fenyvesi, E, Ferguson, D, Fernandez-Galiana, A, Ferrante, I, Ferreira, E, Ferreira, T, Fidecaro, F, Fiori, I, Fiorucci, D, Fishbach, M, Fisher, R, Fittipaldi, R, Fitz-Axen, M, Fiumara, V, Flaminio, R, Floden, E, Flynn, E, Fong, H, Font, J, Forsyth, P, Fournier, J, Frasca, S, Frasconi, F, Frei, Z, Freise, A, Frey, R, Frey, V, Fritschel, P, Frolov, V, Fronze, G, Fulda, P, Fyffe, M, Gabbard, H, Gadre, B, Gaebel, S, Gair, J, Galaudage, S, Ganapathy, D, Gaonkar, S, Garcia-Quiros, C, Garufi, F, Gateley, B, Gaudio, S, Gayathri, V, Gemme, G, Genin, E, Gennai, A, George, D, George, J, Gergely, L, Ghonge, S, Ghosh, A, Ghosh, S, Giacomazzo, B, Giaime, J, Giardina, K, Gibson, D, Gier, C, Gill, K, Glanzer, J, Gniesmer, J, Godwin, P, Goetz, E, Goetz, R, Gohlke, N, Goncharov, B, Gonzalez, G, Gopakumar, A, Gossan, S, Gosselin, M, Gouaty, R, Grace, B, Grado, A, Granata, M, Grant, A, Gras, S, Grassia, P, Gray, C, Gray, R, Greco, G, Green, A, Green, R, Gretarsson, E, Griggs, H, Grignani, G, Grimaldi, A, Grimm, S, Grote, H, Grunewald, S, Gruning, P, Guidi, G, Guimaraes, A, Guixe, G, Gulati, H, Guo, Y, Gupta, A, Gupta, P, Gustafson, E, Gustafson, R, Haegel, L, Halim, O, Hall, E, Hamilton, E, Hammond, G, Haney, M, Hanke, M, Hanks, J, Hanna, C, Hannam, M, Hannuksela, O, Hansen, T, Hanson, J, Harder, T, Hardwick, T, Haris, K, Harms, J, Harry, G, Harry, I, Hasskew, R, Haster, C, Haughian, K, Hayes, F, Healy, J, Heidmann, A, Heintze, M, Heinze, J, Heitmann, H, Hellman, F, Hello, P, Hemming, G, Hendry, M, Heng, I, Hennes, E, Hennig, J, Heurs, M, Hild, S, Hinderer, T, Hoback, S, Hochheim, S, Hofgard, E, Hofman, D, Holgado, A, Holland, N, Holt, K, Holz, D, Hopkins, P, Horst, C, Hough, J, Howell, E, Hoy, C, Huang, Y, Hubner, M, Huerta, E, Huet, D, Hughey, B, Hui, V, Husa, S, Huttner, S, Huxford, R, Huynh-Dinh, T, Idzkowski, B, Iess, A, Inchauspe, H, Ingram, C, Intini, G, Isac, J, Isi, M, Iyer, B, Jacqmin, T, Jadhav, S, James, A, Jani, K, Janthalur, N, Jaranowski, P, Jariwala, D, Jaume, R, Jenkins, A, Jiang, J, Johns, G, Jones, A, Jones, D, Jones, J, Jones, P, Jones, R, Jonker, R, Ju, L, Junker, J, Kalaghatgi, C, Kalogera, V, Kamai, B, Kandhasamy, S, Kang, G, Kanner, J, Kapadia, S, Karki, S, Kashyap, R, Kasprzack, M, Kastaun, W, Katsanevas, S, Katsavounidis, E, Katzman, W, Kaufer, S, Kawabe, K, Kefelian, F, Keitel, D, Keivani, A, Kennedy, R, Key, J, Khadka, S, Khalili, F, Khan, I, Khan, S, Khan, Z, Khazanov, E, Khetan, N, Khursheed, M, Kijbunchoo, N, Kim, C, Kim, G, Kim, J, Kim, K, Kim, W, Kim, Y, Kimball, C, King, P, Kinley-Hanlon, M, Kirchhoff, R, Kissel, J, Kleybolte, L, Klimenko, S, Knowles, T, Koch, P, Koehlenbeck, S, Koekoek, G, Koley, S, Kondrashov, V, Kontos, A, Koper, N, Korobko, M, Korth, W, Kovalam, M, Kozak, D, Kringel, V, Krishnendu, N, Krolak, A, Krupinski, N, Kuehn, G, Kumar, A, Kumar, P, Kumar, R, Kumar, S, Kuo, L, Kutynia, A, Lackey, B, Laghi, D, Lalande, E, Lam, T, Lamberts, A, Landry, M, Lane, B, Lang, R, Lange, J, Lantz, B, Lanza, R, La Rosa, I, Lartaux-Vollard, A, Lasky, P, Laxen, M, Lazzarini, A, Lazzaro, C, Leaci, P, Leavey, S, Lecoeuche, Y, Lee, C, Lee, H, Lee, J, Lee, K, Lehmann, J, Leroy, N, Letendre, N, Levin, Y, Li, A, Li, J, Li, K, Li, T, Li, X, Linde, F, Linker, S, Linley, J, Littenberg, T, Liu, J, Liu, X, Llorens-Monteagudo, M, Lo, R, Lockwood, A, London, L, Longo, A, Lorenzini, M, Loriette, V, Lormand, M, Losurdo, G, Lough, J, Lousto, C, Lovelace, G, Luck, H, Lumaca, D, Lundgren, A, Ma, Y, Macas, R, Macfoy, S, Macinnis, M, Macleod, D, Macmillan, I, Macquet, A, Hernandez, I, Magana-Sandoval, F, Magee, R, Majorana, E, Maksimovic, I, Malik, A, Man, N, Mandic, V, Mangano, V, Mansell, G, Manske, M, Mantovani, M, Mapelli, M, Marchesoni, F, Marion, F, Marka, S, Marka, Z, Markakis, C, Markosyan, A, Markowitz, A, Maros, E, Marquina, A, Marsat, S, Martelli, F, Martin, I, Martin, R, Martinez, V, Martynov, D, Masalehdan, H, Mason, K, Massera, E, Masserot, A, Massinger, T, Masso-Reid, M, Mastrogiovanni, S, Matas, A, Matichard, F, Mavalvala, N, Maynard, E, Mccann, J, Mccarthy, R, Mcclelland, D, Mccormick, S, Mcculler, L, Mcguire, S, Mcisaac, C, Mciver, J, Mcmanus, D, Mcrae, T, Mcwilliams, S, Meacher, D, Meadors, G, Mehmet, M, Mehta, A, Villa, E, Melatos, A, Mendell, G, Mercer, R, Mereni, L, Merfeld, K, Merilh, E, Merritt, J, Merzougui, M, Meshkov, S, Messenger, C, Messick, C, Metzdorff, R, Meyers, P, Meylahn, F, Mhaske, A, Miani, A, Miao, H, Michaloliakos, I, Michel, C, Middleton, H, Milano, L, Miller, A, Millhouse, M, Mills, J, Milotti, E, Milovich-Goff, M, Minazzoli, O, Minenkov, Y, Mishkin, A, Mishra, C, Mistry, T, Mitra, S, Mitrofanov, V, Mitselmakher, G, Mittleman, R, Mo, G, Mogushi, K, Mohapatra, S, Mohite, S, Molina-Ruiz, M, Mondin, M, Montani, M, Moore, C, Moraru, D, Morawski, F, Moreno, G, Morisaki, S, Mours, B, Mow-Lowry, C, Mozzon, S, Muciaccia, F, Mukherjee, A, Mukherjee, D, Mukherjee, S, Mukund, N, Mullavey, A, Munch, J, Muniz, E, Murray, P, Nagar, A, Nardecchia, I, Naticchioni, L, Nayak, R, Neil, B, Neilson, J, Nelemans, G, Nelson, T, Nery, M, Neunzert, A, Ng, K, Ng, S, Nguyen, C, Nguyen, P, Nichols, D, Nichols, S, Nissanke, S, Nocera, F, Noh, M, North, C, Nothard, D, Nuttall, L, Oberling, J, O'Brien, B, Oganesyan, G, Ogin, G, Oh, J, Oh, S, Ohme, F, Ohta, H, Okada, M, Oliver, M, Olivetto, C, Oppermann, P, Oram, R, O'Reilly, B, Ormiston, R, Ortega, L, O'Shaughnessy, R, Ossokine, S, Osthelder, C, Ottaway, D, Overmier, H, Owen, B, Pace, A, Pagano, G, Page, M, Pagliaroli, G, Pai, A, Pai, S, Palamos, J, Palashov, O, Palomba, C, Pan, H, Panda, P, Pang, P, Pankow, C, Pannarale, F, Pant, B, Paoletti, F, Paoli, A, Parida, A, Parker, W, Pascucci, D, Pasqualetti, A, Passaquieti, R, Passuello, D, Patricelli, B, Payne, E, Pearlstone, B, Pechsiri, T, Pedersen, A, Pedraza, M, Pele, A, Penn, S, Perego, A, Perez, C, Perigois, C, Perreca, A, Perries, S, Petermann, J, Pfeiffer, H, Phelps, M, Phukon, K, Piccinni, O, Pichot, M, Piendibene, M, Piergiovanni, F, Pierro, V, Pillant, G, Pinard, L, Pinto, I, Piotrzkowski, K, Pirello, M, Pitkin, M, Plastino, W, Poggiani, R, Pong, D, Ponrathnam, S, Popolizio, P, Porter, E, Powell, J, Prajapati, A, Prasai, K, Prasanna, R, Pratten, G, Prestegard, T, Principe, M, Prodi, G, Prokhorov, L, Punturo, M, Puppo, P, Purrer, M, Qi, H, Quetschke, V, Quinonez, P, Raab, F, Raaijmakers, G, Radkins, H, Radulesco, N, Raffai, P, Rafferty, H, Raja, S, Rajan, C, Rajbhandari, B, Rakhmanov, M, Ramirez, K, Ramos-Buades, A, Rana, J, Rao, K, Rapagnani, P, Raymond, V, Razzano, M, Read, J, Regimbau, T, Rei, L, Reid, S, Reitze, D, Rettegno, P, Ricci, F, Richardson, C, Richardson, J, Ricker, P, Riemenschneider, G, Riles, K, Rizzo, M, Robertson, N, Robinet, F, Rocchi, A, Rodriguez-Soto, R, Rolland, L, Rollins, J, Roma, V, Romanelli, M, Romano, R, Romel, C, Romero-Shaw, I, Romie, J, Rose, C, Rose, D, Rose, K, Rosinska, D, Rosofsky, S, Ross, M, Rowan, S, Rowlinson, S, Roy, P, Roy, S, Ruggi, P, Rutins, G, Ryan, K, Sachdev, S, Sadecki, T, Sakellariadou, M, Salafia, O, Salconi, L, Saleem, M, Samajdar, A, Sanchez, E, Sanchez, L, Sanchis-Gual, N, Sanders, J, Santiago, K, Santos, E, Sarin, N, Sassolas, B, Sathyaprakash, B, Sauter, O, Savage, R, Savant, V, Sawant, D, Sayah, S, Schaetzl, D, Schale, P, Scheel, M, Scheuer, J, Schmidt, P, Schnabel, R, Schofield, R, Schonbeck, A, Schreiber, E, Schulte, B, Schutz, B, Schwarm, O, Schwartz, E, Scott, J, Scott, S, Seidel, E, Sellers, D, Sengupta, A, Sennett, N, Sentenac, D, Sequino, V, Sergeev, A, Setyawati, Y, Shaddock, D, Shaffer, T, Shahriar, M, Sharma, A, Sharma, P, Shawhan, P, Shen, H, Shikauchi, M, Shink, R, Shoemaker, D, Shukla, K, Shyamsundar, S, Siellez, K, Sieniawska, M, Sigg, D, Singer, L, Singh, D, Singh, N, Singha, A, Singhal, A, Sintes, A, Sipala, V, Skliris, V, Slagmolen, B, Slaven-Blair, T, Smetana, J, Smith, J, Smith, R, Somala, S, Son, E, Soni, S, Sorazu, B, Sordini, V, Sorrentino, F, Souradeep, T, Sowell, E, Spencer, A, Spera, M, Srivastava, A, Srivastava, V, Staats, K, Stachie, C, Standke, M, Steer, D, Steinke, M, Steinlechner, J, Steinlechner, S, Steinmeyer, D, Stocks, D, Stops, D, Stover, M, Strain, K, Stratta, G, Strunk, A, Sturani, R, Stuver, A, Sudhagar, S, Sudhir, V, Summerscales, T, Sun, L, Sunil, S, Sur, A, Suresh, J, Sutton, P, Swinkels, B, Szczepanczyk, M, Tacca, M, Tait, S, Talbot, C, Tanasijczuk, A, Tanner, D, Tao, D, Tapai, M, Tapia, A, Martin, E, Tasson, J, Taylor, R, Tenorio, R, Terkowski, L, Thirugnanasambandam, M, Thomas, M, Thomas, P, Thompson, J, Thondapu, S, Thorne, K, Thrane, E, Tinsman, C, Saravanan, T, Tiwari, S, Tiwari, V, Toland, K, Tonelli, M, Tornasi, Z, Torres-Forne, A, Torrie, C, Tosta e Melo, I, Toyra, D, Trail, E, Travasso, F, Traylor, G, Tringali, M, Tripathee, A, Trovato, A, Trudeau, R, Tsang, K, Tse, M, Tso, R, Tsukada, L, Tsuna, D, Tsutsui, T, Turconi, M, Ubhi, A, Ueno, K, Ugolini, D, Unnikrishnan, C, Urban, A, Usman, S, Utina, A, Vahlbruch, H, Vajente, G, Valdes, G, Valentini, M, Vallisneri, M, van Bakel, N, van Beuzekom, M, van den Brand, J, Van Den Broeck, C, Vander-Hyde, D, van der Schaaf, L, Van Heijningen, J, van Veggel, A, Vardaro, M, Varma, V, Vass, S, Vasuth, M, Vecchio, A, Vedovato, G, Veitch, J, Veitch, P, Venkateswara, K, Venugopalan, G, Verkindt, D, Veske, D, Vetrano, F, Vicere, A, Viets, A, Vinciguerra, S, Vine, D, Vinet, J, Vitale, S, Vivanco, F, Vo, T, Vocca, H, Vorvick, C, Vyatchanin, S, Wade, A, Wade, L, Wade, M, Walet, R, Walker, M, Wallace, G, Wallace, L, Walsh, S, Wang, J, Wang, S, Wang, W, Wang, Y, Ward, R, Warden, Z, Warner, J, Was, M, Watchi, J, Weaver, B, Wei, L, Weinert, M, Weinstein, A, Weiss, R, Wellmann, F, Wen, L, Wessels, P, Westhouse, J, Wette, K, Whelan, J, Whiting, B, Whittle, C, Wilken, D, Williams, D, Williams, R, Williamson, A, Willis, J, Willke, B, Winkler, W, Wipf, C, Wittel, H, Woan, G, Woehler, J, Wofford, J, Wong, C, Wright, J, Wu, D, Wysocki, D, Xiao, L, Yamamoto, H, Yang, L, Yang, Y, Yang, Z, Yap, M, Yazback, M, Yeeles, D, Yu, H, Yuen, S, Zadrozny, A, Zanolin, M, Zelenova, T, Zendri, J, Zevin, M, Zhang, J, Zhang, L, Zhang, T, Zhao, C, Zhao, G, Zhou, M, Zhou, Z, Zhu, X, Zimmerman, A, Zucker, M, Zweizig, J, IoP (FNWI), Faculty of Science, Gravitation and Astroparticle Physics Amsterdam, Other Research IHEF (IoP, FNWI), Astroparticle Physics (IHEF, IoP, FNWI), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), The LIGO Scientific Collaboration, The Virgo Collaboration, Arene, M., Becsy, B., Bustillo, J. C., Diaz, J. C., Castaneda, J., Cavaglia, M., Cerda-Duran, P., Cieslar, M., Cordero-Carrion, I., Canton, T. D., Dalya, G., D'Angelo, B., D'Antonio, S., Deleglise, S., D'Emilio, V., Diaz, M. C., D'Urso, D., Fronze, G., Garcia-Quiros, C., Ghosh, A., Gonzalez, G., Guixe, G., Hubner, M. T., Isac, J. -M., Kefelian, F., Kim, C., Krolak, A., Kumar, R., Luck, H., Hernandez, I. M., Magana-Sandoval, F., Marka, S., Marka, Z., Villa, E. M., Mukherjee, A., Muniz, E. A., O'Brien, B. D., Oram, R. J., O'Reilly, B., O'Shaughnessy, R., Perigois, C., Perries, S., Pinto, I., Purrer, M., Rana, J., Rosinska, D., Roy, S., Schonbeck, A., Szczepanczyk, M. J., Tapai, M., Martin, E. N. T. S., Torres-Forne, A., Toyra, D., Vasuth, M., Vicere, A., Vivanco, F. H., Wessels, P., Yu, H., Zadrozny, A. K., and Zadrozny, A.
Subjects: Technology, Gravitational Waves, Open Data, O1, O2, LIGO, Virgo, Astronomy, Strain measurement, Gravitational Wave, open data, Data representation and management, Gravitational Waves, GWOSC, Scientific databases, gravitational waves, 01 natural sciences, General Relativity and Quantum Cosmology, Software, Documentation, DESIGN, Open Data, Computer software, Data products, LIGO, QC, 12-AXIS VIBRATION ISOLATION, media_common, Settore FIS/01, 0303 health sciences, Gravitational effects, BINARY MERGERS, Computer Science Applications, Open data, [PHYS.GRQC]Physics [physics]/General Relativity and Quantum Cosmology [gr-qc], Open science, Astrophysics - Instrumentation and Methods for Astrophysics, data analysis method, gr-qc, media_common.quotation_subject, Real-time computing, FOS: Physical sciences, O2, PUBLIC ADVANCED LIGO, General Relativity and Quantum Cosmology (gr-qc), Gravity waves, programming, O1, 03 medical and health sciences, QA76.75-76.765, Dewey Decimal Classification::000 | Allgemeines, Wissenschaft::000 | Informatik, Wissen, Systeme::004 | Informatik, SDG 17 - Partnerships for the Goals, GWOSC, Scientific databases, Data representation and management, Gravitational Waves, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, GRAVITATIONAL-WAVE CATALOG, Instrumentation and Methods for Astrophysics (astro-ph.IM), STFC, Astrophysique, 030304 developmental biology, Science & Technology, business.industry, Gravitational wave, Virgo, gravitational radiation, RCUK, Strain data, Data-quality information, Computer Science, Software Engineering, gravitational radiation detector, detector: sensitivity, Scientific database, monitoring, VIRGO, Sky, gravitational radiation: emission, Computer Science, ddc:004, business, astro-ph.IM
Abstract: Abbot, Rich, et al. (Virgo and MAGIC Collaboration), Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software., The authors gratefully acknowledge the support of the United States National Science Foundation (NSF) for the construction and operation of the LIGO Laboratory and Advanced LIGO as well as the Science and Technology Facilities Council (STFC) of the United Kingdom, the Max-Planck-Society (MPS), and the State of Niedersachsen/Germany for support of the construction of Advanced LIGO and construction and operation of the GEO600 detector. Additional support for Advanced LIGO was provided by the Australian Research Council. The authors gratefully acknowledge the Italian Istituto Nazionale di Fisica Nucleare (INFN), the French Centre National de la Recherche Scientifique (CNRS) and the Foundation for Fundamental Research on Matter supported by the Netherlands Organisation for Scientific Research, for the construction and operation of the Virgo detector and the creation and support of the EGO consortium. The authors also gratefully acknowledge research support from these agencies as well as by the Council of Scientific and Industrial Research of India, the Department of Science and Technology, India, the Science & Engineering Research Board (SERB), India, the Ministry of Human Resource Development, India, the Spanish Agencia Estatal de Investigación, the Vicepresidència i Conselleria d’Innovació, Recerca i Turisme and the Conselleria d’Educació i Universitat del Govern de les Illes Balears, the Conselleria d’Educació, Investigació, Cultura i Esport de la Generalitat Valenciana, the National Science Centre of Poland, the Swiss National Science Foundation (SNSF), the Russian Foundation for Basic Research, the Russian Science Foundation, the European Commission, the European Regional Development Funds (ERDF), the Royal Society, the Scottish Funding Council, the Scottish Universities Physics Alliance, the Hungarian Scientific Research Fund (OTKA), the Lyon Institute of Origins (LIO), the Paris Île-de-France Region, the National Research, Development and Innovation Office Hungary (NKFIH), the National Research Foundation of Korea, Industry Canada and the Province of Ontario through the Ministry of Economic Development and Innovation, the Natural Science and Engineering Research Council Canada, the Canadian Institute for Advanced Research, the Brazilian Ministry of Science, Technology, Innovations, and Communications, the International Center for Theoretical Physics South American Institute for Fundamental Research (ICTP-SAIFR), the Research Grants Council of Hong Kong, the National Natural Science Foundation of China (NSFC), the Leverhulme Trust, the Research Corporation, the Ministry of Science and Technology (MOST), Taiwan and the Kavli Foundation. The authors gratefully acknowledge the support of the NSF, STFC, INFN and CNRS for provision of computational resources.
Published: 2021

22. β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat

Author: Louise M Goff, Julia H. Goedecke, Amy E. Mendham, Jeroen Swart, Steven E Kahn, Ali Alhamud, Melony C Fortuin-de Smidt, Jon Hauksson, Olah Hakim, Darko Stefanovski, and Tommy Olsson
Subjects: 0301 basic medicine, β cell function, medicine.medical_specialty, insulin secretion, β-cell function, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, ectopic fat, Adipose tissue, 030209 endocrinology & metabolism, Type 2 diabetes, Endocrinology and Diabetes, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, hepatic insulin extraction, Internal Medicine, medicine, Hyperinsulinemia, Insulin secretion, business.industry, Insulin, Research, medicine.disease, RC648-665, Obesity, peripheral insulin clearance, 030104 developmental biology, Endokrinologi och diabetes, Beta cell, business
Abstract: The role of ectopic fat, insulin secretion and clearance in the preservation ofβ-cell function in black African women with obesity who typically present with hyperinsulinaemia is not clear. We aim to examine the associations between disposition index (DI, an estimate of β-cell function), insulin secretion and clearance and ectopic fat deposition. This is a cross-sectional study of 43 black South African women (age 20–35 years) with obesity (BMI 30–40 kg/m2) and without type 2 diabetes that measured the following: DI, insulin sensitivity (SI), acute insulin response (AIRg), insulin secretion rate (ISR), hepatic insulin extraction and peripheral insulin clearance (frequently sampled i.v. glucose tolerance test); pancreatic and hepatic fat, visceral adipose tissue (VAT) and abdominal s.c. adipose tissue (aSAT) volume (MRI), intra-myocellular (IMCL) and extra-myocellular fat content (EMCL) (magnetic resonance spectroscopy). DI correlated positively with peripheral insulin clearance (β 55.80, P = 0.002). Higher DI was associated with lower VAT, pancreatic fat and soleus fat, but VAT explained most of the variance in DI (32%). Additionally, higher first phase ISR (P = 0.033) and lower hepatic insulin extraction (P = 0.022) were associated with lower VAT, independent from SI, rather than with ectopic fat. In conclusion, peripheral insulin clearance emerged as an important correlate of DI. However, VAT was the main determinant of a lower DI above ectopic fat depots. Importantly, VAT, but not ectopic fat, is associated with both lower insulin secretion and higher hepatic insulin extraction. Prevention of VAT accumulation in young black African women should, therefore, be an important target for beta cell preservation.
Published: 2021

23. C4 article: Implications of COVID-19 in transplantation

Author: Daniel E. Dulek, Michael G. Ison, Cristiano Amarelli, Atul Humar, Emily A. Blumberg, Maria Irene Bellini, Crystal Truax, Rebecca Pellett Madan, Ekamol Tantisattamo, Marwan M. Azar, Neeraj Singh, Camilla W. Nonterah, Santiago M.C. Lopez, Deepali Kumar, Lara Danziger-Isakov, Lilian M. Abbo, Nicole Theodoropoulos, Annelise Nolan, Marion Hemmersbach-Miller, Felipe Alconchel, Gustavo Fernandes Ferreira, Melissa A. Greenwald, Emmanouil Giorgakis, Alessandro Gambella, James R. Rodrigue, Kenneth J. Woodside, Michelle T Jesse, Jonathan Hand, Patti Niles, Valerie Demekhin, Wendy Balliet, Benito Valdepenas, Kristina L. Goff, Naoka Murakami, Armelle Perez Cortes Villalobos, Benjamin A. Miko, Melissa R. Gitman, Justin G. Aaron, Amany Sholkamy, Monica I. Ardura, Nicole A. Pilch, Kristin Kronsnoble, Andrés Jaramillo, Scott G. Westphal, Krista L. Lentine, Jamil Azzi, John W Baddley, Camille N. Kotton, Dhruva Sharma, Shweta Anjan, Mia Schmiedeskamp-Rahe, Sumit Mohan, Jeong M. Park, Yasemin Tezer, Lisa M. Potter, Heather Bruschwein, James A. Blumenthal, Michael Green, Ricardo M. La Hoz, Marcus R. Pereira, and Deborah Verran
Subjects: infection and infectious agents, medicine.medical_specialty, infection and infectious agents - viral, Tissue and Organ Procurement, Coronavirus disease 2019 (COVID-19), infectious disease, clinical research/practice, Dexamethasone, Humans, Immunology and Allergy, Medicine, organ transplantation in general, Pharmacology (medical), Child, Intensive care medicine, Transplantation, business.industry, infection and infectious agents – viral, COVID-19, Original Articles, Organ Transplantation, Tissue Donors, Clinical research/practice, viral, Infectious disease (medical specialty), COVID-19 Nucleic Acid Testing, Original Article, business
Abstract: A novel coronavirus has had global impact on individual health and health care delivery. In this C4 article, contributors discuss various aspects of transplantation including donor and recipient screening, management of infected patients, and prevention of coronavirus disease (COVID). Donor screening with SARS-CoV-2 nucleic acid testing (NAT) close to the time of procurement is recommended. Many programs are also screening all potential recipients at the time of admission. The management of COVID has evolved with remdesivir emerging as a new potential option for transplant recipients. Dexamethasone has also shown promise and convalescent plasma is under study. Prevention strategies for transplant candidates and recipients are paramount. Pediatric-specific issues are also discussed. Strategies for the psychological well-being of patients and providers are also imperative, in addition to future research priorities for transplantation.
Published: 2021

24. La prévention du suicide en milieu agricole

Author: Laurent Le Goff and Tiphaine Bouldoires
Subjects: Excess mortality, Agriculture, business.industry, Political science, Specific risk, Context (language use), Christian ministry, General Medicine, Pshychiatric Mental Health, business, Socioeconomics
Abstract: The French agricultural sector is strongly affected by suicide. Various studies show that there is an excess mortality rate among people working in this sector. Although specific risk factors have been identified, the Ministry of Agriculture and Food has identified prevention as a national priority. In this context, the 'sentinel' training of peers in the world of agriculture is an essential lever which, over the years, is beginning to bear fruit.
Published: 2021

25. First-in-Human PET Imaging and Estimated Radiation Dosimetry of l-[5-11C]-Glutamine in Patients with Metastatic Colorectal Cancer

Author: Tiffany L Hickman, Satya Das, Jennifer G. Whisenant, Jordan Berlin, Todd E. Peterson, Robert J. Coffey, Allison S Cohen, Gary T. Smith, Kristen K. Ciombor, Cathy Eng, Henry Charles Manning, Laura W. Goff, Joe Grudzinski, and Dana Backlund Cardin
Subjects: Biodistribution, PET-CT, medicine.diagnostic_test, business.industry, Colorectal cancer, Cancer, medicine.disease, Glutamine, medicine.anatomical_structure, Positron emission tomography, Medicine, Dosimetry, Radiology, Nuclear Medicine and imaging, business, Pancreas, Nuclear medicine
Abstract: Altered metabolism is a hallmark of cancer. In addition to glucose, glutamine is an important nutrient for cellular growth and proliferation. Non-invasive imaging via positron emission tomography (PET) may help facilitate precision treatment of cancer through patient selection and monitoring of treatment response. L-[5-11C]-glutamine (11C-glutamine) is a PET tracer designed to study glutamine uptake and metabolism. The aim of this first-in-human study was to evaluate the radiologic safety and biodistribution of 11C-glutamine for oncologic PET imaging. Methods: Nine patients with confirmed metastatic colorectal cancer underwent PET/computed tomography (CT) imaging. Patients received 337.97 ± 44.08 MBq of 11C-glutamine. Dynamic PET acquisitions centered over the abdomen or thorax were initiated simultaneously with intravenous tracer administration. Following the dynamic acquisition, a whole-body PET/CT was acquired. Volume-of-interest analyses were carried out to obtain estimates of organ-based absorbed doses of radiation. Results:11C-glutamine was well-tolerated in all patients with no observed safety concerns. Organs with the highest radiation exposure included the bladder, pancreas, and liver. The estimated effective dose was 4.46E-03 ± 7.67E-04 mSv/MBq. Accumulation of 11C-glutamine was elevated and visualized in lung, brain, bone, and liver metastases, suggesting utility for cancer imaging. Conclusion: PET using 11C-glutamine appears safe for human use and allows non-invasive visualization of metastatic colon cancer lesions in multiple organs. Further studies are needed to elucidate its potential for other cancers and for monitoring response to treatment.
Published: 2021

26. Randomized Controlled Trial of Topical Skin Adhesive vs Nylon Sutures for Incision Closure in Forefoot Surgery

Author: Jagwinder Dhaliwal, Thomas J Goff, Karen Fogarty, Alice Chang, C Ruth Varrall, Andrew Wines, Paul M. C. Dearden, Peter W. Robinson, Robbie Ray, and Thomas L. Lewis
Subjects: medicine.medical_specialty, law.invention, Forefoot surgery, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Adhesives, Humans, Medicine, Orthopedics and Sports Medicine, Prospective Studies, 030212 general & internal medicine, Wound Healing, 030222 orthopedics, Sutures, Nylon sutures, business.industry, Suture Techniques, Surgery, Nylons, Wound management, Cyanoacrylate, Tissue Adhesives, Adhesive, business
Abstract: Background: There are many options for incision closure in forefoot surgery. The aim of this study was to compare topical skin adhesive (2-octyl-cyanoacrylate) to simple interrupted nylon sutures. Methods: A prospective randomized controlled trial comparing topical skin adhesive (TSA) and nylon sutures (NSs) for elective open forefoot surgery. Primary outcome was Hollander Wound Evaluation Scale (HWES) assessed 2 weeks following surgery. Secondary objectives included time taken for wound closure, wound assessment, patient satisfaction with wound cosmesis, incision pain, and infection rate. Results: Between January and December 2018, 84 feet (70 patients) underwent hallux valgus scarf/Akin osteotomy or first metatarsophalangeal arthrodesis and were randomized to receive either intervention (topical skin adhesive) or control (3/0 nylon sutures). We found worse HWES scores when using TSA compared to NSs (1.07 vs 0.60). Incision closure time was slower for TSA (mean, 272 vs 229 seconds). At 2 weeks postoperatively, wound care was faster for TSA (mean 71 secs) vs NSs (mean 120), and patient-reported pain was less with TSA (visual analog scale: TSA 1.2 vs NSs 2.1). A high degree of overall patient satisfaction was reported in both groups, without significant difference. Conclusion: Closure of elective forefoot surgery incisions with topical skin adhesive or interrupted nylon sutures offers high satisfaction rates, low pain scores, and low complications. However, topical skin adhesive was associated with more inflammation and areas of wound separation compared to nylon sutures. We recommend the use of sutures for wound closure in forefoot surgery. Level of Evidence: Level I, randomized controlled trial.
Published: 2021

27. Radiation and Modulation of the Tumor Immune Microenvironment in Non–Small Cell Lung Cancer

Author: Ramesh Rengan, Stephanie K. Schaub, Peter H. Goff, and Jing Zeng
Subjects: Cancer Research, Lung Neoplasms, medicine.medical_treatment, Immune microenvironment, Locally advanced, 030218 nuclear medicine & medical imaging, Unmet needs, 03 medical and health sciences, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Tumor Microenvironment, medicine, Humans, Radiology, Nuclear Medicine and imaging, Lung cancer, Antitumor immunity, business.industry, medicine.disease, Combined Modality Therapy, Radiation therapy, Clinical trial, Oncology, 030220 oncology & carcinogenesis, Cancer research, Immunotherapy, Non small cell, business
Abstract: Immune checkpoint inhibitors are approved for a variety of indications for locally advanced and metastatic non-small cell lung cancer (NSCLC), and trials are ongoing in the early-stage setting. There is an unmet need to understand which patients may derive benefit from immunotherapies and how to harness combined modality therapies to improve overall response rates and durability. Here, we review studies from the bench-to-bedside to examine the role of radiation therapy (RT) on the tumor immune microenvironment in NSCLC with an eye toward augmenting antitumor immunity. Together, these data provide a foundation for developing future clinical trials harnessing RT to augment antitumor immunity and highlight the need for correlative translational studies to directly characterize the impact of RT on the human NSCLC tumor immune microenvironment.
Published: 2021

28. Responsiveness and Minimal Clinically Important Difference of the Motor Function Measure in Collagen VI-Related Dystrophies and Laminin Alpha2-Related Muscular Dystrophy

Author: Sandra Donkervoort, P. Rippert, A. Reghan Foley, Gina Norato, M. Waite, Margaret Fink, Carole Vuillerot, Carsten G. Bönnemann, Katherine G. Meilleur, Minal S. Jain, and Laure Le Goff
Subjects: Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Neuromuscular disease, Adolescent, Duchenne muscular dystrophy, Minimal Clinically Important Difference, Physical Therapy, Sports Therapy and Rehabilitation, Motor Activity, Muscular Dystrophies, Cohort Studies, Disability Evaluation, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Floor effect, medicine, Humans, Longitudinal Studies, Prospective Studies, Muscular dystrophy, Child, business.industry, Minimal clinically important difference, Rehabilitation, medicine.disease, Child, Preschool, Congenital muscular dystrophy, Female, 0305 other medical science, business, 030217 neurology & neurosurgery, Natural history study, Cohort study
Abstract: Objectives To investigate the responsiveness of the motor function measure (MFM) and determine the minimal clinically important difference (MCID) in individuals with 2 common types of congenital muscular dystrophy (CMD). Design Observational, prospective, single center, cohort study. Setting National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH). Participants Individuals (N=44) with collagen VI-related dystrophies (COL6-RD, n=23) and 21 individuals laminin alpha2-related muscular dystrophy (LAMA2-RD, n=21) enrolled in a 4-year longitudinal natural history study. Interventions Not applicable. Main Outcome Measures Responsiveness of the MFM-32 and the Rasch-scaled MFM-25 and the MCID of the MFM-32 determined from a patient-reported anchor with 2 different methods, within-patient and between-patient. Results The original MFM-32 and Rasch-scaled MFM-25 performed similarly overall in both the COL6-RD and LAMA2-RD populations, with all subscores (D1, standing and transfers; D2, axial and proximal; D3, distal) showing a significant decrease over time, except MFM D1 and D3 for LAMA2-RD. The MFM D1 subscore was the most sensitive to change for ambulant individuals, whereas the MFM D2 subscore was the most sensitive to change for nonambulant individuals. The MCID for the MFM-32 total score was calculated as 2.5 and 3.9 percentage points according to 2 different methods. Conclusions The MFM showed strong responsiveness in individuals with LAMA2-RD and COL6-RD. Because a floor effect was identified more prominently with the Rasch-Scaled MFM-25, the use of the original MFM-32 as a quantitative variable with the assumption of scale linearity appears to be a good compromise. When designing clinical trials in congenital muscular dystrophies, the use of MCID for MFM should be considered to determine if a given intervention effects show not only a statistically significant change but also a clinically meaningful change.
Published: 2021

29. Subgenual cingulate resting regional cerebral blood flow in premenstrual dysphoric disorder: differential regulation by ovarian steroids and preliminary evidence for an association with expression of ESC/E(Z) complex genes

Author: Philip Kohn, Peter Schmidt, Steven J. Soldin, Allison Goff, J. Shane Kippenhan, Pedro E. Martinez, Karen F. Berman, David R. Rubinow, Howard J. Li, Erica B. Baller, David Goldman, and Shau-Ming Wei
Subjects: Agonist, medicine.medical_specialty, medicine.drug_class, Article, lcsh:RC321-571, Cellular and Molecular Neuroscience, Basal (phylogenetics), Internal medicine, Gene expression, medicine, Humans, Gene, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Progesterone, Biological Psychiatry, Estradiol, business.industry, ESC/E(Z) complex, medicine.disease, Psychiatry and Mental health, Endocrinology, Cerebral blood flow, Cerebrovascular Circulation, Female, Steroids, Psychiatric disorders, Premenstrual Dysphoric Disorder, business, Premenstrual dysphoric disorder, Neuroscience, Hormone
Abstract: Substantial evidence suggests that circulating ovarian steroids modulate behavior differently in women with PMDD than in those without this condition. However, hormonal state-related abnormalities of neural functioning in PMDD remain to be better characterized. In addition, while altered neural function in PMDD likely co-exists with alterations in intrinsic cellular function, such a relationship has not been explored. Here, we investigated the effects of ovarian steroids on basal, resting regional cerebral blood flow (rCBF) in PMDD, and, in an exploratory analysis, we tested whether the rCBF findings were linked to the expression of ESC/E(Z) genes, which form an essential ovarian steroid-regulated gene-silencing complex. Resting rCBF was measured with oxygen-15 water PET (189 PET sessions in 43 healthy women and 20 women with PMDD) during three self-as-own-control conditions: GnRH agonist (Lupron)-induced ovarian suppression, estradiol add-back, and progesterone add-back. ESC/E(Z) gene expression data were obtained from RNA-sequencing of lymphoblastoid cell lines performed in a previous study and were examined in relation to hormone-induced changes in rCBF. In the rCBF PET data, there was a significant diagnosis-by-hormone interaction in the subgenual cingulate (PFDR = 0.05), an important neuroanatomical hub for regulating affective state. Whereas control women showed no hormonally-related changes in resting rCBF, those with PMDD showed decreased resting rCBF during both estradiol (P = 0.02) and progesterone (P = 0.0002) add-back conditions. In addition, in PMDD, ESC/E(Z) gene expression correlated with the change in resting rCBF between Lupron-alone and progesterone conditions (Pearson r = −0.807, P = 0.016). This work offers a formulation of PMDD that integrates behavioral, neural circuit, and cellular mechanisms, and may provide new targets for future therapeutic interventions.
Published: 2021

30. Pemphigus foliaceus presenting with violaceous, painful nodules and an aberrant auto-antibody expression in a Latino patient

Author: Cristian D. Gonzalez, Travis Vandergriff, Jeffrey N. Li, Parth A Patel, and Heather W. Goff
Subjects: Latino, medicine.medical_specialty, DSG-1, desmoglein-1, pemphigus vulgaris, Case Report, Dermatology, Desmoglein, Antibody expression, skin of color, PF, pemphigus foliaceus, medicine, lcsh:Dermatology, pemphigus foliaceus, education, Pemphigus foliaceus, education.field_of_study, business.industry, Pemphigus vulgaris, lcsh:RL1-803, medicine.disease, PV, pemphigus vulgaris, DSG-3, desmoglein-3, Desmoglein 1, Desmoglein 3, desmoglein, business
Published: 2021

31. The 'Crime on Campus' Study: Course-Based Undergraduate Research and Student Confidence

Author: Katherine McLean, Charles Goff, and Laura Cruz
Subjects: Medical education, Higher education, business.industry, 050901 criminology, 05 social sciences, 050301 education, Education, Course (navigation), Undergraduate research, ComputingMilieux_COMPUTERSANDEDUCATION, 0509 other social sciences, Psychology, business, 0503 education, Law, Value (mathematics), Criminal justice
Abstract: Undergraduate Research Activity (URA) has been shown to add value to numerous higher education programs, driving improvements in course learning, campus engagement, and college retention. Yet, URA ...
Published: 2021

32. Predicting the Pseudocapacitive Windows for MXene Electrodes with Voltage-Dependent Cluster Expansion Models

Author: Francisco Marques dos Santos Vieira, James M. Goff, Nathan Keilbart, Yasuaki Okada, and Ismaila Dabo
Subjects: Materials science, business.industry, Monte Carlo method, Energy Engineering and Power Technology, Nitride, Electrochemistry, Energy storage, Carbide, Electrode, Pseudocapacitor, Materials Chemistry, Chemical Engineering (miscellaneous), Optoelectronics, Electrical and Electronic Engineering, business, Cluster expansion
Abstract: MXene transition-metal carbides and nitrides are of growing interest for energy storage applications. These compounds are especially promising for use as pseudocapacitive electrodes due to their ab...
Published: 2021

33. Genetic mechanisms of critical illness in COVID-19

Author: Pairo-Castineira, Erola, Clohisey, Sara, Klaric, Lucija, Bretherick, Andrew D, Rawlik, Konrad, Pasko, Dorota, Walker, Susan, Parkinson, Nick, Fourman, Max Head, Russell, Clark D, Furniss, James, Richmond, Anne, Gountouna, Elvina, Wrobel, Nicola, Harrison, David, Wang, Bo, Yang, Wu, Meynert, Alison, Griffiths, Fiona, Oosthuyzen, Wilna, Kousathanas, Athanasios, Moutsianas, Loukas, Yang, Zhijian, Zhai, Ranran, Zheng, Chenqing, Grimes, Graeme, Beale, Rupert, Millar, Jonathan, Shih, Barbara, Keating, Sean, Zechner, Marie, Haley, Chris, Porteous, David J, Hayward, Caroline, Yang, Jian, Knight, Julian, Summers, Charlotte, Shankar-Hari, Manu, Klenerman, Paul, Turtle, Lance, Antonia, Ho, Moore, Shona C, Hinds, Charles, Horby, Peter, Nichol, Alistair, Maslove, David, Ling, Lowell, Mcauley, Danny, Montgomery, Hugh, Walsh, Timothy, Pereira, Alexandre C, Renieri, Johnny, Millar, Alistair, Nichol, Tim, Walsh, Manu, Shankar-Hari, Chris, Ponting, Jen, Meikle, Paul, Finernan, Ellie, Mcmaster, Andy, Law, J Kenneth Baillie, Trevor, Paterson, Tony, Wackett, Ruth, Armstrong, Richard, Clark, Audrey, Coutts, Lorna, Donnelly, Tammy, Gilchrist, Katarzyna, Hafezi, Louise, Macgillivray, Alan, Maclean, Sarah, Mccafferty, Kirstie, Morrice, Jane, Weaver, Ceilia, Boz, Ailsa, Golightly, Mari, Ward, Hanning, Mal, Helen, Szoor-McElhinney, Adam, Brown, Ross, Hendry, Andrew, Stenhouse, Louise, Cullum, Dawn, Law, Sarah, Law, Rachel, Law, Maaike, Swets, Nicky, Day, Filip, Taneski, Esther, Duncan, Nicholas, Parkinson, Collier, D, Wood, S, Zak, A, Borra, C, Matharu, M, May, P, Alldis, Z, Mitchelmore, O, Bowles, R, Easthope, A, Bibi, F, Lancoma-Malcolm, I, Gurasashvili, J, Pheby, J, Shiel, J, Bolton, M, Patel, M, Taylor, M, Zongo, O, Ebano, P, Harding, P, Astin-Chamberlain, R, Choudhury, Y, Cox, A, Kallon, D, Burton, M, Hall, R, Blowes, S, Prime, Z, Biddle, J, Prysyazhna, O, Newman, T, Tierney, C, Kassam, J, Shankar-Hari, M, Ostermann, M, Campos, S, Bociek, A, Lim, R, Grau, N, O Jones, T, Whitton, C, Marotti, M, Arbane, G, Bonner, S, Hugill, K, Reid, J, Welters, I, Waugh, V, Williams, K, Shaw, D, J Fernandez Roman, M Lopez Martinez, Johnson, E, Waite, A, Johnston, B, Hamilton, D, Mulla, S, Mcphail, M, Smith, J, K Baillie, J, Barclay, L, Hope, D, Mcculloch, C, Mcquillan, L, Clark, S, Singleton, J, Priestley, K, Rea, N, Callaghan, M, Campbell, R, Andrew, G, Marshall, L, Mckechnie, S, Hutton, P, Bashyal, A, Davidson, N, Summers, C, Polgarova, P, Stroud, K, Pathan, N, Elston, K, Agrawal, S, Battle, C, Newey, L, Rees, T, Harford, R, Brinkworth, E, Williams, M, Murphy, C, White, I, Croft, M, Bandla, N, Gellamucho, M, Tomlinson, J, Turner, H, Davies, M, Quinn, A, Hussain, I, Thompson, C, Parker, H, Bradley, R, Griffiths, R, Scriven, J, Nilsson, A, Bates, M, Dasgin, J, Gill, J, Puxty, A, Cathcart, S, Salutous, D, Turner, L, Duffy, K, Puxty, K, Joseph, A, Herdman-Grant, R, Simms, R, Swain, A, Naranjo, A, Crowe, R, Sollesta, K, Loveridge, A, Baptista, D, Morino, E, Davey, M, Golden, D, Jones, J, J Moreno Cuesta, Haldeos, A, Bakthavatsalam, D, Vincent, R, Elhassan, M, Xavier, K, Ganesan, A, Purohit, D, Abdelrazik, M, Morgan, J, Akeroyd, L, Bano, S, Lawton, T, Warren, D, Bromley, M, Sellick, K, Gurr, L, Wilkinson, B, Nagarajan, V, Szedlak, P, Cupitt, J, Stoddard, E, Benham, L, Preston, S, Laha, S, Slawson, N, Bradshaw, Z, Brown, J, Caswell, M, Melling, S, Bamford, P, Faulkner, M, Cawley, K, Jeffrey, H, London, E, Sainsbury, H, Nagra, I, Nasir, F, Dunmore, C, Jones, R, Abraheem, A, Al-Moasseb, M, Girach, R, Padden, G, Egan, J, Brantwood, C, Alexander, P, Bradley-Potts, J, Allen, S, Felton, T, Manna, S, Farnell-Ward, S, Leaver, S, Queiroz, J, Maccacari, E, Dawson, D, C Castro Delgado, R Pepermans Saluzzio, Ezeobu, O, Ding, L, Sicat, C, Kanu, R, Durrant, G, Texeira, J, Harrison, A, Samakomva, T, Willis, H, Hopkins, B, Thrasyvoulou, L, Jackson, M, Zaki, A, Tibke, C, Bennett, S, Woodyatt, W, Kent, A, Goodwin, E, Brandwood, C, Clark, R, Smith, L, Rooney, K, Thomson, N, Rodden, N, Hughes, E, Mcglynn, D, Clark, C, Clark, P, Abel, L, Sundaram, R, Gemmell, L, Brett, M, Hornsby, J, Macgoey, P, Price, R, Digby, B, O'Neil, P, Mcconnell, P, Henderson, P, Henderson, S, Sim, M, Kennedy-Hay, S, Mcparland, C, Rooney, L, Baxter, N, Pogson, D, Rose, S, Daly, Z, Brimfield, L, K Phull, M, Hussain, M, Pogreban, T, Rosaroso, L, Salciute, E, Grauslyte, L, Brealey, D, Raith, E, Maccallum, N, Bercades, G, Hass, I, Smyth, D, Reyes, A, Martir, G, D Clement, I, Webster, K, Hays, C, Gulati, A, Hodgson, L, Margarson, M, Gomez, R, Baird, Y, Thirlwall, Y, Folkes, L, Butler, A, Meadows, E, Moore, S, Raynard, D, Fox, H, Riddles, L, King, K, Kimber, S, Hobden, G, Mccarthy, A, Cannons, V, Balagosa, I, Chadbourn, I, Gardner, A, Horner, D, Mclaughlanv, D, Charles, B, Proudfoot, N, Marsden, T, Mcmorrow, L, Blackledge, B, Pendlebury, J, Harvey, A, Apetri, E, Basikolo, C, Catlow, L, Doonan, R, Knowles, K, Lee, S, Lomas, D, Lyons, C, Perez, J, Poulaka, M, Slaughter, M, Slevin, K, Thomas, V, Walker, D, Harris, J, Drummond, A, Tully, R, Dearden, J, Philbin, J, Munt, S, Rishton, C, O'Connor, G, Mulcahy, M, Dobson, E, Cuttler, J, Edward, M, Norris, J, Hanson, K, Poole, A, Rose, A, Sloan, B, Buckley, S, Brooke, H, Smithson, E, Charlesworth, R, Sandhu, R, Thirumaran, M, Wagstaff, V, J Cebrian Suarez, Kaliappan, A, Vertue, M, Nicholson, A, Riches, J, Solesbury, A, Kittridge, L, Forsey, M, Maloney, G, Cole, J, Davies, R, Hill, H, Thomas, E, Williams, A, Duffin, D, Player, B, Radhakrishnan, J, Gibson, S, Lyle, A, Mcneela, F, Patel, B, Gummadi, M, Sloane, G, Dormand, N, Salmi, S, Farzad, Z, Cristiano, D, Liyanage, K, Thwaites, V, Varghese, M, Meredith, M, Mills, G, Willson, J, Harrington, K, Lenagh, B, Cawthron, K, Masuko, S, Raithatha, A, Bauchmuller, K, Wiles, M, Ahmad, N, Barker, J, Jackson, Y, Kibutu, F, Bird, S, Watson, G, Martin, J, Bevan, E, C Wrey Brown, Trodd, D, English, K, Bell, G, Wilcox, L, Katary, A, Gopal, S, Lake, V, Harris, N, Metherell, S, Radford, E, Moore, F, 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S, Dennis, C, Sukha, A, Verlander, M, Holding, K, Riches, K, Downes, C, Swan, C, Rostron, A, Roy, A, Woods, L, Cornell, S, Wakinshaw, F, Creagh-Brown, B, Blackman, H, Salberg, A, Smith, E, Donlon, S, Mtuwa, S, Michalak-Glinska, N, Stone, S, Beazley, C, Pristopan, V, Nikitas, N, Lankester, L, Wells, C, S Raj, A, Fletcher, K, Khade, R, Tsinaslanidis, G, Macmahon, M, Fowler, S, Coventry, T, Stewart, R, Wren, L, Mwaura, E, Mew, L, Scaletta, D, Williams, F, Inweregbu, K, Lancaster, N, Cunningham, M, Daniels, A, Harrison, L, Hope, S, Jones, S, Crew, A, Wray, G, Matthews, J, Crawley, R, Carter, J, Birkinshaw, I, Ingham, J, Scott, Z, Pearson, H, Howard, K, Joy, R, Roche, S, Clark, M, Purvis, S, Morrison, A, Strachan, D, Clements, S, Black, K, Parmar, C, Altabaibeh, A, Simpson, K, Mostoles, L, Gilbert, K, L, Ma, Alvaro, A, Thomas, M, Faulkner, B, Worner, R, Hayes, K, Gendall, E, Blakemore, H, Borislavova, B, Goff, E, Vuylsteke, A, Mwaura, L, Zamikula, J, Garner, L, Mitchell, A, Mepham, S, 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Wei Shen Lim, Alexander, J Mentzer, Laura, Merson, Alison, M Meynert, Mahdad, Noursadeghi, Shona, C Moore, Massimo, Palmarini, William, A Paxton, Georgios, Pollakis, Nicholas, Price, Andrew, Rambaut, David, L Robertson, Vanessa, Sancho-Shimizu, Janet, T Scott, Thushan de Silva, Louise, Sigfrid, Tom, Solomon, Shiranee, Sriskandan, David, Stuart, Richard, S Tedder, Emma, C Thomson, A Roger Thompson, A, Ryan, S Thwaites, Lance C, W Turtle, Maria, Zambon, Hayley, Hardwick, Chloe, Donohue, Ruth, Lyons, Lisa, Norman, Riinu, Pius, Thomas, M Drake, Cameron, J Fairfield, Stephen, R Knight, Kenneth, A Mclean, Derek, Murphy, Catherine, A Shaw, Dalton, Jo, Michelle, Girvan, Egle, Saviciute, Stephanie, Roberts, Janet, Harrison, Laura, Marsh, Marie, Connor, Sophie, Halpin, Clare, Jackson, Carrol, Gamble, Gary, Leeming, Murray, Wham, William, Greenhalf, Victoria, Shaw, Sara, Mcdonald, Seán, Keating, Andrea, Ganna, Patrick, Sulem, David, A van Heel, Mattia, Cordioli, Gardar, Sveinbjornsson, Mari E, K 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Konrad [0000-0002-0010-370X], Walker, Susan [0000-0002-5016-6426], Fourman, Max Head [0000-0001-7381-2278], Russell, Clark D [0000-0002-9873-8243], Gountouna, Elvina [0000-0001-7870-2780], Wang, Bo [0000-0002-1580-797X], Wu, Yang [0000-0002-0128-7280], Kousathanas, Athanasios [0000-0001-6265-6521], Moutsianas, Loukas [0000-0001-5453-345X], Zhai, Ranran [0000-0002-5834-9120], Beale, Rupert [0000-0002-6705-8560], Keating, Sean [0000-0001-8552-5604], Haley, Chris [0000-0002-9811-0210], Porteous, David J [0000-0003-1249-6106], Hayward, Caroline [0000-0002-9405-9550], Yang, Jian [0000-0003-2001-2474], Knight, Julian [0000-0002-0377-5536], Summers, Charlotte [0000-0002-7269-2873], Shankar-Hari, Manu [0000-0002-5338-2538], Turtle, Lance [0000-0002-0778-1693], Moore, Shona C [0000-0001-8610-2806], Hinds, Charles [0000-0001-5094-8324], McAuley, Danny [0000-0002-3283-1947], Montgomery, Hugh [0000-0001-8797-5019], Renieri, Alessandra [0000-0002-0846-9220], Shen, Xia [0000-0003-4390-1979], 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B., Turner, V., Savill, H., Mccormick, J., Coulding, M., Siddiqui, S., Mercer, O., Rehman, H., Potla, D., Capps, N., Donaldson, D., Button, H., Martin, T., Hard, K., Agasou, A., Tonks, L., Arden, T., Boyle, P., Carnahan, M., Strickley, J., Adams, C., Childs, D., Rikunenko, R., Leigh, M., Breekes, M., Wilcox, R., Bowes, A., Tiveran, H., Hurford, F., Summers, J., Carter, A., Hussain, Y., Ting, L., Javaid, A., Motherwell, N., Moore, H., Millward, H., Jose, S., Schunki, N., Noakes, A., Clulow, C., Sadera, G., Jacob, R., Jones, C., Blunt, M., Coton, Z., Curgenven, H., Ally, S. M., Beaumont, K., Elsaadany, M., Fernandes, K., Ali Mohamed Ali, I., Rangarajan, H., Sarathy, V., Selvanayagam, S., Vedage, D., White, M., Truman, N., Chukkambotla, S., Keith, S., Cockerill-Taylor, J., Ryan-Smith, J., Bolton, R., Springle, P., Dykes, J., Thomas, J., Khan, M., Hijazi, M. T., Massey, E., Croston, G., Reschreiter, H., Camsooksai, J., Patch, S., Jenkins, S., Humphrey, C., Wadams, B., Msiska, M., Adanini, O., Attwood, B., Parsons, P., Tatham, K., Jhanji, S., Black, E., Dela Rosa, A., Howle, R., Thomas, B., Bemand, T., Raobaikady, R., Saha, R., Staines, N., Daniel, A., Finn, J., Hutter, J., Doble, P., Shovelton, C., Pawley, C., Kannan, T., Hill, M., Combes, E., Monnery, S., Joefield, T., Popescu, M., Thankachen, M., Oblak, M., Little, J., Mcivor, S., Brady, A., Whittle, H., Prady, H., Chan, R., Ahmed, A., Morris, A., Gibson, C., Gordon, E., Keenan, S., Quinn, H., Benyon, S., Marriott, S., Zitter, L., Park, L., Baines, K., Lyons, M., Holland, M., Keenan, N., Young, M., Garrioch, S., Dawson, J., Tolson, M., Scholefield, B., Bi, R., Richardson, N., Schumacher, N., Cosier, T., Millen, G., Higham, A., Turki, S., Allen, L., Crisp, N., Hazleton, T., Knight, A., Deery, J., Price, C., Turney, S., Tilbey, S., Beranova, E., Wright, D., George, L., Twiss, S., Wadd, S., Postlethwaite, K., Gondo, P., Masunda, B., Kayani, A., Hadebe, B., Whiteside, J., Clarke, N., Donnison, P., Trim, F., Leadbitter, I., Butcher, D., O'Sullivan, S., Purewal, B., Bell, S., Rivers, V., O'Leary, R., Birch, J., Collins, E., Anderson, S., Hammerton, K., Andrews, E., Burns, K., Edmond, I., Todd, A., Donnachie, J., Turner, P., Prentice, L., Symon, L., Runciman, N., Auld, F., Halkes, M., Mercer, P., Thornton, L., Debreceni, G., Wilkins, J., Crickmore, V., Subramanian, G., Marshall, R., Jennings, C., Latif, M., Bunni, L., Spivey, M., Bean, S., Burt, K., Linnett, V., Ritzema, J., Sanderson, A., Mccormick, W., Bokhari, M., Kapoor, R., Loader, D., Ayers, A., Harrison, W., North, J., Belagodu, Z., Paramsothy, R., Olufuwa, O., Gherman, A., Fuller, B., Stuart, C., Kelsall, O., Davis, C., Wild, L., Wood, H., Thrush, J., Durie, A., Austin, K., Archer, K., Anderson, P., Vigurs, C., Thorpe, C., Knights, E., Boyle, N., Price, A., Kubisz-Pudelko, A., Wood, D., Lewis, A., Board, S., Pippard, L., Perry, J., Beesley, K., Rattray, A., Lee, E., Lennon, L., Douglas, K., Bell, D., Boyle, R., Glass, L., Nauman Akhtar, M., Dent, K., Potoczna, D., Pearson, S., Horsley, E., Spencer, S., Mullan, D., Skinner, D., Gaylard, J., Barber, R., Hewitt, C., Hilldrith, A., Shepardson, S., Wills, M., Jackson-Lawrence, K., Gupta, A., Timlick, E., Gorman, C., Otahal, I., Gales, A., Coetzee, S., Sell, C., Raj, M., Peiu, M., Quaid, S., Watson, E., Elliott, K., Mallinson, J., Chandler, B., Turnbull, A., Finch, C., Holl, C., Cooper, J., Evans, A., Khaliq, W., Collins, A., Gude, E. T., Love, N., van Koutrik, L., Hunt, J., Kaye, D., Fisher, E., Brayne, A., Tuckey, V., Jackson, P., Parkin, J., Tariq, A., Houlden, H., Tucci, A., Hardy, J., Moncur, E., Highgate, J., Cowley, A., Mitra, A., Stead, R., Behan, T., Burnett, C., Newton, M., Heeney, E., Pollard, R., Hatton, J., Patel, A., Kasipandian, V., Allibone, S., Genetu, R. M., O'Brien, L., Omar, Z., Perkins, E., Davies, K., Tetla, D., Shelley, B., Irvine, V., Williams, S., Williams, P., Goodsell, J., Tutton, R., Bough, L., Winter-Goodwin, B., Kitson, R., Pinnell, J., Wilson, A., Nortcliffe, T., Wood, T., Home, M., Holdroyd, K., Robinson, M., Shaw, R., Greig, J., Brady, M., Haigh, A., Matupe, L., Usher, M., Mellor, S., Dale, S., Gledhill, L., Shaw, L., Turner, G., Kelly, D., Anwar, B., Riley, H., Sturgeon, H., Ali, A., Thomis, L., Melia, D., Dance, A., Humphreys, S., Frost, I., Gopal, V., Godden, J., Holden, A., Swann, S., Smith, T., Clapham, M., Poultney, U., Harper, R., Rice, P., Reece-Anthony, R., Gurung, B., Moultrie, S., Odam, M., Mayer, A., Bellini, A., Pickard, A., Bryant, J., Roe, N., Sowter, J., Lang, K., Taylor, J., Barry, P., Hobrok, M., Tench, H., Wolf-Roberts, R., Mcguinness, H., Loosley, R., Hawcutt, D., Rad, L., O'Malley, L., Saunderson, P., Seddon, G., Anderson, T., Rogers, N., Ruddy, J., Harkins, M., Beith, C., Mcalpine, A., Ferguson, L., Grant, P., Macfadyen, S., Mclaughlin, M., Baird, T., Rundell, S., Welsh, B., Hamill, R., Fisher, F., Gregory, J., Campbell, A., Smuts, S., Kenneth Baillie, J., Carson, G., Alex, B., Bach, B., Barclay, W. S., Bogaert, D., Chand, M., Cooke, G. S., Docherty, A. B., Dunning, J., da Silva Filipe, A., Fletcher, T., Green, C. A., Harrison, E. M., Hiscox, J. A., Ho, A. Y. W., Horby, P. W., Ijaz, S., Khoo, S., Lim, W. S., Mentzer, A. J., Merson, L., Meynert, A. M., Noursadeghi, M., Palmarini, M., Paxton, W. A., Pollakis, G., Price, N., Rambaut, A., Robertson, D. L., Sancho-Shimizu, V., Scott, J. T., de Silva, T., Sigfrid, L., Solomon, T., Sriskandan, S., Stuart, D., Tedder, R. S., Thomson, E. C., Thompson, A. A. R., Thwaites, R. S., Turtle, L. C. W., Zambon, M., Hardwick, H., Donohue, C., Lyons, R., Norman, L., Pius, R., Drake, T. M., Fairfield, C. J., Knight, S. R., Mclean, K. A., Murphy, D., Shaw, C. A., Dalton, J., Girvan, M., Saviciute, E., Roberts, S., Harrison, J., Marsh, L., Connor, M., Halpin, S., Gamble, C., Leeming, G., Wham, M., Greenhalf, W., Shaw, V., Mcdonald, S., Ganna, A., Sulem, P., van Heel, D. A., Cordioli, M., Sveinbjornsson, G., Niemi, M. E. K., Shelton, J. F., Shastri, A. J., Ye, C., Weldon, C. H., Filshtein-Sonmez, T., Coker, D., Symons, A., Esparza-Gordillo, J., Aslibekyan, S., Auton, A., Krieger, J. E., Marques, E., Jannes, C. E., Mari, F., Daga, S., Baldassarri, M., Benetti, E., Furini, S., Fallerini, C., Fava, F., Valentino, F., Doddato, G., Giliberti, A., Tita, R., Amitrano, S., Bruttini, M., Croci, S., Meloni, I., Pinto, A. M., Frullanti, E., Mencarelli, M. A., Rizzo, C. L., Montagnani, F., Di Sarno, L., Tommasi, A., Palmieri, M., Emiliozzi, A., Fabbiani, M., Rossetti, B., Zanelli, G., Bargagli, E., Bergantini, L., D'Alessandro, M., Cameli, P., Bennet, D., Anedda, F., Marcantonio, S., Scolletta, S., Franchi, F., Mazzei, M. A., Guerrini, S., Conticini, E., Cantarini, L., Frediani, B., Tacconi, D., Spertilli, C., Feri, M., Donati, A., Scala, R., Guidelli, L., Spargi, G., Corridi, M., Nencioni, C., Croci, L., Caldarelli, G. P., Spagnesi, M., Piacentini, P., Bandini, M., Desanctis, E., Cappelli, S., Canaccini, A., Verzuri, A., Anemoli, V., Ognibene, A., Vaghi, M., D'Arminio Monforte, A., Merlini, E., Mondelli, M. U., Mantovani, S., Ludovisi, S., Girardis, M., Venturelli, S., Sita, M., Cossarizza, A., Antinori, A., Vergori, A., Rusconi, S., Siano, M., Gabrieli, A., Riva, A., Francisci, D., Schiaroli, E., Scotton, P. G., Andretta, F., Panese, S., Scaggiante, R., Gatti, F., Parisi, S. G., Castelli, F., Quiros-Roldan, M. E., Magro, P., Zanella, I., Della Monica, M., Piscopo, C., Capasso, M., Russo, R., Andolfo, I., Iolascon, A., Fiorentino, G., Carella, M., Castori, M., Merla, G., Aucella, F., Raggi, P., Marciano, C., Perna, R., Bassetti, M., Di Biagio, A., Sanguinetti, M., Masucci, L., Valente, S., Mandala, M., Giorli, A., Salerni, L., Zucchi, P., Parravicini, P., Menatti, E., Baratti, S., Trotta, T., Giannattasio, F., Coiro, G., Lena, F., Coviello, D. A., Mussini, C., Bosio, G., Martinelli, E., Mancarella, S., Tavecchia, L., Crotti, L., Picchiotti, N., Gori, M., Gabbi, C., Sanarico, M., Ceri, S., Pinoli, P., Raimondi, F., Biscarini, F., Stella, A., Shen, X., Ponting, C. P., Fawkes, A., Tenesa, A., Caulfield, M., Scott, R., Rowan, K., Murphy, L., Openshaw, P. J. M., Semple, M. G., Vitart, V., and Wilson, J. F.
Subjects: 0301 basic medicine, Male, CCR2, Chromosomes, Human, Pair 21, Genome-wide association study, Receptor, Interferon alpha-beta, Disease, Bioinformatics, Genome-wide association studies, 23andMe Investigators, Interferon alpha-beta, 0302 clinical medicine, Receptors, 2',5'-Oligoadenylate Synthetase, Pair 12, genetics, Lung, BRACOVID Investigators, Multidisciplinary, GenOMICC Investigators, Tyrosine kinase 2, 030220 oncology & carcinogenesis, Multigene Family, Medical genetics, Female, Dipeptidyl-Peptidases and Tripeptidyl-Peptidase, 5'-Oligoadenylate Synthetase, Human, Receptor, medicine.medical_specialty, Critical Care, Receptors, CCR2, General Science & Technology, Critical Illness, Chromosomes, 03 medical and health sciences, Intensive care, Mendelian randomization, Immunogenetics, medicine, Humans, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Gen-COVID Investigators, Inflammation, TYK2 Kinase, Chromosomes, Human, Pair 12, Pair 19, SARS-CoV-2, business.industry, Drug Repositioning, COVID-19, United Kingdom, COVID-19 Human Genetics Initiative, 030104 developmental biology, Viral infection, Chromosomes, Human, Pair 19, Genome-Wide Association Study, Pharmacogenomics, ISARICC Investigators, Pair 21, 2', business
Abstract: Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079,P=1.65×10−8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1,OAS2andOAS3); on chromosome 19p13.2 (rs74956615,P=2.3×10−8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069,P=3.98× 10−12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757,P=4.99×10−8) in the interferon receptor geneIFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression ofIFNAR2, or high expression ofTYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte–macrophage chemotactic receptorCCR2is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice.
Published: 2020
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34. On-Treatment Hypertension Control in a Real-World Cohort

Author: David C. Goff, Peter M. Okin, and S. Andrew McCullough
Subjects: medicine.medical_specialty, Health promotion, Treatment hypertension, business.industry, Lower blood pressure, Emergency medicine, Cohort, Medicine, Cardiology and Cardiovascular Medicine, business
Published: 2021

35. A phase I pharmacokinetic and safety study of Paclitaxel Injection Concentrate for Nano-dispersion (PICN) alone and in combination with carboplatin in patients with advanced solid malignancies and biliary tract cancers

Author: Mojun Zhu, Laura W. Goff, Mudgal Kothekar, Grace K. Dy, George A. Fisher, Antonio Jimeno, Elaine T. Lam, Jennifer R. Diamond, Lynne A. Bui, S. Gail Eckhardt, Alex A. Adjei, Akhil Sanghal, Geetanjali Chimote, Wen Wee Ma, Steven R. Alberts, Ajay Khopade, and Robert Faulkner
Subjects: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Cmax, Neutropenia, Toxicology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Pharmacology (medical), Paclitaxel Injection, Pharmacology, business.industry, medicine.disease, Carboplatin, 030104 developmental biology, Tolerability, chemistry, Paclitaxel, Biliary tract, 030220 oncology & carcinogenesis, business
Abstract: Paclitaxel injection concentrate for nano-dispersion (PICN) is a Cremophor-free, nanotechnology-driven paclitaxel formulation. This phase I study examined the safety, tolerability, pharmacokinetics and maximum tolerated dose (MTD) of PICN alone and in combination with carboplatin. Its early efficacy in unresectable biliary tract cancers (BTCs) was also evaluated. This multi-center study comprised two parts. Part A contained a dose-escalation cohort following “3 + 3” design using PICN monotherapy in advanced solid tumors (Part A1); Part A2 dose-expansion cohort was then conducted in advanced BTCs due to observed efficacy in Part A1. Part B1 and B2 evaluated escalating dose of PICN with carboplatin in advanced solid tumors. PICN was administered as a 30 min-infusion every 3 weeks without pre-medications for hypersensitivity reactions. Thirty-six patients received PICN monotherapy in Part A and 21 received PICN plus carboplatin in Part B. The MTD of PICN was determined to be 295 mg/m2 both as a monotherapy and in combination with carboplatin at AUC 5. Dose-proportional exposure in paclitaxel Cmax and AUC was observed overdose range from 175 to 325 mg/m2 for PICN monotherapy and its combination with carboplatin. Carboplatin did not alter PICN exposure. Clinically significant toxicities mainly include neutropenia and peripheral neuropathy. PICN monotherapy yielded a response rate of 20% in unresectable BTCs. This study demonstrated the safety and stable pharmacokinetics of PICN as a monotherapy and in combination with carboplatin. Single-agent PICN showed promising antitumor activity in advanced BTCs, warranting further studies to investigate its role in gastrointestinal cancers.
Published: 2021

36. Ethical responsibilities of tenured academics supervising non-tenured researchers in times of neoliberalism and precarity

Author: Jess Harris, Kathleen Smithers, Nerida Spina, Simon Bailey, and Mhorag Goff
Subjects: Sociological theory, Sociology and Political Science, Casual, business.industry, media_common.quotation_subject, Precarious Employment, Neoliberalism, Public relations, Education, Ethical leadership, Precarity, Work (electrical), Sociology, business, Working environment, media_common
Abstract: Neoliberal reform of the university sector has resulted in increasing numbers of academics employed on casual or fixed-term contracts. While there is an emergent body of literature on issues of precarity in the academy, relatively little attention has been paid to the roles and responsibilities of those tenured academics who employ and manage non-tenured researchers. The work involved in hiring and managing a contract researcher is rarely acknowledged or supported, and managers receive little to no training. In this paper, we draw on Dorothy Smith’s feminist sociological approach to analyse interviews with 22 non-tenured researchers to examine how managerial relationships shape the employment experiences of those working precariously. We argue that tenured academics have ethical responsibilities to provide a working environment that is fair, supports the ongoing development and wellbeing of non-tenured staff, and challenges dominant discourses of precarious academics as ‘other’.
Published: 2021

37. OPTN/SRTR 2019 Annual Data Report: Heart

Author: Bertram L. Kasiske, Yoon Son Ahn, E. Messick, R. Goff, Ajay K. Israni, M. A. Skeans, Jon J. Snyder, Monica Colvin, J. Foutz, K Bradbrook, and Jodi M. Smith
Subjects: Adult, Heart transplants, Transplantation, Pediatrics, medicine.medical_specialty, Tissue and Organ Procurement, Waiting Lists, business.industry, Mortality rate, medicine.medical_treatment, Graft Survival, Tissue Donors, United States, Resource Allocation, surgical procedures, operative, Ventricular assist device, medicine, Humans, Immunology and Allergy, Pharmacology (medical), End stage heart failure, Child, business
Abstract: The new adult heart allocation policy was approved in 2016 and implemented in October 2018. This year's Annual Data Report provides early insight into the effects of this policy. In 2019, new listings continued to increase, with 4086 new candidates. Also in 2019, 3597 heart transplants were performed, an increase of 157 (4.6%) from 2018; 509 transplants occurred in children and 3088 in adults. Short- and long-term posttransplant mortality rates improved. Overall, Mortality rates for adult recipients were 6.4% at 6 months and 7.9% at 1 year for transplants in 2018, 14.4% at 3 years for transplants in 2016, and 20.1% at 5 years for transplants in 2014. Mortality rates for pediatric recipients were 6.3% at 6 months and 8.2% at 1 year for transplants in 2018, 10.3% at 3 years for transplants in 2016, and 17.8% at 5 years for transplants in 2014.
Published: 2021

38. OPTN/SRTR 2019 Annual Data Report: Lung

Author: Jon J. Snyder, J. Foutz, R. Goff, Ajay K. Israni, Carli J. Lehr, Maryam Valapour, E. Miller, Jodi M. Smith, Bertram L. Kasiske, and Melissa Skeans
Subjects: Transplantation, Lung transplants, Tissue and Organ Procurement, Lung, Waiting Lists, business.industry, Graft Survival, Equity (finance), 030230 surgery, Tissue Donors, United States, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Humans, Immunology and Allergy, Medicine, Pharmacology (medical), Waitlist mortality, business, Demography, Lung allocation score
Abstract: The number of lung transplants performed continues to increase annually and reached an all-time high in 2019, with decreasing waitlist mortality. These trends are attributable to an increasing number of candidates listed for transplant each year and a continuing increase in the number of donors. Despite these favorable trends, 6.4% of lungs recovered for transplant were not transplanted in 2019, and strategies to optimize use of these available organs may reduce the number of waitlist even further. Time to transplant continued to decrease, as over 50% of candidates waited 3 months or less in 2019, yet regional heterogeneity remained despite policy changes intended to improve allocation equity. Small gains continued in posttransplant survival, with 1-year survival at 88.8%; 3 year, 74.4%; 5 year, 59.2%, and 10 year, 33.1 %.
Published: 2021

39. GPER1 is required to protect fetal health from maternal inflammation

Author: Nicholas S. Heaton, Jean K. Lim, Alfred T. Harding, Marisa Goff, and Heather M. Froggatt
Subjects: 0301 basic medicine, Placenta, Regulator, Estrogen receptor, Context (language use), Article, Receptors, G-Protein-Coupled, Mice, 03 medical and health sciences, Fetus, 0302 clinical medicine, Pregnancy, Interferon, Influenza, Human, medicine, Animals, Humans, Benzodioxoles, Pregnancy Complications, Infectious, Receptor, Maternal-Fetal Exchange, Inflammation, Multidisciplinary, business.industry, Fetal health, medicine.disease, Mice, Inbred C57BL, Fetal Diseases, 030104 developmental biology, Receptors, Estrogen, Influenza A virus, embryonic structures, Interferon Type I, Immunology, Quinolines, Female, CRISPR-Cas Systems, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: GPER1 in utero to the rescue! Several common pathogens, including influenza A virus (IAV), can activate systemic type I interferon (IFN) signaling during pregnancy. Such infections would be expected to cause birth defects and fetal mortality, but maternal IAV infections rarely produce such effects, suggesting the presence of a protective mechanism in fetal tissues. Harding et al. used a CRISPR screen to uncover IFN regulators that can mediate differential IFN control across tissues in human cell lines. They found that G protein–coupled estrogen receptor 1 (GPER1), which is expressed in fetal tissues, acts as a protective suppressor of IFN responses in the placenta during maternal infection. In a mouse model, pharmacological activation of GPER1 shielded fetuses from maternal inflammation. Activation of GPER1 might be promising therapeutically to protect the fetus from both maternal and fetal infections. Science , this issue p. 271
Published: 2021

40. Transitioning and re-membering of academics in times of upheaval

Author: Kristina Turner, Anat Wilson, Maryanne Pale, and Wendy Goff
Subjects: early career researcher, Economic growth, 2019-20 coronavirus outbreak, History, 030504 nursing, Higher education, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 05 social sciences, 050301 education, Outbreak, diffractive analysis, autobiographical writing, 03 medical and health sciences, Philosophy, performativity, Performativity, Pandemic, sense organs, transitioning, skin and connective tissue diseases, 0305 other medical science, business, 0503 education
Abstract: The higher education landscape has been amidst change over recent years. At the time of writing this paper, the pandemic outbreak has had a substantial impact on the higher education sector. This was our last year as early career researchers, but the prospect of promotion was replaced with managing unpredicted short-term job insecurity. In writing this article, we engage with collaborative diffractive autobiographical writing, re-membering, re-connecting and re-experiencing our autobiographical accounts, written at the beginning of our transition into academia. Through diffractive analysis, we shifted from positivistic approaches that assume a rigid separation between observer and the observed, to engage in an ongoing (re)pattering and (re)(con)figuring of our identities during this transition. In an intentional disruption of binary, we engage in writing as an event of interaction with texts, allowing ourselves to be affected by and experience these propositions in their mutual entanglements.
Published: 2021

41. First-ever treatment in multiple sclerosis

Author: G. Le Goff, Vasiliki Pantazou, Caroline Pot, R. Du Pasquier, and Marie Théaudin
Subjects: medicine.medical_specialty, Multiple Sclerosis, Dimethyl Fumarate, Population, Gastroenterology, law.invention, chemistry.chemical_compound, Randomized controlled trial, law, Internal medicine, medicine, Humans, In patient, Prospective Studies, education, Retrospective Studies, education.field_of_study, Dimethyl fumarate, business.industry, Multiple sclerosis, Incidence (epidemiology), medicine.disease, Fingolimod, Discontinuation, Treatment Outcome, Neurology, chemistry, Neurology (clinical), business, Immunosuppressive Agents, medicine.drug
Abstract: BACKGROUND The current treated MS population is very different from that of patients in randomized clinical trials. OBJECTIVES To study the long-term efficacy and tolerance of fingolimod (FTY) and dimethyl fumarate (DMF), both available as first-line treatment in early-treated treatment-naive MS patients. METHODS Retrospective analysis of 75 patients from our prospective MS registry fulfilling the inclusion criteria: FTY or DMF as first-line treatment, treatment initiation within 36months of disease onset and treatment duration>12months. RESULTS Demographics and MRI characteristics at baseline were similar in both groups (FTY 55 patients, DMF 20), but patients on FTY had higher pretreatment clinical activity (P=0.008). Twenty-two percent of patients in the FTY group and 15% in the DMF group had highly active disease. At last follow-up (mean: 44.2, SD: 17.3months), the majority of the patients were still on treatment while 54.5% of FTY and 65% of DMF patients reached NEDA 3 status (P=0.444). Both treatments significantly decreased relapses and occurrence of new T1 Gd-enhancing lesions (P
Published: 2021

42. MRI Features Associated With the Detection of Microbial Pathogens by CT-Guided Biopsy in Septic Spondylodiscitis

Author: Géraldine Bart, Christophe Rioux, Pascal Richette, Hervé Jacquier, Véronique Joly, Emilie Chotard, Elisabeth Palazzo, Yazdan Yazdanpanah, Benoit Le Goff, Marine Forien, Sébastien Ottaviani, Philippe Dieudé, Julia Goossens, and Germain Jelin
Subjects: Adult, Image-Guided Biopsy, Male, Spondylodiscitis, medicine.medical_specialty, Discitis, Rheumatology, Interquartile range, Edema, Biopsy, medicine, Humans, Intervertebral Disc, Abscess, Aged, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Intervertebral disc, Middle Aged, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Granuloma, Radiology, medicine.symptom, Tomography, X-Ray Computed, business
Abstract: OBJECTIVE The aim of this study was to assess the magnetic resonance imaging (MRI) features associated with microbial pathogen detection by computed tomography (CT)-guided biopsy in patients with suspected septic spondylodiscitis. METHODS For the last 10-year period, we analyzed the medical records of patients who underwent MRI and CT-guided biopsy for suspected septic spondylodiscitis. Clinical characteristics were recorded. The following MRI features were assessed: edema or contrast enhancement of the intervertebral disc, adjacent vertebrae, epidural and paravertebral space, presence of abscess, and paravertebral edema size. A positive biopsy was defined by pathogen identification on bacterial analysis or the presence of granuloma on histology. Predictors of a positive biopsy were assessed with a logistic regression model. RESULTS We analyzed data for 61 patients (34 [56%] male; mean age, 59.9 ± 18.0 years); for 35 patients (57%), CT-guided biopsy was positive for a pathogen. The 4 MRI findings significantly associated with a positive biopsy were epiduritis, greater than 50% vertebral endplate edema, loss of intradiscal cleft, and abscess. The size of paravertebral edema was greater with a positive than negative biopsy (median, 15.9 [interquartile range, 11.3-21.3] vs 7.3 [4.6-12.9] mm; p = 0.004). On multivariable analysis, epiduritis was the only independent predictor of a positive biopsy (adjusted odds ratio, 7.4 [95% confidence interval, 1.7-31.4]; p = 0.006). CONCLUSIONS Epiduritis and the size of paravertebral edema on MRI are associated with detection of a microbial pathogen in suspected septic spondylodiscitis. For patients without these MRI signs, the need for further investigations such as enriched or prolonged cultures, a second CT-guided biopsy, or even surgical biopsy need to be discussed.
Published: 2020

43. LDL apheresis as an alternate method for plasma LPS purification in healthy volunteers and dyslipidemic and septic patients

Author: Anne Laure Rerole, Alain Carrié, Samir Saheb, David Masson, Wilfried Le Goff, Isabelle Fournel, Randa Bittar, Hélène Choubley, Thomas Gautier, Jean-Pierre Quenot, Jean-Paul Pais de Barros, Auguste Dargent, Laurent Lagrost, Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer (LabEx LipSTIC), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Université de Montpellier (UM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Biochimie Métabolique [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Service de Biochimie Endocrinienne et Oncologie [CHU Pitié-Salpêtrière], Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de biochimie médicale (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Service de Réanimation Médicale (CHU de Dijon), Gestionnaire, Hal Sorbonne Université, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), and Laboratoire de biochimie médicale (CHU Dijon)
Subjects: Adult, Lipopolysaccharides, Male, 0301 basic medicine, Lipopolysaccharide, low density lipoprotein apheresis, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Inflammation, Familial hypercholesterolemia, QD415-436, 030204 cardiovascular system & hematology, Pharmacology, Biochemistry, Sepsis, sepsis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Humans, Medicine, Research Articles, polymyxin hemoperfusion, business.industry, Septic shock, lipopolysaccharide, Cell Biology, Hemoperfusion, medicine.disease, Healthy Volunteers, 3. Good health, [SDV] Life Sciences [q-bio], lipoproteins, 030104 developmental biology, chemistry, LDL apheresis, inflammation, Low-density lipoprotein, septic shock, Female, lipids (amino acids, peptides, and proteins), medicine.symptom, human and clinical research, business, low density lipoprotein, tandem mass spectroscopy
Abstract: International audience; Lipopolysaccharide (LPS) is a key player for innate immunity activation. It is therefore a prime target for sepsis treatment, as antibiotics are not sufficient to improve outcome during septic shock. An extracorporeal removal method by polymyxin (PMX) B direct hemoperfusion (PMX-DHP) is used in Japan, but recent trials failed to show a significant lowering of circulating LPS levels after PMX-DHP therapy. PMX-DHP has a direct effect on LPS molecules. However, LPS is not present in a free form in the circulation, as it is mainly carried by lipoproteins, including LDLs. Lipoproteins are critical for physiological LPS clearance, as LPSs are carried by LDLs to the liver for elimination. We hypothesized that LDL apheresis could be an alternate method for LPS removal. First, we demonstrated in vitro that LDL apheresis microbeads are almost as efficient as PMX beads to reduce LPS concentration in LPS-spiked human plasma, whereas it is not active in PBS. We found that PMX was also adsorbing lipoproteins, although less specifically. Then, we found that endogenous LPS of patients treated by LDL apheresis for familial hypercholesterolemia is also removed during their LDL apheresis sessions, with both electrostatic-based devices and filtration devices. Finally, LPS circulating in the plasma of septic shock and severe sepsis patients with gram-negative bacteremia was also removed in vitro by LDL adsorption. Overall, these results underline the importance of lipoproteins for LPS clearance, making them a prime target to study and treat endotoxemia-related conditions.
Published: 2020

44. Acromegaly is associated with vertebral deformations but not vertebral fractures: Results of a cross-sectional monocentric study

Author: Delphine Drui, Samy Hadjadj, Pascale Guillot, Clarisse Hochman, Benoit Le Goff, Charlotte Plard, Yves Maugars, and Bertrand Cariou
Subjects: Adult, Male, medicine.medical_specialty, Bone density, Radiography, Lumbar, Rheumatology, Bone Density, Acromegaly, Prevalence, Humans, Medicine, Aged, Bone mineral, Lumbar Vertebrae, business.industry, Middle Aged, medicine.disease, Cross-Sectional Studies, Radiological weapon, Cohort, Spinal Fractures, Female, Lumbar spine, Radiology, business
Abstract: Objectives Patients with acromegaly appear to be at increased risk of vertebral fractures despite normal bone mineral density. We investigated the prevalence of vertebral fractures in a cohort of acromegalic patients under 80 years of age. Methods Monocentric cross-sectional study performed at Nantes University Hospital from 1988 to 2018. Fifty patients (18 females, 32 males) with a median age of 52.3 years (range: 27–78) were included. Radiological vertebral fractures were evaluated on conventional lumbar and thoracic spine radiographs using Genant's semiquantitative fracture assessment. We studied qualitative abnormalities of the spine using three criteria: osteophytes, disc-space narrowing and wedge-shaped vertebrae. We analysed bone mineral density and endocrine status. Results Three patients (6%) had a vertebral fracture: one grade 1 and two grade 2 according to Genant's assessment, with two osteoporotic and one osteopenic patients. They had no unsubstituted pituitary deficiency. Considering the frank deformations (osteophyte or disc narrowing ≥ grade 2 or wedge-shaped), the thoracic spine was deformed in 22 patients (44%) and the lumbar spine in 21 patients (42%). Conclusion Acromegalic patients had a low prevalence of vertebral fractures but had a significant amount of vertebral deformations. We speculate that this high prevalence of frank deformations could explain the previously reported high prevalence of vertebral fractures.
Published: 2020

45. The Role of Antibiotic Stewardship and Telemedicine in the Management of Multidrug-Resistant Infections

Author: Thomas M. File, Robin L.P. Jump, and Debra A. Goff
Subjects: 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Telemedicine, medicine.drug_class, 030106 microbiology, Antibiotics, Antimicrobial Stewardship, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, Drug Resistance, Multiple, Bacterial, medicine, Humans, Antimicrobial stewardship, 030212 general & internal medicine, Intensive care medicine, business.industry, Bacterial Infections, On resistance, Anti-Bacterial Agents, Multiple drug resistance, Infectious Diseases, Antibiotic Stewardship, Public Health, Stewardship, business
Abstract: This article summarizes the literature describing how antimicrobial stewardship and telemedicine interventions affect antimicrobial resistance. Discussion includes why we need stewardship, how to collaborate with team members, and the evidence of stewardship's and telemedicine's impact on resistance.
Published: 2020

46. Incidence of Asymptomatic Brain Metastases in Metastatic Colorectal Cancer

Author: Stephanie L. Goff, Mackenzie L. Shindorf, and Mohammad S. Jafferji
Subjects: Adult, Male, Oncology, medicine.medical_specialty, Colorectal cancer, Autopsy, Disease, Asymptomatic, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Cumulative incidence, Aged, Neoplasm Staging, Retrospective Studies, Brain Neoplasms, business.industry, Incidence, Incidence (epidemiology), Gastroenterology, Brain, Cancer, Middle Aged, medicine.disease, 030220 oncology & carcinogenesis, Asymptomatic Diseases, Female, 030211 gastroenterology & hepatology, medicine.symptom, Colorectal Neoplasms, business, Brain metastasis
Abstract: Background Current literature suggests that brain metastasis is an infrequent occurrence in metastatic colorectal cancer. Outside of rare autopsy studies, these retrospective reports describe the incidence of symptomatic brain metastasis and therefore lack a description of the incidence in asymptomatic patients. With improved survival and a lack of routine brain imaging, the true incidence of brain metastasis among patients with metastatic colorectal cancer is likely under-recognized. At our research institution, protocol criteria require brain imaging regardless of neurologic symptoms. Therefore, we aim to describe the incidence of asymptomatic brain metastases in patients with metastatic colorectal cancer. Patients and Methods This study included patients with metastatic colorectal cancer enrolled onto a clinical trial screening protocol at the National Cancer Institute that underwent brain imaging (n = 171) between 2010 and 2019. Results The median age of patients at initial colorectal cancer diagnosis was 48.1 years. Most had stage IV disease with synchronous metastases. Twenty-five (14.6%) patients were identified with brain metastases, of which 19 (76%) were asymptomatic. Those with asymptomatic lesions were more likely to have presented with synchronous metastases, have a shorter time from primary diagnosis to development of metastatic disease, and have smaller brain metastases. Conclusion We identified a high number of asymptomatic brain metastasis and subsequently a higher cumulative incidence of brain metastases in patients with metastatic colorectal cancer than historical reports would suggest. This may represent a heretofore unknown aspect of the natural course of disease now being exposed owing to an increasing life expectancy of these patients and could play a pivotal role in therapeutic decisions.
Published: 2020

47. Burden of Chronic Kidney Disease by KDIGO Categories of Glomerular Filtration Rate and Albuminuria: A Systematic Review

Author: Elisabeth Sörstadius, Roberto Pecoits-Filho, Katherine R. Tuttle, Glen James, Stephen Nolan, Anna Bobrowska, Juan Jose Garcia Sanchez, Molly Murton, Eric Wittbrodt, and Danielle Goff-Leggett
Subjects: China, 030213 general clinical medicine, medicine.medical_specialty, Renal function, Review, urologic and male genital diseases, 03 medical and health sciences, Diabetes mellitus, 0302 clinical medicine, Risk Factors, Chronic kidney disease, Internal medicine, Epidemiology, Prevalence, CKD, medicine, Albuminuria, Humans, Pharmacology (medical), Renal Insufficiency, Chronic, Renal insufficiency, KDIGO, business.industry, Incidence (epidemiology), General Medicine, medicine.disease, female genital diseases and pregnancy complications, Rheumatology, Cardiovascular diseases, Italy, Spain, 030220 oncology & carcinogenesis, Hypertension, Observational study, France, medicine.symptom, business, Glomerular Filtration Rate, Kidney disease
Abstract: Introduction The Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines recommend classifying patients by glomerular filtration rate (GFR) and albuminuria to predict chronic kidney disease (CKD) prognosis. The aim of this systematic review was to explore the epidemiological burden of CKD stratified by the KDIGO 2012 categories. Methods MEDLINE® and Embase were searched for observational studies of patients with CKD with results stratified according to the KDIGO 2012 classification. Investigated outcomes were prevalence, incidence, and risk factors and complications of CKD, including mortality. Results The review included ten observational studies with 3033 to 46,949 participants, conducted in the USA, China, France, Italy and Spain. The most frequently reported outcome was the prevalence of CKD (GFR categories G3–5), ranging from 2% to 17%. Most participants were normoalbuminuric, with 0.4–3.2% macroalbuminuric, and most fell within the KDIGO 2012 low-risk or moderate-risk groups, with 0.9–5.6% in the high-risk and 0.3–4.8% in the very high-risk groups. Although scarce, data on the prevalence of comorbidities in CKD according to the KDIGO classification suggest that they increase with albuminuria severity. Conclusions Patients with CKD frequently have complications, but only a small proportion have severely increased albuminuria or fall within the KDIGO high-risk or very high-risk groups. These groups, however, are associated with the highest burden of disease, as comorbidities are more prevalent with increasing albuminuria severity. New studies framed by the KDIGO 2012 classification are needed to address key gaps in the understanding of CKD burden and outcomes. Electronic supplementary material The online version of this article (10.1007/s12325-020-01568-8) contains supplementary material, which is available to authorized users.
Published: 2020

48. 'Hybrid' medical leadership emergency medicine training for international medical graduates

Author: Pamela Goff, Prakash Subedi, Dayaram Lamsal, Jill Aylott, Naushad Khan, and Niki Shrestha
Subjects: medicine.medical_specialty, Quality management, Leadership development, business.industry, 030503 health policy & services, 03 medical and health sciences, 0302 clinical medicine, Tier 2 network, General partnership, Political science, Return on investment, Emergency medicine, Health care, Added value, medicine, 030212 general & internal medicine, 0305 other medical science, business, Curriculum
Abstract: Purpose The purpose of this paper is to outline the “Hybrid” “International” Emergency Medicine (HIEM) programme, which is an ethical pathway for the recruitment, employment and training of Emergency Medicine doctors; with a rotation through the NHS on a two-year medical training initiative with a Tier 5 visa, “earn, learn and return” programme. The HIEM programme offers an advantage to the Tier 2 visa by combining training, education and employment resulting in new learning to help improve the health system in Nepal and provide continued cultural support, clinical and leadership development experience in the UK NHS. Finally, this programme also provides a Return on Investment to the NHS. Design/methodology/approach A shortage of doctors in the UK, combined with a need to develop Emergency Medicine doctors in Nepal, led to a UK Emergency Medicine Physician (PS) to facilitate collaboration between UK/Nepal partners. A mapping exercise of the Royal College of Emergency Medicine curriculum with the competencies for the health system and quality improvement leaders and partners with patients produced a “HIEM programme”. The HIEM programme aims to develop first-class doctors to study in Emergency Departments in the UK NHS while also building trainee capability to improve the health system in Nepal with a research thesis. Findings The HIEM programme has 12 doctors on its programme across years one and two, with the first six doctors working in the UK NHS and progressing well. There are reports of high levels of satisfaction with the trainees in their transition from Nepal to the UK and the hospital is due to save £720,000 (after costs) over two years. Each trainee will earn £79,200 over two years which is enough to pay back the £16,000 cost for the course fees. Nepal as a country will benefit from the HIEM programme as each trainee will submit a health system improvement Thesis. Research limitations/implications The HIEM programme is in its infancy as it is two years through a four-year programme. Further evaluation data are required to assess the full impact of this programme. In addition, the HIEM programme has only focussed on the development of one medical speciality which is Emergency Medicine. Further research is required to evaluate the impact of this model across other medical and surgical specialties. Practical implications The HIEM programme has exciting potential to support International Medical Graduates undertake a planned programme of development while they study in the UK with a Tier 5 visa. IMGs require continuous support while in the UK and are required to demonstrate continued learning through continuous professional development (CPD). The HIEM programme offers an opportunity for this CPD learning to be structured, meaningful and progressive to enable new learning. There is also specific support to develop academic and research skills to undertake a thesis in an area that requires health system improvement in Nepal. Originality/value This is the first time an integrated clinical, leadership, quality improvement and patient partnership model curriculum has been developed. The integrated nature of the curriculum saves precious time, money and resources. The integrated nature of this “hybrid” curriculum supports the development of an evidence-based approach to generating attitudes of collaboration, partnership and facilitation and team building in medical leadership with patient engagement. This “hybrid” model gives hope for the increased added value of the programme at a time of global austerity and challenges in healthcare.
Published: 2020

49. Long-Term Follow-Up of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy

Author: Kathryn M Cappell, Danielle Vanasse, Stephanie L. Goff, Lori McIntyre, James Chih-Hsin Yang, Steven A. Rosenberg, James N. Kochenderfer, and Richard M. Sherry
Subjects: Adult, Male, 0301 basic medicine, Cancer Research, Lymphoma, B-Cell, medicine.medical_treatment, Antigens, CD19, Immunoglobulins, Immunotherapy, Adoptive, 03 medical and health sciences, 0302 clinical medicine, Antigen, hemic and lymphatic diseases, medicine, Humans, Adverse effect, Receptor, Aged, B-Lymphocytes, Receptors, Chimeric Antigen, business.industry, ORIGINAL REPORTS, Immunotherapy, Middle Aged, medicine.disease, Fusion protein, Chimeric antigen receptor, Lymphoma, Survival Rate, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, Female, Chimeric Antigen Receptor T-Cell Therapy, business, Follow-Up Studies
Abstract: PURPOSE Anti-CD19 chimeric antigen receptors (CARs) are artificial fusion proteins that cause CD19-specific T-cell activation. Durability of remissions and incidence of long-term adverse events are critical factors determining the utility of anti-CD19 CAR T-cell therapy, but long-term follow-up of patients treated with anti-CD19 CAR T cells is limited. This work provides the longest follow-up of patients in remission after anti-CD19 CAR T-cell therapy. METHODS Between 2009 and 2015, we administered 46 CAR T-cell treatments to 43 patients (ClinicalTrials.gov identifier: NCT00924326 ). Patients had relapsed B-cell malignancies of the following types: diffuse large B-cell lymphoma or primary mediastinal B-cell lymphoma (DLBCL/PMBCL; n = 28), low-grade B-cell lymphoma (n = 8), or chronic lymphocytic leukemia (CLL; n = 7). This report focuses on long-term outcomes of these patients. The CAR used was FMC63-28Z; axicabtagene ciloleucel uses the same CAR. Cyclophosphamide plus fludarabine conditioning chemotherapy was administered before CAR T cells. RESULTS The percentages of CAR T-cell treatments resulting in a > 3-year duration of response (DOR) were 51% (95% CI, 35% to 67%) for all evaluable treatments, 48% (95% CI, 28% to 69%) for DLBCL/PMBCL, 63% (95% CI, 25% to 92%) for low-grade lymphoma, and 50% (95% CI, 16% to 84%) for CLL. The median event-free survival of all 45 evaluable treatments was 55 months. Long-term adverse effects were rare, except for B-cell depletion and hypogammaglobulinemia. Median peak blood CAR-positive cell levels were higher among patients with a DOR of > 3 years (98/µL; range, 9-1,217/µL) than among patients with a DOR of < 3 years (18/µL; range, 0-308/μL, P = .0051). CONCLUSION Complete remissions of a variety of B-cell malignancies lasting ≥ 3 years occurred after 51% of evaluable anti-CD19 CAR T-cell treatments. Remissions of up to 9 years are ongoing. Late adverse events were rare.
Published: 2020

50. Postoperative, Single-Fraction Radiation Therapy in Merkel Cell Carcinoma of the Head and Neck

Author: Stephanie K. Schaub, Alex Fu, Peter H. Goff, Smith Apisarnthanarax, Shailender Bhatia, Maclean M. Cook, Song Youn Park, Upendra Parvathaneni, Jay J. Liao, Paul Nghiem, Daniel S. Hippe, and Yolanda D. Tseng
Subjects: medicine.medical_specialty, Merkel cell carcinoma, business.industry, medicine.medical_treatment, Common Terminology Criteria for Adverse Events, Immunosuppression, medicine.disease, Article, Single fraction, Acute toxicity, 030218 nuclear medicine & medical imaging, Radiation therapy, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Toxicity, medicine, Radiology, Nuclear Medicine and imaging, Radiology, Head and neck, business
Abstract: Purpose Conventionally fractionated, post-operative radiotherapy (cPORT; 50 Gy in 25 fractions) is considered for patients with Merkel cell carcinoma (MCC) to improve locoregional control. However, cPORT is associated with acute toxicity, especially in the head and neck (H&N) region, and requires daily treatments over several weeks. We previously reported high rates of durable local control with minimal toxicity using 8 Gy single-fraction radiation therapy (SFRT) in the metastatic setting. We report early results on a cohort of patients with localized H&N MCC, who received post operative SFRT if a cPORT regimen was not feasible. Methods Twelve patients with localized MCC of the H&N (clinical/pathologic stages: I-II) and no prior RT to the region were identified from an IRB-approved prospective registry who underwent surgical resection followed by post operative SFRT. Time-to-event was calculated starting from the date of resection prior to SFRT. The cumulative incidence of in-field locoregional recurrences and out-of-field recurrences was estimated with death as a competing risk. Results Twelve H&N MCC patients were identified with clinical/pathologic stages I-II H&N MCC. Median age at diagnosis was 81 years (58-96); 25% had immunosuppression. At a median follow-up of 19 months (range: 8-34), there were no in-field locoregional recurrences. A single out-of-field regional recurrence was observed, which was successfully salvaged. There were no MCC specific-deaths. No radiation-associated toxicities greater than grade 1 (CTCAE v5) were observed. Conclusions Preliminary data suggest that SFRT could offer a potential alternative to cPORT to treat the primary site for localized H&N MCC, particularly in elderly or frail patients, with promising in-field local control and minimal toxicity. Further data with validation in larger cohorts is needed to confirm the sustained safety and efficacy of post operative SFRT., Merkel cell carcinoma (MCC) is often treated with excision followed by conventional fractionated radiotherapy for localized disease. Single fraction radiation therapy (SFRT) has been shown to be effective for treating patients with metastatic MCC. This study presents early results for patients with MCC of the head and neck treated with 8 Gy SFRT to the post operative bed following surgery.
Published: 2020

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